US3656185A - Cardiac valvular support prosthesis - Google Patents
Cardiac valvular support prosthesisDownload PDFInfo
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- US3656185A US3656185AUS8564AUS3656185DAUS3656185AUS 3656185 AUS3656185 AUS 3656185AUS 8564 AUS8564 AUS 8564AUS 3656185D AUS3656185D AUS 3656185DAUS 3656185 AUS3656185 AUS 3656185A
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- annular
- elongated member
- cusps
- valve support
- cardiac valve
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
- A61F2/2445—Annuloplasty rings in direct contact with the valve annulus
- A61F2/2448—D-shaped rings
Definitions
- ABSTRACTA cardiac valvular prosthesis, e.g., for the mitral valve, consisting solely of an annular or part-annular member adapted to fit against the base of the cusps of a human heart valve, and suture means for securing the member in place.
- the prosthesiscooperates with the natural valve cusps of the patient to form the valve.
- the present inventionrelates to a prosthesis intended for the surgical correction of valvular diseases and notably diseases affecting the mitral valve.
- Such a prosthesisis described in US. Pat. No. 3,374,489 and includes an annular member which is inserted into the mitral ring and a valve disc provided with hooks, the disc oscillating between two extreme positions and alternately opening and closing the mitral orifice.
- the annular memberperforms the double function of retaining the valve disc and constituting the valve seat.
- Such a prosthesishas various disadvantages, in that it interferes with the normal physiology of the mitral apparatus, it necessitates the prolonged use of anticoagulants and it may cause a thrombosis or a sudden mechanical defect.
- a cardiac valvular prosthesisconsisting solely of an annular or partannular member adapted to fit against the base of the cusps of a human heart valve, and suture means for securing the member in place.
- the annular or part-annular membermay consist of a rigid frame, suture means and a textile sheath enclosing the frame and suture means.
- FIG. 1is an elevation of one embodiment of prosthesis according to the invention
- FIG. 2is a section taken along the line AA, of FIG. 1, and drawn to a large scale;
- FIG. 3is a view of the mitral valve in the course of the positioning of the prosthesis of FIG. 1;
- FIG. 4is a view of the mitral valve after the positioning of the prosthesis of FIG. 1;
- FIG. 5is an elevation of a second embodiment of prosthesis according to the invention.
- FIG. 6is a view of the mitral valve after the the prosthesis according to FIG. 5.
- the prosthesis shown in FIG. 1closely follows the form of the base of the valve cusps and it has substantially the form of a closed ring 1, which is plane, circular, oval or, as shown, slightly flattened at 2 over a length between one-quarter and one-half of its periphery.
- Substantially straight portion 2corresponds to the curvature of the large cusp and the complementary zone corresponds to the curvature of the small cusp.
- the ringhas in its plane an axis of symmetry, its largest dimensions, along this axis and along a perpendicular axis, being generally between and 30 mm. and and 40 mm. respectively.
- the ringcomprises a rigid frame ⁇ , for example of stainless steel.
- This frameis light since it has an asymmetric, outwardly hollow channel section defining an extemal groove.
- the flanges of the channel sectionare of unequal widths, the lower edge 4, which is flat being narrower positioning of and intended to rest on the mitral ring, while the upper flange 5 has a rounded profile.
- the width of the lower flangeis generally between 0.5 and 2 mm. and that of the upper flange between I and 3 mm. This arrangement makes it possible for the suture stitches to be automatically embedded.
- a stitchable cord 6,which is maintained within the groove by a filament 8 of large caliber, formed for example of polytetrafluorethylene.
- the ringalso comprises a woven textile sheath 7, for example also of polytetrafluorethylene, which simultaneously encloses or covers the frame 3 and the cord 6.
- a prosthesis according to the inventionmay be made from any inert materials which are well tolerated by the organism and have appropriate strength, and stainless steel and polytetrafluorethylene have only been referred to by way of example.
- stainless steel and polytetrafluorethylenehave only been referred to by way of example.
- ethyleneglycol polyterephthalatemay be used instead of polytetrafluoroethylene.
- the prosthesismay be in the form of an open ring, i.e., it may be part of an annulus 1, which is slightly flattened to fit closely against the base of the cusps.
- This part-annulusis open over a length generally between onequarter and one-half of its periphery, so that the space between the free ends is between one-third and one times the peripheral length of the part annular member itself.
- This lengthcorresponds substantially to the length of the base of the cusp which it is desired to allow to have free movement.
- the ringis open over a length equal to one-third of its periphery, this length corresponding substantially to the base of the large cusp 12. The ring thus closely fits against the base of the small cusp 13 and allows the large cusp to have free movement.
- the ends 14 and 15 of the ringare rounded in order not to damage the tissues in which they are disposed.
- the profile of the ringis similar to that of the construction of FIGS. 1 to 4, i.e., its cross section is as shown in FIG. 2.
- ithas an external groove, the lower flange intended to rest on the mitral ring again being plane, while the upper edge has a rounded profile.
- a largecaliber filament of polytetrafluoroethylene or of ethyleneglycol polyterephthalatewhich maintains a stitchable cord within the frame, after having been stretched between the two ends of the frame.
- the ends of the frameare each formed with a hole, the filament is pulled between these holes and is fused on either side of the holes so as to produce beads, and then released.
- FIGS. 1 to 4The annular mitral prosthesis of FIGS. 1 to 4 is positioned between the left auricle and the left ventricle by the surgical technique described below with reference to FIGS. 3 and 4.
- the dilatation of the mitral ringis checked, and it is verified that the cusps are sufficiently supple, that the large cusp has sufficient freedom of movement and that there is no lesion of the ligaments by which the large cusp is fixed.
- Two appropriate suture filaments l0 and 11are disposed in U-form and stitched with the aid of a needle into the thickness of the mitral ring, parallel to the latter, at the ends of the large cusp 12.
- the distance between these two filamentscorresponds to the width of the flattened zone 2 of the annular prosthesis and permits of defining the dimension of the prosthesis appropriate for the orifice under consideration.
- the prosthesisis then slid along the filaments against the mitral ring and thereafter fixed by knotting the filaments.
- the knotsare substantially invisible and the projection of the prosthesis is insignificant, so that it can be rapidly overlapped and incorporated by the neighboring organic tissues.
- the surgical technique of positioning the open ringis similar to that described above.
- the described prosthesispermit of treating mitral inadequacies due, for example, to contraction of the large cusp, to
- a prosthesis according to the inventionhas many advantages other than its simplicity and its safety of use. Owing to its particular form, it permits the preservation and repositioning of the valvular elements, as also the correction of various anomalies. For example, it permits repositioning and development of the large cusp, commissural remodelling, and reduction of the small cusp. Thus, it renders possible recontacting of the cusps in a mitral orifice of normal surface.
- the open ring prosthesispermits free movement of one of the cusps of a valve, notably the free movement of the large cusp in the mitral valve.
- the rigid frameit is possible to distribute the tractive forces over a large number of points and to counteract secondary distension of the mitral ring.
- the woven sheath to which the fibrin can adhereit is rapidly incorporated in the tissues and therefore requires no prolonged anticoagulant treatment and involves no danger of thrombosis.
- a prosthesis according to the inventionmay undergo various modifications of construction and may readily be adapted to other valves, notably to the tricuspid valve, by using a ring of the same type, of circular form, or to the aortic valve by using a ring adapted to the trifoliate form of the aortic valvular orifice.
- a cardiac valve supportfor supporting the cusps of a natural human heart valve without excising said valve and cusps, consisting solely of: an elongated member curved along its length to define a generally ring-shaped rigid member of a size and shape to fit against the base of the cusps of a natural human heart valve, the central axis of said curved elongated member lying substantially in a single plane, and suture means for suturing the member in place, said suture means being substantially coextensive with said elongated member.
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- Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
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Abstract
Description
United States Patent Carpentier [54] CARDIAC VALVULAR SUPPORT PROSTHESIS [72] Inventor: Alain F. Carpentier, Paris, France [73] Assignee: Rhone-Poulenc S.A., Paris, France [22] Filed: Feb. 4, 1970 [2]] Appl. No.: 8,564
[30] Foreign Application Priority Data Feb. 4, 1969 France ..690244l Dec. 19, 1969 France ..6944124 [52] US. Cl "3/15 128534 R [5 1] Int. Cl. ..A61f 1/24 [58] Field olSearch ..3/l,DIG. 3; 128/334 R,1
[56] References Cited UNITED STATES PATENTS 3,396,409 8/1968 Meirose ..3/l
' OTHER PUBLICATIONS A Prosthetic Stented Aortic Homograft For Mitral Valve Replacement Q. S. Weldon et al., Journal of Surgical [151 3,656,185 [451 Apr. 18, 1972 Research, Vol. 6, No. 12, Dec. 1966, pgs. 548.- 552 Simplified Insertion of Aortic Homograft Valves With Nonthrombogenic Prosthetic Frames by Nina S. Braunwald et al., Transaction American Soc. For Artificial Internal 0rgans, vol. XIII, 1967, pgs. 1 l l- 113 The In Vivo Comparison of Hemodynamic Function of Bali, Disk, and Eccentric Monocusp Artifial IMitral Valves" by R. W. M. Frater et al., Prosthetic Heart Valves, Charles C. ThomasPublisher, Springfield, Illinois, I 968, pgs. 262- 266 Primary Examiner-Dalton L. Truluck Assistant Examiner-Ronald L. Frinks Attorney-Stevens, Davis, Miller & Mosher [57] ABSTRACT A cardiac valvular prosthesis, e.g., for the mitral valve, consisting solely of an annular or part-annular member adapted to fit against the base of the cusps of a human heart valve, and suture means for securing the member in place. The prosthesis cooperates with the natural valve cusps of the patient to form the valve.
6 Claims, 6 Drawing Figures PATENTEUAPR 18 1912 SHEET 1 OF 2 inventor V ALAIN CARPENTIER Attorney! PATENTEUAPR 18 1972 3,656,185
sum 2 [IF 2 Inventor BY ALAIN CARPENTIER mwws M Attorneys CARDIAC VALVULAR SUPPORT PROSTHESIS The present invention relates to a prosthesis intended for the surgical correction of valvular diseases and notably diseases affecting the mitral valve.
In the case of mitral disease, it is known to preserve the natural cusps of a valve and to correct the defects therein. However, Kays annuloplasty, Woolers asymmetrical annuloplasty and Reeds annuloplasty give uncertain results, because leakage may persist. In addition, the mitral ring may continue to distend and the stitches made in the commissuroplasty may yield under the action of the tensile forces to which they are subjected. This results in a reduction in the efficiency of the valve with a frequency which is given as to 40 percent by the authors.
It is also known, in order to obviate valvular deformation, especially mitral valve deformation, to proceed with ablation of the defective cusps and to replace them by a prosthesis.
Such a prosthesis is described in US. Pat. No. 3,374,489 and includes an annular member which is inserted into the mitral ring and a valve disc provided with hooks, the disc oscillating between two extreme positions and alternately opening and closing the mitral orifice. The annular member performs the double function of retaining the valve disc and constituting the valve seat.
Such a prosthesis has various disadvantages, in that it interferes with the normal physiology of the mitral apparatus, it necessitates the prolonged use of anticoagulants and it may cause a thrombosis or a sudden mechanical defect.
According to the present invention, there is provided a cardiac valvular prosthesis consisting solely of an annular or partannular member adapted to fit against the base of the cusps of a human heart valve, and suture means for securing the member in place. With such a prosthesis the natural valve cusps are retained, and the prosthesis is inserted at the base thereof.
The annular or part-annular member may consist of a rigid frame, suture means and a textile sheath enclosing the frame and suture means.
The invention will be more readily understood from the following description, given merely by way of example reference being made to the accompanying drawings, in which:
FIG. 1 is an elevation of one embodiment of prosthesis according to the invention;
FIG. 2 is a section taken along the line AA, of FIG. 1, and drawn to a large scale;
FIG. 3 is a view of the mitral valve in the course of the positioning of the prosthesis of FIG. 1;
FIG. 4 is a view of the mitral valve after the positioning of the prosthesis of FIG. 1;
FIG. 5 is an elevation of a second embodiment of prosthesis according to the invention; and
FIG. 6 is a view of the mitral valve after the the prosthesis according to FIG. 5.
The prosthesis shown in FIG. 1 closely follows the form of the base of the valve cusps and it has substantially the form of a closed ring 1, which is plane, circular, oval or, as shown, slightly flattened at 2 over a length between one-quarter and one-half of its periphery. Substantiallystraight portion 2 corresponds to the curvature of the large cusp and the complementary zone corresponds to the curvature of the small cusp. The ring has in its plane an axis of symmetry, its largest dimensions, along this axis and along a perpendicular axis, being generally between and 30 mm. and and 40 mm. respectively.
As seen in FIG. 2, the ring comprises a rigid frame}, for example of stainless steel. This frame is light since it has an asymmetric, outwardly hollow channel section defining an extemal groove. The flanges of the channel section are of unequal widths, thelower edge 4, which is flat being narrower positioning of and intended to rest on the mitral ring, while theupper flange 5 has a rounded profile. The width of the lower flange is generally between 0.5 and 2 mm. and that of the upper flange between I and 3 mm. This arrangement makes it possible for the suture stitches to be automatically embedded.
Within the groove is disposed a stitchable cord 6, which is maintained within the groove by afilament 8 of large caliber, formed for example of polytetrafluorethylene. The ring also comprises a woven textile sheath 7, for example also of polytetrafluorethylene, which simultaneously encloses or covers theframe 3 and the cord 6.
A prosthesis according to the invention may be made from any inert materials which are well tolerated by the organism and have appropriate strength, and stainless steel and polytetrafluorethylene have only been referred to by way of example. For example ethyleneglycol polyterephthalate may be used instead of polytetrafluoroethylene.
As seen in FIG. 5 and 6, the prosthesis may be in the form of an open ring, i.e., it may be part of an annulus 1, which is slightly flattened to fit closely against the base of the cusps. This part-annulus is open over a length generally between onequarter and one-half of its periphery, so that the space between the free ends is between one-third and one times the peripheral length of the part annular member itself. This length corresponds substantially to the length of the base of the cusp which it is desired to allow to have free movement. In FIGS. 5 and 6, the ring is open over a length equal to one-third of its periphery, this length corresponding substantially to the base of thelarge cusp 12. The ring thus closely fits against the base of thesmall cusp 13 and allows the large cusp to have free movement.
Theends
The profile of the ring is similar to that of the construction of FIGS. 1 to 4, i.e., its cross section is as shown in FIG. 2. Thus, it has an external groove, the lower flange intended to rest on the mitral ring again being plane, while the upper edge has a rounded profile. Situated inside the groove is a largecaliber filament of polytetrafluoroethylene or of ethyleneglycol polyterephthalate, which maintains a stitchable cord within the frame, after having been stretched between the two ends of the frame. For this purpose, the ends of the frame are each formed with a hole, the filament is pulled between these holes and is fused on either side of the holes so as to produce beads, and then released.
The annular mitral prosthesis of FIGS. 1 to 4 is positioned between the left auricle and the left ventricle by the surgical technique described below with reference to FIGS. 3 and 4.
First of all, the dilatation of the mitral ring is checked, and it is verified that the cusps are sufficiently supple, that the large cusp has sufficient freedom of movement and that there is no lesion of the ligaments by which the large cusp is fixed.
Two appropriate suture filaments l0 and 11 are disposed in U-form and stitched with the aid of a needle into the thickness of the mitral ring, parallel to the latter, at the ends of thelarge cusp 12. The distance between these two filaments corresponds to the width of theflattened zone 2 of the annular prosthesis and permits of defining the dimension of the prosthesis appropriate for the orifice under consideration.
About 20 filaments constituting as many absolutely equidistant stitches are positioned in the same way between the filaments l0 and 11 and around the whole periphery of the mitral ring, at the base of the cusps and immediately above. These filaments are then passed through the cord of the prosthesis, with an identical spacing for the filaments corresponding to the large cusp and with a reduced spacing for the filaments corresponding to thesmall cusp 13.
The prosthesis is then slid along the filaments against the mitral ring and thereafter fixed by knotting the filaments. The knots are substantially invisible and the projection of the prosthesis is insignificant, so that it can be rapidly overlapped and incorporated by the neighboring organic tissues.
The surgical technique of positioning the open ring is similar to that described above.
The described prosthesis permit of treating mitral inadequacies due, for example, to contraction of the large cusp, to
' opening of the commissural curvatures, to distension of the mitral ring in the zone of attachment of the small cusp, and so on. They also permit, after commissurotomy, of treating an orificial stricture due to a fibrous fusion of the commissures.
A prosthesis according to the invention has many advantages other than its simplicity and its safety of use. Owing to its particular form, it permits the preservation and repositioning of the valvular elements, as also the correction of various anomalies. For example, it permits repositioning and development of the large cusp, commissural remodelling, and reduction of the small cusp. Thus, it renders possible recontacting of the cusps in a mitral orifice of normal surface. The open ring prosthesis permits free movement of one of the cusps of a valve, notably the free movement of the large cusp in the mitral valve. In addition, owing to the rigid frame it is possible to distribute the tractive forces over a large number of points and to counteract secondary distension of the mitral ring. Finally, owing to the woven sheath to which the fibrin can adhere, it is rapidly incorporated in the tissues and therefore requires no prolonged anticoagulant treatment and involves no danger of thrombosis.
Although only two particular embodiments of mitral prosthesis have been described by way of example, a prosthesis according to the invention may undergo various modifications of construction and may readily be adapted to other valves, notably to the tricuspid valve, by using a ring of the same type, of circular form, or to the aortic valve by using a ring adapted to the trifoliate form of the aortic valvular orifice.
Iclaim:
l. A cardiac valve support for supporting the cusps of a natural human heart valve without excising said valve and cusps, consisting solely of: an elongated member curved along its length to define a generally ring-shaped rigid member of a size and shape to fit against the base of the cusps of a natural human heart valve, the central axis of said curved elongated member lying substantially in a single plane, and suture means for suturing the member in place, said suture means being substantially coextensive with said elongated member.
2. A cardiac valve support as claimed in claim 1, wherein the elongated member comprises a rigid frame, and wherein said frame and suture means are enclosed in a textile sheath.
3. A cardiac valve support as claimed inclaim 2, wherein said frame comprises an asymmetric, outwardly hollow, channel section having unequal length flanges defining an external groove, and said suture means comprises a suturable cord disposed within said external groove.
4. A cardiac valve support as claimed inclaim 3, wherein a reinforcing filament extends along said elongated member within said cord.
5. A cardiac valve support as claimed in claim 1, wherein said elongated member is curved in an annular shape, including a circular sector portion and a substantially straight portion together defining the annular periphery of said elongated member, said straight portion comprising between onequarter and one-half of said periphery.
6. A cardiac valve support as claimed in claim 1, wherein said member is a part-annular member curved in an annular shape but omitting between one-quarter and one-half of the total peripheral length of said total annular shape, said partannular member having spaced apart ends, the annular arcuate spacing between said ends being not less than about one third of the actual peripheral length of said part-annular member.
Claims (6)
1. A cardiac valve support for supporting the cusps of a natural human heart valve without excising said valve and cusps, consisting solely of: an elongated member curved along its length to define a generally ring-shaped rigid member of a size and shape to fit against the base of the cusps of a natural human heart valve, the central axis of said curved elongated member lying substantially in a single plane, and suture means for suturing the member In place, said suture means being substantially coextensive with said elongated member.
2. A cardiac valve support as claimed in claim 1, wherein the elongated member comprises a rigid frame, and wherein said frame and suture means are enclosed in a textile sheath.
3. A cardiac valve support as claimed in claim 2, wherein said frame comprises an asymmetric, outwardly hollow, channel section having unequal length flanges defining an external groove, and said suture means comprises a suturable cord disposed within said external groove.
4. A cardiac valve support as claimed in claim 3, wherein a reinforcing filament extends along said elongated member within said cord.
5. A cardiac valve support as claimed in claim 1, wherein said elongated member is curved in an annular shape, including a circular sector portion and a substantially straight portion together defining the annular periphery of said elongated member, said straight portion comprising between one-quarter and one-half of said periphery.
