US20230390558A1 - System, method and catheter for pituitary and brain implantation - Google Patents

Abstract

The present invention relates to a system, its catheter and its method for providing electrical pulses and/or therapeutic or diagnostic liquids directly to a pituitary gland of a mammal. The catheter, containing an electrode or a microcannula or both, is moved through an endovascular route of a patient to his/her sinus cavernosus and then the distal end of the electrode or microcannula is moved through an opening in the distal end of the catheter and then through a perforation in the medial wall of the sinus cavernosus, to the pituitary gland.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS
• This application is a divisional under 35 U.S.C. § 121 of co-pending U.S. application Ser. No. 16/764,127 filed May 14, 2020, which is a 35 U.S.C. § 371 National Phase Entry Application of International Application No. PCT/NL2018/050765 filed Nov. 14, 2018, which claims benefit under 35 U.S.C. § 119(b) of NL Application No. 2019909 filed Nov. 14, 2017, the contents of which are incorporated herein by reference in their entireties.
FIELD OF THE INVENTION
• The present invention relates to a system for endovascular implantation of a catheter within a mammal body. The present invention particularly relates to a system for endovascular implantation of a catheter supplying electrical energy or therapeutic or diagnostic fluids or materials, such as stem cells, particularly to the pituitary gland, pituitary stalk, basal ganglia and/or hypothalamus of the brain.
BACKGROUND OF THE INVENTION
• It is known to implant a catheter, containing an electrode coupled to a source of electrical pulses, directly in a patient's brain, through the cerebral cortex, to modify their activity by deep brain stimulation. This can give relief to the symptoms of, for example, Parkinson's disease, depression and compulsive disorders. The catheter can also contain a tube for injecting a therapeutic or diagnostic liquid directly in the brain or neurological tissue to modify their activity, see for instance U.S. Pat. No. 7,505,807B1 and U.S. Pat. No. 8,116,883B2.
• Similarly, hormonal activity of glands, such as the pituitary, thymus and adrenal glands can be modified, using such a catheter to provide electrical pulses and/or therapeutic or diagnostic liquids directly to the glands, see for instance U.S. Pat. No. 8,515,542B2 and US2008065002A1.
• However, it has been a particularly difficult problem to provide electrical pulses and/or therapeutic or diagnostic liquids with a catheter directly to the pituitary gland, or to the pituitary stalk and hypothalamus via the pituitary gland. This is because the catheter has had to be inserted in the pituitary gland through the sphenoid sinus (the airy nasal cavity that is located before/under the sella) of the patients. The pituitary gland, which is in the sella, is separated from the sphenoid sinus by a layer of the dura mater (hard brain membrane), bone and mucous membrane of the nasal cavity.
• Providing electrical pulses and/or therapeutic or diagnostic liquids to the pituitary gland through the sphenoid sinus has therefore been difficult because the catheter has had to be inserted through the hard brain membrane, bone and mucous membrane of the nasal cavity. Also, the catheter has had to be inserted through the patient's nose which has posed a significant infection risk to the patient, as described for instance in U.S. Pat. No. 5,735,817 A.
• Furthermore, the catheter has had to be connected to a regulating device, which is approachable for maintenance and adjustment. Therefore, the catheter has had to be guided outside the nasal cavity to a suitable place for connection. A catheter coming out a person's nostril has been unappealing and has had a risk of easy dislocation. Therefore, the catheter has had to again be placed through mucous membrane and bone to enter a subcutaneous space in the face, from which it can be guided to the stimulating device.
• Because of the importance of the pituitary gland (which is the central hormone gland of the brain through which essential body functions, such as menstrual cycle, stress response, and paediatric growth are regulated), an alternative system has been sought for providing electrical pulses and/or therapeutic or diagnostic liquids and materials with a catheter directly to the pituitary gland and from there to the pituitary stalk (which is the connection between the hypothalamus and the pituitary) and the hypothalamus (which is a portion of the brain that links the nervous system to the endocrine system via the pituitary gland).
SUMMARY OF THE INVENTION
• This invention relates to a system for providing electrical pulses and/or therapeutic or diagnostic liquids directly or indirectly to a pituitary gland of a mammalian patient or to a pituitary stalk or to a hypothalamus of the mammalian patient via the pituitary gland, using a catheter that has a distal end movable distally through blood vessels, in an endovascular route, of the mammal and then into and through a sinus cavernosus of the mammal and that contains an action member, a distal end of which is movable distally within an elongated hollow tube of the catheter, the system being characterized by comprising, as an action member, an electrode and/or a microcannula having a distal end that can move:
• • distally, within the hollow tube of the catheter, through the endovascular route and then into and through the sinus cavernosus; and then
  • distally out of the catheter through an opening in the distal end of the catheter and then through a perforation in a medial wall of the sinus cavernosus to the pituitary gland and then to and into or under or around the pituitary gland;
  • wherein the system is capable of actively bending the hollow tube of the catheter to a predetermined angle of no less than 750 when moving along the endovascular route. Advantageously, the angle is at least 80°, more advantageously at least 85°, yet more advantageously at least 90°.
• Advantageously, the system is operable to move the distal end of the action member, within the hollow tube of the catheter, via the endovascular route from a vena jugularis of the mammal, to an inferior or superior petrosal sinus of the mammalian patient, and then to the sinus cavernosus of the mammalian patient. More advantageously, the distal end of the catheter moves via the endovascular route from the ileac vein or femoral vein in a groin or the cephalic vein in the arm of the mammalian patient where the catheter is inserted in the mammalian patient.
• Also advantageously, the catheter of the system comprises an exterior lumen within the hollow tube of the catheter and an interior lumen within the exterior lumen, the exterior lumen containing a first steering mechanism and the interior lumen containing a second steering mechanism, and the first and second steering mechanisms being operable to actively bend the hollow tube to a predetermined angle of no less than 75°.
• Also advantageously, the catheter of the system has an action member comprising a push wire having a distal end that can move:
• • distally, within the hollow tube of the catheter, through the endovascular route and then into and through the sinus cavernosus; and then;
  • distally out of the catheter through the opening in the distal end of the catheter and then through the perforation in the medial wall of the sinus cavernosus.
    More advantageously, the distal end of the push wire comprises a tip containing a sharp, advantageously pointed, element that can be projected distally from the opening in the distal end of the catheter to form the perforation in the medial wall of the cavernous sinus.
• Also advantageously, a distal-most part of the catheter of the system includes a malleable cushion to allow good contact of the distal-most part with the surface of the medial wall of the sinus cavernosus. Also advantageously, the exterior of a distal part of the catheter, advantageously between the collar and the cushion, has a radiopaque ring that can be recognized, and made visible, by an imaging device, such as an X-ray, fluoroscopy, angiogram, MRI or a CT-scan device to facilitate proper positioning of the distal part of the catheter in the patient. (This visibility or recognition ability is further referred to herein as “radiopacity”). Additionally or alternatively, a distal part of the catheter, advantageously between the collar and the cushion, contains one or more electromagnetic localizers to facilitate proper positioning of the distal part in the patient. Each localizer is part of a tracking system, in which the localizer includes a transmitter and receiver coil array, enabling it to transmit electromagnetic signals and receive electromagnetic energy from a transmitter coil array. The transmitter coil can suitably be located in, or adjacent to, the patient and can generate an electromagnetic field to energize each localizer.
• Also advantageously, the exterior of the distal end of the catheter of the system, adjacent to, and proximal of, the cushion, has an annular collar that can be inflated, so that distal surfaces of the collar are projected distally from the distal end of the catheter around the perforation in the medial wall of the cavernous sinus to close a space around the opening in the distal end of the catheter between the distal end of the catheter and the perforation, advantageously before the tip of the push wire is projected distally from the opening in the distal end of the catheter to form the perforation in the medial wall of the cavernous sinus. More advantageously, the exterior of the distal end of the catheter, adjacent to, and proximal of, the inflatable annular collar, also has a stabilizing device, to secure the position of the distal end of the catheter within the perforation in the medial wall of the sinus cavernosus, without occluding the perforation, the stabilizing device comprising an inflatable tripod, provided circumferentially about the exterior of the catheter and having inflatable, radially extendable legs.
• Also advantageously, the catheter of the system comprises a third steering mechanism comprises guide wire within the hollow tube for pivoting or steering the distal end of the catheter in a desired direction, advantageously by remote control, for controlling its distal movement through the endovascular route and then into and through the sinus cavernosus.
