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US5933389A - Ultrasonic imaging system and method - Google Patents

Ultrasonic imaging system and method
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US5933389A
US5933389AUS08/926,270US92627097AUS5933389AUS 5933389 AUS5933389 AUS 5933389AUS 92627097 AUS92627097 AUS 92627097AUS 5933389 AUS5933389 AUS 5933389A
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ultrasonic
harmonic
transmit
transducer array
transducer
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US08/926,270
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John A. Hossack
Jian-Hua Mo
Christopher R. Cole
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Siemens Medical Solutions USA Inc
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Acuson Corp
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Abstract

A transmit beamformer includes multiple transducers, each responsive to a respective transmit waveform to produce a respective transducer waveform. A transmit waveform generator generates the transmit waveforms, and the transmit waveforms each include multiple frequency components. Progressively higher frequency components of the transmit waveforms are timed to cause corresponding progressively higher frequency components of the transducer waveforms to focus along a line at progressively shorter ranges. In this way, a frequency dependent line focus is achieved.

Description

This application is a division of application Ser. No. 08/771,345, filed Dec. 16, 1996, now U.S. Pat. No. 5,696,737 which in turn was a division of application Ser. No. 08/397,833, filed Mar. 2, 1995, now U.S. Pat. No. 5,608,690.
BACKGROUND OF THE INVENTION
This invention relates to beamformers, and in particular to a transmit beamformer that provides improved focusing.
Ultrasonic imaging is widely used in many settings, including medical applications. A typical ultrasonic imaging system includes an array of transducers, a transmit beamformer, and a receive beamformer. The transmit beamformer supplies transmit waveforms (which may be voltage waveforms) to the transducers, which in turn produce respective ultrasonic transducer waveforms (which are pressure waveforms). In a phased array system, the transmit waveforms are delayed in time to cause the ultrasonic waveforms to interfere coherently in a selected region in front of the transducers.
Structures in front of the transducers scatter ultrasonic energy back to the transducers, which generate associated receive waveforms (which may be voltage waveforms). These receive waveforms are delayed for selected times that are specific for each transducer such that ultrasonic energy scattered from a selected region adds coherently, while ultrasonic energy from other regions does not.
It is well recognized that the absorption characteristics of the body being imaged can have a significant impact on the operation of an ultrasonic imaging system. For example, the ultrasonic absorption coefficient of living tissue increases with frequency, and lower frequencies are therefore preferred for imaging at greater depths. Higher frequencies provide improved resolution in the range dimension than lower frequencies, and higher frequencies are preferred for imaging at shallower depths.
Pittaro U.S. Pat. No. 5,113,706 discloses an ultrasonic imaging system that divides the body being imaged into several zones, and uses a separate burst of ultrasonic energy at a separate frequency and power level for each zone. In this system, transmit focus and power are stepped over the entire multi-zone focal range of interest, with successive bursts that increase in focal depth, decrease in frequency, and increase in power.
One disadvantage of the system disclosed in the Pittaro patent is that multiple bursts are fired for each transducer steering position. Such multiple bursts can increase the time needed to complete an entire image. The Pittaro patent makes a brief suggestion at column 13, lines 35-39 that frequency multiplexing can be used so that the multiple wavefronts for a given steering position can be concurrent rather than successive, but no further details are given.
SUMMARY OF THE INVENTION
This invention is directed to an improved transmit beamformer that reduces or eliminates the need for multiple bursts at a given transducer steering position, and thereby increases the rate at which an image can be generated while maintaining multiple focal points.
According to this invention, a transmit beamformer generates transmit waveforms for an array of transducers, which respond by producing associated transducer waveforms. Each of at least some of the transmit waveforms comprises at least first and second frequency components which are included in a single burst of energy. The first frequency components are timed to cause corresponding first frequency components of the transducer waveforms to focus at a first, greater depth, and the second frequency components are timed to cause corresponding second frequency components of the transducer waveforms to focus at a second, shallower depth.
In the preferred embodiments discussed below, each transmit waveform includes more than two frequency components, and progressively higher frequency components of the transmit waveforms are timed to cause corresponding progressively lower frequency components of the transducer waveforms to focus at progressively greater depths.
As used herein, the term "frequency component" is meant to be interpreted broadly so as to encompass frequency components having any suitable bandwidth. Where frequency components have a finite bandwidth, they may be spaced such that adjacent components fill the bandwidth, and are therefore substantially continuous.
These embodiments allow high image-frame rates, since a single set of transmit waveforms is used to inject energy into short, intermediate and long range parts of the body being imaged. Furthermore, since the focused energy is distributed along a line, more energy may be injected into the body before power limits such as those imposed by governmental regulatory agencies are exceeded.
BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 is a block diagram of an ultrasonic imaging system that incorporates a presently preferred embodiment of this invention.
FIG. 2 is a graph of a time domain function h(t).
FIGS. 3 and 4 are graphs of the amplitude and phase, respectively, of a frequency domain function H(f), the Fourier transform of h(t).
FIGS. 5 and 6 are graphs of the amplitude and phase of a time shifted frequency domain function H'i (f).
FIG. 7 is a graph showing the time development of selected transmit waveforms.
FIG. 8 is a graph corresponding to the waveforms of FIG. 7 filtered through a 3 MHz bandpass filter.
FIG. 9 is a graph of the waveforms of FIG. 7 filtered through a 7 MHz bandpass filter.
FIGS. 10 and 11 are graphs showing the high and low frequency wavefronts in two alternate sets of transmit waveforms.
FIG. 12 is a block diagram showing a first preferred embodiment of thetransmit beamformer 12.
FIG. 13 is a block diagram showing a second preferred embodiment of thetransmit beamformer 12.
FIG. 14 is a block diagram showing a third preferred embodiment of thetransmit beamformer 12.
FIG. 15 is a block diagram showing a fourth preferred embodiment of thetransmit beamformer 12.
FIG. 16 is a graph of unfiltered and filtered spectra (3, 5, 7 MHz).
FIG. 17 is a graph showing focal distance versus transducer number for 3, 7 and 10 MHz components.
FIG. 18 is a graph of spectra of transmit waveforms for the center through end transducers within the frequency range of 0-10 MHz.
FIG. 19 is a contour plot of the spectra of FIG. 18.
FIG. 20 is a graph showing transmit waveforms fortransducers 1, 32 and 63 with no incremental delay.
FIG. 21 is a graph of transmit waveforms fortransducers 1, 32 and 63 with incremental delay.
FIG. 22 is a graph showing variation of focal range with frequency, using a far focus of 140 mm, a near focus of 40 mm and a near focal limit of 28 mm.
FIG. 23 is a graph showing the track of an ultrasound line with a radius of 500 mm.
FIG. 24 is a graph showing a modified waveform.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
The following discussion first discusses general system considerations, and then turns to a detailed discussion of individual components of the preferred system.
System Overview
FIG. 1 is a block diagram of an ultrasonic imaging system which incorporates a preferred embodiment of this invention. Atransmit beamformer 12 applies analog transmit voltage waveforms via amultichannel switch 14 to an array oftransducers 16. Thetransducers 16 each receive a respective transmit waveform and generate a respective ultrasonic transducer pressure waveform. The ultrasonic transducer waveforms are timed and shaped as described below to add coherently along a selected spatial axis, with higher frequency components of the ultrasonic waveforms focused at shorter ranges (depths), intermediate frequency components focused at intermediate ranges (depths), and lower frequency components focused at longer ranges (depths). By way of example, frequency components centered at 7, 5 and 3 MHz can be focused at ranges of 40, 90 and 140 mm, respectively.
This frequency-dependent focus concentrates higher frequency ultrasonic waves at shorter ranges where they are most useful. Body attenuation increases with higher frequencies, which makes higher frequencies less useful at long ranges.
Echoes from body structures are detected by thetransducers 16, which generate respective receive voltage waveforms. These receive waveforms are applied via themultichannel switch 14 to a receivebeamformer 18, which applies suitable delays and filters to the receive waveforms to create a coherent sum for selected points along the spatial axis. Echoes are received sooner from closer ranges, which as explained above are associated with higher frequency components of the transmitted ultrasonic waveforms.
In one mode of operation, the receive beamformer selects delays to focus at progressively longer ranges along the line, thereby sampling multiple points along the line. In order to take advantage of the time-varying frequency distribution of ultrasonic energy along the line of focus, the receivebeamformer 18 preferably includes a time-varying bandpass filter that attenuates frequency components of the receive waveforms other than those characteristic of the focal range of interest. In the above example, this bandpass filter is centered at 7, 5, and 3 MHz attimes 2·40/c, 2·80/c, and 2·140/c respectively, where c is the speed of sound in the body. The center frequency of the bandpass filter varies progressively from 7 MHz at 2·40/c to 3 MHz at 2·140/c.
Transmit Waveform Determination
Transmit waveforms having the frequency-dependent focus characteristics described above can be determined as follows.
The first step is to select a starting waveform in the time domain. This starting waveform can, for example, be a pulse h(t) having a Gaussian spectrum, as shown in FIG. 2. This pulse h(t) has a fractional bandwidth of 80% at the -6 dB points, i.e., 2·(fHI -fLO)/(fHI +fLO)=80%, where fHI is the upper frequency at -6 dB with respect to the maximum level and fLO is the lower frequency at -6 dB with respect to the maximum level. In this specification the notation "80% -6 dB bandwidth" will be used for such a pulse. A Fourier transform is then used to convert the waveform h(t) to the frequency domain to form H(f), having amplitude and phase as shown in FIGS. 3 and 4. The starting waveform can be modified to take into account the amplitude/phase response of the transducer, as well as amplitude/phase errors in the electronics of the beamformer. For example, if the transducer is assumed to have an 80% -6 dB bandwidth, a starting waveform having a 150% -6 dB bandwidth results in a net 67% -6 dB bandwidth. Corrections for imperfections in electronics such as amplifiers and smoothing filters, and for amplitude and/or phase errors associated with potential divider effects between amplifier output impedance and transducer impedance permit less stringent specifications and therefore lower cost parts to be used.
Each frequency of interest is then assigned to a particular focal range by means of a smoothly varying function g such that Z=g(f), where Z is the focal range for the frequency f. In this example g is selected such that 3, 5 and 7 MHz are assigned to focal ranges of 140, 90 and 40 mm, respectively.
The next step is to determine the actual transmit waveform for each of the transducers and for the desired line of focus. By way of example, assume Z=40 mm, f=7 MHz, 128 transducers are arranged with a pitch of 0.15 mm, c=1.5 mm/μs, and the line of focus is normal to the transducer array and passes through the center of the transducer array.
In order to calculate the delays for the 7 MHz frequency components of each of the 128 transmit waveforms, the distance and time from transducer i to the desired focal point are calculated according to the following formulae: ##EQU1## where Xi equals the spacing of the ith transducer from the center of the transducer array.
For example, for Z=40 mm, and one of the two transducers closest to the center, ##EQU2## For Z=40 mm and the end transducer, X=(63.5×0.15 mm)=9.52 mm and ##EQU3## Thus, the 7 MHz component of the end transducer must be advanced by 27.4-26.7=0.7 μs with respect to the 7 MHz component of the central transducers. In this context, `advanced` equals `negative delayed`. This delay can be accomplished in the frequency domain by multiplying H(f) by e-j2πft, where t=-0.7 μs and f=7 MHz for this particular frequency component. The process is repeated for all transducers and all frequency components (and associated focal ranges) of interest.
The foregoing example relates to a center scan line that is straight and normal to the transducer array. A similar approach can be used for off-center and curved scan lines, as long as Xi and Z are selected properly. That is, the range calculation should use Xi and Z as measured from the intended focal point to the ith transducer. By positioning the intended focal point properly, delays for angled scan lines and curved scan lines can readily be determined.
In many cases it will be preferable to avoid negative delays (advances) that imply transmit waveforms having non-zero values before t=0. This can be done by calculating the greatest expected end-to-center delay difference for the entire transducer array. This greatest delay difference generally occurs at the nearest focal distance, and is assigned as a constant denoted Delay-- Max. The required time advances (negative delays) discussed above may now be added to Delay-- Max to determine the time value to be used in the frequency domain delay operations, thereby avoiding all negative delays. Of course, any constant value greater than Delay-- Max is also suitable.
This process is repeated for all frequencies for the ith transducer to produce H'i (f), having the amplitude and phase shown in FIGS. 5 and 6, respectively. The frequency domain function H'i (f) is then converted by use of an inverse Fourier transform to form the time domain function h'i (t), which is the transmit waveform for the ith transducer.
FIG. 7 shows the transmit waveforms for five of the transducers h0, h31, h63, h95, h127, where h0 and h127 are the transmit waveforms for the end transducers, and H63 is the transmit waveform for one of the two central transducers. Note that in each case all of the frequency components in any one transmit waveform are combined in a single burst of energy or a single frequency modulated pulse signal, rather a sequence of multiple unmodulated pulses. Each transmit waveform is a continuously, constantly varying signal, rather than multiple pulses separated by a non-varying period lasting more than two times the period of the lowest frequency within the -6 dB bandwidth of the transmit waveform. FIG. 8 shows the transmit waveforms of FIG. 7 filtered with a bandpass filter centered at 3 MHz. The dotted line in FIG. 8 shows the curved wavefront of the 3 MHz components, that causes these lower frequency components to focus at the long range of 140 mm. FIG. 9 shows the transmit waveforms of FIG. 7 filtered with a bandpass filter centered at 7 MHz. The dotted line in FIG. 9 shows the more deeply curved wavefront of 7 MHz components, that causes these higher frequency components to focus at the short range of 40 mm.
Note that the transmit waveform for each transducer includes a wide range of frequency components, and the delays for individual frequency components are selected such that the separate frequency components of each transmit waveform are focused at respective focal ranges. The transducer waveforms produced by the transducer array as a whole generate a continuous line focus rather than a point focus, and differing frequency components are focused at differing ranges or depths along the line. At least for some of the transmit waveforms, the various frequency components are contained in a single burst of energy.
The foregoing discussion illustrates only one approach to determining the transmit waveforms. Many modifications and alternatives are possible, including the following.
The transmit waveforms may be shaped to reduce the effect of ringing in the waveforms of the transducers at the end of the array by using conventional aperture apodization techniques to emphasize the response of the center elements at the expense of the end elements. Low-pass filtering may be used on the transmit waveforms for the end elements to suppress high frequency ringing, which is largely due to rapidly changing phase at higher frequencies. Additionally, higher frequency components may be focused at longer ranges for the end transducers than for the center transducers. It is often not necessary to focus any part of the pressure wave from end elements at extremely close ranges, and by focusing all of the pressure wave from end elements at longer ranges, high phase changes and associated ringdown can be reduced.