6. A cardiac valve support as claimed in claim 1, wherein said member is a part-annular member curved in an annular shape but omitting between one-quarter and one-half of the total peripheral length of said total annular shape, said part-annular member having spaced apart ends, the annular arcuate spacing between said ends being not less than about one third of the actual peripheral length of said part-annular member.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR6902441AFR2031699A5 (en) | 1969-02-04 | 1969-02-04 | |
| FR6944124AFR2071172A6 (en) | 1969-12-19 | 1969-12-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US3656185Atrue US3656185A (en) | 1972-04-18 |
Family
ID=26214822
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US8564AExpired - LifetimeUS3656185A (en) | 1969-02-04 | 1970-02-04 | Cardiac valvular support prosthesis |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US3656185A (en) |
| JP (1) | JPS504999B1 (en) |
| BE (1) | BE745427A (en) |
| CA (1) | CA930503A (en) |
| CH (1) | CH508395A (en) |
| CS (1) | CS163762B2 (en) |
| DE (1) | DE2005112C3 (en) |
| GB (1) | GB1293014A (en) |
| IL (1) | IL33838A (en) |
| LU (1) | LU60294A1 (en) |
| NL (1) | NL143127B (en) |
| NO (1) | NO123299B (en) |
| SE (1) | SE357140B (en) |
| SU (1) | SU365053A3 (en) |
Cited By (294)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3908201A (en)* | 1972-06-30 | 1975-09-30 | Ici Ltd | Prosthetics |
| US4042979A (en)* | 1976-07-12 | 1977-08-23 | Angell William W | Valvuloplasty ring and prosthetic method |
| US4042978A (en)* | 1972-06-30 | 1977-08-23 | Imperial Chemical Industries Limited | Prosthetics |
| US4055861A (en)* | 1975-04-11 | 1977-11-01 | Rhone-Poulenc Industries | Support for a natural human heart valve |
| US4164046A (en)* | 1977-05-16 | 1979-08-14 | Cooley Denton | Valve prosthesis |
| US4204283A (en)* | 1977-05-05 | 1980-05-27 | National Research Development Corporation | Prosthetic valve |
| US4217665A (en)* | 1975-06-23 | 1980-08-19 | Societe D'utilisation Scientifique Et Industrielle Du Froid - Usifroid | Prosthesis for use in valvuloplasty |
| US4290151A (en)* | 1979-07-31 | 1981-09-22 | Massana Miguel P | Adjustable annular prosthesis for cardiac surgery |
| US4489446A (en)* | 1982-07-14 | 1984-12-25 | Reed Charles C | Heart valve prosthesis |
| US4865600A (en)* | 1981-08-25 | 1989-09-12 | Baxter International Inc. | Mitral valve holder |
| EP0338994A1 (en)* | 1988-01-12 | 1989-10-25 | Mario Morea | Prosthetic device for the surgical correction of tricuspid insufficiency |
| US4917698A (en)* | 1988-12-22 | 1990-04-17 | Baxter International Inc. | Multi-segmented annuloplasty ring prosthesis |
| US5041130A (en)* | 1989-07-31 | 1991-08-20 | Baxter International Inc. | Flexible annuloplasty ring and holder |
| US5061277A (en)* | 1986-08-06 | 1991-10-29 | Baxter International Inc. | Flexible cardiac valvular support prosthesis |
| WO1991019465A1 (en)* | 1990-06-07 | 1991-12-26 | Robert William Mayo Frater | Mitral heart valve replacements |
| US5104407A (en)* | 1989-02-13 | 1992-04-14 | Baxter International Inc. | Selectively flexible annuloplasty ring |
| US5258023A (en)* | 1992-02-12 | 1993-11-02 | Reger Medical Development, Inc. | Prosthetic heart valve |
| US5350420A (en)* | 1989-07-31 | 1994-09-27 | Baxter International Inc. | Flexible annuloplasty ring and holder |
| WO1995003757A1 (en)* | 1993-08-03 | 1995-02-09 | Jacques Seguin | Prosthetic ring for use in cardiac surgery |
| WO1995006447A1 (en)* | 1993-08-31 | 1995-03-09 | W.L. Gore & Associates, Inc. | Improved device for tissue repair and method for employing same |
| US5562729A (en)* | 1994-11-01 | 1996-10-08 | Biocontrol Technology, Inc. | Heart valve |
| US5674279A (en)* | 1992-01-27 | 1997-10-07 | Medtronic, Inc. | Annuloplasty and suture rings |
| US5776189A (en)* | 1997-03-05 | 1998-07-07 | Khalid; Naqeeb | Cardiac valvular support prosthesis |
| US5824066A (en)* | 1995-12-01 | 1998-10-20 | Medtronic, Inc. | Annuloplasty prosthesis |
| WO1999029269A1 (en)* | 1997-12-05 | 1999-06-17 | St. Jude Medical, Inc. | Annuloplasty ring with cut zone |
| US6024096A (en)* | 1998-05-01 | 2000-02-15 | Correstore Inc | Anterior segment ventricular restoration apparatus and method |
| US6102945A (en)* | 1998-10-16 | 2000-08-15 | Sulzer Carbomedics, Inc. | Separable annuloplasty ring |
| WO2000062715A1 (en) | 1999-04-16 | 2000-10-26 | Edwards Lifesciences Corporation | Aortic annuloplasty ring |
| US6143024A (en)* | 1998-06-04 | 2000-11-07 | Sulzer Carbomedics Inc. | Annuloplasty ring having flexible anterior portion |
| WO2000074603A1 (en)* | 1999-06-08 | 2000-12-14 | S & A Rings, Llc | Annuloplasty rings for heart valve replacement and repair |
| US6221104B1 (en) | 1998-05-01 | 2001-04-24 | Cor Restore, Inc. | Anterior and interior segment cardiac restoration apparatus and method |
| US6254636B1 (en) | 1998-06-26 | 2001-07-03 | St. Jude Medical, Inc. | Single suture biological tissue aortic stentless valve |
| US6283993B1 (en) | 1989-07-31 | 2001-09-04 | Edwards Lifesciences Corporation | Annuloplasty ring delivery system |
| US6306133B1 (en) | 1999-10-02 | 2001-10-23 | Quantum Cor Incorporated | Ablation catheter system and methods for repairing a valvular annulus |
| US6312464B1 (en) | 1999-04-28 | 2001-11-06 | NAVIA JOSé L. | Method of implanting a stentless cardiac valve prosthesis |
| US6348068B1 (en) | 1999-07-23 | 2002-02-19 | Sulzer Carbomedics Inc. | Multi-filament valve stent for a cardisc valvular prosthesis |
| WO2002015798A2 (en) | 2000-08-25 | 2002-02-28 | Sulzer Carbomedics Inc. | Method and apparatus for stapling an annuloplasty band in-situ |
| US6406492B1 (en) | 1999-04-08 | 2002-06-18 | Sulzer Carbomedics Inc. | Annuloplasty ring holder |
| US20020077524A1 (en)* | 1997-01-02 | 2002-06-20 | Myocor, Inc. | Heart wall tension reduction apparatus |
| US20020169359A1 (en)* | 1997-01-02 | 2002-11-14 | Myocor, Inc. | Methods and devices for improving cardiac function in hearts |
| US6485489B2 (en) | 1999-10-02 | 2002-11-26 | Quantum Cor, Inc. | Catheter system for repairing a mitral valve annulus |
| US20020188350A1 (en)* | 2001-06-11 | 2002-12-12 | Pietro Arru | Annuloplasty prosthesis and a method for its manufacture |
| US6544167B2 (en) | 1998-05-01 | 2003-04-08 | Correstore, Inc. | Ventricular restoration patch |
| US20030069570A1 (en)* | 1999-10-02 | 2003-04-10 | Witzel Thomas H. | Methods for repairing mitral valve annulus percutaneously |
| US20030074012A1 (en)* | 2000-10-10 | 2003-04-17 | Coalescent Surgical, Inc. | Minimally invasive annuloplasty procedure and apparatus |
| US6569198B1 (en) | 2000-03-31 | 2003-05-27 | Richard A. Wilson | Mitral or tricuspid valve annuloplasty prosthetic device |
| US20030125805A1 (en)* | 2002-01-02 | 2003-07-03 | Medtronic, Inc. | Heart valve system |
| US20030176917A1 (en)* | 2002-03-18 | 2003-09-18 | Medtronic, Inc. | Flexible annuloplasty prosthesis and holder |
| US20030208264A1 (en)* | 2001-08-28 | 2003-11-06 | Mccarthy Patrick M. | Three-dimensional annuloplasty ring and template |
| US20030220686A1 (en)* | 2002-03-27 | 2003-11-27 | Pietro Arru | Prosthesis for annuloplasty comprising a perforated element |
| US6669725B2 (en) | 2000-12-28 | 2003-12-30 | Centerpulse Biologics Inc. | Annuloplasty ring for regeneration of diseased or damaged heart valve annulus |
| US20040024451A1 (en)* | 2002-01-02 | 2004-02-05 | Medtronic, Inc. | Prosthetic heart valve system |
| US20040054303A1 (en)* | 2002-07-29 | 2004-03-18 | Taylor Geoffrey L. | Blanching response pressure sore detector apparatus and method |
| US6730121B2 (en) | 2000-07-06 | 2004-05-04 | Medtentia | Annuloplasty devices and related heart valve repair methods |
| US6749630B2 (en) | 2001-08-28 | 2004-06-15 | Edwards Lifesciences Corporation | Tricuspid ring and template |
| DE10301023A1 (en)* | 2003-01-13 | 2004-07-22 | Medos Medizintechnik Ag | Implant, in particular ring for heart valve, designed in curved and asymmetric shape |
| US20040186564A1 (en)* | 2002-03-18 | 2004-09-23 | Ryan Timothy R. | Annuloplasty system |
| US20040193191A1 (en)* | 2003-02-06 | 2004-09-30 | Guided Delivery Systems, Inc. | Devices and methods for heart valve repair |
| US20040243227A1 (en)* | 2002-06-13 | 2004-12-02 | Guided Delivery Systems, Inc. | Delivery devices and methods for heart valve repair |
| US20050021135A1 (en)* | 2001-03-15 | 2005-01-27 | Ryan Timothy R. | Annuloplasty band and method |
| US20050038509A1 (en)* | 2003-08-14 | 2005-02-17 | Ashe Kassem Ali | Valve prosthesis including a prosthetic leaflet |
| US20050043791A1 (en)* | 2001-08-28 | 2005-02-24 | Mccarthy Patrick M. | Three-dimensional annuloplasty ring and template |
| US20050065396A1 (en)* | 1998-09-21 | 2005-03-24 | Myocor, Inc. | External stress reduction device and method |
| US20050107811A1 (en)* | 2002-06-13 | 2005-05-19 | Guided Delivery Systems, Inc. | Delivery devices and methods for heart valve repair |
| US20050107810A1 (en)* | 2002-06-13 | 2005-05-19 | Guided Delivery Systems, Inc. | Devices and methods for heart valve repair |
| US20050131533A1 (en)* | 2001-05-17 | 2005-06-16 | Ottavio Alfieri | Annuloplasty rings for repair of abnormal mitral valves |
| US20050149178A1 (en)* | 2000-07-06 | 2005-07-07 | Medtentia Ab | Annuloplasty instrument |
| US20050197696A1 (en)* | 2004-02-23 | 2005-09-08 | Gomez Duran Carlos M. | Papilloplasty band and sizing device |
| US20050237780A1 (en)* | 2004-04-21 | 2005-10-27 | Seiko Epson Corporation | Organic electroluminescent device, method of manufacture thereof and electronic apparatus |
| US20050246014A1 (en)* | 2004-04-29 | 2005-11-03 | Mccarthy Patrick M | Annuloplasty ring for mitral valve prolapse |
| US20050256567A1 (en)* | 2004-05-14 | 2005-11-17 | St. Jude Medical, Inc. | Heart valve annuloplasty prosthesis sewing cuffs and methods of making same |
| US20050256569A1 (en)* | 2004-05-14 | 2005-11-17 | St. Jude Medical, Inc. | Flexible, non-planar annuloplasty rings |
| US20050267572A1 (en)* | 2004-05-14 | 2005-12-01 | St. Jude Medical, Inc. | Systems and methods for holding annuloplasty rings |
| US20050273138A1 (en)* | 2003-12-19 | 2005-12-08 | Guided Delivery Systems, Inc. | Devices and methods for anchoring tissue |
| US20050278022A1 (en)* | 2004-06-14 | 2005-12-15 | St. Jude Medical, Inc. | Annuloplasty prostheses with improved anchoring structures, and related methods |
| US20060009799A1 (en)* | 2003-05-19 | 2006-01-12 | Kleshinski Stephen J | Embolic filtering method and apparatus |
| US20060025856A1 (en)* | 2001-03-15 | 2006-02-02 | Medtronic, Inc. | Annuloplasty band and method |
| US20060039756A1 (en)* | 2004-08-19 | 2006-02-23 | Bernd Lemke | Self-propelled device for milling road surfaces |
| US20060082069A1 (en)* | 2004-10-14 | 2006-04-20 | Malavazi Vedacoes Industriais Ltda | Bearing-supported mechanical seal for progressive cavity pumps |
| US20060122633A1 (en)* | 2002-06-13 | 2006-06-08 | John To | Methods and devices for termination |
| US7077862B2 (en) | 2002-01-09 | 2006-07-18 | Myocor, Inc. | Devices and methods for heart valve treatment |
| US20060190030A1 (en)* | 2002-06-13 | 2006-08-24 | John To | Methods and devices for termination |
| US7112219B2 (en) | 2002-11-12 | 2006-09-26 | Myocor, Inc. | Devices and methods for heart valve treatment |
| US20060217803A1 (en)* | 2005-03-23 | 2006-09-28 | Ingle Aaron S | Apparatus, system, and method for delivering an annuloplasty ring |
| US20060241656A1 (en)* | 2002-06-13 | 2006-10-26 | Starksen Niel F | Delivery devices and methods for heart valve repair |
| US20070055206A1 (en)* | 2005-08-10 | 2007-03-08 | Guided Delivery Systems, Inc. | Methods and devices for deployment of tissue anchors |
| US20070055303A1 (en)* | 2000-10-06 | 2007-03-08 | Myocor, Inc. | Endovascular splinting devices and methods |
| US20070071685A1 (en)* | 2003-12-22 | 2007-03-29 | Bracco Research S.A. | Gas-filled microvesicle assembly for contrast imaging |
| US20070078468A1 (en)* | 2005-09-30 | 2007-04-05 | Ryan Timothy R | Tool and method for implanting an annuloplasty prosthesis |
| WO2007040998A1 (en)* | 2005-09-30 | 2007-04-12 | Medtronic, Inc. | Flexible annuloplasty prosthesis |
| US20070123979A1 (en)* | 2005-06-27 | 2007-05-31 | Patrick Perier | Apparatus, system, and method for treatment of posterior leaflet prolapse |
| US20070129598A1 (en)* | 2001-09-07 | 2007-06-07 | Raman Jaishanker | Method and apparatus for external stabilization of the heart |
| US7229469B1 (en) | 1999-10-02 | 2007-06-12 | Quantumcor, Inc. | Methods for treating and repairing mitral valve annulus |
| US20070156234A1 (en)* | 2005-03-23 | 2007-07-05 | Vaso Adzich | Apparatus, system, and method for delivering an annuloplasty ring |
| US20070162112A1 (en)* | 2005-12-28 | 2007-07-12 | Sorin Biomedica Cardio | Annuloplasty prosthesis with an auxetic structure |
| US7247134B2 (en) | 2002-11-12 | 2007-07-24 | Myocor, Inc. | Devices and methods for heart valve treatment |
| US20070299513A1 (en)* | 2006-06-02 | 2007-12-27 | Ryan Timothy R | Annuloplasty ring and method |
| US20070299514A1 (en)* | 2006-06-02 | 2007-12-27 | Colvin Stephen B | Annuloplasty prosthesis with in vivo shape identification and related methods of use |
| US20080009941A1 (en)* | 2004-07-13 | 2008-01-10 | Hans Hinrich Sievers | Implant with an annular base |
| US20080058924A1 (en)* | 2006-09-01 | 2008-03-06 | Aaron Ingle | Saddle-shaped annuloplasty ring |
| US20080086203A1 (en)* | 2006-10-06 | 2008-04-10 | Roberts Harold G | Mitral and tricuspid annuloplasty rings |
| EP1913900A1 (en) | 2004-06-29 | 2008-04-23 | SIEVERS, Hans-Hinrich, Dr. | Implant with a ring-shaped base plate |
| US20080097593A1 (en)* | 2001-11-13 | 2008-04-24 | Bolling Steven F | Mitral Annuloplasty Ring Having Upward Bows |
| RU2324457C1 (en)* | 2007-01-09 | 2008-05-20 | Закрытое Акционерное Общество Научно-Производственное Предприятие "Мединж" | D-shaped ring for annuloplasty of tricuspid valve |
| US20080161825A1 (en)* | 2006-11-20 | 2008-07-03 | Stout Medical Group, L.P. | Anatomical measurement tool |
| US20080172035A1 (en)* | 2006-10-18 | 2008-07-17 | Starksen Niel F | Methods and devices for catheter advancement and delivery of substances therethrough |
| US20080177380A1 (en)* | 2007-01-19 | 2008-07-24 | Starksen Niel F | Methods and devices for heart tissue repair |
| US20080234728A1 (en)* | 2002-06-13 | 2008-09-25 | Guided Delivery Systems, Inc. | Devices and methods for heart valve repair |
| US20080234815A1 (en)* | 2003-09-04 | 2008-09-25 | Guided Delivery Systems, Inc. | Devices and methods for cardiac annulus stabilization and treatment |
| CN100421632C (en)* | 2005-02-01 | 2008-10-01 | 金磊 | artificial heart valvuloplasty ring |
| US20080262609A1 (en)* | 2006-12-05 | 2008-10-23 | Valtech Cardio, Ltd. | Segmented ring placement |
| US20080275551A1 (en)* | 2007-05-01 | 2008-11-06 | Edwards Lifesciences Corporation | Inwardly-bowed tricuspid annuloplasty ring |
| US20080319256A1 (en)* | 1998-07-29 | 2008-12-25 | Myocor, Inc. | Transventricular implant tools and devices |
| US20090076599A1 (en)* | 2007-09-17 | 2009-03-19 | Medtronics, Inc. | Heart valve holder assembly for use in valve implantation procedures |
| US7547313B2 (en) | 1998-06-03 | 2009-06-16 | Medtronic, Inc. | Tissue connector apparatus and methods |
| US20090157176A1 (en)* | 2007-02-09 | 2009-06-18 | Alain Carpentier | Annuloplasty rings for correcting degenerative valvular diseases |
| US20090157174A1 (en)* | 2005-12-15 | 2009-06-18 | Georgia Tech Reasearch Corporation | Systems and methods for enabling heart valve replacement |
| EP2075014A2 (en) | 2002-05-24 | 2009-07-01 | Angiotech International Ag | Compositions and methods for coating medical implants |
| US20090192606A1 (en)* | 2008-01-25 | 2009-07-30 | Medtronic, Inc. | Holder Devices for Annuloplasty Devices Having a Plurality of Anterior-Posterior Ratios |
| US20090222083A1 (en)* | 2008-02-06 | 2009-09-03 | Guided Delivery Systems Inc. | Multi-window guide tunnel |
| US20090234318A1 (en)* | 2007-10-19 | 2009-09-17 | Guided Delivery Systems, Inc. | Systems and methods for cardiac remodeling |
| US20090287187A1 (en)* | 2008-05-07 | 2009-11-19 | Guided Delivery Systems Inc. | Deflectable guide |
| US20090287303A1 (en)* | 2008-05-13 | 2009-11-19 | Edwards Lifesciences Corporation | Physiologically harmonized tricuspid annuloplasty ring |
| US20100010625A1 (en)* | 2002-07-08 | 2010-01-14 | Edwards Lifesciences Corporation | Mitral valve annuloplasty ring having an offset posterior bow |
| US20100023117A1 (en)* | 2005-12-15 | 2010-01-28 | Georgia Tech Research Corporation | Papillary muscle position control devices, systems, & methods |
| US20100049213A1 (en)* | 2007-10-19 | 2010-02-25 | Guided Delivery Systems Inc. | Devices and methods for termination |
| US20100063586A1 (en)* | 2006-05-15 | 2010-03-11 | John Michael Hasenkam | System and a method for altering the geometry of the heart |
| US20100076548A1 (en)* | 2008-09-19 | 2010-03-25 | Edwards Lifesciences Corporation | Prosthetic Heart Valve Configured to Receive a Percutaneous Prosthetic Heart Valve Implantation |
| US20100076549A1 (en)* | 2008-09-19 | 2010-03-25 | Edwards Lifesciences Corporation | Annuloplasty Ring Configured to Receive a Percutaneous Prosthetic Heart Valve Implantation |
| US20100082098A1 (en)* | 2002-06-13 | 2010-04-01 | Starksen Niel F | Delivery devices and methods for heart valve repair |
| US20100094314A1 (en)* | 2008-10-10 | 2010-04-15 | Hernlund Jonathan D | Tether tensioning devices and related methods |
| US20100121349A1 (en)* | 2008-10-10 | 2010-05-13 | Meier Stephen C | Termination devices and related methods |
| US7722643B2 (en) | 1999-03-01 | 2010-05-25 | Medtronic, Inc. | Tissue connector apparatus and methods |
| US20100137980A1 (en)* | 2001-05-17 | 2010-06-03 | Edwards Lifesciences Corporation | Annular Prosthesis for a Mitral Valve |
| US20100152844A1 (en)* | 2008-12-15 | 2010-06-17 | Couetil Jean-Paul A | Annuloplasty ring with directional flexibilities and rigidities to assist the mitral annulus dynamics |
