US20140248314A1 - Pre-fusion rsv f antigens - Google Patents

Abstract

The invention relates to pre-fusion RSV F protein and polypeptides that contain one or more amino acid mutations that stabilize the pre-fusion conformation or destabilize the post-fusion conformation. The invention also relates to methods for inducing an immune response to pre-fusion RSV F.

Description

RELATED APPLICATION
• This application claims priority to U.S. Provisional Application 61/486,005 filed on May 13, 2011. The entire contents of the foregoing application is incorporated herein by reference.
SEQUENCE LISTING
• The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on May 11, 2012, is named PAT05457.txt and is 98,385 bytes in size.
BACKGROUND OF THE INVENTION
• Respiratory syncytial virus (RSV) is an enveloped non-segmented negative-strand RNA virus in the family Paramyxoviridae, genusPneumovirus. It is the most common cause of bronchiolitis and pneumonia among children in their first year of life. RSV also causes repeated infections including severe lower respiratory tract disease, which may occur at any age, especially among the elderly or those with compromised cardiac, pulmonary, or immune systems.
• To infect a host cell, paramyxoviruses such as RSV, like other enveloped viruses such as influenza virus and HIV, require fusion of the viral membrane with a host cell's membrane. For RSV the conserved fusion protein (RSV F) fuses the viral and cellular membranes by coupling irreversible protein refolding with juxtaposition of the membranes. In current models, based on paramyxovirus studies, the RSV F protein initially folds into a “pre-fusion” conformation. During cell entry, the pre-fusion conformation undergoes refolding and conformational changes to its “post-fusion” conformation.
• The RSV F protein is translated from mRNA into an approximately 574 amino acid protein designated F₀. Post-translational processing of F₀includes removal of an N-terminal signal peptide by a signal peptidase in the endoplasmic reticulum. F₀is also cleaved at two sites (109/110 and 136/137) by cellular proteases (in particular furin) in the trans-Golgi. This cleavage results in the removal of a short intervening sequence and generates two subunits designated F₁(˜50 kDa; C-terminal; approximately residues 137-574) and F₂(˜20 kDa; N-terminal; approximately residues 1-109) that remain associated with each other. F₁contains a hydrophobic fusion peptide at its N-terminus and also two amphipathic heptad-repeat regions (HRA and HRB). HRA is near the fusion peptide and HRB is near the transmembrane domain. Three F₁-F₂heterodimers are assembled as homotrimers of F₁-F₂on the surface of the virion.
• A vaccine against RSV infection is not currently available, but is desired. Vaccine candidates based on the chief RSV neutralization antigen, the F glycoprotein, have foundered due to problems with stability, purity, reproducibility, and potency. Crystal structures of related parainfluenza F glycoproteins have revealed a large conformational change between the pre-fusion and post-fusion states. The magnitude of the rearrangement suggested that post-fusion F antigens would not efficiently elicit neutralizing antibodies, which presumably must bind epitopes exposed on the pre-fusion conformation. Accordingly, efforts to produce a vaccine against RSV have focused on developing subunit vaccines that contain pre-fusion forms of RSV F. (See, e.g., WO 2010/149745, WO 2010/149743, WO 2009/079796) This focus on pre-fusion forms of RSV F has been corroborated by available models of RSV F.
• Pre-fusion F is a “metastable” structure that readily rearranges into the lower energy post-fusion state, which then aggregates due to exposure of a hydrophobic fusion peptide (Begona Ruiz-Arguello, M. et al.Virology298, 317-326 (2002) (142)). Large structural differences between the lollipop-shaped pre-fusion F trimer and the crutch-shaped post-fusion F trimer are apparent even at the resolution of electron microscopy of negatively stained specimens, suggesting that pre-fusion and post-fusion F may be antigenically distinct (Calder, L. J. et al.Virology271, 122-131 (2000) (143)). To prevent viral entry, F-specific neutralizing antibodies presumably must bind the pre-fusion conformation of F on the virion, before the viral envelope fuses with a cellular membrane. However, efforts to generate a soluble, stabilized pre-fusion F subunit antigen have not yet yielded candidates suitable for testing in humans. Furthermore, analysis of a Motavizumab-peptide complex and homology modeling suggested that the dominant neutralizing epitope recognized by Palivizumab and Motavizumab might be buried in trimeric F, requiring at least a local dissociation for surface exposure to allow antibody binding (McLellan, J. S. et al.Nat Struct Mol Biol17, 248-250 (2010)). There is a need for improved RSV F protein compositions and methods for making RSV F protein compositions.
SUMMARY OF THE INVENTION
• The invention relates to pre-fusion respiratory syncytial virus (RSV) F polypeptides and pre-fusion chimeric F polypeptides.
• In some aspects, the pre-fusion respiratory syncytial virus (RSV) F polypeptide comprises at least two introduced cysteine residues that are in close proximity to one another, and form a disulfide bond that stabilizes the pre-fusion RSV F polypeptide. In particular embodiments, the HRB region contains an introduced cysteine residue and the DI and/or DII region contain an introduced cysteine residue, and a disulfide bond is formed between the introduced cysteine residue in the HRB region and the introduced cysteine residue in the D1 or DII region. In other embodiments, the HRA region contains an introduced cysteine residue and the DIII region contains an introduced cysteine residue, and a disulfide bond is formed between the introduced cysteine residue in the HRA region and the introduced cysteine residue in the III region. In other embodiments, the HRA region contains at least 2 introduced cysteine residues, and a disulfide bond is formed between the introduced cysteine residues in the HRA region.
• In other aspects, the pre-fusion respiratory syncytial virus (RSV) F polypeptide comprises a post-fusion modification selected from the group consisting of deletion of the HRA helix, deletion of the HRB helix, introduction of point mutations, addition of glycosylation sites and combinations thereof, wherein said post-fusion modification destabilizes the post-fusion conformation. In some embodiments, the destabilizing post-fusion modification is deletion of the HRB helix, in whole or in part. If desired, the destabilizing post-fusion modification can further comprise deletion of the fusion peptide, in whole or in part. In other embodiments, the destabilizing post-fusion modification includes addition of a glycosylation site, such as glycosylation on a residue selected from the group consisting ofposition 173, position 175 and position 184.
