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US2819718A - Drainage tube - Google Patents

Drainage tube
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US2819718A
US2819718AUS368375AUS36837553AUS2819718AUS 2819718 AUS2819718 AUS 2819718AUS 368375 AUS368375 AUS 368375AUS 36837553 AUS36837553 AUS 36837553AUS 2819718 AUS2819718 AUS 2819718A
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tube
drainage
catheter
duct
membrane
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US368375A
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Isidore H Goldman
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Jan. 14, 1958 Filed July 16, 1955 l. H. GOLDMAN 2,819,718
DRAINAE' TUBE Z'SheetS-Sheet 1 INVENTOR- 1.5100125 -H. GaLDMAN Jan. 14, 1958 l. H. GOLDMAN DRAINAGE TUBE 2 Shegts-Sheet 2 Filed July 16, 1953 INVENTOR. (8/0025 H. GOLD/YUM 9 Q v i X United States Patent DRAINAGETUBE Isidore H. Goldman, New York; N. Y.. Application July 16, 1953, Serial No. 368,375 a Claims. (Cl.128-'-350)f This invention relates to catheters; This invention has as its mainobject the'alleviation of pain and discomfort caused by' the conventional-type of catheter wherein the retention means wheninflated causes' a compression of the tube thereatresulting in painand discomfort by inability to void at a rate sufficient to relieve the pressure of the waste products.
Catheters currently in use-consistessentially of a flexible elongated tube terminating in a closed poi'nted end adapted'to be inserted into the urinaryorotherbladderor opening of the body and are'provided" nearsaid pointed end' with openings for drainage. Thesecatheters are-further provided with inflatable members adjacent said drainage openings whereby to retain the closedendof the catheter within the bladder and also with independent drainage and inflation ducts'extending to the outer open endofthe device. However, sincethe walls'ofl'the drainage duct also form the inner walls for the inflatableportion, the air or other compressedfluid within theinilatabIe portion tends to collapse the walls of the drainage'du'ct inwardly, seriously impairing the effectiveness of the device.
It is accordingly a principal-object of the present invention to provide an improved catheter of'the type having inflatable retention means wherein collapse of the walls of the drainage-duct is prevented when the retention means are inflated.
It is another object of present invention to provide an drawing. It is to be noted that the drawing is intended to serve the purpose of illustration only, and that it is neither desired nor intended to limit the invention necessary to any or all of the exact details of construction shown except insofar as they may be deemed essential to the invention.
Referring briefly to the drawing,
Figure l is a perspective view of a catheter embodying the features of the present invention and with the retention means shown deflated;
Fig. 2 is a longitudinal sectional view taken along the line 2-2 of Fig. 1;
Fig. 3 is a transverse sectional view taken along the line 3-3 of Fig. 2;
Fig. 4 is a perspective view showing the retention means inflated and the device operative for use;
Fig. 5 is a view similar to Fig. 2 but showing the retention means inflated Within the bladder walls;
"ice
Fig. 6 is aperspective-view ofthe-insert preventing eollapse of the drainage duct, shown alone;
Fig. 7 isaview similar to Fig. 5 of a conventional catheter showing the collapse of thedrainage duct'walls upon inflation of the retention means; and
Fig. 8 is a fragmentary view similar to Fig. 2' but showing' a modified form of-the'invention.
Referring now in detail to the drawing, ltl-represents an elongated flexible tubeof rubber or other suitable material having a closed;pointed end 11 to facilitate insertion intothe urethra or other bodyopening, the outer open end of the tube: ltl being flared'outwardly...as at 12- and terminating in a relatively large cylindrical portion13.
The outer open end of the cylindrical vportion vided with a suitablestopper.14 (Eig.44.).
Thetube 10* adjacent the-pointed end11 is provi edwithsuitable drainage openings 15..
The interior of'the tube 101at=one side is reinforced-1a at 16, this reinforced portion extending from near theopenings 15 to near theflared portioni1-2 andi being provided with an inflationductli" over substantially: the length thereof.
Thetube 10 adjacent the outwardly flaredportion'. 12 is integrally formed with a substantially L-shaped tube 18having an outwardly flared outeropen end 19 andcomrnunicating with the inflation duct-17;
Thetube 10 near thedrainageopenings 15 is providd with anannular slit 20p1'ovidin g an annular outer membrane 21 (Fig. 2). The upper end-ofthedrainage duct 17 communicates with the annular slit 2tlby. meanszofca cut out or opening 22 (Figs. 2 and 3).
