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US3368558A - Two compartment cartridge - Google Patents

Two compartment cartridge
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Publication number
US3368558A
US3368558AUS391836AUS39183664AUS3368558AUS 3368558 AUS3368558 AUS 3368558AUS 391836 AUS391836 AUS 391836AUS 39183664 AUS39183664 AUS 39183664AUS 3368558 AUS3368558 AUS 3368558A
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United States
Prior art keywords
needle
washer
compartment
wall
stopper
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Expired - Lifetime
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US391836A
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Stanley J Sarnoff
John W Balenger
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Sarnoff Corp
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Sarnoff Corp
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Publication date
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Priority to US391836ApriorityCriticalpatent/US3368558A/en
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Publication of US3368558ApublicationCriticalpatent/US3368558A/en
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Feb. 13, 1968 5. J. SARNOFF ET AL 3,368,558
TWO COMPARTMENT CARTRIDGE Filed Aug. 21, 1964 r INVENTORS Sfan/ew J. Sarnoff lll John W fialehger BY ATTORNEYS United States Patent ()fiice 3,368,558 TWO CUMPARTMENT CARTRIDGE Stanley J. Sarnofi, 7801 Woodmont Avc., Montgomery County, Md. 20014, and John W. Balenger, Montgomery County, Md.; said Balenger assignor to said Sarnoff Filed Aug. 21, 1964, Ser. No. 391,836 2 Claims. (Cl. 128218) ABSTRACT OF THE DISCLOSURE In a cartridge wherein medicament is stored in one compartment thereof and a double pointed needle in another compartment, means are provided to prevent the needle from piercing a wall separating the needle from the medicament compartment prior to full emergence of the opposite end of the needle through a wall separating the needle compartment with the ambient atmosphere.
This invention relates to a two compartment cartridge for use in a hypodermic syringe. More specifically, it relates to a two compartment cartridge wherein a hollow needle is stored in one of the compartments and a medication is stored in the other compartment.
It is an object of this invention to provide a positive means for ensuring that the needle be advanced from its storage position in the compartment to an operative position with the forward end of the needle exterior of the compartment before the rear end of the needle is brought into communication with the medicament in the rear compartment.
Other objects will become apparent after consideration of the following specification when taken in conjunction with the accompanying drawing in which:
FIG. 1 is a perspective view of the cartridge in unoperated condition, that is, with the needle in storage position.
FIG. 2 is an enlarged cross-sectional view of the cartridge, parts being broken away, in the storage position of the needle.
FIG. 3 is a similar view with the front end of the needle projected through the wall of the storage compartment and the needle about to penetrate into the medicament compartment.
FIG. 4 is a similar view with the rear end of the needle within the medicament compartment, and
FIG. 5 is an enlarged view of a portion of the advancing means.
Referring to the drawing in greater detail, at is indicated a cartridge casing in the form of a cylinder made of metal, plastic or glass, and here shown as of glass, within which is arear medicament compartment 12 and a hollow needlefront storage compartment 14. The two compartments are separated by atranslatable wall 16, preferably of rubber, the medicament compartment being closed off by apiston 18, also preferably of rubber. Amedicament 19, as a fluid medicament, is located in thecompartment 12.
Within the front compartment is a hollow needle with a bevelledrear end 22 and a bevelledfront end 24. The rear end of this needle normally rests in arecess 26 inwall 16 with its bevelled end close to a comparatively thin septum ormembrane 28 between therecess 26 and asecond registering recess 29. The forward end of the front compartment is closed off by astopper 30, also preferably of rubber, the stopper being provided with arecess 32 accommodating the forward bevelled end of the needle. Theclosure 34 at the front end of the stopper is a comparatively thin membrane and it may project slightly be- 3,368,558 Patented Feb. 13, 1968 yond the outer surface of the stopper. The stopper is tightly frictionally held in thecasing 10.
When pressure is applied to thepiston 18, thewall 16 will be advanced due to the transmission of force through theliquid medicament 14. In the absence of control devices such as will be described, the bevelled ends of the needle would penetrate themembranes 28 and 34 in an order detremined by the sharpness of the bevelled ends of the needles, the thickness and density of the membranes, and the quality of the membranes. A further variable exists in that continued contact of the medicament with therubber septum 28 may cause softening and deterioration of the rubber. Because of all of these variables, even though it may have been intended to have themembrane 34 pierced before theseptum 28 was pierced, there was no certainty that this order of piercing would take place.
