| US1434314A              (en) | 1921-08-04 | 1922-10-31 | Raich Anthony | Lunch pail | 
| US1616419A              (en) | 1925-04-03 | 1927-02-01 | Everlasting Valve Co | Automatic shut-off device for gas in case of fire | 
| US1733401A              (en) | 1928-03-29 | 1929-10-29 | Christman Matthias | Journal box | 
| US3528449A              (en) | 1968-02-27 | 1970-09-15 | Trw Inc | Fluid flow control apparatus | 
| US4038192A              (en) | 1973-12-03 | 1977-07-26 | International Biomedical Laboratories, Inc. | Device for exchange between fluids suitable for treatment of blood | 
| US3985649A              (en) | 1974-11-25 | 1976-10-12 | Eddelman Roy T | Ferromagnetic separation process and material | 
| JPS5255578A              (en) | 1975-10-31 | 1977-05-07 | Hitachi Ltd | Analyzing apparatus | 
| US4018652A              (en) | 1976-01-09 | 1977-04-19 | Mcdonnell Douglas Corporation | Process and apparatus for ascertaining the concentration of microorganism in a water specimen | 
| US4018089A              (en) | 1976-05-05 | 1977-04-19 | Beckman Instruments, Inc. | Fluid sampling apparatus | 
| USD252157S              (en) | 1977-04-14 | 1979-06-19 | Warner-Lambert Company | Diagnostic device for measuring biochemical characteristics of microorganisms and the like | 
| USD252341S              (en) | 1977-05-12 | 1979-07-10 | Ryder International Corporation | Testing tray | 
| JPS5416896A              (en) | 1977-06-21 | 1979-02-07 | Asahi Medical Co | Blood dialyser | 
| US4139005A              (en) | 1977-09-01 | 1979-02-13 | Dickey Gilbert C | Safety release pipe cap | 
| USD254687S              (en) | 1979-01-25 | 1980-04-08 | Mcdonnell Douglas Corporation | Biochemical card for use with an automated microbial identification machine | 
| USD261033S              (en) | 1979-02-05 | 1981-09-29 | American Optical Corporation | Bilirubin concentration analyzer | 
| USD261173S              (en) | 1979-02-05 | 1981-10-06 | American Optical Corporation | Bilirubinometer | 
| US4301412A              (en) | 1979-10-29 | 1981-11-17 | United States Surgical Corporation | Liquid conductivity measuring system and sample cards therefor | 
| JPS5766361A              (en) | 1980-10-09 | 1982-04-22 | Olympus Optical Co Ltd | Plate-shaped apparatus for judging cohesion of particle | 
| US4457329A              (en) | 1981-12-04 | 1984-07-03 | Air Products And Chemicals, Inc. | Safety pressure regulator | 
| JPS58212921A              (en) | 1982-06-04 | 1983-12-10 | Aron Kasei Co Ltd | Molding method for plastic hollow moldings | 
| USD279817S              (en) | 1982-07-19 | 1985-07-23 | Daryl Laboratories, Inc. | Immunoassay test slide | 
| US4504582A              (en) | 1982-07-20 | 1985-03-12 | Genex Corporation | Vermiculite as a carrier support for immobilized biological materials | 
| US4439526A              (en) | 1982-07-26 | 1984-03-27 | Eastman Kodak Company | Clustered ingress apertures for capillary transport devices and method of use | 
| DE3376763D1              (en) | 1982-09-02 | 1988-06-30 | Hettich Andreas Fa | Centrifugation chambers for the cytodiagnostic preparation of epithelial cells and their application | 
| US4522786A              (en) | 1983-08-10 | 1985-06-11 | E. I. Du Pont De Nemours And Company | Multilayered test device for detecting analytes in liquid test samples | 
| US4673657A              (en) | 1983-08-26 | 1987-06-16 | The Regents Of The University Of California | Multiple assay card and system | 
| US4599315A              (en) | 1983-09-13 | 1986-07-08 | University Of California Regents | Microdroplet test apparatus | 
| USD292735S              (en) | 1983-11-02 | 1987-11-10 | A/S Nunc | Tube for the immunological adsorption analysis | 
| US4654127A              (en) | 1984-04-11 | 1987-03-31 | Sentech Medical Corporation | Self-calibrating single-use sensing device for clinical chemistry and method of use | 
| JP2502961B2              (en) | 1984-04-26 | 1996-05-29 | 日本碍子株式会社 | Method for manufacturing electrochemical device | 
| USD288478S              (en) | 1984-06-21 | 1987-02-24 | Sentech Medical Corporation | Clinical chemistry analyzer | 
| DE3688029T2              (en) | 1985-03-13 | 1993-06-24 | Baxter Int | BLOOD PLATE COLLECTION SYSTEM. | 
| US4683195A              (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences | 
| US4683202A              (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences | 
| US4612959A              (en) | 1985-05-07 | 1986-09-23 | Mobil Oil Corporation | Valveless shut-off and transfer device | 
| US4963498A              (en) | 1985-08-05 | 1990-10-16 | Biotrack | Capillary flow device | 
| DE3614955C1              (en) | 1986-05-02 | 1987-08-06 | Schulz Peter | Sample distribution system | 
| US4978622A              (en) | 1986-06-23 | 1990-12-18 | Regents Of The University Of California | Cytophaga-derived immunopotentiator | 
| US5763262A              (en) | 1986-09-18 | 1998-06-09 | Quidel Corporation | Immunodiagnostic device | 
| USD302294S              (en) | 1986-10-03 | 1989-07-18 | Biotrack, Inc. | Reagent cartridge for blood analysis | 
| US4935342A              (en) | 1986-12-01 | 1990-06-19 | Syngene, Inc. | Method of isolating and purifying nucleic acids from biological samples | 
| US4978502A              (en) | 1987-01-05 | 1990-12-18 | Dole Associates, Inc. | Immunoassay or diagnostic device and method of manufacture | 
| US5004583A              (en) | 1987-01-29 | 1991-04-02 | Medtest Systems, Inc. | Universal sensor cartridge for use with a universal analyzer for sensing components in a multicomponent fluid | 
| US4946562A              (en) | 1987-01-29 | 1990-08-07 | Medtest Systems, Inc. | Apparatus and methods for sensing fluid components | 
| US5599667A              (en) | 1987-03-02 | 1997-02-04 | Gen-Probe Incorporated | Polycationic supports and nucleic acid purification separation and hybridization | 
| US5001417A              (en) | 1987-06-01 | 1991-03-19 | Abbott Laboratories | Apparatus for measuring electrolytes utilizing optical signals related to the concentration of the electrolytes | 
| US5192507A              (en) | 1987-06-05 | 1993-03-09 | Arthur D. Little, Inc. | Receptor-based biosensors | 
| JPH01503808A              (en) | 1987-07-16 | 1989-12-21 | イー・アイ・デユポン・ド・ネモアース・アンド・コンパニー(インコーポレイテツド) | Affinity separation using immobilized flocculants | 
| GB8720470D0              (en) | 1987-08-29 | 1987-10-07 | Emi Plc Thorn | Sensor arrangements | 
| US4921809A              (en) | 1987-09-29 | 1990-05-01 | Findley Adhesives, Inc. | Polymer coated solid matrices and use in immunoassays | 
| USD310413S              (en) | 1987-12-17 | 1990-09-04 | Miles Inc. | Sample processor | 
| US4895650A              (en) | 1988-02-25 | 1990-01-23 | Gen-Probe Incorporated | Magnetic separation rack for diagnostic assays | 
| US5503803A              (en) | 1988-03-28 | 1996-04-02 | Conception Technologies, Inc. | Miniaturized biological assembly | 
| DE3811713A1              (en) | 1988-04-08 | 1989-10-19 | Bosch Gmbh Robert | PLANAR POLAROGRAPHIC PROBE FOR DETERMINING THE (LAMBDA) VALUE OF GAS MIXTURES | 
| US5700637A              (en) | 1988-05-03 | 1997-12-23 | Isis Innovation Limited | Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays | 
| US5060823A              (en) | 1988-09-15 | 1991-10-29 | Brandeis University | Sterile transfer system | 
| US5096669A              (en) | 1988-09-15 | 1992-03-17 | I-Stat Corporation | Disposable sensing device for real time fluid analysis | 
| JPH0814337B2              (en) | 1988-11-11 | 1996-02-14 | 株式会社日立製作所 | Opening / closing control valve and opening / closing control method for flow path using phase change of fluid itself | 
| US5530101A              (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins | 
| US4919829A              (en) | 1988-12-30 | 1990-04-24 | The United States Of America As Represented By The Secretary Of Commerce | Aluminum hydroxides as solid lubricants | 
| US5053199A              (en) | 1989-02-21 | 1991-10-01 | Boehringer Mannheim Corporation | Electronically readable information carrier | 
| US5416000A              (en) | 1989-03-16 | 1995-05-16 | Chemtrak, Inc. | Analyte immunoassay in self-contained apparatus | 
| FI86229C              (en) | 1989-04-10 | 1992-07-27 | Niilo Kaartinen | FOERFARANDE FOER FORMNING AV ETT UPPVAERMBART OCH NEDKYLBART ELEMENT VID ETT SYSTEM BEHANDLANDE SMAO VAETSKEMAENGDER SAMT ETT MEDELST FOERFARANDET FRAMSTAELLT ELEMENT. | 
| US4949742A              (en) | 1989-04-26 | 1990-08-21 | Spectra-Physics, Inc. | Temperature operated gas valve | 
| US5135872A              (en) | 1989-04-28 | 1992-08-04 | Sangstat Medical Corporation | Matrix controlled method of delayed fluid delivery for assays | 
| US5061336A              (en) | 1989-05-01 | 1991-10-29 | Soane Technologies, Inc. | Gel casting method and apparatus | 
| US5071531A              (en) | 1989-05-01 | 1991-12-10 | Soane Technologies, Inc. | Casting of gradient gels | 
| AU109440S              (en) | 1989-05-03 | 1990-10-31 | Bayer Diagnostic G M B H | Diagnostic working station evaluation device | 
| USD328794S              (en) | 1989-07-19 | 1992-08-18 | Pb Diagnostic Systems, Inc. | Diagnostic instrument or similar article | 
| AU635314B2              (en) | 1989-09-08 | 1993-03-18 | Terumo Kabushiki Kaisha | Measuring apparatus | 
| EP0420560B1              (en) | 1989-09-29 | 1993-11-18 | Glory Kogyo Kabushiki Kaisha | Leaf paper bundling apparatus | 
| US5275787A              (en) | 1989-10-04 | 1994-01-04 | Canon Kabushiki Kaisha | Apparatus for separating or measuring particles to be examined in a sample fluid | 
| LU87601A1              (en) | 1989-10-05 | 1990-02-07 | Ceodeux Sa | TAP FOR GAS BOTTLE | 
| USD324426S              (en) | 1989-10-20 | 1992-03-03 | Pacific Biotech, Inc. | Reaction unit for use in analyzing biological fluids | 
| US4967950A              (en) | 1989-10-31 | 1990-11-06 | International Business Machines Corporation | Soldering method | 
| US5252743A              (en) | 1989-11-13 | 1993-10-12 | Affymax Technologies N.V. | Spatially-addressable immobilization of anti-ligands on surfaces | 
| US5091328A              (en) | 1989-11-21 | 1992-02-25 | National Semiconductor Corporation | Method of late programming MOS devices | 
| US5279936A              (en) | 1989-12-22 | 1994-01-18 | Syntex (U.S.A.) Inc. | Method of separation employing magnetic particles and second medium | 
| USD328135S              (en) | 1990-01-12 | 1992-07-21 | Pacific Biotech, Inc. | Reaction unit for use in analyzing biological fluids | 
