US3785773A - Chemical analysis tube module - Google Patents

Abstract

An integral, thin wall thermoplastic chemical analysis tube module has a plurality of test tubular receptacles disposed normally to an elongated rectangular planar area and has a surrounding first wall frame segment of uniform height secured to and supportively disposed around a perimeter major segment of the planar area. A first uniform stiffener lip is integrally secured to and disposed around the first frame segment opposite the planar area. An opposed pair of second wall frame segments having a second uniform height is secured to and supportively oppositely disposed around a pair of opposed perimeter minor segments of the planar area. The second wall height is precisely greater than the first wall height. A pair of second uniform stiffener lips is secured to and disposed around the second frame segment perimeter, also opposed to the planar area. The temporary compressive displacement of the second pair of stiffener lips inside the perimeter of the first pair of stiffener lips provides an expansive precise jaw clamp on release of the clamp, which can secure the tube module combination in a configured cut out aperture in a supporting plate.

Description

United States Patent 1 Rohrbau'gh Jan. 15, 11974 CHEMICAL ANALYSIS TUBE MODULE [57] ABSTRACT [75] Inventor: 2 Rohrbaugh Santa An integral, thin wall thermoplastic chemical analysis a l tube module has a plurality of test tubular receptacles [73] Assignee; Beckman Instruments, Eng, disposed normally to an elongated rectangular planar Fullerton, Calif. area and has a surrounding first wall frame segment of Filed Mar 2 1972 uniform height secured to and supportively disposed [52] US.Cl 23/253 R, 23/259, 23/292 [51] Int. Cl G0ln 1/10, GOln 1/14, GOln 1/18 [58] Field ofSearch 23/259, 253, 292

' [56] References Cited UNITED STATES PATENTS 3,487,862 1/1970 'Soderblom 23/259 X 3,532,470 10/1970 Rochte i 23/253 3,540,856 11/1970 Rochte et a1. 23/253 X 3,713,771 1/1973 Taylor et al. 23/259X 3,713,985 1/1973 'Astle 23/253 X Primary Examiner-Morris O. Wolk Assistant ExaminerR. E. Serwin Att0rneyThomas L. Peterson et a1.

around a perimeter major segment of the planar area.

A first uniform stiffener lip is integrally secured to and disposed around the first frame segment opposite the planar area. An opposed pair of second wall frame segments having a second uniform height is secured to and supportively oppositely disposed around a pair of opposed perimeter minor segments of the planar area. The second wall height is precisely greater than the first wall height. A pair of second uniform stiffener lips is secured to and disposed around the second frame segment perimeter, also opposed to the planar area. The temporary compressive displacement of the second pair of stiffener lips inside the perimeter of the first pair of stiffener lips provides an expansive precise jaw clamp on release of the clamp, which can secure aperture in a supporting plate.

8 Claims, 6 Drawing Figures CHEMICAL ANALYSIS TUBE MODULE CROSS-REFERENCES TO RELATED APPLICATIONS This application is related to the following applications, all assigned to the same assignee as the present application:

Ser. No. 177,555 for TABLET DISRUPTOR DE- VICE by Donald B. Rohrbaugh and Everett Petersen, Jr., filed Sept. 18, 1971; and the following applications filed herewith,

Ser. No. 231,348 for CHEMICAL SAMPLE REAC- TOR MODULE by Donald G. Rohrbaugh;

Ser. No. 231,268 for CHEMICAL ANALYSIS SAM- PLE DISSOLVER MODULE by Donald G. Rohrbaugh, Everett Petersen, Jr., and C. P. Chase;

Ser. No. 231,353 for CHEMICAL ANALYSIS RO- TARY MODULE by Donald G, Rohrbaugh and William R."Pearson; and

Ser. No. 231,351 for AUTOMATED CHEMICAL ANALYSER SYSTEM by Donald G. Rohrbaugh, William R. Pearson, Everett Petersen, Jr., and C. P. Chase.