Additionally, the delay profile can be continued down to 0 Hz and up to beyond 10 MHz. Beyond the upper band edge of the transducer, it may be disadvantageous to continue to reduce the focal distance at a constant rate. A minimum focal range can be defined, which higher frequencies approach asymptotically. As mentioned above, the near focal limit may not be the same for the end transducers as for the center transducers.
The transmit waveforms may additionally be designed to compensate for beamforming distortions. For example, since different frequency components are attenuated by different amounts in the body, low frequency components may be enhanced in amplitude to increase the energy focused at long range targets. To the extent that the effective velocity of ultrasonic waves in the body varies with frequency, such variations can be taken into account in calculating the delays used in determining the transmit waveforms.
It is known in the art that lower frequencies can be used for off-axis ultrasound scan lines to reduce the adverse effect of grating lobes due to undersampling at high frequencies for wide element spacing. This approach can readily be used in determining the transmit waveforms for such scan lines.
The previous discussion has related to the objective of producing temporally compact wave-forms along the scan line. In certain applications it is desirable to produce temporally long waveforms. Coded waveforms of the type described by M. O'Donnell in IEEE Trans. UFFC Vol. 39, No. 3, pp. 341-351 may also be used with this invention. These waveforms, which are essentially `chirp` waveforms, have the advantage of higher signal to noise since they increase pulse energy without increasing peak power and hence take advantage of the fact that regulatory limits on peak acoustic power are more burdensome than the limits on peak acoustic energy in this application. (Signal to noise is related more to signal energy than signal power). Since the different frequency components are focused to different points, the nature of the focused waveform will vary with range. Nevertheless, by filtering to a reduced bandwidth (e.g., 30% -6 dB fractional bandwidth), the resultant waveform will contain well focused components. Another feature of `chirp`-like waveforms is that if the low frequencies occur earlier than the high frequency components, the total temporal spread in the waveforms applied to the end elements may be reduced. FIG. 10 illustrates the high and low frequency components in such a case. Note that the total delay from the start to finish of the transmit waveforms is reduced in FIG. 10 as compared to FIG. 11, which shows the alternate relationship.
In the present invention, a preferred `chirp` waveform may be developed as follows for substitution in place of the starting waveform illustrated in FIG. 2. The design of this `chirp` waveform scales the incremental delay between successive frequency components with the period of the particular frequency component. These delays are applied to the frequency components making up the original pulse, which may, like the pulse illustrated in FIG. 2, have a Gaussian spectral envelope and linear phase for all frequency components. For simplicity, the current discussion considers a discretely sampled spectrum comprising frequency samples at f(j), where f(j) is the frequency of the jth sample. Generally, waveforms in this invention are continuous in both the time and frequency domains. This condition may be obtained by letting discrete sample intervals tend to infinitesimally small values. ##EQU4## where ##EQU5## n=number of elements in the transducer array, Z=near focal distance for high chosen frequency component (40 mm in this example),
N=number of frequency samples between low frequency component fLO (3 MHz in this example) and high frequency component fHI (7 MHz in this example),
fc =center frequency=5 MHz in this example,
fj =frequency of jth sample.
Delays are calculated over the range 0.3·fLO to 2·fHI, where fLO =3 MHz and fHI =7 MHz in this example. Delays for samples where f(j) is less than 0.3·fLO are set equal to zero. Delays for samples where f(j) is greater than 2·fHI are set equal to the delay for the sample corresponding to f(j)=2·fHI. A chirp waveform has the advantage that energy is spread out in time and hence peak power is lowered, reducing the risk of exceeding government regulated power levels.
The waveforms corresponding to a number of separate ultrasound lines can be calculated and then summed prior to application to the transducers such that ultrasonic energy is focused along several different scan lines. The transmit scan lines may be straight or curved, as desired. If the transmit scan lines are curved, the azimuthal position of the focus varies with range and frequency. The receive beamformer would preferably accommodate this change, and the scan converter would write to X-Y locations using curved rather than straight line acoustic data. As an example, in the scan converter described by S. C. Leavitt et al. `A Scan Conversion Algorithm for Displaying Ultrasound Images` (Hewlett-Packard Journal, October 1983, pp. 30-34), the X-Y Raster State Machine (page 33) could be programmed with a sequence of X-Y pixel addresses following a curved rather than straight trajectory. Also, each transmit scan line may be spread out in width. For example, in some applications it may be preferable to spread or defocus the beam to a width such as 4° to allow multiple receive scan lines for a single transmit scan line.
Transmit Beamformer
Once the desired transmit waveforms have been determined as discussed above, the transmitbeamformer 12 can be implemented as shown in FIG. 12 to generate the previously determined transmit waveforms.
The transmitbeamformer 12 includes N channels, one for each of the transducers 16 (FIG. 1). Each channel includes adelay memory 20, awaveform memory 22, and a delay counter 24 (FIG. 12). Thedelay memory 20 includes 256words 26, one for each possible steering angle or ultrasound scan line. Thewaveform memory 22 includes 256sections 28, one for each possible steering angle. Eachword 26 is set equal to a negative number equal to the number of clock cycles that elapse between a start of line signal and the first non-zero value of the associated waveform. For simplicity, it is assumed that zero is defined as the most significant bit equal to 1 and all other bits equal to 0. Hence, the most significant bit becomes an enable signal for the memory. Eachsection 28 stores a respective waveform, for example as 64 or 128 successive eight bit words. When asection 28 is read with a 40 MHz clock, the resulting sequence of digital values defines a waveform approximately 1.6 to 3.2 μs in duration. Thedelay memory 20 is not required, but it reduces memory requirements for thewaveform memory 22. This is because thedelay memory 20 eliminates the need to store a large number of leading zeros when the ultrasound line is steered at a large angle.
In use, each channel responds to a scan line selection signal online 30 by loading theword 26 for the selected scan line into thedelay counter 24, and by enabling the selectedsection 28 of thewaveform memory 22. Typically, eachword 26 stores a negative binary integer equal to the desired delay before the first non-zero value of the respective waveform.
Thedelay counter 24 responds to a start of scan line signal online 32 by incrementing the stored value with each cycle of a 40 MHz clock. When thecounter 24 increments to zero, it enables thewaveform memory 22. Subsequently generated values of the counter 24 (incrementing now from zero upwards) become address values for thememory 22. As each word of thesection 28 for the selected scan line is addressed, the corresponding eight bit word is read and applied to a digital-to-analog converter 34. The analog output signal of theconverter 34 is passed through a low-pass filter such as aBessel filter 36 to reduce sampling effects and then to anamplifier 38. The output of theamplifier 38 is the transmit waveform discussed above that is applied to therespective transducer 16 via the multichannel switch 14 (FIG. 1).
In general, there is considerable similarity between waveforms applied toadjacent transducers 16 and between waveforms of adjacent lines. A number of approximations can be used which take advantage of the redundancy in the information stored in thewaveform memory 22 to reduce memory requirements.
Another approach is shown in FIG. 13, which includes many of the same components as those discussed above in conjunction with FIG. 12. The central difference between the systems of FIGS. 12 and 13 is that each transducer channel of the system of FIG. 13 uses only a singlewaveform memory section 28 that stores only a single waveform made up of 64 or 128 eight bit words. The waveform stored in thewaveform memory section 28 may be the waveform calculated for the center scan line. The system of FIG. 13 functions as described above in conjunction with FIG. 12, except that the scan line number select signal does not select one of multiple waveform memory sections. All of the waveforms for all of the ultrasound scan lines are identical in shape. They differ from one another only in that linear delays are applied to successive scan lines to effect scan line steering.
When the approach of FIG. 13 is used it should be understood that as each scan line is steered farther from the central scan line perpendicular to the transducer array, an error in the focusing component causes the focal points to approach the transducers by a factor of (cos θ)2, where θ is the steering angle measured with respect to the perpendicular. This focusing error results from the fact that the effective pitch between adjacent transducers is modified by cos θ for non-perpendicular steering angles, and the resulting delay is modified by (cos θ)2.
As an improvement to compensate partially for this effect, one can calculate the delays required to focus at the desired range (for example 140 mm). One can then calculate the delays required to focus at 70 mm (i.e. the range to which the beam is actually focused if it was originally focused at 140 mm but has been steered to 45°). The difference in the delays for 140 mm and 70 mm can be applied to the waveforms discussed above to compensate for this focusing error. This correction applies exactly only to one frequency component, and other frequency components (and associated other ranges) will not be exactly corrected.
FIG. 14 shows another system that uses an interpolator to reduce memory requirements as compared to the system of FIG. 12. In the system of FIG. 14 thedelay memory 20, thedelay counter 24 and thecomponents 34, 36 and 38 are as described above. In this case thewaveform memory 22 includessections 28 that store only every fourth (or other power of two) waveform for the respective transducer. The actual waveform used by intermediate lines is interpolated digitally using theshifters 40, 42, thesummer 44 and theactual waveform memory 46.
A central controller provides first and second waveform select signals which select the two waveforms to be used for the interpolation. This controller also generates shifter control signals. The first waveform identified by the first waveform select signal is applied to thefirst shifter 40, and the second waveform identified by the second waveform select signal is applied to the second shifter 42. Each of theshifters 40, 42 supplies outputs equal to selected ones of the following: the corresponding waveform divided by 1, the corresponding waveform divided by two, and the corresponding waveform divided by four. The outputs of theshifters 40, 42 can be obtained at high speed by simple shifting operations. Thesummer 44 sums the various signals generated by theshifters 40, 42 to generate the actual waveform, which is stored in theactual waveform memory 46.
Thisactual waveform memory 46 stores 128 eight bit signals. Thedelay counter 24 is loaded with the appropriate delay from thedelay memory 20, and then clocked beginning at the start-of-scan-line signal. When the value in thedelay counter 24 goes positive, it addresses consecutive words in theactual waveform memory 46 and applies them to the digital-to-analog converter 34.
Table 1 provides further information regarding the operation of thewaveform memory 22 and theshifters 40, 42.
              TABLE 1______________________________________First         SecondWaveform      Waveform  Shifter 40 Shifter 42Line No.        Select Signal                  Select Signal                            ÷1                                ÷2                                    ÷4                                         ÷1                                             ÷2                                                 ÷4______________________________________0       0         4         1   0   0    0   0   01       0         4         0   1   1    0   0   12       0         4         0   1   0    0   1   03       0         4         0   0   1    0   1   14       4         8         1   0   0    0   0   05       4         8         0   1   1    0   0   1______________________________________
As shown in Table 1, for scan lines 0-3 thescan line 0 and 4 waveforms are applied to theshifters 40, 42, respectively.Scan line 0 is equal to the waveform stored inscan line 0 of thewaveform memory 28, because only the +1 output of theshifter 40 is enabled. Similarly,scan line 1 is equal to the sum of 1/2 plus 1/4 of the waveform forscan line 0 plus 1/4 of the waveform forscan line 4. The waveform forscan line 2 is equal to 1/2 the waveform forscan line 0 plus 1/2 of the waveform forscan line 4.
Since the delay between adjacent scan lines is at least 50 microseconds for a target at a distance of 40 mm, there is sufficient time to accomplish simple digital interpolations using shifts, which can be hardwired, and selected adds of shifted components from adjacent lines.
Interpolated waveforms can also be determined by generating two digital waveforms, converting them to their analog counterparts, and then performing the desired interpolation as a weighted analog sum using controlled gain amplifiers and a summer. This approach is an analog version of the system of FIG. 14. It is possible to use interpolation techniques similar to those of FIG. 14 to interpolate between successive transducers. Also, it is possible to store only a limited set of waveforms (either for a limited set of lines and/or a limited set of transducers). One would use the closest stored waveform for transducers and/or lines which are not explicitly stored. The extent of hardware simplicity afforded by this technique is balanced with a slight loss of performance.
FIG. 15 relates to another system which takes advantage of the fact that there is considerable redundancy between the waveforms applied to adjacent scan lines for any given transducer. As shown in FIG. 15, thewaveform memory 48 stores the complete waveform for a given transducer, such as the waveform forscan line 0. A value ΔWFM is stored for each subsequent scan line. Thesummer 50 is initially loaded with the waveform forscan line 0, and ΔWFM1, ΔWFM2 . . . ΔWFMN are then successively added. In each case ΔWFMn is the increment between the waveform for scan line (n-1) and the waveform for scan line n. The contents of thesummer 50 represent the actual waveform for the transducer of interest and the corresponding scan line. This actual waveform is clocked by thedelay counter 24 into a digital-to-analog converter 34. For example, thesummer 50 can add the waveform forscan line 1 to the value of ΔWFM forscan line 2 to generate the actual waveform for the second scan line and the respective transducer. The approach of FIG. 15 is especially well suited for use in systems in which scan lines are fired in consecutive order. The basic approach illustrated in FIG. 15 can be adapted for successive transducers instead of or in addition to successive scan lines.
Arbitrary waveforms of the type described above can be generated with conventional function generators, such as the Model DS345 synthesized function generator of Stanford Research Systems. An array of such devices is a practical approach to implementing the transmitbeamformer 12 in the shortest amount of time, particularly when a smaller number of transducers such as sixteen is used.
Since the capacity of the GPIB which connects a computer to several DS345's is limited, it may be necessary to use more than one computer and build the beamformer with subarrays with separate computers and GPIB's. This system is still practical since once all the DS345's in the different subarrays have been programmed they can be triggered from a single external synchronizing source.
There are other means for generating approximations to the waveforms discussed above. One approach is to produce a square wave burst with a period between successive transitions that determines the fundamental frequency. A low-pass filter can be applied to remove the harmonics and to smooth the waveform to make it more like one of the waveforms discussed above. This technique would also achieve the effect of focusing various frequency components at various respective ranges.
It is anticipated that the programmable waveform transmit beamformer described in Cole et al. U.S. patent application Ser. No. 08/286,652, filed Aug. 5, 1994, and assigned to the assignee of the present invention can be adapted for use with this invention.