| US5858188A              (en) | 1990-02-28 | 1999-01-12 | Aclara Biosciences, Inc. | Acrylic microchannels and their use in electrophoretic applications | 
| US6054034A              (en) | 1990-02-28 | 2000-04-25 | Aclara Biosciences, Inc. | Acrylic microchannels and their use in electrophoretic applications | 
| US5770029A              (en) | 1996-07-30 | 1998-06-23 | Soane Biosciences | Integrated electrophoretic microdevices | 
| US5126022A              (en) | 1990-02-28 | 1992-06-30 | Soane Tecnologies, Inc. | Method and device for moving molecules by the application of a plurality of electrical fields | 
| US5935401A              (en) | 1996-09-18 | 1999-08-10 | Aclara Biosciences | Surface modified electrophoretic chambers | 
| US5750015A              (en) | 1990-02-28 | 1998-05-12 | Soane Biosciences | Method and device for moving molecules by the application of a plurality of electrical fields | 
| GB9007791D0              (en) | 1990-04-06 | 1990-06-06 | Foss Richard C | High voltage boosted wordline supply charge pump and regulator for dram | 
| AU639575B2              (en) | 1990-05-01 | 1993-07-29 | Enprotech Corporation | Integral biomolecule preparation device | 
| US5667976A              (en) | 1990-05-11 | 1997-09-16 | Becton Dickinson And Company | Solid supports for nucleic acid hybridization assays | 
| US5147606A              (en) | 1990-08-06 | 1992-09-15 | Miles Inc. | Self-metering fluid analysis device | 
| US5208163A              (en) | 1990-08-06 | 1993-05-04 | Miles Inc. | Self-metering fluid analysis device | 
| US5135627A              (en) | 1990-10-15 | 1992-08-04 | Soane Technologies, Inc. | Mosaic microcolumns, slabs, and separation media for electrophoresis and chromatography | 
| EP0484278B1              (en) | 1990-11-01 | 1995-04-12 | Ciba-Geigy Ag | Device for preparing liquid samples for chemical analysis | 
| DE59104604D1              (en) | 1990-11-26 | 1995-03-23 | Ciba Geigy Ag | Detector cell. | 
| FR2672301A1              (en) | 1991-02-01 | 1992-08-07 | Larzul Daniel | Process and device for amplifying the number of a defined sequence of nucleic acid in a biological sample | 
| US5327038A              (en) | 1991-05-09 | 1994-07-05 | Rockwell International Corporation | Walking expansion actuator | 
| JPH05345900A              (en) | 1991-07-08 | 1993-12-27 | Fuji Oil Co Ltd | Hard fat production method | 
| DE4123348A1              (en) | 1991-07-15 | 1993-01-21 | Boehringer Mannheim Gmbh | ELECTROCHEMICAL ANALYSIS SYSTEM | 
| IT1249433B              (en) | 1991-08-06 | 1995-02-23 | Pompeo Moscetta | PROCEDURE FOR DOSING ANALYTES IN LIQUID SAMPLES AND RELATED EQUIPMENT. | 
| US5474796A              (en) | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface | 
| US5256376A              (en) | 1991-09-12 | 1993-10-26 | Medical Laboratory Automation, Inc. | Agglutination detection apparatus | 
| EP0606309B1              (en) | 1991-10-04 | 1995-08-30 | Alcan International Limited | Peelable laminated structures and process for production thereof | 
| CA2074671A1              (en) | 1991-11-04 | 1993-05-05 | Thomas Bormann | Device and method for separating plasma from a biological fluid | 
| USD347478S              (en) | 1991-11-05 | 1994-05-31 | Hybaid Ltd. | Laboratory instrument for handling bimolecular samples | 
| US5605662A              (en) | 1993-11-01 | 1997-02-25 | Nanogen, Inc. | Active programmable electronic devices for molecular biological analysis and diagnostics | 
| US5787032A              (en) | 1991-11-07 | 1998-07-28 | Nanogen | Deoxyribonucleic acid(DNA) optical storage using non-radiative energy transfer between a donor group, an acceptor group and a quencher group | 
| US5632957A              (en) | 1993-11-01 | 1997-05-27 | Nanogen | Molecular biological diagnostic systems including electrodes | 
| ATE272068T1              (en) | 1991-11-07 | 2004-08-15 | Nanotronics Inc | HYBRIDIZATION OF POLYNUCLEOTIDES CONJUGATED WITH CHROMOPHORES AND FLUOROPHORES TO GENERATE A DONOR-DONOR ENERGY TRANSFER SYSTEM | 
| US5849486A              (en) | 1993-11-01 | 1998-12-15 | Nanogen, Inc. | Methods for hybridization analysis utilizing electrically controlled hybridization | 
| USD351475S              (en) | 1992-01-30 | 1994-10-11 | Jan Gerber | Skin patch for testing allergic reactions | 
| US5559432A              (en) | 1992-02-27 | 1996-09-24 | Logue; Delmar L. | Joystick generating a polar coordinates signal utilizing a rotating magnetic field within a hollow toroid core | 
| DE69331067T2              (en) | 1992-04-06 | 2002-07-11 | Abbott Laboratories, Abbott Park | METHOD AND DEVICE FOR DETECTING NUCLEIC ACID OR ANALYZES USING INTERNAL TOTAL REFLECTION | 
| US5223226A              (en) | 1992-04-14 | 1993-06-29 | Millipore Corporation | Insulated needle for forming an electrospray | 
| US6235313B1              (en) | 1992-04-24 | 2001-05-22 | Brown University Research Foundation | Bioadhesive microspheres and their use as drug delivery and imaging systems | 
| US5498392A              (en) | 1992-05-01 | 1996-03-12 | Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification device and method | 
| US5726026A              (en) | 1992-05-01 | 1998-03-10 | Trustees Of The University Of Pennsylvania | Mesoscale sample preparation device and systems for determination and processing of analytes | 
| US5637469A              (en) | 1992-05-01 | 1997-06-10 | Trustees Of The University Of Pennsylvania | Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems | 
| US5587128A              (en) | 1992-05-01 | 1996-12-24 | The Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification devices | 
| US5744366A              (en) | 1992-05-01 | 1998-04-28 | Trustees Of The University Of Pennsylvania | Mesoscale devices and methods for analysis of motile cells | 
| US5486335A              (en) | 1992-05-01 | 1996-01-23 | Trustees Of The University Of Pennsylvania | Analysis based on flow restriction | 
| US5304487A              (en) | 1992-05-01 | 1994-04-19 | Trustees Of The University Of Pennsylvania | Fluid handling in mesoscale analytical devices | 
| US5296375A              (en) | 1992-05-01 | 1994-03-22 | Trustees Of The University Of Pennsylvania | Mesoscale sperm handling devices | 
| US6953676B1              (en) | 1992-05-01 | 2005-10-11 | Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification device and method | 
| US5401465A              (en) | 1992-05-05 | 1995-03-28 | Chiron Corporation | Luminometer with reduced sample crosstalk | 
| US5364591A              (en) | 1992-06-01 | 1994-11-15 | Eastman Kodak Company | Device for moving a target-bearing solid through a liquid for detection while being contained | 
| US5414245A              (en) | 1992-08-03 | 1995-05-09 | Hewlett-Packard Corporation | Thermal-ink heater array using rectifying material | 
| US5639423A              (en) | 1992-08-31 | 1997-06-17 | The Regents Of The University Of Calfornia | Microfabricated reactor | 
| DE4231966A1              (en) | 1992-09-24 | 1994-03-31 | Bosch Gmbh Robert | Planar polarographic probe for determining the lambda value of gas mixtures | 
| US5422271A              (en) | 1992-11-20 | 1995-06-06 | Eastman Kodak Company | Nucleic acid material amplification and detection without washing | 
| US5569364A              (en) | 1992-11-05 | 1996-10-29 | Soane Biosciences, Inc. | Separation media for electrophoresis | 
| US5885432A              (en) | 1992-11-05 | 1999-03-23 | Soane Biosciences | Un-crosslinked polymeric media for electrophoresis | 
| US5500187A              (en) | 1992-12-08 | 1996-03-19 | Westinghouse Electric Corporation | Disposable optical agglutination assay device and method for use | 
| US5302348A              (en) | 1992-12-10 | 1994-04-12 | Itc Corporation | Blood coagulation time test apparatus and method | 
| US5311996A              (en) | 1993-01-05 | 1994-05-17 | Duffy Thomas J | Edge protector | 
| DE4334834A1              (en) | 1993-10-13 | 1995-04-20 | Andrzej Dr Ing Grzegorzewski | Biosensor for measuring changes in viscosity and / or density | 
| FI932866A0              (en) | 1993-06-21 | 1993-06-21 | Labsystems Oy | Separeringsfoerfarande | 
| USD351913S              (en) | 1993-02-25 | 1994-10-25 | Diametrics Medical, Inc. | Disposable electrochemical measurement cartridge for a portable medical analyzer | 
| US5339486A              (en) | 1993-03-10 | 1994-08-23 | Persic Jr William V | Golf ball cleaner | 
| US5565171A              (en) | 1993-05-28 | 1996-10-15 | Governors Of The University Of Alberta | Continuous biochemical reactor for analysis of sub-picomole quantities of complex organic molecules | 
| US5397709A              (en) | 1993-08-27 | 1995-03-14 | Becton Dickinson And Company | System for detecting bacterial growth in a plurality of culture vials | 
| JP2948069B2              (en) | 1993-09-20 | 1999-09-13 | 株式会社日立製作所 | Chemical analyzer | 
| US5374395A              (en) | 1993-10-14 | 1994-12-20 | Amoco Corporation | Diagnostics instrument | 
| DE59410283D1              (en) | 1993-11-11 | 2003-06-18 | Aclara Biosciences Inc | Device and method for the electrophoretic separation of fluid substance mixtures | 
| DE4343089A1              (en) | 1993-12-17 | 1995-06-29 | Bosch Gmbh Robert | Planar sensor element based on solid electrolyte | 
| DE4408361C2              (en) | 1994-03-14 | 1996-02-01 | Bosch Gmbh Robert | Electrochemical sensor for determining the oxygen concentration in gas mixtures | 
| WO1995025815A1              (en) | 1994-03-24 | 1995-09-28 | Gamera Bioscience Corporation | A dna meltometer and methods of use thereof | 
| US5580523A              (en) | 1994-04-01 | 1996-12-03 | Bard; Allen J. | Integrated chemical synthesizers | 
| USD366116S              (en) | 1994-05-03 | 1996-01-09 | Thomas Biskupski | Electrical box for storing dental wax | 
| US6001229A              (en) | 1994-08-01 | 1999-12-14 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing microfluidic manipulations for chemical analysis | 
| CA2156226C              (en) | 1994-08-25 | 1999-02-23 | Takayuki Taguchi | Biological fluid analyzing device and method | 
| US5627041A              (en) | 1994-09-02 | 1997-05-06 | Biometric Imaging, Inc. | Disposable cartridge for an assay of a biological sample | 
| US5585069A              (en) | 1994-11-10 | 1996-12-17 | David Sarnoff Research Center, Inc. | Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis | 
| US5632876A              (en) | 1995-06-06 | 1997-05-27 | David Sarnoff Research Center, Inc. | Apparatus and methods for controlling fluid flow in microchannels | 
