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US3814297A - Inhalation actuated aerosol device for dispensing a metered quantity of fluid - Google Patents

Inhalation actuated aerosol device for dispensing a metered quantity of fluid
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Publication number
US3814297A
US3814297AUS00306950AUS30695072AUS3814297AUS 3814297 AUS3814297 AUS 3814297AUS 00306950 AUS00306950 AUS 00306950AUS 30695072 AUS30695072 AUS 30695072AUS 3814297 AUS3814297 AUS 3814297A
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stem
strut
duct
head
aerosol
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US00306950A
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W Warren
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Consort Medical Ltd
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Bespak Industries Ltd
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Abstract

A device for dispensing fluid from an aerosol container of the kind having a spray stem or spray head which, when actuated, dispenses fluid from the container, the device comprising a duct having an inlet and an outlet, means to receive the aerosol container with the outlet of the spray stem or head communicating with the duct, a strut engageable with the stem or head so that relative movement of the strut towards the container will press the stem or head inwardly of the aerosol container, and means for disengaging the strut to release the stem or head when the air pressure at the outlet of the duct falls below the air pressure at the inlet of the duct.

Description

United States Patent Warren INHALATION ACTUATED AEROSOL DEVICE FOR DISPENSING A METERED QUANTITY OF FLUID Inventor: William Edward Warren, Cuffley,
England Assignee: Bespak Industries Limited,
Cheshunt, Waltham Cross, England Filed: Nov. 15, 1972 Appl. No.: 306,950
Foreign Application Priority Data Nov. 25, 1971 Great Britain 54852/71 References Cited UNITED STATES PATENTS 7/1969 Thiel 128/173 June 4, 1974 3,565,070 2/1971 Hanson et al 128/208 X Grandi & Kline [57] ABSTRACT A device for dispensing fluid from an aerosol c0ntainer of the kind having a spray stem or spray head which, when actuated, dispenses fluid from the container, the device comprising a duct having an inlet and an outlet, means to receive the aerosol container with the outlet of the spray stem or head communicating with the duct, a strut engageable with the stem or head'so that relative movement of the strut towards the container will press the stem or head inwardly of the aerosol container, and means for disengaging the strut to release the stem or head when the air pressure at the outlet of the duct falls below the air pressure at the inlet of the duct.
6 Claims, '1 Drawing Figure INHALATION ACTUATED AEROSOL DEVICE FOR DISPENSING A METERED QUANTITY OF FLUID BACKGROUND TO THE INVENTION The invention relates to aerosol containers, and more particularly to devices for dispensing fluid from aerosol containers of the kind having a spray stem or spray head which, when actuated, dispenses fluid from the container. Such aerosol containers will be referred to hereinafter as aerosol containers of the kind described.
With aerosol containers of the kind described known as inward-charging, outward-discharging containers pressing the stem or head inwardly of the container charges a metering chamber in the container and when released the stem or head returns under spring pressure, dispensing a metered dose of fluid With aerosol containers of the kind described known as outward-charging, inwardly discharging containers pressing the stem or head inwardly releases a previously metered dose, and release of the stem or head causes the next dose to be metered and stored.
With aerosol containers of the kind described known as continuous spray containers pressing the stem or head inwardly causes continuous emission of fluid until the stem or head is released.
DESCRIPTION OF THE PRIOR ART The use of aerosols for the relief of ailments such as asthma and bronchitis has been known for many years, and dispensing devices have been proposed for use with such aerosols which devices seek to ensure that the user receives a dose ofa drug at the commencement of inhalation at a mouthpiece.
However such devices are specifically for use with one type of aerosol, generally the outward-charging inwardly discharging type.
Apparatus has been devised in which the user must suck at a mouthpiece and then actuate the aerosol, the user not being able to draw any breath until the aerosol is actuated. This is undesirable as many users have difficulty drawing breath even under normal circumstances. a
In other known devices the user first cocks a spring on the device and then draws a breath through the device. The spring is triggered by a breath controlled valve and the energy stored in the spring is utilised to actuate the aerosol. In other devices a toggle arrangement prevents actuation of the aerosol until suction applied by the user breaks the toggle. However these devices are complicated in construction and therefore expensive. Furthermore as considerable fo'rce is required to actuate the outward-charging, inwardly discharging aerosol the dose is not always released right at the start of drawing breath.
SUMMARY OF THE INVENTION It is an object of the invention to provide a device for dispensing fluid from an aerosol container'which de vice is of very simple and inexpensive construction, being composed of only a small number of moving parts.
It is a further object of the invention to provide such a device in which a dose of fluid may readily be provided when suction is applied to the device.
In general terms these objects are achieved by utilising the fact that inward-charging outward-discharging containers require a very low force to maintain the spray head or stem in the inward position after charging, and hence a very low force to release the dose. This permits the use of a very simple release mechanism.
Accordingly the invention provides a device for dispensing fluid from an aerosol container of the kind described, the device comprising a duct having an inlet and an outlet, means to receive the aerosol container with the outlet of the spray stem or head communicating with the duct, a strut engageable with the stem or head and manually operable to press the stem or head inwardly of the aerosol container, and means for disengaging the strut to release the stem or head when the air pressure at the outlet of the duct falls below the air pressure at the inlet of the duct.
The device according to the invention is very suitable for use with an aerosol container containing medicament for asthma sufferers. If the user manually moves the container and the strut toward one another and then sucks at the duct outlet he will receive medicament at or immediately after commencement of sucking.
