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US3897789A - Acupuncture apparatus - Google Patents

Acupuncture apparatus
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US3897789A
US3897789AUS396699AUS39669973AUS3897789AUS 3897789 AUS3897789 AUS 3897789AUS 396699 AUS396699 AUS 396699AUS 39669973 AUS39669973 AUS 39669973AUS 3897789 AUS3897789 AUS 3897789A
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needle
current
impedance
acupuncture
pulses
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Stanley J Blanchard
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Abstract

Pulses of current are supplied to an acupuncture needle by a pulse generator whose pulse-width, frequency and amplitude are adjustably controlled, the pulse source having such high impedance as to cause essentially the desired or adjusted current to flow irrespective of the electrical impedance of the body between the acupuncture needle and another electrode applied to the body, i.e., an adjustable nominally infinte-impedance pulse source. A common pulse generator of adjustable frequency, pulsewidth and intensity is used for providing drive for separate output circuits to energize plural acupuncture needles, respectively.

Description

United States Patent [191 Blanchard ACUPUNCTURE APPARATUS [76] Inventor: Stanley J. Blanchard, 4 Washington Square, New York, N.Y, 10012 22 Filed: Sept. 13, 1973 21 Appl. No.: 396,699
OTHER PUBLICATIONS Capperauld et al., Acupunc. Anesthesia in China," The Lancet, Nov. 25, 1972, pp. 1136-1137. Brown, Use of Acupunc. in Major Surgery, The
[451 Aug. s, 1975 Lancet, June 17, 1972, pp. 1328-1330.
Matsumoto, Acupunc. and US. Medicine," JAMA, May 15, 1972,Vo1. 220, No.7, p. 1010.
Chisolm, Acupunc. Analgesia, The Lancet, Sept, 9, 1972, p. 540.
Primary Examiner-Richard A. Gaudet Assistant E.\'aminer-Lee S. Cohen Attorney, Agent, or Firm-Paul S. Martin [57] ABSTRACT Pulses of current are supplied to an acupuncture needle by a pulse generator whose pulse'width, frequency and amplitude are adjustably controlled, the pulse source having such high impedance as to cause essentially the desired or adjusted current to flow irrespective of the electrical impedance of the body between the acupuncture needle and another electrode applied to the body, i.e., an adjustable nominally infinteimpedance pulse source. A common pulse generator of adjustable frequency, pulse-width and intensity is used for providing drive for separate output circuits to energize plural acupuncture needles, respectively.
4 Claims, 2 Drawing Figures 6m 40.x y/prxr #01:: 6:41.
a ONE-JHdf Mk i Aways/r) 2.9) 0 4 7 mwswJ/ry I Ava/041v? I f X I mmswrimcse- 2- ZZZ I 224 2/ ZZ 225 4 ACUPUNCTURE APPARATUS The present invention relates to apparatus for use in acupuncture therapy and anaesthesiology.
BACKGROUND OF THE INVENTION Acupuncture represents a time-honored technique for treating various ailments, both for curing certain ailments and for easing or erasing pain. More recently acupuncture has been found highly effective in anaesthesiology. In the practice of acupuncture, the acupuncturist inserts one or more fine needles into the patient at locations found by experience to be effective for treating each condition. These locations are called acupuncture points. The needle is fine, perhaps 0.005 inch or less in thickness, having a round, triangular or other cross-section, and ranging in length from about one-half inch to 6 inches. During and after insertion, the acupuncturist vibrates the needle according to the empirically established technique.
Electrical impulses have also been used in acupuncture, as an alternative to manual vibration. Voltage spikes of various frequencies and amplitude have been used, but with limited success.
SUMMARY OF THE INVENTION Pursuant to the present invention, acupuncture apparatus includes what may be called constant-current or infinite-impedance means for electrically energizing the acupuncture needle(s). The body impedance may vary over a wide range, but the pulse source for the needle, or for each needle, has such a high impedance that the resulting current of each pulse is affected only secondarily by variations in electrical impedance of the patients body. Essentially, it is the adjustment of the apparatus that determines the current flow. A further feature is in controlling the duration of the pulses, square-wave pulses in the illustrative apparatus, in contrast to the simple spikes used heretofore.
The nature of the invention including the foregoing and other features will be better appreciated from the following detailed description of an illustrative embodiment shown in the accompanying drawings. In the drawings:
FIG. 1 is a block diagram of illustrative acupuncture apparatus incorporating features of the invention; and
FIG. 2 is a detailed circuit diagram of the apparatus of FIG. 1, modified to energize plural acupuncture needles.