| US20100161046A1 (en)* | 1999-01-26 | 2010-06-24 | Edwards Lifesciences Corporation | Holder for flexible heart valve |
| WO2010070649A1 (en) | 2008-12-21 | 2010-06-24 | Mor Research Applications Ltd. | Elongated body for deployment in a coronary sinus |
| US7744611B2 (en) | 2000-10-10 | 2010-06-29 | Medtronic, Inc. | Minimally invasive valve repair procedure and apparatus |
| US20100185172A1 (en)* | 2009-01-20 | 2010-07-22 | Mariel Fabro | Diagnostic catheters, guide catheters, visualization devices and chord manipulation devices, and related kits and methods |
| US7763040B2 (en) | 1998-06-03 | 2010-07-27 | Medtronic, Inc. | Tissue connector apparatus and methods |
| US7766812B2 (en) | 2000-10-06 | 2010-08-03 | Edwards Lifesciences Llc | Methods and devices for improving mitral valve function |
| US20100198192A1 (en)* | 2009-01-20 | 2010-08-05 | Eugene Serina | Anchor deployment devices and related methods |
| US20100211166A1 (en)* | 2009-02-17 | 2010-08-19 | Eran Miller | Actively-engageable movement-restriction mechanism for use with an annuloplasty structure |
| US20100262167A1 (en)* | 2009-04-09 | 2010-10-14 | Medtronic, Inc. | Medical Clip with Radial Tines, System and Method of Using Same |
| US20100274267A1 (en)* | 2009-04-24 | 2010-10-28 | Medtronics, Inc. | Medical Clip with Tines, System and Method of Using Same |
| US20110009641A1 (en)* | 2005-06-15 | 2011-01-13 | Anderson Daniel G | Amine-containing lipids and uses thereof |
| US7879047B2 (en) | 2003-12-10 | 2011-02-01 | Medtronic, Inc. | Surgical connection apparatus and methods |
| US7883539B2 (en) | 1997-01-02 | 2011-02-08 | Edwards Lifesciences Llc | Heart wall tension reduction apparatus and method |
| US7896892B2 (en) | 2000-03-31 | 2011-03-01 | Medtronic, Inc. | Multiple bias surgical fastener |
| WO2011033508A1 (en) | 2009-09-15 | 2011-03-24 | Transcardia Ltd. | Heart valve remodeling |
| US7938840B2 (en) | 1999-04-05 | 2011-05-10 | Medtronic, Inc. | Apparatus and methods for anastomosis |
| USRE42395E1 (en)* | 1981-10-29 | 2011-05-24 | Medtronic, Inc. | Valve holder for tricuspid heart valve |
| US7951196B2 (en) | 2004-04-29 | 2011-05-31 | Edwards Lifesciences Corporation | Annuloplasty ring for mitral valve prolapse |
| US7963973B2 (en) | 1998-06-03 | 2011-06-21 | Medtronic, Inc. | Multiple loop tissue connector apparatus and methods |
| US20110160849A1 (en)* | 2009-12-22 | 2011-06-30 | Edwards Lifesciences Corporation | Bimodal tricuspid annuloplasty ring |
| US7976556B2 (en) | 2002-09-12 | 2011-07-12 | Medtronic, Inc. | Anastomosis apparatus and methods |
| US20110184511A1 (en)* | 2010-01-22 | 2011-07-28 | Edwards Lifesciences Corporation | Tricuspid ring |
| US8029519B2 (en) | 2003-08-22 | 2011-10-04 | Medtronic, Inc. | Eversion apparatus and methods |
| US8105345B2 (en) | 2002-10-04 | 2012-01-31 | Medtronic, Inc. | Anastomosis apparatus and methods |
| US8118822B2 (en) | 1999-03-01 | 2012-02-21 | Medtronic, Inc. | Bridge clip tissue connector apparatus and methods |
| US8152844B2 (en) | 2008-05-09 | 2012-04-10 | Edwards Lifesciences Corporation | Quick-release annuloplasty ring holder |
| US8177836B2 (en) | 2008-03-10 | 2012-05-15 | Medtronic, Inc. | Apparatus and methods for minimally invasive valve repair |
| US8211124B2 (en) | 2003-07-25 | 2012-07-03 | Medtronic, Inc. | Sealing clip, delivery systems, and methods |
| US8226711B2 (en) | 1997-12-17 | 2012-07-24 | Edwards Lifesciences, Llc | Valve to myocardium tension members device and method |
| US8394114B2 (en) | 2003-09-26 | 2013-03-12 | Medtronic, Inc. | Surgical connection apparatus and methods |
| US8529583B1 (en) | 1999-09-03 | 2013-09-10 | Medtronic, Inc. | Surgical clip removal apparatus |
| US8845717B2 (en) | 2011-01-28 | 2014-09-30 | Middle Park Medical, Inc. | Coaptation enhancement implant, system, and method |
| US8888843B2 (en) | 2011-01-28 | 2014-11-18 | Middle Peak Medical, Inc. | Device, system, and method for transcatheter treatment of valve regurgitation |
| US8915960B2 (en) | 2010-08-31 | 2014-12-23 | Edwards Lifesciences Corporation | Physiologic tricuspid annuloplasty ring |
| US8920493B2 (en) | 2011-09-16 | 2014-12-30 | St. Jude Medical, Cardiology Division, Inc. | Systems and methods for holding annuloplasty rings |
| US8932350B2 (en) | 2010-11-30 | 2015-01-13 | Edwards Lifesciences Corporation | Reduced dehiscence annuloplasty ring |
| US8940044B2 (en) | 2011-06-23 | 2015-01-27 | Valtech Cardio, Ltd. | Closure element for use with an annuloplasty structure |
| US8969353B2 (en) | 2008-11-07 | 2015-03-03 | Massachusetts Institute Of Technology | Aminoalcohol lipidoids and uses thereof |
| US8992606B2 (en) | 2010-03-19 | 2015-03-31 | Xavier Ruyra Baliarda | Prosthetic device for repairing a mitral valve |
| US9011530B2 (en) | 2008-12-22 | 2015-04-21 | Valtech Cardio, Ltd. | Partially-adjustable annuloplasty structure |
| US9101472B2 (en) | 2007-09-07 | 2015-08-11 | Edwards Lifesciences Corporation | Active holder for annuloplasty ring delivery |
| US9119719B2 (en) | 2009-05-07 | 2015-09-01 | Valtech Cardio, Ltd. | Annuloplasty ring with intra-ring anchoring |
| US9155622B2 (en) | 2013-08-14 | 2015-10-13 | Sorin Group Italia S.R.L. | Apparatus and method for chordal replacement |
| US9181321B2 (en) | 2013-03-14 | 2015-11-10 | Shire Human Genetic Therapies, Inc. | CFTR mRNA compositions and related methods and uses |
| US9193827B2 (en) | 2010-08-26 | 2015-11-24 | Massachusetts Institute Of Technology | Poly(beta-amino alcohols), their preparation, and uses thereof |
| US9192472B2 (en) | 2008-06-16 | 2015-11-24 | Valtec Cardio, Ltd. | Annuloplasty devices and methods of delivery therefor |
| US9238716B2 (en) | 2011-03-28 | 2016-01-19 | Massachusetts Institute Of Technology | Conjugated lipomers and uses thereof |
| US9265608B2 (en) | 2011-11-04 | 2016-02-23 | Valtech Cardio, Ltd. | Implant having multiple rotational assemblies |
| US9308281B2 (en) | 2011-06-08 | 2016-04-12 | Shire Human Genetic Therapies, Inc. | MRNA therapy for Fabry disease |
| US9315472B2 (en) | 2013-05-01 | 2016-04-19 | Massachusetts Institute Of Technology | 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof |
| US9326858B2 (en) | 2010-08-24 | 2016-05-03 | Edwards Lifesciences Corporation | Flexible annuloplasty ring |
| US20160120643A1 (en)* | 2014-11-05 | 2016-05-05 | Tara Kupumbati | Transcatheter cardiac valve prosthetic |
| US9364322B2 (en) | 2012-12-31 | 2016-06-14 | Edwards Lifesciences Corporation | Post-implant expandable surgical heart valve configurations |
| US9414921B2 (en) | 2009-10-29 | 2016-08-16 | Valtech Cardio, Ltd. | Tissue anchor for annuloplasty device |
| US9474606B2 (en) | 2009-05-04 | 2016-10-25 | Valtech Cardio, Ltd. | Over-wire implant contraction methods |
| US9522176B2 (en) | 2013-10-22 | 2016-12-20 | Shire Human Genetic Therapies, Inc. | MRNA therapy for phenylketonuria |
| US9526613B2 (en) | 2005-03-17 | 2016-12-27 | Valtech Cardio Ltd. | Mitral valve treatment techniques |
| US9592121B1 (en) | 2015-11-06 | 2017-03-14 | Middle Peak Medical, Inc. | Device, system, and method for transcatheter treatment of valvular regurgitation |
| US9610162B2 (en) | 2013-12-26 | 2017-04-04 | Valtech Cardio, Ltd. | Implantation of flexible implant |
| US9622861B2 (en) | 2009-12-02 | 2017-04-18 | Valtech Cardio, Ltd. | Tool for actuating an adjusting mechanism |
| US9629804B2 (en) | 2013-10-22 | 2017-04-25 | Shire Human Genetic Therapies, Inc. | Lipid formulations for delivery of messenger RNA |
| US9687346B2 (en) | 2013-03-14 | 2017-06-27 | Edwards Lifesciences Corporation | Multi-stranded heat set annuloplasty rings |
| US9713530B2 (en) | 2008-12-22 | 2017-07-25 | Valtech Cardio, Ltd. | Adjustable annuloplasty devices and adjustment mechanisms therefor |
| US9724192B2 (en) | 2011-11-08 | 2017-08-08 | Valtech Cardio, Ltd. | Controlled steering functionality for implant-delivery tool |
| US20170224473A1 (en)* | 2014-10-13 | 2017-08-10 | Jack Kanouzi | Implantable prosthetic ring for correcting and preventing breast areola asymmetry |
| US20170224477A1 (en)* | 2014-10-16 | 2017-08-10 | Jacques Seguin | Intervalvular implant for a mitral valve |
| US9730793B2 (en) | 2012-12-06 | 2017-08-15 | Valtech Cardio, Ltd. | Techniques for guide-wire based advancement of a tool |
| US9840479B2 (en) | 2014-07-02 | 2017-12-12 | Massachusetts Institute Of Technology | Polyamine-fatty acid derived lipidoids and uses thereof |
| US9850269B2 (en) | 2014-04-25 | 2017-12-26 | Translate Bio, Inc. | Methods for purification of messenger RNA |
| US9861350B2 (en) | 2010-09-03 | 2018-01-09 | Ancora Heart, Inc. | Devices and methods for anchoring tissue |
| US9883943B2 (en) | 2006-12-05 | 2018-02-06 | Valtech Cardio, Ltd. | Implantation of repair devices in the heart |
| US9949829B2 (en) | 2002-06-13 | 2018-04-24 | Ancora Heart, Inc. | Delivery devices and methods for heart valve repair |
| US9949828B2 (en) | 2012-10-23 | 2018-04-24 | Valtech Cardio, Ltd. | Controlled steering functionality for implant-delivery tool |
| US9957499B2 (en) | 2013-03-14 | 2018-05-01 | Translate Bio, Inc. | Methods for purification of messenger RNA |
| US9968454B2 (en) | 2009-10-29 | 2018-05-15 | Valtech Cardio, Ltd. | Techniques for guide-wire based advancement of artificial chordae |
| US9968452B2 (en) | 2009-05-04 | 2018-05-15 | Valtech Cardio, Ltd. | Annuloplasty ring delivery cathethers |
| US10022455B2 (en) | 2014-05-30 | 2018-07-17 | Translate Bio, Inc. | Biodegradable lipids for delivery of nucleic acids |
| US10039531B2 (en) | 2005-12-15 | 2018-08-07 | Georgia Tech Research Corporation | Systems and methods to control the dimension of a heart valve |
| US10058321B2 (en) | 2015-03-05 | 2018-08-28 | Ancora Heart, Inc. | Devices and methods of visualizing and determining depth of penetration in cardiac tissue |
| US10098737B2 (en) | 2009-10-29 | 2018-10-16 | Valtech Cardio, Ltd. | Tissue anchor for annuloplasty device |
| US10111663B2 (en) | 2011-02-18 | 2018-10-30 | Ancora Heart, Inc. | Implant retrieval device |
| US10123874B2 (en) | 2017-03-13 | 2018-11-13 | Middle Peak Medical, Inc. | Device, system, and method for transcatheter treatment of valvular regurgitation |
| US10138213B2 (en) | 2014-06-24 | 2018-11-27 | Translate Bio, Inc. | Stereochemically enriched compositions for delivery of nucleic acids |
| US10166098B2 (en) | 2013-10-25 | 2019-01-01 | Middle Peak Medical, Inc. | Systems and methods for transcatheter treatment of valve regurgitation |
| US10195029B2 (en) | 2005-09-07 | 2019-02-05 | Medtentia Internatinal Ltd Oy | Device and method for improving the function of a heart valve |
| US10195030B2 (en) | 2014-10-14 | 2019-02-05 | Valtech Cardio, Ltd. | Leaflet-restraining techniques |
| US10226342B2 (en) | 2016-07-08 | 2019-03-12 | Valtech Cardio, Ltd. | Adjustable annuloplasty device with alternating peaks and troughs |
| US10231831B2 (en) | 2009-12-08 | 2019-03-19 | Cardiovalve Ltd. | Folding ring implant for heart valve |
| US10251635B2 (en) | 2014-06-24 | 2019-04-09 | Middle Peak Medical, Inc. | Systems and methods for anchoring an implant |
| US10299793B2 (en) | 2013-10-23 | 2019-05-28 | Valtech Cardio, Ltd. | Anchor magazine |
| US10314707B2 (en) | 2015-06-09 | 2019-06-11 | Edwards Lifesciences, Llc | Asymmetric mitral annuloplasty band |
| US10376266B2 (en) | 2012-10-23 | 2019-08-13 | Valtech Cardio, Ltd. | Percutaneous tissue anchor techniques |
| US10449333B2 (en) | 2013-03-14 | 2019-10-22 | Valtech Cardio, Ltd. | Guidewire feeder |
| US10456246B2 (en) | 2015-07-02 | 2019-10-29 | Edwards Lifesciences Corporation | Integrated hybrid heart valves |
| US10470882B2 (en) | 2008-12-22 | 2019-11-12 | Valtech Cardio, Ltd. | Closure element for use with annuloplasty structure |
| US10478303B2 (en) | 2017-03-13 | 2019-11-19 | Polares Medical Inc. | Device, system, and method for transcatheter treatment of valvular regurgitation |
| US10500048B2 (en) | 2014-06-18 | 2019-12-10 | Polares Medical Inc. | Mitral valve implants for the treatment of valvular regurgitation |
| US10517719B2 (en) | 2008-12-22 | 2019-12-31 | Valtech Cardio, Ltd. | Implantation of repair devices in the heart |
| US10543085B2 (en) | 2012-12-31 | 2020-01-28 | Edwards Lifesciences Corporation | One-piece heart valve stents adapted for post-implant expansion |
| US10576166B2 (en) | 2009-12-01 | 2020-03-03 | Translate Bio, Inc. | Liver specific delivery of messenger RNA |
| US10653524B2 (en) | 2017-03-13 | 2020-05-19 | Polares Medical Inc. | Device, system, and method for transcatheter treatment of valvular regurgitation |
| US10667914B2 (en) | 2016-11-18 | 2020-06-02 | Ancora Heart, Inc. | Myocardial implant load sharing device and methods to promote LV function |
| US10682232B2 (en) | 2013-03-15 | 2020-06-16 | Edwards Lifesciences Corporation | Translation catheters, systems, and methods of use thereof |
| US10695170B2 (en) | 2015-07-02 | 2020-06-30 | Edwards Lifesciences Corporation | Hybrid heart valves adapted for post-implant expansion |
| US10695046B2 (en) | 2005-07-05 | 2020-06-30 | Edwards Lifesciences Corporation | Tissue anchor and anchoring system |
| US10702274B2 (en) | 2016-05-26 | 2020-07-07 | Edwards Lifesciences Corporation | Method and system for closing left atrial appendage |
| US10709449B2 (en) | 2011-02-18 | 2020-07-14 | Ancora Heart, Inc. | Systems and methods for variable stiffness tethers |
| US10722356B2 (en) | 2016-11-03 | 2020-07-28 | Edwards Lifesciences Corporation | Prosthetic mitral valve holders |
| US10751182B2 (en) | 2015-12-30 | 2020-08-25 | Edwards Lifesciences Corporation | System and method for reshaping right heart |
| US10765514B2 (en) | 2015-04-30 | 2020-09-08 | Valtech Cardio, Ltd. | Annuloplasty technologies |
| US10792152B2 (en) | 2011-06-23 | 2020-10-06 | Valtech Cardio, Ltd. | Closed band for percutaneous annuloplasty |
| US10828160B2 (en) | 2015-12-30 | 2020-11-10 | Edwards Lifesciences Corporation | System and method for reducing tricuspid regurgitation |
| US10835221B2 (en) | 2017-11-02 | 2020-11-17 | Valtech Cardio, Ltd. | Implant-cinching devices and systems |
| US10918373B2 (en) | 2013-08-31 | 2021-02-16 | Edwards Lifesciences Corporation | Devices and methods for locating and implanting tissue anchors at mitral valve commissure |
| US10918374B2 (en) | 2013-02-26 | 2021-02-16 | Edwards Lifesciences Corporation | Devices and methods for percutaneous tricuspid valve repair |
| US10925610B2 (en) | 2015-03-05 | 2021-02-23 | Edwards Lifesciences Corporation | Devices for treating paravalvular leakage and methods use thereof |
| US10980973B2 (en) | 2015-05-12 | 2021-04-20 | Ancora Heart, Inc. | Device and method for releasing catheters from cardiac structures |
| US11045627B2 (en) | 2017-04-18 | 2021-06-29 | Edwards Lifesciences Corporation | Catheter system with linear actuation control mechanism |
| US11123191B2 (en) | 2018-07-12 | 2021-09-21 | Valtech Cardio Ltd. | Annuloplasty systems and locking tools therefor |
| US11135062B2 (en) | 2017-11-20 | 2021-10-05 | Valtech Cardio Ltd. | Cinching of dilated heart muscle |
| US11173190B2 (en) | 2017-05-16 | 2021-11-16 | Translate Bio, Inc. | Treatment of cystic fibrosis by delivery of codon-optimized mRNA encoding CFTR |
| US11174500B2 (en) | 2018-08-24 | 2021-11-16 | Translate Bio, Inc. | Methods for purification of messenger RNA |
| US11224642B2 (en) | 2013-10-22 | 2022-01-18 | Translate Bio, Inc. | MRNA therapy for argininosuccinate synthetase deficiency |
| US11253605B2 (en) | 2017-02-27 | 2022-02-22 | Translate Bio, Inc. | Codon-optimized CFTR MRNA |
| USD944398S1 (en) | 2018-06-13 | 2022-02-22 | Edwards Lifesciences Corporation | Expanded heart valve stent |
| US11254936B2 (en) | 2012-06-08 | 2022-02-22 | Translate Bio, Inc. | Nuclease resistant polynucleotides and uses thereof |
| US11259924B2 (en) | 2006-12-05 | 2022-03-01 | Valtech Cardio Ltd. | Implantation of repair devices in the heart |
| US11395648B2 (en) | 2012-09-29 | 2022-07-26 | Edwards Lifesciences Corporation | Plication lock delivery system and method of use thereof |
| US11464634B2 (en) | 2020-12-16 | 2022-10-11 | Polares Medical Inc. | Device, system, and method for transcatheter treatment of valvular regurgitation with secondary anchors |
| US11554015B2 (en) | 2018-07-30 | 2023-01-17 | Edwards Lifesciences Corporation | Minimally-invasive low strain annuloplasty ring |
| US11554012B2 (en) | 2019-12-16 | 2023-01-17 | Edwards Lifesciences Corporation | Valve holder assembly with suture looping protection |
| US11653910B2 (en) | 2010-07-21 | 2023-05-23 | Cardiovalve Ltd. | Helical anchor implantation |
| US11660190B2 (en) | 2007-03-13 | 2023-05-30 | Edwards Lifesciences Corporation | Tissue anchors, systems and methods, and devices |
| US11660191B2 (en) | 2008-03-10 | 2023-05-30 | Edwards Lifesciences Corporation | Method to reduce mitral regurgitation |
| US11666442B2 (en) | 2018-01-26 | 2023-06-06 | Edwards Lifesciences Innovation (Israel) Ltd. | Techniques for facilitating heart valve tethering and chord replacement |
| US11672524B2 (en) | 2019-07-15 | 2023-06-13 | Ancora Heart, Inc. | Devices and methods for tether cutting |
| US11759321B2 (en) | 2021-06-25 | 2023-09-19 | Polares Medical Inc. | Device, system, and method for transcatheter treatment of valvular regurgitation |
| US11779458B2 (en) | 2016-08-10 | 2023-10-10 | Cardiovalve Ltd. | Prosthetic valve with leaflet connectors |
| US11779463B2 (en) | 2018-01-24 | 2023-10-10 | Edwards Lifesciences Innovation (Israel) Ltd. | Contraction of an annuloplasty structure |
| US11801135B2 (en) | 2015-02-05 | 2023-10-31 | Cardiovalve Ltd. | Techniques for deployment of a prosthetic valve |
| US11819411B2 (en) | 2019-10-29 | 2023-11-21 | Edwards Lifesciences Innovation (Israel) Ltd. | Annuloplasty and tissue anchor technologies |
| US11844691B2 (en) | 2013-01-24 | 2023-12-19 | Cardiovalve Ltd. | Partially-covered prosthetic valves |
| US11937795B2 (en) | 2016-02-16 | 2024-03-26 | Cardiovalve Ltd. | Techniques for providing a replacement valve and transseptal communication |
| US11969348B2 (en) | 2011-12-12 | 2024-04-30 | Edwards Lifesciences Corporation | Cardiac valve replacement |