Ahollow insert 23 of substantially crescent-shaped cross section to facilitate fluid'flowf in the inflationmeans is positioned within the tube lowithin the portion thereof having theannular slit 20, the concave-portion 24iofsthe insert snugly receiving therewithin the correspondingly shaped reinforcedportion 16 having the inflation duct-'17 It will be noted that the construction permitsthemembrane 21, when collapsed, to present a smooth exterior to the tube 10' and to thereby facilitate the insertionand removal of the same between thewalls 25-- of the bladder.
Reinforcing tubes, I10USh0Wl1; may beprovidedwithin theinflation duct 17 during use.
To inflate themembrane 21 to the positions of Figs. 4 and 5, a hand pump, not shown, or other suitable inflating means may be connected to the flaredportion 19 of the tube 18. After inflation of themembrane 21, the tube 18 is doubled up, as shown in Fig. 4, and closed off with a rubber band 26, or other suitable means.
Thus, the catheter will be retained in the proper position within thebladder walls 25 by means of the inflatedmembrane 21 after the catheter has been inserted to the proper position.
Theinsert 23 prevents the inward movement of the walls surrounding thedrainage duct 27 when themembrane 21 is inflated. Were it not for theinsert 23, the walls of thedrainage duct 27 would be forced inwardly, as shown in Fig. 7, and preventing the proper drainage of the body liquid passing into the tube through thedrainage openings 15.
Theinsert 23 may be fabricated of any suitable material which will not be affected by the drainage liquid, its only requirement being that it have sutficient rigidity to prevent the collapsing of thedrainage duct 27 within themembrane portion 21. Thismember 23 may be molded or aflixed integrally with the catheter during production or this portion of the catheter may be treated for greater hardness and rigidityduring vulcanization.
By providing theinsert 23, it will be apparent that greater pressure may be exerted within themembrane 21, without closing thedrainage duct 27, permitting a 13 isprogreater expansion of the membrane and greater control of the internal pressure upon thewalls 25. This is particularly important when it is desired to control bleeding from blood vessels Within thewalls 25 in post-operative cases.
Also, while in the drawing the invention has been shown in connection with a catheter having oneinflation duct 17, it will be readily apparent that several inflation ducts may be provided on opposite sides of the tube, and that the present invention is equally applicable in such cases. Also, while there has been shown anannular membrane 21, it will be apparent that the invention is equally applicable to cases where a plurality ofindependent membranes 21 are provided for retaining the catheter within the bladder or wound.
Referring now particularly to Fig. 8, there is shown a modified form of the invention wherein the insert 23a of substantially crescent-shaped cross section is now formed from a continuous strip of spring wire.
In other respects the form of the invention shown in Fig. 8 is the same as that shown in Figs. 1 through 7, and like reference numerals identify like parts throughout the several views.
While various changes may be made in the detail construction, it shall be understood that such changes shall be within the spirit and scope of the present invention as defined by the appended claims.
I claim:
1. A catheter comprising an elongated flexible tube having a closed inner end provided with drainage openings, inflatable membrane means Provided in said tube near said drainage openings, inflation duct means communicating with said inflatable membrane means, and a rigid hollow section forming part of said tube and formed of the same material adjacent said membrane means whereby to prevent collapse of the main drainage opening within said tube upon inflation of said membrane means.
2. In combination, a catheter tube having an external and inflatable retention wall portion adjacent the opening of said tube, a removable insert within the tube and opposite the retention wall portion, said insert comprising a hollow member open at both ends and being relatively rigid.
3. A catheter comprising an elongated flexible tube having a central drainage duct, said tube being closed at 4 one end provided with drainage openings communicating 4 with said, drainage duct, the interior of said tube atleast one side being integrally formed with a reinforced portion, said reinforced portion having an inflation duct extending substantially the length thereof, said tube surrounding the end of said inflation duct near said drainage openings being provided with at least one slit providing at least one outer membrane, said inflation duct communicating with said slit, and a hollow insert open at both ends adapted to fit snugly within said drainage opening within the portion of said tube having said slit whereby to prevent closing of said drainage duct upon inflation of said membrane.