• Also advantageously: the catheter of the system has an action member comprising an electrode, the distal end of which has one or more contact points for electrical stimulation of endocrine tissue of the pituitary gland, the pituitary stalk or the hypothalamus; and/or the one or more action members comprise a microcannula, the distal end of which has one or more central or wall-located hollow channels, each with one or more side openings, through which small volumes of a fluid or gel can flow into the pituitary gland, the pituitary stalk or the hypothalamus, still more advantageously with side openings that can be opened and closed by remote control. Advantageously, the electrode comprises one or more penetrating electrodes, one or more surface area electrodes, or a combination of both. More advantageously, the electrode design and electrode placement is such that a focal electrical field is generated.
• The electrode is advantageously adapted to: electrically stimulate the pituitary gland to produce and secrete adrenocorticotropic hormone (ACTH) and/or alpha-melanocyte stimulating hormone (MSH) and/or oxytocin; and/or electrically stimulate the pituitary gland to stimulate the magnocellular nuclei of the anterior hypothalamus through axons that descend through the pituitary stalk to the pituitary gland. Also more advantageously, distal portions of the electrode or microcannula or both have a form memory and thus can form a three-dimensional shape, such as a circle, oval or helix, within or about the pituitary gland, advantageously when triggered by remote control. Still more advantageously, distal portions of the electrode, when inserted in the pituitary gland, have a coil shape within the pituitary gland.
• Also advantageously, the catheter of the system, particularly its hollow tube, has a peel-away configuration, so that an electrode or microcannula can subsequently be removed from the patient through the catheter in such a way, that the electrode or microcannula remains intact.
• This invention also relates a catheter, advantageously the catheter of the system of the invention, for providing electrical pulses and/or therapeutic or diagnostic liquids directly to a pituitary gland of a mammal or to a pituitary stalk or to a hypothalamus of the mammal via the pituitary gland, a distal end of the catheter containing one or more action members, a distal end of each of which can move distally in the catheter via blood vessels of an endovascular route of the mammal and then via a sinus cavernosus of the mammal to a medial wall of the cavernous sinus; the catheter being characterized by: the one or more action members comprising a push wire having a distal end having a tip with a sharp, advantageously pointed, element that can be projected distally from an opening in the distal end of the catheter to form a perforation in the medial wall of the cavernous sinus, through which: a distal end of another action member, advantageously an electrode or a microcannula or both can be moved distally through the cavernous sinus and the electrode and/or microcannula can then be inserted in, or under/around the pituitary gland from the distal end of the catheter.
• This invention further relates to a method for providing electrical pulses and/or therapeutic or diagnostic liquids directly to a pituitary gland of a mammal or to a pituitary stalk or to a hypothalamus of the mammal via the pituitary gland, comprising the steps of:
• • moving a distal end of a catheter, advantageously the catheter of the system of this invention, that contains one or more action members, a distal end of each of which is movable distally within the catheter, through an endovascular route of the mammal from a vena jugularis of the mammal, to an inferior or superior petrosal sinus of the mammal, and then to a sinus cavernosus of the mammal; and then
  • perforating a medial wall of the cavernous sinus to the pituitary gland; and then
  • moving the distal end of the one or more action members distally from the catheter, through an opening in the distal end of the catheter and through the perforated medial wall of the sinus cavernosus, to the pituitary gland.
    Advantageously, the distal end of each of the one or more action members moves via the endovascular route from the ileac vein or femoral vein in a groin or the cephalic vein in the arm of the mammal where the catheter is inserted in the mammal.
• This invention yet further relates to a method of treating endocrinological medical conditions related to the components of the endocrine system such as the adrenal glands, pituitary gland, and hypothalamus with the system and the catheter of this invention. Non-limiting examples of such endocrinological conditions include hypoglycemia, diabetes type I and II, obesity, hyperthyroidism, hypothyroidism, amenorrhea, dysmenorrhea, infertility, impotence, anorgasmia, delayed orgasm, perimenstrual syndrome, hypercholesterolemia, hypertriglycridinemia, Cushing's disease, Addison's disease, Addison's crisis, malabsorption syndrome, dysautonomia, chronic fatigue syndrome, fatigue, heat exhaustion, cold extremities, hot flashes, vasomotor instability, Raynaud's syndrome, hormonal disorders, metabolic disorders such as gout, disorders of metabolism and metabolic storage diseases where there is an accumulation of abnormal amounts of various substances such as glycogen in glycogen storage diseases, iron in hemochromatosis or copper in Wilson's disease, auto-immune disorders, sleep disorders and disruptions in the circadian rhythm. In particular, the invention relates to the treatment of Adison's disease and Adison's crisis.
• Typical treatment for Adison's disease involves replacing the absent hormones by administration of a corticosteroid such as hydrocortisone and fludrocortisone, which needs to be applied in relatively large amounts, and potentially requiring a lifelong, continuous steroid replacement therapy, with regular follow-up treatment and monitoring for other health problems. In the case of a crisis, an injection of corticosteroid is usually required. Without treatment, an adrenal crisis can result in death.
• However, the treatment method of this invention now permits triggering of the patient's own production of steroid hormones by triggering the feedback loop in the patient's own pituitary gland, or even the patient's hypothalamus, e.g., by in situ administration of CRH or a useful analogue thereof, or a combination of CRH with other pharmacologically active components like vasopressin, or focal electrical stimulation.
• This invention still further relates to a method of treating, with the system and the catheter of this invention, pain, pain perception, post-traumatic stress disorder, epilepsy, depression, anxiety disorders, and other similar conditions through stimulation of the posterior lobe of the pituitary gland, the intermediate lobe, the anterior lobe of the pituitary gland, or a combination of these.
BRIEF DESCRIPTION OF THE DRAWINGS
• The following exemplary drawings illustrate preferred embodiments of the invention. Other objects and features will be apparent from the following description and drawings in which the following figures disclose as follows:
• FIG.1 A schematic illustration of a preferred embodiment of this invention: flexible catheter1 containing a flexible guide wire2 and having an opening at its distal end, through which the guide wire extends distally.
• FIG.2 The catheter ofFIG.1, showing, within it: i) an action member5, e.g., an electrode or a microcannula, with its distal end in communication with the opening in the distal end of the catheter and ii) a guidewire steering system6 with its proximal end connected to the proximal end of the catheter.
• FIG.3 The catheter ofFIG.1, showing, within it: i) its action member5 and ii) itssteering system6 with its distal end connected to the distal end of the catheter; and showing on its distal end: i) its collar deflated10, ii) itsmalleable cushion8 with an annular radiopaque and electro-stimulating ring7 about it, and iii) its elastic, stretchable and radiopaque annular cuff9 around a distally-extending central opening that is in communication with the opening in the distal end of the catheter, through distally-extending central openings (not shown) in thecollar10 andcushion8.
• FIG.4 The catheter ofFIG.3, showing its distal end moved adjacent the medial wall of the sinus cavernosus with: i) itscollar10 deflated and ii) itscushion8 in contact with themedial wall11 of the sinus cavernosus.
• FIGS.5 and6 he catheter ofFIG.4, showing: i) itscollar10 distally subsequently inflated against themedial wall11 of the sinus cavernosus and ii) itscushion8 then moved proximally towards themedial wall11 of the sinus cavernosus.
• FIG.7 The catheter ofFIGS.5 and6, showing: i)) itscollar10 distally inflated against themedial wall11 of the sinus cavernosus and ii) itscushion8 subsequently moved distally against the medial wall of the sinus cavernosus by applying suction to the proximal end of the catheter to suck venous blood out of thespace12 between the distal end of the catheter and themedial wall11 of the sinus cavernosus through the central openings in thecollar10,cushion8 and elastic cuff9 of the catheter.
• FIG.8 The catheter ofFIG.3, showing apush wire13 extending distally through the catheter and through the central openings in its collar, cushion and cuff and with a sharp, perforating tip at the distal end of the push wire; the tip extends distally out of the catheter through the central opening in the cuff, so that the tip can perforate the medial wall of the sinus cavernosus; the diameter of the push wire is smaller than the guide wire2.
• FIG.9 The push wire ofFIG.8, showing its sharp, perforating tip at its distal end.
• FIG.10 The catheter ofFIG.7 showing: i) its cushion in contact with the medial wall of the sinus cavernosus and ii) anendovascular action member15 extending outwardly of the distal end of the catheter and through the central openings in its collar, cushion and cuff and then through a perforation in the medial wall of the sinus cavernosus to the pituitary gland. for subdural treatment thereof.
• FIG.11 The catheter ofFIG.10, showing: i) its cushion moved away from the medial wall of the sinus cavernosus and ii) theendovascular action member15 extending distally through the catheter and its collar, cushion and cuff and outwardly of the opening in the distal end of the catheter and through the central openings in its collar, cushion and cuff and then through a perforation in themedial wall11 of the sinus cavernosus to thepituitary gland16 for subdural treatment thereof.