BACKGROUND OF THE INVENTION The chemical analysis tube module of this invention is particularly useful in automated chemical analysis requiring wet chemical analysis of substances dissolved in solution. It is very desirable to have a simple, relatively inexpensive, chemically clean test tubular module in which a set of wet chemical analysis procedures can be conducted. After one or more analyses of a specific composition the module may be discarded, if desirable.

A sample capsule and filtering mechanism relating to the present invention is disclosed in US. Pat. No. 3,540,856 to J. E. Rochte and Jack L. Hoffa. A sample capsule has a cup of special form in which a precipitate is formed and a filter cup with a filter paper bottom is received atop the precipitate. A mechanism is provided for automatically dropping the filter cup into the capsule and applying a vacuum to the cup, drawing clear filtrate through the filter paper into the cup for further processing.

Unger in US Pat No. 3,533,744 discloses an automated apparatus and method, particularly adapted to patient blood sample analysis.

Baruch and Travaglio in US. Pat No. 3,192,968 disclose an apparatus for performing analytical procedures, treating liquid samples in accordance with predetermined analytical methods. v

In Canadian Pat. No. 868,484 Rochte, Martin, Hoffa, and Moore also teach an automated chemical analyzer, utilizing the sample capsule and filtering mechanism of Rochte et a] referenced above.

SUMMARY OF THE INVENTION An integral thin wall thermoplastic chemical analysis tube module combination provides a plurality of test tubular receptacles which is quickly positioned and locked in place in an automated chemical analysis device. The tube module provides means in which the wet chemical analysis of a sample solution can be sucessively carried out in a plurality of tubular receptacles. A volume of liquid sample and the required volumes of reagent solutions can be transferred from one test tubular receptacle to another as required, prior to a final automated analysis measurement by spectro-photometer or the like. The integral tube module combination has an elongated rectangular planar area having a plurality of uniform aperture test tubular receptacles normally disposed to and integrally secured to the planar area. The tubular receptacles are symmetrically disposed along the elongated line of symmetry of the planar area. A first wall frame segment, having a first uniform height, is integrally secured to and supportively disposed around a major fractional segment of the perimeterof the planar area. A first uniform stiffener lip is secured to and disposed around a perimeter of the first frame segment, opposed to the planar area. An opposed pair of second thin wall frame segments, each one having a second uniform height, is secured to and supportively oppositely disposed around a pair of minor fractional segment perimeters of said planar area. The second wall height is precisely greater than the first wall height. A pair of second uniform stiffener lips is secured to and disposed around the pair of second frame segment perimeters opposed to the planar area. All of the above components are integrally joined and provide a flexible hinge displacement of the opposed pair of second frame segments with respect to the first frame segments, on the application of compressive force to the pair of second segments. The hinge displacement is adapted to an unclamping and clamping movement of the pair of second lips in a configured cut out aperture in a supporting plate. The lip height difference between the first and second stiffener lips provides a precise jaw clamp, securing the module combination in the configured cut out aperture.

Other aspects and advantages of this invention are taught in the following description and claims.

BRIEF DESCRIPTION OF THE DRAWINGS The description of this invention is to be read in conjunction with the following drawings:

FIG. I is a perspective elevational view of the chemical analysis tube module of this invention illustrating the plural test tubular receptacles and the precise jaw clamp provided by the hinge displacement of the first and second stiffener lips.

FIG. 2 is a plan view showing the elongated rectangular planar area having a plurality of test tubular receptacles disposed in andv secured to the planar area, symmetrically along the elongated line of symmetry of the area.

FIG. 3 is a sectional view through 3-3 of FIG. 1.

FIG. 4 is a plan view of a cover plate which can be indexed coplanarly over the planar area illustrated in FIG. 2.

FIG. 5 is a cross sectional view through 55 of FIG. 4.

FIG. 6 is a planar view of a supporting plate in an automated chemical analyser, wherein the chemical analysis tube module is shown disposed in an operative configuration in the analyser table, together with a configured cut out aperture in the supporting table into which the tube module fits.

