US3598122A - Bandage for administering drugs - Google Patents
Bandage for administering drugsDownload PDFInfo
- Publication number
- US3598122A US3598122AUS812116AUS3598122DAUS3598122AUS 3598122 AUS3598122 AUS 3598122AUS 812116 AUS812116 AUS 812116AUS 3598122D AUS3598122D AUS 3598122DAUS 3598122 AUS3598122 AUS 3598122A
- Authority
- US
- United States
- Prior art keywords
- bandage
- reservoir layer
- release rate
- systemically active
- rate controlling
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/58—Adhesives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Anesthesiology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Materials Engineering (AREA)
- Medical Informatics (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Preparation (AREA)
Abstract
Claims (15)
1. A medical bandage for use in the continuous administration to circulation of controlled quantities of systemically active drugs over a prolonged period of time by absorption through the external body skin or mucosa, said bandage comprising a sandwich including (1) a backing member; (2) a discrete, middle reservoir layer containing a systemically active drug, which reservoir layer is comprised of systemically active drug formulation confined within a wall member, said wall member being formed from drug release rate controlling material to continuously meter the flow of drug from the said reservoir to the skin or mucosa at a controlled and predetermined rate over a prolonged period of time; and (3) a surface of a pressure-sensitive adhesive adapted for contact with the skin or mucosa of a patient.
2. The bandage as defined by claim 1, wherein the reservoir layer (2) is comprised of a walled container having an interior chamber containing the systemically active drug formulation.
3. The bandage as defined by claim 1, wherein the reservoir layer (2) is comprised of a matrix of the drug release rate controlling wall material, said matrix having the systemically active drug formulation distributed therethrough.
4. The bandage as defined by claim 1, wherein the systemically active drug formulation is soluble in the drug release rate controlling material.
5. The bandage as defined by claim 1, wherein the pressure-sensitive adhesive is permeable to passage of the systemically active drug formulation.
6. The bandage as defined by claim 1, wherein the drug formulation comprises a pharmacologically acceptable solvent.
7. The bandages as defined by claim 1, further comprising a solubility membrane (4) interposed between said reservoir layer (2) and said surface of pressure-sensitive adhesive (3).
8. The bandage as defined by claim 1, wherein said drug release rate controlling material is silicone rubber.
9. The bandage as defined by claim 1, wherein said drug release rate controlling material is a hydrophilic polymer of an ester of an olefinic acid.
10. The bandage as defined by claim 1, wherein at least that portion of the wall member comprising the reservoir layer (2) which is adapted to be brought contiguous the skin as mucosa is formed from the drug release rate controlling material.
11. The bandage as defined by claim 1, wherein the wall member comprising the reservoir layer (2) consists of drug release rate controlling material.
12. The bandage as defined by claim 1, wherein the outer surface of the wall member comprising the reservoir layer (2) also defines the said backing member (1).
13. The bandage as defined by claim 1, wherein the pressure-sensitive adhesive is adapted to provide a liquidtight adhesive seal between the skin or mucosa and the bandage.
14. The bandage as defined by claim 1, wherein the surface of a pressure-sensitive adhesive (3) is covered with a protective release coating (5).
15. The bandage as defined by claim 1, wherein the outer surface of the backing member (1) is coated with a low-adhesion backsize (6).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81211669A | 1969-04-01 | 1969-04-01 | |
| ZA714095AZA714095B (en) | 1969-04-01 | 1971-06-22 | Bandage for administering drugs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| US3598122Atrue US3598122A (en) | 1971-08-10 |
| US3598122B1 US3598122B1 (en) | 1982-11-23 |
Family
ID=27123569
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US812116AExpired - LifetimeUS3598122A (en) | 1969-04-01 | 1969-04-01 | Bandage for administering drugs |
Country Status (2)
| Country | Link |
|---|---|
| US (1) | US3598122A (en) |
| ZA (1) | ZA714095B (en) |
Cited By (448)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3710795A (en)* | 1970-09-29 | 1973-01-16 | Alza Corp | Drug-delivery device with stretched, rate-controlling membrane |
| US3731683A (en)* | 1971-06-04 | 1973-05-08 | Alza Corp | Bandage for the controlled metering of topical drugs to the skin |
| US3742951A (en)* | 1971-08-09 | 1973-07-03 | Alza Corp | Bandage for controlled release of vasodilators |
| US3797494A (en)* | 1969-04-01 | 1974-03-19 | Alza Corp | Bandage for the administration of drug by controlled metering through microporous materials |
| US3807398A (en)* | 1972-09-19 | 1974-04-30 | B Grucza | Ocular implant |
| US3854480A (en)* | 1969-04-01 | 1974-12-17 | Alza Corp | Drug-delivery system |
| US3896819A (en)* | 1969-04-01 | 1975-07-29 | Alejandro Zaffaroni | IUD having a replenishing drug reservoir |