• In another aspect, the invention is a pre-fusion respiratory syncytial virus (RSV) F protein comprising three RSV F monomers, wherein at least two of the monomers contain an introduced cysteine residue, the introduced cysteine residues are in close proximity to one another and form a disulfide bond that stabilizes the pre-fusion RSV F protein.
• In another aspect, the invention is a chimeric pre-fusion F protein comprising a stabilized F protein from a virus other than RSV, such as parainfluenza virus F polypeptide or a metapneumovirus virus F polypeptide, that contains one or more neutralizing epitope of RSV F. Suitable neutralizing epitopes can be selected from the group consisting of the epitopes that are recognized by motavizumab, palivizumab,mAb 11, mAb 151, mAb 1129, mAb 1153, mAb 1200, mAb 1214, mAb 1237, mAb 47F, mAb 7C2, mAb B4,Fab 19, mAb AK13A2, mAb 7.936, mAb 9.936,mAb 19,mAb 20,mAb 101F and combinations thereof.
• The invention relates to methods for inducing an anti-respiratory syncytial virus (RSV) immune response in a subject, comprising administering to the subject an effective amount of an immunogenic composition comprising a pre-fusion RSV F protein or a pre-fusion chimeric F protein. Preferably, the induced immune response is characterized by neutralizing antibodies to RSV and/or protective immunity against RSV.
• In particular aspects, the invention relates to a method for inducing or raising neutralizing anti-respiratory syncytial virus (RSV) F protein antibodies in a subject, comprising administering to the subject an effective amount of an immunogenic composition comprising a pre-fusion RSV F protein or a pre-fusion chimeric F protein.
• In particular aspects, the invention relates to a method for inducing or raising protective immunity against respiratory syncytial virus (RSV) in a subject, comprising administering to the subject an effective amount of an immunogenic composition comprising a pre-fusion RSV F protein or a pre-fusion chimeric F protein.
• In particular aspects, the invention relates to immunogenic compositions comprising a pre-fusion respiratory syncytial virus (RSV) F protein or a pre-fusion chimeric F protein.
• The pre-fusion RSV F protein that is used in the invention can be full length or truncated, such as a soluble ectodomain that lacks the cytoplasmic and transmembrane domains. The pre-fusion RSV F protein, e.g., full length or soluble ectodomain, may comprise functional furin cleavage sites atpositions 109/110 and 136/137. In some preferred embodiments, that pre-fusion RSV F protein (e.g., full length or soluble ecto-domain) contains the amino acid sequence of the corresponding portion (e.g., ecto-domain) of a naturally occurring RSV F protein. In any of the aspects of the invention, the pre-fusion RSV F protein can be administered with or without an adjuvant as desired, and the immunogenic composition can comprise an adjuvant if desired.
BRIEF DESCRIPTION OF THE DRAWINGS
• FIG. 1 shows a structure-based sequence alignment of four F proteins, secondary assignment, and key features. The alignment of RSV (SEQ ID NO:33), Newcastle disease virus (NDV) (SEQ ID NO:34), PIV3 (SEQ ID NO:36) and PIV5 (SEQ ID NO:35) Fs was generated with ClustalW2 (http://www.ebi.ac.uk/Tools/msa/clustalw2/), adjusted manually based on structural superposition using Lsqkab from the CCP4 suite of programs and displayed using ESPript version 2.2 (http://espript.ibcp.fr/ESPript/ESPript/). Features of RSV F are indicated above the sequences; features of PIV3 F are indicated below the sequences. *CHO indicates RSV F glycosylation sites. Secondary structure elements are indicated, with arrows parallel to the sequences designating β-sheets, cylinders designating α-helices, “TT” designating turns, and coils designating 3₁₀helices. The domain location of secondary structure symbols are indicated (DI, DII, DIII), except for RSV helices α5 and α6, which are labeled to indicate that they form the Motavizumab binding site and P20 and P21, which are labeled to indicate that they form the 101F binding site. Circled numbers (RSV) or triangled numbers (PIV3) designate residues that form disulfide bonds, with the same number for each partner in a disulfide-linked pair. The furin cleavage sites for RSV F and PIV3 F are indicated by vertical arrows labeled Fr. The RSV F p27 region released from the protein after furin cleavage is indicated by a black bar. The fusion peptides of RSV F and PIV3 F are labeled. The arrow in the fusion peptide indicates the first residue of the F1 fragment in the fusion peptide deletion construct used in this study. Residues that are identical in all four proteins are indicated by shaded boxes. Peptides used to investigate neutralizing binding sites are in open boxes and resistance mutations are indicated by asterisks.
• FIG. 2 shows electron microscopy and circular dichroism analysis of the RSV F post-fusion trimer. InFIG. 2A an electron micrograph of the RSV F protein shows a field of uniform crutch phenotypes consistent with the structure of post-fusion F proteins.FIG. 2B shows a CD melting curve of the post-fusion RSV F trimer observed at 210 nm, the observed spectral minimum of the folded RSV F protein. The CD absorption, y-axis, is plotted against temperature, x-axis.FIG. 2C shows a CD spectra of the post-fusion RSV F trimer at 20° and 95° C. The spectra were recorded from 320 to 190 nm and show at both temperatures characteristic helical minima for a folded protein.
• FIG. 3 shows representative electron densities of the crystallized RSV F protein.FIG. 3A is a side view of the original molecular replacement solution model, which contains the PIV3 post-fusion head in-frame with the 6-helix bundle of RSV F, shown in the initial electron density map (1σ) calculated after iterative real-space NCS three-fold averaging, histogram matching, and solvent flattening with phase extension from 7.0 to 3.2 Å and no phase recombination. The head region fits poorly in the electron density.FIG. 3B Side view. The final model of RSV F shown in the averaged electron density map as described inFIG. 4A.FIG. 3C shows a top view of the RSV F protein structure shown inFIG. 4A.FIG. 3D shows a top view of B. Model and electron density depicted as inFIG. 4B.FIG. 3E is a close up of a representative averaged electron density (gray) with the final model in stick representation.FIG. 3F shows the same view as inFIG. 4E but with final 2mFo-dFc electron density map contoured at 1.5σ.
