US8668670B2 - Automatic injection devices - Google Patents
Automatic injection devicesDownload PDFInfo
- Publication number
- US8668670B2 US8668670B2US13/443,384US201213443384AUS8668670B2US 8668670 B2US8668670 B2US 8668670B2US 201213443384 AUS201213443384 AUS 201213443384AUS 8668670 B2US8668670 B2US 8668670B2
- Authority
- US
- United States
- Prior art keywords
- syringe
- housing
- plunger
- projecting portion
- injection device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/206—With automatic needle insertion
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31501—Means for blocking or restricting the movement of the rod or piston
- A61M2005/31508—Means for blocking or restricting the movement of the rod or piston provided on the piston-rod
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3287—Accessories for bringing the needle into the body; Automatic needle insertion
Definitions
- an injection devicefor causing a dose of liquid to be ejected from the needle at one end of a syringe located within a housing of the device, the syringe being movable by a plunger, upon release of an actuating bias member at one end of the housing, to move the syringe, from a first position wherein the needle is shrouded by the housing, to a second position wherein the needle projects from the other end of the housing, the plunger being in the form of a rod with a longitudinally centrally located flexible projecting portion which, prior to release of said actuating bias member, is situated beyond the other end of the syringe, such that a primary movement of the plunger, under the bias of the actuating bias member, will cause the projecting portion to bear against the other end of the syringe such that the syringe is moved from said first to said second position, whereupon arresting of further movement of the syringe, results in the flexible portion coll
- the projecting portionwill remain in its projecting position (in order to move the syringe from the first to the second position) until the force increases to such an extent which allows the projecting portion to collapse inwardly so that the plunger can then move within the syringe to cause the liquid to be expressed through the syringe.
- the projecting portioncan comprise one or more flexible elbows projecting beyond the normal circumference of the rod, but compressible into said circumference. This could be in the form of two elbows defined either side of a longitudinal slit in the rod. The elbows could be pre-formed as a pair of arms either side of the longitudinal slit between upper and lower solid portions of the rod.
- the injection devicewill contain a return bias member acting between the syringe housing and the other end of the syringe to hold the syringe retracted within the housing until the actuating bias member is released.
- a return bias memberacting between the syringe housing and the other end of the syringe to hold the syringe retracted within the housing until the actuating bias member is released.
- One or more of the bias members provided within the housingcan be in the form of a coil spring.
- FIG. 1is a sectional view through an injection device of this invention prior to use.
- FIGS. 2 and 3are similar views showing successive stages of operation of the injection member.
- the injection device shown in the drawingscomprises a syringe 1 located within a protective housing 2 .
- the syringecomprises a 3 incorporating a liquid dose held in place by a bung 4 and having a needle 5 through which the dose can be ejected by applying pressure to the bung 4 .
- the 3has an enlarged head 6 .
- a plunger 7is biased forwardly by a coil spring 8 , but is held back in a latched position ( FIG. 1 ) until such time as a trigger shown schematically at 11 is actuated to release the plunger and the spring 8 .
- a coil spring 9Prior to use the syringe 1 is held retracted in the housing 2 by a coil spring 9 .
- the plunger 7is in the form of a rod having a central portion which defines a pair of projecting elbows 10 . These can be pre-formed as part of a moulded plunger 7 .
- the projecting elbow portions 10are flexible so that they can be moved inwardly to cause that portion of the rod to adopt a circumference similar to that of the rest of the rod.
- FIG. 2when the plunger is released and biased by the spring 8 the expanded region formed by the elbows 10 rests against the head 6 of the 3 and the force provided is sufficient to compress the spring 9 until such time as the head 6 abuts the top of the housing 2 , whereupon further movement of the 3 is arrested.
- the continual bias created by the spring 8then causes the elbows 10 to be 20 compressed inwardly as they enter into the interior of the 3 .
- the plungercan then move relatively easily within the 3 so as to act upon the bung 4 and thus cause the contents of the syringe to be ejected through the needle 5 .