| KR100314996B1              (en) | 1994-11-10 | 2002-01-15 | 윌리암 제이. 버크 | Liquid distribution system | 
| US5603351A              (en) | 1995-06-07 | 1997-02-18 | David Sarnoff Research Center, Inc. | Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device | 
| US5731212A              (en) | 1994-12-20 | 1998-03-24 | International Technidyne Corporation | Test apparatus and method for testing cuvette accommodated samples | 
| US6884357B2              (en) | 1995-02-21 | 2005-04-26 | Iqbal Waheed Siddiqi | Apparatus and method for processing magnetic particles | 
| US5579928A              (en) | 1995-03-06 | 1996-12-03 | Anukwuem; Chidi I. | Test tube holder with lock down clamp | 
| US6967088B1              (en) | 1995-03-16 | 2005-11-22 | Allergan, Inc. | Soluble recombinant botulinum toxin proteins | 
| US5674394A              (en) | 1995-03-24 | 1997-10-07 | Johnson & Johnson Medical, Inc. | Single use system for preparation of autologous plasma | 
| US5578818A              (en) | 1995-05-10 | 1996-11-26 | Molecular Dynamics | LED point scanning system | 
| WO1996039260A1              (en) | 1995-06-06 | 1996-12-12 | David Sarnoff Research Center, Inc. | Method of producing micro-electrical conduits | 
| EP0836487A1              (en) | 1995-06-06 | 1998-04-22 | Quantic Biomedical Partners | Device and method for concentrating plasma | 
| US6228635B1              (en) | 1995-06-07 | 2001-05-08 | Aastrom Bioscience, Inc. | Portable cell growth cassette for use in maintaining and growing biological cells | 
| US5589136A              (en) | 1995-06-20 | 1996-12-31 | Regents Of The University Of California | Silicon-based sleeve devices for chemical reactions | 
| US5856174A              (en) | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device | 
| US6168948B1              (en) | 1995-06-29 | 2001-01-02 | Affymetrix, Inc. | Miniaturized genetic analysis systems and methods | 
| US20020022261A1              (en) | 1995-06-29 | 2002-02-21 | Anderson Rolfe C. | Miniaturized genetic analysis systems and methods | 
| US6158269A              (en) | 1995-07-13 | 2000-12-12 | Bayer Corporation | Method and apparatus for aspirating and dispensing sample fluids | 
| US5872010A              (en) | 1995-07-21 | 1999-02-16 | Northeastern University | Microscale fluid handling system | 
| US5849208A              (en) | 1995-09-07 | 1998-12-15 | Microfab Technoologies, Inc. | Making apparatus for conducting biochemical analyses | 
| US6130098A              (en) | 1995-09-15 | 2000-10-10 | The Regents Of The University Of Michigan | Moving microdroplets | 
| US6911183B1              (en) | 1995-09-15 | 2005-06-28 | The Regents Of The University Of Michigan | Moving microdroplets | 
| US6057149A              (en) | 1995-09-15 | 2000-05-02 | The University Of Michigan | Microscale devices and reactions in microscale devices | 
| US6048734A              (en) | 1995-09-15 | 2000-04-11 | The Regents Of The University Of Michigan | Thermal microvalves in a fluid flow method | 
| GB9519346D0              (en) | 1995-09-22 | 1995-11-22 | English Glass Company The Limi | Dispensing systems | 
| US5628890A              (en) | 1995-09-27 | 1997-05-13 | Medisense, Inc. | Electrochemical sensor | 
| US20020068357A1              (en) | 1995-09-28 | 2002-06-06 | Mathies Richard A. | Miniaturized integrated nucleic acid processing and analysis device and method | 
| US6132580A              (en) | 1995-09-28 | 2000-10-17 | The Regents Of The University Of California | Miniature reaction chamber and devices incorporating same | 
| DE69513658T2              (en) | 1995-09-29 | 2000-05-31 | Stmicroelectronics S.R.L., Agrate Brianza | Voltage regulator for non-volatile, electrically programmable semiconductor memory devices | 
| US5651839A              (en) | 1995-10-26 | 1997-07-29 | Queen's University At Kingston | Process for engineering coherent twin and coincident site lattice grain boundaries in polycrystalline materials | 
| US5705813A              (en) | 1995-11-01 | 1998-01-06 | Hewlett-Packard Company | Integrated planar liquid handling system for maldi-TOF MS | 
| US20010055812A1              (en) | 1995-12-05 | 2001-12-27 | Alec Mian | Devices and method for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics | 
| USD382647S              (en) | 1996-01-17 | 1997-08-19 | Biomerieux Vitek, Inc. | Biochemical test card | 
| US5883211A              (en) | 1996-01-19 | 1999-03-16 | Aclara Biosciences, Inc. | Thermoreversible hydrogels comprising linear copolymers and their use in electrophoresis | 
| US5631337A              (en) | 1996-01-19 | 1997-05-20 | Soane Bioscience | Thermoreversible hydrogels comprising linear copolymers and their use in electrophoresis | 
| US5863502A              (en) | 1996-01-24 | 1999-01-26 | Sarnoff Corporation | Parallel reaction cassette and associated devices | 
| US5726944A              (en) | 1996-02-05 | 1998-03-10 | Motorola, Inc. | Voltage regulator for regulating an output voltage from a charge pump and method therefor | 
| US5981735A              (en) | 1996-02-12 | 1999-11-09 | Cobra Therapeutics Limited | Method of plasmid DNA production and purification | 
| USD378782S              (en) | 1996-03-01 | 1997-04-08 | Johnson & Johnson Clinical Diagnostics, Inc. | Processor for nucleic acid detection | 
| US5849598A              (en) | 1996-03-15 | 1998-12-15 | Washington University | Method for transferring micro quantities of liquid samples to discrete locations | 
| WO1997036166A1              (en) | 1996-03-25 | 1997-10-02 | Diasys Corporation | Apparatus and method for handling fluid samples of body materials | 
| US6114122A              (en) | 1996-03-26 | 2000-09-05 | Affymetrix, Inc. | Fluidics station with a mounting system and method of using | 
| US5844238A              (en) | 1996-03-27 | 1998-12-01 | David Sarnoff Research Center, Inc. | Infrared imager using room temperature capacitance sensor | 
| US7235406B1              (en) | 1996-04-03 | 2007-06-26 | Applera Corporation | Nucleic acid analysis device | 
| US5788814A              (en) | 1996-04-09 | 1998-08-04 | David Sarnoff Research Center | Chucks and methods for positioning multiple objects on a substrate | 
| US6399023B1              (en) | 1996-04-16 | 2002-06-04 | Caliper Technologies Corp. | Analytical system and method | 
| US5885470A              (en) | 1997-04-14 | 1999-03-23 | Caliper Technologies Corporation | Controlled fluid transport in microfabricated polymeric substrates | 
| US5942443A              (en) | 1996-06-28 | 1999-08-24 | Caliper Technologies Corporation | High throughput screening assay systems in microscale fluidic devices | 
| US5671303A              (en) | 1996-04-17 | 1997-09-23 | Motorola, Inc. | Molecular detection apparatus and method using optical waveguide detection | 
| US6001307A              (en) | 1996-04-26 | 1999-12-14 | Kyoto Daiichi Kagaku Co., Ltd. | Device for analyzing a sample | 
| US6054277A              (en) | 1996-05-08 | 2000-04-25 | Regents Of The University Of Minnesota | Integrated microchip genetic testing system | 
| WO1997044671A1              (en) | 1996-05-20 | 1997-11-27 | Precision System Science Co., Ltd. | Method and apparatus for controlling magnetic particles by pipetting machine | 
| US5726404A              (en) | 1996-05-31 | 1998-03-10 | University Of Washington | Valveless liquid microswitch | 
| US6083762A              (en) | 1996-05-31 | 2000-07-04 | Packard Instruments Company | Microvolume liquid handling system | 
| US5863801A              (en) | 1996-06-14 | 1999-01-26 | Sarnoff Corporation | Automated nucleic acid isolation | 
| US5912124A              (en) | 1996-06-14 | 1999-06-15 | Sarnoff Corporation | Padlock probe detection | 
| US5939291A              (en) | 1996-06-14 | 1999-08-17 | Sarnoff Corporation | Microfluidic method for nucleic acid amplification | 
| NZ333346A              (en) | 1996-06-28 | 2000-03-27 | Caliper Techn Corp | High-throughput screening assay systems in microscale fluidic devices | 
| AU726987B2              (en) | 1996-06-28 | 2000-11-30 | Caliper Life Sciences, Inc. | Electropipettor and compensation means for electrophoretic bias | 
| US5779868A              (en) | 1996-06-28 | 1998-07-14 | Caliper Technologies Corporation | Electropipettor and compensation means for electrophoretic bias | 
| US5800690A              (en) | 1996-07-03 | 1998-09-01 | Caliper Technologies Corporation | Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces | 
| US5699157A              (en) | 1996-07-16 | 1997-12-16 | Caliper Technologies Corp. | Fourier detection of species migrating in a microchannel | 
| US6074827A              (en) | 1996-07-30 | 2000-06-13 | Aclara Biosciences, Inc. | Microfluidic method for nucleic acid purification and processing | 
| US20020053399A1              (en) | 1996-07-30 | 2002-05-09 | Aclara Biosciences, Inc | Methods for fabricating enclosed microchannel structures | 
| US5804436A              (en) | 1996-08-02 | 1998-09-08 | Axiom Biotechnologies, Inc. | Apparatus and method for real-time measurement of cellular response | 
| US6280967B1              (en) | 1996-08-02 | 2001-08-28 | Axiom Biotechnologies, Inc. | Cell flow apparatus and method for real-time of cellular responses | 
| US6558916B2              (en) | 1996-08-02 | 2003-05-06 | Axiom Biotechnologies, Inc. | Cell flow apparatus and method for real-time measurements of patient cellular responses | 
| US5858187A              (en) | 1996-09-26 | 1999-01-12 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing electrodynamic focusing on a microchip | 
| US5872623A              (en) | 1996-09-26 | 1999-02-16 | Sarnoff Corporation | Massively parallel detection | 
| US6110343A              (en) | 1996-10-04 | 2000-08-29 | Lockheed Martin Energy Research Corporation | Material transport method and apparatus | 
| US6500390B1              (en) | 1996-10-17 | 2002-12-31 | David A. Boulton | Method for sealing and venting a microplate assembly | 
| US5874046A              (en) | 1996-10-30 | 1999-02-23 | Raytheon Company | Biological warfare agent sensor system employing ruthenium-terminated oligonucleotides complementary to target live agent DNA sequences | 
| US6133436A              (en) | 1996-11-06 | 2000-10-17 | Sequenom, Inc. | Beads bound to a solid support and to nucleic acids | 
| USD421653S              (en) | 1996-11-18 | 2000-03-14 | Tekmar Company | Housing for a laboratory instrument | 
| DE19749011A1              (en) | 1996-11-19 | 1998-05-20 | Lang Volker | Micro=valve for one time use has opening closed by plug mounted on resistance plate | 