• FIG. 4 shows the RSV F ectodomain structure.4A is a linear diagram. Listed residue numbers correspond to the N-terminus of each segment, the furin cleavage sites (arrow heads), and the C-terminus DI-III, domains I-III; p27, excised peptide; FP, fusion peptide; HRA, B, and C, heptad repeats A, B, and C.4B shows a ribbon representation of one subunit of the RSV F ectodomain trimer. Domains are labeled and shaded as in4A, glycans are shown in black. 4C shows surface representation of the RSV F ectodomain trimer. The domains of one subunit are labeled and shaded as in4A, the other two subunits are white and gray.
• FIG. 5 shows superposition of domains I and II of RSV F and PIV3 F.FIG. 5A shows a ribbon diagram of domain I from RSV and PIV3 superimposed by matching the common β-sheets.FIG. 5B shows a ribbon diagram of domain II from RSV F and PIV3 F superimposed based on common β-strands. The secondary structure elements of RSV F are labeled.
• FIG. 6 illustrates a comparison between RSV and PIV3.FIG. 6A is a ribbon diagram of RSV F domain III.FIG. 6B shows a ribbon diagram of the PIV3 domain III oriented to match orientation shown inFIG. 6A.FIG. 6C shows the detail of the RSV and PIV3 (which are shaded differently) domain III helical bundles superimposed based on domain III β-sheets.FIG. 6D shows RSV and PIV3 F ectodomain trimers (shaded as in A and B) superimposed based on their six-helix bundles. The image on the left shows a ribbon diagram viewed perpendicular to the three-fold axis; the image on the right is a surface representation viewed along the three-fold axis from the top of the head.
• FIG. 7 illustrates the Motavizumab epitope.FIG. 7A is a superposition of the Motavizumab-binding helices, α5 and α6, from the RSV F post-fusion trimer and the peptide-Motavizumab complex (PDB code 3IXT). The post fusion trimer structure and the peptide-motavizumab complex structure are shaded differently. RSV residues bound by Motavizumab are shown in stick representation. Asterisks denote Palivizumab escape mutations.FIG. 7B shows a ribbon representation modeling a Motavizumab-RSV F post-fusion trimer complex. The V_Hand V_Ldomains of the Fab are labeled; helices α5 and α6 from the RSV F structure and the peptide-Motavizumab structure are shaded differently; a glycan on RSV F is black; and the remainder of RSV F is white.
• FIG. 8 illustrates RSV F conformational changes, antigenic structure and Palivizumab binding.FIG. 8A is a surface representation of the post-fusion structure. Antigenic sites A and C are outlined and labeled. Asterisks indicate residues selected in neutralization escape variants or forming contacts with an antibody in the determined structures of neutralizing antibody-peptide complexes. The HRA and HRB surfaces are shaded.FIG. 8B is a surface representation of a pre-fusion model, annotated as in A.FIG. 8C is a graph showing inhibition of Palivizumab binding to post-fusion RSV F by pooled sera from un-immunized mice or mice immunized with the RSV F antigen. Palivizumab binding (percentage of ELISA signal without competing sera) is plotted as a function of the dilution of competing pooled sera.
• FIG. 9 shows the exposure of the Motaviuzumab epitope in the post-fusion RSV F structure (A) and pre-fusion RSV F model (B).FIG. 9A shows Domain III of one subunit from the post-fusion structure shaded black and grey while the remaining parts of RSV F are in white. Structural elements that do not significantly change betweeen pre- and post-fusion are in black while HRA (labeled with arrow), which refolds in the transition from the pre- to post-fusion conformation, is lighter grey. Motavizumab epitopes on two subunits are also labeled. A third Motavizumab epitope is present on the trimer surface, but is not easily visible in this orientation. The Motavizumab epitope α5 and α6 helices are labeled on one example.FIG. 9B shows Domain III of the pre-fusion model shaded as in A. The fusion peptide region is shaded and labeled FP. The HRA region is broken into structural elements α1, α2, α3, β1 and β2; labeled and shaded grey for one subunit. In both the pre-fusion and post-fusion structures, the α5 and α6 helices of the Motavizumab epitope are surface exposed. However, in the pre-fusion model, the HRC loop may need to shift to accommodate antibody binding (as indicated by the arrow).
• FIG. 10 shows a model of neutralizingantibody 101F bound to the post-fusion RSV F trimer.FIG. 10A shows the peptide (residues 431-435) (SEQ ID NO:37) from the 101F Fab-peptide complex structure (PDB code 3O41²¹) superposed on equivalent residues of the RSV F structure (β-strand 20 to β-strand 21).FIG. 10B is a ribbon representation of a model of the 101F Fab bound to the RSV F post-fusion trimer. 101F Fab V_Hand V_Ldomains are labeled; RSV F β-strand 20 and β-strand 21 and labeled as in A. The remaining parts of RSV F are in white.FIG. 10B discloses “IIKTF” as SEQ ID NO: 37.
• FIGS. 11A-C show that residues within appropriate distances to form disulfides can be identified, based on the current model of RSV F pre-fusion, can be identified.FIG. 11A (Center), The pre-fusion RSV F model is shaded/colored to show structural features which are labeled (HRB, HRA, DIII).FIG. 11B (Left) is a zoom-in view of the packing of HRA on domain III in the pre-fusion model. The paired numbers indicate residues in close proximity which, if mutated to cysteines could form a disulfide bond.FIG. 11C (Right) is a zoom-in view of the packing of the HRB-stalk on domains I and III (white). The paired numbers indicate residues which, if mutated to cysteines could form a disulfide bond Amino acid residues 165 and 296, and 56 and 164 are not at ideal distances to one another, in the pre-fusion model, to form disulfide bonds, but are in correct orientation and can form disulfides if the model is biased by the PIV5 structure, on which the model was built.
