US3712301A - Gun type hypodermic injector with rapid cartridge displacement within holder - Google Patents

Abstract

A hypodermic injector is provided comprising a sleeve housing a cocked spring impelled plunger, a cartridge holder with a cannula pierceable stopper at the front end thereof attached to the sleeve and a cartridge with front end attached cannula in the holder wherein the rear end only of the cartridge is frictionally retained in the holder and in air tight sealing engagement therewith, the cartridge being otherwise substantially unrestrained from movement with respect to the holder, the free end of the cannula lying within the holder until the plunger is released, all to maintain cannula sterility and yet allow rapid movement of the cartridge in the holder when the plunger is operative.

Description

United States Sarnoff 1 Jan. 23, 1973 [54] GUN TYPE HYPODERMTC INJECTOR WITH RAPID CARTRIDGE DISPLACEMENT WITHIN HOLDER [75] Inventor: Stanley Sarnoff, Bethesda, Md.

[73] Assignee: Survival Technology Inc., Bethesda,

[63] Continuation-in-part of Ser. No. 751,395, Aug. 9, 1968, abandoned, and a continuation of Ser. No. 839,794, June 26, 1969, abandoned.

[52] U.S. Cl ..128/218 A, 128/218 D, 128/218 F [51] Int. Cl. ..A61m 5/20 [58] Field of Search.....l28/2l8 D, 218 DA, 218 NV,

128/218 M, 218 R, 218 F, 272, 218 A [56] References Cited UNITED STATES PATENTS 2/1955 Krug ..128/218 F 2,607,344 8/1952 Brown ....128/218 M UX 2,832,339 4/1958 Sarnoff et a1... ..128/2l8.2

2,894,509 7/1959 Bednarz ..128/218 NV 3,335,914 8/1967 Strazdins et a1 ..128/218 R X FOREIGN PATENTS OR APPLICATIONS 714,983 9/1954 Great Britain ..128/218 D 1,008,915 11/1965 Great Britain ..128/218 R 282,268 12/1964 Netherlands ..128/218 F Primary Examiner-William E. Kamm Assistant Examiner-]. C. McGowan Att0rney-Fred L. Witherspoon, Jr.

[57] ABSTRACT A hypodermic injector is provided comprising a sleeve housing a cocked spring impelled plunger, a cartridge holder with a cannula pierceable stopper at the front end thereof attached to the sleeve and a cartridge with front end attached cannula in the holder wherein the rear end only of the cartridge is frictionally retained in the holder and in air tight sealing engagement therewith, the cartridge being otherwise substantially unrestrained from movement with respect to the holder, the free end of the cannula lying within the holder until the plunger is released, all to maintain cannula sterility and yet allow rapid movement of the cartridge in the holder when the plunger is operative.

13 Claims, 17 Drawing Figures PATENTEDJAH 23 i975 SHEET 3 OF 5 INVENTOR. Sm/VLEY J SHRNOFF' PATENTEDJAH 23 ms SHEET Q [If 5 IN VEN TOR.

5mm E Y J SARNOFF PATENTEfiJAn 23 um SHEET 5 [IF 5 INVENI'OR STANLEY J SHRNOFF GUN TYPE HYPODERMIC INJECTOR WITH RAPID CARTRIDGE DISPLACEMENT WITHIN HOLDER This application is a continuation-in-part of application Ser. No. 751,395, filed Aug. 9, I968, Stanley J. Sarnoff, titled Gun Type Hypodermic Injector With Rapid Cartridge Displacement Within Holder now abandoned, and a continuation of application Ser. No. 839,794, filed June 26, 1969, of the same inventor and title, now abandoned.

The invention relates to hypodermic injection devices of the gun type, i.e., of the type wherein a plunger is cocked against the force of a source of potential energy which plunger when released will exert a force on a piston to expel medication from an ampoule associated with the gun.

The invention relates more specifically to a type of injection device employing such a gun wherein the gun is combined with a cartridge comprising an ampoule having a cannula attached thereto and a holder for the cartridge, the cartridge and holder constituting a cartridge assembly and providing a sterile atmosphere for the cannula. Upon operation of the gun, the cartridge is shifted relative to the holder, driving the cannula out of the holder after which the medication in the ampoule is rapidly expelled via the cannula.

In such injection devices, in the prior art, attempts have been made to attain sterility of the end of the cannula which ultimately extends out of the holder while it was still within said holder, as by maintaining a close fit between the ampoule and its holder. But in doing so the movement of the cartridge relative to the holder, upon gun operation, was necessarily slowed down because of the friction between the ampoule and holder. Also, as a result of the close fit, a mass of air under compression was built up in advance of the moving ampoule as it advanced in the holder, thereby retarding the rapid exposure of the cannula and causing the possible premature expulsion of the medication from the ampoule.