The device is particularly suitable for use with an inward-charging, outward-discharging container, as mentioned above, since the force required to hold the head or stem in the inward position, and hence the force required to disengage the strut, is relatively small. It is however a significant advantage of the device that it may be arranged for use with outward charging, inward-discharging or continuous spray containers while still utilising a very simple construction of few parts. In order to ensure that a single discrete dose is emitted at or immediately after commencement of sucking, the strut, or means associated therewith, may be arranged to seal the outlet of the stem or head while the strut is in the engaged position.
The air pressure difference whereby the strut is disengaged may be detected by a pressure responsive device, which may be a vane in the duct. Alternatively, the pressure difference may be detected by a device responsive to air flow in the duct resulting from said pressure difference. Such a flow responsive device may comprise a hot-wire anemometer.
DESCRIPTION OF A SPECIFIC EMBODIMENT One specific example of the invention will now be described with reference to the accompanying drawing which shows a device for dispensing asthma medicament from an aerosol.
Referring to the drawing, aplastics casing 51 has anoutlet orifice 52 suitable for placing in the mouth of a user. Thecasing 51 defines arecess 53 in which there is placed an aerosoltype medicament dispenser 54. Thedispenser 54 has a stem orspray head 55 with anoutlet orifice 56 in one side.Pressing stem 55 inwardly of the aerosol container causes a metering chamber (not shown) to be primed, and release of the stem allows a metered dose of medicament to issue fromori fice 56.
In the device shown in the drawing, apress button 57 has astrut 58 integral therewith but pivotable about a flexible hinge. The strut engages the end of thestem 55, so that when the press button is pushed inward then the stem is pressed into thedispenser 54 and the metering chamber is filled with medicament. Attached to thestrut 58 is alever arm 59, and this in turn is engaged by avane 61 pivoted to the body of the device at ahinge 62. Thevane 61 in its normal position as shown in the drawing blocks a duct within thecasing 51 and extending between anair inlet 63 and theoutlet orifice 52. However, when suction is applied at theoutlet orifice 52 then the difference in air pressure across thevane 61 causes it to move in an anti-clockwise direction thereby opening the passage between theair inlet 63 and theoutlet 52, and at the same time striking thelever arm 59 and causing both the lever arm and also thestrut 58 to rotate in a clockwise direction about the hinge joint between the strut and thepress button 57.
It will be clear that, if before this occurs thepress button 57 has been pressed inwardly to hold thestem 55 into thedispenser 54, then the above-described sequence of events will release the stem and sprayhead 55 so that it will move downwardly and the dose of medicament stored within the valve will be dispensed into the air stream flowing out oftheorifice 52. It will be appreciated that in use of the device the asthma sufferer presses the push-button 57 upwardly and holds it and then draws breath through theoutlet orifice 52; the arrangement ensures that the medicament is dispensed at the beginning of the inhalation thereby assuring maximum effect. I
So as to ensure that the device resets itself after use, thestrut 58 is provided with anextension 64 engageable with a spring loadedpin 65. When the device is operated the rotation of thelever arm 59 and thestrut 58 by thevane 61 depresses thepin 65, but when thepress button 57 is thereafter released the pin tilts the strut back towards thestem 55 to engage it.
The embodiment described is suitable for use with any reservoir of the appropriate size and having a metering valve which is primed on the inward stroke of the stem and dispenses medicament on the outward stroke. One particular form of such a metering valve utilizes a hollow stem as the receptacle, and is charged by pressing the stem and sprayhead 55 inwardly past a stem seal until theorifice 56 is within the reservoir, whereupon medicament under pressure enters the hollow stem through the orifice, and subsequent release of the stem andspray head 55 dispenses the medicament. This is, however, only one of several possible valve constructions. In some constructions theoutlet orifice 56 is in the end ofthe stem, not the side. The device of this example may be adapted for use with an outwardcharging, inward-discharging container, or a continuous spray container, by providing means which sea] the outlet orifice when the strut is in the engaged position shown. Thus pressing the strut inwardly will cause a dose of medicament to be stored in the spray stem, removal of the strut allowing the dose to escape through the outlet orifice of the stem.
Other modifications and improvements may be made without departing from the invention, as will be appreciated by those skilled in the art.
The sealing means may for example comprise a sealing pad on the strut, or a piston carrying a sealing pad and interposed between the strut and the spray stem.
If desiredbutton 57 may be dispensed with, the relative movement of the strut towards the container being brought about by manual downward movement of the container.
I claim:
1. An aerosol device comprising an aerosol container of the type which has a tubular valve stem and which on depression of the stem measures out a metered quantity of fluid ready for discharge through the stem when the stem is released, a duct which is in fluid con nection with the tubular valve stemand has one end open to atmosphere and the other end arranged for insertion into the mouth of a user, a two-part strut having a first part to engage the stem and a second part which is manually engageable to move the strut between an inoperative position in which the stem is released and an operative position in which the stem is depressed, a flow sensor in the duct, and means to move the first part of the strut out of engagement with the stem to release the stem when the flow sensor detects a flow of air in the duct when a user inhales through the duct, the arrangement being such that release of manual pressure from the second part of the strut will also release the stem.
2. A device as claimed in claim 1 in which the flow sensor comprises a vane in the duct sensitive to a pressure differential between the outlet and the inlet of the duct.
3. A device as claimed in claim 1 in which the first part of the strut carries a projection which is engageable by the vane to move the said first part out of engagement with the stem.
4. A device as claimed in claim 1 in which the parts of the strut are pivotally connected together.
5. A device as claimed in claim 4 in which the two parts of the strut are spring biased into the position where the first part is engageable with the stem.
6. A device as claimed in claim 4 in which the two parts of the strut are integrally formed from plastics material.