• FIG. 12 shows a negative stained electron micrograph of the HRB-deleted RSV F construct (RSV F delHRB HIS, SEQ ID NO:28). Electron microscopy of the HRB-deleted RSV F construct demonstrated the RSV F protein formed rosettes, likely through the fusion peptide. The formation of rosettes through the fusion peptide is a feature of post-fusion RSV F rather than a predicted behavior of pre-fusion F proteins (Ruiz-Arguello et al. 2004 (142) and Connolly et al, 2006 (144)). This result shows the HRB-deleted RSV F construct does not appreciably stabilize the protein in the desired pre-fusion conformation.
• FIG. 13 shows the structure of RSV F protein in which certain mutations are introduced to inhibit 6-helix bundle formation. Shown is the RSV F post-fusion structure in which the HRB helix has been removed and replaced with a hypothetical random coil (represented by the lines). The elongated HRA helix of the post-fusion RSV F is labeled. The numbers represent potential sites for introduced glycosylation sites or other mutations which interfere with formation of the 6-helix bundle characteristic of the post-fusion structure. A mutation on the HRA helix which interferes with HRB interaction would destabilize the post-fusion conformation, which in turn would cause the protein to remain in the favored pre-fusion conformation.
• FIGS. 14 A and B are western blots of cell lysates (14A, showing total expression) or media (14B, showing secreted protein) under boiled and reducing conditions using an anti-His tag antibody. The westerns show the expression of RSV-F proteins, and that proteins with engineered cysteine residues were expressed and contained intra-chain disulfide bonds. Cleavage of RSV F protein from F0 to F1/F2 and secretion from the cell is evidence of proper protein folding of the RSV F proteins. Migrations for uncleaved F0 and cleaved F1 are indicated. The key for gel lane labeling is shown above the blots. (A) Western blot of cell lysate indicating total protein expression. Each protein construct was well expressed by the cell. (B) Western blot of RSV F secreted into the media. The secreted protein was predominantly cleaved (F1) and the amount of secretion varied among proteins. The results of this analysis indicate that the T58C & V164C, K₁₆₈C & V296C and M396C & F483C protein constructs were the best expressed/secreted protein constructs. R049: RSV-F fus del R429S1432T K₄₃₃T S436F trunc (SEQ ID NO:39); R050: RSV-F HRA Disulfide-2 I57C 5190C trun (SEQ ID NO:40); R051: RSV-F HRA Disulfide-3 T58C V164C trunc (SEQ ID NO:6); R052: RSV-F HRA Disulfide-5 K168C V296C trunc (SEQ ID NO:8); R053: RSV-F fus del N262Y N268I K₂₇₂M R429S1432T K433T S436F trunc (SEQ ID NO:41); R054 RSV-F HRA Disulfidel V56C V164C trunc (SEQ ID NO:4); R055RSV-F HRA Disulfide-4 N165C V296C trunc (SEQ ID NO: 7); R056RSV-F HRB Disulfide M396C F483C trunc (SEQ ID NO:9).
• FIGS. 15 A-C show SEC analysis of RSV F intra-chain disulfide. Postfusion F rosettes and fusion peptide deleted RSV F trimers were used to develop an HPLC-SEC assay to differentiate between rosettes and trimers. (FIG. 15 A) Fusion peptide-stabilized RSV F rosettes migrated with the void volume by SEC (retention time of 5 minutes on Bio-Sil 250 SEC column). Anti-HIS-tag western blotting confirmed that the protein was in the void volume peak. (FIG. 15 B) Fusion peptide-deletion RSV F trimers migrated with an SEC retention time of approximately 6.5 minutes. Anti-HIS-tag western blot similarly confirmed that the protein was in the included volume trimer peak. Although the void peak is larger than the included volume peak, the anti-HIS western shows approximately equal amounts of RSV F are in the two peaks. (FIG. 15 C) These data show that the RSV F T58C V164C construct had a population of cleaved RSV F that was in the form of monodispersed trimers rather than rosettes, suggesting that population of the protein construct was in the prefusion form.
• FIGS. 16 A-C show purification and analysis of RSV F protein constructs that contain engineered cysteins.FIG. 16 A shows purification of the RSV F N165C/V296C construct. Columns are labeled for flow-through (FT), wash (W), elution (E) and resin (R) from a chelating purification. Unlike other protein constructs that contained introduced disulfide mutations and were expressed in insect cells, N165C/V296C secreted as a cleaved species, similar to its profile when expressed in mammalian cells.FIG. 16 B shows a gel-shift analysis of the K168C/V296C and M396C/F483C RSV F protein constructs. On the left side of the standards are the two constructs run with boiling and reducing agent present. On the right side of the standards, the two constructs are run after boiling with no reducing agent (b/nr) or no boiling and no reducing agent (nb/nr). The western blot shows the protein is largely uncleaved, but that unexpectedly no inter-chain disulfide bonds were formed. K168C/V296C without boiling shifted to the trimer band, while non-boiled M396C/F483C ran as a monomer band.FIG. 16 C shows a coomasie-stained gel of the K168C/V296C and M396C/F483C RSV F protein constructs with reducing and boiling. Approximately 50% of the material was cleaved.
• FIG. 17(A) shows electron microscopy analysis of NDV F (prefusion) with the expected spherical heads for prefusion F, with a few rosette-like aggregates.FIG. 17(B) shows NDV prefusion F forms rod-like crystals. An isolated rod was analyzed and a dataset with ˜95% completion to ˜3.7 angstroms was recorded.FIG. 17 (C) shows NDV prefusion F forms bipiramidal crystals (50×50×50 μm size).