GENERAL An acupuncture needle may be energized by applying electrical pulses between the needle and another electrode attached to the body, either an area contact or another needle. Since the human body acts as a volume conductor, current flows from one needle to 21 reference electrode (a needle or other electrode) via a rather broad front. The body impedance is quite complex, but may be approximated by a resistance R, in series with a capacitance C,, the two shunted by another resistance R,,. At the frequency range here involved, the series-equivalent resistance R, and the reactance of capacitance C, are approximately equal and they vary inversely with the frequency. Resistance R accounts for the finite d-c resistance related to the electrolytic process that takes place at the electrodeelectrolyte interface. This is a non-linear resistance which is a function of the nature of the tissue in contact with the nee dle electrode. For example, perspiration greatly affects the resistance of skin.
There is one of these electrode-body interface impedances R C R for each needle. In addition, the stimulating current may be altered by an equivalent bioelectric voltage and an associated bioelectric equivalent impedance, which represents the body tissue itself between two electrodes.
By making the source of pulses between the electrodes in the form of a source of current pulses, the current level and the corresponding degree of stimulation can be accurately controlled and will not be affected by or dependent on the particular level of body impedance among different patients or at various acupuncture points of a patient. As an absolute concept, a currentpulse source should have infinite impedance. A practical value ofimpedance of a current-pulse source herein is only required to be so high in relation to maximum body impedance that various body impedances that may be encountered will not notably affect the resulting current.
As extreme values, body impedance may be anything in the range of l,000 to 100,000 ohms between an acupuncture needle and another electrode, which may be another needle or an area contact to the skin that is prepared for good conduction. Thus, a 1.0 megohm source impedance would produce prescribed levels of current stimulation within 10% regardless of body impedance. The 10% figure and the impedance variations of 1,000 to 100,000 ohms are extreme figures, so that a 1.0-megohm source impedance is perhaps higher than is absolutely required, but it represents the order of magnitude of the source impedance required.
In the illustrative apparatus in the drawing, the collector of a base-driven transistor is used to provide this impedance. Typically, the collector impedance is greater than 1.0 megohm. With an appropriate emitter resistor it may be at least 1.0 megohm at the maximumcurrent part of the operating characteristic and with an emitter resistor of about 1,000 ohms. Where a low current level of stimulation is desired, a 100,000-ohm emitter resistor may be used. The resulting output impedance at lowand high-current settings is:
where 2 is the collector resistance, 1.0 to 20 meg; B is the current gain of the transistor, typically 50 to I00; and R, is the emitter resistor, being 1,000 ohms to 100,000 ohms in an illustrative example. Accordingly:
2,, 2 meg. 50 100,000 7 meg for a lowcurrent setting, and 2 l meg. I00 1,000 1.1 meg for a highcurrent setting. In all settings, the impedance remains greater than the 1.0 megohm level above.
DETAILED DESCRIPTION Referring now to the drawings, FIG. 1 shows acu puncture apparatus including a constant-current source of pulses 10 for oppositely energizing a metal acupuncture needle 12 inserted into a patient's body and another electrode 14 shown as an area contact to the patients skin (using a conductive gel, if desired) but which may be another needle. Source 10 is nominally a constant-current source, in that its impedance is not infinite in practice but is merely a high order of impedance compared to the maximum body resistance between electrodes 12 and M. The pulses here are unipolar squarewaves and they are of adjustable frequency, duration (pulsewidth) and intensity.
An adjustable-frequency pulse generator 16, e.g., an astable multi-vibrator with a manual frequency control 16adrives pulse generator 18 having a manually adjustable pulse-width control 18a, e.g. a one-shot multivibrator. The output is fed to an intensity adjuster 20, e.g., a potentiometer 200 having a manual control 20b. Intensity indicator 23 measures the pulse intensity. This is converted into current pulses by current-pulse generator 22. This advantageously takes the form of a basedriventransistor 22a having an emitter resistor and adirect connection 226 from the collector to needle 12. Direct-current supply 24 is connected between resistor 22b and electrode 14. This supply also energizes parts l6, l8 and 20 of pulse source 10.
D-C supply 24 is ideally battery-operated so as to enable the apparatus to be free of connection to a power circuit which could expose the patient to shock hazard. Moreover, because usual economical sizes of batteries have inadequate voltage for the presently desired maximum pulse intensity,d-c supply 24 advantageously includes an interrupter or inverter, a step-up transformer and a rectifier and smoothing filter, this being a conventional d-c to d-c step-up converter.