- the illustrated configuration of the plunger 7provides several technical advantages. It can be moulded integrally. Also the collapsing movement of the projecting elbows provides an arrangement which can provide a suitable injection force to cause the needle to enter the skin to a suitable depth, but then provide a relatively low drag against the inner wall of the syringe container so that the major portion of the thrust of the spring for the remainder of its stroke is applied to the bung 4 . It will be appreciated that other configurations of collapsing projection could be used in place of the collapsing elbows.
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Description
The instant application is a continuation of U.S. patent application Ser. No. 13/072,289 filed on Mar. 25, 2011 which is a continuation of U.S. patent application Ser. No. 11/630,507 filed Jan. 7, 2008, which is a '371 of PCT Patent Application No. PCT/GB2005/002487, filed Jun. 23, 2005, which claims priority to United Kingdom Patent Application No.: 0414054.7 filed on Jun. 23, 2004. The entire contents of each of the above documents are herein incorporated by reference in their entirety.
There are various forms of automatic injection device which when operated cause the needle of a syringe to be moved forwardly so that it projects from a protective housing prior to actuation of the syringe to express a dose of liquid through the needle. It is important to try to ensure that the syringe is moved bodily forward to expose the needle before the liquid charge is pressurised so that dribbling from the needle does not occur before the actual injection takes place. It is an object of this invention to provide a mechanism which operates in this desired manner.
According to the invention there is provided an injection device for causing a dose of liquid to be ejected from the needle at one end of a syringe located within a housing of the device, the syringe being movable by a plunger, upon release of an actuating bias member at one end of the housing, to move the syringe, from a first position wherein the needle is shrouded by the housing, to a second position wherein the needle projects from the other end of the housing, the plunger being in the form of a rod with a longitudinally centrally located flexible projecting portion which, prior to release of said actuating bias member, is situated beyond the other end of the syringe, such that a primary movement of the plunger, under the bias of the actuating bias member, will cause the projecting portion to bear against the other end of the syringe such that the syringe is moved from said first to said second position, whereupon arresting of further movement of the syringe, results in the flexible portion collapsing inwardly so that it enters the syringe, thus enabling the plunger to move by a secondary movement, within the syringe, into contact with and to act upon a plug to compress the liquid within the syringe and cause expression of the liquid through the syringe needle.
With such an arrangement, the projecting portion will remain in its projecting position (in order to move the syringe from the first to the second position) until the force increases to such an extent which allows the projecting portion to collapse inwardly so that the plunger can then move within the syringe to cause the liquid to be expressed through the syringe.
The projecting portion can comprise one or more flexible elbows projecting beyond the normal circumference of the rod, but compressible into said circumference. This could be in the form of two elbows defined either side of a longitudinal slit in the rod. The elbows could be pre-formed as a pair of arms either side of the longitudinal slit between upper and lower solid portions of the rod.
Preferably the injection device will contain a return bias member acting between the syringe housing and the other end of the syringe to hold the syringe retracted within the housing until the actuating bias member is released. One or more of the bias members provided within the housing can be in the form of a coil spring.
The invention may be performed in various ways and a preferred example thereof will now be described, with reference to the accompanying diagrammatic drawings, in which:
The injection device shown in the drawings comprises a syringe1 located within a protective housing2. The syringe comprises a3 incorporating a liquid dose held in place by a bung4 and having a needle5 through which the dose can be ejected by applying pressure to the bung4. The3 has an enlargedhead 6. A plunger7 is biased forwardly by a coil spring8, but is held back in a latched position (FIG. 1 ) until such time as a trigger shown schematically at11 is actuated to release the plunger and the spring8. Prior to use the syringe1 is held retracted in the housing2 by acoil spring 9.
It will be seen that the plunger7 is in the form of a rod having a central portion which defines a pair of projectingelbows 10. These can be pre-formed as part of a moulded plunger7. The projectingelbow portions 10 are flexible so that they can be moved inwardly to cause that portion of the rod to adopt a circumference similar to that of the rest of the rod. As can be seen inFIG. 2 , when the plunger is released and biased by the spring8 the expanded region formed by theelbows 10 rests against thehead 6 of the3 and the force provided is sufficient to compress thespring 9 until such time as thehead 6 abuts the top of the housing2, whereupon further movement of the3 is arrested. The continual bias created by the spring8 then causes theelbows 10 to be20 compressed inwardly as they enter into the interior of the3. With theelbows 10 in the collapsed state, the plunger can then move relatively easily within the3 so as to act upon the bung4 and thus cause the contents of the syringe to be ejected through the needle5.