| US3951622A (en)* | 1974-12-04 | 1976-04-20 | Wilk Immanuel J | Time release perfume method and device |
| US3960150A (en)* | 1971-09-09 | 1976-06-01 | Alza Corporation | Bioerodible ocular device |
| US3961628A (en)* | 1974-04-10 | 1976-06-08 | Alza Corporation | Ocular drug dispensing system |
| US3964482A (en)* | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
| US3981303A (en)* | 1971-09-09 | 1976-09-21 | Alza Corporation | Bioerodible ocular device |
| US3986510A (en)* | 1971-09-09 | 1976-10-19 | Alza Corporation | Bioerodible ocular device |
| US3993071A (en)* | 1971-09-09 | 1976-11-23 | Alza Corporation | Bioerodible ocular device |
| US3993073A (en)* | 1969-04-01 | 1976-11-23 | Alza Corporation | Novel drug delivery device |
| US3993072A (en)* | 1974-08-28 | 1976-11-23 | Alza Corporation | Microporous drug delivery device |
| US3996934A (en)* | 1971-08-09 | 1976-12-14 | Alza Corporation | Medical bandage |
| DE2647581A1 (en)* | 1976-10-21 | 1978-04-27 | Henkel Kgaa | BLISTER PACK |
| US4191743A (en)* | 1976-11-02 | 1980-03-04 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Antibacterial wound dressing |
| US4201211A (en)* | 1977-07-12 | 1980-05-06 | Alza Corporation | Therapeutic system for administering clonidine transdermally |
| US4286592A (en)* | 1980-02-04 | 1981-09-01 | Alza Corporation | Therapeutic system for administering drugs to the skin |
| US4336243A (en)* | 1980-08-11 | 1982-06-22 | G. D. Searle & Co. | Transdermal nitroglycerin pad |
| EP0065370A1 (en)* | 1981-05-02 | 1982-11-24 | Smith and Nephew Associated Companies p.l.c. | Sterile dressing and preparation thereof |
| FR2508318A1 (en)* | 1981-06-29 | 1982-12-31 | Alza Corp | BANDAGE FOR THE ADMINISTRATION OF A PHARMACEUTICAL SUBSTANCE |
| US4435180A (en) | 1982-05-25 | 1984-03-06 | Alza Corporation | Elastomeric active agent delivery system and method of use |
| US4460371A (en)* | 1981-11-24 | 1984-07-17 | Dennison Manufacturing Company | Silicone pressure sensitive adhesive and uses |
| DE3500508A1 (en)* | 1984-03-05 | 1985-09-12 | Nitto Electric Industrial Co., Ltd., Ibaraki, Osaka | PREPARATION FOR PERCUTANEOUS ADMINISTRATION OF MEDICINAL PRODUCTS AND METHOD FOR THE PRODUCTION THEREOF |
| FR2562800A1 (en)* | 1984-04-11 | 1985-10-18 | Fournier Laboratoires | Device for percutaneous administration of medicaments |
| US4563184A (en)* | 1983-10-17 | 1986-01-07 | Bernard Korol | Synthetic resin wound dressing and method of treatment using same |
| WO1986000532A1 (en)* | 1984-07-07 | 1986-01-30 | Flexcon Company, Inc. | Silicone pressure sensitive adhesive and uses |
| US4568343A (en)* | 1984-10-09 | 1986-02-04 | Alza Corporation | Skin permeation enhancer compositions |
| US4594240A (en)* | 1982-09-10 | 1986-06-10 | Teikoku Seiyaku Kabushiki Kaisha | Sheet-shape adhesive preparation |
| US4597961A (en)* | 1985-01-23 | 1986-07-01 | Etscorn Frank T | Transcutaneous application of nicotine |
| US4608249A (en)* | 1982-11-02 | 1986-08-26 | Nitto Electric Industrial Co., Ltd. | Hydrophilic therapeutic material |
| US4614787A (en)* | 1984-11-13 | 1986-09-30 | Thermedics, Inc. | Drug dispensing wound dressing |
| US4615697A (en)* | 1983-11-14 | 1986-10-07 | Bio-Mimetics, Inc. | Bioadhesive compositions and methods of treatment therewith |
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| US4649075A (en)* | 1984-08-09 | 1987-03-10 | Leonora Jost | Transdermal and transmucosal vortexed foam devices and the method of making |
| US4666441A (en)* | 1985-12-17 | 1987-05-19 | Ciba-Geigy Corporation | Multicompartmentalized transdermal patches |
| WO1987003477A1 (en)* | 1985-12-12 | 1987-06-18 | Flexcon Company, Inc. | Transdermal methods and adhesives |
| EP0236266A1 (en)* | 1986-02-14 | 1987-09-09 | Ciba-Geigy Ag | Dermal and transdermal therapeutic system having a discontinuous-pattern adhesive layer and method of manufacturing thereof |
| US4704282A (en)* | 1984-06-29 | 1987-11-03 | Alza Corporation | Transdermal therapeutic system having improved delivery characteristics |
| EP0249343A1 (en)* | 1986-06-13 | 1987-12-16 | Alza Corporation | Moisture activation of transdermal drug delivery system |
| GB2191943A (en)* | 1986-06-03 | 1987-12-31 | Smith & Nephew Ass | Topical drug delivery device |
| US4725439A (en)* | 1984-06-29 | 1988-02-16 | Alza Corporation | Transdermal drug delivery device |
| US4727868A (en)* | 1984-11-13 | 1988-03-01 | Thermedics, Inc. | Anisotropic wound dressing |
| EP0259136A2 (en) | 1986-09-02 | 1988-03-09 | Alza Corporation | Transdermal delivery device having a rate controlling adhesive |
| US4738848A (en)* | 1985-06-04 | 1988-04-19 | Nitto Electric Industrial Co., Ltd. | Anti-inflammatory analgesic adhesive preparation |
| US4743249A (en)* | 1986-02-14 | 1988-05-10 | Ciba-Geigy Corp. | Dermal and transdermal patches having a discontinuous pattern adhesive layer |
| US4746515A (en)* | 1987-02-26 | 1988-05-24 | Alza Corporation | Skin permeation enhancer compositions using glycerol monolaurate |
| FR2607003A1 (en)* | 1986-11-20 | 1988-05-27 | Marchandise Jean | Homeopathic skin card |
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Also Published As
| Publication number | Publication date |
|---|---|
| US3598122B1 (en) | 1982-11-23 |
| ZA714095B (en) | 1972-02-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Reexamination certificate first reexamination |