• FIGS. 18 A-E show analysis of several RSV F protein constructs.FIG. 18A shows EM analysis of RSV F Del-HRB showing that 100% formed rosettes. The protein eluted from the SEC column in the void/rosette retention peak.FIG. 18(B) shows analysis/purification of the Del-HRB Del-FP RSV F construct. The protein was found in both the void and trimer retention peaks.FIG. 18C shows gel-analysis, which suggests that there was partially cleaved RSV F Del-HRB Del-FP present in both the void and trimer peaks.FIG. 18D shows EM of NDV F (prefusion), which shows the expected spherical heads for pre-fusion F with a few rosette-like aggregates.FIG. 18E shows that RSV F Del-HRB from the SEC trimer peak contains a heterogeneous mix of rosette-like structures, post-fusion crutches and pre-fusion head-like spherical species.
• FIG. 19 shows SDS-PAGE analysis of chimeric RSV F/NDV and RSV F/PIV5 F protein constructs. The supernatant from cells transfected with one of the six constructs (1: RSV-F NDV HRB del fus trunc; 2: RSV-F NDV HRB trunc; 3: RSV-F NDV HRB2 del fus trunc; 4: RSV-F NDV HRB2 trunc; 5: RSV-F PIV5 HRB del fus trunc; 6: RSV-F PIV5 HRB trunc) was analyzed by SDS-PAGE. The constructs were engineered with or without (del fus) fusion peptide. The proteins either had an NDV HRB, an NDV HRB with an additional glycine residue as a linker (HRB2) or PIV5 HRB as indicated. For each construct, a cleaved F1 protein was observed consistent with a processed F protein. One liter expressions of each protein was performed.
DETAILED DESCRIPTION OF THE INVENTIONDefinitions
• As used herein, “pre-fusion” RSV F proteins are RSV F proteins that share general structural architecture more similar to the PIV5 pre-fusion structure rather than the RSV F post-fusion structure. Pre-fusion RSV F proteins include the following characteristics: the HRA region is packed against domain III in the RSV F head region and/or the HRB region forms a trimer coil-coil stalk in proximity to domains I and II rather than associating with the HRA region in the context of the 6-helix bundle.
• As used herein, “post-fusion conformation” of RSV F protein are RSV F proteins that share more general structural architecture with the RSV F post-fusion structure rather than the PIV5 pre-fusion structure. Post-fusion RSV F proteins include an HRA-HRB 6-helix bundle.
• As used herein, HRA region in prefusion RSV F is approximately residues 137-239 of RSV F protein (SEQ ID NOS: 1 and 2) and comprises the fusion peptide, helix α1, helix α2, helix α3, helix α4, strand β1 and strand β2. See,FIG. 9B.
• As used herein, the HRA helix in post fusion RSV F is formed by approximately residues 155-226 of RSV F protein (SEQ ID NOS: 1 and 2).
• As used herein, the fusion peptide is defined by residues 137-154 of RSV F protein (SEQ ID NOS: 1 and 2).
• As used herein, helix α1 in the prefusion RSV F HRA region is formed by approximately residues 145-157 of RSV F protein (SEQ ID NOS: 1 and 2).
• As used herein, helix α2 in the prefusion RSV F HRA region is formed by approximately residues 158-167 of RSV F protein (SEQ ID NOS: 1 and 2).
• As used herein, helix α3 in the prefusion RSV F HRA region is formed by approximately residues 168-176 of RSV F protein (SEQ ID NOS: 1 and 2).
• As used herein, helix α4 in the prefusion RSV F HRA region is formed by approximately residues 194-212 of RSV F protein (SEQ ID NOS: 1 and 2).
• As used herein, strand 131 in the prefusion RSV F HRA region is formed by approximately residues 177-184 of RSV F protein (SEQ ID NOS: 1 and 2).
• As used herein, strand 132 in the prefusion RSV F HRA region is formed by approximately residues 185-193 of RSV F protein (SEQ ID NOS: 1 and 2).
• As used herein, HRB region in RSV F is approximately residues 461-515 of RSV F protein (SEQ ID NOS: 1 and 2) and includes the HRB helix and the HRB linker
• As used herein, the HRB helix in RSV F is formed by approximately residues 485-515 of RSV F protein (SEQ ID NOS: 1 and 2).
• As used herein, the HRB linker in RSV F is formed by approximately residues 461-484 of RSV F protein (SEQ ID NOS: 1 and 2).
• As used herein, domain I (DI) is formed by approximately residues 26-50 and 309-401 of RSV F protein (SEQ ID NOS: 1 and 2).
• As used herein, domain II (DII) is formed by approximately residues 400-460 of RSV F protein (SEQ ID NOS: 1 and 2).
• As used herein, domain III (DIII) is formed by approximately residues 51-98 and 206-308, or residues 51-308 of RSV F protein (SEQ ID NOS: 1 and 2).
• As used herein, a “purified” protein or polypeptide is a protein or polypeptide which is recombinantly or synthetically produced, or produced by its natural host, and has been isolated from other components of the recombinant or synthetic production system or natural host such that the amount of the protein relative to other macromolecular components present in a composition is substantially higher than that present in a crude preparation. In general, a purified protein will be at least about 50% homogeneous and more preferably at least about 75%, at least about 80%, at least about 85%, at least about 90%, at least about 95% or substantially homogeneous.
• As used herein, “substantially free of lipids and lipoproteins” refers to compositions, proteins and polypeptides that are at least about 95% free of lipids and lipoproteins on a mass basis when protein and/or polypeptide (e.g., RSV F polypeptide) purity is observed on an SDS PAGE gel and total protein content is measured using either UV280 absorption or BCA analysis, and lipid and lipoprotein content is determined using the Phospholipase C assay (Wako, code no. 433-36201).
• As used herein, “close proximity” refers to a distance of not more than about 10 Å, not more than about 8 Å, not more than about 6 Å, not more than about 4 Å, or not more than about 2 Å. When two or more amino acid residues are in close proximity, the distance between the alpha carbons of the amino acid residues are is more than about 10 Å, not more than about 8 Å, not more than about 6 Å, not more than about 4 Å, or not more than about 2 Å.
