US2953132A - Parenteral solution equipment - Google Patents

Description

Sept. 20, 1960 J. W. RICHTER ETAL PARENTERAL SOLUTION EQUIPMENT Filed Oct. 27, 1955 John M Richter Theodore H Geucakt Cyrus E. Bram-M.

IN V EN TORS BY Mom: flr-rorney PARENTERAL SOLUTION EQUIPMENT John W. Richter, Niles, Theodore H. Gewecke, Glenview, and Cyrus R. Broman, Evanston, 111., assignors to Baxter Laboratories, Inc., Morton Grove, Ill.

Filed Oct. 27, 1955, Ser. No. 543,129

2 Claims. Cl. 128-272) This invention relates -to parenteral solution equipment and the method of using same and, more particularly, to container equipment adapted to unite parenteral medicaments just prior to administration thereof.

Inasmuch as parenteral solutions are commonly used in surgical procedures, they have been found to provide convenient vehicles for supplemental medication. Where, for example, the surgeon desires to administer a parenteral anesthetic, skeletal muscle relaxant, antibiotic, or the like, and a parenteral solution regimen such as saline is also contemplated, it is distinctively advantageous to combine the two. This eliminates the need for making an additional vein puncture which is oftentimes painful and inconvenient.

To achieve the foregoing, we have invented parenteral solution equipment including a container for the supplemental medication which is adapted to introduce the medicine into an already provided parenteral solution bottle, the introduction being performed under substantially aseptic conditions and without loss of the medicine which is usually expensive and carefully controlled in quantity.

The invention set forth in this application constitutes an improvement in the structure disclosed in John W. Richters application Serial No. 536,140. Essentially, the additive vial structure described in that application includes a container closed by a flexible diaphragm whereby flexing of the diaphragm causes a pumping action which permits transfer of liquid into and out of the container. A

Inasmuch as the parenteral solution bottle into which the contents of the additive vial are introduced is generally provided with an internal pressure less than atmospheric, a problem is presented in that the sub-atmospheric pressure bottle tends to exert an unusually strong pull upon the flexible diaphragm of the supplemental medication device when the two are interconnected. Then, when it is attempted to pull the supplemental medication device away from the parenteral solution bottle to achieve the desired pumping action by reversely flexing the diaphragm, a strong pull must be exerted that might well result in disconnecting the device from the bottle and bring about a loss of the devices contents. The present invention is designed to meet the foregoing problem and overcome the described difliculties.

Our invention will be explained in conjunction with the accompanying drawing in which Fig. 1 is a perspective view of the container of our invention in combination with a parenteral solution bottle; Fig. 2 is an enlarged cross-sectional view of the container of Fig. 1; and Fig. 3 is a view similar to Fig. 2 but showing the container in operative condition.

Referring now to the drawing and, in particular, to Fig. 1, the numeral designates generally a container for a supplemental medicament which also might be termed as additive vial.Vial 10 includes a glass container 11 having a mouth at one end. Closing the mouth nited States Patent Patented Sept. 20, 1960 Bottle 14 is provided with. rubber stopper 16 mounted in its neck and provided with an annular flange 16a overlying the upper lip of bottle 14. Securing stopper 16 in the neck portion of the bottle 14 isclamping ring 17 which is rolled on in a conventional fashion. An annular bead (not shown) of bottle 14 provides the anchoring means forclamping ring 17. Overlying stopper 16 isfrangible rubber disc 18.

Extending through stopper 16 is a solution outlet passage (not shown but indicated by vacuum dimple 19 in disc 1%). Vacuum dimple 19 is evidence that a sub-atmospheric pressure exists within bottle 14.

Also extending through stopper 16 is a second passage constituting an air inlet to bottle 14 during administration ofsolution 15. Mounted in this second passage and extending inwardly of bottle 14 isair tube 20. Whensolution 15 is to be administered, bottle 14 is mounted in mouth-downward fashion by means of a suspension device consisting of bail 21 andband 22 so that air tube 21' permits air to enter bottle 14 to replacesolution 15 discharged through the outlet passage of stopper 16.

When it is desired to supplementsolution 15 with a medicament of the character hereinbefore described or with one that is relatively unstable when provided in a solution form, it is merely necessary to insert thedispensing closure pontion 12 ofmedicament containing vial 10 into the outlet passage of stopper 16.

In Fig. 2, dispensingclosure 12 is seen to include a cap-like plug generally designated 23 which covers the mouth of container 11. In the embodiment shown, the body ofplug 23 is provided with anarched diaphragm portion 24 and a dependingannular skirt 25 which permits convenient positioning ofplug 23 in the mouth of container 11.Plug 23 is also provided with an annular upstanding shoulder-26 which, in combination with theannular bead 27 of container 11, permits securement ofplug 23 to container 11 byclamping ring 13. This securement is readily achieved by providingring 13 in the form of a metal collar and rolling the lower edge as at 13a to griphead 27.

Diaphragm portion 24 is provided with a centrally positionedaperture 28 which permits outflow ofsupplemental medicament 29. In the embodiment shown in Fig. 2, aperture orpassage 28 is closed by hingedvalve 28a which is provided integral withdiaphragm portion 24.

