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US3358865A - Container closure - Google Patents

Container closure
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Publication number
US3358865A
US3358865AUS489184AUS48918465AUS3358865AUS 3358865 AUS3358865 AUS 3358865AUS 489184 AUS489184 AUS 489184AUS 48918465 AUS48918465 AUS 48918465AUS 3358865 AUS3358865 AUS 3358865A
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Prior art keywords
cap
stopper
button
bottle
annular
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US489184A
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Andersen Eli Frank
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West Pharmaceutical Services Inc
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West Co Inc
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Priority to US489184ApriorityCriticalpatent/US3358865A/en
Priority to US650146Aprioritypatent/US3379326A/en
Priority to US650145Aprioritypatent/US3446170A/en
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Publication of US3358865ApublicationCriticalpatent/US3358865A/en
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Dec. 19, 1967 E. F. ANDERSEN CONTAINER CLOSURE 2 Sheets-Sheet 1 Filed Sept. 22, 1965 INVENTORZ ELI FRANK ANDERSEN ATTYS.
1967 I E. F. ANDERSEN 3,358,865
CONTAINER CLOSURE Filed Sept. 22, 1965 2 Sheets-Sheet 2 mvewroai ELI FRANK ANDERSEN ATTYS Patented Dec. 19, 1967 Vania Filed Sept. 22, 1965, Ser. No. 489,184 4 Claims. (Cl. 21538) ABSCT OF THE DISCLOSURE A truly tamperproof container closure for closing the opening in a container and particularly adapted to hold a stopper in place in a pharmaceutical bottle or the like comprising a cup-like cap with an annular top portion and a skirt depending from the outer peripheral edge of the annular portion and a button projecting from the top connected to the annular portion by means of a plurality of fracturable bridge members and a cover member of disc-like form with a central opening. The button projects through the opening in the cover and has a flange holding the cover member in place. The cover member is actuatable relative to the cap thereby to break the fracturable bridge means and expose the stopper covering the opening in the container thereby to permit the contents of the container to be withdrawn.
This invention relates to improvements in tamperproof container closures and to a new improved simplified method for making the same.
Container closures of the type to which the present invention relates are particularly adapted for use on pharmaceutical containers or bottles. At present, closures for certain types of pharmaceutical bottles have a piercible closure member in the form of a disc or stopper made of rubber or like material and a metalic cap to hold the stopper in place. The metallic caps generally include an inner central removable disc portion detachably secured to an outer annular top portion of the cap by fracturable bridge means. In this type of closure, the user removes the central disc portion by inserting a fingernail beneath the disc to pry it upwardly thereby fracturing the bridge connections and exposing the stopper for piercing by a hypodermic syringe to withdraw the contents of the container. This type of closure in addition to being comparatively expensive to make, presents several disadvantages in use. For example, removal of the disc in the normal use requires both hands of the user, one to support the bottle and one to grip the disc adjacent the bridge connections. The proximity of the hand to the bridges presents the possibility of injury on the rough sharp edges of the fractured bridges created on removal of the disc. Additionally, in some instances during assembly of the caps on the bottles, the connecting bridges have been broken in tumbling about due to the instability of the disc and the tendency to tilt or be tilted out of the plane at the top whereby the edge of one cap is caught or twisted under an upturned edge of another resulting in premature breaking of the disc.
In another prior type of container closure, a cover member which overlies the top and disc of the cap is provided which has a depending central portion engaging under the edge of an opening in the disc member. Even though this type of container closure is efiective for the purpose intended, it has been found that special equipment is required to assemble the cover to the cap and that the overall method of assembling the elements of the container closure is somewhat excensive.
With the foregoing in mind, an object of the present invention is to provide a so-called tamperproof cap and cover for pharmaceutical containers or bottles which is extremely simplified in construction and which leads itself to a one-hand removal operation, and wherein there are no sharp or jagged edges which present a risk of injury to the user.
Another object of the present invention is to provide a new and improved simplified method of making a tamperproof closure in a highly economical manner.