Portions of the pulse source of FIG. 1 are shown in greater detail in FIG. 2, adapted to energize plural acupuncture needles separately. Potentiometer a is connected to the base ofoutput transistor 22a and to the base oftransistor 26 which forms part of intensity indicator 23, shown as a peak-reading detector. The pulses appearing across emitter-follower resistor 28 are rectified bydiode 30 and stored incapacitor 32, and measured by a voltmeter circuit.
The emitter oftransistor 22a is selectively connected by selector switch 36 to one of three current-range selecting resistors 22b-l, 22b-2 or 22b-3 which may for example be 1,000 ohms, l0,000 ohms and l00,000 ohms, respectively. These values typically impart an internal impedance of from 1.] megohms to 7 megohms as shown above.
Collector connection 220 is provided for one needle, to be connected to terminal I. A second transistor 220' also has a base-drive connection topotentiometer 20a, and a separate collector connection 22c toterminal 2 for a separate needle; and it has a corresponding cluster of emitter resistors 22b.Additional terminals 3 to N have respective current-pulse generators. Electrode 14 is to be connected to line 38 which is connected to the negative terminal ofD-C supply 24, the rest of the circuit being energized by the positive terminal of the D-C supply.
The circuit described is advantageously energized by a 60-volt D-C supply, being a relatively safe voltage even in case of component failure. The pulses may be 0.5 to milliseconds long, with a repetition rate that may be adjusted as desired, from zero to I00 pulses per second and another range from 100 to 2,000 pulses per second.
The reading ofindicator 34 provides a direct measurement of the output ofpotentiometer 22a. However, this is proportional to the resulting current levels of needles connected toterminals 1, 2, etc., where the corresponding emitter resistors 22b are selected in the related output circuits.
The foregoing represents an exemplary embodiment for achieving the purposes of the invention. However, it is readily susceptible of variation in details and proportions within the skill of the art, and consequently the invention should be construed in accordance with its full spirit and scope.
What is claimed is:
1. Acupuncture apparatus including multiple metal electrodes at least one of which is a needle of about five thousandths of an inch thick and about one-half inch to 6 inches in length for insertion into a patients body at an acupuncture point and electrical energizing means for oppositely energizing said needle and another of said electrodes, said electrical energizing means including means for providing pulses to the needle in the frequency range between a value approaching zero and 2,000 pulses per second, and said energizing means having impedance means for regulating the current supplied to said needle having a minimum impedance of about 1 megohm at the pulse frequency, whereby the needle is supplied with essentially constant current which is affected only secondarily by varied bodyimpedances of patients.
2. Acupuncture apparatus in accordance with claim I, wherein said pulses are unipolar.
3. Acupuncture apparatus in accordance with claim 1, including plural needles and wherein separate impedance means is included in said energizing means for regulating the current pulses as aforesaid to each of said plural needles.
4. Acupuncture apparatus in accordance with claim 1, further including means for adjusting the impedance means selectively to values ranging from a minimum of about one megohm as aforesaid to many megohms, whereby the needle current is subject to deliberate variation by the user of the apparatus with no more than secondary modification of the current due to varied body-impedances of patients.

Claims (4)

1. Acupuncture apparatus including multiple metal electrodes at least one of which is a needle of about five thousandths of an inch thick and about one-half inch to 6 inches in length for insertion into a patient''s body at an acupuncture point and electrical energizing means for oppositely energizing said needle and another of said electrodes, said electrical energizing means including means for providing pulses to the needle in the frequency range between a value approaching zero and 2,000 pulses per second, and said energizing means having impedance means for regulating the current supplied to said needle having a minimum impedance of about 1 megohm at the pulse frequency, whereby the needle is supplied with essentially constant current which is affected only secondarily by varied body-impedances of patients.
