US3906950A - Inhaling device for powdered medicaments - Google Patents

Abstract

An inhaling device for medicinal powders comprising a pump and an inhaler wherein the inhaler has a cavity formed by the interconnection of two compartments for holding a puncturable capsule containing a medicinal powder. Two sliding needles acting against the action of return springs pierce the capsule. In a preferred embodiment, the lower body portion of the inhaler is attached to the pump when in use and may be stored in ''''at rest'''' position when the inhaler is inverted into the pump.

Description

tinited States @ocozza 1 INHALING DEVICE FOR POWDERED MEDICAMENTS [75] lnventor: Salvatore Cocozza, Milan, Italy [73} Assignee: I.S.F. S.p.A., Milan, ltaly [22] Filed: Apr. 2, 1974 [21] Appl. No.: 457,270

[30] Foreign Application Priority Data Apr. 4, 1973 Italy 22576/73 June 22, 1973 Italy; 25698/73 [52] US. Cl. 128/266; 128/206 [51] Int. Cl. A61M 13/00; A61M 15/08 [58] Field of Search 128/266, 206, 208, 194, 128/265 [56] References Cited UNITED STATES PATENTS 2,307,986 l/1943 Bolt et al. 128/266 so ,2 20* y 2,517,482 8/1950 Hall 128/206 2,519,555 8/1950 128/266 2,581,182 l/1952 128/206 2,946,332 7/1960 Sacks 128/266 3507277 4/1970 Altounyan et al 128/208 3,669,113 6/1972 Altounyan et a1. 128/266 Primary Examiner-Aldrich F. Medbery Attorney, Agent, or Firm-Depaoli & OBrien [57] ABSTRACT An inhaling device for medicinal powders comprising a pump and an inhaler wherein the inhaler has a cavity formed by the interconnection of two-compartments for holding a puncturable capsule containing a medici nal powder. Two sliding needles acting against the action of return springs pierce the capsule. In a preferred embodiment, the lower body portion of the inhaler is attached to the pump when in use and may be stored in at rest position when the inhaler is inverted into the pump.

22 Claims, 6 Drawing Figures r L 56o US Patent Sept. 23,1975 Sh6t 1 01 2 3,906,950

US mm Sept. 23,1975 Sheet 2' 0f 2 3,9,%

INHALING DEVICE FOR POWDERED MEDICAMENTS BACKGROUND OF THE INVENTION 1. Field of the Invention The invention relates to an inhaler for the administration of medicinal powders. More particularly, the inhaler relates to a traditional pump and an inhaler body having means for piercing a stored capsule containing medicinal powder.

2. Description of the Prior Art Inhalers are already known utilizing an elastic pump and a needle piercing a capsule which contains a me' dicinal substance; generally their working is not completely satisfactory as a result of rather complicated construction and cumbersome dimensions. In the in haler of the present invention, the above mentioned inconveniences have been practically eliminated, so that the inhaler is easily and quickly constructed and of reduced dimensions.

SUMMARY OF THE INVENTION It is the object of this invention to providean inhaler having simplified construction and reduced dimensions for use in combination with a conventional pump as an inhaling device for supplying medicinal powders to a body cavity.

It is another object to provide an inhaler having means for partial storage within the pump therefor.

It is an additional object to provide an inhaler having a means wheel to facilitate locking engagement with the pump.

It is a further object to provide an inhaler having a plurality of slidable alignment means. I

It is also an object to provide an inhaler having a spring-biased means for penetrating each end of a capsule stored therewithin.

In satisfaction of these objects and in accordance with the spirit of this invention, the inhaler contains a cavity-penetrating element. at one end thereof, through which air-entrained powder is forced out into a body cavity. a central element with an inside cavity for locating a capsule of medicinal powder therewithin. a pair of piercing devices for the endwise perforation of the capsule, and a base element having a polished surface interrupted by a ratchet wheel for connection with the pump. In more detail, the central element ofthe inhaler body is relatively fixed and formed by two components which are connected to each other, for example, by threading, bayonet insertion, and similar techniques. These components define a cavity therewithin, for placement of the capsule, and are slidably attached to a pair of relatively movable elements which hold piercing needles and which telescopically slide inside the two above-mentioned capsule holder components against the action of a pair of return springs.