• FIG.12 The catheter ofFIG.11, showing an anchoringfoam17, used to seal the opening in themedial wall11 of the sinus cavernosus around theendovascular action member15 extending outwardly of the opening in the distal end of the catheter and through the central openings in its collar, cushion and cuff and then through the opening in the medial wall of the sinus cavernosus to the pituitary gland.
• FIG.13 The catheter ofFIG.12, showing the anchoringfoam17, used to seal the opening in themedial wall11 of the sinus cavernosus around asecond guiding catheter18, releasing afurther action member15 extending upwardly of the opening in the distal end of the second catheter through thepituitary gland16 into thepituitary stalk19.
• FIG.14 The path of the distal end of anendovascular electrode24, as an action member, that has been moved within the catheter ofFIGS.1 to12 via the vena jugularis and then via the inferior or superior petrosal sinus to the sinus cavernosus.
• FIG.15 The path of the distal end of theendovascular electrode24 ofFIG.14 that has then been moved distally, from the distal end of the catheter, then moved through a perforation in the medial wall of the sinus cavernosus and then been inserted into thepituitary gland16.
• FIG.16 The path of the distal end of theendovascular electrode24 ofFIG.15 that has then been moved through thepituitary gland16, then steered vertically and then inserted into, or parallel to, the pituitary stalk.
• FIG.17 The path of the distal end of theendovascular electrode24 ofFIG.16 that has then been steered further vertically, then passed through, or parallel to, the pituitary stalk and then being inserted into the core of the hypothalamus.
• FIG.18 The path of the distal end of theendovascular electrode24 ofFIG.15 that has then formed a coil inside thepituitary gland16.
• FIG.19 A stabilizingdevice28 on the exterior of the distal end of the catheter ofFIG.8 to secure the position of the distal end of the catheter within the perforation in the medial wall of the sinus cavernosus, without occluding the perforation.
• FIG.20 The catheter ofFIG.19 showing: theendovascular electrode24 ofFIG.14 then moving distally, from the distal end of the catheter, then moving through the medial wall of the sinus cavernosus and then extending through an opening in the medial wall of the sinus cavernosus to either just beneath the pituitary gland for subdural treatment thereof or inserted in the surface of the pituitary gland for epidural treatment thereof.
DETAILED DESCRIPTION OF THE INVENTION
• Herein, the term “an action member” preferably means one or more electrodes or one or more microcannulas or one or more push wires or any or some or all of them within a catheter.
• Also herein, the term “guide wire” preferably means a tiny elongated wire designed to navigate a vessel to reach a segment of the vessel. Once the tip of the wire arrives at its destination, it acts as a guide that a larger catheter can rapidly follow for easier delivery to the destination. Such wires are characterized by their pushability, steerability, torque and opacity.
• Pushability is the amount of force needed to advance the wire. Steerability is the ability and responsiveness of the wire tip to navigate vessels. Torque is the response of the wire to turning by the operator when navigating vessels. Opacity is its level of visibility under fluoroscopic imaging.
• Also herein, the term “catheter” preferably means an elongated hollow flexible tube, made from a medical grade material, for insertion into a vessel. The tube makes it easier to enter the vessel and move within it with other devices or instruments, such as lasers, stents, and balloons for angioplasty.
• Also herein, the term “microcannula” preferably means an elongated thin tube, the distal end of which can penetrate one or more cells of a mammalian patient. A microcannula with a capillary tube has a bore thin enough to deliver a minute drop of a liquid to a single cell penetrated by the microcannula and thereby treat, e.g., stimulate, the single cell or multiple cells by allowing injected fluid to diffuse among the cells. A microcannula which is not a capillary tube can be used to hold a movable push wire and/or provide air pressure for inflation/deflation, an anchoring foam, and/or other elements to manipulate elements at the distal end of the catheter. Each microcannula can be extended through the elongated hollow tube of the catheter and subsequently retracted from the catheter through its elongated hollow tube.
• Also herein, the term “distal end” preferably means the portions of a catheter or any of its action members at their distal extremities and their parts adjacent their distal extremities.
• Also herein, the terms “mammalian patient” and “mammal” are used interchangeably and preferably mean a human or mammalian animal, such as a dog, particularly a human, in need of treatment.
• Also herein, the term “femoral vein” preferably includes the inferior margin of the inguinal ligament which is known as the external iliac vein and is below the inguinal ligament.
• Also herein, the term “endocrinological medical condition” preferably means a problem related to the components of the endocrine system, such as the adrenal glands, pituitary gland, and hypothalamus, including hypoglycemia, diabetes type I and II, obesity, hyperthyroidism, hypothyroidism, amenorrhea, dysmenorrhea, infertility, impotence, anorgasmia, delayed orgasm, perimenstrual syndrome, hypercholesterolemia, hypertriglycridinemia, Cushing's disease, Addison's disease, Addison's crisis, malabsorption syndrome, dysautonomia, chronic fatigue syndrome, fatigue, heat exhaustion, cold extremities, hot flashes, vasomotor instability, Raynaud's syndrome, hormonal disorders, metabolic disorders such as gout, disorders of metabolism and metabolic storage diseases where there is an accumulation of abnormal amounts of various substances such as glycogen in glycogen storage diseases, iron in hemochromatosis or copper in Wilson's disease, auto-immune disorders, sleep disorders and disruptions in the circadian rhythm. In particular the present invention relates to the treatment of Adison's disease and Adison's crisis, as well as pain, pain perception, post-traumatic stress disorder, depression and anxiety.
• The system of this invention, as shown inFIGS.1-12, provides electrical pulses and/or therapeutic or diagnostic liquids to a pituitary gland of a mammalian patient or to a pituitary stalk or to a hypothalamus of the mammalian patient directly or indirectly (i.e., subdurally) as shown inFIGS.10 and11 or indirectly (epidurally), i.e., about or adjacent or beneath or above the pituitary gland, pituitary stalk or the hypothalamus as shown inFIG.20. The system uses a catheter1 that has a distal end movable distally through one or more blood vessels of an endovascular route of the mammal. Through the catheter, one ormore action members5 or15, preferably one ormore electrodes5 or15 or one or more microcannulas5 or15 or one ormore push wires13 or any or some or all of them may be inserted, a distal end of each of which is movable distally within the catheter1 and, via the catheter, through the endovascular route and then into and through the sinus cavernosus of the mammal.
• The system preferably comprises an electrode array is provided for interfacing with the organ tissue in situ, the device comprising: a. a deformable array of electrodes comprising a plurality of electrodes in electrical communication with a plurality of deformable electrical interconnects and a connector line; wherein the deformable array of electrodes provides a net bending stiffness of the array low enough that the device is capable of establishing conformal contact with the tissue in situ; and b. a connection plug provided at the proximal end of the connector line of the electrode array provided with a distal end of which can be attached to a bone adjacent the organ, such an anterior wall of the sphenoid sinus/vomer, and a proximal end of which can be reversibly connected electrically to a wire that is connected electrically to a source of electrical stimulation for the organ.
• The catheter1 of the system shown inFIGS.1-12 contains one or more microcannula orelectrodes5 or15, as action members, extending through its elongated hollow tube. At least one of the action members has a distal end that can move:
• • distally within the catheter, through the endovascular route and then into and through the sinus cavernosus; and then
  • distally out of the catheter, through an opening in the distal end of the catheter and then through a perforation in the medial wall of the sinus cavernosus to the pituitary gland and then to and into the pituitary gland, preferably when the distal end of the catheter is adjacent the medial wall of the sinus cavernosus.
• The catheter1 of the system shown inFIGS.1-12 can also contain, in its elongated hollow tube, one or moreadditional microcannula5 or15, through which can be provided amovable push wire13 and/or air pressure for inflation/deflation (e.g., of thecollar10 or a stabilizing device28), an anchoringfoam17, and/or other elements to manipulate elements at the distal end of the catheter, such as thecollar10 or the ring7. Alternatively, thepush wire13, air pressure for inflation/deflation, an anchoring foam, or other elements to manipulate elements at the distal end of the catheter can be provided directly through the elongated hollow tube of the catheter, Preferably, thepush wire13 has a distal end that can move:
• • distally, within anadditional microcannula5 or15 in the catheter, through the endovascular route and then into and through the sinus cavernosus; and then
  • distally out of the additional microcannula and the catheter through an opening in the distal end of the catheter and then through the perforation in the medial wall of the sinus cavernosus.
    The distal end of thepush wire13 preferably has atip14 with a sharp, preferably pointed,distal element14 that can be projected distally, through the opening in the distal end of the catheter, to perforate the medial wall of the sinus cavernous. Also preferably, the tip of the catheter has one or more conventional sensors or a Doppler probe to allow identification of cranial nerves or arteries.