4. A catheter according toclaim 3, said tube at the end remote from said closed end having an enlarged substantially cylindrical portion open at its outer end, said tube further having an auxiliary tube integrally formed therein and communicating with said inflation duct, said auxiliary tube having an enlarged open outer end.
5. A catheter according toclaim 3, said insert having a concave portion adapted to receive therewithin said reinforced portion.
6. A catheter according to claim 5, said insert being formed from a unitary piece of non-corrosive material.
7. A catheter according to claim 5, said insert being formed from a continuous strip of spring wire.
8. In the combination of claim 2, said hollow member being substantially crescent-shaped in .cross section and 'formed from a unitary piece of non-corrosive material.
9. In the combination of claim 2, said hollow member being substantially crescent-shaped in cross section and formed from a continuous strip of spring wire.
10. A catheter comprising a hollow tube having inflatable retention means near one end thereof, a hollow insert open at both ends and frictionally fixed within and adjacent the end of said tube and Within said retention means whereby to prevent obstruction of the central bore of said tube when said retention means are inflated.
References Cited in the file of this patent
US368375A1953-07-161953-07-16Drainage tubeExpired - LifetimeUS2819718A (en)

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Cited By (60)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US3112748A (en)*1960-04-041963-12-03Pharmaseal LabSurgical tube
US3331371A (en)*1965-03-091967-07-18Prosit Service CorpCatheter having internal flow valve at distal end thereof
US3769980A (en)*1971-06-281973-11-06Medical Concepts IncMedical instruments
US3771527A (en)*1971-08-161973-11-13J RuisiSurgical drainage tube
US3773034A (en)*1971-11-241973-11-20Itt Research InstituteSteerable catheter
US4013077A (en)*1974-09-231977-03-22M.E.D.S. CorporationCollecting device
US4311140A (en)*1976-05-101982-01-19Henry BridgmanVacuum curet having an improved curetting opening
US4692141A (en)*1982-03-081987-09-08Mahurkar Sakharam DDouble lumen catheter
US4734094A (en)*1986-06-091988-03-29Jacob Erwin TCatheter and method for cholangiography
US4770652A (en)*1985-02-121988-09-13Mahurkar Sakharam DMethod and apparatus for using dual-lumen catheters for extracorporeal treatment
US4808155A (en)*1986-02-271989-02-28Mahurkar Sakharam DSimple double lumen catheter
US4850982A (en)*1987-03-091989-07-25Erlich Brian HCatheter
US4861337A (en)*1988-03-021989-08-29Sherwood Medical CompanyCollapsible urethral catheter
US4863424A (en)*1983-11-181989-09-05Blake Joseph W IiiTubular medical device and method of making and using the same
US4932959A (en)*1988-12-011990-06-12Advanced Cardiovascular Systems, Inc.Vascular catheter with releasably secured guidewire
US5195989A (en)*1990-09-171993-03-23Scimed Life Systems, Inc.Low profile catheter for increasing lumen size of a blood vessel and guide wire therefor
US5197951A (en)*1983-12-141993-03-30Mahurkar Sakharam DSimple double lumen catheter
US5221255A (en)*1990-01-101993-06-22Mahurkar Sakharam DReinforced multiple lumen catheter
US5318532A (en)*1989-10-031994-06-07C. R. Bard, Inc.Multilumen catheter with variable cross-section lumens
US5348536A (en)*1993-08-021994-09-20Quinton Instrument CompanyCoextruded catheter and method of forming
US5360403A (en)*1990-05-161994-11-01Lake Region Manufacturing Co., Inc.Balloon catheter with lumen occluder
US5374245A (en)*1990-01-101994-12-20Mahurkar; Sakharam D.Reinforced multiple-lumen catheter and apparatus and method for making the same