However, by interposing a releasable blocking device between thetranslatable wall 16 and needle it is possible to ensure the piercing of themembrane 34 and extrusion of the forward needle end beyond thestopper 30 prior to establishing communication between the medicament containing chamber and the lumen of the needle.
A description of the blocking device follows: Fixed to and surrounding the outer periphery of the needle, and at a slight distance from the diaphragm is anannular washer 36. Embedded in the face of thewall 16, as by being frictionally held in a recess in the wall, is awasher 38 freely surrounding the needle. This washer has one or morepliable fingers 40 extending toward and engaging the rear face of thewasher 36. Any number of such fingers may be employed although three fingers equally spaced circumferen'tially of thewasher 38 is preferred. Each finger has atoe portion 42 having a face parallel to the rear face of the washer bearing against thewasher 36 and aninclined portion 44 forming a cam end of the finger. The toe portion has abevelled edge 46 for a purpose which will be disclosed.
While not necessary, it is preferred to supply ametal washer 48 loosely surrounding the needle and serving to center the forward end of the needle to ensure penetration of thestopper 30 at the proper area. In a preferred form of the washer it is made with a rear conical surface rather than a plane surface to better act as a camming surface, as will be explained. In operation, when pressure is applied to thepiston 18, as by thrust of a plunger rod of a syringe against the piston, thewall 16 is translated through the intermediary of theliquid link 19. Thereupon thetoe 42 or thetoes 42 thrust on the needle mountedwasher 36 and drive the washer and afiixed needle through themembrane 34 of thestopper 30. The needle is thrust through the stopper by reason of the coupling action of the fingers until thecam portion 44 ofpliable finger 40 engages thestopper 30 or thewasher 48 where the latter is used. Since this end of the finger extends only slightly below thewasher 36,washer 36 is now close towasher 48. The free end of each of the fingers, on further downward movement of thewall 16, slides along the rear surface of thewasher 48 and radially away from the needle thereby freeing the toe from thewasher 36 thecam portion 46 assisting such action. Now that the block between the needle andwall 16 is removed, thewall 16 slides along the length of the needle, causing the needle to pierce theseptum 28. Continued movement of the piston, under the influence exerted by pressure on thepiston 18 andliquid medicament 19 causes the forward face of thewasher 38 to engage and drive thewasher 36 into firm engagement with thewasher 48, thereby preventing rearward movement of theneedle 20. Also, medicament is now ejected from the needle.
Having thus described the invention, what is claimed is:
l. A cartridge comprising a casing, a piston adjacent one end of the casing, a translatable wall within the casing intermediate the ends of the casing, and a stopper at the other end of the casing, a medicament in a first compartment formed in the casing between the piston and translatable wall, a hollow needle in a second compartment formed in the casing between the intermediate wall and the stopper, and a mechanical drive connection between the needle and translatable wall having a part driven by the Wall and a part fixed to the needle to cause the needle to penetrate the stopper on displacement of the piston, and means engaged by a part of the mechanical connection in its displacement within the casing to uncouple the connection whereby the wall moves relative to the needle and the needle subsequently pierces the wall, the fiuid then being ejected through the needle, said drive connection comprising a washer afiixed to the needle and a pliable finger carried by the translatable Wall engaging the washer, the finger extending angularly in a direction toward the stopper and away from the needle, and the means for uncoupling the connection including a second Washer adjacent the stopper, the second washer being engaged by the end of the finger and effecting radial displacement of the end of the finger away from the needle.
2. The structure of claim 1 wherein the rear face of the "washer is conical with the conical apex of the Washer surrounding the needle.
References Cited UNITED STATES PATENTS 1,767,304 6/1930 Morton 128220 2,408,323 9/1946 Lockhart 128220 2,460,039 1/1949 Scherer 128218 RICHARD A. GAUDET, Primary Examiner.
D. L. BAKER, Assistant Examiner.
US391836A1964-08-211964-08-21Two compartment cartridgeExpired - LifetimeUS3368558A (en)