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Cited By (57)

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US4014347A (en)*1975-05-271977-03-29Staodynamics, Inc.Transcutaneous nerve stimulator device and method
US4062365A (en)*1975-06-051977-12-13Kameny Stanley LApparatus for generating applied electrical stimuli signals
FR2359616A1 (en)*1976-07-271978-02-24Pellin HenriSensor probe for measuring resistance of skin - has transistor operating as intermittent switch to avoid continuous feed to electrodes and risk of burning
US4174706A (en)*1977-06-271979-11-20Bernard JankelsonMandible stimulator
US4237896A (en)*1979-08-011980-12-09Senil Nominees Pty. LtdImmobilizing animals
US4372315A (en)*1980-07-031983-02-08Hair Free CentersImpedance sensing epilator
FR2524325A1 (en)*1982-04-021983-10-07Simonin Philippe SKIN PROCESSING METHOD AND DEVICE COMPRISING THE APPLICATION OF SAID METHOD
US4408617A (en)*1980-01-211983-10-11Deloffre AugusteApparatus for detecting the acupuncture points on a patient and for applying electrical stimulating signals to the detected points
US4453548A (en)*1981-06-081984-06-12Empi, Inc.Method of improving sensory tolerance with modulated nerve stimulator
USRE31866E (en)*1979-08-011985-04-16Senil Nominees Pty. Ltd.Immobilizing animals
US4541432A (en)*1982-12-081985-09-17Neurotronic LteeElectric nerve stimulator device
US4556064A (en)*1983-01-251985-12-03Bruce PomeranzElectrotherapy acupuncture apparatus and method
US4558703A (en)*1982-05-271985-12-17Hermann MarkVestibular stimulation method
FR2567762A1 (en)*1984-07-201986-01-24Simonin Philippe DEVICE FOR THE AESTHETIC TREATMENT OF SKIN
EP0177661A1 (en)*1984-10-101986-04-16Hermann Dr. MarkApparatus for vestibule excitation
US4690146A (en)*1985-06-171987-09-01Chattanooga CorporationNeuromuscular stimulating apparatus
US4940060A (en)*1986-09-091990-07-10Hansen GuApparatus for detecting bioelectric signals
US4989604A (en)*1985-10-031991-02-05Accu Science CorporationElectromagnetic device
US5054486A (en)*1990-05-311991-10-08Mamoru YamadaRemedial techniques for the treatment of painful disorders such as intervertebral disc hernia and the like
US5425752A (en)*1991-11-251995-06-20Vu'nguyen; Dung D.Method of direct electrical myostimulation using acupuncture needles
US5957862A (en)*1997-12-011999-09-28Lu; Cheng-LiangAcupuncture device system and methods thereof
WO2004084988A1 (en)2003-03-282004-10-07Lorenz Biotech S.P.A.Electrostimulating system
EP1524009A1 (en)*2003-10-162005-04-20Ela MedicalActive implantable medical device comprising means for ajusting the maximal frequency of ventrical stimulation according to the hemodynamic state of the patient
US7162303B2 (en)2002-04-082007-01-09Ardian, Inc.Renal nerve stimulation method and apparatus for treatment of patients
USRE40279E1 (en)1997-06-262008-04-29Sherwood Services AgMethod and system for neural tissue modification
US7617005B2 (en)2002-04-082009-11-10Ardian, Inc.Methods and apparatus for thermally-induced renal neuromodulation
US7620451B2 (en)2005-12-292009-11-17Ardian, Inc.Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach
USRE41045E1 (en)1996-06-272009-12-15Covidien AgMethod and apparatus for altering neural tissue function
US7653438B2 (en)2002-04-082010-01-26Ardian, Inc.Methods and apparatus for renal neuromodulation
US7853333B2 (en)2002-04-082010-12-14Ardian, Inc.Methods and apparatus for multi-vessel renal neuromodulation
US7937143B2 (en)2004-11-022011-05-03Ardian, Inc.Methods and apparatus for inducing controlled renal neuromodulation
US20110143648A1 (en)*2005-01-062011-06-16Oy Halton Group Ltd.Automatic displacement ventilation system with heating mode
US8131371B2 (en)2002-04-082012-03-06Ardian, Inc.Methods and apparatus for monopolar renal neuromodulation
US8145316B2 (en)2002-04-082012-03-27Ardian, Inc.Methods and apparatus for renal neuromodulation
US8145317B2 (en)2002-04-082012-03-27Ardian, Inc.Methods for renal neuromodulation