Transducers
A wide variety oftransducers 16 can be used, and this invention is not limited to the linear transducer array discussed above. The techniques discussed above of delaying separate frequency components (so as to achieve a multiple focal ranges) may be applied to two dimensional arrays having M azimuth elements and N elevation elements, or to a 1.5 dimension array which will typically have a small number of elements in the elevation direction, such as 3, 5 or 7.
A plano-concave transducer array can be used in which different frequency components are focused at different ranges in elevation. See for example the discussion in the continuation in part of Hanafy U.S. patent application Ser. Nos. 08/117,869 and 08/117,868, filed Sep. 7, 1993.
The Receive Beamformer
The receivebeamformer 18 preferably includes a dynamic receive focusing system that allows the focus of the receive beamformer to be changed at a high rate in order to follow as accurately as possible the range along the ultrasonic scan line corresponding to the currently arriving signals.
Preferably, the receivebeamformer 18 includes a time-varying adjustable bandpass filter which is adjusted in real time to emphasize the frequency of the currently arriving signals. Green U.S. Pat. No. 4,016,750 describes a simple analog implementation for such a time-varying filter. A high-pass filter can be substituted for a bandpass filter. The body acts as a low-pass filter, and for this reason a high-pass filter may be sufficient to achieve the desired effect.
When a time-varying bandpass filter is used, it can slide from above 7 MHz to below 3 MHz if desired. The slide rate function need not be uniform with respect to time. The optimum bandwidth and filter characteristics of the sliding filter can best be determined from experience and by using design tools. A narrow bandwidth will give higher focusing accuracy but relatively poor axial (range) resolution due to ring down. The frequency downshift related to natural body attenuation should be taken into account in the design of such a filter.
Heterodyne time-varying filters may also be used in the receivebeamformer 18. Analog ultrasound systems frequently use a heterodyne technique to shift radio frequency pulses generated by the transducer down to an intermediate frequency, e.g. 1-3 MHz. See for example Maslak U.S. Pat. No. 4,140,022, and Pummer U.S. Pat. No. 5,218,869. If a narrow bandpass filter is employed on an intermediate frequency signal of 2 MHz, a time-varying bandpass filter will be formed which only passes components corresponding to the original components of 7 MHz down to 3 MHz as the local oscillator is varied from 9 MHz to 5 MHz. A time-varying local oscillator may be realized by using a voltage controlled oscillator circuit, where the voltage determining the desired local oscillator frequency is derived via a digital-to-analog converter from a value supplied by the system computer controller.
A time-varying, sinusoidal-frequency waveform may also be generated using any one of a number of digital synthesizer techniques. See W. F. Egan, "Frequency Synthesis by Phase Lock", Krieger, 1990.
Digital filtering can also be used in the receive beamformer. A digitized signal may be shifted using quadrature sampling and sample decimation. Fine shifts in frequency are achieved by means of complex multiplication with an appropriate complex exponential exp(j*2*π*t*f0), where f0 is the amount of shift in frequency. The amount of frequency downshifting can be varied as a function of time and therefore range. Varying the degree of frequency shifting of the signal with respect to a fixed-frequency bandpass filter results in a time-varying portion of the original signal spectrum being passed. A fixed finite impulse response (FIR) bandpass or low-pass filter is applied to the data to yield a net response equivalent to a time-varying filter.
It is anticipated that the receive beamformer described in Wright, et al. U.S. patent application Ser. No. 08/286,658, filed Aug. 5, 1994 and assigned to the assignee of the present invention can be adapted for use with this invention.
Other Applications
It should be understood that the applications discussed above have been provided only by way of example. The present invention can be adapted to a wide range of applications, and is not to be limited to the specific applications discussed in this specification.
For example, the present invention is well suited for use in multiple beam systems, as well as in systems that downshift frequency for off-axis scan lines. Wright, et al. U.S. patent application Ser. No. 08/286,524, filed Aug. 5, 1994, and assigned to the assignee of the present invention, describes such systems in detail.
This invention may also be used in conjunction with non-linear contrast agents, as described by B. Schrope, et al. ("Simulated Capillary Blood Flow Measurement Using a Nonlinear Ultrasonic Contrast Agent," Ultrasonic Imaging, 14, 134-152 (1992)). These agents possess a resonant frequency and, when subjected to high pressure intensity at this frequency, will cause acoustic pressure waves to be emitted at the second, or higher, harmonic of the fundamental transmitted frequency. In the receive signal path, echoes at the fundamental frequency are filtered out to produce an image of only the contrast agents--which typically follows closely the flow of blood through the medium of interest. In transmission, the bandwidth of the emitted signal is controlled so that practically no second harmonic energy is transmitted, which would result in echoes being received which would be indistinguishable from the desired second harmonic contrast agent induced signals. The present invention is of particular importance in this application, since it permits a high acoustic pressure to be maintained over a greater depth of field than in a fixed focus system. Maintaining the acoustic pressure at high safe levels is preferred, since at these pressures the second harmonic non-linear generation is most effective. In the present invention one might transmit 3 MHz energy to a deep focus and 3.5 MHz energy to a more shallow focus. In receive, a time-varying filter would first detect signals at 7 MHz and then vary downwards in frequency to detect signals at 6 MHz.
Further Best Mode Details
As described above, a wide variety of waveforms can be used, depending upon the particular application. The following discussion focuses on one preferred embodiment, and is not intended to be limiting.
For this example the transducer is assumed to be a 5 MHz, 128 element, 0.15 millimeter pitch transducer. The original transmit pulse is a 150% bandwidth Gaussian pulse, and three sections are filtered out at 3, 5, 7 MHz using a Butterworth filter. A Chebyshev, Bessel or digital finite impulse response (FIR) filter may be a suitable alternative. The resulting spectra of the three-filtered sections are shown in FIG. 16. The filter was chosen to have approximately 30% bandwidth (with respect to the center frequency) at the -6 dB points. The bandwidth and number of filter poles are constant. Generally, it is assumed that 3 MHz energy is focused at 140 mm, 5 MHz energy at 90 mm, and 7 MHz energy at 40 mm.
FIG. 17 shows the variations in focus as a function of frequency and range. At 3 MHz, the entire transducer array is focused at 140 millimeters. At 7 MHz only the center of the array is focused at 40 millimeters. The near focal point at 10 MHz is 28 millimeters.
Low-pass filtering was applied to all elements, with more filtering of the end elements as suggested above. The cutoff frequencies across the array of transducer elements varied from 9 MHz at the center of the array to 5 MHz at the end of the array. The element-to-element function for determining the cutoff was linear. FIG. 18 illustrates the spectra of the elements extending from the center to the end of the transducer array. Half circle amplitude apodization has also been applied. The minimum amplitude level at the ends is 0.2, though it could be lowered to further suppress side lobes. FIG. 19 is a contour plot illustrating the data of FIG. 18.
FIG. 20 illustrates waveforms to be applied to the end transducer, a transducer midway between the end and the center, and the center transducer. A very substantial reduction in ringdown is readily evident. The duration of the pulse is limited more by the near focal zone delay profile than by ringdown.
FIG. 21 illustrates the result when incremental delays are applied to successive frequency components. In this case the delay is 0.27 microseconds between 3 MHz and 7 MHz. The transfer of high frequency energy toward the temporal waveform center of the central element pulse is evident, as shown by the asterisk. The total duration of the pulses is approximately 1.5 microseconds.
FIG. 22 illustrates a focal range versus frequency plot. Over the useful range (3-7 MHz) the focal range changes linearly. The receive bandpass filter ideally starts at a center frequency of 7 MHz and continues at 7 MHz until t=2·40 mm/c. Thereafter, the center frequency decreases with range linearly until it reaches 3 MHz at t=2·140 mm/c. At that point the downward ramp stops and remains at 3 MHz. Level regions at the beginning and end of the scan line minimize the loss of useful signal. The slope may be modified in practice to accommodate the frequency downshift versus time due to body attenuation. Although the variation of focal range with respect to frequency is linear over the primary operating range in FIG. 22, other functions describing the relationship between focal range and frequency, which may result in better overall performance, may be derived by analysis or experimentation. As an example, since focusing delays are approximately related to the inverse of the focal range, it may be preferable to make focal range an inverse function of frequency so that range change is greatest where the resulting delay changes are smallest.
FIG. 23 illustrates a graph of an ultrasonic scan line that is focused so that after bandpass filtering it follows an arc ofradius 500 mm.
In general, the maximum intensity should be at the deeper focal zones, where the signal-to-noise ratio is the lowest. This can be accomplished by skewing the Gaussian spectrum described above by low-pass filtering it to emphasize low frequency energy at the expense of 5 and 7 MHz energy. A suitable filter is a 4 pole, 3.5 MHz Butterworth low-pass filter. When such a filtered Gaussian was used, the maximum intensity was achieved at 140 mm.
More complicated filter approaches can be used. For example, in a situation where the peak intensity is at the 5 MHz focus, one may replace the pure Gaussian spectrum discussed above with one having a flat top and a Gaussian-like roll-off. See FIG. 24. In this way good performance can be maintained at both 3 MHz and 7 MHz.
The attached appendix provides a listing of digitized sample values of 16 transmit waveforms suitable for use fortransducer elements 0, 4, 8 . . . 60 of the linear array described above, focused perpendicularly to the transducer array. The waveforms for intermediate transducer elements may be found using the interpolation scheme described above. Also, the waveforms for elements 67 to 127 may be found from the mirror image of the data shown forelements 0 to 60, i.e., Channel 127=Channel 0, Channel 123=Channel 4, etc. Channels 61-66 may use the values forChannel 60 since the variation among center channels is negligible. See the difference betweenChannels 60 and 56. In the appendix, row A lists thetransducer numbers 0, 4, 8 . . . 3C(Hex), rows B and C list the delay values for each respective waveform in hex, and rows 00-3F list 64 successive values for each waveform, when read as a column. The delay values of rows B and C assume 200(Hex) is zero, and 0-1FF(Hex) are consecutive negative integers. The waveform values of rows 00-3F are linear, with 80(Hex) equal to zero, and 81-FF(Hex) equal to positive integers and 0-7F(Hex) equal to negative integers. The appendix assumes a clock rate of 40 MHz. In this case 64 memory samples are just sufficient. In a commercial design, considerable flexibility is offered when the memory size is increased to 128 samples.
Conclusion
The systems described above provide a number of important advantages. Since the transmit beamformers provide a line focus rather than a point focus, there is a reduced requirement for user fine tuning. This can reduce or eliminate the need for a user to select the correct focal depth or to resort to multi-zone imaging. These systems can give highly advantageous resolution at high frame rates without resorting to multi-zone techniques. By eliminating or reducing the need for multi-zone techniques, frame rates are increased and image artifact problems associated with the need to combine images are reduced. There is the potential for increased net transmitted power without exceeding peak intensity limits in view of the use of a line focus.
Of course, it should be understood that many changes and modifications can be made to the preferred embodiments described above. This invention is not limited to use with ultrasonic beamformers, but can also be adapted for use in sonar, radar, and other applications. It is therefore intended that the foregoing detailed description be regarded as illustrative rather than limiting, and that it be understood that it is the following claims, including all equivalents, that are intended to define the scope of this invention.
                                  APPENDIX__________________________________________________________________________Row A 00 04 08 0C 10 14 18 1C 20 24 28 2C 30 34 38 3CB     1E6   1E2   1DE   1DA   1D6   1D5   1D5   1D5C        1E4   1E0   1DC   1D8   1D6   1D5   1D5   1D5__________________________________________________________________________Row 00      82 81 80 80 7F 7E 7D 7D 7C 7C 7C 7C 7C 7C 7C 7C    01      7F 7E 7E 7E 7E 7D 7D 7D 7C 7C 7C 7C 7C 7C 7C 7C    02      7C 7C 7C 7D 7D 7D 7D 7C 7C 7C 7B 7B 7B 7B 7B 7B    03      7D 7D 7E 7E 7E 7E 7D 7C 7B 7B 7B 7B 7B 7B 7B 7B    04      82 82 81 80 7F 7E 7D 7B 7B 7B 7B 7B 7B 7B 7B 7A    05      84 83 82 80 7E 7D 7C 7B 7A 7A 7A 7A 7A 7A 7A 7A    06      7F 7F 7E 7D 7C 7B 7B 7A 7A 7A 7A 7A 7A 7A 7A 7A    07      79 79 79 79 7A 7A 7B 7B 7B 7A 7A 7A 7A 7A 7A 7A    08      7A 79 79 7A 7B 7B 7B 7B 7B 7B 7B 7B 7A 7A 7A 7A    09      80 80 80 7F 7E 7D 7C 7B 7B 7B 7B 7B 7B 7B 7B 7B    0A      85 85 84 81 7F 7D 7B 7B 7B 7B 7C 7B 7B 7B 7B 7B    0B      81 80 7F 7E 7C 7B 7A 7A 7C 7C 7C 7C 7C 7C 7C 7C    0C      78 76 76 76 77 78 79 7B 7D 7C 7D 7D 7D 7D 7C 7C    0D      76 74 74 75 77 79 7B 7D 7E 7D 7E 7E 7E 7D 7D 7D    0E      7D 7D 7C 7C 7D 7D 7E 7F 7F 7F 7F 7F 7F 7F 7F 7F    0F      83 85 86 84 82 80 7F 7F 80 80 81 80 80 80 80 80    10      83 83 83 82 80 7E 7D 7E 80 81 82 82 82 81 81 81    11      7C 78 77 77 78 79 7B 7E 82 82 83 83 83 83 83 83    12      76 72 70 71 74 78 7D 81 85 84 85 85 85 85 85 85    13      77 78 78 79 7C 7F 83 86 88 86 87 87 87 86 86 86    14      7E 82 86 88 88 88 88 88 88 88 89 89 89 88 88 88    15      84 86 89 8B 8A 88 86 86 88 8A 8B 8B 8B 8A 8A 8A    16      83 82 80 7F 7F 7F 81 84 89 8B 8D 8D 8D 8C 8C 8C    17      7D 79 75 73 74 79 7F 87 8D 8C 8E 8E 8E 8E 8E 8E    18      77 75 75 77 7A 80 88 8E 92 8F 90 90 90 90 90 90    19      78 7A 80 87 8D 91 94 95 94 92 92 92 91 92 92 92    1A      80 85 8C 92 97 98 96 92 90 93 93 93 93 93 93 93    1B      88 8C 8E 8E 8E 8C 8B 8A 8C 92 92 93 93 93 93 93    1C      89 89 86 81 7D 7D 81 88 8E 8F 90 92 92 92 93 93    1D      82 7F 7C 7A 7A 7F 88 91 94 8E 8D 8F 90 90 91 91    1E      7A 78 79 80 8A 93 9B 9C 94 8F 8A 8B 8C 8D 8D 8D    1F      79 7D 84 90 9C A4 A4 9A 88 8D 85 85 86 87 87 87    20      82 8B 95 9C A0 9E 94 85 74 83 7B 7D 7E 7E 7F 7F    21      8E 97 9C 9B 93 87 7A 70 67 72 6C 71 73 74 74 74    22      94 97 94 8C 82 77 71 6E 68 63 5D 62 66 67 68 68    23      8E 8B 83 7C 7A 7C 7F 7B 6A 5C 53 55 58 5A 5B 5B    24      82 7C 79 7A 83 8D 8D 7A 5A 5A 50 4D 4E 4F 50 4F    25      79 79 7F 8A 94 93 80 5B 3D 53 50 4D 4B 4A 4A 4A    26      7C 85 92 9D 9A 81 57 32 35 49 56 56 52 50 4F 4E    27      8A 98 A2 9E 86 5B 30 29 5F 4E 6C 6B 67 63 61 61    28      9A A3 9E 85 5C 34 29 54 AE 78 9A 8E 89 84 82 82    29      9F 9A 82 5B 34 27 4B 9E EF C0 D5 BE B4 AF AC AC    2A      92 7C 59 37 29 44 8A DB F5 F9 F9 E7 DB D5 D3 D3    2B      77 59 3A 2E 45 80 C8 EC C1 F4 E1 EC E9 E6 E5 E6    2C      5C 41 36 48 7B BC E5 CE 79 AF 90 BA CB D0 D3 D4    2D      4D 42 50 79 B1 DA D3 94 46 59 39 63 83 93 99 9A    2E      51 5A 7B A9 CE CE A0 5C 3A 2B 17 1C 33 45 4D 4D    2F      66 7E A2 C2 C7 A6 6C 41 4E 35 39 16 0E 13 16 16    30      81 9D B7 BE A7 79 4F 4B 73 5F 78 50 2E 1E 19 18    31      96 AB B3 A4 81 5B 50 6A 91 87 A2 99 7C 63 57 57    32      A0 A8 9F 85 66 57 64 86 9A 9B A5 B8 BA AF A6 A7    33      9D 99 87 6E 5F 64 7C 92 90 9B 93 A6 BE CB CE CE    34      92 86 74 66 67 77 8B 8F 80 8C 80 82 94 A8 B4 B4    35      85 78 6D 6B 74 84 8D 85 78 7B 74 6F 6B 72 79 79    36      7B 72 6F 74 80 88 86 7C 77 73 72 70 64 59 56 55    37      77 73 75 7D 85 86 7F 79 7B 76 78 78 74 69 61 61    38      77 77 7C 82 84 81 7C 7B 7F 7E 80 7E 83 83 80 80    39      79 7C 80 83 82 7E 7C 7E 81 82 84 83 85 8B 8F 8F    3A      7C 7F 81 82 7F 7D 7D 80 80 82 82 84 82 84 88 88    3B      7F 80 81 80 7E 7D 7E 80 7F 80 7F 81 80 7E 7D 7D    3C      80 80 80 7E 7D 7E 7F 7F 7F 7F 7E 7E 7F 7E 7B 7B    3D      80 7F 7F 7E 7E 7F 7F 7F 80 7F 7F 7E 7E 7F 7F 7F    3E      7F 7F 7E 7E 7F 7F 80 80 80 80 80 7F 7F 80 81 81    3F      7F 7E 7E 7E 7F 80 80 80 80 80 81 81 80 80 80 80__________________________________________________________________________