It is an object of this invention to provide a sterile package for use with a gun, the package comprising a cartridge and a holder therefor, with the ampoule of the cartridge initially frictionally held in the holder but freely movable with respect thereto once the frictional engagement has been released by initial operation of the gun.

Another object of the invention is to provide an injection device comprising a gun, and a package as set forth above separably connected together whereby the same gun may be used with successive packages.

It is yet another object of this invention to provide a component type injection device comprising a sleeve, a cartridge assembly fitted into one end of the sleeve and a gun assembly positioned in the other end of the sleeve FIG. 2. is a cross sectional view of the same injection device with the gun released and the contents of the cartridge expelled therefrom;

FIG. 3 is a cross section of the line 3-3 of FIG. 1;

FIG. 4 is a view similar to FIG. 1 illustrating a modified form of the invention;

FIG. 5 is a view similar to FIG. 2 showing the modified form of invention of FIG. 4;

FIG. 6 is a cross sectional view taken on line 6-6 of FIG. 4;

FIG. 7 is a cross sectional view of the preferred form of the injection device with the gun in cocked position;

FIG. 8 is a sectional view of the device of FIG. 7, illustrating the intermediate position of operation wherein the gun has propelled the plunger and engaged cartridge forward and forced the cannula out through the stoppered end;

FIG. 9 is a sectional view of the device of FIG. 7, illustrating the complete travel of the plunger resulting in full discharge of the medicament from the ampoule;

FIG. 10 is a cross sectional view taken along line 10l0 of FIG. 7 showing the manner in which the plunger engages the end periphery of the ampoule;

FIG. 11 is a cross sectional view taken along line 11-11 of FIG. 10 further illustrating the manner in which the plunger engages the end of the ampoule;

FIG. 12 is a cross sectional view taken along line 12-l2 of FIG. 7 showing the relative disposition of parts of the gun assembly;

FIG. 13 is a cross sectional view taken along line l3l3 of FIG. 7 illustrating the inner profile of the safety cap.

FIG. 14 is a cross sectional view of yet another form of the injection device with the gun in cocked position;

FIG. 15 is a sectional view of the device of FIG. 14 lllustrating the complete travel of the plunger resulting in full discharge of the medicament from the ampoule;

FIG. 16 is a cross sectional view taken along line 16-46 of FIG. 14, and

FIG. 17 is a cross sectional view taken along line 17-17 of FIG. 14.

Now referring to the drawings with greater particularity, in FIGS. 1 and 2 there is shown an assembly of a gun indicated generally at 10, acartridge holder 12 and acartridge 14, the cartridge comprising anampoule 16 and acannula 18.

Thegun 10 comprises a structure of the general type shown in the U. S. Pat. to Sarnoff et al. No. 2,832,339 and includes an inner tube orinner sleeve 20 having a threaded end portion 24 and being provided with an integral knurledknob 22 for facilitating rotation of the inner sleeve when assembling this sleeve to the threaded portion 52 ofcartridge holder 12. Theinner sleeve 20 is closed at itsunthreaded end 26 except for acentral opening 28 for the passage therethrough of the furcated end ofplunger 30, the right hand end of which in cooperation with the outer face of theend 26 of thesleeve 20 provides a restraint against the forcing of theplunger 30 out of the inner sleeve by the action of aspring 32 under compression between ashoulder 34 on theplunger 30 and the inner face of theinner sleeve end 26. As explained more fully in the Sarnoff US. Pat. No. 2,832,339, the plunger at its right hand end, as viewed in FIGS. 1 and 2, is furcated and the springy metal of the plunger normally is positioned so thatconical portions 36 have flat faces resting against the outer face ofend 26. When the furcations are compressed together, theconical portions 36 are of a diameter less than the diameter of theopening 28 and the spring is then free to expand and rapidly move the plunger to the left. Anouter sleeve 38 is telescopically movable on the inner sleeve and is provided with a thickenedend 40 having an inner central cam face 42 to engage theconical portions 36 and squeeze them together when the outer sleeve is moved to the left. To prevent inadvertent release of theplunger 30, asafety device 44 is provided, comprising a knurled manuallyengageable cap 46 having anintegral pin 48 insertable between the furcations to prevent collapsing movement of theconical portions 36.

Thecartridge holder 12 shown in FIGS. 1 and 2 comprises a hollow cylindrical shell 50 of resilient material, such as a plastic material, having a threaded end 52 for engagement with the threaded portion 24 of thegun sleeve 20. The shell tapers from the threaded end 52 toward the other end both internally and externally for ease of removal thereof in molding of the shell and is reinforced by outsidelongitudinal ribs 54. At the smaller diametered end of the shell there is provided aconical nose 56 with acentral opening 58, this opening in the unoperated condition of the injection device being closed off by an air and microorganism impervious stopper, such as a puncturable rubber stopper 60. Closely adjacent the threaded end of the shell 50, there is provided abead 62 running completely about the inner wall of the shell. The bead is for the purpose of frictionally engaging and retaining an end portion ofampoule 16 and to form a peripheral seal therewith, thus preventing the entrance of microorganisms into the space occupied by thecannula 18.