| US6465257B1              (en) | 1996-11-19 | 2002-10-15 | Caliper Technologies Corp. | Microfluidic systems | 
| US6447727B1              (en) | 1996-11-19 | 2002-09-10 | Caliper Technologies Corp. | Microfluidic systems | 
| WO1998022625A1              (en) | 1996-11-20 | 1998-05-28 | The Regents Of The University Of Michigan | Microfabricated isothermal nucleic acid amplification devices and methods | 
| USD399959S              (en) | 1997-01-24 | 1998-10-20 | Abbott Laboratories | Housing for a device for measuring the concentration of an analyte in a sample of blood | 
| US5772966A              (en) | 1997-01-24 | 1998-06-30 | Maracas; George N. | Assay dispensing apparatus | 
| DE19707226A1              (en) | 1997-02-24 | 1998-08-27 | Bodenseewerk Perkin Elmer Co | Light scanner | 
| US5861563A              (en) | 1997-03-20 | 1999-01-19 | Bayer Corporation | Automatic closed tube sampler | 
| US5964997A              (en) | 1997-03-21 | 1999-10-12 | Sarnoff Corporation | Balanced asymmetric electronic pulse patterns for operating electrode-based pumps | 
| US5747666A              (en) | 1997-03-26 | 1998-05-05 | Willis; John P. | Point-of-care analyzer module | 
| US6391622B1              (en) | 1997-04-04 | 2002-05-21 | Caliper Technologies Corp. | Closed-loop biochemical analyzers | 
| US6235471B1              (en) | 1997-04-04 | 2001-05-22 | Caliper Technologies Corp. | Closed-loop biochemical analyzers | 
| US5964995A              (en) | 1997-04-04 | 1999-10-12 | Caliper Technologies Corp. | Methods and systems for enhanced fluid transport | 
| US5993750A              (en) | 1997-04-11 | 1999-11-30 | Eastman Kodak Company | Integrated ceramic micro-chemical plant | 
| DE19717085C2              (en) | 1997-04-23 | 1999-06-17 | Bruker Daltonik Gmbh | Processes and devices for extremely fast DNA multiplication using polymerase chain reactions (PCR) | 
| US5976336A              (en) | 1997-04-25 | 1999-11-02 | Caliper Technologies Corp. | Microfluidic devices incorporating improved channel geometries | 
| KR100351531B1              (en) | 1997-04-25 | 2002-09-11 | 캘리퍼 테크놀로지스 코포레이션 | Microfludic devices incorporating improved channel geometries | 
| US5997708A              (en) | 1997-04-30 | 1999-12-07 | Hewlett-Packard Company | Multilayer integrated assembly having specialized intermediary substrate | 
| US5980719A              (en) | 1997-05-13 | 1999-11-09 | Sarnoff Corporation | Electrohydrodynamic receptor | 
| US6106685A              (en) | 1997-05-13 | 2000-08-22 | Sarnoff Corporation | Electrode combinations for pumping fluids | 
| JP3469585B2              (en) | 1997-05-23 | 2003-11-25 | ガメラ  バイオサイエンス  コーポレイション | Apparatus and method for using centripetal acceleration to drive flow motion in microfluidics systems | 
| US5869004A              (en) | 1997-06-09 | 1999-02-09 | Caliper Technologies Corp. | Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems | 
| US6524790B1              (en) | 1997-06-09 | 2003-02-25 | Caliper Technologies Corp. | Apparatus and methods for correcting for variable velocity in microfluidic systems | 
| US6190619B1              (en) | 1997-06-11 | 2001-02-20 | Argonaut Technologies, Inc. | Systems and methods for parallel synthesis of compounds | 
| US6425972B1              (en) | 1997-06-18 | 2002-07-30 | Calipher Technologies Corp. | Methods of manufacturing microfabricated substrates | 
| US5882465A              (en) | 1997-06-18 | 1999-03-16 | Caliper Technologies Corp. | Method of manufacturing microfluidic devices | 
| US5900130A              (en) | 1997-06-18 | 1999-05-04 | Alcara Biosciences, Inc. | Method for sample injection in microchannel device | 
| US5959291A              (en) | 1997-06-27 | 1999-09-28 | Caliper Technologies Corporation | Method and apparatus for measuring low power signals | 
| US6001231A              (en) | 1997-07-15 | 1999-12-14 | Caliper Technologies Corp. | Methods and systems for monitoring and controlling fluid flow rates in microfluidic systems | 
| US5932799A              (en) | 1997-07-21 | 1999-08-03 | Ysi Incorporated | Microfluidic analyzer module | 
| US5827481A              (en) | 1997-07-31 | 1998-10-27 | Hewlett-Packard Company | Cartridge system for effecting sample acquisition and introduction | 
| US5876675A              (en) | 1997-08-05 | 1999-03-02 | Caliper Technologies Corp. | Microfluidic devices and systems | 
| US5916522A              (en) | 1997-08-07 | 1999-06-29 | Careside, Inc. | Electrochemical analytical cartridge | 
| US5919711A              (en) | 1997-08-07 | 1999-07-06 | Careside, Inc. | Analytical cartridge | 
| US6156199A              (en) | 1997-08-11 | 2000-12-05 | Zuk, Jr.; Peter | Centrifugal filtration apparatus | 
| US6368871B1              (en) | 1997-08-13 | 2002-04-09 | Cepheid | Non-planar microstructures for manipulation of fluid samples | 
| US5916776A              (en) | 1997-08-27 | 1999-06-29 | Sarnoff Corporation | Amplification method for a polynucleotide | 
| US5989402A              (en) | 1997-08-29 | 1999-11-23 | Caliper Technologies Corp. | Controller/detector interfaces for microfluidic systems | 
| US5965410A              (en) | 1997-09-02 | 1999-10-12 | Caliper Technologies Corp. | Electrical current for controlling fluid parameters in microchannels | 
| US6597450B1              (en) | 1997-09-15 | 2003-07-22 | Becton, Dickinson And Company | Automated Optical Reader for Nucleic Acid Assays | 
| US6284113B1              (en) | 1997-09-19 | 2001-09-04 | Aclara Biosciences, Inc. | Apparatus and method for transferring liquids | 
| US5961925A              (en) | 1997-09-22 | 1999-10-05 | Bristol-Myers Squibb Company | Apparatus for synthesis of multiple organic compounds with pinch valve block | 
| US5993611A              (en) | 1997-09-24 | 1999-11-30 | Sarnoff Corporation | Capacitive denaturation of nucleic acid | 
| US6012902A              (en) | 1997-09-25 | 2000-01-11 | Caliper Technologies Corp. | Micropump | 
| DE69839294T2              (en) | 1997-09-29 | 2009-04-09 | F. Hoffmann-La Roche Ag | Apparatus for depositing magnetic particles | 
| US6103537A              (en) | 1997-10-02 | 2000-08-15 | Aclara Biosciences, Inc. | Capillary assays involving separation of free and bound species | 
| US5842787A              (en) | 1997-10-09 | 1998-12-01 | Caliper Technologies Corporation | Microfluidic systems incorporating varied channel dimensions | 
| JP2001520377A              (en) | 1997-10-15 | 2001-10-30 | アクレイラ  バイオサイエンシズ,インコーポレイティド | Laminated micro structural device and method of manufacturing laminated micro structural device | 
| US5958694A              (en) | 1997-10-16 | 1999-09-28 | Caliper Technologies Corp. | Apparatus and methods for sequencing nucleic acids in microfluidic systems | 
| US6132684A              (en) | 1997-10-31 | 2000-10-17 | Becton Dickinson And Company | Sample tube holder | 
| DK1030736T3              (en) | 1997-11-14 | 2004-01-26 | Gen Probe Inc | Workstation for assays | 
| AU1460299A              (en) | 1997-11-14 | 1999-06-07 | California Institute Of Technology | Cell lysis device | 
| US5992820A              (en) | 1997-11-19 | 1999-11-30 | Sarnoff Corporation | Flow control in microfluidics devices by controlled bubble formation | 
| US6174675B1              (en) | 1997-11-25 | 2001-01-16 | Caliper Technologies Corp. | Electrical current for controlling fluid parameters in microchannels | 
| US6197503B1              (en) | 1997-11-26 | 2001-03-06 | Ut-Battelle, Llc | Integrated circuit biochip microsystem containing lens | 
| US6258264B1              (en) | 1998-04-10 | 2001-07-10 | Transgenomic, Inc. | Non-polar media for polynucleotide separations | 
| US6914137B2              (en) | 1997-12-06 | 2005-07-05 | Dna Research Innovations Limited | Isolation of nucleic acids | 
| US6074725A              (en) | 1997-12-10 | 2000-06-13 | Caliper Technologies Corp. | Fabrication of microfluidic circuits by printing techniques | 
| US5948227A              (en) | 1997-12-17 | 1999-09-07 | Caliper Technologies Corp. | Methods and systems for performing electrophoretic molecular separations | 
| EP1179585B1              (en) | 1997-12-24 | 2008-07-09 | Cepheid | Device and method for lysis | 
| US6430512B1              (en) | 1997-12-30 | 2002-08-06 | Caliper Technologies Corp. | Software for the display of chromatographic separation data | 
| US6167910B1              (en) | 1998-01-20 | 2001-01-02 | Caliper Technologies Corp. | Multi-layer microfluidic devices | 
| JP3551293B2              (en) | 1998-02-02 | 2004-08-04 | 東洋紡績株式会社 | Nucleic acid extraction device | 
| US6420143B1              (en) | 1998-02-13 | 2002-07-16 | Caliper Technologies Corp. | Methods and systems for performing superheated reactions in microscale fluidic systems | 
| US6100541A              (en) | 1998-02-24 | 2000-08-08 | Caliper Technologies Corporation | Microfluidic devices and systems incorporating integrated optical elements | 
| US6251343B1              (en) | 1998-02-24 | 2001-06-26 | Caliper Technologies Corp. | Microfluidic devices and systems incorporating cover layers | 
| US6861035B2              (en) | 1998-02-24 | 2005-03-01 | Aurora Discovery, Inc. | Multi-well platforms, caddies, lids and combinations thereof | 
| US6756019B1              (en) | 1998-02-24 | 2004-06-29 | Caliper Technologies Corp. | Microfluidic devices and systems incorporating cover layers | 
| US6024920A              (en) | 1998-04-21 | 2000-02-15 | Bio-Rad Laboratories, Inc. | Microplate scanning read head | 
| KR100704324B1              (en) | 1998-05-01 | 2007-04-09 | 젠-프로브 인코포레이티드 | Automated Analytical Instruments and Automated Analytical Methods | 
| US6123798A              (en) | 1998-05-06 | 2000-09-26 | Caliper Technologies Corp. | Methods of fabricating polymeric structures incorporating microscale fluidic elements | 
| EP0964555A1              (en) | 1998-06-04 | 1999-12-15 | Siemens Aktiengesellschaft | Threshold control and adaptive filtering in CAP receivers | 
| US6274089B1              (en) | 1998-06-08 | 2001-08-14 | Caliper Technologies Corp. | Microfluidic devices, systems and methods for performing integrated reactions and separations | 
| US6306590B1              (en) | 1998-06-08 | 2001-10-23 | Caliper Technologies Corp. | Microfluidic matrix localization apparatus and methods | 
| US7799521B2              (en) | 1998-06-24 | 2010-09-21 | Chen & Chen, Llc | Thermal cycling | 
| US6375901B1              (en) | 1998-06-29 | 2002-04-23 | Agilent Technologies, Inc. | Chemico-mechanical microvalve and devices comprising the same | 