Claims (6)

1. An aerosol device comprising an aerosol container of the type which has a tubular valve stem and which on depression of the stem measures out a metered quantity of fluid ready for discharge through the stem when the stem is released, a duct which is in fluid connection with the tubular valve stem and has one end open to atmosphere and the other end arranged for insertion into the mouth of a user, a two-part strut having a first part to engage the stem and a second part which is manually engageable to move the strut between an inoperative position in which the stem is released and an operative position in which the stem is depressed, a flow sensor in the duct, and means to move the first part of the strut out of engagement with the stem to release the stem when the flow sensor detects a flow of air in the duct when a user inhales through the duct, the arrangement being such that release of manual pressure from the second part of the strut will also release the stem.
US00306950A1971-11-251972-11-15Inhalation actuated aerosol device for dispensing a metered quantity of fluidExpired - LifetimeUS3814297A (en)

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GB5485271AGB1413285A (en)1971-11-251971-11-25Aerosol devices

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JP (1)JPS4860314A (en)
CA (1)CA990249A (en)
DE (1)DE2257759A1 (en)
FR (1)FR2163048A5 (en)
GB (1)GB1413285A (en)
IE (1)IE36835B1 (en)
IT (1)IT973697B (en)
NL (1)NL7215858A (en)
ZA (1)ZA728006B (en)