US8150520B2 (en)2002-04-082012-04-03Ardian, Inc.Methods for catheter-based renal denervation
US8150519B2 (en)2002-04-082012-04-03Ardian, Inc.Methods and apparatus for bilateral renal neuromodulation
US8347891B2 (en)2002-04-082013-01-08Medtronic Ardian Luxembourg S.A.R.L.Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
US8620423B2 (en)2002-04-082013-12-31Medtronic Ardian Luxembourg S.A.R.L.Methods for thermal modulation of nerves contributing to renal function
US8626300B2 (en)2002-04-082014-01-07Medtronic Ardian Luxembourg S.A.R.L.Methods and apparatus for thermally-induced renal neuromodulation
US8771252B2 (en)2002-04-082014-07-08Medtronic Ardian Luxembourg S.A.R.L.Methods and devices for renal nerve blocking
US8774922B2 (en)2002-04-082014-07-08Medtronic Ardian Luxembourg S.A.R.L.Catheter apparatuses having expandable balloons for renal neuromodulation and associated systems and methods
US8774913B2 (en)2002-04-082014-07-08Medtronic Ardian Luxembourg S.A.R.L.Methods and apparatus for intravasculary-induced neuromodulation
US8818514B2 (en)2002-04-082014-08-26Medtronic Ardian Luxembourg S.A.R.L.Methods for intravascularly-induced neuromodulation
US9192715B2 (en)2002-04-082015-11-24Medtronic Ardian Luxembourg S.A.R.L.Methods for renal nerve blocking
US9308043B2 (en)2002-04-082016-04-12Medtronic Ardian Luxembourg S.A.R.L.Methods for monopolar renal neuromodulation
US9308044B2 (en)2002-04-082016-04-12Medtronic Ardian Luxembourg S.A.R.L.Methods for therapeutic renal neuromodulation
US9327122B2 (en)2002-04-082016-05-03Medtronic Ardian Luxembourg S.A.R.L.Methods for catheter-based renal neuromodulation
US9439726B2 (en)2002-04-082016-09-13Medtronic Ardian Luxembourg S.A.R.L.Methods for therapeutic renal neuromodulation
US9980766B1 (en)2014-03-282018-05-29Medtronic Ardian Luxembourg S.A.R.L.Methods and systems for renal neuromodulation
US10080864B2 (en)2012-10-192018-09-25Medtronic Ardian Luxembourg S.A.R.L.Packaging for catheter treatment devices and associated devices, systems, and methods
US10179020B2 (en)2010-10-252019-01-15Medtronic Ardian Luxembourg S.A.R.L.Devices, systems and methods for evaluation and feedback of neuromodulation treatment
US10194979B1 (en)2014-03-282019-02-05Medtronic Ardian Luxembourg S.A.R.L.Methods for catheter-based renal neuromodulation
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US10537385B2 (en)2008-12-312020-01-21Medtronic Ardian Luxembourg S.A.R.L.Intravascular, thermally-induced renal neuromodulation for treatment of polycystic ovary syndrome or infertility
US10874455B2 (en)2012-03-082020-12-29Medtronic Ardian Luxembourg S.A.R.L.Ovarian neuromodulation and associated systems and methods
US11338140B2 (en)2012-03-082022-05-24Medtronic Ardian Luxembourg S.A.R.L.Monitoring of neuromodulation using biomarkers

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Cited By (147)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US4014347A (en)*1975-05-271977-03-29Staodynamics, Inc.Transcutaneous nerve stimulator device and method
US4062365A (en)*1975-06-051977-12-13Kameny Stanley LApparatus for generating applied electrical stimuli signals
FR2359616A1 (en)*1976-07-271978-02-24Pellin HenriSensor probe for measuring resistance of skin - has transistor operating as intermittent switch to avoid continuous feed to electrodes and risk of burning
US4174706A (en)*1977-06-271979-11-20Bernard JankelsonMandible stimulator
USRE31866E (en)*1979-08-011985-04-16Senil Nominees Pty. Ltd.Immobilizing animals
US4237896A (en)*1979-08-011980-12-09Senil Nominees Pty. LtdImmobilizing animals
US4408617A (en)*1980-01-211983-10-11Deloffre AugusteApparatus for detecting the acupuncture points on a patient and for applying electrical stimulating signals to the detected points
US4372315A (en)*1980-07-031983-02-08Hair Free CentersImpedance sensing epilator
US4453548A (en)*1981-06-081984-06-12Empi, Inc.Method of improving sensory tolerance with modulated nerve stimulator
EP0091853A1 (en)*1982-04-021983-10-19Philippe SimoninMethod for skin treatment and apparatus applying this method