| DE19833087A1              (en) | 1998-07-23 | 2000-01-27 | Bosch Gmbh Robert | Gas sensor for vehicle engine; has measuring electrode comprising platinum base with sintered porous layer and noble metal covering layer, applied in galvanic bath | 
| US6366924B1              (en) | 1998-07-27 | 2002-04-02 | Caliper Technologies Corp. | Distributed database for analytical instruments | 
| US6540896B1              (en) | 1998-08-05 | 2003-04-01 | Caliper Technologies Corp. | Open-Field serial to parallel converter | 
| US6958392B2              (en) | 1998-10-09 | 2005-10-25 | Whatman, Inc. | Methods for the isolation of nucleic acids and for quantitative DNA extraction and detection for leukocyte evaluation in blood products | 
| US6572830B1              (en) | 1998-10-09 | 2003-06-03 | Motorola, Inc. | Integrated multilayered microfludic devices and methods for making the same | 
| US6498497B1              (en) | 1998-10-14 | 2002-12-24 | Caliper Technologies Corp. | Microfluidic controller and detector system with self-calibration | 
| US6149787A              (en) | 1998-10-14 | 2000-11-21 | Caliper Technologies Corp. | External material accession systems and methods | 
| US6948843B2              (en) | 1998-10-28 | 2005-09-27 | Covaris, Inc. | Method and apparatus for acoustically controlling liquid solutions in microfluidic devices | 
| US6086740A              (en) | 1998-10-29 | 2000-07-11 | Caliper Technologies Corp. | Multiplexed microfluidic devices and systems | 
| US5973138A              (en) | 1998-10-30 | 1999-10-26 | Becton Dickinson And Company | Method for purification and manipulation of nucleic acids using paramagnetic particles | 
| WO2000034521A1              (en) | 1998-12-08 | 2000-06-15 | Boston Probes, Inc. | Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices | 
| US6062261A              (en) | 1998-12-16 | 2000-05-16 | Lockheed Martin Energy Research Corporation | MicrofluIdic circuit designs for performing electrokinetic manipulations that reduce the number of voltage sources and fluid reservoirs | 
| US6261431B1              (en) | 1998-12-28 | 2001-07-17 | Affymetrix, Inc. | Process for microfabrication of an integrated PCR-CE device and products produced by the same | 
| US6150119A              (en) | 1999-01-19 | 2000-11-21 | Caliper Technologies Corp. | Optimized high-throughput analytical system | 
| IT1306964B1              (en) | 1999-01-19 | 2001-10-11 | St Microelectronics Srl | CAPACITIVE BOOSTING CIRCUIT FOR REGULATION OF LINE VOLTAGE READING IN NON-VOLATILE MEMORIES | 
| US6416642B1              (en) | 1999-01-21 | 2002-07-09 | Caliper Technologies Corp. | Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection | 
| US20020019059A1              (en) | 1999-01-28 | 2002-02-14 | Calvin Y.H. Chow | Devices, systems and methods for time domain multiplexing of reagents | 
| CN1296703C              (en) | 1999-02-02 | 2007-01-24 | 卡钳生命科学股份有限公司 | Methods, devices and systems for identifying proteins | 
| US6294063B1              (en) | 1999-02-12 | 2001-09-25 | Board Of Regents, The University Of Texas System | Method and apparatus for programmable fluidic processing | 
| US6632655B1              (en) | 1999-02-23 | 2003-10-14 | Caliper Technologies Corp. | Manipulation of microparticles in microfluidic systems | 
| US6558945B1              (en) | 1999-03-08 | 2003-05-06 | Aclara Biosciences, Inc. | Method and device for rapid color detection | 
| US6171850B1              (en) | 1999-03-08 | 2001-01-09 | Caliper Technologies Corp. | Integrated devices and systems for performing temperature controlled reactions and analyses | 
| US6326083B1              (en) | 1999-03-08 | 2001-12-04 | Calipher Technologies Corp. | Surface coating for microfluidic devices that incorporate a biopolymer resistant moiety | 
| US6148508A              (en) | 1999-03-12 | 2000-11-21 | Caliper Technologies Corp. | Method of making a capillary for electrokinetic transport of materials | 
| US6783962B1              (en) | 1999-03-26 | 2004-08-31 | Upfront Chromatography | Particulate material for purification of bio-macromolecules | 
| US6500323B1              (en) | 1999-03-26 | 2002-12-31 | Caliper Technologies Corp. | Methods and software for designing microfluidic devices | 
| US6303343B1              (en) | 1999-04-06 | 2001-10-16 | Caliper Technologies Corp. | Inefficient fast PCR | 
| US6306273B1              (en) | 1999-04-13 | 2001-10-23 | Aclara Biosciences, Inc. | Methods and compositions for conducting processes in microfluidic devices | 
| US6322683B1              (en) | 1999-04-14 | 2001-11-27 | Caliper Technologies Corp. | Alignment of multicomponent microfabricated structures | 
| US20040053290A1              (en) | 2000-01-11 | 2004-03-18 | Terbrueggen Robert Henry | Devices and methods for biochip multiplexing | 
| US6942771B1              (en) | 1999-04-21 | 2005-09-13 | Clinical Micro Sensors, Inc. | Microfluidic systems in the electrochemical detection of target analytes | 
| CA2270106C              (en) | 1999-04-23 | 2006-03-14 | Yousef Haj-Ahmad | Nucleic acid purification and process | 
| US6773676B2              (en) | 1999-04-27 | 2004-08-10 | Agilent Technologies, Inc. | Devices for performing array hybridization assays and methods of using the same | 
| JP4647792B2              (en) | 1999-04-28 | 2011-03-09 | イジュノシッヒ  テクニッヒ  ホッフシューラ  チューリッヒ | Polyionic coatings in analytical and sensing devices | 
| US6555389B1              (en) | 1999-05-11 | 2003-04-29 | Aclara Biosciences, Inc. | Sample evaporative control | 
| US6458259B1              (en) | 1999-05-11 | 2002-10-01 | Caliper Technologies Corp. | Prevention of surface adsorption in microchannels by application of electric current during pressure-induced flow | 
| US6399952B1              (en) | 1999-05-12 | 2002-06-04 | Aclara Biosciences, Inc. | Multiplexed fluorescent detection in microfluidic devices | 
| US6838680B2              (en) | 1999-05-12 | 2005-01-04 | Aclara Biosciences, Inc. | Multiplexed fluorescent detection in microfluidic devices | 
| US6592821B1              (en) | 1999-05-17 | 2003-07-15 | Caliper Technologies Corp. | Focusing of microparticles in microfluidic systems | 
| WO2000070080A1              (en) | 1999-05-17 | 2000-11-23 | Caliper Technologies Corp. | Focusing of microparticles in microfluidic systems | 
| US6472141B2              (en) | 1999-05-21 | 2002-10-29 | Caliper Technologies Corp. | Kinase assays using polycations | 
| US6287774B1              (en) | 1999-05-21 | 2001-09-11 | Caliper Technologies Corp. | Assay methods and system | 
| EP1180135B1              (en) | 1999-05-28 | 2005-08-17 | Cepheid | Apparatus and method for cell disruption | 
| DE60039529D1              (en) | 1999-05-28 | 2008-08-28 | Bio Data Corp | METHOD AND DEVICE FOR DIRECTLY SAMPLING A FLUID FOR MICROFILTRATION | 
| AU5291600A              (en) | 1999-06-01 | 2000-12-18 | Caliper Technologies Corporation | Microscale assays and microfluidic devices for transporter, gradient induced, and binding activities | 
| US6811668B1              (en) | 1999-06-22 | 2004-11-02 | Caliper Life Sciences, Inc. | Apparatus for the operation of a microfluidic device | 
| US6706519B1              (en) | 1999-06-22 | 2004-03-16 | Tecan Trading Ag | Devices and methods for the performance of miniaturized in vitro amplification assays | 
| FR2795426A1              (en) | 1999-06-22 | 2000-12-29 | Commissariat Energie Atomique | Support for genetic analysis comprising reservoir(s) for a medium to be analyzed connected by passage(s) having temperature control device(s) to a test strip with analysis sites having biological probes | 
| US6878540B2              (en) | 1999-06-25 | 2005-04-12 | Cepheid | Device for lysing cells, spores, or microorganisms | 
| DK1065378T3              (en) | 1999-06-28 | 2002-07-29 | California Inst Of Techn | Elastomeric micropump and micro valve systems | 
| WO2001002850A1              (en) | 1999-07-06 | 2001-01-11 | Caliper Technologies Corp. | Microfluidic systems and methods for determining modulator kinetics | 
| US6353475B1              (en) | 1999-07-12 | 2002-03-05 | Caliper Technologies Corp. | Light source power modulation for use with chemical and biochemical analysis | 
| USD438311S1              (en) | 1999-07-28 | 2001-02-27 | Matsushita Electric Industrial Co.,Ltd. | Strip for blood test | 
| US6337435B1              (en) | 1999-07-30 | 2002-01-08 | Bio-Rad Laboratories, Inc. | Temperature control for multi-vessel reaction apparatus | 
| US6524456B1              (en) | 1999-08-12 | 2003-02-25 | Ut-Battelle, Llc | Microfluidic devices for the controlled manipulation of small volumes | 
| US6495104B1              (en) | 1999-08-19 | 2002-12-17 | Caliper Technologies Corp. | Indicator components for microfluidic systems | 
| US6858185B1              (en) | 1999-08-25 | 2005-02-22 | Caliper Life Sciences, Inc. | Dilutions in high throughput systems with a single vacuum source | 
| US6613581B1              (en) | 1999-08-26 | 2003-09-02 | Caliper Technologies Corp. | Microfluidic analytic detection assays, devices, and integrated systems | 
| US6824663B1              (en) | 1999-08-27 | 2004-11-30 | Aclara Biosciences, Inc. | Efficient compound distribution in microfluidic devices | 
| US6613211B1              (en) | 1999-08-27 | 2003-09-02 | Aclara Biosciences, Inc. | Capillary electrokinesis based cellular assays | 
| AU7101000A              (en) | 1999-09-10 | 2001-04-10 | Caliper Technologies Corporation | Microfabrication methods and devices | 
| US6906797B1              (en) | 1999-09-13 | 2005-06-14 | Aclara Biosciences, Inc. | Side light activated microfluid channels | 
| DE19945604A1              (en) | 1999-09-23 | 2003-08-07 | Aclara Biosciences Inc | Method of joining workpieces made of plastic and its use in microstructure and nanostructure technology | 
| US6221600B1              (en) | 1999-10-08 | 2001-04-24 | Board Of Regents, The University Of Texas System | Combinatorial oligonucleotide PCR: a method for rapid, global expression analysis | 
| CA2385618A1              (en) | 1999-10-08 | 2001-04-19 | Caliper Technologies Corporation | Use of nernstein voltage sensitive dyes in measuring transmembrane voltage | 
| US6287254B1              (en) | 1999-11-02 | 2001-09-11 | W. Jean Dodds | Animal health diagnosis | 
| US6908594B1              (en) | 1999-10-22 | 2005-06-21 | Aclara Biosciences, Inc. | Efficient microfluidic sealing | 
| USD461906S1              (en) | 1999-10-25 | 2002-08-20 | Tuan Hung Pham | Diagnostic test card | 
| USD438632S1              (en) | 1999-12-21 | 2001-03-06 | Compucyte Corporation | Multi-well reagent cartridge for treating a sample | 