One form of container closure in accordance with the present invention comprises an outer cap having an annular top portion with a central opening, a disc member disposed between the top portion of the cap and the stopper and a button secured by fracturable bridge means to the disc and projecting through the opening in the cap. This assembly is extremely economical to make. Moreover, in order to withdraw the contents of the container by means of a syringe, the user merely supports the bottle in one hand and tilts the button with the thumb of the hand whereby the button is severed from the disc at the fracturable bridge connections to expose the stopper through the opening in the top portion of the cap. By this construction, the top portion of the cap overlies the fractured bridges thereby minimizing the possibility of injury to the user. In accordance with another embodiment of the invention, the button is connected to the top portion of the cap by fracturable bridge means and a cover member with a central opening is supported by the button in overlying relation to the top of the cap. With this arrangement, the button is removable to expose the stopper simply by engaging the cover and prying it upwardly relative to the cap.
The foregoing and other objects of the present invention and the various details of the construction and arrangement thereof are hereinafter more fully set forth and described with reference to the accompanying drawings, in which:
FIG. 1 is a fragmentary side elevational view of a container closure in accordance with the present invention secured in position on a bottle;
FIG. 2 is an enlarged plan view of the closure With a portion of the cover member broken away to more clearly illustrate the construction;
FIG. 3 is an enlarged sectional view taken on lines 33 of FIG. 2;
FIG. 4 is a sectional view similar to FIG. 3 showing the removal of the central disc portion;
FIG. 5 is a schematic view illustrating apparatus for carrying out a method of making a tamperproof container closure in accordance with the present invention;
FIG. 6 is an enlarged sectional view taken on lines 6-6 of FIG. 5;
FIG. 7 is a side elevational view of a cap as formed by the cap forming machine; and
FIG. 8 is an enlarged fragmentary view taken along lines 8-8 of FIG. 5.
Referring now to the drawings, and particularly to the embodiment of the invention shown in FIGS. 1-4,reference numeral 10 designates generally a container assembly comprising a bottle of conventional form, a portion of which is shown in FIG. 1, and astopper 12 adapted to fit in the opening in the neck of the bottle. Thestopper 12, which may be made of rubber or like material, has aplug portion 14 adapted to fit within theneck 16 of the bottle, aperipheral flange 18 which seats against thelip 20 of the bottle and acentral wall portion 22 of thinner cross section so that it may be pierced by the needle of a hypodermic syringe to gain access to the contents of the bottle. While a particular configuration of stopper has been illustrated, the present invention is not concerned with the particular form employed and other types may be used in lieu of the one illustrated.
Acap 24 of generally cup-like form and preferably made of a sheet material such as aluminum serves to hold the stopper in place to seal the contents of the bottle. Thecap 24 has anannular top portion 26 defining a central opening ofcircular shape 28 and an outer peripheral skirt orside wall 30 depending from the outer periphery of theannular top portion 26. Theside wall 30 of the cap which prior to assembly to the bottle is straight is adapted to be crimped or spun inwardly at its lower terminal edge to provide a circumferentially extending, inwardly projectingrim portion 32 adapted to engage under ashoulder 34 on the bottle below the lip thereof, thereby to permanently secure the cap to the bottle.
In the present instance, the cap further includes a central projection in the form of a raisedbutton 40 having a generallycylindrical body portion 42 and a circumferentially extendingannular disc portion 44 projecting radially from the lower terminal edge of the cylindrical body portion which in turn is connected to the inner edge of theannular top portion 26 in the present instance by means of threeequispaced bridge connections 48. Acover member 50 having acentral opening 52 engages over the body portion of the button and is held thereto as illustrated in FIG. 4 between theflattened head 54 of the button and thedisc portion 44. Thiscover member 50 is preferably made of a plastic material and is disc-like in form having aninner face 50a conforming to the configuration of the top portion of the cap and an outer depending circumferentially extending edge orlip 56 which engages over the side wall of the cap and snugly embraces the cap in the manner shown in FIG. 3 so that the cap is snugly nested in the under surface of the cover. In this manner thecover member 50 serves as a seal to preclude infiltration of dirt and foreign matter in the area between the cap and stopper or between the stopper and lip of the bottle. Further the cover member overlies the bridge connections ormembers 48 thereby eliminating the tendency of the removable disc to be tilted or raised during production and transportation prior to assembly to the bottle.