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US391836AUS3368558A (en)1964-08-211964-08-21Two compartment cartridge

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US391836AUS3368558A (en)1964-08-211964-08-21Two compartment cartridge

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Cited By (29)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US3583399A (en)*1968-09-031971-06-08Astra Chem LtdSelf-aspirating syringe
US3636950A (en)*1968-11-141972-01-25American Home ProdDisposable cartridge for admixing two components of injectable medicament
US4553962A (en)*1983-01-171985-11-19Brunet Jean LouisMedical syringe
US4643721A (en)*1984-11-201987-02-17Poutrait-MorinMultiple compartment ampule for automatic hypodermic syringes
US4747829A (en)*1987-01-211988-05-31E. R. Squibb & Sons, Inc.Pre-filled syringe
EP0276522A1 (en)*1986-01-131988-08-03Eldon E. LarsonLubricating device
US4929237A (en)*1988-11-071990-05-29David MedwayHypodermic needle protection device
US4932944A (en)*1988-03-091990-06-12The University Of Virginia Alumni Patents FoundationIntravenous port injection and connector system
US4988339A (en)*1988-12-301991-01-29Vadher Dinesh LRetractable needle/syringe devices for blood collection, catheterization, and medicinal injection procedures
USD321472S (en)1988-12-271991-11-12Evans Donald JSyringe container
US5102393A (en)*1989-07-171992-04-07Survival Technology, Inc.Autoinjector converted from intramuscular to subcutaneous mode of injection
EP0616541A4 (en)*1992-10-051995-04-19Senetek Plc DRUG INJECTORS AND METHODS.
WO1995011712A1 (en)*1993-10-261995-05-04Eastland Technology Australia Pty. Ltd.Syringe or like parenteral device
EP0598055A4 (en)*1991-08-061995-05-24Senetek Plc MEDICAMENT INJECTOR AND METHOD.
US5562635A (en)*1992-04-211996-10-08Eastland Technology Australia Pty LtdParenteral device
WO1997002855A1 (en)*1995-07-121997-01-30Societe D'etudes Et D'applications Techniques - SedatSelf-protected injection syringe
US5709668A (en)*1991-01-161998-01-20Senetek PlcAutomatic medicament injector employing non-coring needle
US5993418A (en)*1998-02-241999-11-30Medisys Technologies, Inc.Safety syringe
US6450216B1 (en)*1998-10-262002-09-17Valois, S.A.Reservoir provided with a device for closing and/or filling and device for dispensing a fluid product comprising same
US6626863B1 (en)2000-11-222003-09-30Nusaf, L.L.C.Safety syringe
US20050029288A1 (en)*2001-11-152005-02-10Frederic HeldtFluid product dispensing device
WO2010100244A1 (en)*2009-03-062010-09-10Sanofi-Aventis Deutschland GmbhSeal member for syringe with retractable needle
JP2013542022A (en)*2010-11-032013-11-21サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Medicinal module with a deformable membrane
US20150335827A1 (en)*2012-12-192015-11-26Novo Nordisk A/SA Needle Device
US20160166765A1 (en)*2011-10-142016-06-16Amgen Inc.Injector and method of assembly
US20190060569A1 (en)*2017-08-302019-02-28Pirouette Medical LLCCompact auto-injector
US10850037B2 (en)2013-03-222020-12-01Amgen Inc.Injector and method of assembly
US11097055B2 (en)2013-10-242021-08-24Amgen Inc.Injector and method of assembly
US20220379044A1 (en)*2019-09-202022-12-01Meiragtx Therapeutics, Inc.Injection Systems and Methods of Their Use

Citations (3)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US1767304A (en)*1927-12-301930-06-24Henry S MortonInjection apparatus
US2408323A (en)*1943-06-101946-09-24Margaret L LockhartHypodermic syringe
US2460039A (en)*1944-04-141949-01-25Scherer Corp R PHypodermic syringe

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US1767304A (en)*1927-12-301930-06-24Henry S MortonInjection apparatus
US2408323A (en)*1943-06-101946-09-24Margaret L LockhartHypodermic syringe
US2460039A (en)*1944-04-141949-01-25Scherer Corp R PHypodermic syringe