US5403291A (en)*1993-08-021995-04-04Quinton Instrument CompanyCatheter with elongated side holes
US5556390A (en)*1995-03-071996-09-17Quinton Instrument CompanyCatheter with oval or elliptical lumens
US5797869A (en)*1987-12-221998-08-25Vas-Cath IncorporatedMultiple lumen catheter
US5807329A (en)*1996-05-071998-09-15Gelman; Martin L.Displaceable catheter device
US6251084B1 (en)*1989-08-092001-06-26Medtronic Ave, Inc.Guide catheter and guidewires for effecting rapid catheter exchange
WO2002005701A3 (en)*2000-07-182002-05-30George P TeitelbaumAnti-occlusion catheter
US20040133156A1 (en)*2003-01-062004-07-08Diaz Joseph RobertBalloon catheter with improved resistance to non-deflation
US20050228339A1 (en)*2004-04-122005-10-13The Trustees Of The University Of PennsylvaniaMulti-lumen catheter
WO2007005734A2 (en)2005-07-012007-01-11C.R. Bard, Inc.Indwelling urinary drainage catheter
US20070071685A1 (en)*2003-12-222007-03-29Bracco Research S.A.Gas-filled microvesicle assembly for contrast imaging
EP2075014A2 (en)2002-05-242009-07-01Angiotech International AgCompositions and methods for coating medical implants
US20110009641A1 (en)*2005-06-152011-01-13Anderson Daniel GAmine-containing lipids and uses thereof
USD683016S1 (en)2011-12-012013-05-21Baylis Medical Company IncMedical device with lateral aperture
US20130331783A1 (en)*2010-12-162013-12-12Ams Research CorporationMicro-needle bladder balloon
US20140257243A1 (en)*2013-03-112014-09-11Covidien LpControlling catheter flow
US8969353B2 (en)2008-11-072015-03-03Massachusetts Institute Of TechnologyAminoalcohol lipidoids and uses thereof
US9193827B2 (en)2010-08-262015-11-24Massachusetts Institute Of TechnologyPoly(beta-amino alcohols), their preparation, and uses thereof
US9238716B2 (en)2011-03-282016-01-19Massachusetts Institute Of TechnologyConjugated lipomers and uses thereof
US9308281B2 (en)2011-06-082016-04-12Shire Human Genetic Therapies, Inc.MRNA therapy for Fabry disease
US9315472B2 (en)2013-05-012016-04-19Massachusetts Institute Of Technology1,3,5-triazinane-2,4,6-trione derivatives and uses thereof
US9333321B2 (en)2004-04-122016-05-10Aegis Medical Technologies, LlcMulti-lumen catheter
US9522176B2 (en)2013-10-222016-12-20Shire Human Genetic Therapies, Inc.MRNA therapy for phenylketonuria
US9629804B2 (en)2013-10-222017-04-25Shire Human Genetic Therapies, Inc.Lipid formulations for delivery of messenger RNA
US9713626B2 (en)2013-03-142017-07-25Rana Therapeutics, Inc.CFTR mRNA compositions and related methods and uses
US9840479B2 (en)2014-07-022017-12-12Massachusetts Institute Of TechnologyPolyamine-fatty acid derived lipidoids and uses thereof
US9850269B2 (en)2014-04-252017-12-26Translate Bio, Inc.Methods for purification of messenger RNA
US9957499B2 (en)2013-03-142018-05-01Translate Bio, Inc.Methods for purification of messenger RNA
US10022455B2 (en)2014-05-302018-07-17Translate Bio, Inc.Biodegradable lipids for delivery of nucleic acids
US10138213B2 (en)2014-06-242018-11-27Translate Bio, Inc.Stereochemically enriched compositions for delivery of nucleic acids
US10576166B2 (en)2009-12-012020-03-03Translate Bio, Inc.Liver specific delivery of messenger RNA
EP3626301A1 (en)2012-04-232020-03-25Aegis Medical Technologies, IncMulti-lumen catheter
US11173190B2 (en)2017-05-162021-11-16Translate Bio, Inc.Treatment of cystic fibrosis by delivery of codon-optimized mRNA encoding CFTR
US11174500B2 (en)2018-08-242021-11-16Translate Bio, Inc.Methods for purification of messenger RNA
US11224642B2 (en)2013-10-222022-01-18Translate Bio, Inc.MRNA therapy for argininosuccinate synthetase deficiency
US11253605B2 (en)2017-02-272022-02-22Translate Bio, Inc.Codon-optimized CFTR MRNA
EP3982851A4 (en)*2019-06-112023-08-16Dalent, LLCBalloon dilation device