• Features of RSV F protein suitable for use in this invention are described herein with reference to particular amino acids that are identified by the position of the amino acid in the sequence of RSV F protein from the A2 strain (SEQ ID NO:1). RSV F proteins can have the amino acid sequence of the F protein from the A2 strain or any other desired strain. When the F protein from a strain other than the A2 strain is used, the amino acids of the F protein are to be numbered with reference to the numbering of the F protein from the A2 strain, with the insertion of gaps as needed. This can be achieved by aligning the sequence of any desired RSV F protein with the F protein of the strain A2. Sequence alignments are preferably produced using the algorithm disclosed by Corpet, Nucleic Acids Research, 1998, 16(22):10881-10890, using default parameters (Blos sum 62 symbol comparison table, gap open penalty: 12, gap extension penalty: 2).
• As described and exemplified herein, the 3.2 Å x-ray crystal structure of a post-fusion form of RSV F protein has been determined. A model of the pre-fusion form of RSV F protein was made by comparing the RSV F post-fusion x-ray crystal structure to the known structures of the pre- and post-fusion parainfluenza virus F proteins. This model of the pre-fusion form of RSV F reveals structural features that differ from those of prior models of pre-fusion RSV F and allows for rational structure-based design of stabilized pre-fusion forms of RSV F.
• Accordingly, the invention relates to pre-fusion respiratory syncytial virus F (RSV F) polypeptides and/or proteins, and immunogenic compositions comprising pre-fusion RSV F polypeptides and/or proteins. The invention also relates to methods and use of pre-fusion RSV F polypeptides and/or proteins for inducing an immune response, and or by protective immunity against RSV. The invention also relates to nucleic acids that encode pre-fusion RSV F polypeptides and/or proteins.
• Generally, the immunogenic compositions comprise pre-fusion RSV F polypeptides and/or proteins that elicit neutralizing antibodies. For example, antibodies that bind to the same epitopes as Palivizumab, Motavizumab and 101F.
• Pre-fusion and post-fusion PIV F structures reveal en bloc shifts of domains and large rearrangements of HRA and HRB. In domain III of the pre-fusion PIV5 structure, HRA folds into three α-helices and two β-strands rather than the long post-fusion HRA helix (Yin et al, 2006). However, when pre-fusion and post-fusion conformations of individual PIV F domains are compared, the non-rearranging parts superimpose well. Superimposing post-fusion RSV F domains on their pre-fusion PIV5 F counterparts did not result in major clashes and positioned all the pairs of cysteines that form interdomain disulfide bonds in proximity to each other. The pre-fusion RSV F model obtained by thus combining information from the post-fusion RSV F x-ray crystal structure and the pre-fusion PIV5 F structure revealed a feature not apparent from prior homology models of pre-fusion RSV F based solely on the PIV5 pre-fusion structure (McLellan et al NSMB 2010 (141)). The helices of the Palivizumab/Motivizumab epitope are exposed on the surface of the pre-fusion RSV F trimer model, as they are on post-fusion RSV F trimer x-ray crystal structure (FIG. 9). In our pre-fusion RSV F model, the loop connecting β4 and HRC (part of domain III) could hinder access of Palivizumab or Motavizumab to their epitope. However, it is likely that the loop has sufficient flexibility to adopt an alternative conformation that permits antibody binding (FIG. 9B).
• The pre-fusion model disclosed herein, which is based on the RSV F post-fusion x-ray crystal structure and the PIV5 prefusion structure (Yin et al, 2006 (145)), shows that the elongated HRA helix of the post-fusion RSV F (residues 137-212) folds into strands and helices similar to the PIV5 pre-fusion crystal structure. The fusion peptide of RSV F, residues 137-154, forms a coil and helix that is packed into the RSV F pre-fusion head. Four helices are formed; helix a1 is approximately residues 145-157, helix a2 is approximately residues 158-167, helix a3 is approximately residues 168-176 and helix a4 is approximately residues 194-212. Two strands are formed; strand b1 is approximately residues 177-184, strand b2 is approximately residues 185-193 (FIG. 9).
• Pre-Fusion Conformation
• The invention includes pre-fusion RSV F polypeptides and proteins and immunogenic compositions that contain pre-fusion RSV F polypeptides and proteins. The RSV F protein and polypeptides can contain 1 or more amino acid replacements, deletions and/or additions that stabilize the pre-fusion conformation or destabilize the post-fusion conformation, for example, a pre-fusion RSV F stabilized with disulfide bonds, or a pre-fusion RSV F formed by destabilizing the post-fusion conformation.
• Stabilization Through Disulfide Bonds
• The RSV F pre-fusion model may be used as a guide to select amino acid residues that are in close proximity to each other in the pre-fusion conformation and that are no longer in close proximity in the post-fusion conformation. Such amino acids may be mutated to cysteine residues to allow disulfide formation that stabilizes the prefusion conformation, for example by preventing the HRB helix from associating with the HRA helix, thus preventing refolding to the post-fusion conformation.
• A stabilized pre-fusion RSV F protein of the invention may comprise a disulfide bond between any two structural elements, or between one structural element and the remainder of the RSV F protein, or between a structural element of one subunit of a trimer and a structural element of another subunit of the same trimer. Generally, a first amino acid in one structural element and a second amino acid that is in a different structural element, or the same structural element on a separate monomer, and that is also in close proximity to the first amino acid in the prefusion model are selected for replacement with cysteine. The distance between the residues (e.g., the alpha carbons) can be less than about 10 Å, less than about 8 Å, less than about 6 Å, less than about 5 Å, less than about 4 Å, or less than about 3 Å. The cysteine replacements of the first amino acid and the second amino acid, and a disulfide bond between them can be modeled. The length of the modeled disulfide bond, in some embodiments, does not exactly match the ˜2 Å length considered to be optimal for disulfide bonds. Preferably, the modeled disulfide bond length (distance between sulfur nuclei) is about 0.5 Å-3.5 Å, about 1.0 Å-3.0 Å, or about 1.5 Å-2.5 Å, which, due to structural flexibility, are expected to form disulfide bonds in the protein.