• Preferably, the elongated hollow tube of the catheter1 of the system also contains a flexible guide wire2, preferably with a blunt and atraumatic distal end, to guide the catheter through the endovascular route and and then into and through the sinus cavernosus. The distal end of the guide wire can be provided with a Doppler probe to identify the carotid artery and/or with an electrical stimulation device for identification of the abducens nerve.
• Preferably, one or more action members of the catheter1 of the system are located within the elongated hollow tube of the catheter. A conventional catheter1 containing one or moreconventional microcannula5 or15 can be used in this system. Each microcannula can: i) contain an electric wire for carrying a pulsed current to an electrode5 or15 (not shown) at the distal end of the catheter for providing electrical stimulation, at the distal end of the catheter or ii) carry a diagnostic or therapeutic liquid to the distal end of the catheter. Preferably, the microcannula for carrying a diagnostic or therapeutic liquid is a microcannula with a capillary tube. Also preferably, the distal end of each electrode has one or more contact points for electrical stimulation of endocrine tissue of the pituitary gland, the pituitary stalk or the hypothalamus. Also preferably, the distal end of each microcannula for a liquid has one or more side openings which are in communication with the microcannula's central hollow channel and through which:
• • small volumes of a fluid or gel can flow from a microcannula into the pituitary gland, the pituitary stalk or the hypothalamus, still more preferably with side openings that can be opened and closed by remote control; and/or
  • small volumes of a pressurized gas can flow from a microcannula into thecollar10 to inflate it, so that distal surfaces of the collar are projected distally from the distal end of the catheter around a perforation in the medial wall of the cavernous sinus to close a space around the opening in the distal end of the catheter between the distal end of the catheter and the perforation, preferably before the tip of the push wire is projected distally from the opening in the distal end of the catheter to form the perforation in the medial wall of the cavernous sinus.
• Also preferably, an annular radiopaque collar or ring7 is provided on a distal part of the exterior of the tubular wall of the catheter1 of the system, spaced away from the distal end of the catheter. The ring7 allows the position of the distal part of the catheter to be identified with X-ray, MRI or CT-scan.
• Also preferably, the distal end of the tubular wall of the catheter1 of the system holds acushion8 that allows the distal end of the catheter to have good, preferably liquid tight, contact with the surface of the medial wall of the sinus cavernosus and thereby prevent venous blood from the cavernous sinus leaking into the sella or in or around the pituitary gland. The exterior of the distal end of the catheter, adjacent to, and proximal of, thecushion8, is preferably provided with the radiopaque ring7. Within thecushion8 is preferably a central stretchable, elastic cuff9, which at rest closes the opening in the distal end of the catheter1, but can be stretched to allow movement, through its full diameter, of the push wire,13 and/or subsequently a sealing plug or the anchoringfoam17. In this regard, thesharp tip14 of thepush wire13 can be projected distally from the distal end of the catheter, through the opening, in thecushion8 to perforate the medial wall of the cavernous sinus, and subsequently to force the anchoring foam distally from the catheter into the perforation made by the sharp element to close the perforation.
• Also preferably, the exterior of a distal part of the catheter1 of the system, adjacent to, and proximal of, the ring7, is provided with aninflatable collar10, which is flush with the outer surface of the tubular wall of the catheter when deflated. The ring7 is preferably between thecollar10 and thecushion8.
• Also preferably, a distal part of the catheter1 of the system, preferably between thecollar10 and thecushion8, contains one or more electromagnetic localizers (not shown) to facilitate proper positioning of the distal part in the patient. Each localizer is part of a tracking system, in which the localizer includes a transmitter and receiver coil array, enabling it to transmit electromagnetic signals and receive electromagnetic energy from a transmitter coil array. The transmitter coil can suitably be located in, or adjacent to, the patient and can generate an electromagnetic field to energize each localizer. Suitable localizers and tracking systems include, for instance, those described in U.S. Pat. No. 8,549,732 B2 and U.S. Pat. No. 9,717,442 B2.
• Also preferably, the catheter1 of the system includes an integrated steering system, such as a guide wire within the elongated hollow tube of the catheter for pivoting or steering the distal end of the catheter, preferably byremote control6 at the proximal end of the catheter, in a desired direction for distal movement through the endovascular route and then into and through the sinus cavernosus. More preferably, the catheter has a conventional steering system which can actively bend the hollow tube of the catheter to a predetermined angle of no less than 75°. Yet more preferably, the catheter has an exterior lumen within the hollow tube of the catheter and an interior lumen within the exterior lumen. The exterior lumen contains a first steering mechanism, and the interior lumen contains a second steering mechanism, that the first and second steering mechanisms being operable to actively bend the hollow tube to a predetermined angle of at least 80°, more preferably at least 85°, yet more preferably at least 90°, when moving the distal end of the catheter along the endovascular route. Such a catheter steering mechanism is described, for instance, in U.S. Pat. No. 8,152,756 B2, US8715226B2 and US20050203413A1.
• Also preferably, the exterior of the distal end of the catheter1 of the system, adjacent to, and proximal of, the inflatable annular collar, also has a stabilizingdevice28, shown inFIG.19, to secure the position of the distal end of the catheter within the perforation in the medial wall of the sinus cavernosus, without occluding the perforation. Preferably, the stabilizingdevice28 comprises an inflatable tripod29, provided circumferentially about the exterior of the catheter and having inflatable, radiallyextendable legs30. Preferably, the stabilizingdevice28 is connected to a source of air pressure (not shown), via amicrocannula5 or15 or via the hollow tube of the catheter, which can inflate thelegs30 of the device.
• Also preferably, distal portions of each electrode ormicrocannula5 or15 of the catheter1 of the system have a form memory and thus can form a three-dimensional shape, such as a circle, oval or helix, within or about/around the pituitary gland, preferably when triggered by remote control. Still more preferably, distal portions of each electrode or microcannula, when inserted in the pituitary gland, have a coil shape within the pituitary gland.
• Also preferably, a distal part of the catheter1 of the system, particularly its hollow tube, has a conventional peel-away configuration (not shown), so that the catheter can be removed from a mammalian patient after it has been used to insert an electrode ormicrocannula5 or15 in the patient, so that the electrode or microcannula remains intact and properly positioned in the patient. A suitable peel-away configuration includes, for instance, those described in U.S. Pat. No. 7,697,996B2.
• Also preferably, the distal end of the catheter1 of the system, containing one or more electrodes and/or one or more microcannulas5 or15, is moved through the endovascular route from the vena jugularis of the mammalian patient, then to the inferior or superior petrosal sinus of the mammal, and then to the sinus cavernosus of the mammal, where as shown inFIG.14 are the superiorophthalmic vein19, inferiorophthalmic vein20,Basilar plexus21, inferiorpetrosal sinus22, jugular vein23, endovascularpituitary electrode24, superiorpetrosal sinus25,cavernous sinus26 and circularvenous plexus27. More preferably, the distal end of the catheter is moved through the endovascular route from the ileac vein or femoral vein in a groin of the mammal where the catheter has been inserted in the mammal. The distal end of an electrode or microcannula is then moved distally out of the catheter, through the opening in the distal end of the catheter, and through the medial wall of the sinus cavernosus and is then inserted subdurally into thepituitary gland16 as shown inFIGS.15 and20 or positioned epidurally of the pituitary gland as shown inFIG.20. In this regard,FIG.20 particularly shows the trajectory of anelectrode24 being either epidurally placed adjacent a surface of the pituitary gland16 (at31) or subdurally inserted into the surface of the pituitary gland16 (at32). The distal end of the subdurally placed electrode ormicrocannula5 or15 can then be moved through the pituitary gland, then steered to move vertically and then inserted into the pituitary stalk as shown inFIG.16. The distal end of the electrode or microcannula can then be steered further vertically, then passed through thepituitary stalk25 and then inserted into the core of the hypothalamus as shown inFIG.17. In this regard:
• • the catheter1 can be pressed against themedial wall11 of the cavernous sinus as shown inFIG.4; thereby, thecushion8 is pressed against the surface of themedial wall11 of the sinus cavernosus; thecollar10 can then be inflated as shown inFIGS.5 and6 to thereby seal off
  • the space around the distal end of the catheter; inflation and deflation of thecollar10 can be done through amicrocannula5 or15 or directly through the elongated hollow tube of the catheter;
  • to allow full contact of thecushion8 at the distal end of the catheter with themedial wall11 of the sinus cavernosus, the pressure in the sealedspace12 can then be reduced as shown inFIG.7 by applying suction through a microcannula or through the catheter; thereby, themedial wall11 of the cavernous sinus is pulled against thecushion8 to provide full contact between the two;
  • the medial wall of the cavernous sinus can then be perforated with the sharppointed tip14 of thepush wire13 shown inFIGS.8 and9; in this regard, thetip14 is preferably shallow, e.g., only 1 mm long, so if the wall of the carotid artery is accidently touched, the tip will not cause full thickness injury of the carotid wall.