Thecartridge 14 is of the general type disclosed in the Sarnoff US. Pat. No. 3,391,695 issued July 9, 1968, and comprises anampoule 16 and acannula 18 attached to the ampoule by ahollow cap 68 firmly embracing asleeve 66 fixed to thecannula 18 and spun over theflange 70 at the neck portion of the ampoule. Within the ampoule a resilient diaphragm 72 is held to theflange 70 by thecap 68, said diaphragm being adapted to be burst by application of fluid pressure to a thinned wall 74 thereof. Within the ampoule at the right hand end thereof is apiston 76 forming space between it and the diaphragm for themedicament 78. When the medicament is forced to the left by operation ofpiston 76, the fluid pressure will invert the V-shaped wall 74 and stretch it so that it eventually bursts either by reason of tension in the membrane or by reason of the stretched membrane engaging a sharp projection in thesleeve 66 or the sharp end of thecannula 18 extending into thesleeve 66. The ampoule is slightly tapered in diameter from the piston end to the cannula end with the external diameter of the ampoule at the piston end portion thereof being slightly greater than the internal diameter of thebead 62 so that when the cartridge is forced into the holder, there is a peripheral hermetic seal between thebead 62 and the exterior wall of theampoule 16. The holder or ampoule or bead must be sufficiently elastic to permit the insertion of the ampoule into the holder without rupturing of parts. Since the front end of the holder is sealed off by the stopper 60, when thecartridge 14 is inserted into theholder 12 while working in a sterile atmosphere, a noncontaminating atmosphere is created and maintained in and about thecannula 18.

The greatest external diameter of theampoule 16 at the piston end is less than the internal diameter of theholder 12 in front of thehead 62 and throughout the entire length of displacement of the ampoule in the holder so that once the ampoule has been freed from thebead 62 there is freedom of motion of the cartridge in the holder. Moreover, there is sufficient clearance between the external diameter of the ampoule l6 and the internal diameter of theholder 12 to permit free movement of gas from in front of the ampoule to the rear thereof on displacement of the cartridge.

In the use of the injector device, first thegun 10 is cocked by forcing theplunger 30 into theinner sleeve 20 until theconical portions 36 pass through theopening 28 and spread out to engage the outer surface of the end 26-of thesleeve 20. For safety reasons, thepin 48 is inserted between the .furcations of the plunger. While in a sterile atmosphere, thecartridge 14 is loaded into theholder 12 with theampoule 16 in air sealing engagement with thebead 62 and thecannula 18 in nonpierced-through relationship with the stopper 60. The utilizer of the injection device threadedly couples theholder 12 to the gun l0 and the device is now ready for use. To use the device, thesafety pin 48 is removed and the stoppered end of theholder 12 is pressed firmly against the desired area of injection. Upon telescopic action ofsleeve 38 onsleeve 20,conical portions 36 pass through opening 28 and theplunger 30 is released. Under the action ofspring 32, the plunger shifts the cartridge so that the end of the cannula l8 pierces the stopper 60 and enters the flesh of the patient. Movement of the cartridge continues until arrested by the nose of the holder. Continued movement of the plunger and movement of thepiston 76 in the ampoule causes an expulsion of the medicament through the cannula into the patient.

In FIGS. 4 to 6 there is disclosed a modified form of the invention. In this species of the invention, thebead 62 in the holder is replaced in part by a plurality of internal ribs and in part by a flanged portion on the ampoule 90. The ribs indicated as 82 are equally spaced around the inner peripheral wall of the holder and run parallel to the longitudinal axis thereof. The number of ribs may be conveniently selected as three. The ribs terminate short of the threadedend 84 of the holder and taper in decreasing height and width as they extend toward the stoppered nose end.

The cartridge utilized with this form of holder is like the cartridge previously described except that the end of the ampoule, here indicated as 90, is modified by placing a flaredportion 92 at the open end thereof, the flared portion being resilient and becoming progressively thinner toward the mouth or right hand end of the ampoule. The external diameter of the ampoule is less than the diameter afforded by the clearance between theribs 82 to allow free movement by the ampoule with respect to the holder, but the flared portion of the ampoule in the unoperated position of parts resiliently engages the inner wall of the holder to the right of the ribs to form a peripheral hermetic seal therewith.