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US4291688A (en)*1979-01-111981-09-29Schering Corp.Inhalation device
US4576157A (en)*1983-10-241986-03-18Raghuprasad Puthalath KOral inhalation apparatus
US4664107A (en)*1983-10-281987-05-12Minnesota Mining And Manufacturing CompanyInhalation activatable dispensers
US4803978A (en)*1985-08-091989-02-14Johnson Iv John JApparatus for actuating an inhaler
US4819834A (en)*1986-09-091989-04-11Minnesota Mining And Manufacturing CompanyApparatus and methods for delivering a predetermined amount of a pressurized fluid
US4852561A (en)*1988-07-271989-08-01Sperry C RInhalation device
US5027808A (en)*1990-10-311991-07-02Tenax CorporationBreath-activated inhalation device
US5031610A (en)*1987-05-121991-07-16Glaxo Inc.Inhalation device
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US5119806A (en)*1987-05-121992-06-09Glaxo Inc.Inhalation device
US5217004A (en)*1990-12-131993-06-08Tenax CorporationInhalation actuated dispensing apparatus
US5224472A (en)*1990-02-091993-07-06Solange QuenderffInhalation device
US5232124A (en)*1992-03-101993-08-03Advanced Monobloc CorporationPressure relief device and method
WO1994011044A2 (en)1992-11-121994-05-26Minnesota Mining And Manufacturing CompanyPowder inhaler
US5347998A (en)*1990-07-091994-09-20Minnesota Mining And Manufacturing CompanyBreath actuated inhaler having an electromechanical priming mechanism
US5392768A (en)*1991-03-051995-02-28AradigmMethod and apparatus for releasing a controlled amount of aerosol medication over a selectable time interval
US5394866A (en)*1991-03-051995-03-07Aradigm CorporationAutomatic aerosol medication delivery system and methods
US5404871A (en)*1991-03-051995-04-11AradigmDelivery of aerosol medications for inspiration
US5450336A (en)*1991-03-051995-09-12Aradigm CorporationMethod for correcting the drift offset of a transducer
US5497764A (en)*1991-03-051996-03-12Aradigm CorporationMedication cassette for an automatic aerosol medication delivery
US5497763A (en)*1993-05-211996-03-12Aradigm CorporationDisposable package for intrapulmonary delivery of aerosolized formulations
US5509404A (en)*1994-07-111996-04-23Aradigm CorporationIntrapulmonary drug delivery within therapeutically relevant inspiratory flow/volume values
US5511540A (en)*1992-08-181996-04-30Minnesota Mining And Manufacturing CompanyInhalation device
US5709202A (en)*1993-05-211998-01-20Aradigm CorporationIntrapulmonary delivery of aerosolized formulations
US6012454A (en)*1989-04-282000-01-11Minnesota Mining And Manufacturing CompanyDry powder inhalation device
US6029661A (en)*1991-08-262000-02-293M Innovative Properties CompanyPowder dispenser
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WO2002088317A2 (en)2001-05-012002-11-07The Regents Of The University Of CaliforniaFusion molecules and methods for treatment of immune diseases
US6581804B1 (en)*2002-01-112003-06-24Joseph S. KanferHolder for aerosol dispenser
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US20040020486A1 (en)*2000-03-182004-02-05Huxham Laurence StanmoreInhaler
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Cited By (86)