| USD438633S1              (en) | 1999-12-21 | 2001-03-06 | Compucyte Corporation | Reagent cartridge for treating a sample | 
| AU2610201A              (en) | 2000-01-06 | 2001-07-16 | Caliper Technologies Corporation | Ultra high throughput sampling and analysis systems and methods | 
| WO2001049874A1              (en) | 2000-01-06 | 2001-07-12 | Caliper Technologies Corp. | Methods and systems for monitoring intracellular binding reactions | 
| US6468761B2              (en) | 2000-01-07 | 2002-10-22 | Caliper Technologies, Corp. | Microfluidic in-line labeling method for continuous-flow protease inhibition analysis | 
| WO2001051918A1              (en) | 2000-01-12 | 2001-07-19 | Ut-Battelle, Llc | A microfluidic device and method for focusing, segmenting, and dispensing of a fluid stream | 
| US7037416B2              (en) | 2000-01-14 | 2006-05-02 | Caliper Life Sciences, Inc. | Method for monitoring flow rate using fluorescent markers | 
| US6556923B2              (en) | 2000-01-26 | 2003-04-29 | Caliper Technologies Corp. | Software for high throughput microfluidic systems | 
| US6589729B2              (en) | 2000-02-04 | 2003-07-08 | Caliper Technologies Corp. | Methods, devices, and systems for monitoring time dependent reactions | 
| WO2001059440A2              (en) | 2000-02-11 | 2001-08-16 | Aclara Biosciences Inc. | Microfluid device with sample injector and method of use | 
| US6685813B2              (en) | 2000-02-11 | 2004-02-03 | Aclara Biosciences, Inc. | Tandem isotachophoresis/zone electrophoresis method and system | 
| US7332271B2              (en) | 2000-02-18 | 2008-02-19 | Board Of Trustees Of The Leland Stanford Junior University | Apparatus and methods for parallel processing of micro-volume liquid reactions | 
| US6681616B2              (en) | 2000-02-23 | 2004-01-27 | Caliper Technologies Corp. | Microfluidic viscometer | 
| IL151122A0              (en) | 2000-02-23 | 2003-04-10 | Caliper Techn Corp | Multi-reservoir pressure control system | 
| US7040144B2              (en) | 2000-02-23 | 2006-05-09 | Caliper Life Sciences, Inc. | Microfluidic viscometer | 
| US6730206B2              (en) | 2000-03-17 | 2004-05-04 | Aclara Biosciences, Inc. | Microfluidic device and system with improved sample handling | 
| US20020012971A1              (en) | 2000-03-20 | 2002-01-31 | Mehta Tammy Burd | PCR compatible nucleic acid sieving medium | 
| US6358387B1              (en) | 2000-03-27 | 2002-03-19 | Caliper Technologies Corporation | Ultra high throughput microfluidic analytical systems and methods | 
| US6927851B2              (en) | 2000-03-31 | 2005-08-09 | Neogen Corporation | Methods and apparatus to improve the sensitivity and reproducibility of bioluminescent analytical methods | 
| US7867763B2              (en) | 2004-01-25 | 2011-01-11 | Fluidigm Corporation | Integrated chip carriers with thermocycler interfaces and methods of using the same | 
| US6733645B1              (en) | 2000-04-18 | 2004-05-11 | Caliper Technologies Corp. | Total analyte quantitation | 
| USD446306S1              (en) | 2000-04-26 | 2001-08-07 | Matsushita Electric Industrial Co., Ltd. | Medical information communication apparatus | 
| US6787016B2              (en) | 2000-05-01 | 2004-09-07 | Aclara Biosciences, Inc. | Dynamic coating with linear polymer mixture for electrophoresis | 
| EP1279071B1              (en) | 2000-05-03 | 2011-03-23 | Caliper Life Sciences, Inc. | Multi depth substrate fabrication processes | 
| AU6154101A              (en) | 2000-05-11 | 2001-11-20 | Caliper Techn Corp | Microfluidic devices and methods to regulate hydrodynamic and electrical resistance utilizing bulk viscosity enhancers | 
| AU2001261523B2              (en) | 2000-05-12 | 2005-11-17 | Caliper Life Sciences, Inc. | Detection of nucleic acid hybridization by fluorescence polarization | 
| DE60134849D1              (en) | 2000-05-19 | 2008-08-28 | Aclara Biosciences Inc | ORIENTATION OF AN OPTICAL DETECTION SYSTEM WITH A CAPILLARY CHANNEL IN A MICROFLUID LABORATORY CHIP | 
| US6520197B2              (en) | 2000-06-02 | 2003-02-18 | The Regents Of The University Of California | Continuous laminar fluid mixing in micro-electromechanical systems | 
| US7351376B1              (en) | 2000-06-05 | 2008-04-01 | California Institute Of Technology | Integrated active flux microfluidic devices and methods | 
| ATE304174T1              (en) | 2000-06-14 | 2005-09-15 | Univ Texas | SYSTEMS AND METHODS FOR CELL PART POPULATION ANALYSIS | 
| AU2001269929B2              (en) | 2000-06-19 | 2005-11-03 | Caliper Life Sciences, Inc. | Methods and devices for enhancing bonded substrate yields and regulating temperature | 
| US6720187B2              (en) | 2000-06-28 | 2004-04-13 | 3M Innovative Properties Company | Multi-format sample processing devices | 
| US7169618B2              (en) | 2000-06-28 | 2007-01-30 | Skold Technology | Magnetic particles and methods of producing coated magnetic particles | 
| US6734401B2              (en) | 2000-06-28 | 2004-05-11 | 3M Innovative Properties Company | Enhanced sample processing devices, systems and methods | 
| EP1305615B1              (en) | 2000-07-21 | 2004-09-29 | Aclara BioSciences, Inc. | Method and devices for capillary electrophoresis with a norbornene based surface coating | 
| US7004184B2              (en) | 2000-07-24 | 2006-02-28 | The Reagents Of The University Of Michigan | Compositions and methods for liquid metering in microchannels | 
| AU8095101A              (en) | 2000-08-02 | 2002-02-13 | Caliper Techn Corp | High throughput separations based analysis systems | 
| US20020142618A1              (en) | 2000-08-04 | 2002-10-03 | Caliper Technologies Corp. | Control of operation conditions within fluidic systems | 
| FR2813207B1              (en) | 2000-08-28 | 2002-10-11 | Bio Merieux | REACTIONAL CARD AND USE OF SUCH A CARD | 
| DE60140553D1              (en) | 2000-09-14 | 2009-12-31 | Caliper Life Sciences Inc | MICROFLUIDIC DEVICES AND METHODS FOR CARRYING OUT TEMPERATURE-MEDIATED REACTIONS | 
| US6939451B2              (en) | 2000-09-19 | 2005-09-06 | Aclara Biosciences, Inc. | Microfluidic chip having integrated electrodes | 
| US6623860B2              (en) | 2000-10-10 | 2003-09-23 | Aclara Biosciences, Inc. | Multilevel flow structures | 
| USD463031S1              (en) | 2000-10-11 | 2002-09-17 | Aclara Biosciences, Inc. | Microvolume sample plate | 
| US6375185B1              (en) | 2000-10-20 | 2002-04-23 | Gamemax Corporation | Paper currency receiving control assembly for currency-coin exchange machine | 
| US7514046B2              (en) | 2000-10-31 | 2009-04-07 | Caliper Life Sciences, Inc. | Methods and systems for processing microscale devices for reuse | 
| DE60138824D1              (en) | 2000-10-31 | 2009-07-09 | Caliper Life Sciences Inc | MICROFLUIDIC PROCESS FOR IN-SITU MATERIAL CONCENTRATION | 
| US7105304B1              (en) | 2000-11-07 | 2006-09-12 | Caliper Life Sciences, Inc. | Pressure-based mobility shift assays | 
| US20050202470A1              (en) | 2000-11-16 | 2005-09-15 | Caliper Life Sciences, Inc. | Binding assays using molecular melt curves | 
| US8900811B2              (en) | 2000-11-16 | 2014-12-02 | Caliper Life Sciences, Inc. | Method and apparatus for generating thermal melting curves in a microfluidic device | 
| USD468437S1              (en) | 2000-11-21 | 2003-01-07 | Acon Laboratories, Inc. | Test platform | 
| US6521188B1              (en) | 2000-11-22 | 2003-02-18 | Industrial Technology Research Institute | Microfluidic actuator | 
| US7024281B1              (en) | 2000-12-11 | 2006-04-04 | Callper Life Sciences, Inc. | Software for the controlled sampling of arrayed materials | 
| US6453928B1              (en) | 2001-01-08 | 2002-09-24 | Nanolab Ltd. | Apparatus, and method for propelling fluids | 
| US6878755B2              (en) | 2001-01-22 | 2005-04-12 | Microgen Systems, Inc. | Automated microfabrication-based biodetector | 
| US6681788B2              (en) | 2001-01-29 | 2004-01-27 | Caliper Technologies Corp. | Non-mechanical valves for fluidic systems | 
| US6692700B2              (en) | 2001-02-14 | 2004-02-17 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices | 
| US7670559B2              (en) | 2001-02-15 | 2010-03-02 | Caliper Life Sciences, Inc. | Microfluidic systems with enhanced detection systems | 
| US6720148B1              (en) | 2001-02-22 | 2004-04-13 | Caliper Life Sciences, Inc. | Methods and systems for identifying nucleotides by primer extension | 
| US7867776B2              (en) | 2001-03-02 | 2011-01-11 | Caliper Life Sciences, Inc. | Priming module for microfluidic chips | 
| US7150999B1              (en) | 2001-03-09 | 2006-12-19 | Califer Life Sciences, Inc. | Process for filling microfluidic channels | 
| US6576459B2              (en) | 2001-03-23 | 2003-06-10 | The Regents Of The University Of California | Sample preparation and detection device for infectious agents | 
| US7270786B2              (en) | 2001-03-28 | 2007-09-18 | Handylab, Inc. | Methods and systems for processing microfluidic samples of particle containing fluids | 
| US7323140B2              (en) | 2001-03-28 | 2008-01-29 | Handylab, Inc. | Moving microdroplets in a microfluidic device | 
| US6852287B2              (en) | 2001-09-12 | 2005-02-08 | Handylab, Inc. | Microfluidic devices having a reduced number of input and output connections | 
| US7010391B2              (en) | 2001-03-28 | 2006-03-07 | Handylab, Inc. | Methods and systems for control of microfluidic devices | 
| US7192557B2              (en) | 2001-03-28 | 2007-03-20 | Handylab, Inc. | Methods and systems for releasing intracellular material from cells within microfluidic samples of fluids | 
| US7829025B2              (en) | 2001-03-28 | 2010-11-09 | Venture Lending & Leasing Iv, Inc. | Systems and methods for thermal actuation of microfluidic devices | 
| US6575188B2              (en) | 2001-07-26 | 2003-06-10 | Handylab, Inc. | Methods and systems for fluid control in microfluidic devices | 
| US20020143297A1              (en) | 2001-03-30 | 2002-10-03 | Becton, Dickinson And Company | Adaptor for use with point-of-care testing cartridge | 
| USD470595S1              (en) | 2001-04-10 | 2003-02-18 | Andrea Crisanti | Assay device | 
| USD500142S1              (en) | 2001-04-10 | 2004-12-21 | Andrea Crisanti | Assay device | 
| US7440684B2              (en) | 2001-04-12 | 2008-10-21 | Spaid Michael A | Method and apparatus for improved temperature control in microfluidic devices | 
| US6588625B2              (en) | 2001-04-24 | 2003-07-08 | Abbott Laboratories | Sample handling system | 