When the injector device of FIGS. 4 to 6 is put into operation, theplunger 30 moves the cartridge to the left, as previously explained. In this operation theflanged portion 92 engages theribs 82 and becomes distorted providing avenues for flow of gaseous fluid therearound to the rear of the ampoule, the fluid flowing along the ribs and through passageways opened by flange distortion.

The preferred form of this invention is illustrated in FIGS. 7-13 of the drawings. In this embodiment the device comprises an outercylindrical sleeve 100 having aninturned shoulder 110 at one end and anannular groove 113 in the inner wall adjacent the other open end. Acartridge assembly 106 is assembled in the shouldered end of theouter sleeve 100. Thecartridge assembly 106 includes acartridge holder sleeve 104 fitted within thesleeve 100 and having a decreasedforward end portion 153 forming ashoulder 154 which fits againstseat 112 provided by outer sleeve shoulder 1 10. The extremeforward end portion 156 of theholder sleeve 104 is tapered to form a small circular opening which is closed by acannula pierceable stopper 150 that hermetically seals this end of thecartridge holder 104.

Thecartridge assembly 106 includes anampoule 136 withliquid medicament 146 therewithin and apiston 148 at one end with acannula 150 at the other end. Within the neck of theampoule 136 between the inner end of thecannula 150 and the medicament there may be interposed a fluid pressurerupturable diaphragm 152 generally like that described in the embodiment of FIG. 1. More specifically, the ampoule and cannula combination may be essentially like that in US. Pat. No. 3,391,695 to Sarnoff.

Referring particularly to FIG. 7, thecartridge assembly 106 is assembled in theouter sleeve 100 with thecannula 150 spaced from the stoppered end of theholder 104. The piston end of theampoule 136 is retained in place within theholder sleeve 104 by resilient contact between the exterior surface of theampoule 136 and anannular bead 160 on the inner wall of theholder sleeve 104 adjacent its open end. Thisbead 160, as in FIG. 1, hermetically seals the ampoule at its piston end and frictionally retains it in position within theholder sleeve 104. The diameter of the exterior of theampoule 136 is less than the internal diameter of of theholder sleeve 104 throughout the major length of said holder sleeve so that once the ampoule is moved forward and is free of theannular bead 160 and thecannula 150 has pierced thestopper 158, the ampoule will move freely in the holder sleeve. The gas in front of the ampoule will readily flow past the ampoule in the annular space between the ampoule and the inner wall of theholder sleeve 104 as the ampoule travels forward. By this method of sealing, thecannula 150 may be maintained in a sterile environment until use is made of the device. It should be noted that the forward interior of theholder sleeve 104 is contoured to form aseat 161 for the forward end of the ampoule, when it is advanced thereinto. The overall length of theampoule 136 andcannula 150 is such that it is all contained within theholder sleeve 104 as illustrated in FIG. 7.

Theouter sleeve 100 is of such length that it accommodates thecartridge assembly 106 in one end and receives thegun assembly 200 in the other to complete the device. Thegun assembly 200 comprises aninner gun sleeve 101 having an out-turnedflange 103 which fits up against the end of thecartridge holder sleeve 104 when the gun assembly is inserted in theouter sleeve 100. The other end of theinner gun sleeve 101 is centrally apertured to form ahole 120. The rear outer face 122 of theinner gun sleeve 101 is planar and perpendicular to the longitudinal axis of the sleeve for a purpose to be brought out later.

Aplunger 162 fits within the out turned flange end of theinner gun sleeve 101. This plunger has acylindrical body portion 163 and acircular head portion 164 of a diameter larger than thebody portion 163 and generally slightly less than that of thepiston 148 in theampoule 136. Thehead 164 has an opening which is sized to align and correspond to the throughhole 166 in theplunger body 163. Theplunger head 164 is provided with a plurality of eircumferentially spaced, radially extendingtabs 168. As best illustrated in FIGS. 10 and 11, these tabs form a diameter greater than that of theplunger head 164 so that the tabs will engage the end of theampoule 136. It should be noted that each tab tapers inwardly from its outer edge to provide aneck portion 170 of thinner proportions.Longitudinal slots 172 are formed in theplunger head 164 immediately behind thetabs 168. These slots are sized so that they will accommodate thetabs 168 when they are later broken off or bent rearwardly at theirneck portion 170 in the operation of the device. These slots extend throughout the length of the head behind the tabs.