The base element of the inhaler is so shaped that when the device is not in use, the inhaler body may be inverted into the pump, therby resulting in a noticeable reduction in overall size and a pleasant compact aspect of the whole which is aesthetically and practically favorable.

The inhaling device is adapted for delivering powdered substances in aerated form from a pierced capsule and comprises a pump and an inhaler, the inhaler comprising a relatively fixed central element formed by two connectable components and defining a cavity for reception of the capsule. and a pair of relatively moveable needle holder elements telescopically slidablc within the connectable components against the action of a pair of return springs. The components may be connected by screw means, a bayonet clutch means. or the like. Each of the pair of needle holder elements comprises a capsule-piercing needle. Each of the components is attached to a sleeve having an interior shoulder and each of the pair of needle holder elements has an outwardly disposed shoulder which is capable of reciprocating between a rest position against one of the interior shoulders and a ncedle-piercing position against one of the connectable components. The inhaler also comprises a nose piece and a pump piece and one of the pair of holder elements is locked by friction to the noscpiecc and the other of the pair of needle holder elements may be locked against the piece by mi cro-ribs having saw teeth.

BRIEF DESCRIPTION OF THE DRAWINGS The inhaler which constitutes the present invention is shown in the accompanying drawings of the preferred embodiment in which:

FIG. 1 represents a side elevation of the assembled inhaling device comprising the inhaler inserted in a pump in operative condition.

FIG. 2 is a side elevation similar to FIG. I with the inhaler inverted in the pump to reduce the size of the device while partially stored therewithin.

FIG. 3 is a longitudinal section through the inhaler while in uncompressed condition.

FIG. 4 is a longitudinal section of the inhaler. similar to FIG. 3 but with the inhaler in a compressed condition, while in operative combination with a pump.

FIG. 5 is a cross-section taken alonglines 55 of FIG. 3, and

FIG. 6 is a side elevation of the noseward component of the cavity-forming element.

DESCRIPTION OF THE PREFERRED EMBODIMENT Referring to the drawings. theinhaler 8 of this invention is employed in combination with aconventional pump 100 and comprises acentral storage unit 10 having a central cavity defined bywalls 13 within which a medicinal powder-container capsule 15 is inserted as needed by unscrewing a pair ofcompartments 20, 30. A pair ofstop sleeves 60, 70 are non-slidably attached to theunit 10 and are outside of and in sliding relation to a pair ofneedle holders 40, containing a pair of capsule-puncturingneedles 41, 51. The pair ofstop sleeves 60, is also within and in sliding relation to a pair of end pieces, the nose piece and thepump piece 90, to which theholders 40, 50 are rigidly attached. Theholders 40, 50 are biased away from the central cavity by a pair ofsprings 25, 35.

Coaxially disposed throughout the entire inhaler of this invention are a series of central holes for passage of air which enters the inhaler from the pump throughbase opening 98 andair passage 58, passes through the fourair passages 59 shown in FIG. 5 tocentral hole 32 aroundpump needle 51, enters and passes through thepunctured capsule 15 while entraining medicinal powder therefrom. travels pastnose needle 41 throughcentral hole 22, passes through the fourair passages 49 intoswirl compartment 83, and exits from the inhaler throughdischarge hole 81 innosepiece 80.

The unit is formed by screwably connecting the nose compartment and thebase compartment 30. Thecompartments 20, have coaxially disposedcentral holes 22, 32, annularly disposedspring wells 24, 34 which open away from thecapsule 15, outer cylindrical recesses withsurfaces 23, 33, and connectingscrew threads 29, 39 by means of which thecompartments 20, 30 are connected.Nose return spring 25 is seated within spring well 24, and pump return spring is seated within spring well 34.

Nose needle holder 40 and pump needle holder have somewhat l-l-shaped cross sections and comprise. respectively, annularfixed ends 46, 56 and annularsliding ends 47, 57 which rest against thesprings 25, 35 within thespring wells 24, 34, as shown in FIG. 4. Theholders 40, 50 also comprise fourair passages 49, 59 which are separated by four radially spaced longitudinally disposed ribs, ribs 54 only being identified in FIG. 5. Each set ofribs 44, 54 supports a central portion containing a central needle recess which opens only toward the central cavity. Thebutt 42 ofnose needle 41 and the butt 52 ofpump needle 51 are each rigidly attached within these respective central needle recesses so that therespective needle points 43, 53 are coaxially aligned, centrally disposed within thecentral holes 22, 32, and in puncturing relationship to the ends of thecapsule 15 within the range of compressibility of thesprings 25, 35.