| USD495805S1              (en) | 2001-05-25 | 2004-09-07 | Umedik, Inc. | Assay device | 
| US7723123B1              (en) | 2001-06-05 | 2010-05-25 | Caliper Life Sciences, Inc. | Western blot by incorporating an affinity purification zone | 
| US20020187557A1              (en) | 2001-06-07 | 2002-12-12 | Hobbs Steven E. | Systems and methods for introducing samples into microfluidic devices | 
| US7041068B2              (en) | 2001-06-12 | 2006-05-09 | Pelikan Technologies, Inc. | Sampling module device and method | 
| US6977163B1              (en) | 2001-06-13 | 2005-12-20 | Caliper Life Sciences, Inc. | Methods and systems for performing multiple reactions by interfacial mixing | 
| US6859698B2              (en) | 2001-06-21 | 2005-02-22 | Snap-On Incorporated | Detachable cartridge unit and auxiliary unit for function expansion of a data processing system | 
| US20030211517A1              (en) | 2001-06-22 | 2003-11-13 | Carulli John P. | Gp354 nucleic acids and polypeptides | 
| WO2003006964A1              (en) | 2001-07-12 | 2003-01-23 | Aclara Biosciences, Inc. | Submersible light-directing member for material excitation in microfluidic devices | 
| EP1952886B1              (en) | 2001-07-16 | 2021-06-23 | BioFire Defense, LLC | Thermal cycling system and method of use | 
| US7023007B2              (en) | 2001-07-17 | 2006-04-04 | Caliper Life Sciences, Inc. | Methods and systems for alignment of detection optics | 
| US6766817B2              (en) | 2001-07-25 | 2004-07-27 | Tubarc Technologies, Llc | Fluid conduction utilizing a reversible unsaturated siphon with tubarc porosity action | 
| US20060062696A1              (en) | 2001-07-27 | 2006-03-23 | Caliper Life Sciences, Inc. | Optimized high throughput analytical systems | 
| US7060171B1              (en) | 2001-07-31 | 2006-06-13 | Caliper Life Sciences, Inc. | Methods and systems for reducing background signal in assays | 
| USD482796S1              (en) | 2001-09-11 | 2003-11-25 | Sysmex Corporation | Sample analyzer | 
| USD512155S1              (en) | 2001-09-12 | 2005-11-29 | Techno Medica Co., Ltd. | Automatic blood sampling tube preparation apparatus | 
| USD467349S1              (en) | 2001-09-28 | 2002-12-17 | Orasure Technologies, Inc. | Analyzer | 
| USD467348S1              (en) | 2001-10-15 | 2002-12-17 | Kimberly-Clark Worldwide, Inc. | Diagnostic test carrier | 
| US7220345B2              (en) | 2001-10-18 | 2007-05-22 | The Board Of Trustees Of The University Of Illinois | Hybrid microfluidic and nanofluidic system | 
| US7338760B2              (en) | 2001-10-26 | 2008-03-04 | Ntu Ventures Private Limited | Sample preparation integrated chip | 
| US6750661B2              (en) | 2001-11-13 | 2004-06-15 | Caliper Life Sciences, Inc. | Method and apparatus for controllably effecting samples using two signals | 
| US7247274B1              (en) | 2001-11-13 | 2007-07-24 | Caliper Technologies Corp. | Prevention of precipitate blockage in microfluidic channels | 
| US7069952B1              (en) | 2001-11-14 | 2006-07-04 | Caliper Life Sciences, Inc. | Microfluidic devices and methods of their manufacture | 
| US7635588B2              (en) | 2001-11-29 | 2009-12-22 | Applied Biosystems, Llc | Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength | 
| JP4355210B2              (en) | 2001-11-30 | 2009-10-28 | フルイディグム  コーポレイション | Microfluidic device and method of using microfluidic device | 
| US6960235B2              (en) | 2001-12-05 | 2005-11-01 | The Regents Of The University Of California | Chemical microreactor and method thereof | 
| US20030127327A1              (en) | 2002-01-04 | 2003-07-10 | Kurnik Ronald T. | Microfluidic device and method for improved sample handling | 
| US7410615B2              (en) | 2002-01-24 | 2008-08-12 | Perkinelmer Las, Inc. | Precision liquid dispensing system | 
| US6819027B2              (en) | 2002-03-04 | 2004-11-16 | Cepheid | Method and apparatus for controlling ultrasonic transducer | 
| EP1485191B1              (en) | 2002-03-05 | 2012-08-01 | Caliper Life Sciences, Inc. | Mixed mode microfluidic system and method | 
| US7101467B2              (en) | 2002-03-05 | 2006-09-05 | Caliper Life Sciences, Inc. | Mixed mode microfluidic systems | 
| US7303727B1              (en) | 2002-03-06 | 2007-12-04 | Caliper Life Sciences, Inc | Microfluidic sample delivery devices, systems, and methods | 
| US7195986B1              (en) | 2002-03-08 | 2007-03-27 | Caliper Life Sciences, Inc. | Microfluidic device with controlled substrate conductivity | 
| US7252928B1              (en) | 2002-03-12 | 2007-08-07 | Caliper Life Sciences, Inc. | Methods for prevention of surface adsorption of biological materials to capillary walls in microchannels | 
| US7312085B2              (en) | 2002-04-01 | 2007-12-25 | Fluidigm Corporation | Microfluidic particle-analysis systems | 
| JP2006509996A              (en) | 2002-04-02 | 2006-03-23 | カリパー・ライフ・サイエンシズ・インコーポレーテッド | Method, system and apparatus for separating and isolating one or more sample components of a sample biomaterial | 
| USD472324S1              (en) | 2002-04-05 | 2003-03-25 | Charles River Laboratories, Inc. | Cuvette | 
| AU2003228514A1              (en) | 2002-04-11 | 2003-10-27 | Sequenom, Inc. | Methods and devices for performing chemical reactions on a solid support | 
| US8241883B2              (en) | 2002-04-24 | 2012-08-14 | Caliper Life Sciences, Inc. | High throughput mobility shift | 
| US6905612B2              (en) | 2003-03-21 | 2005-06-14 | Hanuman Llc | Plasma concentrate apparatus and method | 
| USD474279S1              (en) | 2002-05-15 | 2003-05-06 | Monogen, Inc. | Specimen processing instrument | 
| US7161356B1              (en) | 2002-06-05 | 2007-01-09 | Caliper Life Sciences, Inc. | Voltage/current testing equipment for microfluidic devices | 
| USD480814S1              (en) | 2002-06-11 | 2003-10-14 | Diversa Corporation | Gigamatrix holding tray | 
| US7208125B1              (en) | 2002-06-28 | 2007-04-24 | Caliper Life Sciences, Inc | Methods and apparatus for minimizing evaporation of sample materials from multiwell plates | 
| AU2003249231A1              (en) | 2002-07-15 | 2004-02-02 | Phynexus, Inc. | Low dead volume extraction column devices | 
| US20040053315A1              (en) | 2002-08-12 | 2004-03-18 | Caliper Technologies Corp. | Methods and systems for monitoring molecular interactions | 
| US7001853B1              (en) | 2002-08-30 | 2006-02-21 | Caliper Life Sciences, Inc. | Flow control of photo-polymerizable resin | 
| USD516221S1              (en) | 2002-09-09 | 2006-02-28 | Meso Scale Technologies, Llc. | Diagnostic instrument | 
| TW590982B              (en) | 2002-09-27 | 2004-06-11 | Agnitio Science & Technology I | Micro-fluid driving device | 
| US7122384B2              (en) | 2002-11-06 | 2006-10-17 | E. I. Du Pont De Nemours And Company | Resonant light scattering microparticle methods | 
| EP1567638A1              (en) | 2002-11-08 | 2005-08-31 | Irm, Llc | Apparatus and methods to process substrate surface features | 
| JP2004170159A              (en) | 2002-11-18 | 2004-06-17 | Hitachi Koki Co Ltd | Automatic dispensing device | 
| USD491276S1              (en) | 2002-12-09 | 2004-06-08 | Babette Langille | Plastic diagnostic card | 
| USD491272S1              (en) | 2002-12-13 | 2004-06-08 | Immunivest Corporation | Autoprep instrument | 
| WO2004055492A2              (en) | 2002-12-13 | 2004-07-01 | Aclara Biosciences, Inc. | Closed-loop control of electrokinetic processes in microfludic devices based on optical readings | 
| USD491273S1              (en) | 2002-12-19 | 2004-06-08 | 3M Innovative Properties Company | Hybridization cartridge | 
| US20050042639A1              (en) | 2002-12-20 | 2005-02-24 | Caliper Life Sciences, Inc. | Single molecule amplification and detection of DNA length | 
| WO2004083443A1              (en) | 2002-12-20 | 2004-09-30 | Caliper Life Sciences, Inc. | Single molecule amplification and detection of dna | 
| US7850912B2              (en) | 2003-05-14 | 2010-12-14 | Dako Denmark A/S | Method and apparatus for automated pre-treatment and processing of biological samples | 
| US20060094108A1              (en) | 2002-12-20 | 2006-05-04 | Karl Yoder | Thermal cycler for microfluidic array assays | 
| CA2511389C              (en) | 2002-12-26 | 2016-10-18 | Meso Scale Technologies, Llc. | Assay cartridges and methods of using the same | 
| US20060113190A1              (en) | 2002-12-27 | 2006-06-01 | Kurnik Ronald T | Microfluidic device and method for improved sample handling | 
| AU2003303594A1              (en) | 2002-12-30 | 2004-07-29 | The Regents Of The University Of California | Methods and apparatus for pathogen detection and analysis | 
| US20070269891A9              (en) | 2003-01-13 | 2007-11-22 | Yasunobu Tanaka | Solid surface with immobilized degradable cationic polymer for transfecting eukaryotic cells | 
| US7419638B2              (en) | 2003-01-14 | 2008-09-02 | Micronics, Inc. | Microfluidic devices for fluid manipulation and analysis | 
| US6964747B2              (en) | 2003-01-21 | 2005-11-15 | Bioarray Solutions, Ltd. | Production of dyed polymer microparticles | 
| JP4021335B2              (en) | 2003-01-31 | 2007-12-12 | ユニバーサル・バイオ・リサーチ株式会社 | Dispensing device with monitoring function and method for monitoring dispensing device | 
| US7338637B2              (en) | 2003-01-31 | 2008-03-04 | Hewlett-Packard Development Company, L.P. | Microfluidic device with thin-film electronic devices | 
| JP4632262B2              (en) | 2003-02-05 | 2011-02-16 | アイキューム,インク. | Sample processing | 
| US20040157220A1              (en) | 2003-02-10 | 2004-08-12 | Purnima Kurnool | Methods and apparatus for sample tracking | 
| AU2004230592B2              (en) | 2003-04-14 | 2007-10-04 | Caliper Life Sciences, Inc. | Reduction of migration shift assay interference | 
| GB2401237A              (en) | 2003-04-28 | 2004-11-03 | Hewlett Packard Development Co | Data transfer arrangement for disaster recovery | 
| US7148043B2              (en) | 2003-05-08 | 2006-12-12 | Bio-Rad Laboratories, Inc. | Systems and methods for fluorescence detection with a movable detection module | 
| US7595197B2              (en) | 2003-05-09 | 2009-09-29 | Caliper Life Sciences, Inc. | Automated sample analysis | 
| US7038472B1              (en) | 2003-05-12 | 2006-05-02 | Caliper Life Sciences, Inc. | Methods and systems for measuring internal dimensions of microscale structures | 
| US7374949B2              (en) | 2003-05-29 | 2008-05-20 | Bayer Healthcare Llc | Diagnostic test strip for collecting and detecting an analyte in a fluid sample | 