Referring to FIGS. 7 and 11, alocking detent 176 is fitted through thehole 166 in theplunger 162 and has acentral body portion 178 with outwardly extendinglugs 180 on one end fitting onannular shoulder 182 of theplunger head 164. The other end of thelocking detent 176 is provided with four equally spaced longitudinally extendingspringy detent arms 184 terminating in frusto-conical detent heads 186. Thislocking detent 176 maintains theplunger 162 andinner gun sleeve 101 in assembled position with acoil spring 138 compressed therebetween as follows. Acoil spring 138 is positioned over theplunger body 163 and abuts theplunger head 164 at one end and the inner face of the end wall of theinner sleeve 101 at the other. Upon compressing of the coil spring 133 sufficiently the detent heads 186 will be cammed inwardly by engaging the periphery of the end wall opening 120 and pass therethrough whereupon the bases of the detent heads 186 will come to rest on the planar face 122 of theinner gun sleeve 101 to retain the plunger and inner gun sleeve in assembled condition with thecoil spring 138 compressed therebetween. When desired the rear planar surface 122 of theinner sleeve 101 may be overlaid with ametal washer 127, in which case it is advantageous to provide a guide and holdingflange 128 to surround theopening 120. Theflange 128 is provided with a lip portion to retain the washer in place.

As best illustrated in FIG. 12, theinner gun sleeve 101 has a plurality of longitudinally extending raisedribs 129 running from theflange 103 approximately one-half the length of the said sleeve. Anouter gun sleeve 192 fits overinner gun sleeve 101 and is sized to frictionally engageribs 129. Theouter sleeve 192 has aclosed end 194 with acentral aperture 196 from which extends a frusto-conical cam surface 198 sized and shaped to cooperate with frusto-conical detent heads 186 to cam said heads radially inwardly. Theouter gun sleeve 192 is provided with acircumferential locking rib 199 which tits ingroove 113 in theouter sleeve 100 to retain thegun assembly 200 in position in said outer sleeve. It should be noted that the length ofouter gun sleeve 192 is slightly less than that of theinner gun sleeve 101 so as to make certain that there will be space between the inner wall of theouter gun sleeve 192 and theflange 103 of theinner gun sleeve 101 so that the two gun sleeves may move relative to each other to cam frusto-conical detent heads 186 inwardly in operating the device.

In order to make certain that the frusto-conical detent heads 186 are not accidentally cammed inwardly, a safety pin assembly is provided. This safety pin assembly comprises acap 142 having acylindrical sleeve 143 sized to fit over the end portion ofouter gun sleeve 192. Asafety pin 144 extends inwardly from the center of thecap 142 into the opening formed by the inner portions of the detent heads 186 to thereby prevent inward movement of said detent heads. Thecap 142 is provided internally with a plurality ofspacer abutments 145 to assure proper positioning of the cap on theouter sleeve 192.

In the use of the form of invention disclosed in FIGS. 7 to 13, the parts are furnished to the user thereof as illustrated in FIG. 7.

For use, initially thesafety pin 144 is removed and then the forward end of the device is applied to the patient at the locus desired. Subsequently, when theouter gun sleeve 192 is thrust toward the locus, a telescoping action takes place between the outer and inner gun sleeves. An advantage of the arrangement of FIGS. 7 to 13 is that theouter sleeve 100 is long and the injection device may be grasped very conveniently along substantially its entire length to operate it.

Telescoping action of the gun sleeves causes the frusto-conical cam surface 198 to cam the detent heads 186 together, whereby they become smaller in diameter than theopening 120, and thespring 138 becomes effective to advance theplunger 162. In the initial movement, theplunger tabs 168 engage the end of theampoule 136 and force it forwardly off thebead 160 and upon further travel forces thecannula 150 throughstopper 158 into the position illustrated in FIG. 8. At this point, theampoule 136 andcannula 150 are fully seated whereby further travel of theplunger 162 causestabs 168 to be sheared off at theneck portion 170 and fall back intoslots 172 so that the plunger may continue to move forward by engaging theampoule piston 148 to force the medicament out of thecannula 150 and ultimately arrive at the position illustrated in FIG. 9 with thepiston 148 pressed against the closed end of the ampoule.

The many advantages of the embodiment of FIGS. 7-13 are immediately apparent, for example, the construction lends itself to component assembly operation. The device may be said to comprise three basic components, namely, theouter sleeve 100, thecartridge assembly 106 and thegun assembly 200. Thecartridge assembly 106 is slipped into theouter sleeve 100 down against shoulder seat 1 12 after which thegun assembly 200 is inserted in theouter sleeve 100 by having the lockingrib 199 engageannular groove 113 in theouter sleeve 100. The device is thus assembled and ready for use.

Yet another embodiment of this invention is shown in FIGS. 14 to 17. In this form of the invention the unit comprises anouter sleeve 400, an innerplunger containing sleeve 402, and acartridge holder 404 with acartridge 406 therein.