| US12023247B2 (en) | 2020-05-20 | 2024-07-02 | Edwards Lifesciences Corporation | Reducing the diameter of a cardiac valve annulus with independent control over each of the anchors that are launched into the annulus |
| US12029646B2 (en) | 2017-08-03 | 2024-07-09 | Cardiovalve Ltd. | Prosthetic heart valve |
| US12035898B2 (en) | 2005-04-22 | 2024-07-16 | Edwards Lifesciences Corporation | Catheter-based tissue remodeling devices and methods |
| US12053379B2 (en) | 2016-08-01 | 2024-08-06 | Cardiovalve Ltd. | Minimally-invasive delivery systems |
| US12053380B2 (en) | 2014-07-30 | 2024-08-06 | Cardiovalve Ltd. | Anchoring of a prosthetic valve |
| US12090048B2 (en) | 2017-08-03 | 2024-09-17 | Cardiovalve Ltd. | Prosthetic heart valve |
| US12138165B2 (en) | 2011-06-23 | 2024-11-12 | Edwards Lifesciences Innovation (Israel) Ltd. | Annuloplasty implants |
| US12195505B2 (en) | 2018-11-21 | 2025-01-14 | Translate Bio, Inc. | Treatment of cystic fibrosis by delivery of nebulized mRNA encoding CFTR |
| US12208006B2 (en) | 2019-09-25 | 2025-01-28 | Edwards Lifesciences Corporation | Constricting a cardiac valve annulus using a cord that has a loop portion and a single second portion |
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| US12357459B2 (en) | 2020-12-03 | 2025-07-15 | Cardiovalve Ltd. | Transluminal delivery system |
| US12364606B2 (en) | 2019-07-23 | 2025-07-22 | Edwards Lifesciences Innovation (Israel) Ltd. | Fluoroscopic visualization of heart valve anatomy |
| US12396718B2 (en) | 2020-06-19 | 2025-08-26 | Edwards Lifesciences Corporation | Self-stopping tissue anchors |
| US12419749B2 (en) | 2019-08-30 | 2025-09-23 | Edwards Lifesciences Innovation (Israel) Ltd. | Anchor channel tip |
| US12440330B2 (en) | 2023-08-04 | 2025-10-14 | Edwards Lifesciences Corporation | Prosthetic mitral valve holders |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5435037Y2 (en)* | 1975-10-29 | 1979-10-25 | ||
| DE3230858C2 (en)* | 1982-08-19 | 1985-01-24 | Ahmadi, Ali, Dr. med., 7809 Denzlingen | Ring prosthesis |
| JPH05184611A (en)* | 1991-03-19 | 1993-07-27 | Kenji Kusuhara | Valvular annulation retaining member and its attaching method |
| FR2688692A1 (en)* | 1992-03-20 | 1993-09-24 | Seguin Jacques | Prosthetic ring for reconstruction surgery of the aortic valve |
| FR2891134B1 (en)* | 2005-09-29 | 2008-08-22 | Jean Noel Fabiani | ANNULAR PROSTHESIS FOR AORTIC VALVULAR PLASTIC, METHOD FOR AORTIC VALVULAR PLASTIC AND COMBINATION OF ANNULAR PROSTHESIS AND PROSTHESIS FOR AORTIC SEGMENT |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3396409A (en)* | 1964-12-31 | 1968-08-13 | Nat Res Dev | Artificial heart valve |
- 1970
- 1970-01-27NLNL707001136Apatent/NL143127B/ennot_activeIP Right Cessation
- 1970-02-02CSCS724Apatent/CS163762B2/csunknown
- 1970-02-03LULU60294Dpatent/LU60294A1/xxunknown
- 1970-02-03BEBE745427Dpatent/BE745427A/ennot_activeIP Right Cessation
- 1970-02-03ILIL33838Apatent/IL33838A/enunknown
- 1970-02-03NONO0378/70Apatent/NO123299B/nounknown
- 1970-02-03CHCH154370Apatent/CH508395A/ennot_activeIP Right Cessation
- 1970-02-03SESE01359/70Apatent/SE357140B/xxunknown
- 1970-02-03GBGB5171/70Apatent/GB1293014A/ennot_activeExpired
- 1970-02-03CACA073881Apatent/CA930503A/ennot_activeExpired
- 1970-02-04USUS8564Apatent/US3656185A/ennot_activeExpired - Lifetime
- 1970-02-04DEDE2005112Apatent/DE2005112C3/ennot_activeExpired
- 1970-02-04SUSU1401065Apatent/SU365053A3/ruactive
- 1970-02-04JPJP45009354Apatent/JPS504999B1/jaactivePending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3396409A (en)* | 1964-12-31 | 1968-08-13 | Nat Res Dev | Artificial heart valve |
Non-Patent Citations (3)
| Title |
|---|
| A Prosthetic Stented Aortic Homograft For Mitral Valve Replacement by C. S. Weldon et al., Journal of Surgical Research, Vol. 6, No. 12, Dec. 1966, pgs. 548 552* |
| Simplified Insertion of Aortic Homograft Valves With Nonthrombogenic Prosthetic Frames by Nina S. Braunwald et al., Transaction American Soc. For Artificial Internal Organs, vol. XIII, 1967, pgs. 111 113* |
| The In Vivo Comparison of Hemodynamic Function of Ball, Disk, and Eccentric Monocusp Artifial Mitral Valves by R. W. M. Frater et al., Prosthetic Heart Valves, Charles C. Thomas Publisher, Springfield, Illinois, 1968, pgs. 262 266* |
Cited By (694)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3908201A (en)* | 1972-06-30 | 1975-09-30 | Ici Ltd | Prosthetics |
| US4042978A (en)* | 1972-06-30 | 1977-08-23 | Imperial Chemical Industries Limited | Prosthetics |
| US4055861A (en)* | 1975-04-11 | 1977-11-01 | Rhone-Poulenc Industries | Support for a natural human heart valve |
| US4217665A (en)* | 1975-06-23 | 1980-08-19 | Societe D'utilisation Scientifique Et Industrielle Du Froid - Usifroid | Prosthesis for use in valvuloplasty |
| US4042979A (en)* | 1976-07-12 | 1977-08-23 | Angell William W | Valvuloplasty ring and prosthetic method |
| US4204283A (en)* | 1977-05-05 | 1980-05-27 | National Research Development Corporation | Prosthetic valve |
| US4164046A (en)* | 1977-05-16 | 1979-08-14 | Cooley Denton | Valve prosthesis |
| US4290151A (en)* | 1979-07-31 | 1981-09-22 | Massana Miguel P | Adjustable annular prosthesis for cardiac surgery |
| US4865600A (en)* | 1981-08-25 | 1989-09-12 | Baxter International Inc. | Mitral valve holder |
| USRE42395E1 (en)* | 1981-10-29 | 2011-05-24 | Medtronic, Inc. | Valve holder for tricuspid heart valve |
| US4489446A (en)* | 1982-07-14 | 1984-12-25 | Reed Charles C | Heart valve prosthesis |
| US5061277A (en)* | 1986-08-06 | 1991-10-29 | Baxter International Inc. | Flexible cardiac valvular support prosthesis |
| EP0338994A1 (en)* | 1988-01-12 | 1989-10-25 | Mario Morea | Prosthetic device for the surgical correction of tricuspid insufficiency |
| US4917698A (en)* | 1988-12-22 | 1990-04-17 | Baxter International Inc. | Multi-segmented annuloplasty ring prosthesis |
| US5104407A (en)* | 1989-02-13 | 1992-04-14 | Baxter International Inc. | Selectively flexible annuloplasty ring |
| US20050027352A1 (en)* | 1989-07-31 | 2005-02-03 | Cosgrove Delos M. | Annuloplasty ring delivery system and method |
| US6558416B2 (en) | 1989-07-31 | 2003-05-06 | Edwards Lifesciences Corporation | Annuloplasty ring delivery method |
| US5350420A (en)* | 1989-07-31 | 1994-09-27 | Baxter International Inc. | Flexible annuloplasty ring and holder |
| US20030195619A1 (en)* | 1989-07-31 | 2003-10-16 | Cosgrove Delos M. | Annuloplasty ring delivery system |
| US6283993B1 (en) | 1989-07-31 | 2001-09-04 | Edwards Lifesciences Corporation | Annuloplasty ring delivery system |
| US6802860B2 (en) | 1989-07-31 | 2004-10-12 | Edwards Lifesciences Corporation | Annuloplasty ring delivery system |
| US5041130A (en)* | 1989-07-31 | 1991-08-20 | Baxter International Inc. | Flexible annuloplasty ring and holder |
| WO1991019465A1 (en)* | 1990-06-07 | 1991-12-26 | Robert William Mayo Frater | Mitral heart valve replacements |
| US5415667A (en)* | 1990-06-07 | 1995-05-16 | Frater; Robert W. M. | Mitral heart valve replacements |
| US5674279A (en)* | 1992-01-27 | 1997-10-07 | Medtronic, Inc. | Annuloplasty and suture rings |
| US5258023A (en)* | 1992-02-12 | 1993-11-02 | Reger Medical Development, Inc. | Prosthetic heart valve |
| US5607471A (en)* | 1993-08-03 | 1997-03-04 | Jacques Seguin | Prosthetic ring for heart surgery |
| FR2708458A1 (en)* | 1993-08-03 | 1995-02-10 | Seguin Jacques | Prosthetic ring for cardiac surgery. |
| WO1995003757A1 (en)* | 1993-08-03 | 1995-02-09 | Jacques Seguin | Prosthetic ring for use in cardiac surgery |
| WO1995006447A1 (en)* | 1993-08-31 | 1995-03-09 | W.L. Gore & Associates, Inc. | Improved device for tissue repair and method for employing same |
| US5562729A (en)* | 1994-11-01 | 1996-10-08 | Biocontrol Technology, Inc. | Heart valve |
| US5824066A (en)* | 1995-12-01 | 1998-10-20 | Medtronic, Inc. | Annuloplasty prosthesis |
| US20090137863A1 (en)* | 1997-01-02 | 2009-05-28 | Myocor, Inc. | Heart wall tension reduction apparatus |
| US20020077524A1 (en)* | 1997-01-02 | 2002-06-20 | Myocor, Inc. | Heart wall tension reduction apparatus |
| US8267852B2 (en) | 1997-01-02 | 2012-09-18 | Edwards Lifesciences, Llc | Heart wall tension reduction apparatus and method |
| US20040167374A1 (en)* | 1997-01-02 | 2004-08-26 | Myocor, Inc. | Heart wall tension reduction apparatus and method |
| US8460173B2 (en) | 1997-01-02 | 2013-06-11 | Edwards Lifesciences, Llc | Heart wall tension reduction apparatus and method |
| US7695425B2 (en) | 1997-01-02 | 2010-04-13 | Edwards Lifesciences Llc | Heart wall tension reduction apparatus and method |
| US7883539B2 (en) | 1997-01-02 | 2011-02-08 | Edwards Lifesciences Llc | Heart wall tension reduction apparatus and method |
| US20070112244A1 (en)* | 1997-01-02 | 2007-05-17 | Myocor, Inc. | Methods and devices for improving cardiac function in hearts |
| US7189199B2 (en) | 1997-01-02 | 2007-03-13 | Myocor, Inc. | Methods and devices for improving cardiac function in hearts |
| US20020169359A1 (en)* | 1997-01-02 | 2002-11-14 | Myocor, Inc. | Methods and devices for improving cardiac function in hearts |
| US5776189A (en)* | 1997-03-05 | 1998-07-07 | Khalid; Naqeeb | Cardiac valvular support prosthesis |
| WO1999029269A1 (en)* | 1997-12-05 | 1999-06-17 | St. Jude Medical, Inc. | Annuloplasty ring with cut zone |
| US6174332B1 (en) | 1997-12-05 | 2001-01-16 | St. Jude Medical, Inc. | Annuloplasty ring with cut zone |
| US8226711B2 (en) | 1997-12-17 | 2012-07-24 | Edwards Lifesciences, Llc | Valve to myocardium tension members device and method |
| US7275546B2 (en) | 1998-05-01 | 2007-10-02 | Buckberg Gerald D | Anterior and inferior segment ventricular restoration apparatus and method |
| US6837247B2 (en) | 1998-05-01 | 2005-01-04 | Correstore, Inc. | Method of using ventricular restoration patch |
| US7758494B2 (en) | 1998-05-01 | 2010-07-20 | Correstore, Inc. | Anterior segment ventricular restoration apparatus and method |
| US6450171B1 (en) | 1998-05-01 | 2002-09-17 | Correstore, Inc. | Anterior and inferior segment ventricular restoration apparatus and method |
| US20020198603A1 (en)* | 1998-05-01 | 2002-12-26 | Correstore, Inc. | Anterior segment ventricular restoration apparatus and method |
| US7914438B2 (en) | 1998-05-01 | 2011-03-29 | Correstore Llc | Ventricular restoration patch |
| US6544167B2 (en) | 1998-05-01 | 2003-04-08 | Correstore, Inc. | Ventricular restoration patch |
| US6024096A (en)* | 1998-05-01 | 2000-02-15 | Correstore Inc | Anterior segment ventricular restoration apparatus and method |
| US20060258900A1 (en)* | 1998-05-01 | 2006-11-16 | Buckberg Gerald D | Anterior Segment Ventricular Restoration Apparatus and Method |
| US6439237B1 (en) | 1998-05-01 | 2002-08-27 | Correstore, Inc. | Anterior segment coronary restoration apparatus and method |
| US7056280B2 (en) | 1998-05-01 | 2006-06-06 | Correstore, Inc. | Anterior segment ventricular restoration apparatus and method |
| US7594886B2 (en) | 1998-05-01 | 2009-09-29 | Correstore Llc | Method of using ventricular restoration patch |
| US6221104B1 (en) | 1998-05-01 | 2001-04-24 | Cor Restore, Inc. | Anterior and interior segment cardiac restoration apparatus and method |
| US20050119520A1 (en)* | 1998-05-01 | 2005-06-02 | Buckberg Gerald D. | Method of using ventricular restoration patch |
| US20100081869A1 (en)* | 1998-05-01 | 2010-04-01 | Buckberg Gerald D | Ventricular Restoration Patch |
| US20030191538A1 (en)* | 1998-05-01 | 2003-10-09 | Buckberg Gerald D. | Method of using ventricular restoration patch |
| US7547313B2 (en) | 1998-06-03 | 2009-06-16 | Medtronic, Inc. | Tissue connector apparatus and methods |
| US7963973B2 (en) | 1998-06-03 | 2011-06-21 | Medtronic, Inc. | Multiple loop tissue connector apparatus and methods |
| US7763040B2 (en) | 1998-06-03 | 2010-07-27 | Medtronic, Inc. | Tissue connector apparatus and methods |
| US6143024A (en)* | 1998-06-04 | 2000-11-07 | Sulzer Carbomedics Inc. | Annuloplasty ring having flexible anterior portion |
| US6254636B1 (en) | 1998-06-26 | 2001-07-03 | St. Jude Medical, Inc. | Single suture biological tissue aortic stentless valve |
| US6558417B2 (en) | 1998-06-26 | 2003-05-06 | St. Jude Medical, Inc. | Single suture biological tissue aortic stentless valve |
| US7981020B2 (en) | 1998-07-29 | 2011-07-19 | Edwards Lifesciences Llc | Transventricular implant tools and devices |
| US7722523B2 (en) | 1998-07-29 | 2010-05-25 | Edwards Lifesciences Llc | Transventricular implant tools and devices |
| US20080319256A1 (en)* | 1998-07-29 | 2008-12-25 | Myocor, Inc. | Transventricular implant tools and devices |
| US8579798B2 (en) | 1998-09-21 | 2013-11-12 | Edwards Lifesciences, Llc | External cardiac stress reduction method |
| US20050065396A1 (en)* | 1998-09-21 | 2005-03-24 | Myocor, Inc. | External stress reduction device and method |
| US6102945A (en)* | 1998-10-16 | 2000-08-15 | Sulzer Carbomedics, Inc. | Separable annuloplasty ring |
| US20100161046A1 (en)* | 1999-01-26 | 2010-06-24 | Edwards Lifesciences Corporation | Holder for flexible heart valve |
| US7993393B2 (en) | 1999-01-26 | 2011-08-09 | Edwards Lifesciences Corporation | Flexible heart valve and associated connecting band |
| US8118822B2 (en) | 1999-03-01 | 2012-02-21 | Medtronic, Inc. | Bridge clip tissue connector apparatus and methods |
| US7892255B2 (en) | 1999-03-01 | 2011-02-22 | Medtronic, Inc. | Tissue connector apparatus and methods |
| US8353921B2 (en) | 1999-03-01 | 2013-01-15 | Medtronic, Inc | Tissue connector apparatus and methods |
| US7722643B2 (en) | 1999-03-01 | 2010-05-25 | Medtronic, Inc. | Tissue connector apparatus and methods |
| US7938840B2 (en) | 1999-04-05 | 2011-05-10 | Medtronic, Inc. | Apparatus and methods for anastomosis |
| US8211131B2 (en) | 1999-04-05 | 2012-07-03 | Medtronic, Inc. | Apparatus and methods for anastomosis |
| US6689163B2 (en) | 1999-04-08 | 2004-02-10 | Carbomedics Inc. | Annuloplasty ring holder |
| US6406492B1 (en) | 1999-04-08 | 2002-06-18 | Sulzer Carbomedics Inc. | Annuloplasty ring holder |
| WO2000062715A1 (en) | 1999-04-16 | 2000-10-26 | Edwards Lifesciences Corporation | Aortic annuloplasty ring |
| US6231602B1 (en) | 1999-04-16 | 2001-05-15 | Edwards Lifesciences Corporation | Aortic annuloplasty ring |
| US6312464B1 (en) | 1999-04-28 | 2001-11-06 | NAVIA JOSé L. | Method of implanting a stentless cardiac valve prosthesis |
| US6602289B1 (en)* | 1999-06-08 | 2003-08-05 | S&A Rings, Llc | Annuloplasty rings of particular use in surgery for the mitral valve |
| WO2000074603A1 (en)* | 1999-06-08 | 2000-12-14 | S & A Rings, Llc | Annuloplasty rings for heart valve replacement and repair |
| US6348068B1 (en) | 1999-07-23 | 2002-02-19 | Sulzer Carbomedics Inc. | Multi-filament valve stent for a cardisc valvular prosthesis |
| US8529583B1 (en) | 1999-09-03 | 2013-09-10 | Medtronic, Inc. | Surgical clip removal apparatus |
| US6306133B1 (en) | 1999-10-02 | 2001-10-23 | Quantum Cor Incorporated | Ablation catheter system and methods for repairing a valvular annulus |
| US8328798B2 (en) | 1999-10-02 | 2012-12-11 | Quantumcor, Inc | Method for treating and repairing mitral valve annulus |
| US6485489B2 (en) | 1999-10-02 | 2002-11-26 | Quantum Cor, Inc. | Catheter system for repairing a mitral valve annulus |
| US7229469B1 (en) | 1999-10-02 | 2007-06-12 | Quantumcor, Inc. | Methods for treating and repairing mitral valve annulus |
| US20030069570A1 (en)* | 1999-10-02 | 2003-04-10 | Witzel Thomas H. | Methods for repairing mitral valve annulus percutaneously |
| US7896892B2 (en) | 2000-03-31 | 2011-03-01 | Medtronic, Inc. | Multiple bias surgical fastener |
| US6569198B1 (en) | 2000-03-31 | 2003-05-27 | Richard A. Wilson | Mitral or tricuspid valve annuloplasty prosthetic device |
| US8353092B2 (en) | 2000-03-31 | 2013-01-15 | Medtronic, Inc. | Multiple bias surgical fastener |
| US6964684B2 (en) | 2000-07-06 | 2005-11-15 | Medtentia | Annuloplasty devices and related heart valve repair methods |
| US6730121B2 (en) | 2000-07-06 | 2004-05-04 | Medtentia | Annuloplasty devices and related heart valve repair methods |
| US7077861B2 (en) | 2000-07-06 | 2006-07-18 | Medtentia Ab | Annuloplasty instrument |
| US20050149178A1 (en)* | 2000-07-06 | 2005-07-07 | Medtentia Ab | Annuloplasty instrument |
| US20040167620A1 (en)* | 2000-07-06 | 2004-08-26 | Medtentia | Annuloplasty devices and related heart valve repair methods |
| US6524338B1 (en) | 2000-08-25 | 2003-02-25 | Steven R. Gundry | Method and apparatus for stapling an annuloplasty band in-situ |
| WO2002015798A2 (en) | 2000-08-25 | 2002-02-28 | Sulzer Carbomedics Inc. | Method and apparatus for stapling an annuloplasty band in-situ |
| US20070055303A1 (en)* | 2000-10-06 | 2007-03-08 | Myocor, Inc. | Endovascular splinting devices and methods |
| US7766812B2 (en) | 2000-10-06 | 2010-08-03 | Edwards Lifesciences Llc | Methods and devices for improving mitral valve function |
| US9198757B2 (en) | 2000-10-06 | 2015-12-01 | Edwards Lifesciences, Llc | Methods and devices for improving mitral valve function |
| US7914544B2 (en) | 2000-10-10 | 2011-03-29 | Medtronic, Inc. | Minimally invasive valve repair procedure and apparatus |
| US20030074012A1 (en)* | 2000-10-10 | 2003-04-17 | Coalescent Surgical, Inc. | Minimally invasive annuloplasty procedure and apparatus |
| US7744611B2 (en) | 2000-10-10 | 2010-06-29 | Medtronic, Inc. | Minimally invasive valve repair procedure and apparatus |
| US6921407B2 (en) | 2000-10-10 | 2005-07-26 | Medtronic, Inc. | Minimally invasive annuloplasty procedure and apparatus |
| US6918917B1 (en) | 2000-10-10 | 2005-07-19 | Medtronic, Inc. | Minimally invasive annuloplasty procedure and apparatus |
| US6669725B2 (en) | 2000-12-28 | 2003-12-30 | Centerpulse Biologics Inc. | Annuloplasty ring for regeneration of diseased or damaged heart valve annulus |
| US20050021135A1 (en)* | 2001-03-15 | 2005-01-27 | Ryan Timothy R. | Annuloplasty band and method |
| US20060025856A1 (en)* | 2001-03-15 | 2006-02-02 | Medtronic, Inc. | Annuloplasty band and method |
| US7371259B2 (en) | 2001-03-15 | 2008-05-13 | Medtronic, Inc. | Annuloplasty band and method |