US4522210A (en)*1982-04-021985-06-11Philippe SimoninMethod of skin treatment and device for carrying out the said method
FR2524325A1 (en)*1982-04-021983-10-07Simonin Philippe SKIN PROCESSING METHOD AND DEVICE COMPRISING THE APPLICATION OF SAID METHOD
US4558703A (en)*1982-05-271985-12-17Hermann MarkVestibular stimulation method
US4541432A (en)*1982-12-081985-09-17Neurotronic LteeElectric nerve stimulator device
US4556064A (en)*1983-01-251985-12-03Bruce PomeranzElectrotherapy acupuncture apparatus and method
FR2567762A1 (en)*1984-07-201986-01-24Simonin Philippe DEVICE FOR THE AESTHETIC TREATMENT OF SKIN
EP0177661A1 (en)*1984-10-101986-04-16Hermann Dr. MarkApparatus for vestibule excitation
US4690146A (en)*1985-06-171987-09-01Chattanooga CorporationNeuromuscular stimulating apparatus
US4989604A (en)*1985-10-031991-02-05Accu Science CorporationElectromagnetic device
US4940060A (en)*1986-09-091990-07-10Hansen GuApparatus for detecting bioelectric signals
US5054486A (en)*1990-05-311991-10-08Mamoru YamadaRemedial techniques for the treatment of painful disorders such as intervertebral disc hernia and the like
US5425752A (en)*1991-11-251995-06-20Vu'nguyen; Dung D.Method of direct electrical myostimulation using acupuncture needles
USRE41045E1 (en)1996-06-272009-12-15Covidien AgMethod and apparatus for altering neural tissue function
USRE40279E1 (en)1997-06-262008-04-29Sherwood Services AgMethod and system for neural tissue modification
US5957862A (en)*1997-12-011999-09-28Lu; Cheng-LiangAcupuncture device system and methods thereof
US8934978B2 (en)2002-04-082015-01-13Medtronic Ardian Luxembourg S.A.R.L.Methods and apparatus for renal neuromodulation
US9265558B2 (en)2002-04-082016-02-23Medtronic Ardian Luxembourg S.A.R.L.Methods for bilateral renal neuromodulation
US11033328B2 (en)2002-04-082021-06-15Medtronic Ardian Luxembourg S.A.R.L.Methods and apparatus for renal neuromodulation
US10850091B2 (en)2002-04-082020-12-01Medtronic Ardian Luxembourg S.A.R.L.Methods and apparatus for bilateral renal neuromodulation
US7162303B2 (en)2002-04-082007-01-09Ardian, Inc.Renal nerve stimulation method and apparatus for treatment of patients
US10441356B2 (en)2002-04-082019-10-15Medtronic Ardian Luxembourg S.A.R.L.Methods for renal neuromodulation via neuromodulatory agents
US7617005B2 (en)2002-04-082009-11-10Ardian, Inc.Methods and apparatus for thermally-induced renal neuromodulation
US10420606B2 (en)2002-04-082019-09-24Medtronic Ardian Luxembourg S.A.R.L.Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
US10376311B2 (en)2002-04-082019-08-13Medtronic Ardian Luxembourg S.A.R.L.Methods and apparatus for intravascularly-induced neuromodulation
US7647115B2 (en)2002-04-082010-01-12Ardian, Inc.Renal nerve stimulation method and apparatus for treatment of patients
US7653438B2 (en)2002-04-082010-01-26Ardian, Inc.Methods and apparatus for renal neuromodulation
US10376312B2 (en)2002-04-082019-08-13Medtronic Ardian Luxembourg S.A.R.L.Methods and apparatus for monopolar renal neuromodulation
US7717948B2 (en)2002-04-082010-05-18Ardian, Inc.Methods and apparatus for thermally-induced renal neuromodulation
US7853333B2 (en)2002-04-082010-12-14Ardian, Inc.Methods and apparatus for multi-vessel renal neuromodulation
US10376516B2 (en)2002-04-082019-08-13Medtronic Ardian Luxembourg S.A.R.L.Methods and devices for renal nerve blocking
US10293190B2 (en)2002-04-082019-05-21Medtronic Ardian Luxembourg S.A.R.L.Thermally-induced renal neuromodulation and associated systems and methods
US8131371B2 (en)2002-04-082012-03-06Ardian, Inc.Methods and apparatus for monopolar renal neuromodulation
US8131372B2 (en)2002-04-082012-03-06Ardian, Inc.Renal nerve stimulation method for treatment of patients
US8145316B2 (en)2002-04-082012-03-27Ardian, Inc.Methods and apparatus for renal neuromodulation
US8145317B2 (en)2002-04-082012-03-27Ardian, Inc.Methods for renal neuromodulation
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