Additionally, theholders 40, 50 respectively comprisecircumannular shoulders 45, 55 which extend outwardly exactly as far as thewalls 23, 33 of the sleeve recesses of eachcompartment 20, 30. Thecircular sides 48, 58 of theshoulders 45, 55, opposite to the cavity for thecapsule 15, function as a stop means in cooperation with thenose sleeve 60 and thepump sleeve 70, respectively, and the outer cylindrical surfaces of theshoulders 45, 55 are in sliding contact with the innercylindrical surfaces 61, 71 of thesleeves 60, 70, thus functioning cooperatively therewith as an alignment means.

The nose andpump sleeve 60, respectively comprise elongated cylindrical portions, havingouter sides 62, 72 andinner sides 61, 71, and inwardly extendinginterior shoulders 65, 75, having respective cavityfacingcircular surfaces 66, 76, innercylindrical surfaces 68, 78, and endward-facingcircular surfaces 67, 77. Thesurfaces 68, 78 function as a sliding alignment means in cooperation with thecylindrical surfaces 46a, 56a of thefixed ends 46, 56 of theneedle holders 40, 50. Theinner side 61, 71 are non-slidably attached to the recessedouter surfaces 23, 33 and function cooperatively with the cylindrical outer surfaces of theshoulders 45, 55 as another sliding alignment means. Nonslidable attachment may be attained by means of suitable adhesive or by circumferential knurlings of the facing surfaces such as theknurlings 26 which are indicated in FIG. 6.

Thenose piece 80 comprises a taperedpenetration portion 82 through which passes thecentral discharge hole 81 therein. askirt portion 84 which extends toward thecavity 15, and a steppedportion 85 therebetween. An annular recess coincides with the inner edge of thestep portion 85 and penetrates longitudinally into thepenetration portion 82. Into this annular recess, thefixed end 46 of thenose needle holder 40 is rigidly attached. as with an adhesive. Theouter surface 62 of thenose sleeve 60 is in sliding engagement with the inner surface of theskirt 84 and functions cooperatively therewith as an alignment means.

The pump piece comprises anouter rim 91, abase 92 having an inwardly projecting circular lip to define thebase opening 98, acircular lug 94 spaced pumpward from the edge of therim 91, andcircumferential serrations 97 along the inner surface of thebase 92 and noseward of its circular lip. Thelug 94 has a circular and arcuately recedingsurface 95, which acts as a storage stop means when the inhaler is in its inverted storage position shown in FIG. 2, and a circular and radially extendingsurface 96 which acts as an operational stop means when the inhaler is inserted into aconventional pump 100, as shown in FIGS. 1, 3, and 4. Theserrations 97, which may be considered as ribbings, corrugations, or knurlings, are matched and engaged by similar serrations in thesurfaces 56a.

Thepump 100 typically has side walls 101, a circulartop edge 102 which engages thesurface 96 when theinhaler 8 is in operative position, and an air-containing interior 104 which should have sufficient depth to accommodate theinhaler 8 from the surface to the tip of thepenetration portion 82 when theinhaler 8 is in stored position partially within thepump 100.

In summary, theinhaler 8 comprises three pairs of slidable alignment means:

I. inner cylindrical surfaces ofskirt 84 and rim 91 in sliding contact with outercylindrical surfaces 62, 72; 2. innercylindrical surfaces 61, 71 in sliding contact with outer cylindrical surfaces of theshoulders 45, 55; and 3. innercylindrical surfaces 68, 78 in sliding contact with outer cylindrical surfaces 46:1, 560. Because of these three pairs of slidable alignment means, theinhaler 8 possesses a high degree of trueness so that binding and wear are minimized.

In FIGS. 1-4, the profile of the cylindrical surface of the lower body portion of theinhaler 8, which is connected by friction with a pump of suitable dimensions and configuration, is polished and uniform and interrupted by thelug 94 where circular lines ofcontact 95 and 96 with the cylindrical surface represent the stop points in locking engagement with thepump 100 when theinhaler 8 is ready to use and when it is in storage position, respectively.