Claims (15)

I claim:
1. An ultrasonic imaging system comprising:
a transducer array;
a transmit waveform generator coupled to the transducer array to cause the transducer array to emit a signal having a bandwidth controlled such that substantially no second harmonic energy is transmitted, said signal having an envelope that gradually rises and falls; and
a receiver coupled to the transducer array and selectively responsive to second harmonic echo information.
2. An ultrasonic imaging system comprising:
a transducer array;
a transmit waveform generator coupled to the transducer array to cause the transducer array to emit a signal having a bandwidth controlled such that substantially no second harmonic energy is transmitted; and
a receiver coupled to the transducer array and selectively responsive to second harmonic echo information;
wherein the receiver comprises a time-varying frequency filter responsive to the second harmonic echo information.
3. The invention of claim 2 wherein the time varying filter processes arriving signals at frequencies at which substantially no energy is transmitted by the transducer.
4. An ultrasonic imaging system comprising:
a transducer array;
a transmit waveform generator coupled to the transducer array to cause the transducer array to emit a signal having a bandwidth controlled such that substantially no second harmonic energy is transmitted; and
a receiver coupled to the transducer array and selectively responsive to second harmonic echo information;
wherein the transmit generator generates transmit waveforms selected to focus higher frequencies at shorter ranges and lower frequencies at longer ranges.
5. An ultrasonic imaging method comprising:
(a) transmitting ultrasonic energy at a fundamental frequency into a tissue while controlling bandwidth of the transmitted ultrasonic energy to substantially prevent transmission of ultrasonic energy at a second harmonic of the fundamental frequency, said transmittal ultrasonic energy transmitted in pulses having an envelope that gradually rises and falls; and
(b) receiving ultrasonic echo information at the second harmonic from the tissue, while filtering out ultrasonic echo information at the fundamental frequency.
6. An ultrasonic imaging method comprising:
(a) transmitting ultrasonic energy at a fundamental frequency into a tissue while controlling bandwidth of the transmitted ultrasonic energy to substantially prevent transmission of ultrasonic energy at a second harmonic of the fundamental frequency; and
(b) receiving ultrasonic echo information at the second harmonic from the tissue, while filtering out ultrasonic echo information at the fundamental frequency;
wherein the receiving step (b) comprises the step of using a time-varying frequency filter to filter out ultrasonic echo information at the fundamental frequency.
7. An ultrasonic imaging method comprising:
(a) transmitting ultrasonic energy at a fundamental frequency into a tissue while controlling bandwidth of the transmitted ultrasonic energy to substantially prevent transmission of ultrasonic energy at a second harmonic of the fundamental frequency; and
(b) receiving ultrasonic echo information at the second harmonic from the tissue, while filtering out ultrasonic echo information at the fundamental frequency;
wherein the transmitting step (a) comprises the steps of focusing higher frequency components of the transmitted ultrasonic energy at shorter ranges and lower frequency components of the transmitted ultrasonic energy at longer ranges.
8. An ultrasonic imaging method comprising:
(a) using a transmit waveform generator comprising a programmable waveform memory to transmit ultrasonic energy at a fundamental frequency into a tissue while controlling bandwidth of the transmitted ultrasonic energy to substantially prevent transmission of ultrasonic energy at a second harmonic of the fundamental frequency; and
(b) receiving ultrasonic echo information at the second harmonic from the tissue, while filtering out ultrasonic echo information at the fundamental frequency.
9. The method of claim 7 wherein the transmitting step (a) further comprises the step of applying transmit waveforms to a transducer array comprising a central transducer, wherein at least some of the lower frequency components of the transmitted ultrasonic energy associated with the central transducer occur earlier in time than at least some of the higher frequency components of the transmitted ultrasonic energy associated with the central transducer.
10. An ultrasonic imaging system comprising:
a transmit waveform generator operative to generate a square wave burst;
a low pass filter responsive to the square wave burst to remove the harmonics and to form a smoothed waveform; and
a transducer responsive to the smoothed waveform.
11. The invention of claim 10 wherein the square wave burst is characterized by a period between successive transitions that determines a fundamental frequency.
12. An ultrasonic imaging system comprising:
a transducer array;
a transmit waveform generator comprising a programmable waveform memory coupled with the transducer array to cause the transducer array to emit a signal having a bandwidth controlled such that substantially no second harmonic energy is transmitted; and
a receiver coupled to the transducer array and selectively responsive to second harmonic echo information.
13. The invention of claim 12 wherein the transmit waveform generator further comprises a low pass filter responsive to the waveform memory and coupled to the transducer array.
14. The method of claim 8 wherein step (a) comprises the step of low pass filtering signals derived from the waveform memory.
15. The method of claim 8 further comprising the step of providing a contrast agent in the tissue during steps (a) and (b).
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US09/103,320US6027448A (en)1995-03-021998-06-23Ultrasonic transducer and method for harmonic imaging
US09/307,491US6122222A (en)1995-03-021999-05-07Ultrasonic transmit and receive system
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US08/397,833US5608690A (en)1995-03-021995-03-02Transmit beamformer with frequency dependent focus
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US08/771,345Expired - LifetimeUS5696737A (en)1995-03-021996-12-16Transmit beamformer with frequency dependent focus
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US6108273A (en)*1995-03-022000-08-22Acuson CorporationTransmit beamformer with frequency dependent focus
US20060058677A1 (en)*2002-04-262006-03-16Kazutaka OkadaUltrasonograph
US20240000422A1 (en)*2012-12-282024-01-04Philips Image Guided Therapy CorporationIntravascular ultrasound imaging apparatus, interface architecture, and method of manufacturing