The illustrated configuration of the plunger7 provides several technical advantages. It can be moulded integrally. Also the collapsing movement of the projecting elbows provides an arrangement which can provide a suitable injection force to cause the needle to enter the skin to a suitable depth, but then provide a relatively low drag against the inner wall of the syringe container so that the major portion of the thrust of the spring for the remainder of its stroke is applied to the bung4. It will be appreciated that other configurations of collapsing projection could be used in place of the collapsing elbows.
Claims (17)
1. An injection device, comprising:
a housing;
a syringe slideably mounted within the housing for movement between a shrouded retracted position relative to the housing and an extended injecting position relative to the housing;
a movable bung slideably mounted in the syringe and moveable to expel a liquid dose through a needle couplable at a distal end of the syringe;
a plunger having a distal end operable to move the bung and to transmit an expulsion force thereto, the plunger being in the form of a rod including:
an upper solid portion having a circular cross-sectional profile,
a lower solid portion having a distal end operable to move the bung and to transmit an expulsion force thereto, the lower solid portion having a first circular circumference, and
a projecting portion comprising two flexible elbows on either side of a central void extending along a central axis of the plunger between the upper and lower solid portions, wherein the flexible elbows project outwardly from the central void when the projecting portion is in a first projecting position, wherein the flexible elbows are inwardly collapsible toward the central void when the projecting portion is in a second collapsed position; and
an actuating bias spring operable to drive the plunger to move the syringe from the shrouded retracted position relative to the housing to the extended injecting position relative to the housing, and to move the plunger forwardly within the syringe to act upon the bung to transmit the expulsion force thereto in order to expel the liquid dose from the syringe through the needle.
2. The injection device ofclaim 1 , wherein the flexible elbows are formed by bifurcation of opposite ends of the upper and lower solid portions.
3. The injection device ofclaim 1 , wherein the central void is a longitudinal slit in the rod.
4. The injection device ofclaim 1 , wherein the central void has an elongated oval cross-sectional profile extending along the central axis of the plunger, and wherein the central void has a first larger width when the projecting portion is in the first projecting position and a second smaller width when the projecting portion is in the second collapsed position.
5. The injection device ofclaim 1 , further comprising:
a return bias member acting between the housing and a proximal end of the syringe to hold the syringe retracted within the housing until the actuating bias member is released.
6. The injection device ofclaim 5 , wherein one or more of the bias members provided within the housing is in the form of a coil spring.
7. The injection device ofclaim 1 , wherein the housing is held fixed at an injection site and wherein the syringe moves within and relative to the housing during an injection.
8. The injection device ofclaim 1 , wherein the plunger is integrally molded.
9. A syringe assembly, comprising:
a syringe couplable to a needle at a distal end;
a bung slideably mounted in the syringe; and
a plunger comprising:
an upper solid portion having a circular cross-sectional profile,
a lower solid portion having a distal end operable to move the bung and to transmit an expulsion force thereto, the lower solid portion having a first circular circumference, and
a projecting portion comprising two flexible elbows on either side of a central void extending along a central axis of the plunger between the upper and lower solid portions, wherein the flexible elbows project outwardly from the central void when the projecting portion is in a first projecting position, wherein the flexible elbows are inwardly collapsible toward the central void when the projecting portion is in a second collapsed position, and wherein the central void is a longitudinally extending slit.
10. The syringe assembly ofclaim 9 , wherein the syringe is slideably mountable within a housing for movement between a first position relative to the housing in which the needle is shrouded by the housing and a second position relative to the housing in which the needle projects from the housing.
11. The syringe assembly ofclaim 10 , wherein the projecting portion of the plunger is configured to drive the syringe from the first position relative to the housing to the second position relative to the housing such that the needle projects from the housing.
12. The syringe assembly ofclaim 10 , wherein movement of the plunger, upon release of an actuating bias member in an automatic injection device, causes the projecting portion to bear against an enlarged head of the syringe in the automatic injection device to drive the syringe from the first position relative to the housing to the second position relative to the housing.