Now with the closure assembled to the bottle as illustnated in FIG. 4, when the user desires to withdraw the contents of the bottle, the bottle is merely supported in the palm of the hand with the tip of the thumb engaging the peripheraldownturned lip 56 of thecover member 50. Now, by exerting an upward force on the cover, it is displaced upwardly, the portion thereof diametrically opposed from the area engaged by the thumb of the user serving as the fulcrum of a lever and supporting the cover as thebridges 48 are fractured. It is noted that the raising of the cover as illustrated in FIG. 4 severs the button at the bridge connections to expose the central portion of the stopper. As illustrated in FIG. 4 the fingers of the user are remote from any edges of the annular top portion of the cap. Further, the fingers of the user are remote from the exposed central portion of the stopper thereby minimizing the danger of contaminating the sterile stopper of the bottle.
There is illustrated in FIGS. -8, inclusive, a continuous system for making the container closure described above. In thissystem caps 71 of the form illustrated in FIG. 7 are made in a cap forming machine generally designated by thenumeral 70.
Thiscap forming machine 70 may simply comprise a conventional die stamping apparatus which forms the cap from sheet material such as aluminum. Thecaps 71 as best illustrated in FIG. 7 comprise a generally cylindrical circumferentially extending skirt 72, an annular top 74 and an elongated button 76 having a radially extending annular projection 78 which is connected to the annular top 74 by a series of fracturable bridges. These caps are automatically fed from the cap forming machine and are positioned on a series ofcap support members 80 which as illustrated are connected in end to end relation and are actuated in an endless path by means of a suitablechain type conveyor 82. Each cap support member as illustrated in FIG. 10 includes a body portion 84 conforming generally to the shape of the top and skirt of the top and a spring biased pin 86 which engages interiorly of the button 76. As thecaps 70 are advanced by the conveyor from the cap forming machine, they pass under a cover element feed mechanism generally designated by the numeral 90. This feed mechanism includes a pair of feed and take uprolls 92 and 94 for supplying a strip of plastic material through cooperating die and anvil elements 96 and 98 which stamp outdisc-like elements 100 from thestrip 101. The disc-like cover elements 100 are delivered by means of achute 102 to a hopper 104. The bottom of the hopper has two discharge openings 106 spaced on either side of the bottom thereof and areciprocating slide element 110 which is actuated back and forth in timed relation with the conveyor whereby disc-like cover elements 100 are positioned on top of the caps on the conveyor. Downstream of the cover element feed station, there is provided a reciprocating press which engages the button on the cap and compresses it to secure the cover element in place on the cap. Thereafter, a heated die element 121 engages the assembled cover and cap elements to from the cover element to the final desired shape as illustrated in the extreme lefthand position of FIG. 5. Thereafter, the completed closure elements are ready for application to a container such as a bottle in the manner described above.
While a particular embodiment of the present invention has been illustrated and described herein and while a particular method of making a container closure in accordance with the present invention has been illustrated, it is, of course, to be understood that changes and modifications may be made therein within the scope of the following claims.
I claim:
1. In a tamperproof container closure for pharmaceutical bottles or the like adapted to hold a stopper in place in the neck of the bottle, a cap of cup-like form having an annular top portion and a skirt depending from the outer peripheral edge of the annular portion, said annular portion terminating in a inner edge defining a opening in the cap, and a button projecting upwardly from the top of the cap and connected at one end to the annular top portion by fracturable bridge means, a cover member of disc-like form having a central opening overlying the annular portion and circumscribing the button, the end of the button opposite said one end having a flange holding the cover member in place, said bridge means being fracturable upon actuation of the cover member to expose the stopper to permit the contents of the container to be withdrawn.