Families Citing this family (163)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
DE3829999A1 (en)*1988-09-011990-03-15Schering Ag ULTRASONIC METHOD AND CIRCUITS THEREOF
US5743855A (en)*1995-03-031998-04-28Acuson CorporationBroadband phased array transducer design with frequency controlled two dimension capability and methods for manufacture thereof
US5675554A (en)*1994-08-051997-10-07Acuson CorporationMethod and apparatus for transmit beamformer
DE19581718T5 (en)*1994-08-052013-11-07Siemens Medical Solutions USA, Inc. (n.d. Ges. d. Staates Delaware) Method and apparatus for transmit beamformer system
US5540909A (en)*1994-09-281996-07-30Alliance Pharmaceutical Corp.Harmonic ultrasound imaging with microbubbles
US6126600A (en)*1994-12-022000-10-03Oxaal; John TUltrasound image assisted administering of medication
GB9425577D0 (en)*1994-12-191995-02-15Power JeffreyAcoustic transducers with controlled directivity
US6104670A (en)*1995-03-022000-08-15Acuson CorporationUltrasonic harmonic imaging system and method
US6122223A (en)*1995-03-022000-09-19Acuson CorporationUltrasonic transmit waveform generator
US6005827A (en)1995-03-021999-12-21Acuson CorporationUltrasonic harmonic imaging system and method
US6027448A (en)*1995-03-022000-02-22Acuson CorporationUltrasonic transducer and method for harmonic imaging
US6009046A (en)*1995-03-021999-12-28Acuson CorporationUltrasonic harmonic imaging system and method
US5833613A (en)1996-09-271998-11-10Advanced Technology Laboratories, Inc.Ultrasonic diagnostic imaging with contrast agents
WO1997032277A1 (en)*1996-02-291997-09-04Acuson CorporationMultiple ultrasound image registration system, method and transducer
GB9611801D0 (en)*1996-06-061996-08-07Univ BristolApparatus for and method of detecting a reflector with a medium
US5846202A (en)*1996-07-301998-12-08Acuson CorporationUltrasound method and system for imaging
US5908389A (en)*1996-09-271999-06-01Atl Ultrasound, Inc.Ultrasonic diagnostic imaging of harmonic frequencies with speckle reduction processing
US5879303A (en)*1996-09-271999-03-09Atl UltrasoundUltrasonic diagnostic imaging of response frequency differing from transmit frequency
US6283919B1 (en)1996-11-262001-09-04Atl UltrasoundUltrasonic diagnostic imaging with blended tissue harmonic signals
US7104956B1 (en)*1996-11-082006-09-12Research Corporation Technologies, Inc.Finite amplitude distortion-based inhomogeneous pulse echo ultrasonic imaging
US6458083B1 (en)1996-11-262002-10-01Koninklijke Philips Electronics N.V.Ultrasonic harmonic imaging with adaptive image formation
US6030344A (en)*1996-12-042000-02-29Acuson CorporationMethods and apparatus for ultrasound image quantification
US5891038A (en)*1996-12-301999-04-06General Electric CompanyMethod, apparatus and applications for combining transmit wave functions to obtain synthetic waveform in ultrasonic imaging system
US5720708A (en)*1997-01-021998-02-24Mayo Foundation For Medical Education And ResearchHigh frame rate imaging with limited diffraction beams
KR100252727B1 (en)*1997-02-042000-04-15이민화 Focus Delay Calculation Method and Device for Real-time Digital Focusing
US5923617A (en)*1997-02-051999-07-13The United States Of America As Represented By The Secretary Of The NavyFrequency-steered acoustic beam forming system and process
US6110120A (en)*1997-04-112000-08-29Acuson CorporationGated ultrasound imaging apparatus and method
US5882306A (en)*1997-04-111999-03-16Acuson CorporationUltrasound imaging methods and systems
US6050944A (en)*1997-06-172000-04-18Acuson CorporationMethod and apparatus for frequency control of an ultrasound system
US6193659B1 (en)1997-07-152001-02-27Acuson CorporationMedical ultrasonic diagnostic imaging method and apparatus
US5833614A (en)*1997-07-151998-11-10Acuson CorporationUltrasonic imaging method and apparatus for generating pulse width modulated waveforms with reduced harmonic response
US5913823A (en)*1997-07-151999-06-22Acuson CorporationUltrasound imaging method and system for transmit signal generation for an ultrasonic imaging system capable of harmonic imaging
EP1624318A3 (en)1997-07-152009-06-24Acuson CorporationUltrasonic harmonic imaging system and method
US6023977A (en)*1997-08-012000-02-15Acuson CorporationUltrasonic imaging aberration correction system and method
US6132374A (en)*1997-08-012000-10-17Acuson CorporationUltrasonic imaging method and system
US6312379B1 (en)*1997-08-152001-11-06Acuson CorporationUltrasonic harmonic imaging system and method using waveform pre-distortion
US5944666A (en)*1997-08-211999-08-31Acuson CorporationUltrasonic method for imaging blood flow including disruption or activation of contrast agent
US5928151A (en)*1997-08-221999-07-27Acuson CorporationUltrasonic system and method for harmonic imaging in three dimensions
US6106465A (en)*1997-08-222000-08-22Acuson CorporationUltrasonic method and system for boundary detection of an object of interest in an ultrasound image
US5873830A (en)*1997-08-221999-02-23Acuson CorporationUltrasound imaging system and method for improving resolution and operation
US5935069A (en)*1997-10-101999-08-10Acuson CorporationUltrasound system and method for variable transmission of ultrasonic signals
US5860931A (en)*1997-10-101999-01-19Acuson CorporationUltrasound method and system for measuring perfusion
US5931785A (en)*1997-10-301999-08-03Hewlett-Packard CompanyUltrasonic transducer having elements arranged in sections of differing effective pitch
US5980457A (en)*1997-11-171999-11-09Atl Ultrasound, Inc.Ultrasonic transmit pulses for nonlinear ultrasonic imaging
US5897500A (en)*1997-12-181999-04-27Acuson CorporationUltrasonic imaging system and method for displaying composite fundamental and harmonic images
US5891037A (en)*1997-12-181999-04-06Acuson CorporationUltrasonic Doppler imaging system with frequency dependent focus
US5935070A (en)*1997-12-311999-08-10Analogic CorporationMethod and apparatus for delaying ultrasound signals
US6176829B1 (en)*1998-02-262001-01-23Echocath, Inc.Multi-beam diffraction grating imager apparatus and method
US5984869A (en)*1998-04-201999-11-16General Electric CompanyMethod and apparatus for ultrasonic beamforming using golay-coded excitation
US6102858A (en)*1998-04-232000-08-15General Electric CompanyMethod and apparatus for three-dimensional ultrasound imaging using contrast agents and harmonic echoes
US6036643A (en)*1998-05-142000-03-14Advanced Technology Laboratories, Inc.Ultrasonic harmonic doppler imaging
US6511426B1 (en)1998-06-022003-01-28Acuson CorporationMedical diagnostic ultrasound system and method for versatile processing
US6116244A (en)*1998-06-022000-09-12Acuson CorporationUltrasonic system and method for three-dimensional imaging with opacity control
US5957852A (en)*1998-06-021999-09-28Acuson CorporationUltrasonic harmonic imaging system and method
US5971925A (en)*1998-06-081999-10-26Acuson CorporationBroadband phased array transducer with frequency controlled two dimensional aperture capability for harmonic imaging
US5976091A (en)*1998-06-081999-11-02Acuson CorporationLimited diffraction broadband phased array transducer with frequency controlled two dimensional aperture capability
US5961464A (en)*1998-09-161999-10-05Hewlett-Packard CompanyUltrasound contrast agent detection using spectral analysis from acoustic scan lines
US6544177B1 (en)1998-10-012003-04-08Atl Ultrasound, Inc.Ultrasonic diagnostic imaging system and method with harmonic spatial compounding
US6048316A (en)*1998-10-162000-04-11Acuson CorporationMedical diagnostic ultrasonic imaging system and method for displaying composite fundamental and harmonic images
US6042545A (en)*1998-11-252000-03-28Acuson CorporationMedical diagnostic ultrasound system and method for transform ultrasound processing
US6234967B1 (en)1998-12-182001-05-22Atl UltrasoundUltrasonic diagnostic imaging systems with power modulation for contrast and harmonic imaging
GB9901270D0 (en)1999-01-211999-03-10Quadrant Healthcare Uk LtdMethod and apparatus for ultrasound contrast imaging
US6213951B1 (en)1999-02-192001-04-10Acuson CorporationMedical diagnostic ultrasound method and system for contrast specific frequency imaging
US6312386B1 (en)1999-02-192001-11-06Acuson CorporationMedical ultrasound imaging system with composite delay profile
US6120448A (en)*1999-02-222000-09-19Acuson CorporationDiagnostic medical ultrasonic imaging method and system for selectively processing harmonic and fundamental image information
US6168565B1 (en)1999-03-312001-01-02Acuson CorporationMedical diagnostic ultrasound system and method for simultaneous phase correction of two frequency band signal components
US6213947B1 (en)1999-03-312001-04-10Acuson CorporationMedical diagnostic ultrasonic imaging system using coded transmit pulses
US6132377A (en)*1999-03-312000-10-17Acuson CorporationMedical diagnostic ultrasonic imaging system and method using differential sub-band detection techniques
US6117082A (en)*1999-03-312000-09-12Acuson CorporationMedical diagnostic ultrasound imaging system and method with fractional harmonic seed signal
US6241674B1 (en)1999-03-312001-06-05Acuson CorporationMedical ultrasound diagnostic imaging method and system with nonlinear phase modulation pulse compression
US6292435B1 (en)1999-05-112001-09-18Agilent Technologies, Inc.Circuit and method for exciting a micro-machined transducer to have low second order harmonic transmit energy
US6241676B1 (en)1999-06-102001-06-05Agilent Technologies, Inc.Ultrasound transmit waveforms having low harmonic content
US6423002B1 (en)1999-06-242002-07-23Acuson CorporationIntra-operative diagnostic ultrasound multiple-array transducer probe and optional surgical tool
US6685645B1 (en)2001-10-202004-02-03Zonare Medical Systems, Inc.Broad-beam imaging
US6740039B1 (en)1999-08-202004-05-25Koninklijke Philips Electronics N.V.Methods and apparatus for displaying information relating to delivery and activation of a therapeutic agent using ultrasound energy
US6527718B1 (en)1999-08-202003-03-04Brian G ConnorUltrasound system for continuous imaging and delivery of an encapsulated agent
US6896658B2 (en)*2001-10-202005-05-24Zonare Medical Systems, Inc.Simultaneous multi-mode and multi-band ultrasonic imaging
US6277073B1 (en)1999-09-232001-08-21Acuson CorporationMedical diagnostic ultrasound imaging method and system using simultaneously transmitted ultrasound beams
US6461299B1 (en)1999-12-222002-10-08Acuson CorporationMedical diagnostic ultrasound system and method for harmonic imaging with an electrostatic transducer
US6409667B1 (en)2000-02-232002-06-25Acuson CorporationMedical diagnostic ultrasound transducer system and method for harmonic imaging
US6532819B1 (en)2000-02-292003-03-18Jie ChenWideband piezoelecric transducer for harmonic imaging
US6494841B1 (en)*2000-02-292002-12-17Acuson CorporationMedical diagnostic ultrasound system using contrast pulse sequence imaging
JP3947647B2 (en)*2000-03-282007-07-25松下電器産業株式会社 Ultrasonic diagnostic equipment
EP1146351A1 (en)*2000-04-122001-10-17Bracco Research S.A.Ultrasound contrast imaging with double-pulse excitation waveforms
US6443901B1 (en)2000-06-152002-09-03Koninklijke Philips Electronics N.V.Capacitive micromachined ultrasonic transducers
US6425869B1 (en)2000-07-182002-07-30Koninklijke Philips Electronics, N.V.Wideband phased-array transducer for uniform harmonic imaging, contrast agent detection, and destruction
US6551244B1 (en)*2000-10-172003-04-22Acuson CorporationParametric transmit waveform generator for medical ultrasound imaging system
US6464636B1 (en)2000-10-182002-10-15Koninklijke Philips Electronics N.V.Configuration tool for use in ultrasound imaging device
US6469957B1 (en)2000-10-182002-10-22Koninklijke Philips Electronics N.V.Arbitrary signal generator for driving ultrasonic transducers
JP2002136522A (en)*2000-11-022002-05-14Japan Science & Technology Corp Ultrasonic measuring device
US6611230B2 (en)2000-12-112003-08-26Harris CorporationPhased array antenna having phase shifters with laterally spaced phase shift bodies
US6421023B1 (en)2000-12-112002-07-16Harris CorporationPhase shifter and associated method for impedance matching
US6592524B2 (en)*2000-12-222003-07-15Siemens Medical Solutions Usa, Inc.Transmit beamformer delay architecture and method for diagnostic medical ultrasound
US6678209B1 (en)2001-11-212004-01-13Luc PengApparatus and method for detecting sonar signals in a noisy environment
JP4022393B2 (en)*2001-12-122007-12-19株式会社日立メディコ Ultrasonic diagnostic equipment
KR100406098B1 (en)*2001-12-262003-11-14주식회사 메디슨Ultrasound imaging system and method based on simultaneous multiple transmit-focusing using the weighted orthogonal chirp signals
FR2835317B1 (en)*2002-01-282004-07-23Coflexip METHOD AND DEVICE FOR ECHOGRAPHIC MONITORING OF PLASTIC TUBULAR SHEATH
US6685641B2 (en)2002-02-012004-02-03Siemens Medical Solutions Usa, Inc.Plane wave scanning reception and receiver
US6783497B2 (en)2002-05-232004-08-31Volumetrics Medical Imaging, Inc.Two-dimensional ultrasonic array with asymmetric apertures
ITSV20020058A1 (en)*2002-11-282004-05-29Esaote Spa METHOD AND DEVICE FOR THE FORMATION OF BEAMS OF ACOUSTIC WAVES, IN PARTICULAR ULTRASOUND AND IN A SPECIAL WAY FOR
FR2853075B1 (en)*2003-03-242005-06-10Centre Nat Rech Scient METHOD FOR DETERMINING IMPULSE RESPONSES OF A MEDIUM FOR TRANSMISSION OF WAVES BETWEEN DIFFERENT POINTS
US6960169B2 (en)*2003-05-192005-11-01Siemens Medical Solutions Usa, Inc.Spread spectrum coding for ultrasound contrast agent imaging
JP2005082025A (en)*2003-09-092005-03-31Takata CorpAir bag, and air bag assembly
US20050107694A1 (en)*2003-11-172005-05-19Jansen Floribertus H.Method and system for ultrasonic tagging of fluorescence
US7833163B2 (en)2003-12-102010-11-16Siemens Medical Solutions Usa, Inc.Steering angle varied pattern for ultrasound imaging with a two-dimensional array
US7105981B2 (en)*2003-12-102006-09-12Siemens Medical Solutions Usa, Inc.Medical imaging transmit spectral control using aperture functions
CN1977186A (en)*2004-06-302007-06-06皇家飞利浦电子股份有限公司 Nonlinear Ultrasonic Diagnostic Imaging Using Intermodulation Component Signals
US7289390B2 (en)*2004-07-192007-10-30Furuno Electric Company, LimitedUltrasonic transmitting/receiving apparatus and scanning sonar employing same
US7004906B1 (en)*2004-07-262006-02-28Siemens Medical Solutions Usa, Inc.Contrast agent imaging with agent specific ultrasound detection
US7957609B2 (en)*2005-08-292011-06-07The University Of ToledoSystem for extended high frame rate imaging with limited-diffraction beams
US20070149881A1 (en)*2005-12-222007-06-28Rabin Barry HUltrasonically Powered Medical Devices and Systems, and Methods and Uses Thereof
WO2007089580A2 (en)*2006-01-262007-08-09University Of ToledoHigh frame rate imagining system
US20090118619A1 (en)*2006-02-232009-05-07Mitsuhiro OshikiUltrasonic diagnostic apparatus and ultrasonic diagnostic method
JP2008000486A (en)*2006-06-232008-01-10Ge Medical Systems Global Technology Co LlcUltrasonic diagnostic device and its control method
JP4291833B2 (en)*2006-06-232009-07-08ジーイー・メディカル・システムズ・グローバル・テクノロジー・カンパニー・エルエルシー Ultrasonic diagnostic apparatus and ultrasonic diagnostic image generation method
JP5154554B2 (en)2006-08-012013-02-27ボストン サイエンティフィック サイムド,インコーポレイテッド Pulse inversion sequence for nonlinear imaging
US8946972B2 (en)*2006-08-162015-02-03Siemens Medical Solutions Usa, Inc.Layer switching for an ultrasound transducer array
US8262591B2 (en)*2006-09-072012-09-11Nivasonix, LlcExternal ultrasound lipoplasty
DE102006043411B4 (en)*2006-09-152009-11-12Innovationszentrum für Telekommunikationstechnik GmbH IZT Concept for the realistic simulation of a frequency spectrum
US20080132791A1 (en)*2006-11-302008-06-05Hastings Harold MSingle frame - multiple frequency compounding for ultrasound imaging
JP5478814B2 (en)*2007-06-052014-04-23株式会社東芝 Ultrasonic diagnostic apparatus and ultrasonic speed measurement method
US20090076394A1 (en)*2007-06-292009-03-19William WongHigh-frequency tissue imaging devices and methods
JP2009028366A (en)*2007-07-272009-02-12Toshiba Corp Ultrasonic diagnostic equipment
US20090171210A1 (en)*2007-12-272009-07-02Washington University In St. LouisSonoelectric tomography using a frequency-swept ultrasonic wave
WO2010018525A1 (en)*2008-08-152010-02-18Koninklijke Philips Electronics N.V.Transducer arrangement and method for acquiring sono-elastographical data and ultrasonic data of a material
US20120179044A1 (en)*2009-09-302012-07-12Alice ChiangUltrasound 3d imaging system
US12102479B2 (en)2008-09-152024-10-01Teratech CorporationUltrasound 3D imaging system
US10080544B2 (en)2008-09-152018-09-25Teratech CorporationUltrasound 3D imaging system
US20100204582A1 (en)*2009-02-122010-08-12Xuan-Ming LuMultidimensional, multilayer ultrasound transducer probe for medical ultrasound imaging
US8300499B2 (en)2009-07-142012-10-30Navico, Inc.Linear and circular downscan imaging sonar
US9204862B2 (en)2011-07-082015-12-08General Electric CompanyMethod and apparatus for performing ultrasound elevation compounding
SG11201401833UA (en)2011-10-282014-05-29Decision Sciences Int CorpSpread spectrum coded waveforms in ultrasound imaging
US9274215B2 (en)2013-03-082016-03-01Chison Medical Imaging, Inc.Ultrasound fusion harmonic imaging systems and methods
US9844359B2 (en)2013-09-132017-12-19Decision Sciences Medical Company, LLCCoherent spread-spectrum coded waveforms in synthetic aperture image formation
US9620983B2 (en)*2013-10-012017-04-11Intel CorporationUltrasonic universal wireless charging
US9332963B2 (en)2014-01-212016-05-10Siemens Medical Solutions Usa, Inc.Swept focus for acoustic radiation force impulse
KR20160030753A (en)*2014-09-112016-03-21삼성전자주식회사Transmit beamforming apparatus, receive beamforming apparatus, ultrasound probe having the same, and method for beamforming
EP3261548B1 (en)2015-02-252021-09-08Decision Sciences Medical Company, LLCAcoustic signal transmission couplants and coupling mediums
JP6443217B2 (en)*2015-05-212018-12-26コニカミノルタ株式会社 Ultrasound diagnostic imaging equipment
US11125866B2 (en)*2015-06-042021-09-21Chikayoshi SumiMeasurement and imaging instruments and beamforming method
EP3359048B1 (en)*2015-10-082023-07-19Decision Sciences Medical Company, LLCAcoustic orthopedic tracking system and methods
CN110312477A (en)2016-09-292019-10-08精密成像有限公司Signal processing approach for ultrasound imaging apparatus
JP6273055B1 (en)*2017-01-312018-01-31株式会社日立パワーソリューションズ POSITION CONTROL DEVICE, POSITION CONTROL METHOD, AND ULTRASONIC VIDEO SYSTEM
DE112018003501T5 (en)*2017-07-092020-04-23The Board Of Trustees Of The Leland Stanford Junior University ULTRASOUND IMAGING WITH SPECTRAL COMPOUNDING FOR SPECKLE REDUCTION
US11460550B2 (en)*2017-09-192022-10-04Veoneer Us, LlcDirect detection LiDAR system and method with synthetic doppler processing
US11194022B2 (en)2017-09-292021-12-07Veoneer Us, Inc.Detection system with reflection member and offset detection array
US11585901B2 (en)2017-11-152023-02-21Veoneer Us, LlcScanning lidar system and method with spatial filtering for reduction of ambient light
US11337679B2 (en)*2018-03-272022-05-24Siemens Medical Solutions Usa, Inc.Frequency sweep for acoustic radiation force impulse
CN113613905A (en)2019-03-062021-11-05决策科学医疗有限责任公司Method for manufacturing and distributing semi-rigid acoustically coupled articles and packaging for ultrasonic imaging
US11154274B2 (en)2019-04-232021-10-26Decision Sciences Medical Company, LLCSemi-rigid acoustic coupling articles for ultrasound diagnostic and treatment applications
US11579257B2 (en)2019-07-152023-02-14Veoneer Us, LlcScanning LiDAR system and method with unitary optical element
US11474218B2 (en)2019-07-152022-10-18Veoneer Us, LlcScanning LiDAR system and method with unitary optical element
US11435461B2 (en)2019-07-192022-09-06GE Precision Healthcare LLCMethod and system to prevent depoling of ultrasound transducer
US11464494B2 (en)2019-07-192022-10-11GE Precision Healthcare LLCMethod and system to revert a depoling effect exhibited by an ultrasound transducer
US11313969B2 (en)2019-10-282022-04-26Veoneer Us, Inc.LiDAR homodyne transceiver using pulse-position modulation
CA3202517A1 (en)2020-11-132022-05-19Decision Sciences Medical Company, LLCSystems and methods for synthetic aperture ultrasound imaging of an object
US12044800B2 (en)2021-01-142024-07-23Magna Electronics, LlcScanning LiDAR system and method with compensation for transmit laser pulse effects
US11326758B1 (en)2021-03-122022-05-10Veoneer Us, Inc.Spotlight illumination system using optical element
US11732858B2 (en)2021-06-182023-08-22Veoneer Us, LlcHeadlight illumination system using optical element
US12092278B2 (en)2022-10-072024-09-17Magna Electronics, LlcGenerating a spotlight
US12228653B2 (en)2022-10-072025-02-18Magna Electronics, LlcIntegrating a sensing system into headlight optics
US20240337737A1 (en)*2023-04-102024-10-10GE Precision Healthcare LLCSystem and methods for transmission of non-diffracting acoustic beams
US12202396B1 (en)2023-12-192025-01-21Magna Electronics, LlcLine-scan-gated imaging for LiDAR headlight