| US7377940B2 (en) | 2001-03-15 | 2008-05-27 | Medtronic, Inc. | Implantable prosthesis |
| US7935145B2 (en)* | 2001-05-17 | 2011-05-03 | Edwards Lifesciences Corporation | Annuloplasty ring for ischemic mitral valve insuffuciency |
| US20120172983A1 (en)* | 2001-05-17 | 2012-07-05 | Edwards Lifesciences Corporation | Methods of repairing an abnormal mitral valve |
| US20110301704A1 (en)* | 2001-05-17 | 2011-12-08 | Edwards Lifesciences Corporation | Annuloplasty Rings for Repair of Abnormal Mitral Valves |
| US20050131533A1 (en)* | 2001-05-17 | 2005-06-16 | Ottavio Alfieri | Annuloplasty rings for repair of abnormal mitral valves |
| US10166101B2 (en)* | 2001-05-17 | 2019-01-01 | Edwards Lifesciences Corporation | Methods for repairing mitral valves |
| US8529621B2 (en)* | 2001-05-17 | 2013-09-10 | Edwards Lifesciences Corporation | Methods of repairing an abnormal mitral valve |
| US20100137980A1 (en)* | 2001-05-17 | 2010-06-03 | Edwards Lifesciences Corporation | Annular Prosthesis for a Mitral Valve |
| EP1266641A1 (en) | 2001-06-11 | 2002-12-18 | SORIN BIOMEDICA CARDIO S.p.A. | An annuloplasty prosthesis and a method for its manufacture |
| US20020188350A1 (en)* | 2001-06-11 | 2002-12-12 | Pietro Arru | Annuloplasty prosthesis and a method for its manufacture |
| US20050043791A1 (en)* | 2001-08-28 | 2005-02-24 | Mccarthy Patrick M. | Three-dimensional annuloplasty ring and template |
| US9149359B2 (en)* | 2001-08-28 | 2015-10-06 | Edwards Lifesciences Corporation | Three-dimensional annuloplasty ring |
| US10188518B2 (en)* | 2001-08-28 | 2019-01-29 | Edwards Lifesciences Corporation | Annuloplasty ring with variable cross-section |
| US20050182487A1 (en)* | 2001-08-28 | 2005-08-18 | Mccarthy Patrick M. | Three-dimensional annuloplasty ring and template |
| US6908482B2 (en) | 2001-08-28 | 2005-06-21 | Edwards Lifesciences Corporation | Three-dimensional annuloplasty ring and template |
| US20160354206A1 (en)* | 2001-08-28 | 2016-12-08 | Edwards Lifesciences Corporation | Annuloplasty ring with variable cross-section |
| US9414922B2 (en) | 2001-08-28 | 2016-08-16 | Edwards Lifesciences Corporation | Three-dimensional annuloplasty ring |
| US20080208331A1 (en)* | 2001-08-28 | 2008-08-28 | Edwards Lifesciences Corporation | Annuloplasty ring with offset free ends |
| US8114155B2 (en) | 2001-08-28 | 2012-02-14 | Edwards Lifesciences Corporation | Annuloplasty ring with offset free ends |
| US20030208264A1 (en)* | 2001-08-28 | 2003-11-06 | Mccarthy Patrick M. | Three-dimensional annuloplasty ring and template |
| US7367991B2 (en) | 2001-08-28 | 2008-05-06 | Edwards Lifesciences Corporation | Conformal tricuspid annuloplasty ring and template |
| US8123800B2 (en) | 2001-08-28 | 2012-02-28 | Edwards Lifesciences Corporation | Three-dimensional annuloplasty ring and template |
| US20120143321A1 (en)* | 2001-08-28 | 2012-06-07 | Edwards Lifesciences Corporation | Three-dimensional annuloplasty ring |
| US6749630B2 (en) | 2001-08-28 | 2004-06-15 | Edwards Lifesciences Corporation | Tricuspid ring and template |
| US20080215074A1 (en)* | 2001-09-07 | 2008-09-04 | Raman Jaishankar | Method and apparatus for external stabilization of the heart |
| US20090024213A1 (en)* | 2001-09-07 | 2009-01-22 | Mardil, Inc. | Method and Apparatus for External Stabilization of the Heart Valves and Myocardium |
| US8092367B2 (en) | 2001-09-07 | 2012-01-10 | Mardil, Inc. | Method for external stabilization of the base of the heart |
| US20070129598A1 (en)* | 2001-09-07 | 2007-06-07 | Raman Jaishanker | Method and apparatus for external stabilization of the heart |
| US8715160B2 (en) | 2001-09-07 | 2014-05-06 | Mardil, Inc. | Method and apparatus for external stabilization of the heart |
| US8128553B2 (en) | 2001-09-07 | 2012-03-06 | Mardil, Inc. | Method and apparatus for external stabilization of the heart |
| US9289298B2 (en) | 2001-09-07 | 2016-03-22 | Mardil, Inc. | Method and apparatus for external stabilization of the heart |
| US8236050B2 (en) | 2001-11-13 | 2012-08-07 | Edwards Lifesciences Corporation | Mitral annuloplasty ring having upward bows |
| US20080097593A1 (en)* | 2001-11-13 | 2008-04-24 | Bolling Steven F | Mitral Annuloplasty Ring Having Upward Bows |
| US7503929B2 (en) | 2002-01-02 | 2009-03-17 | Medtronic, Inc. | Prosthetic heart valve system |
| US7189258B2 (en) | 2002-01-02 | 2007-03-13 | Medtronic, Inc. | Heart valve system |
| US20060195181A1 (en)* | 2002-01-02 | 2006-08-31 | Johnson Keith M | Heart valve system |
| US20030125805A1 (en)* | 2002-01-02 | 2003-07-03 | Medtronic, Inc. | Heart valve system |
| US8029564B2 (en) | 2002-01-02 | 2011-10-04 | Medtronic, Inc. | Prosthetic heart valve system |
| US7033390B2 (en) | 2002-01-02 | 2006-04-25 | Medtronic, Inc. | Prosthetic heart valve system |
| US20040024451A1 (en)* | 2002-01-02 | 2004-02-05 | Medtronic, Inc. | Prosthetic heart valve system |
| US20060235510A1 (en)* | 2002-01-02 | 2006-10-19 | Johnson Keith M | Prosthetic heart valve system |
| US7468073B2 (en) | 2002-01-02 | 2008-12-23 | Medtronic, Inc. | Heart valve system |
| US20090198323A1 (en)* | 2002-01-02 | 2009-08-06 | Johnson Keith M | Prosthetic Heart Valve System |
| US7077862B2 (en) | 2002-01-09 | 2006-07-18 | Myocor, Inc. | Devices and methods for heart valve treatment |
| US7678145B2 (en) | 2002-01-09 | 2010-03-16 | Edwards Lifesciences Llc | Devices and methods for heart valve treatment |
| US8506624B2 (en) | 2002-01-09 | 2013-08-13 | Edwards Lifesciences, Llc | Devices and methods for heart valve treatment |
| US20070050022A1 (en)* | 2002-01-09 | 2007-03-01 | Myocor, Inc. | Devices and methods for heart valve treatment |
| US8070805B2 (en) | 2002-01-09 | 2011-12-06 | Edwards Lifesciences Llc | Devices and methods for heart valve treatment |
| US20080195200A1 (en)* | 2002-01-09 | 2008-08-14 | Myocor, Inc. | Devices and methods for heart valve treatment |
| US7066954B2 (en) | 2002-03-18 | 2006-06-27 | Medtronic, Inc. | Annuloplasty system |
| US7118595B2 (en) | 2002-03-18 | 2006-10-10 | Medtronic, Inc. | Flexible annuloplasty prosthesis and holder |
| US7637944B2 (en) | 2002-03-18 | 2009-12-29 | Medtronic, Inc. | Annuloplasty system |
| US7476247B2 (en) | 2002-03-18 | 2009-01-13 | Medtronic, Inc. | Flexible annuloplasty prosthesis and holder |
| US20030176917A1 (en)* | 2002-03-18 | 2003-09-18 | Medtronic, Inc. | Flexible annuloplasty prosthesis and holder |
| US20040186564A1 (en)* | 2002-03-18 | 2004-09-23 | Ryan Timothy R. | Annuloplasty system |
| US20070255397A1 (en)* | 2002-03-18 | 2007-11-01 | Ryan Timothy R | Flexible annuloplasty prosthesis and holder |
| US20060190077A1 (en)* | 2002-03-18 | 2006-08-24 | Ryan Timothy R | Annuloplasty system |
| US7220277B2 (en) | 2002-03-27 | 2007-05-22 | Sorin Biomedica Cardio S.P.A. | Prosthesis for annuloplasty comprising a perforated element |
| US20030220686A1 (en)* | 2002-03-27 | 2003-11-27 | Pietro Arru | Prosthesis for annuloplasty comprising a perforated element |
| EP2153799A1 (en) | 2002-03-27 | 2010-02-17 | Sorin Biomedica Cardio S.r.l. | A prosthesis for annuloplasty comprising a perforated element |
| EP2075014A2 (en) | 2002-05-24 | 2009-07-01 | Angiotech International Ag | Compositions and methods for coating medical implants |
| US20050107812A1 (en)* | 2002-06-13 | 2005-05-19 | Guided Delivery Systems, Inc. | Delivery devices and methods for heart valve repair |
| US10092402B2 (en) | 2002-06-13 | 2018-10-09 | Ancora Heart, Inc. | Devices and methods for heart valve repair |
| US10624741B2 (en) | 2002-06-13 | 2020-04-21 | Ancora Heart, Inc. | Delivery devices and methods for heart valve repair |
| US20050107810A1 (en)* | 2002-06-13 | 2005-05-19 | Guided Delivery Systems, Inc. | Devices and methods for heart valve repair |
| US20100082098A1 (en)* | 2002-06-13 | 2010-04-01 | Starksen Niel F | Delivery devices and methods for heart valve repair |
| US20080234701A1 (en)* | 2002-06-13 | 2008-09-25 | Guided Delivery Systems, Inc. | Devices and methods for heart valve repair |
| US8287557B2 (en) | 2002-06-13 | 2012-10-16 | Guided Delivery Systems, Inc. | Methods and devices for termination |
| US8641727B2 (en) | 2002-06-13 | 2014-02-04 | Guided Delivery Systems, Inc. | Devices and methods for heart valve repair |
| US8066766B2 (en) | 2002-06-13 | 2011-11-29 | Guided Delivery Systems Inc. | Methods and devices for termination |
| US9072513B2 (en) | 2002-06-13 | 2015-07-07 | Guided Delivery Systems Inc. | Methods and devices for termination |
| US7883538B2 (en) | 2002-06-13 | 2011-02-08 | Guided Delivery Systems Inc. | Methods and devices for termination |
| US9636107B2 (en) | 2002-06-13 | 2017-05-02 | Ancora Heart, Inc. | Devices and methods for heart valve repair |
| US20080234728A1 (en)* | 2002-06-13 | 2008-09-25 | Guided Delivery Systems, Inc. | Devices and methods for heart valve repair |
| US9949829B2 (en) | 2002-06-13 | 2018-04-24 | Ancora Heart, Inc. | Delivery devices and methods for heart valve repair |
| US20060025787A1 (en)* | 2002-06-13 | 2006-02-02 | Guided Delivery Systems, Inc. | Devices and methods for heart valve repair |
| US9468528B2 (en) | 2002-06-13 | 2016-10-18 | Guided Delivery Systems, Inc. | Devices and methods for heart valve repair |
| US20060190030A1 (en)* | 2002-06-13 | 2006-08-24 | John To | Methods and devices for termination |
| US20050107811A1 (en)* | 2002-06-13 | 2005-05-19 | Guided Delivery Systems, Inc. | Delivery devices and methods for heart valve repair |
| US20060241656A1 (en)* | 2002-06-13 | 2006-10-26 | Starksen Niel F | Delivery devices and methods for heart valve repair |
| US20060122633A1 (en)* | 2002-06-13 | 2006-06-08 | John To | Methods and devices for termination |
| US10898328B2 (en) | 2002-06-13 | 2021-01-26 | Ancora Heart, Inc. | Devices and methods for heart valve repair |
| US20080051837A1 (en)* | 2002-06-13 | 2008-02-28 | John To | Methods and devices for termination |
| US9226825B2 (en) | 2002-06-13 | 2016-01-05 | Guided Delivery Systems, Inc. | Delivery devices and methods for heart valve repair |
| US20040243227A1 (en)* | 2002-06-13 | 2004-12-02 | Guided Delivery Systems, Inc. | Delivery devices and methods for heart valve repair |
| US20100010625A1 (en)* | 2002-07-08 | 2010-01-14 | Edwards Lifesciences Corporation | Mitral valve annuloplasty ring having an offset posterior bow |
| US7993396B2 (en) | 2002-07-08 | 2011-08-09 | Edwards Lifesciences Corporation | Mitral valve annuloplasty ring having an offset posterior bow |
| US20040054303A1 (en)* | 2002-07-29 | 2004-03-18 | Taylor Geoffrey L. | Blanching response pressure sore detector apparatus and method |
| US8066724B2 (en) | 2002-09-12 | 2011-11-29 | Medtronic, Inc. | Anastomosis apparatus and methods |
| US7976556B2 (en) | 2002-09-12 | 2011-07-12 | Medtronic, Inc. | Anastomosis apparatus and methods |
| US8105345B2 (en) | 2002-10-04 | 2012-01-31 | Medtronic, Inc. | Anastomosis apparatus and methods |
| US8298251B2 (en) | 2002-10-04 | 2012-10-30 | Medtronic, Inc. | Anastomosis apparatus and methods |
| US7112219B2 (en) | 2002-11-12 | 2006-09-26 | Myocor, Inc. | Devices and methods for heart valve treatment |
| US7247134B2 (en) | 2002-11-12 | 2007-07-24 | Myocor, Inc. | Devices and methods for heart valve treatment |
| US7666224B2 (en) | 2002-11-12 | 2010-02-23 | Edwards Lifesciences Llc | Devices and methods for heart valve treatment |
| DE10301023A1 (en)* | 2003-01-13 | 2004-07-22 | Medos Medizintechnik Ag | Implant, in particular ring for heart valve, designed in curved and asymmetric shape |
| US20050004669A1 (en)* | 2003-01-13 | 2005-01-06 | Sievers Hans Hinrich | Implant with an annular base |
| US7276079B2 (en) | 2003-01-13 | 2007-10-02 | Medos Medizintechnik Ag | Implant with an annular base |
| US8287555B2 (en) | 2003-02-06 | 2012-10-16 | Guided Delivery Systems, Inc. | Devices and methods for heart valve repair |
| US20040193191A1 (en)* | 2003-02-06 | 2004-09-30 | Guided Delivery Systems, Inc. | Devices and methods for heart valve repair |
| US7122043B2 (en) | 2003-05-19 | 2006-10-17 | Stout Medical Group, L.P. | Tissue distention device and related methods for therapeutic intervention |
| US8758395B2 (en) | 2003-05-19 | 2014-06-24 | Septrx, Inc. | Embolic filtering method and apparatus |
| US7648532B2 (en) | 2003-05-19 | 2010-01-19 | Septrx, Inc. | Tissue distention device and related methods for therapeutic intervention |
| US20090275976A1 (en)* | 2003-05-19 | 2009-11-05 | Stout Medical Group, L.P. | Embolic filtering method and apparatus |
| US20060178694A1 (en)* | 2003-05-19 | 2006-08-10 | Secant Medical, Llc | Tissue distention device and related methods for therapeutic intervention |
| US20060009799A1 (en)* | 2003-05-19 | 2006-01-12 | Kleshinski Stephen J | Embolic filtering method and apparatus |
| US8211124B2 (en) | 2003-07-25 | 2012-07-03 | Medtronic, Inc. | Sealing clip, delivery systems, and methods |
| US20050038509A1 (en)* | 2003-08-14 | 2005-02-17 | Ashe Kassem Ali | Valve prosthesis including a prosthetic leaflet |
| US8029519B2 (en) | 2003-08-22 | 2011-10-04 | Medtronic, Inc. | Eversion apparatus and methods |
| US8343173B2 (en) | 2003-09-04 | 2013-01-01 | Guided Delivery Systems Inc. | Delivery devices and methods for heart valve repair |
| US7922762B2 (en) | 2003-09-04 | 2011-04-12 | Guided Delivery Systems Inc. | Devices and methods for cardiac annulus stabilization and treatment |
| US20080234815A1 (en)* | 2003-09-04 | 2008-09-25 | Guided Delivery Systems, Inc. | Devices and methods for cardiac annulus stabilization and treatment |
| US20080234704A1 (en)* | 2003-09-04 | 2008-09-25 | Guided Delivery Systems, Inc. | Delivery devices and methods for heart valve repair |
| US8394114B2 (en) | 2003-09-26 | 2013-03-12 | Medtronic, Inc. | Surgical connection apparatus and methods |
| US7879047B2 (en) | 2003-12-10 | 2011-02-01 | Medtronic, Inc. | Surgical connection apparatus and methods |
| US20080051832A1 (en)* | 2003-12-19 | 2008-02-28 | John To | Devices and methods for anchoring tissue |
| US20080051810A1 (en)* | 2003-12-19 | 2008-02-28 | John To | Devices and methods for anchoring tissue |
| US20080058868A1 (en)* | 2003-12-19 | 2008-03-06 | John To | Devices and methods for anchoring tissue |
| US20050273138A1 (en)* | 2003-12-19 | 2005-12-08 | Guided Delivery Systems, Inc. | Devices and methods for anchoring tissue |
| US20070071685A1 (en)* | 2003-12-22 | 2007-03-29 | Bracco Research S.A. | Gas-filled microvesicle assembly for contrast imaging |
| US20050197696A1 (en)* | 2004-02-23 | 2005-09-08 | Gomez Duran Carlos M. | Papilloplasty band and sizing device |
| US8206439B2 (en) | 2004-02-23 | 2012-06-26 | International Heart Institute Of Montana Foundation | Internal prosthesis for reconstruction of cardiac geometry |
| US20050237780A1 (en)* | 2004-04-21 | 2005-10-27 | Seiko Epson Corporation | Organic electroluminescent device, method of manufacture thereof and electronic apparatus |
| US7951196B2 (en) | 2004-04-29 | 2011-05-31 | Edwards Lifesciences Corporation | Annuloplasty ring for mitral valve prolapse |
| US7294148B2 (en) | 2004-04-29 | 2007-11-13 | Edwards Lifesciences Corporation | Annuloplasty ring for mitral valve prolapse |
| US20050246014A1 (en)* | 2004-04-29 | 2005-11-03 | Mccarthy Patrick M | Annuloplasty ring for mitral valve prolapse |
| US20050267572A1 (en)* | 2004-05-14 | 2005-12-01 | St. Jude Medical, Inc. | Systems and methods for holding annuloplasty rings |
| US7452376B2 (en) | 2004-05-14 | 2008-11-18 | St. Jude Medical, Inc. | Flexible, non-planar annuloplasty rings |
| US20110238170A1 (en)* | 2004-05-14 | 2011-09-29 | St. Jude Medical, Inc. | Heart valve annuloplasty prosthesis sewing cuffs and methods of making same |
| US20050256567A1 (en)* | 2004-05-14 | 2005-11-17 | St. Jude Medical, Inc. | Heart valve annuloplasty prosthesis sewing cuffs and methods of making same |
| US20050256569A1 (en)* | 2004-05-14 | 2005-11-17 | St. Jude Medical, Inc. | Flexible, non-planar annuloplasty rings |
| US9289294B2 (en) | 2004-05-14 | 2016-03-22 | St. Jude Medical, Inc. | Heart valve annuloplasty prosthesis sewing cuffs and methods of making same |
| US7938856B2 (en) | 2004-05-14 | 2011-05-10 | St. Jude Medical, Inc. | Heart valve annuloplasty prosthesis sewing cuffs and methods of making same |
| US8052748B2 (en) | 2004-05-14 | 2011-11-08 | St. Jude Medical, Inc. | Systems and methods for holding annuloplasty rings |
| US20050278022A1 (en)* | 2004-06-14 | 2005-12-15 | St. Jude Medical, Inc. | Annuloplasty prostheses with improved anchoring structures, and related methods |
| EP1913900A1 (en) | 2004-06-29 | 2008-04-23 | SIEVERS, Hans-Hinrich, Dr. | Implant with a ring-shaped base plate |
| US20080009941A1 (en)* | 2004-07-13 | 2008-01-10 | Hans Hinrich Sievers | Implant with an annular base |
| US7758638B2 (en) | 2004-07-13 | 2010-07-20 | Ats Medical, Inc. | Implant with an annular base |
| US20060039756A1 (en)* | 2004-08-19 | 2006-02-23 | Bernd Lemke | Self-propelled device for milling road surfaces |
| US20060082069A1 (en)* | 2004-10-14 | 2006-04-20 | Malavazi Vedacoes Industriais Ltda | Bearing-supported mechanical seal for progressive cavity pumps |
| CN100421632C (en)* | 2005-02-01 | 2008-10-01 | 金磊 | artificial heart valvuloplasty ring |
| US11497605B2 (en) | 2005-03-17 | 2022-11-15 | Valtech Cardio Ltd. | Mitral valve treatment techniques |
| US10561498B2 (en) | 2005-03-17 | 2020-02-18 | Valtech Cardio, Ltd. | Mitral valve treatment techniques |
| US9526613B2 (en) | 2005-03-17 | 2016-12-27 | Valtech Cardio Ltd. | Mitral valve treatment techniques |
| US20110015727A1 (en)* | 2005-03-23 | 2011-01-20 | Edwards Lifesciences Corporation | Annuloplasty Ring and Holder Combination |
| US7842085B2 (en) | 2005-03-23 | 2010-11-30 | Vaso Adzich | Annuloplasty ring and holder combination |
| US7575595B2 (en) | 2005-03-23 | 2009-08-18 | Edwards Lifesciences Corporation | Annuloplasty ring and holder combination |
| US20070156234A1 (en)* | 2005-03-23 | 2007-07-05 | Vaso Adzich | Apparatus, system, and method for delivering an annuloplasty ring |
| US20060217803A1 (en)* | 2005-03-23 | 2006-09-28 | Ingle Aaron S | Apparatus, system, and method for delivering an annuloplasty ring |