2. In combination with a bottle and a stopper adapted to fit within the neck of the bottle, a tamperproof closure comprising a cap adapted to hold the stopper in place, said cap being of cup-like form and comrising an annular top portion and a skirt depending from the outer peripheral edge of the annular portion, said annular portion terminating in an inner edge defining an opening in the cap, and a button projecting upwardly from the top of the cap and connected at one end to the annular top portion by fracturable bridge means, a cover member of disc-like form having a central opening overlying the annular portion and circumscribing the button, the end of the button opposite said one end having a flange holding the cover member in place, said bridge means being fracturable upon actuation of the cover member to expose the stopper to permit the contents of the container to be withdrawn.
3. In a tamperproof container closure for pharmaceutical bottles or the like adapted to hold a stopper in place in the neck of the bottle, a cap of cup-like form having an annular top portion and a skirt depending from the outer peripheral edge of the annular portion, said annular portion terminating in an inner edge defining an opening in the cap, and a button projecting upwardly from the top of the cap and connected at one end to the annular top portion by a plurality of circumferentially spaced fracturable bridge members, a cover member of disc-like form having a central opening overlying the annular portion and circumscribing the button, the end of the button opposite said one end having a flange holding the cover member in place, said bridge members being fracturable upon actuation of the cover member to expose the stopper to permit the contents of the container to be withdrawn.
4. In combination with a bottle and a stopper adapted to fit Within the neck of the bottle, a tamperproof closure comprising a cap adapted to hold the stopper in place, said cap being of cup-like form and comprising an annular top portion and a skirt depending from the outer peripheral edge of the annular portion, said annular portion terminating in an inner edge defining an opening in the cap, and a button projecting upwardly from the top of the cap and connected at one end to the annular top portion by a plurality of circumferentially spaced fracturable bridge members, a cover member of disc-like form having a central opening overlying the annular portion and circumscribing the button, the end of the button opposite said one end having a flange holding the cover member in place, said bridge member being fracturable upon actuation of the cover member to expose the stopper to permit the contents of the container to be withdrawn.
References Cited UNITED STATES PATENTS 651,460 6/ 1900 Higgens 215-42 2,135,386 11/1938 Crabbe 215-38 2,395,149 2/1946 Shaw 215-38 2,891,689 6/1959 Gould 215-38 2,964,206 12/ 1960 Everett 215-9 3,071,274 1/1963 Ravn 215-37 FOREIGN PATENTS 63 8,518 4/1962 Italy.
DONALD F. NORTON, Primary Examiner. JOSEPH R. LECLAIR, Examiner.

Claims (1)

  1. 2. IN COMBINATION WITH A BOTTLE AND A STOPPER ADAPTED TO FIT WITHIN THE NECK OF THE BOTTLE, A TAMPERPROOF CLOSURE COMPRISING A CAP ADAPTED TO HOLD THE STOPPER IN PLACE, SAID CAP BEING OF CUP-LIKE FORM AND COMPRISING AN ANNULAR TOP PORTION AND SKIRT DEPENDING FROM THE OUTER PERIPHERAL EDGE OF THE ANNULAR PORTION, SAID ANNULAR PORTION TERMINATING IN AN INNER EDGE DEFINING AN OPENING IN THE CAP, AND A BUTTON PROJECTING UPWARDLY FROM THE TOP OF THE CAP AND CONNECTED AT ONE END TO THE ANNULAR TOP PORTION BY FRACTURABLE BRIDGE MEANS, A COVER MEMBER OF DISC-LIKE FORM HAVING A CENTRAL OPENING OVERLYING THE ANNULAR PORTION AND CIRCUMSCRIBING THE BUTTON, THE END OF THE BUTTON OPPOSITE SAID ONE END HAVING A FLANGE HOLDING THE COVERE MEMBER IN PLACE, SAID BRIDGE MEANS BEING FRACTURABLE UPON ACTUATION OF THE COVER MEMBER TO EXPOSE THE STOPPER TO PERMIT THE CONTENTS OF THE CONTAINER TO BE WITHDRAWN.