  • a pituitary electrode ormicrocannula5 or15 can then be inserted, via the catheter into thepituitary gland16 as shown inFIGS.10 and11 for subdural treatment of the pituitary gland or alternatively under or around the pituitary gland for epidural treatment of the pituitary gland as shown inFIG.20. Because the pressure in the sealedspace12 has been reduced, themedial wall11 of the cavernous sinus continues to adhere to thecushion8 at the distal end of the catheter;
  • when the pressure in the sealedspace12 is subsequently allowed to normalize, themedial wall11 of the cavernous sinus takes its normal anatomical position, which allows some space between it and thecushion8; therefore, the sealedspace12 can then be filled with an anchoringfoam17, supplied by anadditional microcannula5 or15, as shown inFIG.13 or directly through the elongated hollow tube of the catheter to form a cast of the sealedspace12; the anchoring foam may then also seep through the perforation of themedial wall11 of thecavernous sinus17;
  • thecollar10 can be deflated and the catheter1 can be pulled away from themedial wall11 of the cavernous sinus, leaving the electrode/microcannula5 or15 fixed in place by the anchoringfoam17 and safely inserted into/around/under thepituitary gland16; the anchoringfoam17 effectively sealing the medial wall of the cavernous sinus, preventing venous blood of the cavernous sinus to seep in the space betweenmedial wall11 andpituitary gland16; and then
  • a stabilizingdevice28 as shown inFIG.19, on the exterior of the distal end of the catheter1, can be used to secure the position of the distal end of the catheter within the perforation in the medial wall of the sinus cavernosus, without occluding the perforation; preferably, the stabilizingdevice28 includes an inflatable tripod29, provided circumferentially about the exterior of the catheter and having inflatable, radiallyextendable legs30.
• The catheter1 of this invention can provide electrical pulses and/or therapeutic or diagnostic liquids directly to a pituitary gland of a mammal or to a pituitary stalk or to a hypothalamus of the mammal via the pituitary gland. The catheter contains one or more, conventional action members, a distal end of each of which can be moved in a conventional manner distally within the catheter through one or more blood vessels of the mammal and then via a sinus cavernosus of the mammal to a medial wall of the cavernous sinus. The catheter features:
• • an action member that is a push wire, a distal end of which has a tip with a sharp, preferably pointed, element that can be projected distally from an opening in the distal end of the catheter to form a perforation in the medial wall of the cavernous sinus, through which perforation the distal end of one or more other action members, preferably one or more electrodes and/or microcannulas, can be moved distally through the cavernous sinus and the one or more other action members can then be inserted in the pituitary gland from the distal end of the catheter.
• Preferably a distal-most part of the catheter includes a malleable cushion to allow good contact of the distal-most part with the surface of the medial wall of the sinus cavernosus. Also preferably, the exterior of the distal end of the catheter, adjacent to, and proximal, of the cushion contains an annular collar that can be inflated, so that distal surfaces of the collar are projected distally from the distal end of the catheter around the perforation in the medial wall of the cavernous sinus to close a space around the opening in the distal end of the catheter between the distal end of the catheter and the perforation, preferably before the tip of the push wire is projected distally from the opening in the distal end of the catheter to form the perforation in the medial wall of the cavernous sinus. Also preferably, the exterior of the distal end of the catheter, preferably between the collar and the cushion, is provided with a ring that contains a radiopaque marking that can be recognized by X-ray, fluoroscopy, angiogram, MRI or a CT-scan. Also preferably, the distal end of the catheter can be pivoted or steered in a desired direction, preferably by remote control, for controlling its distal movement through the endovascular route and then into and through the sinus cavernosus.
• The method of this invention provides electrical pulses and/or therapeutic or diagnostic liquids directly to a pituitary gland of a mammal or to a pituitary stalk or to a hypothalamus of the mammal via the pituitary gland, comprising the steps of: moving a distal end of a catheter that contains one or more action members, preferably, preferably one or more electrodes and/or microcannulas, a distal end of each of which is movable distally within the catheter, through an endovascular route of the mammal route from the vena jugularis of the mammal, to the inferior or superior petrosal sinus of the mammal, and then to the sinus cavernosus of the mammal; and then forming a perforation in the medial wall of the cavernous sinus to the pituitary gland; and then moving the distal end of each of the one or more action members distally from the catheter through an opening in the distal end of the catheter and then through the perforation in the medial wall of the sinus cavernosus, to the pituitary gland, preferably when the distal end of the catheter is adjacent the medial wall of the sinus cavernosus.
• Preferably, the distal end of the catheter moves via one or more blood vessels of an endovascular route from the ileac vein or femoral vein in a groin or the cephalic vein in the arm of the mammal where the catheter is inserted in the mammal.
• With this system, its catheter and its method, one ormore electrodes5 or15 can be connected to a subcutaneous pulse generator and/or one or more microcannulas5 or15 can be connected to a source of a therapeutic liquid, such as a pump and reservoir for regulatory hormones or proteins, RNAs, stem cells, cells that produce therapeutic substances, viruses, cells that can modify native pituitary gland cells and pharmaceutical compositions/drugs, and each electrode and/or microcannula can be implanted more safely in the pituitary gland, the pituitary stalk or the hypothalamus of a mammal patient for temporary or permanent stimulation thereof. In this regard, endovascular access to the basic core of the brain in accordance with this invention is simpler than via the cerebral cortex and safer and easier than via the sinus sphenoidalis. By treating the pituitary gland in this way with electrical pulses and/or therapeutic liquids, it is believed that: pituitary functions could be stimulated or inhibited, as desired, and problems of infertility, epilepsy, morbid obesity, and type II diabetes could be treated; and symptoms and diseases of the pituitary gland (e.g., Cushing's disease or Growth Hormone deficiency), as well as general disorders (type II diabetes, adipositis and infertility) in which the pituitary gland is involved, could be treated.
• In particular, the distal end of each of the one ormore electrodes5 or15 can be used to electrically stimulate the anterior and intermediate lobe of the pituitary gland to produce and secrete ACTH and/or MSH. The distal end of each electrode can also be used to electrically stimulate the posterior lobe of the pituitary gland and thereby stimulate the magnocellular nuclei (i.e., the supraoptic and paraventricular nuclei) of the anterior hypothalamus through axons that descend through the pituitary stalk to the posterior lobe of the pituitary gland. The present invention also relates to a method for spatial and temporal electrically interfacing with an organ, preferably brain tissue, more preferably the pituitary gland, the method comprising the steps of: providing an electrode array according to the invention, and electrically contacting at least a portion of the plurality of electrodes with the tissue by conformally contacting a surface of the tissue with the electrode array; and spatio-temporally interfacing the brain tissue with the conformable device to monitor or actuate a spatio-temporal profile over the surface of the brain tissue in electrical contact with the plurality of electrodes; and actuating electrical activity over the brain surface by applying an electric potential of a plurality of individual brain surface locations beneath each electrode of the array of electrodes at a plurality of different locations and/or time points; and/or optionally, monitoring the spatio-temporal electrical brain profile with the device in conformal and electrical contact with a brain surface of a subject, wherein the monitoring comprises detecting an electric potential of a plurality of individual brain surface locations beneath each electrode of the array of electrodes at a plurality of different time points.
• Moreover, electrical activity of a patient's pituitary cells and pituitary functions of a patient can be continuously measured and controlled via an electrode implanted in the pituitary gland and connected to a controller implanted subcutaneously in the patient. Likewise, the pituitary stalk or the hypothalamus could be treated with electrical pulses and/or therapeutic liquids or their functions could be continuously measured and controlled. Moreover, a catheter can be provided having an electrical stimulating device at its distal end which can be used for: i) identification of cranial nerves, particularly the abducens nerve; this can be done by EMG (electrode near or in the eye), or the patient indicating symptoms (diplopia); and ii) identifying the carotid artery, for instance by measuring temperature, oxygenation, flow, pulsations or by echo doppler.
• The present invention also relates to a method of alleviating an endocrinological condition in a patient suffering therefrom, the method comprising the steps of:
• • placing an electrode in electrical contact with the pituitary gland;
  • detecting a bodily activity or a physiological change (e.g., temperature or heart rate) associated with the endocrinological condition; and
  • activating the electrode to initiate application of an electrical signal to the pituitary gland, or adjusting application of an electrical signal to the pituitary gland in response to alleviate the patient's endocrinological disorder.
    In this regard, electrical stimulation of the pituitary gland by the electrode can be used to treat the following indications:

• Pituitary Gland	Treatment	Indication
  Anterior lobe	Decrease ACTH Production	M. Cushing
  Anterior lobe/	Increase ACTH Production	Secondary adrenal
  intermediate		insufficiency
  lobe
  	Increase ACTH Production	Pituitary insufficiency
  	Increase ACTH/alfa MSH	Auto immune disorders
  	Production
  	Modification ACTH	Depression
  	production
  	Decrease PRL Production	Prolactinoma
  	Modification FSH/LH	Poly Cystic Ovary
  	Production	Syndrome
  Posterior lobe	Increase Oxytocin Production	Severe oncological pain
  	Increase Oxytocin	Anxiety disorders and
  	Production	PTSD

• Preferably, the present invention also relates to a method for the intra-pituitary gland administration of a pharmacologically active agent inducing production of steroidal hormones in the adrenal glands of a mammalian patient, the method comprising transferring into/around the pituitary gland a pharmaceutical preparation comprising an effective concentration of the pharmacologically active component through a microcannula as disclosed herein above. Preferably the active agent comprises a corticotropin-releasing hormone (CRH) or analogue thereof, or any other suitable agent including peptides and/or oligonucleotides.
• The present invention also relates to a system and method in which a distal end of an electrode array is implanted, preferably permanently, in an organ, preferably brain tissue, such as a pituitary gland, of a mammalian patient for intermittent electrical stimulation thereof and a proximal end of the electrode is provided with a connection plug, a distal end of which can be attached to a bone adjacent the organ, such an anterior wall of the sphenoid sinus/vomer, and a proximal end of which can be reversibly connected electrically to a wire that is connected electrically to a source of electrical stimulation for the organ.
• Preferably the electrode array is provided for interfacing with the organ tissue in situ, the electrode array comprising: a. a deformable array of electrodes comprising a plurality of electrodes in electrical communication with a plurality of deformable electrical interconnects and a connector line; wherein the deformable array of electrodes provides a net bending stiffness of the array low enough that the device is capable of establishing conformal contact with the tissue in situ; and b. a connection plug provided at the proximal end of the connector line of the electrode array provided with a distal end of which can be attached to a bone adjacent the organ, such an anterior wall of the sphenoid sinus/vomer, and a proximal end of which can be reversibly connected electrically to a wire that is connected electrically to a source of electrical stimulation for the organ.
• Preferably, the method according to the invention comprises the steps of:
• • a. providing an electrode array as set out above, and i. electrically contacting at least a portion of the plurality of electrodes with the tissue by conformally contacting a surface of the tissue with the electrode array; and ii. spatio-temporally interfacing the brain tissue with the conformable device to monitor or actuate a spatio-temporal profile over the surface of the brain tissue in electrical contact with the plurality of electrodes; and iii. actuating electrical activity over the brain surface by applying an electric potential of a plurality of individual brain surface locations beneath each electrode of the array of electrodes at a plurality of different locations and/or time points; and iv. optionally monitoring the spatio-temporal electrical brain profile with the device in conformal and electrical contact with a brain surface of a subject, wherein the monitoring comprises detecting an electric potential of a plurality of individual brain surface locations beneath each electrode of the array of electrodes at a plurality of different time points.
• Preferably, the stimulation and/or monitoring comprises treating and/or monitoring a patient suffering from an endocrinological medical condition. More preperably, the endocrinological medical condition comprises a problem related to the components of the endocrine system, such as the adrenal glands, pituitary gland, and hypothalamus, including hypoglycemia, diabetes type I and II, obesity, hyperthyroidism, hypothyroidism, amenorrhea, dysmenorrhea, infertility, impotence, anorgasmia, delayed orgasm, perimenstrual syndrome, hypercholesterolemia, hypertriglycridinemia, Cushing's disease, Addison's disease, Addison's crisis, malabsorption syndrome, dysautonomia, epilepsy, chronic fatigue syndrome, fatigue, heat exhaustion, cold extremities, hot flashes, vasomotor instability, Raynaud's syndrome, hormonal disorders, metabolic disorders such as gout, disorders of metabolism and metabolic storage diseases where there is an accumulation of abnormal amounts of various substances such as glycogen in glycogen storage diseases, iron in hemochromatosis or copper in Wilson's disease, auto-immune disorders, sleep disorders and disruptions in the circadian rhythm. In particular the present invention relates to the treatment of Adison's disease and Adison's crisis, as well as pain, pain perception, post-traumatic stress disorder, depression and anxiety.