The inhaling device operates as follows:

Initially, theinhaler 8, inverted in the pump 100 (as shown in FIG. 2 is extracted therefrom and connected by friction locking in its upright position to thepump 100.Compartment 20 is then screwed off fromcompartment 30 and thecapsule 15 of powder is inserted therein, after which nosepiece 80 andpumppiece 90 are moved towards one another, i.e., a contraction of the inhaler is caused along arrows AB, which creates two diametrally opposed perforations incapsule 15. Compare FIG. 1 with FIG. 4. Thereafter, it is possible to press thepump 100 to provoke the passage of the powder content of the capsule into a human cavity, such as nasal cavity or other cavities of the human body.

The present invention is not to be limited to the specific embodiment having the scope and advantages described hereinbefore, for various modifications can be made without departing from the spirit of the invention which should he understood asbeihglimited onlyiby the scope of the accompanying"claimst a 1. An inhalingdeyice, for-delivering powderedsubstances in aerated form from a pierced capsule, comprisinga pumpand. an inhaler, said inhalercomprising:

A. a, relatively fixed central element formed by two connectahle components and def ini ng a cavity. for reception of said capsule, and

B. a pair of relatively movcable ncc dleiholde'r ielm ments including piercing means mounted therein, which are: i IN 4 i r H l. telescopically slidable within said'corinectable components against the action of a pair of return springs and in the path of movement of air through said inhaler,

2. disposed in mutually opposed relationship and in straddling relationship to said capsule, and

3. constituting a means for piercing said capsule when said springs are compressed by slidably moving said needle holder elements toward each other.

2. The inhaling device of claim 1 whereinsaid components are connected by screw means.

3. The inhaling device of claim 1 wherein each of said pair of needle holer elements comprises a capsulepiercing needle.

4. The inhaling device of claim 1 wherein each of said components is attached to a sleeve having an interior shoulder and each of said pair of needle holder elements has an outwardly disposed shoulder which is capable of reciprocating between a rest position against one of said interior shoulders and a needle-piercing position against one of said conncctable components.

5. The inhaling device of claim 4 wherein said inhaler comprises a nose piece and a pump piece and one of said pair of said needle holder elements is locked by friction to said nose piece and the other of said pair of needle holder elements is locked against said pump piece by micro-ribs having saw teeth.

6. An inhaler for storing, entraining, and delivering powders in aerated condition, comprising;

A. a central storage unit for said powders,

B. a pair of needle holders including piercing means mounted therein which straddle said unit and are slidably connected thereto,

C. a nose piece which is non-slidably attached to one of said pair of needle holders,

D. a pump piece which is non-slidably attached to the other of said pair of needle holders, and

E. a longitudinally disposed air passage means extending from end to end of said inhaler, through said pump piece, said pair of needle holders, said central storage unit, and said nose piece, said nose piece and said pump piece ecah being longitudinally slidable toward said central storage unit to provide opposed piercing means for the central storage unit, whereby said powders are released.

7. The inhaler of claim 6 wherein said central storage unit comprises a pair of connectable compartments which define and contain. in combination, a cavity thcrewithin for storage of a capsule containing said powder.

8. The inhaler of claim 7 wherein each of said pair of conncctable compartments comprises an annular spring well within which a compression spring is seated.

'9. T he inhaler of claim.8 wherein each of said pair of needle holderscomprises a annular sliding end which is;slidably mounted within one of said annular spring wells andinengagement-with one .Of said springs.

10. The inhaler of claim 9.which further comprises a pair of stop:slceves which straddle said. unit and are non-slidably attached thereto.

11:. The inhaler ofclaim 10 wherein said pair of stop sleeves is in slidably circumferential and alignmentma'intaining relation to said pair of needle holder element's. 1 I

"12.The inhaler of claim 11- wherein each of said pair of stop sleeves has a cylindrical inner wall and said needle holders comprise circumanntilar shoulders which extend outwardly into slidable and alignmentmaintaining relation with said cylindrical inner walls of said stop sleeves.

13. The inhaler of claim 12 wherein each of said pair of needle holders additionally comprises an annular fixed end, one of said fixed ends being non-slidably attached to said nose piece and the other being nonslidably attached to said pump piece.

14. The inhaler ofclaim 13 wherein each of said pair of needle holders comprises a capsule-piercing needle, said needles being coaxially disposed in mutually opposed relationship and in straddling relationship to said capsule and being adapted to pierce said capsule when said springs are compressed by slidably moving said nose piece and said pump piece toward each other.