US489184A1965-09-221965-09-22Container closureExpired - LifetimeUS3358865A (en)

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US489184AUS3358865A (en)1965-09-221965-09-22Container closure
US650146AUS3379326A (en)1965-09-221967-04-12Container closure
US650145AUS3446170A (en)1965-09-221967-04-12Method and system for making a container closure

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US489184AUS3358865A (en)1965-09-221965-09-22Container closure

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US3358865Atrue US3358865A (en)1967-12-19

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Cited By (33)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US4227617A (en)*1979-08-301980-10-14Aluminum Company Of AmericaContainer closure
US4265364A (en)*1978-08-251981-05-05Zenyu Kinzoku Co., Ltd.Bottle cap
US4280317A (en)*1980-04-161981-07-28Sperry CorporationAdjustable coupling apparatus
US4364485A (en)*1981-05-151982-12-21Schering CorporationInjectable fluid container and method
FR2508007A1 (en)*1981-06-191982-12-24Sisman RTop cap for pharmaceutical container - has capsule and disc which protects the usually employed elastomer stopper
DE8703422U1 (en)*1987-03-061987-04-16Pharma-Metall GmbH, 5190 Stolberg Closure for a container, preferably for pharmaceutical containers
EP0242453A3 (en)*1986-04-231989-04-26Tiziano BojardiMetal cap with improved means for its partial or total removal, particularly for medicinal product containers
US5080245A (en)*1990-03-221992-01-14The West Company IncorporatedBidirectional scoring
US5114030A (en)*1990-08-301992-05-19The West Company, IncorporatedTip off container cap with removable stem
US5152413A (en)*1990-07-261992-10-06The West Company, IncorporatedBridge design for tamper evident closures
WO1994020383A1 (en)*1993-03-031994-09-15Sterling Winthrop Inc.Closure for medication container
FR2711619A1 (en)*1993-10-211995-05-05EmaObturating device for bottle
US5494170A (en)*1993-05-061996-02-27Becton Dickinson And CompanyCombination stopper-shield closure
US5540674A (en)*1993-09-281996-07-30Abbott LaboratoriesSolution container with dual use access port
US5632396A (en)*1993-05-061997-05-27Becton, Dickinson And CompanyCombination stopper-shield closure
US5823373A (en)*1995-10-181998-10-20Daikyo Seiko, Ltd.Plastic cap and a process for the production of the same
US6173852B1 (en)*1997-01-072001-01-16Nycomed Imaging A/SContainer with cap having connector and spike
US6241112B1 (en)*1997-12-092001-06-05Helvoet Pharma Belgium N.V.Stopper for sealing infusion bottles
USD485365S1 (en)2002-09-032004-01-13Medical Instill Technologies, Inc.Vial
US20040141886A1 (en)*2000-02-112004-07-22Daniel PySealed containers and methods of making and filling same
USD522663S1 (en)2002-09-032006-06-06Medical Instill Technologies, Inc.Vial
US7077176B2 (en)2003-04-282006-07-18Medical Instill Technologies, Inc.Container with valve assembly for filling and dispensing substances, and apparatus and method for filling
USD533670S1 (en)2002-09-032006-12-12Medical Instill Technologies, Inc.Vial
US7186241B2 (en)2001-10-032007-03-06Medical Instill Technologies, Inc.Syringe with needle penetrable and laser resealable stopper
US20070102393A1 (en)*2005-09-202007-05-10BiomerieuxSpecimen enclosure apparatus and containers and closure devices for the same
US7290573B2 (en)2001-10-162007-11-06Medical Instill Technologies, Inc.Dispenser with sealed chamber, one-way valve and needle penetrable and laser resealable stopper
USD561908S1 (en)2002-09-032008-02-12Medical Instill Technologies, Inc.Vial
US7798185B2 (en)2005-08-012010-09-21Medical Instill Technologies, Inc.Dispenser and method for storing and dispensing sterile food product
US7810529B2 (en)2000-02-112010-10-12Medical Instill Technologies, Inc.Device with needle penetrable and laser resealable portion
US9296498B2 (en)2002-06-192016-03-29Medinstill Development LlcMethods of filling a sealed device
EP4085892A1 (en)2021-05-062022-11-09KAISHA PACKAGING Private Ltd.Tamper evident plastic closure for vials for storing substances for medical or pharmaceutical applications and use thereof
USD1006621S1 (en)2021-06-112023-12-05KAISHA PACKAGING Private Ltd.Tamper evident plastic closure
US20240124201A1 (en)*2021-02-192024-04-18Braunform GmbhCap for closing a container for administering a medication, and method for producing same

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* Cited by examiner, † Cited by third party
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US651460A (en)*1895-08-271900-06-12Charles M HigginsBottle cap and stopper.