Citations (62)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US3953825A (en)*1974-07-121976-04-27The Board Of Trustees Of Leland Stanford Junior UniversityElectronically focused imaging system and method
US4016750A (en)*1975-11-061977-04-12Stanford Research InstituteUltrasonic imaging method and apparatus
US4140022A (en)*1977-12-201979-02-20Hewlett-Packard CompanyAcoustic imaging apparatus
US4395912A (en)*1979-12-121983-08-02Siemens AktiengesellschaftApparatus for ultrasonic scanning
US4403311A (en)*1980-03-211983-09-06Thomson-CsfAcoustic imaging system
US4403314A (en)*1980-03-181983-09-06Thomson-CsfActive detection system using simultaneous multiple transmissions
US4446740A (en)*1982-03-091984-05-08Sri InternationalFrequency controlled hybrid ultrasonic imaging arrays
US4456982A (en)*1980-10-101984-06-26Thomson-CsfImaging system with multiple, simultaneous transmissions
US4458342A (en)*1980-11-041984-07-03Thomson-CsfDiversified transmission multichannel detection system
US4550607A (en)*1984-05-071985-11-05AcusonPhased array acoustic imaging system
US4699009A (en)*1985-11-051987-10-13AcusonDynamically focused linear phased array acoustic imaging system
US4712037A (en)*1985-07-031987-12-08Nederlandse Centrale Organisatie Voor Toegepast-Natuurwetenschappelijk OnderzoekResonant piezoelectric sensor
US4870971A (en)*1987-08-051989-10-03North American Philips CorporationTransmit focus generator for ultrasound imaging
US4974558A (en)*1982-02-031990-12-04Hitachi Medical CorporationUltrasonodiagnostic tomography apparatus
US5014712A (en)*1989-12-261991-05-14General Electric CompanyCoded excitation for transmission dynamic focusing of vibratory energy beam
US5040537A (en)*1987-11-241991-08-20Hitachi, Ltd.Method and apparatus for the measurement and medical treatment using an ultrasonic wave
US5105814A (en)*1990-08-151992-04-21Hewlett-Packard CompanyMethod of transforming a multi-beam ultrasonic image
US5111823A (en)*1989-04-201992-05-12National Fertility InstituteApparatus and method for generating echographic images
US5113706A (en)*1990-07-031992-05-19Hewlett-Packard CompanyUltrasound system with dynamic transmit focus
US5115809A (en)*1989-03-311992-05-26Kabushiki Kaisha ToshibaUltrasonic probe
US5142649A (en)*1991-08-071992-08-25General Electric CompanyUltrasonic imaging system with multiple, dynamically focused transmit beams
US5190766A (en)*1990-04-161993-03-02Ken IshiharaMethod of controlling drug release by resonant sound wave
US5195520A (en)*1986-11-051993-03-23Schering AktiengesellschaftUltrasonic manometry process in a fluid by means of microbubbles
US5215680A (en)*1990-07-101993-06-01Cavitation-Control Technology, Inc.Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles
US5218869A (en)*1992-01-141993-06-15Diasonics, Inc.Depth dependent bandpass of ultrasound signals using heterodyne mixing
US5219401A (en)*1989-02-211993-06-15Technomed Int'lApparatus for selective destruction of cells by implosion of gas bubbles
US5228007A (en)*1991-03-201993-07-13Fujitsu LimitedUltrasonic beam forming system
US5235982A (en)*1991-09-301993-08-17General Electric CompanyDynamic transmit focusing of a steered ultrasonic beam
US5255683A (en)*1991-12-301993-10-26Sound Science Limited PartnershipMethods of and systems for examining tissue perfusion using ultrasonic contrast agents
US5301674A (en)*1992-03-271994-04-12Diasonics, Inc.Method and apparatus for focusing transmission and reception of ultrasonic beams
US5322068A (en)*1993-05-211994-06-21Hewlett-Packard CompanyMethod and apparatus for dynamically steering ultrasonic phased arrays
US5358466A (en)*1991-04-151994-10-25Kabushiki Kaisha ToshibaApparatus for destroying a calculus
US5380411A (en)*1987-12-021995-01-10Schering AktiengesellschaftUltrasound or shock wave work process and preparation for carrying out same
US5410516A (en)*1988-09-011995-04-25Schering AktiengesellschaftUltrasonic processes and circuits for performing them
US5410205A (en)*1993-02-111995-04-25Hewlett-Packard CompanyUltrasonic transducer having two or more resonance frequencies
US5417214A (en)*1992-08-071995-05-23Trustees Of The University Of PennsylvaniaQuantitative blood flow measurement using steady-state transport-induced adiabatic fast passage
US5425366A (en)*1988-02-051995-06-20Schering AktiengesellschaftUltrasonic contrast agents for color Doppler imaging
US5433207A (en)*1993-11-151995-07-18Pretlow, Iii; Robert A.Method and apparatus to characterize ultrasonically reflective contrast agents
US5438554A (en)*1993-06-151995-08-01Hewlett-Packard CompanyTunable acoustic resonator for clinical ultrasonic transducers
US5456255A (en)*1993-07-121995-10-10Kabushiki Kaisha ToshibaUltrasonic diagnosis apparatus
US5456257A (en)*1994-11-231995-10-10Advanced Technology Laboratories, Inc.Ultrasonic detection of contrast agents
US5469849A (en)*1993-06-141995-11-28Kabushiki Kaisha ToshibaUltrasound diagnosis apparatus
US5479926A (en)*1995-03-101996-01-02Acuson CorporationImaging system display processor
US5482046A (en)*1994-11-231996-01-09General Electric CompanyAcoustic power control technique
US5523058A (en)*1992-09-161996-06-04Hitachi, Ltd.Ultrasonic irradiation apparatus and processing apparatus based thereon
US5526816A (en)*1994-09-221996-06-18Bracco Research S.A.Ultrasonic spectral contrast imaging
US5558092A (en)*1995-06-061996-09-24Imarx Pharmaceutical Corp.Methods and apparatus for performing diagnostic and therapeutic ultrasound simultaneously
US5560364A (en)*1995-05-121996-10-01The Board Of Regents Of The University Of NebraskaSuspended ultra-sound induced microbubble cavitation imaging
US5577505A (en)*1996-02-061996-11-26Hewlett-Packard CompanyMeans for increasing sensitivity in non-linear ultrasound imaging systems
US5579768A (en)*1995-03-211996-12-03Acuson CorporationAutomatic gain compensation in an ultrasound imaging system
US5579770A (en)*1995-05-021996-12-03Acuson CorporationMultiple transmit zone splicing
US5580575A (en)*1989-12-221996-12-03Imarx Pharmaceutical Corp.Therapeutic drug delivery systems
US5601086A (en)*1995-05-121997-02-11The United States Of America As Represented By The Administrator Of The National Aeronautics And Space AdministrationBeat frequency ultrasonic microsphere contrast agent detection system
US5608690A (en)*1995-03-021997-03-04Acuson CorporationTransmit beamformer with frequency dependent focus
US5617862A (en)*1995-05-021997-04-08Acuson CorporationMethod and apparatus for beamformer system with variable aperture
EP0770352A1 (en)*1995-10-101997-05-02Advanced Technology Laboratories, Inc.Ultrasonic diagnostic imaging with contrast agents
US5628322A (en)*1995-05-151997-05-13Kabushiki Kaisha ToshibaMethod of ultrasound imaging and diagnostic ultrasound system
US5632277A (en)*1996-06-281997-05-27Siemens Medical Systems, Inc.Ultrasound imaging system employing phase inversion subtraction to enhance the image
US5675554A (en)*1994-08-051997-10-07Acuson CorporationMethod and apparatus for transmit beamformer
US5678553A (en)*1994-11-011997-10-21Schering AktiengesellschaftUltrasonic processes and circuits for carrying out those processes
US5678554A (en)*1996-07-021997-10-21Acuson CorporationUltrasound transducer for multiple focusing and method for manufacture thereof
US5724976A (en)*1994-12-281998-03-10Kabushiki Kaisha ToshibaUltrasound imaging preferable to ultrasound contrast echography