| US8216304B2 (en) | 2005-03-23 | 2012-07-10 | Edwards Lifesciences Corporation | Annuloplasty ring and holder combination |
| US12035898B2 (en) | 2005-04-22 | 2024-07-16 | Edwards Lifesciences Corporation | Catheter-based tissue remodeling devices and methods |
| US9006487B2 (en) | 2005-06-15 | 2015-04-14 | Massachusetts Institute Of Technology | Amine-containing lipids and uses thereof |
| US20110009641A1 (en)* | 2005-06-15 | 2011-01-13 | Anderson Daniel G | Amine-containing lipids and uses thereof |
| US20070123979A1 (en)* | 2005-06-27 | 2007-05-31 | Patrick Perier | Apparatus, system, and method for treatment of posterior leaflet prolapse |
| US8685083B2 (en) | 2005-06-27 | 2014-04-01 | Edwards Lifesciences Corporation | Apparatus, system, and method for treatment of posterior leaflet prolapse |
| US10695046B2 (en) | 2005-07-05 | 2020-06-30 | Edwards Lifesciences Corporation | Tissue anchor and anchoring system |
| US20070055206A1 (en)* | 2005-08-10 | 2007-03-08 | Guided Delivery Systems, Inc. | Methods and devices for deployment of tissue anchors |
| US11241314B2 (en) | 2005-09-07 | 2022-02-08 | Medtentia International Ltd Oy | Device and method for improving the function of a heart valve |
| US10195029B2 (en) | 2005-09-07 | 2019-02-05 | Medtentia Internatinal Ltd Oy | Device and method for improving the function of a heart valve |
| US20070078468A1 (en)* | 2005-09-30 | 2007-04-05 | Ryan Timothy R | Tool and method for implanting an annuloplasty prosthesis |
| US8048152B2 (en) | 2005-09-30 | 2011-11-01 | Medtronic, Inc. | Method of implanting an annuloplasty prosthesis |
| US20070078514A1 (en)* | 2005-09-30 | 2007-04-05 | Ryan Timothy R | Method of implanting an annuloplasty prosthesis |
| WO2007040998A1 (en)* | 2005-09-30 | 2007-04-12 | Medtronic, Inc. | Flexible annuloplasty prosthesis |
| US20070191939A1 (en)* | 2005-09-30 | 2007-08-16 | Tim Ryan | Flexible annuloplasty prosthesis |
| US9011528B2 (en) | 2005-09-30 | 2015-04-21 | Medtronic, Inc. | Flexible annuloplasty prosthesis |
| US8007530B2 (en) | 2005-09-30 | 2011-08-30 | Medtronic, Inc. | Tool and method for implanting an annuloplasty prosthesis |
| US20100023117A1 (en)* | 2005-12-15 | 2010-01-28 | Georgia Tech Research Corporation | Papillary muscle position control devices, systems, & methods |
| US9125742B2 (en) | 2005-12-15 | 2015-09-08 | Georgia Tech Research Foundation | Papillary muscle position control devices, systems, and methods |
| US8568473B2 (en) | 2005-12-15 | 2013-10-29 | Georgia Tech Research Corporation | Systems and methods for enabling heart valve replacement |
| US10039531B2 (en) | 2005-12-15 | 2018-08-07 | Georgia Tech Research Corporation | Systems and methods to control the dimension of a heart valve |
| US20090157174A1 (en)* | 2005-12-15 | 2009-06-18 | Georgia Tech Reasearch Corporation | Systems and methods for enabling heart valve replacement |
| US10010419B2 (en) | 2005-12-15 | 2018-07-03 | Georgia Tech Research Corporation | Papillary muscle position control devices, systems, and methods |
| US20070162112A1 (en)* | 2005-12-28 | 2007-07-12 | Sorin Biomedica Cardio | Annuloplasty prosthesis with an auxetic structure |
| US8034103B2 (en) | 2005-12-28 | 2011-10-11 | Sorin Biomedica Cardio S.R.L. | Annuloplasty prosthesis with an auxetic structure |
| US8142495B2 (en) | 2006-05-15 | 2012-03-27 | Edwards Lifesciences Ag | System and a method for altering the geometry of the heart |
| US20100063586A1 (en)* | 2006-05-15 | 2010-03-11 | John Michael Hasenkam | System and a method for altering the geometry of the heart |
| US8591576B2 (en) | 2006-05-15 | 2013-11-26 | Edwards Lifesciences Ag | Method for altering the geometry of the heart |
| US9283073B2 (en) | 2006-06-02 | 2016-03-15 | Medtronic, Inc. | Annuloplasty ring and method |
| US20070299514A1 (en)* | 2006-06-02 | 2007-12-27 | Colvin Stephen B | Annuloplasty prosthesis with in vivo shape identification and related methods of use |
| US8197538B2 (en) | 2006-06-02 | 2012-06-12 | Medtronic, Inc. | Annuloplasty prosthesis with in vivo shape identification and related methods of use |
| US20070299513A1 (en)* | 2006-06-02 | 2007-12-27 | Ryan Timothy R | Annuloplasty ring and method |
| US20080058924A1 (en)* | 2006-09-01 | 2008-03-06 | Aaron Ingle | Saddle-shaped annuloplasty ring |
| US20080086203A1 (en)* | 2006-10-06 | 2008-04-10 | Roberts Harold G | Mitral and tricuspid annuloplasty rings |
| US8382828B2 (en) | 2006-10-06 | 2013-02-26 | Edwards Lifesciences Corporation | Mitral annuloplasty rings |
| US7879087B2 (en)* | 2006-10-06 | 2011-02-01 | Edwards Lifesciences Corporation | Mitral and tricuspid annuloplasty rings |
| US20080172035A1 (en)* | 2006-10-18 | 2008-07-17 | Starksen Niel F | Methods and devices for catheter advancement and delivery of substances therethrough |
| US8388680B2 (en) | 2006-10-18 | 2013-03-05 | Guided Delivery Systems, Inc. | Methods and devices for catheter advancement and delivery of substances therethrough |
| US20080161825A1 (en)* | 2006-11-20 | 2008-07-03 | Stout Medical Group, L.P. | Anatomical measurement tool |
| US11259924B2 (en) | 2006-12-05 | 2022-03-01 | Valtech Cardio Ltd. | Implantation of repair devices in the heart |
| US7988725B2 (en) | 2006-12-05 | 2011-08-02 | Valtech Cardio, Ltd. | Segmented ring placement |
| US9883943B2 (en) | 2006-12-05 | 2018-02-06 | Valtech Cardio, Ltd. | Implantation of repair devices in the heart |
| US11344414B2 (en) | 2006-12-05 | 2022-05-31 | Valtech Cardio Ltd. | Implantation of repair devices in the heart |
| US20080262609A1 (en)* | 2006-12-05 | 2008-10-23 | Valtech Cardio, Ltd. | Segmented ring placement |
| US9872769B2 (en) | 2006-12-05 | 2018-01-23 | Valtech Cardio, Ltd. | Implantation of repair devices in the heart |
| US10357366B2 (en) | 2006-12-05 | 2019-07-23 | Valtech Cardio, Ltd. | Implantation of repair devices in the heart |
| US9974653B2 (en) | 2006-12-05 | 2018-05-22 | Valtech Cardio, Ltd. | Implantation of repair devices in the heart |
| US8926695B2 (en) | 2006-12-05 | 2015-01-06 | Valtech Cardio, Ltd. | Segmented ring placement |
| US20090259307A1 (en)* | 2006-12-05 | 2009-10-15 | Valtech Cardio, Ltd. | Segmented ring placement |
| US9351830B2 (en) | 2006-12-05 | 2016-05-31 | Valtech Cardio, Ltd. | Implant and anchor placement |
| US10363137B2 (en) | 2006-12-05 | 2019-07-30 | Valtech Cardio, Ltd. | Implantation of repair devices in the heart |
| RU2324457C1 (en)* | 2007-01-09 | 2008-05-20 | Закрытое Акционерное Общество Научно-Производственное Предприятие "Мединж" | D-shaped ring for annuloplasty of tricuspid valve |
| US20080177380A1 (en)* | 2007-01-19 | 2008-07-24 | Starksen Niel F | Methods and devices for heart tissue repair |
| US20110238171A1 (en)* | 2007-02-09 | 2011-09-29 | Carpentier Alain F | Mitral annuloplasty rings with sewing cuff |
| US7959673B2 (en) | 2007-02-09 | 2011-06-14 | Edwards Lifesciences Corporation | Degenerative valvular disease specific annuloplasty rings |
| US20090157176A1 (en)* | 2007-02-09 | 2009-06-18 | Alain Carpentier | Annuloplasty rings for correcting degenerative valvular diseases |
| US20090177276A1 (en)* | 2007-02-09 | 2009-07-09 | Edwards Lifesciences Corporation | Degenerative Valvular Disease Specific Annuloplasty Rings |
| US20110034999A1 (en)* | 2007-02-09 | 2011-02-10 | Edwards Lifesciences Corporation | Degenerative valvular disease specific annuloplasty rings |
| US8764821B2 (en) | 2007-02-09 | 2014-07-01 | Edwards Lifesciences Corporation | Degenerative vavlular disease specific annuloplasty ring sets |
| US20110224786A1 (en)* | 2007-02-09 | 2011-09-15 | Edwards Lifesciences Corporation | Degenerative Valvular Disease Specific Annuloplasty Rings |
| US9011529B2 (en) | 2007-02-09 | 2015-04-21 | Edwards Lifesciences Corporation | Mitral annuloplasty rings with sewing cuff |
| US11660190B2 (en) | 2007-03-13 | 2023-05-30 | Edwards Lifesciences Corporation | Tissue anchors, systems and methods, and devices |
| US20080275551A1 (en)* | 2007-05-01 | 2008-11-06 | Edwards Lifesciences Corporation | Inwardly-bowed tricuspid annuloplasty ring |
| US8529620B2 (en) | 2007-05-01 | 2013-09-10 | Ottavio Alfieri | Inwardly-bowed tricuspid annuloplasty ring |
| US9101472B2 (en) | 2007-09-07 | 2015-08-11 | Edwards Lifesciences Corporation | Active holder for annuloplasty ring delivery |
| US11576784B2 (en) | 2007-09-07 | 2023-02-14 | Edwards Lifesciences Corporation | Active holder for annuloplasty ring delivery |
| US10842629B2 (en) | 2007-09-07 | 2020-11-24 | Edwards Lifesciences Corporation | Active holder for annuloplasty ring delivery |
| US8273118B2 (en) | 2007-09-17 | 2012-09-25 | Medtronic, Inc. | Heart valve holder assembly for use in valve implantation procedures |
| US20090076599A1 (en)* | 2007-09-17 | 2009-03-19 | Medtronics, Inc. | Heart valve holder assembly for use in valve implantation procedures |
| US20090234318A1 (en)* | 2007-10-19 | 2009-09-17 | Guided Delivery Systems, Inc. | Systems and methods for cardiac remodeling |
| US9125632B2 (en) | 2007-10-19 | 2015-09-08 | Guided Delivery Systems, Inc. | Systems and methods for cardiac remodeling |
| US20100049213A1 (en)* | 2007-10-19 | 2010-02-25 | Guided Delivery Systems Inc. | Devices and methods for termination |
| US7993395B2 (en) | 2008-01-25 | 2011-08-09 | Medtronic, Inc. | Set of annuloplasty devices with varying anterior-posterior ratios and related methods |
| US20090192606A1 (en)* | 2008-01-25 | 2009-07-30 | Medtronic, Inc. | Holder Devices for Annuloplasty Devices Having a Plurality of Anterior-Posterior Ratios |
| US8961598B2 (en) | 2008-01-25 | 2015-02-24 | Medtronic, Inc. | Set of annuloplasty devices with varying anterior-posterior ratios and related methods |
| US20090192605A1 (en)* | 2008-01-25 | 2009-07-30 | Medtronic, Inc. | Sizer Device Having a Plurality of Anterior-Posterior Ratios |
| US8795353B2 (en) | 2008-01-25 | 2014-08-05 | Medtronic, Inc. | Holder devices for annuloplasty devices having a plurality of anterior-posterior ratios |
| US9706996B2 (en) | 2008-02-06 | 2017-07-18 | Ancora Heart, Inc. | Multi-window guide tunnel |
| US10542987B2 (en) | 2008-02-06 | 2020-01-28 | Ancora Heart, Inc. | Multi-window guide tunnel |
| US20100094248A1 (en)* | 2008-02-06 | 2010-04-15 | Guided Delivery Systems Inc. | Multi-window guide tunnel |
| US8790367B2 (en) | 2008-02-06 | 2014-07-29 | Guided Delivery Systems Inc. | Multi-window guide tunnel |
| US12082813B2 (en) | 2008-02-06 | 2024-09-10 | Ancora Heart, Inc. | Multi-window guide tunnel |
| US20090222083A1 (en)* | 2008-02-06 | 2009-09-03 | Guided Delivery Systems Inc. | Multi-window guide tunnel |
| US8177836B2 (en) | 2008-03-10 | 2012-05-15 | Medtronic, Inc. | Apparatus and methods for minimally invasive valve repair |
| US11660191B2 (en) | 2008-03-10 | 2023-05-30 | Edwards Lifesciences Corporation | Method to reduce mitral regurgitation |
| US10363392B2 (en) | 2008-05-07 | 2019-07-30 | Ancora Heart, Inc. | Deflectable guide |
| US8096985B2 (en) | 2008-05-07 | 2012-01-17 | Guided Delivery Systems Inc. | Deflectable guide |
| US20090287187A1 (en)* | 2008-05-07 | 2009-11-19 | Guided Delivery Systems Inc. | Deflectable guide |
| US8568476B2 (en) | 2008-05-09 | 2013-10-29 | Edwards Lifesciences Corporation | Methods of assembling and delivering a cardiac implant |
| US8152844B2 (en) | 2008-05-09 | 2012-04-10 | Edwards Lifesciences Corporation | Quick-release annuloplasty ring holder |
| US9937041B2 (en) | 2008-05-13 | 2018-04-10 | Edwards Lifesciences Corporation | Physiologically harmonized tricuspid annuloplasty ring |
| US11903830B2 (en) | 2008-05-13 | 2024-02-20 | Edwards Lifesciences Corporation | Physiologically harmonized repair of tricuspid valve |
| US20090287303A1 (en)* | 2008-05-13 | 2009-11-19 | Edwards Lifesciences Corporation | Physiologically harmonized tricuspid annuloplasty ring |
| EP3628362A1 (en) | 2008-06-16 | 2020-04-01 | Valtech Cardio, Ltd. | Annuloplasty devices and methods of delivery therefor |
| US9192472B2 (en) | 2008-06-16 | 2015-11-24 | Valtec Cardio, Ltd. | Annuloplasty devices and methods of delivery therefor |
| US11039922B2 (en) | 2008-09-19 | 2021-06-22 | Edwards Lifesciences Corporation | Prosthetic heart valve for transcatheter heart valve implantation |
| US10052200B2 (en) | 2008-09-19 | 2018-08-21 | Edwards Lifesciences Corporation | Surgical heart valves adapted for post implant expansion |
| US9314335B2 (en) | 2008-09-19 | 2016-04-19 | Edwards Lifesciences Corporation | Prosthetic heart valve configured to receive a percutaneous prosthetic heart valve implantation |
| US11103348B2 (en) | 2008-09-19 | 2021-08-31 | Edwards Lifesciences Corporation | Method for converting an annuloplasty ring in vivo |
| US10478301B2 (en) | 2008-09-19 | 2019-11-19 | Edwards Lifesciences Corporation | Convertible annuloplasty ring configured to receive an expandable prosthetic heart valve |
| US8287591B2 (en) | 2008-09-19 | 2012-10-16 | Edwards Lifesciences Corporation | Transformable annuloplasty ring configured to receive a percutaneous prosthetic heart valve implantation |
| US20100076549A1 (en)* | 2008-09-19 | 2010-03-25 | Edwards Lifesciences Corporation | Annuloplasty Ring Configured to Receive a Percutaneous Prosthetic Heart Valve Implantation |
| US12396846B2 (en) | 2008-09-19 | 2025-08-26 | Edwards Lifesciences Corporation | Methods of implanting a prosthetic heart valve within another |
| US20100076548A1 (en)* | 2008-09-19 | 2010-03-25 | Edwards Lifesciences Corporation | Prosthetic Heart Valve Configured to Receive a Percutaneous Prosthetic Heart Valve Implantation |
| US10231836B2 (en) | 2008-09-19 | 2019-03-19 | Edwards Lifesciences Corporation | Surgical heart valve for transcatheter heart valve implantation |
| US9636219B2 (en) | 2008-09-19 | 2017-05-02 | Edwards Lifesciences Corporation | Cardiac implant configured to receive a percutaneous prosthetic heart valve implantation |
| US8795298B2 (en) | 2008-10-10 | 2014-08-05 | Guided Delivery Systems Inc. | Tether tensioning devices and related methods |
| US9636106B2 (en) | 2008-10-10 | 2017-05-02 | Ancora Heart, Inc. | Termination devices and related methods |
| US20100094314A1 (en)* | 2008-10-10 | 2010-04-15 | Hernlund Jonathan D | Tether tensioning devices and related methods |
| US20100121349A1 (en)* | 2008-10-10 | 2010-05-13 | Meier Stephen C | Termination devices and related methods |
| US8969353B2 (en) | 2008-11-07 | 2015-03-03 | Massachusetts Institute Of Technology | Aminoalcohol lipidoids and uses thereof |
| US10844028B2 (en) | 2008-11-07 | 2020-11-24 | Massachusetts Institute Of Technology | Aminoalcohol lipidoids and uses thereof |
| US9556110B2 (en) | 2008-11-07 | 2017-01-31 | Massachusetts Institute Of Technology | Aminoalcohol lipidoids and uses thereof |
| US10189802B2 (en) | 2008-11-07 | 2019-01-29 | Massachusetts Institute Of Technology | Aminoalcohol lipidoids and uses thereof |
| US11414393B2 (en) | 2008-11-07 | 2022-08-16 | Massachusetts Institute Of Technology | Aminoalcohol lipidoids and uses thereof |
| US20100152844A1 (en)* | 2008-12-15 | 2010-06-17 | Couetil Jean-Paul A | Annuloplasty ring with directional flexibilities and rigidities to assist the mitral annulus dynamics |
| WO2010070455A1 (en) | 2008-12-15 | 2010-06-24 | Jean-Paul Couetil | Annuloplasty ring with directional flexibilities and rigidities to assist the mitral annulus dynamics |
| WO2010070649A1 (en) | 2008-12-21 | 2010-06-24 | Mor Research Applications Ltd. | Elongated body for deployment in a coronary sinus |
| US10470882B2 (en) | 2008-12-22 | 2019-11-12 | Valtech Cardio, Ltd. | Closure element for use with annuloplasty structure |
| US9662209B2 (en) | 2008-12-22 | 2017-05-30 | Valtech Cardio, Ltd. | Contractible annuloplasty structures |
| US11116634B2 (en) | 2008-12-22 | 2021-09-14 | Valtech Cardio Ltd. | Annuloplasty implants |
| US10517719B2 (en) | 2008-12-22 | 2019-12-31 | Valtech Cardio, Ltd. | Implantation of repair devices in the heart |
| US9713530B2 (en) | 2008-12-22 | 2017-07-25 | Valtech Cardio, Ltd. | Adjustable annuloplasty devices and adjustment mechanisms therefor |
| US10856986B2 (en) | 2008-12-22 | 2020-12-08 | Valtech Cardio, Ltd. | Adjustable annuloplasty devices and adjustment mechanisms therefor |
| US12138168B2 (en) | 2008-12-22 | 2024-11-12 | Edwards Lifesciences Innovation (Israel) Ltd. | Adjustable annuloplasty devices and adjustment mechanisms therefor |
| US9011530B2 (en) | 2008-12-22 | 2015-04-21 | Valtech Cardio, Ltd. | Partially-adjustable annuloplasty structure |
| US20100198208A1 (en)* | 2009-01-20 | 2010-08-05 | Napp Malte I | Diagnostic catheters, guide catheters, visualization devices and chord manipulation devices, and related kits and methods |
| US10625047B2 (en) | 2009-01-20 | 2020-04-21 | Ancora Heart, Inc. | Anchor deployment devices and related methods |
| US10625046B2 (en) | 2009-01-20 | 2020-04-21 | Ancora Heart, Inc. | Diagnostic catheters, guide catheters, visualization devices and chord manipulation devices, and related kits and methods |
| US20100185172A1 (en)* | 2009-01-20 | 2010-07-22 | Mariel Fabro | Diagnostic catheters, guide catheters, visualization devices and chord manipulation devices, and related kits and methods |
| US11980722B2 (en) | 2009-01-20 | 2024-05-14 | Ancora Heart, Inc. | Diagnostic catheters, guide catheters, visualization devices and chord manipulation devices, and related kits and methods |
| US20100198056A1 (en)* | 2009-01-20 | 2010-08-05 | Mariel Fabro | Diagnostic catheters, guide catheters, visualization devices and chord manipulation devices, and related kits and methods |
| US9173646B2 (en) | 2009-01-20 | 2015-11-03 | Guided Delivery Systems Inc. | Diagnostic catheters, guide catheters, visualization devices and chord manipulation devices, and related kits and methods |
| US11202883B2 (en) | 2009-01-20 | 2021-12-21 | Ancora Heart, Inc. | Diagnostic catheters, guide catheters, visualization devices and chord manipulation devices, and related kits and methods |
| US20100198192A1 (en)* | 2009-01-20 | 2010-08-05 | Eugene Serina | Anchor deployment devices and related methods |