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US3935999A (en)*1973-12-191976-02-03Colgate-Palmolive CompanySpray confining aerosol device
US4291688A (en)*1979-01-111981-09-29Schering Corp.Inhalation device
US4576157A (en)*1983-10-241986-03-18Raghuprasad Puthalath KOral inhalation apparatus
US4664107A (en)*1983-10-281987-05-12Minnesota Mining And Manufacturing CompanyInhalation activatable dispensers
US4803978A (en)*1985-08-091989-02-14Johnson Iv John JApparatus for actuating an inhaler
US4819834A (en)*1986-09-091989-04-11Minnesota Mining And Manufacturing CompanyApparatus and methods for delivering a predetermined amount of a pressurized fluid
US5031610A (en)*1987-05-121991-07-16Glaxo Inc.Inhalation device
US5119806A (en)*1987-05-121992-06-09Glaxo Inc.Inhalation device
US4852561A (en)*1988-07-271989-08-01Sperry C RInhalation device
US6012454A (en)*1989-04-282000-01-11Minnesota Mining And Manufacturing CompanyDry powder inhalation device
US5069204A (en)*1989-08-231991-12-03Riker Laboratories, Inc.Inhaler
US5224472A (en)*1990-02-091993-07-06Solange QuenderffInhalation device
US5347998A (en)*1990-07-091994-09-20Minnesota Mining And Manufacturing CompanyBreath actuated inhaler having an electromechanical priming mechanism
US5060643A (en)*1990-08-071991-10-29Tenax CorporationBreath-activated inhalation device
US5027808A (en)*1990-10-311991-07-02Tenax CorporationBreath-activated inhalation device
US5217004A (en)*1990-12-131993-06-08Tenax CorporationInhalation actuated dispensing apparatus
US5743252A (en)*1991-03-051998-04-28Aradigm CorporationMethod for releasing controlled amount of aerosol medication
US5520166A (en)*1991-03-051996-05-28Aradigm CorporationMedication cassette for an automatic aerosol medication delivery system
US5394866A (en)*1991-03-051995-03-07Aradigm CorporationAutomatic aerosol medication delivery system and methods
US5404871A (en)*1991-03-051995-04-11AradigmDelivery of aerosol medications for inspiration
US5450336A (en)*1991-03-051995-09-12Aradigm CorporationMethod for correcting the drift offset of a transducer
US5497764A (en)*1991-03-051996-03-12Aradigm CorporationMedication cassette for an automatic aerosol medication delivery
US5826570A (en)*1991-03-051998-10-27Aradigm CorporationDelivery of aerosol medications for inspiration
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US5608647A (en)*1991-03-051997-03-04Aradigm CorporationMethod for releasing controlled amount of aerosol medication
US6029661A (en)*1991-08-262000-02-293M Innovative Properties CompanyPowder dispenser
US6119688A (en)*1991-08-262000-09-193M Innovative Properties CompanyPowder dispenser
US5232124A (en)*1992-03-101993-08-03Advanced Monobloc CorporationPressure relief device and method
US5511540A (en)*1992-08-181996-04-30Minnesota Mining And Manufacturing CompanyInhalation device
WO1994011044A2 (en)1992-11-121994-05-26Minnesota Mining And Manufacturing CompanyPowder inhaler
US5709202A (en)*1993-05-211998-01-20Aradigm CorporationIntrapulmonary delivery of aerosolized formulations
US5823178A (en)*1993-05-211998-10-20Aradigm CorporationDisposable package for use in aerosolized delivery of drugs
US5718222A (en)*1993-05-211998-02-17Aradigm CorporationDisposable package for use in aerosolized delivery of drugs
US6014969A (en)*1993-05-212000-01-18Aradigm CorporationDisposable package for use in aerosolized delivery of antibiotics
US5544646A (en)*1993-05-211996-08-13Aradigm CorporationSystems for the intrapulmonary delivery of aerosolized aqueous formulations
US5497763A (en)*1993-05-211996-03-12Aradigm CorporationDisposable package for intrapulmonary delivery of aerosolized formulations
EP1366778A2 (en)1993-05-212003-12-03Aradigm CorporationSystems for the intrapulmonary delivery of aerosolized aqueous formulations
EP1310268A2 (en)1994-07-112003-05-14Aradigm CorporationIntrapulmonary drug delivery within therapeutically relevant inspiratory flow/volume values
US5509404A (en)*1994-07-111996-04-23Aradigm CorporationIntrapulmonary drug delivery within therapeutically relevant inspiratory flow/volume values
US8584668B2 (en)1997-11-142013-11-19Astrazeneca AbInhalation device
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US6325062B1 (en)1998-06-182001-12-04Clavius Devices, Inc.Breath-activated metered-dose inhaler
US6415784B1 (en)*1998-09-242002-07-09Astrazeneca AbInhaler
US6460537B1 (en)*1998-11-162002-10-083M Innovative Properties CompanyBreath-actuated aerosol dispensers
WO2000029054A1 (en)1998-11-162000-05-253M Innovative Properties CompanyBreath-actuated aerosol dispensers
US6354290B1 (en)*1998-12-112002-03-12Bespak PlcInhalation apparatus
US20040241800A1 (en)*1999-05-202004-12-02Jue Rodney AlanVascular endothelial growth factor dimers
US20030096754A1 (en)*1999-05-202003-05-22Pollitt N. StephenVascular endothelial growth factor variants
US6475796B1 (en)1999-05-202002-11-05Scios, Inc.Vascular endothelial growth factor variants
US6887848B2 (en)1999-05-202005-05-03Scios, Inc.Vascular endothelial growth factor variants
US20050119165A1 (en)*1999-05-202005-06-02Scios, Inc.Vascular endothelial growth factor dimers
US20050158394A1 (en)*2000-02-282005-07-21Vectura LimitedDelivery of oral drugs
EP1941868A2 (en)2000-02-282008-07-09PharmaKodex LimitedImprovements in or relating to the delivery of oral drugs
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Also Published As

Publication numberPublication date
IT973697B (en)1974-06-10
DE2257759A1 (en)1973-05-30
IE36835B1 (en)1977-03-02
JPS4860314A (en)1973-08-24
NL7215858A (en)1973-05-29
ZA728006B (en)1974-06-26
GB1413285A (en)1975-11-12
AU4896872A (en)1974-05-16
IE36835L (en)1973-05-25
CA990249A (en)1976-06-01
FR2163048A5 (en)1973-07-20

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