DESCRIPTION OF THE PREFERRED EMBODIMENT Referring to FIGS. 1, 2 and 3 in detail, the chemicalanalysis tube module 10 is first shown in a perspective view, having an elongated rectangular thinwall planar area 11. Thearea 11 has a plurality of uniform aperture testtubular receptacles 12 normally disposed to and integrally secured to thearea 11. Theuniform aperture diameter 13 has a typical line ofcenter 14 for thereceptacle 12. The elongated line ofsymmetry 15 of theplanar area 11 bisects the plurality ofreceptacles 12. The receptacles are disposedthespaced distance 28 on the line ofsymmetry 15. A first thinwall frame segment 16 has a first uniform wall height 17, and is integrally secured to and disposed around the major fractional segment perimeter of theplanar area 11. A firstuniform stiffener lip 18 is integrally secured to and disposed around the perimeter of thefirst frame segment 16, opposed to theplanar area 11.

An opposed pair of second thinwall frame segments 19 each have a seconduniform wall height 23 integrally secured to and supportively oppositely disposed around a pair of minor fractional segment perimeters of theplanar area 11. The first thinwall frame segments 16 and the second thinwall frame segments 19 are integrally secured together and to the planar area 1 l. Typically the firstuniform stiffener lip 18 is disposed the major fractional perimeter of thetube module 10 over thelength 21, excepting for the minor fractional perimeters of the pair of opposed second thinwall frame segments 19. Over the second thinwall frame segments 19 having thelengths 20, the pair of seconduniform stiffener lips 24 is disposed. The pair oflips 24 is integrally secured to and disposed opposed to theplanar area 11.

As illustrated in FIG. 3, thelip height difference 26 between thestiffener lip 18 and the opposed pair ofstiffener lips 24 provide a precise jaw clamp, useful for securing thetube module combination 10. By utilizing a flexible thermoplastic, thin wall material, the compressive displacement force on the pair ofsegments 19, inwardly displaces the second pair ofstiffener lips 24 to the position of the displacedlips 24.

lieferring now to FIG. 6, th e compressed second Thus each one of a multiplicity oftube module combinations 10 can be placed in a single configured cut outaperture 51 in a rotary indexing table or the like, positioning the tube module for a systematic uniform automated analytical procedure.

FIGS. 2 and 4 taken in conjunction with FIG. 1 illustrates a pair of diagonally opposed indexing meansapertures 35 provided in thecover 30, suitable for indexing thecover 30 with its appropriate pair of indexing pins 29.

Referring to FIGS. 4, 5 and 6 in detail, thecover plate 30 is illustrated, havingplural apertures 31 disposed therein, each one of theapertures 31 being spaced along the elongated line ofsymmetry 36 of thecover 30. The typical spaceddistance 34 between a pair ofapertures 31 provides a confrontingaperture 31 for each one of theuniform aperture diameters 13 oftube module 10. Each one of theapertures 31 hasmultiple sectors 32 formed therein by incising divisions radially directed from the circular center ofapertures 31. Thediameters 33 of theplural apertures 31 are substantially equal to theuniform aperture diameter 13 of the test tubular receptacle 12'.

FIG. 5 indicates in a cross sectional view of FIG. 4 that themultiple sectors 32 are thin films, easily flexed in a hinged manner, as they are attached to the body of thecover 30. Thus in FIG. 6, it is possible to insert a liquid volume sample probe through thecover 30 overtube module 10 inserting a liquid sample or providing a reagent for a chemical reaction. Themultiple sectors 32, when bent downward on insertion of a tubular probe, also provide an important wiping action when the probe is removed, the exterior of the probe being wiped by the flexingsectors 32. Thesectors 32 then return to their normally planar horizontal position after the removal of the probe tube.