| US7055695B2              (en) | 2003-06-02 | 2006-06-06 | Caliper Life Sciencee, Inc. | Container providing a controlled hydrated environment | 
| EP1648622A4              (en) | 2003-07-21 | 2009-11-11 | Dendritic Nanotechnologies Inc | Stabilized and chemically functionalized nanoparticles | 
| USD508999S1              (en) | 2003-07-24 | 2005-08-30 | Biomerieux, Inc. | Sample testing machine | 
| US7744817B2              (en) | 2003-08-11 | 2010-06-29 | Sakura Finetek U.S.A., Inc. | Manifold assembly | 
| USD499813S1              (en) | 2003-08-22 | 2004-12-14 | As.Pire Bioresearch Inc. | Assay testing device | 
| JP2005065607A              (en) | 2003-08-26 | 2005-03-17 | Hitachi Ltd | Gene processing chip and gene processing apparatus | 
| USD515707S1              (en) | 2003-09-01 | 2006-02-21 | Matsushita Electric Industrial Co., Ltd. | Fluorescent reader | 
| RU2006110931A              (en) | 2003-09-05 | 2007-10-20 | Кайлипер Лайф Сайенсиз, Инк. (Us) | ANALYZED SUBSTANCE INJECTION SYSTEM | 
| EP1677666A2              (en) | 2003-09-19 | 2006-07-12 | University of Rochester | Diagnostic system for otolaryngologic pathogens and use thereof | 
| US20050220675A1              (en) | 2003-09-19 | 2005-10-06 | Reed Mark T | High density plate filler | 
| USD528215S1              (en) | 2003-09-30 | 2006-09-12 | Biacore Ab | Chip carrier for biosensor | 
| US7039527B2              (en) | 2003-10-01 | 2006-05-02 | Caliper Life Sciences, Inc. | Method for measuring diffusivities of compounds using microchips | 
| EP2264191A1              (en) | 2003-11-21 | 2010-12-22 | ANP Technologies, Inc. | Asymmetrically branched polymer conjugates and microarray assays | 
| WO2005068993A1              (en) | 2003-12-23 | 2005-07-28 | Caliper Life Sciences, Inc. | Analyte injection system | 
| US7099778B2              (en) | 2003-12-30 | 2006-08-29 | Caliper Life Sciences, Inc. | Method for determining diffusivity and molecular weight in a microfluidic device | 
| TWD106277S1              (en) | 2004-03-05 | 2005-09-01 | 精工愛普生股份有限公司 | Film scanner | 
| JP2007529753A              (en) | 2004-03-19 | 2007-10-25 | エスピール・カハット | A device for aspirating, manipulating, mixing, and dispensing nano-sized liquids | 
| ZA200609269B              (en) | 2004-04-09 | 2008-06-25 | Res Think Tank Inc | Devices and methods for collection, storage and transportation of biological specimens | 
| CA2994321C              (en) | 2004-05-03 | 2023-08-08 | Handylab, Inc. | A microfluidic device and methods for processing polynucleotide-containing samples | 
| US8852862B2              (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples | 
| US8496875B2              (en) | 2004-05-21 | 2013-07-30 | Caliper Life Sciences, Inc. | Automated system for handling microfluidic devices | 
| US7553671B2              (en) | 2004-05-25 | 2009-06-30 | Vertex Pharmaceuticals, Inc. | Modular test tube rack | 
| US8965710B2              (en) | 2004-07-02 | 2015-02-24 | The United States Of America, As Represented By The Secretary Of The Navy | Automated sample-to-microarray apparatus and method | 
| USD523153S1              (en) | 2004-07-23 | 2006-06-13 | Hitachi High-Technologies Corporation | Main part for immunity analysis machine | 
| EP1621890A1              (en) | 2004-07-26 | 2006-02-01 | bioMerieux B.V. | Device and method for separating, mixing and concentrating magnetic particles with a fluid and use thereof in purification methods | 
| KR100668304B1              (en) | 2004-09-16 | 2007-01-12 | 삼성전자주식회사 | Apparatus for injecting a mixed solution of PCR into each PCR channel of the PCR chip and the PCR chip unit including the apparatus | 
| USD548841S1              (en) | 2004-10-15 | 2007-08-14 | Microsulis, Ltd | Electrical equipment for ablative treatment | 
| US7727477B2              (en) | 2004-12-10 | 2010-06-01 | Bio-Rad Laboratories, Inc. | Apparatus for priming microfluidics devices with feedback control | 
| US20060165558A1              (en) | 2004-12-21 | 2006-07-27 | Thomas Witty | Cartridge for diagnostic assays | 
| US20060183216A1              (en) | 2005-01-21 | 2006-08-17 | Kalyan Handique | Containers for liquid storage and delivery with application to microfluidic devices | 
| CN101163800B              (en) | 2005-02-18 | 2013-04-17 | 佳能美国生命科学公司 | Devices and methods for monitoring genomic DNA of organisms | 
| USD535403S1              (en) | 2005-02-25 | 2007-01-16 | Fuji Photo Film Co., Ltd. | Component extractor for biochemistry | 
| BRPI0608286A2              (en) | 2005-03-08 | 2009-12-22 | Authentix Inc | system, method and device for identifying and quantifying markers for authenticating a material and method for identifying, authenticating, and quantifying latent markers in a material | 
| CA2967430C              (en) | 2005-03-10 | 2018-05-08 | Gen-Probe Incorporated | Systems and methods to perform assays for detecting or quantifying analytes within samples | 
| US9097723B2              (en) | 2005-04-01 | 2015-08-04 | Caliper Life Sciences, Inc. | Method and apparatus for performing peptide digestion on a microfluidic device | 
| US20060246493A1              (en) | 2005-04-04 | 2006-11-02 | Caliper Life Sciences, Inc. | Method and apparatus for use in temperature controlled processing of microfluidic samples | 
| CA112854S              (en) | 2005-04-10 | 2007-03-27 | Akubio Ltd | Microbalance analyser cartridge | 
| CA2603759A1              (en) | 2005-04-12 | 2006-11-02 | Caliper Life Sciences, Inc. | Compact optical detection system for a microfluidic device | 
| US7300631B2              (en) | 2005-05-02 | 2007-11-27 | Bioscale, Inc. | Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles | 
| USD566291S1              (en) | 2005-05-03 | 2008-04-08 | Handylab, Inc. | Microfluidic cartridge | 
| AU2006244473A1              (en) | 2005-05-06 | 2006-11-16 | Caliper Life Sciences, Inc. | Microtitre plate with a relieved perimeter | 
| US8273294B2              (en) | 2005-07-01 | 2012-09-25 | Honeywell International Inc. | Molded cartridge with 3-D hydrodynamic focusing | 
| US20070020699A1              (en) | 2005-07-19 | 2007-01-25 | Idexx Laboratories, Inc. | Lateral flow assay and device using magnetic particles | 
| USD549827S1              (en) | 2005-09-16 | 2007-08-28 | Horiba, Ltd. | Blood analyzer | 
| CA2621632A1              (en) | 2005-09-30 | 2007-04-12 | Caliper Life Sciences, Inc. | Microfluidic device for purifying a biological component using magnetic beads | 
| US20070199821A1              (en) | 2005-10-05 | 2007-08-30 | Chow Andrea W | Automated two-dimensional gel electrophoresis | 
| US7727371B2              (en) | 2005-10-07 | 2010-06-01 | Caliper Life Sciences, Inc. | Electrode apparatus for use with a microfluidic device | 
| JP2009511059A              (en) | 2005-10-11 | 2009-03-19 | ハンディーラブ  インコーポレイテッド | Polynucleotide sample preparation device | 
| USD537951S1              (en) | 2005-10-21 | 2007-03-06 | Sanyo Electric Co., Ltd. | Gene amplification apparatus | 
| USD556914S1              (en) | 2005-10-21 | 2007-12-04 | Sanyo Electric Co., Ltd. | Gene amplification apparatus | 
| US20070104617A1              (en) | 2005-11-04 | 2007-05-10 | Advanced Biotechnologies Limited | Capped tubes | 
| US20070154895A1              (en) | 2005-12-30 | 2007-07-05 | Caliper Life Sciences, Inc. | Multi-assay microfluidic chips | 
| US8158059B2              (en) | 2005-12-30 | 2012-04-17 | Sotax Corporation | Integrated dissolution processing and sample transfer system | 
| SG134186A1              (en) | 2006-01-12 | 2007-08-29 | Nanyang Polytechnic | Smart nano-integrated system assembly | 
| USD538436S1              (en) | 2006-03-06 | 2007-03-13 | Steris Inc. | Reprocessor for decontaminating medical, dental and veterinary instruments and articles | 
| US8088616B2              (en) | 2006-03-24 | 2012-01-03 | Handylab, Inc. | Heater unit for microfluidic diagnostic system | 
| US7998708B2              (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel | 
| WO2007112114A2              (en) | 2006-03-24 | 2007-10-04 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using same | 
| US8883490B2              (en) | 2006-03-24 | 2014-11-11 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system | 
| USD569526S1              (en) | 2006-03-27 | 2008-05-20 | Handylab, Inc. | Molecular diagnostic instrument | 
| USD559995S1              (en) | 2006-03-27 | 2008-01-15 | Handylab, Inc. | Controller cartridge for a diagnostic instrument | 
| US8021531B2              (en) | 2006-04-14 | 2011-09-20 | Caliper Life Sciences, Inc. | Method for modifying the concentration of reactants in a microfluidic device | 
| USD554069S1              (en) | 2006-05-03 | 2007-10-30 | Data I/O Corporation | Processing apparatus | 
| USD554070S1              (en) | 2006-05-03 | 2007-10-30 | Data I/O Corporation | Processing apparatus | 
| US7629124B2              (en) | 2006-06-30 | 2009-12-08 | Canon U.S. Life Sciences, Inc. | Real-time PCR in micro-channels | 
| WO2008030433A2              (en) | 2006-09-06 | 2008-03-13 | Canon U.S. Life Sciences, Inc. | Chip and cartridge design configuration for performing micro-fluidic assays | 
| US8246919B2              (en) | 2006-09-21 | 2012-08-21 | Abbott Laboratories | Specimen sample rack | 
| US20080095673A1              (en) | 2006-10-20 | 2008-04-24 | Lin Xu | Microplate with fewer peripheral artifacts | 
| WO2008061165A2              (en) | 2006-11-14 | 2008-05-22 | Handylab, Inc. | Microfluidic cartridge and method of making same | 
| KR101422467B1              (en) | 2007-02-08 | 2014-07-24 | 삼성전자주식회사 | A system and a method for detecting fluorescence in microfluidic chip | 
| US7985375B2              (en) | 2007-04-06 | 2011-07-26 | Qiagen Gaithersburg, Inc. | Sample preparation system and method for processing clinical specimens | 
| US9186677B2              (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples | 
| US8287820B2              (en) | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system | 
| US8133671B2              (en) | 2007-07-13 | 2012-03-13 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples | 
| US8105783B2              (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge | 
| US8182763B2              (en) | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders | 
| US20090136385A1              (en) | 2007-07-13 | 2009-05-28 | Handylab, Inc. | Reagent Tube | 
| US9618139B2              (en) | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator | 
| USD632799S1              (en)* | 2008-05-15 | 2011-02-15 | The Automation Partnership | Cell dispenser |