US2135386A (en)*1937-06-181938-11-01Phoenix Metal Cap Co IncClosure for containers
US2395149A (en)*1944-09-111946-02-19John E B ShawParenteral bottle construction
US2891689A (en)*1955-07-061959-06-23Gutmann & Co FerdClosures for packages of biological products
US2964206A (en)*1958-03-061960-12-13James C EverettCap
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Patent Citations (6)

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US651460A (en)*1895-08-271900-06-12Charles M HigginsBottle cap and stopper.
US2135386A (en)*1937-06-181938-11-01Phoenix Metal Cap Co IncClosure for containers
US2395149A (en)*1944-09-111946-02-19John E B ShawParenteral bottle construction
US2891689A (en)*1955-07-061959-06-23Gutmann & Co FerdClosures for packages of biological products
US2964206A (en)*1958-03-061960-12-13James C EverettCap
US3071274A (en)*1961-04-041963-01-01West CoCap structure for bottles

Cited By (58)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US4265364A (en)*1978-08-251981-05-05Zenyu Kinzoku Co., Ltd.Bottle cap
US4227617A (en)*1979-08-301980-10-14Aluminum Company Of AmericaContainer closure
DE3028281A1 (en)*1979-08-301982-02-18Aluminum Company Of America, Pittsburgh, Pa. LOCKING ARRANGEMENT
US4280317A (en)*1980-04-161981-07-28Sperry CorporationAdjustable coupling apparatus
US4364485A (en)*1981-05-151982-12-21Schering CorporationInjectable fluid container and method
FR2508007A1 (en)*1981-06-191982-12-24Sisman RTop cap for pharmaceutical container - has capsule and disc which protects the usually employed elastomer stopper
EP0242453A3 (en)*1986-04-231989-04-26Tiziano BojardiMetal cap with improved means for its partial or total removal, particularly for medicinal product containers
DE8703422U1 (en)*1987-03-061987-04-16Pharma-Metall GmbH, 5190 Stolberg Closure for a container, preferably for pharmaceutical containers
US5080245A (en)*1990-03-221992-01-14The West Company IncorporatedBidirectional scoring
US5152413A (en)*1990-07-261992-10-06The West Company, IncorporatedBridge design for tamper evident closures
US5114030A (en)*1990-08-301992-05-19The West Company, IncorporatedTip off container cap with removable stem
WO1994020383A1 (en)*1993-03-031994-09-15Sterling Winthrop Inc.Closure for medication container
US5464111A (en)*1993-03-031995-11-07Sterling WinthropClosure for medication container
US5494170A (en)*1993-05-061996-02-27Becton Dickinson And CompanyCombination stopper-shield closure
US5632396A (en)*1993-05-061997-05-27Becton, Dickinson And CompanyCombination stopper-shield closure
US5540674A (en)*1993-09-281996-07-30Abbott LaboratoriesSolution container with dual use access port
FR2711619A1 (en)*1993-10-211995-05-05EmaObturating device for bottle
US5779074A (en)*1994-07-261998-07-14Becton, Dickinson And CompanyCombination stopper-shield closure
US5823373A (en)*1995-10-181998-10-20Daikyo Seiko, Ltd.Plastic cap and a process for the production of the same
US6042770A (en)*1995-10-182000-03-28Daikyo Seiko Ltd.Process for the production of plastic cap
US6173852B1 (en)*1997-01-072001-01-16Nycomed Imaging A/SContainer with cap having connector and spike
US6241112B1 (en)*1997-12-092001-06-05Helvoet Pharma Belgium N.V.Stopper for sealing infusion bottles
US7992597B2 (en)2000-02-112011-08-09Medical Instill Technologies, Inc.Sealed containers and methods of filling and resealing same