| US9616197B2 (en) | 2009-01-20 | 2017-04-11 | Ancora Heart, Inc. | Anchor deployment devices and related methods |
| US20100211166A1 (en)* | 2009-02-17 | 2010-08-19 | Eran Miller | Actively-engageable movement-restriction mechanism for use with an annuloplasty structure |
| US10350068B2 (en) | 2009-02-17 | 2019-07-16 | Valtech Cardio, Ltd. | Actively-engageable movement-restriction mechanism for use with an annuloplasty structure |
| US11202709B2 (en) | 2009-02-17 | 2021-12-21 | Valtech Cardio Ltd. | Actively-engageable movement-restriction mechanism for use with an annuloplasty structure |
| US8353956B2 (en) | 2009-02-17 | 2013-01-15 | Valtech Cardio, Ltd. | Actively-engageable movement-restriction mechanism for use with an annuloplasty structure |
| US9561104B2 (en) | 2009-02-17 | 2017-02-07 | Valtech Cardio, Ltd. | Actively-engageable movement-restriction mechanism for use with an annuloplasty structure |
| US20100262167A1 (en)* | 2009-04-09 | 2010-10-14 | Medtronic, Inc. | Medical Clip with Radial Tines, System and Method of Using Same |
| US8518060B2 (en) | 2009-04-09 | 2013-08-27 | Medtronic, Inc. | Medical clip with radial tines, system and method of using same |
| US8668704B2 (en) | 2009-04-24 | 2014-03-11 | Medtronic, Inc. | Medical clip with tines, system and method of using same |
| US20100274267A1 (en)* | 2009-04-24 | 2010-10-28 | Medtronics, Inc. | Medical Clip with Tines, System and Method of Using Same |
| US11076958B2 (en) | 2009-05-04 | 2021-08-03 | Valtech Cardio, Ltd. | Annuloplasty ring delivery catheters |
| US12350158B2 (en) | 2009-05-04 | 2025-07-08 | Edwards Lifesciences Innovation (Israel) Ltd. | Annuloplasty ring delivery catheters |
| US12350149B2 (en) | 2009-05-04 | 2025-07-08 | Edwards Lifesciences Innovation (Israel) Ltd. | Method and apparatus for repairing a heart valve |
| US9968452B2 (en) | 2009-05-04 | 2018-05-15 | Valtech Cardio, Ltd. | Annuloplasty ring delivery cathethers |
| US11844665B2 (en) | 2009-05-04 | 2023-12-19 | Edwards Lifesciences Innovation (Israel) Ltd. | Deployment techniques for annuloplasty structure |
| US10548729B2 (en) | 2009-05-04 | 2020-02-04 | Valtech Cardio, Ltd. | Deployment techniques for annuloplasty ring and over-wire rotation tool |
| US11185412B2 (en) | 2009-05-04 | 2021-11-30 | Valtech Cardio Ltd. | Deployment techniques for annuloplasty implants |
| US11766327B2 (en) | 2009-05-04 | 2023-09-26 | Edwards Lifesciences Innovation (Israel) Ltd. | Implantation of repair chords in the heart |
| US9474606B2 (en) | 2009-05-04 | 2016-10-25 | Valtech Cardio, Ltd. | Over-wire implant contraction methods |
| US9937042B2 (en) | 2009-05-07 | 2018-04-10 | Valtech Cardio, Ltd. | Multiple anchor delivery tool |
| US10856987B2 (en) | 2009-05-07 | 2020-12-08 | Valtech Cardio, Ltd. | Multiple anchor delivery tool |
| US9119719B2 (en) | 2009-05-07 | 2015-09-01 | Valtech Cardio, Ltd. | Annuloplasty ring with intra-ring anchoring |
| US11723774B2 (en) | 2009-05-07 | 2023-08-15 | Edwards Lifesciences Innovation (Israel) Ltd. | Multiple anchor delivery tool |
| US9592122B2 (en) | 2009-05-07 | 2017-03-14 | Valtech Cardio, Ltd | Annuloplasty ring with intra-ring anchoring |
| WO2011033508A1 (en) | 2009-09-15 | 2011-03-24 | Transcardia Ltd. | Heart valve remodeling |
| US11617652B2 (en) | 2009-10-29 | 2023-04-04 | Edwards Lifesciences Innovation (Israel) Ltd. | Apparatus and method for guide-wire based advancement of an adjustable implant |
| US11141271B2 (en) | 2009-10-29 | 2021-10-12 | Valtech Cardio Ltd. | Tissue anchor for annuloplasty device |
| US12097118B2 (en) | 2009-10-29 | 2024-09-24 | Edwards Lifesciences Innovation (Israel) Ltd. | Tissue anchor for heart implant |
| US10098737B2 (en) | 2009-10-29 | 2018-10-16 | Valtech Cardio, Ltd. | Tissue anchor for annuloplasty device |
| US9414921B2 (en) | 2009-10-29 | 2016-08-16 | Valtech Cardio, Ltd. | Tissue anchor for annuloplasty device |
| US10751184B2 (en) | 2009-10-29 | 2020-08-25 | Valtech Cardio, Ltd. | Apparatus and method for guide-wire based advancement of an adjustable implant |
| US9968454B2 (en) | 2009-10-29 | 2018-05-15 | Valtech Cardio, Ltd. | Techniques for guide-wire based advancement of artificial chordae |
| US10576166B2 (en) | 2009-12-01 | 2020-03-03 | Translate Bio, Inc. | Liver specific delivery of messenger RNA |
| US9622861B2 (en) | 2009-12-02 | 2017-04-18 | Valtech Cardio, Ltd. | Tool for actuating an adjusting mechanism |
| US11602434B2 (en) | 2009-12-02 | 2023-03-14 | Edwards Lifesciences Innovation (Israel) Ltd. | Systems and methods for tissue adjustment |
| US10492909B2 (en) | 2009-12-02 | 2019-12-03 | Valtech Cardio, Ltd. | Tool for actuating an adjusting mechanism |
| US10548726B2 (en) | 2009-12-08 | 2020-02-04 | Cardiovalve Ltd. | Rotation-based anchoring of an implant |
| US10231831B2 (en) | 2009-12-08 | 2019-03-19 | Cardiovalve Ltd. | Folding ring implant for heart valve |
| US11351026B2 (en) | 2009-12-08 | 2022-06-07 | Cardiovalve Ltd. | Rotation-based anchoring of an implant |
| US11141268B2 (en) | 2009-12-08 | 2021-10-12 | Cardiovalve Ltd. | Prosthetic heart valve with upper and lower skirts |
| US11839541B2 (en) | 2009-12-08 | 2023-12-12 | Cardiovalve Ltd. | Prosthetic heart valve with upper skirt |
| US20110160849A1 (en)* | 2009-12-22 | 2011-06-30 | Edwards Lifesciences Corporation | Bimodal tricuspid annuloplasty ring |
| US8449608B2 (en) | 2010-01-22 | 2013-05-28 | Edwards Lifesciences Corporation | Tricuspid ring |
| US20110184511A1 (en)* | 2010-01-22 | 2011-07-28 | Edwards Lifesciences Corporation | Tricuspid ring |
| US8992606B2 (en) | 2010-03-19 | 2015-03-31 | Xavier Ruyra Baliarda | Prosthetic device for repairing a mitral valve |
| US11653910B2 (en) | 2010-07-21 | 2023-05-23 | Cardiovalve Ltd. | Helical anchor implantation |
| US12310575B2 (en) | 2010-07-21 | 2025-05-27 | Cardiovalve Ltd. | Helical anchor implantation |
| US10524911B2 (en) | 2010-08-24 | 2020-01-07 | Edwards Lifesciences Corporation | Flexible annuloplasty ring with select control points |
| US10940003B2 (en) | 2010-08-24 | 2021-03-09 | Edwards Lifesciences Corporation | Methods of delivering a flexible annuloplasty ring |
| US9326858B2 (en) | 2010-08-24 | 2016-05-03 | Edwards Lifesciences Corporation | Flexible annuloplasty ring |
| US10182912B2 (en) | 2010-08-24 | 2019-01-22 | Edwards Lifesciences Corporation | Methods of delivering a flexible annuloplasty ring |
| US9193827B2 (en) | 2010-08-26 | 2015-11-24 | Massachusetts Institute Of Technology | Poly(beta-amino alcohols), their preparation, and uses thereof |
| US8915960B2 (en) | 2010-08-31 | 2014-12-23 | Edwards Lifesciences Corporation | Physiologic tricuspid annuloplasty ring |
| US9861350B2 (en) | 2010-09-03 | 2018-01-09 | Ancora Heart, Inc. | Devices and methods for anchoring tissue |
| US10543089B2 (en) | 2010-11-30 | 2020-01-28 | Edwards Lifesciences Corporation | Annuloplasty ring with reduced dehiscence |
| US11872132B2 (en) | 2010-11-30 | 2024-01-16 | Edwards Lifesciences Corporation | Methods of implanting an annuloplasty ring for reduced dehiscence |
| US9474607B2 (en) | 2010-11-30 | 2016-10-25 | Edwards Lifesciences Corporation | Methods of implanting an annuloplasty ring for reduced dehiscence |
| US8932350B2 (en) | 2010-11-30 | 2015-01-13 | Edwards Lifesciences Corporation | Reduced dehiscence annuloplasty ring |
| US8845717B2 (en) | 2011-01-28 | 2014-09-30 | Middle Park Medical, Inc. | Coaptation enhancement implant, system, and method |
| US11678986B2 (en) | 2011-01-28 | 2023-06-20 | Polares Medical Inc. | Device, system, and method for transcatheter treatment of valve regurgitation |
| US10470883B2 (en) | 2011-01-28 | 2019-11-12 | Polares Medical Inc. | Coaptation enhancement implant, system, and method |
| US12150856B2 (en) | 2011-01-28 | 2024-11-26 | Polares Medical Inc. | Device, system, and method for transcatheter treatment of valve regurgitation |
| US9610163B2 (en) | 2011-01-28 | 2017-04-04 | Middle Peak Medical, Inc. | Coaptation enhancement implant, system, and method |
| US11413145B2 (en) | 2011-01-28 | 2022-08-16 | Polares Medical Inc. | Coaptation enhancement implant, system, and method |
| US9592118B2 (en) | 2011-01-28 | 2017-03-14 | Middle Peak Medical, Inc. | Device, system, and method for transcatheter treatment of valve regurgitation |
| US11648120B2 (en) | 2011-01-28 | 2023-05-16 | Polares Medical Inc. | Coaptation enhancement implant, system, and method |
| US8888843B2 (en) | 2011-01-28 | 2014-11-18 | Middle Peak Medical, Inc. | Device, system, and method for transcatheter treatment of valve regurgitation |
| US11648119B2 (en) | 2011-01-28 | 2023-05-16 | Polares Medical Inc. | Coaptation enhancement implant, system, and method |
| US12109116B2 (en) | 2011-01-28 | 2024-10-08 | Polares Medical Inc. | Coaptation enhancement implant, system, and method |
| US10512542B2 (en) | 2011-01-28 | 2019-12-24 | Polares Medical Inc. | Device, system, and method for transcatheter treatment of valve regurgitation |
| US11426279B2 (en) | 2011-01-28 | 2022-08-30 | Polares Medical Inc. | Coaptation enhancement implant, system, and method |
| US11419722B2 (en) | 2011-01-28 | 2022-08-23 | Polares Medical Inc. | Device, system, and method for transcatheter treatment of valve regurgitation |
| US10709449B2 (en) | 2011-02-18 | 2020-07-14 | Ancora Heart, Inc. | Systems and methods for variable stiffness tethers |
| US10111663B2 (en) | 2011-02-18 | 2018-10-30 | Ancora Heart, Inc. | Implant retrieval device |
| US10117934B2 (en) | 2011-03-28 | 2018-11-06 | Massachusetts Institute Of Technology | Conjugated lipomers and uses thereof |
| US10933139B2 (en) | 2011-03-28 | 2021-03-02 | Massachusetts Institute Of Technology | Conjugated lipomers and uses thereof |
| US12390528B2 (en) | 2011-03-28 | 2025-08-19 | Massachusetts Institute Of Technology | Conjugated lipomers and uses thereof |
| US9238716B2 (en) | 2011-03-28 | 2016-01-19 | Massachusetts Institute Of Technology | Conjugated lipomers and uses thereof |
| US11951181B2 (en) | 2011-06-08 | 2024-04-09 | Translate Bio, Inc. | Lipid nanoparticle compositions and methods for mRNA delivery |
| US11547764B2 (en) | 2011-06-08 | 2023-01-10 | Translate Bio, Inc. | Lipid nanoparticle compositions and methods for MRNA delivery |
| US10238754B2 (en) | 2011-06-08 | 2019-03-26 | Translate Bio, Inc. | Lipid nanoparticle compositions and methods for MRNA delivery |
| US12121592B2 (en) | 2011-06-08 | 2024-10-22 | Translate Bio, Inc. | Lipid nanoparticle compositions and methods for mRNA delivery |
| US11185595B2 (en) | 2011-06-08 | 2021-11-30 | Translate Bio, Inc. | Lipid nanoparticle compositions and methods for mRNA delivery |
| US11291734B2 (en) | 2011-06-08 | 2022-04-05 | Translate Bio, Inc. | Lipid nanoparticle compositions and methods for mRNA delivery |
| US10507249B2 (en) | 2011-06-08 | 2019-12-17 | Translate Bio, Inc. | Lipid nanoparticle compositions and methods for mRNA delivery |
| US10350303B1 (en) | 2011-06-08 | 2019-07-16 | Translate Bio, Inc. | Lipid nanoparticle compositions and methods for mRNA delivery |
| US11052159B2 (en) | 2011-06-08 | 2021-07-06 | Translate Bio, Inc. | Lipid nanoparticle compositions and methods for mRNA delivery |
| US10888626B2 (en) | 2011-06-08 | 2021-01-12 | Translate Bio, Inc. | Lipid nanoparticle compositions and methods for mRNA delivery |
| US9308281B2 (en) | 2011-06-08 | 2016-04-12 | Shire Human Genetic Therapies, Inc. | MRNA therapy for Fabry disease |
| US11338044B2 (en) | 2011-06-08 | 2022-05-24 | Translate Bio, Inc. | Lipid nanoparticle compositions and methods for mRNA delivery |
| US10413618B2 (en) | 2011-06-08 | 2019-09-17 | Translate Bio, Inc. | Lipid nanoparticle compositions and methods for mRNA delivery |
| US11951179B2 (en) | 2011-06-08 | 2024-04-09 | Translate Bio, Inc. | Lipid nanoparticle compositions and methods for MRNA delivery |
| US11951180B2 (en) | 2011-06-08 | 2024-04-09 | Translate Bio, Inc. | Lipid nanoparticle compositions and methods for MRNA delivery |
| US11730825B2 (en) | 2011-06-08 | 2023-08-22 | Translate Bio, Inc. | Lipid nanoparticle compositions and methods for mRNA delivery |
| US9597413B2 (en) | 2011-06-08 | 2017-03-21 | Shire Human Genetic Therapies, Inc. | Pulmonary delivery of mRNA |
| US8940044B2 (en) | 2011-06-23 | 2015-01-27 | Valtech Cardio, Ltd. | Closure element for use with an annuloplasty structure |
| US12409032B2 (en) | 2011-06-23 | 2025-09-09 | Edwards Lifesciences Innovation (Israel) Ltd. | Percutaneous implantation of an annuloplasty structure |
| US10792152B2 (en) | 2011-06-23 | 2020-10-06 | Valtech Cardio, Ltd. | Closed band for percutaneous annuloplasty |
| US12138165B2 (en) | 2011-06-23 | 2024-11-12 | Edwards Lifesciences Innovation (Israel) Ltd. | Annuloplasty implants |
| US8920493B2 (en) | 2011-09-16 | 2014-12-30 | St. Jude Medical, Cardiology Division, Inc. | Systems and methods for holding annuloplasty rings |
| US11197759B2 (en) | 2011-11-04 | 2021-12-14 | Valtech Cardio Ltd. | Implant having multiple adjusting mechanisms |
| US9265608B2 (en) | 2011-11-04 | 2016-02-23 | Valtech Cardio, Ltd. | Implant having multiple rotational assemblies |
| US9775709B2 (en) | 2011-11-04 | 2017-10-03 | Valtech Cardio, Ltd. | Implant having multiple adjustable mechanisms |
| US12274620B2 (en) | 2011-11-04 | 2025-04-15 | Edwards Lifesciences Innovation (Israel) Ltd. | Implant having multiple adjusting mechanisms |
| US10363136B2 (en) | 2011-11-04 | 2019-07-30 | Valtech Cardio, Ltd. | Implant having multiple adjustment mechanisms |
| US9724192B2 (en) | 2011-11-08 | 2017-08-08 | Valtech Cardio, Ltd. | Controlled steering functionality for implant-delivery tool |
| US11857415B2 (en) | 2011-11-08 | 2024-01-02 | Edwards Lifesciences Innovation (Israel) Ltd. | Controlled steering functionality for implant-delivery tool |
| US10568738B2 (en) | 2011-11-08 | 2020-02-25 | Valtech Cardio, Ltd. | Controlled steering functionality for implant-delivery tool |
| US11969348B2 (en) | 2011-12-12 | 2024-04-30 | Edwards Lifesciences Corporation | Cardiac valve replacement |
| US11254936B2 (en) | 2012-06-08 | 2022-02-22 | Translate Bio, Inc. | Nuclease resistant polynucleotides and uses thereof |
| US11395648B2 (en) | 2012-09-29 | 2022-07-26 | Edwards Lifesciences Corporation | Plication lock delivery system and method of use thereof |
| US12414772B2 (en) | 2012-10-23 | 2025-09-16 | Edwards Lifesciences Innovation (Israel) Ltd. | Percutaneous tissue anchor techniques |
| US11890190B2 (en) | 2012-10-23 | 2024-02-06 | Edwards Lifesciences Innovation (Israel) Ltd. | Location indication system for implant-delivery tool |
| US10893939B2 (en) | 2012-10-23 | 2021-01-19 | Valtech Cardio, Ltd. | Controlled steering functionality for implant delivery tool |
| US12274618B2 (en) | 2012-10-23 | 2025-04-15 | Edwards Lifesciences Innovation (Israel) Ltd. | Location indication system for implant-delivery tool |
| US11344310B2 (en) | 2012-10-23 | 2022-05-31 | Valtech Cardio Ltd. | Percutaneous tissue anchor techniques |
| US10376266B2 (en) | 2012-10-23 | 2019-08-13 | Valtech Cardio, Ltd. | Percutaneous tissue anchor techniques |
| US9949828B2 (en) | 2012-10-23 | 2018-04-24 | Valtech Cardio, Ltd. | Controlled steering functionality for implant-delivery tool |
| US11583400B2 (en) | 2012-12-06 | 2023-02-21 | Edwards Lifesciences Innovation (Israel) Ltd. | Techniques for guided advancement of a tool |
| US12251307B2 (en) | 2012-12-06 | 2025-03-18 | Edwards Lifesciences Innovation (Israel) Ltd. | Techniques for guide-wire based advancement of a tool |
| US10610360B2 (en) | 2012-12-06 | 2020-04-07 | Valtech Cardio, Ltd. | Techniques for guide-wire based advancement of a tool |
| US9730793B2 (en) | 2012-12-06 | 2017-08-15 | Valtech Cardio, Ltd. | Techniques for guide-wire based advancement of a tool |
| US9375310B2 (en) | 2012-12-31 | 2016-06-28 | Edwards Lifesciences Corporation | Surgical heart valves adapted for post-implant expansion |
| US12226311B2 (en) | 2012-12-31 | 2025-02-18 | Edwards Lifesciences Corporation | Heart valve stents adapted for post-implant expansion |
| US10485661B2 (en) | 2012-12-31 | 2019-11-26 | Edwards Lifesciences Corporation | Surgical heart valves adapted for post-implant expansion |
| US11883282B2 (en) | 2012-12-31 | 2024-01-30 | Edwards Lifesciences Corporation | Assembly of heart valves and intermediate adapter stent |
| US11576772B2 (en) | 2012-12-31 | 2023-02-14 | Edwards Lifesciences Corporation | One-piece heart valve stents adapted for post-implant expansion |
| US10543085B2 (en) | 2012-12-31 | 2020-01-28 | Edwards Lifesciences Corporation | One-piece heart valve stents adapted for post-implant expansion |
| US9364322B2 (en) | 2012-12-31 | 2016-06-14 | Edwards Lifesciences Corporation | Post-implant expandable surgical heart valve configurations |
| US11844691B2 (en) | 2013-01-24 | 2023-12-19 | Cardiovalve Ltd. | Partially-covered prosthetic valves |
| US12419633B2 (en) | 2013-02-26 | 2025-09-23 | Edwards Lifesciences Corporation | Devices and methods for percutaneous tricuspid valve repair |
| US11793505B2 (en) | 2013-02-26 | 2023-10-24 | Edwards Lifesciences Corporation | Devices and methods for percutaneous tricuspid valve repair |
| US10918374B2 (en) | 2013-02-26 | 2021-02-16 | Edwards Lifesciences Corporation | Devices and methods for percutaneous tricuspid valve repair |
| US10876104B2 (en) | 2013-03-14 | 2020-12-29 | Translate Bio, Inc. | Methods for purification of messenger RNA |
| US12234446B2 (en) | 2013-03-14 | 2025-02-25 | Translate Bio, Inc. | Methods for purification of messenger RNA |
| US11510937B2 (en) | 2013-03-14 | 2022-11-29 | Translate Bio, Inc. | CFTR MRNA compositions and related methods and uses |
| US10265171B2 (en) | 2013-03-14 | 2019-04-23 | Edwards Lifesciences Corporation | Multi-stranded heat set annuloplasty rings |
| US9687346B2 (en) | 2013-03-14 | 2017-06-27 | Edwards Lifesciences Corporation | Multi-stranded heat set annuloplasty rings |
| US12156981B2 (en) | 2013-03-14 | 2024-12-03 | Edwards Lifesciences Innovation (Israel) Ltd. | Guidewire feeder |