Claims (21)

What is claimed herein is:

1. A system for providing electrical pulses and/or therapeutic or diagnostic liquids directly to a pituitary gland of a mammalian patient or to a pituitary stalk, a hypothalamus, or other brain area of a mammalian patient via the pituitary gland;

the system being movable through a catheter having a distal end comprising an opening, the catheter configured to be movable distally through blood vessels of an endovascular route of the mammalian patient and then into and through a sinus cavernosus of the mammalian patient, the system comprising:

a (micro)electrode and/or a microcannula, a distal end of which is configured to be movable distally within the catheter through the endovascular route, and then into and through the sinus cavernosus, and then distally out of the catheter through an opening in the distal end of the catheter, and then through a perforation in a medial wall of the sinus cavernosus to the pituitary gland, and then to and into or around the pituitary gland;

wherein the system is capable of actively bending to a predetermined angle of from 30° to 120° when moving along the endovascular route in the catheter.

2. The system of toclaim 1, wherein the catheter is provided for, and operable to move via the endovascular route from the ileac vein or femoral vein in a groin or the cephalic vein in the arm of the patient wherein the system further comprises at least two action members and/or steering members disposed in an exterior lumen, to actively bend or pivot the catheter to a predetermined angle of no less than 75°.

3. The system of toclaim 1, wherein the catheter further comprises:

at least a first annular wall component;

at least a second annular wall component; and

at least one of:

a) an annular lumen disposed between the first annular wall component and the second annular wall component; and

b) one or more working channels incorporated into the first annular wall component and/or second annular wall component of the catheter, and at least an interior lumen disposed inside the interior of the first annular wall component and/or second annular wall component.

4. The system ofclaim 3, further comprising at least a secondary catheter for accessing the pituitary stalk, the secondary catheter being:

located inside the primary catheter;

provided to be operable to project distally from the first catheter; and

provided and operable for actively bending or pivoting at a predetermined angle of no less than 75°.

5. The system ofclaim 3, wherein the first annular wall component and/or second annular wall component comprises at least one action member and/or steering member.

6. The system according toclaim 1, wherein at least one of the action members is a push wire having a distal end that is disposed to and operable to move:

distally within the catheter, through the endovascular route and then into and through the sinus cavernosus; and

then distally out of the catheter through the opening in the distal end of the catheter and then through the perforation in the medial wall of the sinus cavernosus.

7. The system ofclaim 1, wherein the catheter further comprises a tip containing a sharp element that can be projected distally from the opening in the distal end of the catheter to form the perforation in the medial wall of the cavernous sinus.

8. The system ofclaim 1, wherein a distal-most part of the catheter further comprises a malleable cushion to allow good contact of the distal-most part with the surface of the medial wall of the sinus cavernosus;

wherein the exterior of the distal end of the catheter, adjacent to, and proximal of, the malleable cushion, comprises an annular collar that can be inflated or otherwise deployed, so that distal surfaces of the annular collar are projected distally from the distal end of the catheter, enclosing a volume around the distal end of the catheter, around the perforation in the medial wall of the cavernous sinus to close a space around the opening in the distal end of the catheter between the distal end of the catheter and the perforation.