The outer sleeve is of springy material, as a molded material, the forward end portion of which is slotted as indicated at 408, FIG. 17, there being, for example, two such diametrical slots. The forward end ofsleeve 400 is further provided with an outwardly extendingflange 410 and is thickened at that end to provide aninternal seat 412 for thecartridge holder 404 as will be described. When thecartridge holder 404 is positioned within theouter sleeve 400, a ring such as analuminum ring 414, is spun around theflange 410 to retain the holder and outer sleeve in assembled relationship. In that condition, theouter sleeve 400 is bowed slightly outwardly away from thecartridge holder 404, as indicated most markedly at 415, so as to permit easy telescopic movements of the parts. The rear right-hand end of theouter sleeve 400 is centrally apertured as indicated at 416 and provided with a bevelled surface interiorly of the sleeve to form acam surface 418. The.

inner sleeve 402 is also centrally apertured at its rear end as indicated at 420, the rearouter face 422 of the sleeve being perpendicular to the longitudinal axis of the sleeve to provide a seat for the bases of the frustoconical portions 424 of theplunger 426, in the manner shown in greater detail in the US. Pat. to Sarnoff et al. No. 2,832,339. When desired, the rear surface of the inner sleeve may be overlaid with ametal washer 427, in which case it is desirable to provide a guide and holdingflange 428 to surround the opening 420, the flange having a turned overportion 430 to hold the washer in place. The interior wall of theinner sleeve 402 is provided with a number of equally circumferentially spacedlongitudinal ribs 432 to guide the wide seat por tion 434 of the plunger in its movement and direct it into theampoule 436 of the cartridge. Under compression, between theseat 434 of theplunger 426 and the inner surface of the rear end of theinner sleeve 402, is a'coil spring 438. The rear end of theplunger 426 is furcated and springy. The furcations of the plunger can be compressed together against its springy force by telescopic movement of theouter sleeve 400 relative to theinner sleeve 402, the cam orbevelled surface 418 then engaging the conical surfaces 424 and squeezing the furcations toward each other sufficiently to enable the frusto-conical portions to move forwardly through the opening 420, thus releasing theplunger 406 to the action of thespring 438. To prevent accidental release of the frusto-conical portions 424 off the seat provided therefor, a safety pin is provided in the form of acap 442 to be applied to the rear of theouter sleeve 400 and apin portion 444 to enter between the tines of the furcations, to inhibit their being squeezed together.

Theinner sleeve 402 andplunger 426, when the spring is compressed, extend only partially of the length of the outer sleeve, so as to permit of insertion of thecartridge holder 404 into the outer sleeve, with the rear end of theholder 404 abutting the forward end of theinner sleeve 402. In viewof the length of thecartridge 406, theinner sleeve 402 extends a little less than half way of the length of theouter sleeve 400. With a different length cartridge the length ofinner sleeve 402 would be different.

The cartridge itself comprises theampoule 436 having therewithin a liquid orliquid medication 446 with apiston 448 at one end and acannula 450 at the other end. Within the neck of theampoule 436, between the rear end of the cannula and the medicament there may be interposed a fluid pressure rupturable diaphragm 452, as is well known in the art. The internal diameter of theampoule 436 is larger than the diameter of theseat 434 of theplunger 426 to allow free movement of the plunger in the ampoule when the plunger is released to the action of thespring 438. The cartridge may be of the type shown in the Sarnoff US. Pat. No. 3,391 ,695 issued July 9,1968.

Thecartridge holder 404 is substantially of the same external diameter at its rear portion as theinner sleeve 402. The forward end of theholder 404 is of reduced diameter to provide ashoulder 454 to cooperate withseat 412 in effecting a coupling of the holder and outer sleeve. The extreme forward end of the holder is tapered as indicated at 456 and acannula puncturable stopper 458 of rubber or the like hermetically seals the apertured end of the holder. The rear end of the holder is sealed by resilient contact between the exterior surface of the ampoule and anannular bead 460 formed close to the rear end of theholder 404. The resiliency is obtained by making theholder 404, orbead 460, orampoule 436 of resilient material. The diameter of the exterior of the ampoule is less than the internal diameter of theholder 404 throughout the major length of the holder so that once the cartridge is thrust forward to free it from thebead 460, and the cannula has pierced the stopper, the cartridge is free to move in the holder, the gas in front of the cartridge passing freely past the walls of the ampoule to the rear thereof. By sealing off the interior of theholder 404, the contents thereof may be placed in and maintained in a sterile atmosphere. The interior of the holder at its forward end is contoured to form aseat 462 for the forward end of the ampoule when it is advanced in the holder. The overall length of the cartridge is such that all of it is contained within the holder.

In the use of the form of invention disclosed in FIGS. 14 to 17, the parts are furnished to the user thereof cocked as illustrated in FIG. 14.

In use, initially thesafety pin 444 is removed and then the forward end of theholder 404 is applied to the patient at the locus desired. Subsequently, when theouter sleeve 400 is thrust toward the patient, a telescoping action takes place between the outer and inner sleeves. An advantage of the arrangement of FIGS. 14 to 17 is that the outer sleeve is long and the injection device may be grasped very conveniently along substantially its entire length to operate it.