Integral withdiaphragm portion 24 and extending outwardly therefrom is a neck-like portion 30.Necklike portion 30 is positioned aboutaperture 28 and is adapted to receive dispensingspout 31 and hold the same in a substantially airtight grip achieved by integralmale threads 31a. Prior to use of the thus assembledcontainer 10, we provide a protector cap as indicated at 32 to close off the puncturing end ofspout 31. We also provideannular flange 31b onspout 31 to serve as a gripping means for insertion and removal ofspout 31 from the outlet passage of a parenteral solution bottle stopper.

The use of thecontainer 10 can be appreciated with a consideration of Fig. 1 wherein thespout 31 ofcontainer 10 is shown positioned above the dispensing closure portion of a parenteral solution bottle prior to insertion therein.Spout 31 can be adapted to puncture any frangible closure means overlying stopper 16 such asdisc 18 in the event such closure means is not removed prior to use. Afterspout 31 is inserted into stopper 16, thereby communicating the interior ofcontainer 10 with that of bottle 14,medicament 29 can be forced downwardly throughaperture 28 and the bore ofspout 31 merely by pumpingcontainer 10. The pumping action referred to involves a relative longitudinal movementof container with respect to the larger-'parenteral solution bottle so as to causeresilient diaphragm portion 24 to flex, thereby varying the internal volume ofcontainer 10. e

i is lowermost.

We have discovered that the effect of the vacuum in container 14 aftervial 10 has been attached can be overcome by filleting or thickening that portion ofplug 23 at the juncture betweendiaphragm portion 24 andannular skirt 25 as at 24a. Thus,- there is provided a heavy and relatively non-flexing annular portion that rests against the side and upon the top of .the rim ofcontainer 10 which causesplug 23 to'assume its static position shown in Fig. 2' whenever it has been flexed as shown in Fig. 3. V v V The arched, or steeply pitcheddiaphragm portion 24, as indicated specifically at 24b also urges a return to the structure of Fig. 2 after thediaphragm portion 24 has been doubled back substantially upon itself, as illustrated in Fig. 3. This return, therefore, is achieved irrespective of the influence of vacuum generally existing within bottle 14.

In contrast to the desirable result obtained by the structural features ofplug 23 described above, the provision of a plug with a flat diaphragm portion would result in ;a tendency of the diaphragm to remain in the doubled backfposition of Fig. 3 under the influence of the vacuum in bottle 14. In addition, thearched diaphragm portion 24, the wall portions of which are extended upwardly in almost a vertical plane, permits the achievement of another new result-the substantial variation of the internal volume ofvial 10 without having to flex diaphragm portion outwardly.

ofvial 10 from bottle 14 during pumping. In the embodiment shown, it is only necessary to pushvial 10 downwardly toward bottle 14 to achieve pumping, the vial returning to its normal or static position without the 7 need for exerting a pulling force.

7 Operation Oncespout 31 has been inserted into the outlet pas- Thus, we have fur-. ther minimized the possibility of accidental disengagement sage indicated by dimple 19 as outlined above, it is 7 only necessary to thrust down lightly onvial 10 to causemedicament 29 to be forced, out ofvial 10 into bottle 14.

V The same downward movement causesneck-like portion 'vial 10 is essentially a closed container untilcommunh cation between it and bottle 14 is established;

The above procedureis followed whenmedicament 29 is a liquid, and in the event all medicament is not forced into bottle. 14 by one'thrust, subsequent relative move-.

ment of vial '10 with respect to bottle 14 causes the remaining medicament to flow throughspout 30 into bottle 14. We prefer to refer to this as a pumping action since the inward flexing ofdiaphragm 24 results in a smaller 4 7 internal volume invial 10 .with'an attendant increase in pressure. 7

In an analogous fashion,medicament 29, if a solid, can be transferred. Such may be the case where it is impossible to provide certain drugs in a stable liquid form. Whenmedicament 29 is a solid, it can be transferred by inverting the united containers so that the additivevial Thrusting vial 10 upwardly causesvalve 28a to open andsolution 29- from bottle 14 to run intovial 10. Upon reinversion. of the united containers, solution-bornesolid medicament 29 can be pumped ou ofvial 10 as set forth above with respect: to the operation involving a medicament originally. provided in liquid form.

The foregoing detailed description has been given for clearness of understanding only and no unnecessary limitations are to be inferred therefrom.

We claim; i V

1. In adevice for adding asupplemental medicine to a parenteral solution container, a vial having an open mouth providing a closurc-supportinglip andhaving an external bead about said-mouth, a resilient closure over said mouthhaving an edge portion supported on said lip and having an outwardly arched flexible central portion, said closure also having an inwardly depending annular skirt receivedwithin the open mouth of said ivial, a juncture between said 7 central portionandsaid skirt being filleted to providea relatively thick non-flexing skirt and a relatively thin central portionwhereby the central portion is induced to return to its nit-flexed condition after being flexed, an aperture in said central portion and an outwardly extending integral tubular projection about said aperture, a rigid puncturing spout in said projection, and a circular metal clamping ring engaging said bead and said edge portion to seal said closure to said vial, said outwardly arched central portion being generally dome-shaped inwardly and outwardly thereof and providing an annular portion between said, tubular projection and said closure edge portion, said annular portion being deformable upon movement of said spout inwardly of said vial, said annular portion, when so deformed, being generally folded on itself and thereby being elfective to urge said spout outwardly of said vialt 2; The structure of claim 1 in which said edge portion is equipped with an upwardly extending generally rounded annular shoulder that, with saidoutwardly arched central portion, provides acircular recess in which one edge of said clamping ring is received.

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