15. The inhaler of claim 14 wherein each of said stop sleeves additionally comprises an inwardly extending interior shoulder which extends into sliding engagement with exterior cylindrical surfaces of said fixed ends, as a sliding alignment means.

16. The inhaler ofclaim 15 wherein:

A. said nosepiece, said stop sleeves, and said central storage unit have a smaller exterior diameter than the exterior diameter of said pump piece, and

B. said pump piece comprises a circumferential and outwardly extending lug having an arcuately recedingsurface and a radially receding surface,

whereby said arcuately receding surface functions as a storage stop means, when said inhaler is inverted into a pump for storage by inserting said nose piece thereinto, and said radially receding surface functions as an operational stop means, when said inhaler is inserted into said pump by engaging said pump piece therewith.

17. The inhaler of claim 16 wherein said pump piece further has an exterior cylindrical surface which is polished and uniformly interrupted by a friction locking means for the mouthpiece of said pump.

18. The inhaling device of claim 17 wherein the points of contact between the cylindrical surface of the lower body portion and the surface normal to said means are friction locking points between said inhaler and said pump.

19. The inhaling device of claim 17 wherein the points of contact between the cylindrical surface of the lower body portion and the portions of said means have curved surfaces which are stop points for friction locking between said inhaler and said pump when said inhaling device is not in use.

20. The inhaling device ofclaim 5 wherein:

A. said nose piece and said. pump piece each comprises a skirt portion extending toward said cavity and having an inner cylindrical surface adapted for sliding contact; and

B. each said sleeve comprises an outer cylindrical surface adapted for said sliding contact with one of said inner cylindrical surfaces of said skirt portions of said nose piece and said pump piece to form a first pair of slidable alignment means.

21. The inhaling device of claim wherein:

Apeach said sleeve, attached to one of said two conncctahle components. comprises an inner cylindrical surface adapted for sliding contact; and

B. each said outwardly disposed shoulder of said pair of needle holder elements comprises an outer cylindrical surface adapted for said sliding contact with one of said sleeves to form a second pair of slidable alignment means.

22. The inhaling device of claim 21 wherein:

A. each said interior shoulder of said sleeves attached to said two components comprises an inner cylindrical surface adapted for sliding contact: and

Bi each said needle holder element comprises an outer cylindrical surface adapted for said sliding contact with one of said inner cylindrical surfaces of said interior shoulders to form a third slidable alignment means. said first, second. and third pairs of slidable alignment means imparting a high degree of trueness to said inhaler so that binding and wear are minimized.

Claims (24)

1. An inhaling device, for delivering powdered substances in aerated form from a pierced capsule, comprising a pump and an inhaler, said inhaler comprising: A. a relatively fixed central element formed by two connectable components and defining a cavity for reception of said capsule, and B. a pair of relatively moveable needle holder elements including piercing means mounted therein, which are: 1. telescopically slidable within said connectable components against the action of a pair of return springs and in the path of movement of air through said inhaler, 2. disposed in mutually opposed relationship and in straddling relationship to said capsule, and 3. constituting a means for piercing said capsule when said springs are compressed by slidably moving said needle holder elements toward each other.

2. disposed in mutually opposed relationship and in straddling relationship to said capsule, and

2. The inhaling device of claim 1 wherein said components are connected by screw means.

3. constituting a means for piercing said capsule when said springs are compressed by slidably moving said needle holder elements toward each other.

3. The inhaling device of claim 1 wherein each of said pair of needle holer elements comprises a capsule-piercing needle.

4. The inhaling device of claim 1 wherein each of said components is attached to a sleeve having an interior shoulder and each of said pair of needle holder elements has an outwardly disposed shoulder which is capable of reciprocating between a rest position against one of said interior shoulders and a needle-piercing position against one of said connectable components.

5. The inhaling device of claim 4 wherein said inhaler comprises a nose piece and a pump piece and one of said pair of said needle holder elements is locked by friction to said nose piece and the other of said pair of needle holder elements is locked against said pump piece by micro-ribs having saw teeth.