13. The syringe assembly ofclaim 12 , wherein, when in the second collapsed position, the projecting portion collapses inwardly so that it enters the syringe, wherein the collapse of the projecting portion enables the plunger to move within the syringe to compress a liquid dose within the syringe.
14. The syringe assembly ofclaim 9 , wherein the flexible elbows are formed by bifurcation of opposite ends of the upper and lower solid portions.
15. The syringe assembly ofclaim 9 , wherein the projecting portion of the plunger is in the first projecting position prior to entering the syringe and wherein the projecting portion is in the second collapsed position inside the syringe for applying the expulsion force to the bung.
16. The syringe assembly ofclaim 9 , wherein a housing of an injection device is held fixed at an injection site and wherein the syringe moves within and relative to the housing during an injection.
17. The syringe assembly ofclaim 9 , wherein the plunger is integrally molded.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/443,384US8668670B2 (en) | 2004-06-23 | 2012-04-10 | Automatic injection devices |
| US14/109,363US9017287B2 (en) | 2004-06-23 | 2013-12-17 | Automatic injection devices |
| US14/669,616US9764090B2 (en) | 2004-06-23 | 2015-03-26 | Relating to automatic injection devices |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0414054 | 2004-06-23 | ||
| GB0414054AGB0414054D0 (en) | 2004-06-23 | 2004-06-23 | Improvements relating to automatic injection devices |
| PCT/GB2005/002487WO2006000785A1 (en) | 2004-06-23 | 2005-06-23 | Improvements relating to automatic injection devices |
| US63050708A | 2008-01-07 | 2008-01-07 | |
| US13/072,289US8162887B2 (en) | 2004-06-23 | 2011-03-25 | Automatic injection devices |
| US13/443,384US8668670B2 (en) | 2004-06-23 | 2012-04-10 | Automatic injection devices |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US13/072,289ContinuationUS8162887B2 (en) | 2004-06-23 | 2011-03-25 | Automatic injection devices |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US14/109,363ContinuationUS9017287B2 (en) | 2004-06-23 | 2013-12-17 | Automatic injection devices |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| US20120197209A1 US20120197209A1 (en) | 2012-08-02 |
| US8668670B2true US8668670B2 (en) | 2014-03-11 |
Family
ID=32800025
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US11/630,507Active2026-03-22US7938802B2 (en) | 2004-06-23 | 2005-06-23 | Automatic injection devices |
| US13/072,289Expired - LifetimeUS8162887B2 (en) | 2004-06-23 | 2011-03-25 | Automatic injection devices |
| US13/443,384Expired - LifetimeUS8668670B2 (en) | 2004-06-23 | 2012-04-10 | Automatic injection devices |
| US14/109,363Expired - LifetimeUS9017287B2 (en) | 2004-06-23 | 2013-12-17 | Automatic injection devices |
| US14/669,616Expired - LifetimeUS9764090B2 (en) | 2004-06-23 | 2015-03-26 | Relating to automatic injection devices |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US11/630,507Active2026-03-22US7938802B2 (en) | 2004-06-23 | 2005-06-23 | Automatic injection devices |
| US13/072,289Expired - LifetimeUS8162887B2 (en) | 2004-06-23 | 2011-03-25 | Automatic injection devices |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US14/109,363Expired - LifetimeUS9017287B2 (en) | 2004-06-23 | 2013-12-17 | Automatic injection devices |
| US14/669,616Expired - LifetimeUS9764090B2 (en) | 2004-06-23 | 2015-03-26 | Relating to automatic injection devices |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US7938802B2 (en) |
| EP (3) | EP1758627B1 (en) |
| JP (5) | JP2008503296A (en) |
| KR (2) | KR101202123B1 (en) |
| CN (4) | CN103055381A (en) |
| AU (1) | AU2005256832B2 (en) |