FIG. 6 discloses in planar view atube module 10 covered by acover 30. Thecover 30 is secured by the pair of indexing pins 29, 29. Theplural apertures 31 are shown havingmultiple sectors 32 disposed in horizontal planar position. Anindexing land 40, which is a component of thetube module 10 is shown disposed in a position suitable for activating an indexing switch or the like. When the table 50 in which thetube modules 10 are disposed, rotates beneath a pressure activated switch, theindexing land 40 can activate the switch, sending an electrical signal through a desired electrical circuit. Atube module 10 can have anindexing aperture 27 as illustrated in FIG. 2, disposed adjacent theland 40, as an indexing means useful for further precisely locating themodule 10, or the like. Theaperture 27 can be indexed with a locatingpin 52 which can be secured on the table 50, or the like, adjacent the typical cut-out aperture 51.

The specific embodiment of thetube module 10 has five test tubular receptacles. The plurality of test tubular receptacles can typically range from two to seven. Each receptacle can provide an analytically clean volume in which a liquid sample can be disposed and reacted when necessary with reagents to produce a desired chemical step, in an analytical procedure suitable for automated analysis. Typically each single test tube receptacle can range in volume from 2 to 20 millimeters, or the like, depending upon the volume required for analysis.

It is becoming increasingly necessary in terms of the variety and complexity of consumer oriented masses of chemical, pharmaceutical and food products that automated means be provided for analyzing the products in order to safeguard the health and safety of the consumer populace. The invention disclosed herein provides an inventive advance in the art of automated chemical analysis.

Obviously, many modifications and variations in the improvement in a chemical analysis tube module can be made in the light of the above illustrative embodiment, and teaching. It is therefore understood that within the scope of the appended claims, the invention may be practiced otherwise than as specifically described.

I claim:

1. An integral, thin wall thermoplastic chemical analysis tube module combination comprising:

an elongated rectangular, planar area having a plurality of test tubular receptacles of uniform apertures normally disposed to and secured to said planar area, said tubular receptacles disposed along the elongated line of symmetry of said planar area;

a first thin wall frame segment having a first uniform height secured to and supportively disposed around a major fractional segment perimeter of said planar area,

a first uniform stiffener lip secured to and disposed around the perimeter of said first frame segment, opposed to said planar area,

an opposed pair of second wall frame segments, each one having a second uniform height, secured to and supportively oppositely disposed around a pair of minor fractional segment perimeters of said planar area, said first and second thin wall frame segments secured together, and said second wall height precisely greater than said first wall height,

a pair of second uniform stiffener lips secured to and disposed around said pair of second frame segment perimeters opposed to said planar area,

said first frame segment, first lip, pair of second frame segments, pair of second lips providing a flexible hinge displacement of said opposed pair of second frame segments with respect to said first frame segment on application of compressive force to said pair of second segments, said hinge displacement suitable for an unclamping and a clamping movement of said lips in a configured cut out aperture, and

the lip height difference between said first and said second stiffener lips providing a precise jaw clamp, rigidly securing said tube module combination in said configured cut-out aperture in a supporting plate.

2. A chemical analysis tube module as set forth in claim 1 wherein said plurality of test tubular receptacles range from two to seven.

3. A chemical analysis tube module as set forth in claim 1 wherein each test tubular receptacle ranges from a volume of 2 to milliliters.

4}. A chemical analysis tube module as set forth in claim l wherein a signal land area is disposed across said elongated line of symmetry adjacent to and being a minor fractional area of said rectangular planar area.

5. A chemical analysis tube module as set forth in claim 1 wherein a thermoplastic cover plate having indexing means coplanarly securing said cover to said rectangular planar area has a cover aperture disposed over each test tubular receptacle aperture, each said cover aperture formed of a plurality of thin, flexible, radial sector divisions flexibly hinged to the perimeter of said cover aperture.