US12156983B1 (en)2015-01-192024-12-03Dalent, LLCDilator device
US12195505B2 (en)2018-11-212025-01-14Translate Bio, Inc.Treatment of cystic fibrosis by delivery of nebulized mRNA encoding CFTR

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US2330399A (en)*1937-09-111943-09-28American Anode IncDistensible bag catheter
US2650801A (en)*1949-10-111953-09-01Michael B CollitoHeat exchanger

Cited By (124)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US3112748A (en)*1960-04-041963-12-03Pharmaseal LabSurgical tube
US3331371A (en)*1965-03-091967-07-18Prosit Service CorpCatheter having internal flow valve at distal end thereof
US3769980A (en)*1971-06-281973-11-06Medical Concepts IncMedical instruments
US3771527A (en)*1971-08-161973-11-13J RuisiSurgical drainage tube
US3773034A (en)*1971-11-241973-11-20Itt Research InstituteSteerable catheter
US4013077A (en)*1974-09-231977-03-22M.E.D.S. CorporationCollecting device
US4311140A (en)*1976-05-101982-01-19Henry BridgmanVacuum curet having an improved curetting opening
US4692141A (en)*1982-03-081987-09-08Mahurkar Sakharam DDouble lumen catheter
US4863424A (en)*1983-11-181989-09-05Blake Joseph W IiiTubular medical device and method of making and using the same
US5197951A (en)*1983-12-141993-03-30Mahurkar Sakharam DSimple double lumen catheter
US4770652A (en)*1985-02-121988-09-13Mahurkar Sakharam DMethod and apparatus for using dual-lumen catheters for extracorporeal treatment
US4808155A (en)*1986-02-271989-02-28Mahurkar Sakharam DSimple double lumen catheter
US4734094A (en)*1986-06-091988-03-29Jacob Erwin TCatheter and method for cholangiography
US4850982A (en)*1987-03-091989-07-25Erlich Brian HCatheter
US20010044594A1 (en)*1987-12-222001-11-22Vas-Cath IncorporatedMultiple lumen catheter
US6206849B1 (en)1987-12-222001-03-27Vas-Cath IncorporatedMultiple lumen catheter
US7229429B2 (en)1987-12-222007-06-12Vas-Cath Inc.Multiple lumen catheter
US5797869A (en)*1987-12-221998-08-25Vas-Cath IncorporatedMultiple lumen catheter
US4861337A (en)*1988-03-021989-08-29Sherwood Medical CompanyCollapsible urethral catheter
US4932959A (en)*1988-12-011990-06-12Advanced Cardiovascular Systems, Inc.Vascular catheter with releasably secured guidewire
US6251084B1 (en)*1989-08-092001-06-26Medtronic Ave, Inc.Guide catheter and guidewires for effecting rapid catheter exchange
US5318532A (en)*1989-10-031994-06-07C. R. Bard, Inc.Multilumen catheter with variable cross-section lumens
US5374245A (en)*1990-01-101994-12-20Mahurkar; Sakharam D.Reinforced multiple-lumen catheter and apparatus and method for making the same
US5221255A (en)*1990-01-101993-06-22Mahurkar Sakharam DReinforced multiple lumen catheter
US5360403A (en)*1990-05-161994-11-01Lake Region Manufacturing Co., Inc.Balloon catheter with lumen occluder
US5292315A (en)*1990-09-171994-03-08Scimed Life Systems, Inc.Low profile catheter for increasing lumen size of a blood vessel and guide wire therefor
US5195989A (en)*1990-09-171993-03-23Scimed Life Systems, Inc.Low profile catheter for increasing lumen size of a blood vessel and guide wire therefor
US5348536A (en)*1993-08-021994-09-20Quinton Instrument CompanyCoextruded catheter and method of forming
US5403291A (en)*1993-08-021995-04-04Quinton Instrument CompanyCatheter with elongated side holes
US5489278A (en)*1993-08-021996-02-06Quinton Instrument CompanyCatheter with elongated side openings
US5556390A (en)*1995-03-071996-09-17Quinton Instrument CompanyCatheter with oval or elliptical lumens
US5807329A (en)*1996-05-071998-09-15Gelman; Martin L.Displaceable catheter device
US6692459B2 (en)2000-07-182004-02-17George P. TeitelbaumAnti-occlusion catheter
US20040181191A1 (en)*2000-07-182004-09-16Teitelbaum George P.Anti-occlusion catheter