6. An inhaler for storing, entraining, and delivering powders in aerated condition, comprising; A. a central storage unit for said powders, B. a apir of needle holders including piercing means mounted therein which straddle said unit and are slidably connected thereto, C. a nose piece which is non-slidably attached to one of said pair of needle holders, D. a pump piece which is non-slidably attached to the other of said pair of needle holders, and E. a longitudinally disposed air passage means extending from end to end of said inhaler, through said pump piece, said pair of needle holders, said central storage unit, and said nose piece, said nose piece and said pump piece ecah being longitudinally slidable toward said central storage unit to provide opposed piercing means for the central storage unit, whereby said powders are released.

7. The inhaler of claim 6 wherein said central storage unit comprises a pair of connectable compartments which define and contain, in combination, a cavity therewithin for storage of a capsule containing said powder.

8. The inhaler of claim 7 wherein each of said pair of connectable compartments comprises an annular spring well within which a compression spring is seated.

9. The inhaler of claim 8 wherein each of said pair of needle holders comprises a annular sliding end which is slidably mounted within one of said annular spring wells and in engagement with one of said springs.

10. The inhaler of claim 9 which further comprises a pair of stop sleeves which straddle said unit and are non-slidably attached thereto.

11. The inhaler of claim 10 wherein said pair of stop sleeves is in slidably circumferential and alignment-maintaining relation to said pair of needle holder elements.

12. The inhaler of claim 11 wherein each of said pair of stop sleeves has a cylindrical inner wall and said needle holders comprise circumannular shoulders which extend outwardly into slidable and alignment-maintaining relation with said cylindrical inner walls of said stop sleeves.

13. The inhaler of claim 12 wherein each of said pair of needle holders additionally comprises an annular fixed end, one of said fixed ends being non-slidably attached to said nose piece and the other being non-slidably attached to said pump piece.

14. The inhaler of claim 13 wherein each of said pair of needle holders comprises a capsule-piercing needle, said needles being coaxially disposed in mutually opposed relationship and in straddling relationship to said capsule and being adapted to pierce said capsule when said springs are compressed by slidably moving said nose piece and said pump piece toward each other.

15. The inhaler of claim 14 wherein each of said stop sleeves additionally comprises an inwardly extending interior shoulder which extends into sliding engagement with exterior cylindrical surfaces of said fixed ends, as a sliding alignment means.

16. The inhaler of claim 15 wherein: A. said nosepiece, said stop sleeves, and said central storage unit have a smaller exterior diameter than the exterior diameter of said pump piece, and B. said pump piece comprises a circumferential and outwardly extending lug having an arcuately receding surface and a radially receding surface, whereby said arcuately receding surface functions as a storage stop means, when said inhaler is inverted into a pump for storage by inserting said nose piece thereinto, and said radially receding surface functions as an operational stop means, when said inhaler is inserted into said pump by engaging said pump piece therewith.

17. The inhaler of claim 16 wherein said pump piece further has an exterior cylindrical surface which is polished and uniformly interrupted by a friction locking means for the mouthpiece of said pump.

18. The inhaling device of claim 17 wherein the points of contacT between the cylindrical surface of the lower body portion and the surface normal to said means are friction locking points between said inhaler and said pump.

19. The inhaling device of claim 17 wherein the points of contact between the cylindrical surface of the lower body portion and the portions of said means have curved surfaces which are stop points for friction locking between said inhaler and said pump when said inhaling device is not in use.

20. The inhaling device of claim 5 wherein: A. said nose piece and said pump piece each comprises a skirt portion extending toward said cavity and having an inner cylindrical surface adapted for sliding contact; and B. each said sleeve comprises an outer cylindrical surface adapted for said sliding contact with one of said inner cylindrical surfaces of said skirt portions of said nose piece and said pump piece to form a first pair of slidable alignment means.

21. The inhaling device of claim 20 wherein: A. each said sleeve, attached to one of said two connectable components, comprises an inner cylindrical surface adapted for sliding contact; and B. each said outwardly disposed shoulder of said pair of needle holder elements comprises an outer cylindrical surface adapted for said sliding contact with one of said sleeves to form a second pair of slidable alignment means.

22. The inhaling device of claim 21 wherein: A. each said interior shoulder of said sleeves attached to said two components comprises an inner cylindrical surface adapted for sliding contact; and B. each said needle holder element comprises an outer cylindrical surface adapted for said sliding contact with one of said inner cylindrical surfaces of said interior shoulders to form a third slidable alignment means, said first, second, and third pairs of slidable alignment means imparting a high degree of trueness to said inhaler so that binding and wear are minimized.

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