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
JPS61228843A (en)*1985-04-041986-10-13アロカ株式会社Ultrasonic measuring method and apparatus
US4865042A (en)*1985-08-161989-09-12Hitachi, Ltd.Ultrasonic irradiation system
DE3829999A1 (en)*1988-09-011990-03-15Schering Ag ULTRASONIC METHOD AND CIRCUITS THEREOF
US5704361A (en)*1991-11-081998-01-06Mayo Foundation For Medical Education And ResearchVolumetric image ultrasound transducer underfluid catheter system
CA2110148C (en)*1992-12-241999-10-05Aaron FensterThree-dimensional ultrasound imaging system
AUPM634794A0 (en)*1994-06-211994-07-14Pacific Inks (Australia) Pty LtdSystem for mixing liquids
US5562096A (en)*1994-06-281996-10-08Acuson CorporationUltrasonic transducer probe with axisymmetric lens
US5667373A (en)*1994-08-051997-09-16Acuson CorporationMethod and apparatus for coherent image formation
US5685308A (en)*1994-08-051997-11-11Acuson CorporationMethod and apparatus for receive beamformer system
US5540909A (en)*1994-09-281996-07-30Alliance Pharmaceutical Corp.Harmonic ultrasound imaging with microbubbles
US5740808A (en)*1996-10-281998-04-21Ep Technologies, IncSystems and methods for guilding diagnostic or therapeutic devices in interior tissue regions
US5474073A (en)*1994-11-221995-12-12Advanced Technology Laboratories, Inc.Ultrasonic diagnostic scanning for three dimensional display
US5471990A (en)*1994-11-231995-12-05Advanced Technology Laboratories, Inc.Ultrasonic doppler power measurement and display system
US5485842A (en)*1994-11-301996-01-23Advanced Technology Laboratories, Inc.Ultrasonic diagnostic scan conversion for three dimensional display processing
US5546807A (en)*1994-12-021996-08-20Oxaal; John T.High speed volumetric ultrasound imaging system
US5655535A (en)*1996-03-291997-08-12Siemens Medical Systems, Inc.3-Dimensional compound ultrasound field of view
US5601085A (en)*1995-10-021997-02-11Nycomed Imaging AsUltrasound imaging
US5833613A (en)*1996-09-271998-11-10Advanced Technology Laboratories, Inc.Ultrasonic diagnostic imaging with contrast agents
US5720291A (en)*1996-03-221998-02-24Advanced Technology Laboratories, Inc.Three dimensional medical ultrasonic diagnostic image of tissue texture and vasculature
US5699805A (en)*1996-06-201997-12-23Mayo Foundation For Medical Education And ResearchLongitudinal multiplane ultrasound transducer underfluid catheter system
US5846200A (en)*1996-11-081998-12-08Advanced Technology Laboratories, Inc.Ultrasonic diagnostic imaging system for analysis of left ventricular function
DE69735927T2 (en)*1996-11-262007-05-24ATL Ultrasound, Inc., Bothell Diagnostic imaging by means of ultrasound of different transmission and reception frequencies
EP0982036A1 (en)*1998-08-282000-03-01Wilex Biotechnology GmbHModulation of Beta2 -integrin-mediated cell adhesion