WO2002005701A3 (en)*2000-07-182002-05-30George P TeitelbaumAnti-occlusion catheter
EP2075014A2 (en)2002-05-242009-07-01Angiotech International AgCompositions and methods for coating medical implants
US20040133156A1 (en)*2003-01-062004-07-08Diaz Joseph RobertBalloon catheter with improved resistance to non-deflation
US7628784B2 (en)*2003-01-062009-12-08C. R. Bard, Inc.Balloon catheter with improved resistance to non-deflation
US20070071685A1 (en)*2003-12-222007-03-29Bracco Research S.A.Gas-filled microvesicle assembly for contrast imaging
US20050228339A1 (en)*2004-04-122005-10-13The Trustees Of The University Of PennsylvaniaMulti-lumen catheter
US7569029B2 (en)2004-04-122009-08-04Clark Timothy W IMulti-lumen catheter
US20090247927A1 (en)*2004-04-122009-10-01Clark Timothy W IMulti-lumen catheter
US9333321B2 (en)2004-04-122016-05-10Aegis Medical Technologies, LlcMulti-lumen catheter
US8517978B2 (en)2004-04-122013-08-27Aegis Medical Technologies, LlcMulti-lumen catheter
US10220184B2 (en)2004-04-122019-03-05Aegis Medical Technologies, LlcMulti-lumen catheter
US9006487B2 (en)2005-06-152015-04-14Massachusetts Institute Of TechnologyAmine-containing lipids and uses thereof
US20110009641A1 (en)*2005-06-152011-01-13Anderson Daniel GAmine-containing lipids and uses thereof
WO2007005734A2 (en)2005-07-012007-01-11C.R. Bard, Inc.Indwelling urinary drainage catheter
US8969353B2 (en)2008-11-072015-03-03Massachusetts Institute Of TechnologyAminoalcohol lipidoids and uses thereof
US10844028B2 (en)2008-11-072020-11-24Massachusetts Institute Of TechnologyAminoalcohol lipidoids and uses thereof
US10189802B2 (en)2008-11-072019-01-29Massachusetts Institute Of TechnologyAminoalcohol lipidoids and uses thereof
US11414393B2 (en)2008-11-072022-08-16Massachusetts Institute Of TechnologyAminoalcohol lipidoids and uses thereof
US9556110B2 (en)2008-11-072017-01-31Massachusetts Institute Of TechnologyAminoalcohol lipidoids and uses thereof
US10576166B2 (en)2009-12-012020-03-03Translate Bio, Inc.Liver specific delivery of messenger RNA
US9193827B2 (en)2010-08-262015-11-24Massachusetts Institute Of TechnologyPoly(beta-amino alcohols), their preparation, and uses thereof
US11786706B2 (en)2010-12-162023-10-17Boston Scientific Scimed, Inc.Micro-needle bladder balloon
US20130331783A1 (en)*2010-12-162013-12-12Ams Research CorporationMicro-needle bladder balloon
US10589070B2 (en)*2010-12-162020-03-17Boston Scientific Scimed, Inc.Micro-needle bladder balloon
US12390528B2 (en)2011-03-282025-08-19Massachusetts Institute Of TechnologyConjugated lipomers and uses thereof
US10933139B2 (en)2011-03-282021-03-02Massachusetts Institute Of TechnologyConjugated lipomers and uses thereof
US10117934B2 (en)2011-03-282018-11-06Massachusetts Institute Of TechnologyConjugated lipomers and uses thereof
US9238716B2 (en)2011-03-282016-01-19Massachusetts Institute Of TechnologyConjugated lipomers and uses thereof
US10888626B2 (en)2011-06-082021-01-12Translate Bio, Inc.Lipid nanoparticle compositions and methods for mRNA delivery
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US9597413B2 (en)2011-06-082017-03-21Shire Human Genetic Therapies, Inc.Pulmonary delivery of mRNA
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US10507249B2 (en)2011-06-082019-12-17Translate Bio, Inc.Lipid nanoparticle compositions and methods for mRNA delivery
US11052159B2 (en)2011-06-082021-07-06Translate Bio, Inc.Lipid nanoparticle compositions and methods for mRNA delivery
US10238754B2 (en)2011-06-082019-03-26Translate Bio, Inc.Lipid nanoparticle compositions and methods for MRNA delivery
US11951181B2 (en)2011-06-082024-04-09Translate Bio, Inc.Lipid nanoparticle compositions and methods for mRNA delivery
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