| BR (1) | BRPI0512554B1 (en) |
| CA (2) | CA2571571C (en) |
| ES (1) | ES2672336T3 (en) |
| GB (1) | GB0414054D0 (en) |
| IN (1) | IN2014DN04769A (en) |
| MX (2) | MX345765B (en) |
| NZ (3) | NZ587235A (en) |
| RU (1) | RU2387460C2 (en) |
| WO (1) | WO2006000785A1 (en) |
| ZA (1) | ZA200700289B (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140276444A1 (en)* | 2004-06-23 | 2014-09-18 | Abbvie Biotechnology Ltd | Automatic injection devices |
| US9561328B2 (en) | 2009-04-29 | 2017-02-07 | Abbvie Biotechnology Ltd | Automatic injection device |
| US10869966B2 (en) | 2015-02-20 | 2020-12-22 | Regeneron Pharmaceuticals, Inc. | Syringe systems, piston seal systems, stopper systems, and methods of use and assembly |
| US12226614B2 (en) | 2020-12-31 | 2025-02-18 | Regeneron Pharmaceuticals, Inc. | Auto-injector and related methods of use |
| US12247071B2 (en) | 2016-12-21 | 2025-03-11 | Amgen Inc. | Anti-TNF alpha antibody formulations |
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| US20090204076A1 (en)* | 2003-02-03 | 2009-08-13 | Barry Peter Liversidge | Medical Injector |
| US7947017B2 (en) | 2004-11-22 | 2011-05-24 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
| US7648483B2 (en) | 2004-11-22 | 2010-01-19 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
| US11590286B2 (en) | 2004-11-22 | 2023-02-28 | Kaleo, Inc. | Devices, systems and methods for medicament delivery |
| WO2006057636A1 (en) | 2004-11-22 | 2006-06-01 | Intelliject, Llc | Devices, systems, and methods for medicament delivery |
| US10737028B2 (en) | 2004-11-22 | 2020-08-11 | Kaleo, Inc. | Devices, systems and methods for medicament delivery |
| HUE042286T2 (en) | 2005-01-24 | 2019-06-28 | Antares Pharma Inc | Needle-filled pre-filled syringe |
| US8206360B2 (en) | 2005-02-01 | 2012-06-26 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
| US8361026B2 (en) | 2005-02-01 | 2013-01-29 | Intelliject, Inc. | Apparatus and methods for self-administration of vaccines and other medicaments |
| US8231573B2 (en) | 2005-02-01 | 2012-07-31 | Intelliject, Inc. | Medicament delivery device having an electronic circuit system |
| US9022980B2 (en) | 2005-02-01 | 2015-05-05 | Kaleo, Inc. | Medical injector simulation device |
| AU2006210865B2 (en) | 2005-02-01 | 2008-12-04 | Kaleo, Inc. | Devices, systems, and methods for medicament delivery |
| EP3165247B1 (en) | 2006-02-09 | 2020-10-28 | DEKA Products Limited Partnership | Pumping fluid delivery systems and methods using force application assembley |
| US20070191780A1 (en)* | 2006-02-16 | 2007-08-16 | Pankaj Modi | Drug delivery device |
| WO2007131025A1 (en) | 2006-05-03 | 2007-11-15 | Antares Pharma, Inc. | Injector with adjustable dosing |
| WO2007131013A1 (en) | 2006-05-03 | 2007-11-15 | Antares Pharma, Inc. | Two-stage reconstituting injector |
| RU2438721C2 (en)* | 2006-06-30 | 2012-01-10 | Эбботт Байотекнолоджи Лтд. | Automatic injection device |
| KR101396797B1 (en)* | 2006-06-30 | 2014-05-26 | 애브비 바이오테크놀로지 리미티드 | Automatic injection device |
| USD629509S1 (en) | 2006-09-06 | 2010-12-21 | Abbott Biotechnology Ltd. | Automatic injection device |
| EP2125075A2 (en) | 2007-01-22 | 2009-12-02 | Intelliject, Inc. | Medical injector with compliance tracking and monitoring |
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- 2013-12-17USUS14/109,363patent/US9017287B2/ennot_activeExpired - Lifetime
- 2014
- 2014-04-03JPJP2014077283Apatent/JP5883057B2/ennot_activeExpired - Fee Related
- 2015
- 2015-03-26USUS14/669,616patent/US9764090B2/ennot_activeExpired - Lifetime
- 2016
- 2016-07-11JPJP2016136734Apatent/JP2016179256A/enactivePending
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