Patent Citations (66)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US3953825A (en)*1974-07-121976-04-27The Board Of Trustees Of Leland Stanford Junior UniversityElectronically focused imaging system and method
US4016750A (en)*1975-11-061977-04-12Stanford Research InstituteUltrasonic imaging method and apparatus
US4016750B1 (en)*1975-11-061994-04-05Stanford Research InstUltrasonic imaging method and apparatus
US4140022A (en)*1977-12-201979-02-20Hewlett-Packard CompanyAcoustic imaging apparatus
US4140022B1 (en)*1977-12-201995-05-16Hewlett Packard CoAcoustic imaging apparatus
US4395912A (en)*1979-12-121983-08-02Siemens AktiengesellschaftApparatus for ultrasonic scanning
US4403314A (en)*1980-03-181983-09-06Thomson-CsfActive detection system using simultaneous multiple transmissions
US4403311A (en)*1980-03-211983-09-06Thomson-CsfAcoustic imaging system
US4456982A (en)*1980-10-101984-06-26Thomson-CsfImaging system with multiple, simultaneous transmissions
US4458342A (en)*1980-11-041984-07-03Thomson-CsfDiversified transmission multichannel detection system
US4974558A (en)*1982-02-031990-12-04Hitachi Medical CorporationUltrasonodiagnostic tomography apparatus
US4446740A (en)*1982-03-091984-05-08Sri InternationalFrequency controlled hybrid ultrasonic imaging arrays
US4550607A (en)*1984-05-071985-11-05AcusonPhased array acoustic imaging system
US4712037A (en)*1985-07-031987-12-08Nederlandse Centrale Organisatie Voor Toegepast-Natuurwetenschappelijk OnderzoekResonant piezoelectric sensor
US4699009A (en)*1985-11-051987-10-13AcusonDynamically focused linear phased array acoustic imaging system
US5195520A (en)*1986-11-051993-03-23Schering AktiengesellschaftUltrasonic manometry process in a fluid by means of microbubbles
US4870971A (en)*1987-08-051989-10-03North American Philips CorporationTransmit focus generator for ultrasound imaging
US5040537A (en)*1987-11-241991-08-20Hitachi, Ltd.Method and apparatus for the measurement and medical treatment using an ultrasonic wave
US5380411A (en)*1987-12-021995-01-10Schering AktiengesellschaftUltrasound or shock wave work process and preparation for carrying out same
US5425366A (en)*1988-02-051995-06-20Schering AktiengesellschaftUltrasonic contrast agents for color Doppler imaging
US5410516A (en)*1988-09-011995-04-25Schering AktiengesellschaftUltrasonic processes and circuits for performing them
US5219401A (en)*1989-02-211993-06-15Technomed Int'lApparatus for selective destruction of cells by implosion of gas bubbles
US5115809A (en)*1989-03-311992-05-26Kabushiki Kaisha ToshibaUltrasonic probe
US5111823A (en)*1989-04-201992-05-12National Fertility InstituteApparatus and method for generating echographic images
US5580575A (en)*1989-12-221996-12-03Imarx Pharmaceutical Corp.Therapeutic drug delivery systems
US5014712A (en)*1989-12-261991-05-14General Electric CompanyCoded excitation for transmission dynamic focusing of vibratory energy beam
US5190766A (en)*1990-04-161993-03-02Ken IshiharaMethod of controlling drug release by resonant sound wave
US5113706A (en)*1990-07-031992-05-19Hewlett-Packard CompanyUltrasound system with dynamic transmit focus
US5215680A (en)*1990-07-101993-06-01Cavitation-Control Technology, Inc.Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles
US5105814A (en)*1990-08-151992-04-21Hewlett-Packard CompanyMethod of transforming a multi-beam ultrasonic image
US5228007A (en)*1991-03-201993-07-13Fujitsu LimitedUltrasonic beam forming system
US5358466A (en)*1991-04-151994-10-25Kabushiki Kaisha ToshibaApparatus for destroying a calculus
US5142649A (en)*1991-08-071992-08-25General Electric CompanyUltrasonic imaging system with multiple, dynamically focused transmit beams
US5235982A (en)*1991-09-301993-08-17General Electric CompanyDynamic transmit focusing of a steered ultrasonic beam
US5255683A (en)*1991-12-301993-10-26Sound Science Limited PartnershipMethods of and systems for examining tissue perfusion using ultrasonic contrast agents
US5218869A (en)*1992-01-141993-06-15Diasonics, Inc.Depth dependent bandpass of ultrasound signals using heterodyne mixing
US5301674A (en)*1992-03-271994-04-12Diasonics, Inc.Method and apparatus for focusing transmission and reception of ultrasonic beams
US5417214A (en)*1992-08-071995-05-23Trustees Of The University Of PennsylvaniaQuantitative blood flow measurement using steady-state transport-induced adiabatic fast passage
US5523058A (en)*1992-09-161996-06-04Hitachi, Ltd.Ultrasonic irradiation apparatus and processing apparatus based thereon
US5410205A (en)*1993-02-111995-04-25Hewlett-Packard CompanyUltrasonic transducer having two or more resonance frequencies
US5322068A (en)*1993-05-211994-06-21Hewlett-Packard CompanyMethod and apparatus for dynamically steering ultrasonic phased arrays
US5469849A (en)*1993-06-141995-11-28Kabushiki Kaisha ToshibaUltrasound diagnosis apparatus
US5438554A (en)*1993-06-151995-08-01Hewlett-Packard CompanyTunable acoustic resonator for clinical ultrasonic transducers
US5456255A (en)*1993-07-121995-10-10Kabushiki Kaisha ToshibaUltrasonic diagnosis apparatus
US5433207A (en)*1993-11-151995-07-18Pretlow, Iii; Robert A.Method and apparatus to characterize ultrasonically reflective contrast agents
US5675554A (en)*1994-08-051997-10-07Acuson CorporationMethod and apparatus for transmit beamformer
US5526816A (en)*1994-09-221996-06-18Bracco Research S.A.Ultrasonic spectral contrast imaging
US5678553A (en)*1994-11-011997-10-21Schering AktiengesellschaftUltrasonic processes and circuits for carrying out those processes
US5456257A (en)*1994-11-231995-10-10Advanced Technology Laboratories, Inc.Ultrasonic detection of contrast agents
US5482046A (en)*1994-11-231996-01-09General Electric CompanyAcoustic power control technique
US5724976A (en)*1994-12-281998-03-10Kabushiki Kaisha ToshibaUltrasound imaging preferable to ultrasound contrast echography
US5696737A (en)*1995-03-021997-12-09Acuson CorporationTransmit beamformer with frequency dependent focus
US5740128A (en)*1995-03-021998-04-14Acuson CorporationUltrasonic harmonic imaging system and method
US5608690A (en)*1995-03-021997-03-04Acuson CorporationTransmit beamformer with frequency dependent focus
US5479926A (en)*1995-03-101996-01-02Acuson CorporationImaging system display processor
US5579768A (en)*1995-03-211996-12-03Acuson CorporationAutomatic gain compensation in an ultrasound imaging system
US5617862A (en)*1995-05-021997-04-08Acuson CorporationMethod and apparatus for beamformer system with variable aperture
US5579770A (en)*1995-05-021996-12-03Acuson CorporationMultiple transmit zone splicing
US5601086A (en)*1995-05-121997-02-11The United States Of America As Represented By The Administrator Of The National Aeronautics And Space AdministrationBeat frequency ultrasonic microsphere contrast agent detection system
US5560364A (en)*1995-05-121996-10-01The Board Of Regents Of The University Of NebraskaSuspended ultra-sound induced microbubble cavitation imaging
US5628322A (en)*1995-05-151997-05-13Kabushiki Kaisha ToshibaMethod of ultrasound imaging and diagnostic ultrasound system
US5558092A (en)*1995-06-061996-09-24Imarx Pharmaceutical Corp.Methods and apparatus for performing diagnostic and therapeutic ultrasound simultaneously
EP0770352A1 (en)*1995-10-101997-05-02Advanced Technology Laboratories, Inc.Ultrasonic diagnostic imaging with contrast agents
US5577505A (en)*1996-02-061996-11-26Hewlett-Packard CompanyMeans for increasing sensitivity in non-linear ultrasound imaging systems
US5632277A (en)*1996-06-281997-05-27Siemens Medical Systems, Inc.Ultrasound imaging system employing phase inversion subtraction to enhance the image
US5678554A (en)*1996-07-021997-10-21Acuson CorporationUltrasound transducer for multiple focusing and method for manufacture thereof

Non-Patent Citations (45)

* Cited by examiner, † Cited by third party
Title
"Simulated Capillary Blood Flow Measurement Using a Nonlinear Ultrasonic Contrast Agent," B. Schrope et al., Ultrasonic Imaging 14, pp. 134-158 (1992).
"Synthesis of the driving functions of an array for propagating localized wave energy," J.E. Hernandez et al., J. Acoust. Soc. Am. 92(1), Jul. 1992, pp. 550-562.
1980 IEEE Ultrasonics Symposium, pp. 757 762.*
1980 IEEE Ultrasonics Symposium, pp. 757-762.
Abstracts Journal of the American Society of Echocardiography, vol. 8, No. 3 pp. 345 346, 355, 358 364.*
Abstracts Journal of the American Society of Echocardiography, vol. 8, No. 3 pp. 345-346, 355, 358-364.
B. Schrope, et al., Simulated Capillary Blood Flow Measurement Using a Nonlinear Ultrasonic Contrast Agent. Ultrasonic Imaging 14 (1992).*
Deborah J. Rubens, MD, et al., Sonoelasticity Imaging of Prostate Cancer: In Vitro Results. Radiology, vol. 195, No. 2, 1995.*
excerpt from Ultrasonics: Fundamentals and Applications (1992), pp. 380 393, 363 365.*
excerpt from Ultrasonics: Fundamentals and Applications (1992), pp. 380-393, 363-365.
Fred Lee, Jr., MD, et al., Sonoelasticity Imaging: Results in in Vitro Tissue Specimens. Radiology, vol. 181, No. 1 (1991).*
Frequency Synthesis by Phase Lock; William F. Egan, Ph.D., Senior Engineering Specialist GTE Products Corporation; Lecturer in Electrical Engineering University of Santa Clara, Robert E. Krieger Publishing Company, Malabar, Florida 1990; pp. 14 29.*
Frequency Synthesis by Phase Lock; William F. Egan, Ph.D., Senior Engineering Specialist GTE Products Corporation; Lecturer in Electrical Engineering University of Santa Clara, Robert E. Krieger Publishing Company, Malabar, Florida 1990; pp. 14-29.
H. Edward Karrer, et al., A Phased Array Acoustic Imaging System for Medical Use. IEEE 1980 Ultrasonics Symposium.*
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 37, No. 5, Sep. 1990, "Ultrasonic Nondiffracting Transducer for Medical Imaging," Jian-Yu Lu et al., pp. 438-447.
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 37, No. 5, Sep. 1990, Ultrasonic Nondiffracting Transducer for Medical Imaging, Jian Yu Lu et al., pp. 438 447.*
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 39, No. 1, Jan. 1992, "Non-diffracting X Waves-Exact Solutions to Free-Space Scalar Wave Equation and Their Finite Aperture Realizations," Jian-yu Lu et al., pp. 19-31.
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 39, No. 1, Jan. 1992, Non diffracting X Waves Exact Solutions to Free Space Scalar Wave Equation and Their Finite Aperture Realizations, Jian yu Lu et al., pp. 19 31.*
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 39, No. 3, May 1992, "Experimental Verification of Nondiffracting X Waves," Jian-yu Lu et al., pp. 441-446.
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 39, No. 3, May 1992, Experimental Verification of Nondiffracting X Waves, Jian yu Lu et al., pp. 441 446.*
J.A. Hossack, et al., Improving Transducer Performance Using Multiple Active Layers. SPIE vol. 1733 (1992).*
John A. Hossack, et al., Improving the Characteristics of a Transducer Using Multiple Piezoelectric Layers. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 40, No. 2, Mar. 1993.*
K.J. Parker, et al., "Tissue Response to Mechanical Vibrations for `Sonoelasticity Imaging`." Ultrasound in Med. and Biol., vol 16, No. 3, (1990).
K.J. Parker, et al., Tissue Response to Mechanical Vibrations for Sonoelasticity Imaging . Ultrasound in Med. and Biol., vol 16, No. 3, (1990).*
Ken Ishihara, et al., New Approach to Noninvasive Manometry Based on Pressure Dependent Resonant Shift of Elastic Microcapsules in Ultrasonic Frequency Characteristics. Japanese J. of Applied Physics, vol. 2 (1988).*
Kevin J. Parker, PhD., et al., Sonoelasticity of Organs: Shear Waves Ring A Bell. J. Ultrasound Med., 11 (1992).*
Marc Gensane, Bubble population measurements with a parametric array. J. Acoustical Society of America, 95(6), Jun. 1994.*
P. Tournois; "Acoustical Imaging Via Coherent Reception of Spatially Coloured Transmissions;" 1980 Ultrasonics Symposium; pp. 747-750.
P. Tournois; Acoustical Imaging Via Coherent Reception of Spatially Coloured Transmissions; 1980 Ultrasonics Symposium; pp. 747 750.*
Properties of Swept FM Waveforms in Medical Ultrasound Imaging; C.R. Cole; 1991 Ultrasonics Symposium, pp. 1243 1248.*
Properties of Swept FM Waveforms in Medical Ultrasound Imaging; C.R. Cole; 1991 Ultrasonics Symposium, pp. 1243-1248.
Robert M. Lerner, et al., "`Sonoelasticity` Images Derived from Ultrasound Signals in Mechanically Vibrated Tissues." Ultrasound in Med. and Biol., vol. 16, No. 3 (1990).
Robert M. Lerner, et al., Sonoelasticity Images Derived from Ultrasound Signals in Mechanically Vibrated Tissues. Ultrasound in Med. and Biol., vol. 16, No. 3 (1990).*
Simulated Capillary Blood Flow Measurement Using a Nonlinear Ultrasonic Contrast Agent, B. Schrope et al., Ultrasonic Imaging 14, pp. 134 158 (1992).*
Small Spheres Lead to Big Ideas. Research News, Science vol. 267, Jan. 20, 1995.*
Stanford Research Systems; Scientific and Engineering Instruments 1994 1995; pp. 171 176.*
Stanford Research Systems; Scientific and Engineering Instruments 1994-1995; pp. 171-176.
Stanford Research Systems; Synthesized Function Generator; Model DS345 30 MHz Function & Arbitrary Waveform Generator; 1994; pp. 8 13.*
Stanford Research Systems; Synthesized Function Generator; Model DS345-30 MHz Function & Arbitrary Waveform Generator; 1994; pp. 8-13.
Synchronous Dynamic Focusing for Ultrasound Imaging; G. Manes, et al., IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 35, No. 1, Jan. 1988; pp. 14 21.*
Synchronous Dynamic Focusing for Ultrasound Imaging; G. Manes, et al., IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 35, No. 1, Jan. 1988; pp. 14-21.
Synthesis of the driving functions of an array for propagating localized wave energy, J.E. Hernandez et al., J. Acoust. Soc. Am. 92(1), Jul. 1992, pp. 550 562.*
V.L. Newhouse, et al., Bubble size measurements using the nonlinear mixing of two frequencies. J. Acoustical Society of America, 75(5), May 1984.*
Volkmar Uhlendorf, et al., Nonlinear Acoustical Response of Coated Microbubbles in Diagnostic Ultrasound. IEEE 1994 Ultrasonics Symposium.*
William Armstrong, M.D., et al., Position Paper on Contrast Echocardiography. American Society of Echocardiography, draft 1, Jun. 6, 1994.*

Cited By (6)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US6108273A (en)*1995-03-022000-08-22Acuson CorporationTransmit beamformer with frequency dependent focus
US20060058677A1 (en)*2002-04-262006-03-16Kazutaka OkadaUltrasonograph
EP1500371A4 (en)*2002-04-262011-07-27Hitachi Medical Corp ULTRASONOGRAPH
US8043220B2 (en)2002-04-262011-10-25Hitachi Medical CorporationUltrasonograph
US20240000422A1 (en)*2012-12-282024-01-04Philips Image Guided Therapy CorporationIntravascular ultrasound imaging apparatus, interface architecture, and method of manufacturing
US12295783B2 (en)*2012-12-282025-05-13Philips Image Guided Therapy CorporationIntravascular ultrasound imaging apparatus, interface architecture, and method of manufacturing

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US5696737A (en)1997-12-09
US5608690A (en)1997-03-04
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US6122222A (en)2000-09-19
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WO1996027152A1 (en)1996-09-06
US6108273A (en)2000-08-22

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