Telescoping action of thesleeves 400 and 402 causes thecam surface 418 to cam the furcations together, whereby they become smaller in diameter than the opening 420, and thespring 438 becomes effective to advance theplunger 426. The initial movement of the plunger, and as directed by theribs 432, causes the plunger to thrust against thepiston 448 within the ampoule. However, since the friction between thebead 460 and the ampoule coupled with the resistance to penetration of the stopper by the cannula is less than the force required to move the piston in the ampoule, the initial advance of the plunger results in a translation of the cartridge with respect to the holder whereby the cannula is unsheathed and the ampoule is brought into engagement with theseat 462. Subsequent advance of the plunger, under the force of thespring 438 causes the piston to advance in the ampoule, effecting passage of fluid by the diaphragm 452 and through thecannula 450. The action of parts is so rapid that advance of the cartridge and expulsion of medication appears to take place substantially simultaneously.

I claim:

1. A cylindrical cartridge holder and cartridge for use with a gun having a plunger for cooperation with said cartridge, said cartridge holder including means for positioning the holder in operative relationship with respect to the plunger, said holder being closed off at one end thereof, the cartridge comprising a cylindrical ampoule and fixedly attached cannula and fitting completely and movably within the holder with the cannula facing the closed holder end, said ampoule having an outer diameter less than the inner diameter of the cylindrical holder to form an annular space therebetween, sealing means on the inner surface of the cylindrical holder remote from its closed end and in engagement with the outer surface of the ampoule sealing the aforesaid annular space between the ampoule and holder at the ampoule end opposite the cannula whereby upon movement of the ampoule from the sealed position toward the closed end of the holder the seal is broken and free passage of gaseous fluid from in front of the ampoule to the rear thereof is provided by the aforesaid annular space.

2. The invention as set forth in claim 1 and wherein the ampoule is provided with a piston sea] at its end opposite the cannula and a liquid is contained in the ampoule between the cannula and the piston.

3. The cartridge holder and cartridge of claim 2 in combination with a gun, said gun having an inner sleeve aligned with the holder and an outer sleeve telescopically engaged with the inner sleeve and having means to fire the gun when telescoped.

4. The combination as set forth in claim 3 in which the gun includes a plunger, and in which the inner wall of the inner sleeve is provided with ribs running longitudinally of the sleeve to guide the plunger toward the piston.

5. A cartridge holder as set forth in claim 1 in which the ampoule includes a piston at one end thereof and a fluid in the ampoule between the piston and cannula and in which the ampoule also includes a diaphragm at the end thereof remote from the piston, said diaphragm being made of a material to allow passage of fluid therebeyond upon sufficient pressure being applied to the fluid by the piston.

6. A hypodermic injection device comprising in combination,

a gun,

a cartridge holder fixed in operative relationship to the gun and a cartridge including an ampoule with attached cannula within the holder,

said gun having a sleeve open at one end thereof, a plunger within the sleeve, potential energy means acting on said plunger tending to move it out of the open end of the sleeve, restraining means cooperative with said plunger to prevent plunger movement, safety means acting on said restraining means to render it inoperative,

said cartridge holder comprising a cylindrical shell acting as a prolongation of said gun sleeve, said shell at a free end thereof being closed off by a puncturable seal, annular sealing means on the interior portion of the shell remote from the closed end,

said cartridge comprising a cylindrical ampoule with a piston forming a seal in one end thereof, a fluid within said cylinder, the cannula affixed to the end of the cylinder opposite the piston, the cartridge, as a whole, movably fitting within the holder with the free end of the cannula within the holder at the closed-off end and the end, only, of the cartridge remote from the cannula held in sealing engagement with sealing means on the interior portion of the holder shell to allow free passage of gaseous fluid from the advancing end of the cylinder to the rear end thereof as the cartridge is translated relative to the holder.

7. The device of claim 6 wherein the ampoule further includes a diaphragm at the end thereof opposite the piston, said diaphragm being made of a material to allow passage of fluid therebeyond upon sufficient pressure being applied to the medicament by the piston.

8. The invention as set forth in claim 6 and wherein the gun plunger is provided with a head portion having a plurality of radially extending tabs adapted to engage the ampoule cylinder at its piston end.

9. The invention as set forth in claim 8 and wherein the plunger head is sized to fit within the ampoule cylinder.

10. The invention as set forth in claim 6 and wherein the gun and the cartridge holder with the cartridge therein are assembled within a single cylindrical housmg.

ll. The device of claim 6 and wherein ampoule engaging means are interposed between the gun plunger and the piston end of the ampoule whereby actuation of the gun plunger forces the ampoule engaging means and the ampoule to be moved toward the closed end of the cartridge holder.