9. The system ofclaim 2, wherein the action member comprises at least a first guide wire for pivoting or steering the distal end of the catheter in a desired direction, for controlling its distal movement through the endovascular route and then into and through the sinus cavernosus.

10. The system ofclaim 1, wherein an exterior of a distal part of the catheter and/or the microcannula, comprises a radiopaque ring that can be recognized by X-ray, fluoroscopy, angiogram, MRI, or a CT-scan; and/or

wherein a distal part of the catheter comprises an electromagnetic localizer which comprises a transmitter and receiver coil array, permitting it to transmit electromagnetic signals and receive electromagnetic energy from a transmitter coil array.

11. The system ofclaim 8, wherein an exterior of the distal end of the catheter, adjacent to, and proximal of, the annular collar, also comprises a stabilizing device comprising an inflatable tripod and provided circumferentially about an exterior of the catheter and comprising inflatable, radially extendable legs.

12. The system ofclaim 1, wherein a distal part of the catheter has a peel-away configuration, so that the catheter can be removed from the patient in such a way that the electrode or microcannula remains intact and in place.

13. The system ofclaim 1, wherein the system further comprises an electrode or electrode array, the distal end of which has one or more contact points for electrical stimulation of endocrine tissue of the pituitary gland, the pituitary stalk, or the hypothalamus; and/or

the system comprises a microcannula, the distal end of which has one or more central hollow channels, each central hollow channel comprising one or more side openings, through which small volumes of a fluid or gel can flow into the pituitary gland, the pituitary stalk, or the hypothalamus, preferably with side openings that can be opened and closed by a remote control.

14. The system ofclaim 13, wherein the distal end of the electrode is adapted to:

electrically stimulate the pituitary gland to produce and secrete adrenocorticotropic hormone (ACTH) and/or alpha-melanocyte stimulating hormone (MSH); and/or

electrically stimulate the pituitary gland to stimulate the magnocellular nuclei of the anterior hypothalamus through axons that descend through the pituitary stalk to the pituitary gland.

15. The system ofclaim 13, wherein a distal portion of the electrode or electrode array and/or microcannula has a shape memory and thus can form a three-dimensional shape, within or about the pituitary gland.

16. The system ofclaim 15, wherein the electrode array is provided for interfacing with an organ tissue in situ, the electrode array comprising:

a) a deformable array of electrodes comprising a plurality of electrodes in electrical communication with a plurality of deformable electrical interconnects and a connector line; wherein the deformable array of electrodes provides a net bending stiffness of the electrode array low enough that the system is capable of establishing conformal contact with the tissue in situ; and

b) a connection plug at a proximal end of the connector line of the electrode array, the connection plug comprising:

a distal end which can be attached to a bone adjacent to the organ tissue, including but not limited to an anterior wall of the sphenoid sinus and/or vomer, and

a proximal end which can be reversibly connected electrically to a wire that is connected electrically to a source of electrical stimulation for the organ tissue.

17. The system ofclaim 3, wherein the first annular wall component and/or second annular wall component is removable while leaving the microcannula and/or the electrode or electrode array in place, and optionally, further comprising an optionally subcutaneously provided reservoir and/or control or pump unit for controlling and providing electrical pulses and/or therapeutic or diagnostic liquids directly to a pituitary gland via the microcannula or electrode, and/or measuring of currents in the electrode or electrode array.

18. A method for providing electrical pulses and/or therapeutic or diagnostic liquids directly to a pituitary gland of a mammalian patient or to a pituitary stalk or to a hypothalamus or other basal ganglia of the brain of the mammalian patient via the pituitary gland, comprising the steps of:

moving the distal end of a catheter of a system according toclaim 1 through an endovascular route of the mammalian patient from a vena jugularis of the mammalian patient, to an inferior or superior petrosal sinus of the mammalian patient, and then to a sinus cavernosus of the mammalian patient;

perforating a medial wall of the cavernous sinus to the pituitary gland;

moving the distal end of the electrode or microcannula or both distally from the catheter, through the opening in the distal end of the catheter and through the perforated medial wall of the sinus cavernosus, to the pituitary gland; and

removing the annular wall section of the catheter after leaving the electrode and/or microcannula in place.

19. A method of alleviating an endocrinological medical condition in a mammalian patient suffering therefrom, the method comprising the steps of:

(i) placing an electrode or electrode array in electrical contact with the pituitary gland of the mammalian patient using a system according toclaim 1;

(ii) detecting an activity associated with, or of relevance to, the endocrinological medical condition; and

(iii) activating the electrode or electrode array to initiate application of an electrical signal to the pituitary gland, or adjusting application of an electrical signal to the pituitary gland to alleviate, repair, or prevent worsening of the patient's endocrinological medical condition;

wherein the endocrinological medical condition comprises a problem related to the components of the endocrine system, including but not limited to the adrenal glands, pituitary gland, and hypothalamus, including hypoglycemia, diabetes type I and II, obesity, hyperthyroidism, hypothyroidism, amenorrhea, dysmenorrhea, infertility, impotence, anorgasmia, delayed orgasm, perimenstrual syndrome, hypercholesterolemia, hypertriglycridinemia, Cushing's disease, Addison's disease, Addison's crisis, malabsorption syndrome, dysautonomia, epilepsy, chronic fatigue syndrome, fatigue, heat exhaustion, cold extremities, hot flashes, vasomotor instability, Raynaud's syndrome, hormonal disorders, metabolic disorders such as gout, disorders of metabolism and metabolic storage diseases where there is an accumulation of abnormal amounts of various substances such as glycogen in glycogen storage diseases, iron in hemochromatosis or copper in Wilson's disease, auto-immune disorders, sleep disorders and disruptions in the circadian rhythm. In particular the present invention relates to the treatment of Adison's disease and Adison's crisis, as well as pain, pain perception, post-traumatic stress disorder, depression and anxiety.

20. A method for the intra-pituitary gland administration of a pharmacologically active agent inducing or inhibiting production of steroidal hormones in the adrenal glands of a mammalian patient through change of the pituitary gland function, including but not limited to wherein the active agent comprises a corticotropin-releasing hormone (CRH) or analogue thereof, or combinations of CRH with other pharmacologically active components like vasopressin, the method comprising:

i)a) transferring into the pituitary gland a pharmaceutical preparation comprising an effective concentration of the pharmacologically active agent through the microcannula of the catheter of the system according toclaim 1; and/or

i)b) electrically contacting at least a portion of the plurality of electrodes with the tissue by conformally contacting a surface of the tissue with the electrode array of a system according toclaim 1;

ii) spatially and temporally interfacing a brain tissue with the conformable device to monitor or actuate a spatio-temporal profile over the surface of the brain tissue in electrical contact with the plurality of electrodes; and

iii) actuating electrical activity over the surface of the brain tissue by applying an electric potential to a plurality of individual brain surface locations, each beneath an electrode of the plurality of electrodes at a plurality of different locations and/or time points.

21. The method ofclaim 20, further comprising monitoring the spatio-temporal electrical brain profile with the device in conformal and electrical contact with a brain surface of the subject, wherein the monitoring comprises detecting an electric potential of a plurality of individual brain surface locations beneath each electrode of the array of electrodes at a plurality of different time points.

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