• In one embodiment, pre-fusion RSV F protein may be stabilized in the pre-fusion conformation through the introduction of at least one cysteine mutation in a first structural element in close proximity to at least one other cysteine (natural or introduced) in a second structural element or the remaining RSV F head region. Disulfide bonds form between the introduced cysteine that prevent the post-fusion HRA-HRB six-helix bundle from forming For example, pre-fusion RSV F protein may be stabilized in the pre-fusion conformation through the introduction of at least one cysteine mutation in the HRA helix region, HRB helix region, the fusion peptide, helix al, helix α2, helix α3, helix α4, strand [3], strand β2, DI, DII, or DIII in close proximity to at least one other cysteine (natural or introduced) in a different structural region (e.g., selected from the HRA helix region, HRB helix region, the fusion peptide, helix α1, helix α2, helix α3, helix α4, strand β1, strand β2, DI, DII, or DIII), thereby forming one or more disulfide bridges that would prevent the post-fusion HRA-HRB six-helix bundle from forming
• The cysteines may be introduced to the HRB or the HRB linker to create disulfide bonds between the cysteines. In one embodiment, one or more cysteines may be introduced to the HRB linker and helix region (approximately residues 452 to 515) to form disulfides with portions of the RSV F head region. In another embodiment, a disulfide bond between the HRB linker or helix and the remainder of the RSV F protein may be used to stabilize the protein in the pre-fusion conformation. In a preferred embodiment, a disulfide bridge is formed between the HRB pre-fusion stalk and the DI or DII region at the “top” of the head (e.g., M396C+F483C).
• In a preferred embodiment, the pre-fusion RSV F protein comprises two cysteine mutations, M396C and F483C, thereby comprising a disulfide bond between the HRB pre-fusion stalk and the DI region.
• In other preferred embodiments, a disulfide bridge is formed between the HRA region and DIII region. For example, the RSV F protein can contain amino acid replacements selected from the group consisting of V56C+V164C, 157C+S190C, T58C+V164C, N165C+V296C, K₁₆₈C+V296C, and combinations thereof.
• In one embodiment, the pre-fusion RSV F protein comprises a first cysteine mutation in the HRA region, and a second cysteine (natural or introduced) in the fusion peptide, helix α1, helix α2, helix α3, helix α4, strand β1, strand β2 of the pre-fusion HRA region, or DIII. In this embodiment, the protein comprises a disulfide bond between the first and second cysteine that prevents the post fusion HRA-HRB six-helix bundle from forming
• In one embodiment, the pre-fusion RSV F protein comprises a first cysteine mutation in the HRB helix region, and a second cysteine (natural or introduced) in DI or DII. In this embodiment, the protein comprises a disulfide bond between the first and second cysteine that prevents the post-fusion HRA-HRB six-helix bundle from forming
• In one embodiment, the pre-fusion RSV F protein comprises a first cysteine mutation in the fusion peptide, and a second cysteine (natural or introduced) in the HRA region, helix α1, helix α2, helix α3, helix α4, strand β1, strand β2 or DIII. In this embodiment, the protein comprises a disulfide bond between the first and second cysteine that prevents the post-fusion HRA elongated helix from forming
• In one embodiment, the pre-fusion RSV F protein comprises a first cysteine mutation in the helix α1, and a second cysteine (natural or introduced) in the HRA region, the fusion peptide, helix α2, helix α3, helix α4, strand β1, strand β2, or DIII. In this embodiment, the protein comprises a disulfide bond between the first and second cysteine that prevents the post-fusion HRA-HRB six-helix bundle from forming
• In one embodiment, the pre-fusion RSV F protein comprises a first cysteine mutation in the helix α2, and a second cysteine (natural or introduced) in the HRA region, the fusion peptide, helix α1, helix α3, helix α4, strand β1, strand β2, or DIII. In this embodiment, the protein comprises a disulfide bond between the first and second cysteine that prevents the post-fusion HRA-HRB six-helix bundle from forming
• In one embodiment, the pre-fusion RSV F protein comprises a first cysteine mutation in the helix α3, and a second cysteine (natural or introduced) in the HRA region, the fusion peptide, helix α1, helix α2, helix α4, strand β1, strand β2, or DIII. In this embodiment, the protein comprises a disulfide bond between the first and second cysteine that prevents the post-fusion HRA-HRB six-helix bundle from forming
• In one embodiment, the pre-fusion RSV F protein comprises a first cysteine mutation in the helix α4, and a second cysteine (natural or introduced) in the HRA region, the fusion peptide, helix α1, helix α2, helix α3, strand β1, strand β2, or DIII. In this embodiment, the protein comprises a disulfide bond between the first and second cysteine that prevents the post-fusion HRA-HRB six-helix bundle from forming
• In one embodiment, the pre-fusion RSV F protein comprises a first cysteine mutation in the strand β1, and a second cysteine (natural or introduced) in the HRA region, the fusion peptide, helix α1, helix α2, helix α3, helix α4, strand β2, or DIII. In this embodiment, the protein comprises a disulfide bond between the first and second cysteine that prevents the post-fusion HRA-HRB six-helix bundle from forming
• In one embodiment, the pre-fusion RSV F protein comprises a first cysteine mutation in the strand β2, and a cysteine (natural or introduced) in the HRA helix region, the fusion peptide, helix α1, helix α2, helix α3, helix α4, strand β1, DI, DII, or DIII. In this embodiment, the protein comprises a disulfide bond between the first and second cysteine that prevents the post-fusion HRA-HRB six-helix bundle from forming
• In one embodiment, the pre-fusion RSV F protein comprises a first cysteine mutation in the DI region, and a second cysteine (natural or introduced) in the HRB helix region. In this embodiment, the protein comprises a disulfide bond between the first and second cysteine that prevents the post-fusion HRA-HRB six-helix bundle from forming.