6. In an integral, thin wall, thermoplastic chemical analysis tube module having an elongated rectangular planar area to which a plurality of test tubular receptacles of uniform apertures are normally secured along the elongated line of symmetry and having a thin wall frame which is supportively disposed around the planar area perimeter, the combination comprising:

a first wall frame segment of uniform height, forming a major fractional segment perimeter of said planar area,

a first uniform stiffener lip integrally secured to and disposed around the perimeter of said first frame segment, opposed to said planar area,

an opposed pair of second wall frame segments, each one having a second uniform height, supportively oppositely disposed around ,a pair of minor fractional segment perimeters of said planar area, said second wall height precisely greater than said first wall height,

a pair of second uniform stiffener lips integrally secured to and disposed around said pair of second frame segment perimeters opposed to said planar area said first frame segment, first lip, pair of second frame segments, and pair of second lips providing a flexible hinge displacement of said opposed pair of second frame segments with respect to said first frame segment on application of compressive force to said pair of second segments, said hinge displacement. suitable for an unclamping and a clamping movement of said lips in a configured cut-out aperture, and

the lip height difference between said first and said second stiffener lips providing a precise jaw clamp, rigidly securing said tube module combination in said configured cut-out aperture in a supporting plate. I

7. A chemical analysis tube module as set forth in claim 6 wherein a signal land area is disposed across said elongated line of symmetry, adjacent to and being a minor fractional area of said rectangular planar area.

8. A chemical analysis tube module as set forth in claim 6 wherein a thermoplastic cover plate having indexing means coplanarly securing said cover to said rectangular planar area has a cover aperture disposed over each test tubular receptacle aperture, each said cover aperture formed of a plurality of thin, flexible, radial sector divisions flexibly hinged to the perimeter of said cover aperture.

Claims (7)

1. 2. A chemical analysis tube module as set forth in claim 1 wherein said plurality of test tubular receptacles range from two to seven.
2. 3. A chemical analysis tube module as set forth in claim 1 wherein each test tubular receptacle ranges from a volume of 2 to 20 milliliters.
3. 4. A chemical analysis tube module as set forth in claim 1 wherein a signal land area is disposed across said elongated line of symmetry adjacent to and being a minor fractional area of said rectangular planar area.
4. 5. A chemical analysis tube module as set forth in claim 1 wherein a thermoplastic cover plate having indexing means coplanarly securing said cover to said rectangular planar area has a cover aperture disposed over each test tubular receptacle aperture, each said cover aperture formed of a plurality of thin, flexible, radial sector divisions flexibly hinged to the perimeter of said cover aperture.
5. 6. In an integral, thin wall, thermoplastic chemical analysis tube module having an elongated rectangular planar area to which a plurality of test tubular receptacles of uniform apertures are normally secured along the elongated line of symmetry and having a thin wall frame which is supportively disposed around the planar area perimeter, the combination comprising: a first wall frame segment of uniform height, forming a major fractional segment perimeter of said planar area, a first uniform stiffener lip integrally secured to and disposed around the perimeter of said first frame segment, opposed to said planar area, an opposed pair of second wall frame segments, each one having a second uniform height, supportively oppositely disposed around a pair of minor fractional segment perimeters of said planar area, said second wall height precisely greater than said first wall height, a pair of second uniform stiffener lips integrally secured to and disposed around said pair of second frame segment perimeters opposed to said planar area, said first frame segment, first lip, pair of second frame segments, and pair of second lips providing a flexible hinge displacement of said opposed pair of second frame segments with respect to said first frame segment on application of compressive force to said pair of second segments, said hinge displacement suitable for an unclamping and a clamping movement of said lips in a configured cut-out aperture, and the lip height difference between said first and said second stiffener lips providing a precise jaw clamp, rigidly securing said tube module combination in said configured cut-out aperture in a supporting plate.
6. 7. A chemical analysis tube module as set forth in claim 6 wherein a signal land area is disposed across said elongated line of symmetry, adjacent to and being a minor fractional area of said rectangular planar area.
7. 8. A chemical analysis tube module as set forth in claim 6 wherein a thermoplastic cover plate having indexing means coplanarly securing said cover to said rectangular planar area has a cover aperture disposed over each test tubular receptacle aperture, each said cover aperture formed of a plurality of thin, flexible, radial sector divisions flexibly hinged to the perimeter of said cover aperture.

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