US8960242B2 (en)2000-02-112015-02-24Medinstill Development LlcSealed containers and methods of filling and resealing same
US20170334585A1 (en)*2000-02-112017-11-23Medinstill Development LlcSealed containers and methods of filling and resealing same
US9637251B2 (en)2000-02-112017-05-02Medinstill Development LlcSealed containers and methods of filling and resealing same
US9549874B2 (en)2000-02-112017-01-24Medinstill Development LlcDevice with penetrable and resealable portion and related method
US7100646B2 (en)2000-02-112006-09-05Medical Instill Technologies, Inc.Sealed containers and methods of making and filling same
US9051064B2 (en)2000-02-112015-06-09Medinstill Development LlcResealable containers and methods of making, filling and resealing same
US20040141886A1 (en)*2000-02-112004-07-22Daniel PySealed containers and methods of making and filling same
US8631838B2 (en)2000-02-112014-01-21Medical Instill Technologies, Inc.Device with penetrable and resealable portion and related method
US8347923B2 (en)2000-02-112013-01-08Medical Instill Technologies, Inc.Device with penetrable and resealable portion and related method
US7980276B2 (en)2000-02-112011-07-19Medical Instill Technologies, Inc.Device with needle penetrable and laser resealable portion and related method
US7967034B2 (en)2000-02-112011-06-28Medical Instill Technologies, Inc.Device with needle penetrable and laser resealable portion and related method
US7810529B2 (en)2000-02-112010-10-12Medical Instill Technologies, Inc.Device with needle penetrable and laser resealable portion
US7726352B2 (en)2000-02-112010-06-01Medical Instill Technologies, Inc.Sealed containers and methods of making and filling same
US7726357B2 (en)2000-02-112010-06-01Medical Instill Technologies, Inc.Resealable containers and assemblies for filling and resealing same
US7186241B2 (en)2001-10-032007-03-06Medical Instill Technologies, Inc.Syringe with needle penetrable and laser resealable stopper
US7779609B2 (en)2001-10-032010-08-24Medical Instill Technologies, Inc.Method of filling a device
US8220507B2 (en)2001-10-162012-07-17Medical Instill Technologies, Inc.Dispenser and method for storing and dispensing sterile product
US9630755B2 (en)2001-10-162017-04-25Medinstill Development LlcDispenser and method for storing and dispensing sterile product
US7290573B2 (en)2001-10-162007-11-06Medical Instill Technologies, Inc.Dispenser with sealed chamber, one-way valve and needle penetrable and laser resealable stopper
US9296498B2 (en)2002-06-192016-03-29Medinstill Development LlcMethods of filling a sealed device
USD485365S1 (en)2002-09-032004-01-13Medical Instill Technologies, Inc.Vial
USD598124S1 (en)2002-09-032009-08-11Medical Instill Technologies, Inc.Vial
USD561908S1 (en)2002-09-032008-02-12Medical Instill Technologies, Inc.Vial
USD505494S1 (en)2002-09-032005-05-24Medical Instill Technologies, Inc.Vial
USD522663S1 (en)2002-09-032006-06-06Medical Instill Technologies, Inc.Vial
USD533670S1 (en)2002-09-032006-12-12Medical Instill Technologies, Inc.Vial
US7568509B2 (en)2003-04-282009-08-04Medical Instill Technologies, Inc.Container with valve assembly, and apparatus and method for filling
US7077176B2 (en)2003-04-282006-07-18Medical Instill Technologies, Inc.Container with valve assembly for filling and dispensing substances, and apparatus and method for filling
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