| US12186190B2 (en) | 2013-03-14 | 2025-01-07 | Edwards Lifesciences Corporation | Methods of forming heat set annuloplasty rings |
| US9713626B2 (en) | 2013-03-14 | 2017-07-25 | Rana Therapeutics, Inc. | CFTR mRNA compositions and related methods and uses |
| US11534583B2 (en) | 2013-03-14 | 2022-12-27 | Valtech Cardio Ltd. | Guidewire feeder |
| US11820977B2 (en) | 2013-03-14 | 2023-11-21 | Translate Bio, Inc. | Methods for purification of messenger RNA |
| US9181321B2 (en) | 2013-03-14 | 2015-11-10 | Shire Human Genetic Therapies, Inc. | CFTR mRNA compositions and related methods and uses |
| US11692189B2 (en) | 2013-03-14 | 2023-07-04 | Translate Bio, Inc. | Methods for purification of messenger RNA |
| US9957499B2 (en) | 2013-03-14 | 2018-05-01 | Translate Bio, Inc. | Methods for purification of messenger RNA |
| US10449333B2 (en) | 2013-03-14 | 2019-10-22 | Valtech Cardio, Ltd. | Guidewire feeder |
| US10420791B2 (en) | 2013-03-14 | 2019-09-24 | Translate Bio, Inc. | CFTR MRNA compositions and related methods and uses |
| US11045319B2 (en) | 2013-03-14 | 2021-06-29 | Edwards Lifesciences Corporation | Methods of forming heat set annuloplasty rings |
| US11890194B2 (en) | 2013-03-15 | 2024-02-06 | Edwards Lifesciences Corporation | Translation catheters, systems, and methods of use thereof |
| US10682232B2 (en) | 2013-03-15 | 2020-06-16 | Edwards Lifesciences Corporation | Translation catheters, systems, and methods of use thereof |
| US9315472B2 (en) | 2013-05-01 | 2016-04-19 | Massachusetts Institute Of Technology | 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof |
| US9700413B2 (en) | 2013-08-14 | 2017-07-11 | Sorin Group Italia, S.r.l. | Apparatus and method for chordal replacement |
| US9155622B2 (en) | 2013-08-14 | 2015-10-13 | Sorin Group Italia S.R.L. | Apparatus and method for chordal replacement |
| US10918373B2 (en) | 2013-08-31 | 2021-02-16 | Edwards Lifesciences Corporation | Devices and methods for locating and implanting tissue anchors at mitral valve commissure |
| US12396720B2 (en) | 2013-08-31 | 2025-08-26 | Edwards Lifesciences Corporation | Devices and methods for locating and implanting tissue anchors at mitral valve commissure |
| US11744573B2 (en) | 2013-08-31 | 2023-09-05 | Edwards Lifesciences Corporation | Devices and methods for locating and implanting tissue anchors at mitral valve commissure |
| US9629804B2 (en) | 2013-10-22 | 2017-04-25 | Shire Human Genetic Therapies, Inc. | Lipid formulations for delivery of messenger RNA |
| US11890377B2 (en) | 2013-10-22 | 2024-02-06 | Translate Bio, Inc. | Lipid formulations for delivery of messenger RNA |
| US9522176B2 (en) | 2013-10-22 | 2016-12-20 | Shire Human Genetic Therapies, Inc. | MRNA therapy for phenylketonuria |
| US10052284B2 (en) | 2013-10-22 | 2018-08-21 | Translate Bio, Inc. | Lipid formulations for delivery of messenger RNA |
| US11224642B2 (en) | 2013-10-22 | 2022-01-18 | Translate Bio, Inc. | MRNA therapy for argininosuccinate synthetase deficiency |
| US10493031B2 (en) | 2013-10-22 | 2019-12-03 | Translate Bio, Inc. | Lipid formulations for delivery of messenger RNA |
| US10959953B2 (en) | 2013-10-22 | 2021-03-30 | Translate Bio, Inc. | Lipid formulations for delivery of messenger RNA |
| US11766263B2 (en) | 2013-10-23 | 2023-09-26 | Edwards Lifesciences Innovation (Israel) Ltd. | Anchor magazine |
| US12408918B2 (en) | 2013-10-23 | 2025-09-09 | Edwards Lifesciences Innovation (Israel) Ltd. | Anchor magazine |
| US10299793B2 (en) | 2013-10-23 | 2019-05-28 | Valtech Cardio, Ltd. | Anchor magazine |
| US11065001B2 (en) | 2013-10-23 | 2021-07-20 | Valtech Cardio, Ltd. | Anchor magazine |
| US10166098B2 (en) | 2013-10-25 | 2019-01-01 | Middle Peak Medical, Inc. | Systems and methods for transcatheter treatment of valve regurgitation |
| US11497606B2 (en) | 2013-10-25 | 2022-11-15 | Polares Medical Inc. | Systems and methods for transcatheter treatment of valve regurgitation |
| US12350153B2 (en) | 2013-10-25 | 2025-07-08 | Polares Medical Inc. | Systems and methods for transcatheter treatment of valve regurgitation |
| US11000372B2 (en) | 2013-10-25 | 2021-05-11 | Polares Medical Inc. | Systems and methods for transcatheter treatment of valve regurgitation |
| US9610162B2 (en) | 2013-12-26 | 2017-04-04 | Valtech Cardio, Ltd. | Implantation of flexible implant |
| US10265170B2 (en) | 2013-12-26 | 2019-04-23 | Valtech Cardio, Ltd. | Implantation of flexible implant |
| US10973637B2 (en) | 2013-12-26 | 2021-04-13 | Valtech Cardio, Ltd. | Implantation of flexible implant |
| US11884692B2 (en) | 2014-04-25 | 2024-01-30 | Translate Bio, Inc. | Methods for purification of messenger RNA |
| US12060381B2 (en) | 2014-04-25 | 2024-08-13 | Translate Bio, Inc. | Methods for purification of messenger RNA |
| US10155785B2 (en) | 2014-04-25 | 2018-12-18 | Translate Bio, Inc. | Methods for purification of messenger RNA |
| US11059841B2 (en) | 2014-04-25 | 2021-07-13 | Translate Bio, Inc. | Methods for purification of messenger RNA |
| US9850269B2 (en) | 2014-04-25 | 2017-12-26 | Translate Bio, Inc. | Methods for purification of messenger RNA |
| US10286083B2 (en) | 2014-05-30 | 2019-05-14 | Translate Bio, Inc. | Biodegradable lipids for delivery of nucleic acids |
| US10493166B2 (en) | 2014-05-30 | 2019-12-03 | Translate Bio, Inc. | Biodegradable lipids for delivery of nucleic acids |
| US10022455B2 (en) | 2014-05-30 | 2018-07-17 | Translate Bio, Inc. | Biodegradable lipids for delivery of nucleic acids |
| US10286082B2 (en) | 2014-05-30 | 2019-05-14 | Translate Bio, Inc. | Biodegradable lipids for delivery of nucleic acids |
| US10293057B2 (en) | 2014-05-30 | 2019-05-21 | Translate Bio, Inc. | Biodegradable lipids for delivery of nucleic acids |
| US11433144B2 (en) | 2014-05-30 | 2022-09-06 | Translate Bio, Inc. | Biodegradable lipids for delivery of nucleic acids |
| US10912844B2 (en) | 2014-05-30 | 2021-02-09 | Translate Bio, Inc. | Biodegradable lipids for delivery of nucleic acids |
| US11974921B2 (en) | 2014-06-18 | 2024-05-07 | Polares Medical Inc. | Mitral valve implants for the treatment of valvular regurgitation |
| US10500048B2 (en) | 2014-06-18 | 2019-12-10 | Polares Medical Inc. | Mitral valve implants for the treatment of valvular regurgitation |
| US11622759B2 (en) | 2014-06-24 | 2023-04-11 | Polares Medical Inc. | Systems and methods for anchoring an implant |
| US10138213B2 (en) | 2014-06-24 | 2018-11-27 | Translate Bio, Inc. | Stereochemically enriched compositions for delivery of nucleic acids |
| US11104652B2 (en) | 2014-06-24 | 2021-08-31 | Translate Bio, Inc. | Stereochemically enriched compositions for delivery of nucleic acids |
| US10251635B2 (en) | 2014-06-24 | 2019-04-09 | Middle Peak Medical, Inc. | Systems and methods for anchoring an implant |
| US9840479B2 (en) | 2014-07-02 | 2017-12-12 | Massachusetts Institute Of Technology | Polyamine-fatty acid derived lipidoids and uses thereof |
| US12053380B2 (en) | 2014-07-30 | 2024-08-06 | Cardiovalve Ltd. | Anchoring of a prosthetic valve |
| US20170224473A1 (en)* | 2014-10-13 | 2017-08-10 | Jack Kanouzi | Implantable prosthetic ring for correcting and preventing breast areola asymmetry |
| US11071628B2 (en) | 2014-10-14 | 2021-07-27 | Valtech Cardio, Ltd. | Leaflet-restraining techniques |
| US10195030B2 (en) | 2014-10-14 | 2019-02-05 | Valtech Cardio, Ltd. | Leaflet-restraining techniques |
| US20170224477A1 (en)* | 2014-10-16 | 2017-08-10 | Jacques Seguin | Intervalvular implant for a mitral valve |
| US10639154B2 (en)* | 2014-10-16 | 2020-05-05 | Jacques Seguin | Intervalvular implant for a mitral valve |
| US20160120643A1 (en)* | 2014-11-05 | 2016-05-05 | Tara Kupumbati | Transcatheter cardiac valve prosthetic |
| US11801135B2 (en) | 2015-02-05 | 2023-10-31 | Cardiovalve Ltd. | Techniques for deployment of a prosthetic valve |
| US12396851B2 (en) | 2015-02-05 | 2025-08-26 | Cardiovalve Ltd. | Prosthetic valve with arms and flanges |
| US10925610B2 (en) | 2015-03-05 | 2021-02-23 | Edwards Lifesciences Corporation | Devices for treating paravalvular leakage and methods use thereof |
| US10980529B2 (en) | 2015-03-05 | 2021-04-20 | Ancora Heart, Inc. | Devices and methods of visualizing and determining depth of penetration in cardiac tissue |
| US12102316B2 (en) | 2015-03-05 | 2024-10-01 | Ancora Heart, Inc. | Devices and methods of visualizing and determining depth of penetration in cardiac tissue |
| US10058321B2 (en) | 2015-03-05 | 2018-08-28 | Ancora Heart, Inc. | Devices and methods of visualizing and determining depth of penetration in cardiac tissue |
| US11020227B2 (en) | 2015-04-30 | 2021-06-01 | Valtech Cardio, Ltd. | Annuloplasty technologies |
| US12138164B2 (en) | 2015-04-30 | 2024-11-12 | Edwards Lifesciences Innovation (Israel) Ltd. | Annuloplasty technologies |
| US10765514B2 (en) | 2015-04-30 | 2020-09-08 | Valtech Cardio, Ltd. | Annuloplasty technologies |
| US11964112B2 (en) | 2015-05-12 | 2024-04-23 | Ancora Heart, Inc. | Device and method for releasing catheters from cardiac structures |
| US10980973B2 (en) | 2015-05-12 | 2021-04-20 | Ancora Heart, Inc. | Device and method for releasing catheters from cardiac structures |
| US11471280B2 (en) | 2015-06-09 | 2022-10-18 | Edwards Lifesciences, Llc | Asymmetric mitral annuloplasty band |
| US10314707B2 (en) | 2015-06-09 | 2019-06-11 | Edwards Lifesciences, Llc | Asymmetric mitral annuloplasty band |
| US11938027B2 (en) | 2015-06-09 | 2024-03-26 | Edwards Lifesciences, Llc | Asymmetric mitral annuloplasty band |
| US12350154B2 (en) | 2015-06-09 | 2025-07-08 | Edwards Lifesciences, Llc | Method for implanting an asymmetric mitral annuloplasty band |
| US11324593B2 (en) | 2015-06-09 | 2022-05-10 | Edwards Lifesciences, Llc | Asymmetric mitral annuloplasty band |
| US10695170B2 (en) | 2015-07-02 | 2020-06-30 | Edwards Lifesciences Corporation | Hybrid heart valves adapted for post-implant expansion |
| US12357455B2 (en) | 2015-07-02 | 2025-07-15 | Edwards Lifesciences Corporation | Hybrid heart valves |
| US11690714B2 (en) | 2015-07-02 | 2023-07-04 | Edwards Lifesciences Corporation | Hybrid heart valves adapted for post-implant expansion |
| US10456246B2 (en) | 2015-07-02 | 2019-10-29 | Edwards Lifesciences Corporation | Integrated hybrid heart valves |
| US11654020B2 (en) | 2015-07-02 | 2023-05-23 | Edwards Lifesciences Corporation | Hybrid heart valves |
| US10376365B2 (en) | 2015-11-06 | 2019-08-13 | Middle Peak Medical, Inc. | Device, system, and method for transcatheter treatment of valvular regurgitation |
| US11160656B2 (en) | 2015-11-06 | 2021-11-02 | Polares Medical Inc. | Device, system, and method for transcatheter treatment of valvular regurgitation |
| US9592121B1 (en) | 2015-11-06 | 2017-03-14 | Middle Peak Medical, Inc. | Device, system, and method for transcatheter treatment of valvular regurgitation |
| US11890193B2 (en) | 2015-12-30 | 2024-02-06 | Edwards Lifesciences Corporation | System and method for reducing tricuspid regurgitation |
| US11660192B2 (en) | 2015-12-30 | 2023-05-30 | Edwards Lifesciences Corporation | System and method for reshaping heart |
| US10751182B2 (en) | 2015-12-30 | 2020-08-25 | Edwards Lifesciences Corporation | System and method for reshaping right heart |
| US10828160B2 (en) | 2015-12-30 | 2020-11-10 | Edwards Lifesciences Corporation | System and method for reducing tricuspid regurgitation |
| US11937795B2 (en) | 2016-02-16 | 2024-03-26 | Cardiovalve Ltd. | Techniques for providing a replacement valve and transseptal communication |
| US11540835B2 (en) | 2016-05-26 | 2023-01-03 | Edwards Lifesciences Corporation | Method and system for closing left atrial appendage |
| US10702274B2 (en) | 2016-05-26 | 2020-07-07 | Edwards Lifesciences Corporation | Method and system for closing left atrial appendage |
| US10959845B2 (en) | 2016-07-08 | 2021-03-30 | Valtech Cardio, Ltd. | Adjustable annuloplasty device with alternating peaks and troughs |
| US12102533B2 (en) | 2016-07-08 | 2024-10-01 | Edwards Lifesciences Innovation (Israel) Ltd. | Adjustable annuloplasty device with alternating peaks and troughs |
| US10226342B2 (en) | 2016-07-08 | 2019-03-12 | Valtech Cardio, Ltd. | Adjustable annuloplasty device with alternating peaks and troughs |
| US12053379B2 (en) | 2016-08-01 | 2024-08-06 | Cardiovalve Ltd. | Minimally-invasive delivery systems |
| US11779458B2 (en) | 2016-08-10 | 2023-10-10 | Cardiovalve Ltd. | Prosthetic valve with leaflet connectors |
| US11717404B2 (en) | 2016-11-03 | 2023-08-08 | Edwards Lifesciences Corporation | Prosthetic mitral valve holders |
| USD1043986S1 (en) | 2016-11-03 | 2024-09-24 | Edwards Lifesciences Corporation | Prosthetic valve and holder |
| USD960372S1 (en) | 2016-11-03 | 2022-08-09 | Edwards Lifesciences Corporation | Prosthetic valve and holder |
| US10722356B2 (en) | 2016-11-03 | 2020-07-28 | Edwards Lifesciences Corporation | Prosthetic mitral valve holders |
| USD933229S1 (en) | 2016-11-03 | 2021-10-12 | Edwards Lifesciences Corporation | Prosthetic valve and holder |
| US10667914B2 (en) | 2016-11-18 | 2020-06-02 | Ancora Heart, Inc. | Myocardial implant load sharing device and methods to promote LV function |
| US12257151B2 (en) | 2016-11-18 | 2025-03-25 | Ancora Heart, Inc. | Myocardial implant load sharing device and methods to promote LV function |
| US11253605B2 (en) | 2017-02-27 | 2022-02-22 | Translate Bio, Inc. | Codon-optimized CFTR MRNA |
| US11534302B2 (en) | 2017-03-13 | 2022-12-27 | Polares Medical Inc. | Device, system, and method for transcatheter treatment of valvular regurgitation |
| US11298229B2 (en) | 2017-03-13 | 2022-04-12 | Polares Medical Inc. | Device, system, and method for transcatheter treatment of valvular regurgitation |
| US10478303B2 (en) | 2017-03-13 | 2019-11-19 | Polares Medical Inc. | Device, system, and method for transcatheter treatment of valvular regurgitation |
| US10123874B2 (en) | 2017-03-13 | 2018-11-13 | Middle Peak Medical, Inc. | Device, system, and method for transcatheter treatment of valvular regurgitation |
| US12285336B2 (en) | 2017-03-13 | 2025-04-29 | Polares Medical Inc. | Device, system, and method for transcatheter treatment of valvular regurgitation |
| US10702386B2 (en) | 2017-03-13 | 2020-07-07 | Polares Medical Inc. | Device, system, and method for transcatheter treatment of valvular regurgitation |
| US10653524B2 (en) | 2017-03-13 | 2020-05-19 | Polares Medical Inc. | Device, system, and method for transcatheter treatment of valvular regurgitation |
| US12295845B2 (en) | 2017-03-13 | 2025-05-13 | Polares Medical Inc. | Device, system, and method for transcatheter treatment of valvular regurgitation |
| US12419747B2 (en) | 2017-03-13 | 2025-09-23 | Polares Medical Inc. | Device, system, and method for transcatheter treatment of valvular regurgitation |
| US11672659B2 (en) | 2017-03-13 | 2023-06-13 | Polares Medical Inc. | Device, system, and method for transcatheter treatment of valvular regurgitation |
| US11883611B2 (en) | 2017-04-18 | 2024-01-30 | Edwards Lifesciences Corporation | Catheter system with linear actuation control mechanism |
| US11045627B2 (en) | 2017-04-18 | 2021-06-29 | Edwards Lifesciences Corporation | Catheter system with linear actuation control mechanism |
| US11173190B2 (en) | 2017-05-16 | 2021-11-16 | Translate Bio, Inc. | Treatment of cystic fibrosis by delivery of codon-optimized mRNA encoding CFTR |
| US12090048B2 (en) | 2017-08-03 | 2024-09-17 | Cardiovalve Ltd. | Prosthetic heart valve |
| US12029646B2 (en) | 2017-08-03 | 2024-07-09 | Cardiovalve Ltd. | Prosthetic heart valve |
| US12064347B2 (en) | 2017-08-03 | 2024-08-20 | Cardiovalve Ltd. | Prosthetic heart valve |
| US12232958B2 (en) | 2017-08-03 | 2025-02-25 | Cardiovalve Ltd. | Prosthetic heart valve |
| US10835221B2 (en) | 2017-11-02 | 2020-11-17 | Valtech Cardio, Ltd. | Implant-cinching devices and systems |
| US11832784B2 (en) | 2017-11-02 | 2023-12-05 | Edwards Lifesciences Innovation (Israel) Ltd. | Implant-cinching devices and systems |
| US11135062B2 (en) | 2017-11-20 | 2021-10-05 | Valtech Cardio Ltd. | Cinching of dilated heart muscle |
| US12364605B2 (en) | 2017-11-20 | 2025-07-22 | Edwards Lifesciences Innovation (Israel) Ltd. | Cinching of dilated heart muscle |
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| US11554015B2 (en) | 2018-07-30 | 2023-01-17 | Edwards Lifesciences Corporation | Minimally-invasive low strain annuloplasty ring |
| US12167964B2 (en) | 2018-07-30 | 2024-12-17 | Edwards Lifesciences Corporation | Minimally-invasive low strain annuloplasty ring |
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| US11951006B2 (en) | 2019-12-16 | 2024-04-09 | Edwards Lifesciences Corporation | Valve holder assembly with suture looping protection |
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| US12357459B2 (en) | 2020-12-03 | 2025-07-15 | Cardiovalve Ltd. | Transluminal delivery system |
| US11464634B2 (en) | 2020-12-16 | 2022-10-11 | Polares Medical Inc. | Device, system, and method for transcatheter treatment of valvular regurgitation with secondary anchors |
| US11759321B2 (en) | 2021-06-25 | 2023-09-19 | Polares Medical Inc. | Device, system, and method for transcatheter treatment of valvular regurgitation |
| US12440648B2 (en) | 2022-02-25 | 2025-10-14 | Edwards Lifesciences Innovation (Israel) Ltd. | Low-profile steerable catheter |
| US12440330B2 (en) | 2023-08-04 | 2025-10-14 | Edwards Lifesciences Corporation | Prosthetic mitral valve holders |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2005112B2 (en) | 1973-08-02 |
| SU365053A3 (en) | 1972-12-28 |
| JPS504999B1 (en) | 1975-02-26 |
| DE2005112A1 (en) | 1970-08-27 |
| IL33838A (en) | 1974-03-14 |
| NL143127B (en) | 1974-09-16 |
| BE745427A (en) | 1970-08-03 |
| CS163762B2 (en) | 1975-11-07 |
| LU60294A1 (en) | 1970-08-04 |
| SE357140B (en) | 1973-06-18 |
| DE2005112C3 (en) | 1974-02-28 |
| NO123299B (en) | 1971-10-25 |
| IL33838A0 (en) | 1970-04-20 |
| CH508395A (en) | 1971-06-15 |
| NL7001136A (en) | 1970-08-06 |
| CA930503A (en) | 1973-07-24 |
| GB1293014A (en) | 1972-10-18 |
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