12. The device ofclaim 11 and wherein abutment means are provided whereby upon prescribed moveand continued movement of the gun plunger causes the tabs to be disengaged from the ampoule whereupon the gun plunger continues its travel pushing the ampoule piston ahead ofit to eject the ampoule fluidv

Claims (13)

1. A cylindrical cartridge holder and cartridge for use with a gun having a plunger for cooperation with said cartridge, said cartridge holder including means for positioning the holder in operative relationship with respect to the plunger, said holder being closed off at one end thereof, the cartridge comprising a cylindrical ampoule and fixedly attached cannula and fitting completely and movably within the holder with the cannula facing the closed holder end, said ampoule having an outer diameter less than the inner diameter of the cylindrical holder to form an annular space therebetween, sealing means on the inner surface of the cylindrical holder remote from its closed end and in engagement with the outer surface of the ampoule sealing the aforesaid annular space between the ampoule and holder at the ampoule end opposite the cannula whereby upon movement of the ampoule from the sealed position toward the closed end of the holder the seal is broken and free passage of gaseous fluid from in front of the ampoule to the rear thereof is provided by the aforesaid annular space.

2. The invention as set forth in claim 1 and wherein the ampoule is provided with a piston seal at its end opposite the cannula and a liquid is contained in the ampoule between the cannula and the piston.

3. The cartridge holder and cartridge of claim 2 in combination with a gun, said gun having an inner sleeve aligned with the holder and an outer sleeve telescopically engaged with the inner sleeve and having means to fire the gun when telescoped.

4. The combination as set forth in claim 3 in which the gun includes a plunger, and in which the inner wall of the inner sleeve is provided with ribs running longitudinally of the sleeve to guide the plunger toward the piston.

5. A cartridge holder as set forth in claim 1 in which the ampoule includes a piston at one end thereof and a fluid in the ampoule between the piston and cannula and in which the ampoule also includes a diaphragm at the end thereof remote from the piston, said diaphragm being made of a material to allow passage of fluid therebeyond upon sufficient pressure being applied to the fluid by the piston.

6. A hypodermic injection device comprising in combination, a gun, a cartridge holder fixed in operative relationship to the gun and a cartridge including an ampoule with attached cannula within the holder, said gun having a sleeve open at one end thereof, a plunger within the sleeve, potential energy means acting on said plunger tending to move it out of the open end of the sleeve, restraining means cooperative with said plunger to prevent plunger movement, safety means acting on said restraining means to render it inoperative, said cartridge holder comprising a cylindrical shell acting as a prolongation of said gun sleeve, said shell at a free end thereof being closed off by a puncturable seal, annular sealing means on the interior portion of the shell remote from the closed end, said cartridge comprising a cylindrical ampoule with a piston forming a seal in one end thereof, a fluid within said cylinder, the cannula affixed to the end of the cylinder opposite the piston, the cartridge, as a whole, movably fitting within the holder with the free end of the cannula within the holder at the closed-off end and the end, only, of the cartridge remote from the cannula held in sealing engagement with sealing means on the interior portion of the holder shell to allow free passage of gaseous fluid from the advancing end of the cylinder to the rear end thereof as the cartridge is translated relative to the holder.

7. The device of claim 6 wherein the ampoule further includes a diaphragm at the end thereof opposite the piston, said diaphragm being made of a material to allow passage of fluid therebeyond upon sufficient pressure being applied to the medicament by the piston.

8. The invention as set forth in claim 6 and wherein the gun plunger is provided with a head portion having a plurality of radially extending tabs adapted to engage the ampoule cylinder at its piston end.

9. The invention as set forth in claim 8 and wherein the plunger head is sized to fit within the ampoule cylinder.

10. The invention as set forth in claim 6 and wherein the gun and the cartridge holder with the cartridge therein are assembled within a single cylindrical housing.

11. The device of claim 6 and wherein ampoule engaging means are interposed between the gun plunger and the piston end of the ampoule whereby actuation of the gun plunger forces the ampoule engaging means and the ampoule to be moved toward the closed end of the cartridge holder.

12. The device of claim 11 and wherein abutment means are provided whereby upon prescribed movement of the ampoule the ampoule engaging means are disengaged from the ampoule and the gun plunger then continues to move forward pushing the piston ahead of it to eject the ampoule fluid.

13. The device of claim 8 and wherein the tabs are integral with the head portion and have weakened portions to provide for deflection, and further wherein abutment means are provided on the cartridge holder whereby upon prescribed movement of the ampoule the abutment means stop the travel of said ampoule and continued movement of the gun plunger causes the tabs to be disengaged from the ampoule whereupon the gun plunger continues its travel pushing the ampoule piston ahead of it to eject the ampoule fluid.

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