Cited By (58)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US3583399A (en)*1968-09-031971-06-08Astra Chem LtdSelf-aspirating syringe
US3636950A (en)*1968-11-141972-01-25American Home ProdDisposable cartridge for admixing two components of injectable medicament
US4553962A (en)*1983-01-171985-11-19Brunet Jean LouisMedical syringe
US4643721A (en)*1984-11-201987-02-17Poutrait-MorinMultiple compartment ampule for automatic hypodermic syringes
EP0276522A1 (en)*1986-01-131988-08-03Eldon E. LarsonLubricating device
US4747829A (en)*1987-01-211988-05-31E. R. Squibb & Sons, Inc.Pre-filled syringe
EP0276160A3 (en)*1987-01-211988-10-05Squibb & Sons IncPre-filled syringe
US4932944A (en)*1988-03-091990-06-12The University Of Virginia Alumni Patents FoundationIntravenous port injection and connector system
US4929237A (en)*1988-11-071990-05-29David MedwayHypodermic needle protection device
WO1991018634A1 (en)*1988-11-071991-12-12David Charles MedwayHypodermic needle protection device
USD321472S (en)1988-12-271991-11-12Evans Donald JSyringe container
US4988339A (en)*1988-12-301991-01-29Vadher Dinesh LRetractable needle/syringe devices for blood collection, catheterization, and medicinal injection procedures
US5102393A (en)*1989-07-171992-04-07Survival Technology, Inc.Autoinjector converted from intramuscular to subcutaneous mode of injection
US5709668A (en)*1991-01-161998-01-20Senetek PlcAutomatic medicament injector employing non-coring needle
EP0598055A4 (en)*1991-08-061995-05-24Senetek Plc MEDICAMENT INJECTOR AND METHOD.
US5562635A (en)*1992-04-211996-10-08Eastland Technology Australia Pty LtdParenteral device
EP0616541A4 (en)*1992-10-051995-04-19Senetek Plc DRUG INJECTORS AND METHODS.
US5762633A (en)*1993-10-261998-06-09Eastland Technology Australia Pty, Ltd.Syringe or like parenteral device
WO1995011712A1 (en)*1993-10-261995-05-04Eastland Technology Australia Pty. Ltd.Syringe or like parenteral device
WO1997002855A1 (en)*1995-07-121997-01-30Societe D'etudes Et D'applications Techniques - SedatSelf-protected injection syringe
US6110147A (en)*1995-07-122000-08-29Societe D'etudes D'applications Techniques-SedatSelf-protected injection syringe
US6569124B1 (en)1995-07-122003-05-27Societe D'etudes Et D'applications Techniques-SedatSelf-protected injection syringe
US5993418A (en)*1998-02-241999-11-30Medisys Technologies, Inc.Safety syringe
US6450216B1 (en)*1998-10-262002-09-17Valois, S.A.Reservoir provided with a device for closing and/or filling and device for dispensing a fluid product comprising same
US6626863B1 (en)2000-11-222003-09-30Nusaf, L.L.C.Safety syringe
US20050029288A1 (en)*2001-11-152005-02-10Frederic HeldtFluid product dispensing device
US8419706B2 (en)*2001-11-152013-04-16Aptar France SasFluid product dispensing device
JP2012519512A (en)*2009-03-062012-08-30サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Seal member for a syringe with a retractable needle
WO2010100244A1 (en)*2009-03-062010-09-10Sanofi-Aventis Deutschland GmbhSeal member for syringe with retractable needle
US8597256B2 (en)2009-03-062013-12-03Sanofi-Aventis Deutschland GmbhSeal member
JP2013542022A (en)*2010-11-032013-11-21サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Medicinal module with a deformable membrane
AU2020200659B2 (en)*2011-10-142021-10-21Amgen Inc.Injector and method of assembly
US11160931B2 (en)2011-10-142021-11-02Amgen Inc.Method of assembling and filling a drug delivery device
US20160199578A1 (en)*2011-10-142016-07-14Amgen Inc.Injector and method of assembly
US20180256821A1 (en)*2011-10-142018-09-13Amgen Inc.Injector and method of assembly
US12329943B2 (en)2011-10-142025-06-17Amgen Inc.Injector and method of assembly
US11298463B2 (en)2011-10-142022-04-12Amgen Inc.Method of assembling and filling a drug delivery device
US11273260B2 (en)2011-10-142022-03-15Amgen Inc.Injector and method of assembly
US10314976B2 (en)2011-10-142019-06-11Amgen Inc.Method of assembling and filling a drug delivery device
US20160166765A1 (en)*2011-10-142016-06-16Amgen Inc.Injector and method of assembly
US10537681B2 (en)*2011-10-142020-01-21Amgen Inc.Injector and method of assembly
US10537682B2 (en)*2011-10-142020-01-21Amgen Inc.Injector and method of assembly
US20200179609A1 (en)*2011-10-142020-06-11Amgen Inc.Injector and method of assembly
US11129941B2 (en)2011-10-142021-09-28Amgen Inc.Method of assembling and filling a drug delivery device
US11110225B2 (en)*2011-10-142021-09-07Amgen Inc.Injector and method of assembly
US11058821B2 (en)*2011-10-142021-07-13Amgen Inc.Injector and method of assembly
US20150335827A1 (en)*2012-12-192015-11-26Novo Nordisk A/SA Needle Device
US10850037B2 (en)2013-03-222020-12-01Amgen Inc.Injector and method of assembly
US11759571B2 (en)2013-03-222023-09-19Amgen Inc.Injector and method of assembly
US11097055B2 (en)2013-10-242021-08-24Amgen Inc.Injector and method of assembly
US12427260B2 (en)2013-10-242025-09-30Amgen Inc.Injector and method of assembly
JP2020532379A (en)*2017-08-302020-11-12ピルエット メディカル エルエルシー Compact automatic syringe
US10449296B2 (en)*2017-08-302019-10-22Pirouette Medical LLCCompact auto-injector
US20190167905A1 (en)*2017-08-302019-06-06Pirouette Medical LLCCompact auto-injector
US10265471B2 (en)*2017-08-302019-04-23Pirouette Medical LLCCompact auto-injector
US12011569B2 (en)2017-08-302024-06-18Pirouette Medical Inc.Compact auto-injector
US20190060569A1 (en)*2017-08-302019-02-28Pirouette Medical LLCCompact auto-injector
US20220379044A1 (en)*2019-09-202022-12-01Meiragtx Therapeutics, Inc.Injection Systems and Methods of Their Use

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