• In one embodiment, the pre-fusion RSV F protein comprises a first cysteine mutation in the DII region, and a second cysteine (natural or introduced) in the HRB helix region. In this embodiment, the protein comprises a disulfide bond between the first and second cysteine that prevents the post-fusion HRA-HRB six-helix bundle from forming.
• In one embodiment, the pre-fusion RSV F protein comprises a first cysteine mutation in the DIII region, and a second cysteine (natural or introduced) in the HRA helix region. In this embodiment, the protein comprises a disulfide bond between the first and second cysteine that prevents the post-fusion HRA-HRB six-helix bundle from forming.
• In another embodiment, the pre-fusion RSV F protein comprises a first introduced cysteine in the HRA helix region, HRB helix region, the fusion peptide, helix α1, helix α2, helix α3, helix α4, strand β1, strand β2, DI, DII, or DIII region and a second cysteine (natural or introduced) in any other region of the RSV F protein that is in close proximity to the introduced cysteine. In this embodiment, the protein comprises a disulfide bond between the first and second cysteine that prevents the post-fusion HRA-HRB six-helix bundle from forming.
• In a specific embodiment, the pre-fusion RSV F protein comprises two cysteine mutations selected from the group consisting of V56C+V164C, 157C+S190C, T58C+V164C, N165C+V296C, and K168C+V296C, and combinations thereof, thereby comprising a disulfide bridge between the HRA region and the DIII region.
• In one embodiment, the pre-fusion RSV F protein comprises two cysteine mutations, V56C and V164C, thereby comprising a disulfide bridge between the HRA region and the DIII region.
• In one embodiment, the pre-fusion RSV F protein comprises two cysteine mutations, I57C and S190C, thereby comprising a disulfide bridge between the HRA region and the DIII region.
• In one embodiment, the pre-fusion RSV F protein comprises two cysteine mutations, T58C and V164C, thereby comprising a disulfide bridge between the HRA region and the DIII region.
• In one embodiment, the pre-fusion RSV F protein comprises two cysteine mutations, N165C and T296C, thereby comprising a disulfide bridge between the HRA region and the DIII region.
• In one embodiment, the pre-fusion RSV F protein comprises two cysteine mutations, K168C and T296C, thereby comprising a disulfide bridge between the HRA region and the DIII region.
• In one embodiment, the pre-fusion RSV F protein comprises two cysteine mutations, M396C+F483C, thereby comprising a disulfide bridge between the HRB region and the DB region.
• The RSV F pre-fusion protein of the present invention is stabilized in the pre-fusion conformation by mutations that stabilize the pre-fusion subunit, which forms trimers.
• In some embodiments, the RSV F pre-fusion protein of the present invention is a trimer of RSV F monomers, and pre-fusion conformation is stabilized by one or more disulfide bonds between cysteine residues that are introduced into different monomers.
• Exemplary amino acid sequences of RSV F monomers that contain introduced cysteine residues that stabilize the pre-fusion conformation are presented below (SEQ ID NOS: 4-9). The presented sequences contain a signal peptide and a HIS tag (GGSAGSGHHHHHH; SEQ ID NO:3). The pre-fusion RSV F protein of the invention can contain any of the amino acid sequences shown below, with or without the signal peptide and/or HIS tag.

• >RSV F HRA disulfide1 (V56C + V164C)
  (SEQ ID NO: 4)
  MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRTGWYTSCITIELSNIKEN
  KCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPATNNRARRELPRFMNYTLNNAKKTNVTLSKKRK
  RRFLGFLLGVGSAIASGVAVSKVLHLEGECNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDK
  QLLPIVNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITN
  DQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLT
  RTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDV
  SSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYV
  KGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNGGSAGSGHHHHH
  H
  >RSV F HRA disulfide2 (I57C + S190C)
  (SEQ ID NO: 5)
  MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRTGWYTSVCTIELSNIKEN
  KCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPATNNRARRELPRFMNYTLNNAKKTNVTLSKKRK
  RRFLGFLLGVGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTCKVLDLKNYIDK
  QLLPIVNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITN
  DQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLT
  RTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDV
  SSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYV
  KGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNGGSAGSGHHHHH
  H
  >RSV F HRA disulfide3 (T58C + V164C)
  (SEQ ID NO: 6)
  MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRTGWYTSVICIELSNIKEN
  KCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPATNNRARRELPRFMNYTLNNAKKTNVTLSKKRK
  RRFLGFLLGVGSAIASGVAVSKVLHLEGECNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDK
  QLLPIVNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITN
  DQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLT
  RTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDV
  SSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYV
  KGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNGGSAGSGHHHHH
  H
  >RSV F HRA disulfide4 (N165C + V296C)
  (SEQ ID NO: 7)
  MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKEN
  KCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPATNNRARRELPRFMNYTLNNAKKTNVTLSKKRK
  RRFLGFLLGVGSAIASGVAVSKVLHLEGEVCKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDK
  QLLPIVNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITN
  DQKKLMSNNVQIVRQQSYSIMSIIKEECLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLT
  RTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDV
  SSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYV
  KGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNGGSAGSGHHHHH
  H
  >RSV F HRA disulfide5 (K168C + V296C)
  (SEQ ID NO: 8)
  MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKEN
  KCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPATNNRARRELPRFMNYTLNNAKKTNVTLSKKRK
  RRFLGFLLGVGSAIASGVAVSKVLHLEGEVNKICSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDK
  QLLPIVNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITN
  DQKKLMSNNVQIVRQQSYSIMSIIKEECLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLT
  RTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDV
  SSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYV
  KGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNGGSAGSGHHHHH
  H
  >RSV F HRB disulfide (M396C + F483C)
  (SEQ ID NO: 9)
  MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKEN
  KCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPATNNRARRELPRFMNYTLNNAKKTNVTLSKKRK
  RRFLGFLLGVGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDK
  QLLPIVNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITN
  DQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLT
  RTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKICTSKTDV
  SSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYV
  KGEPIINFYDPLVCPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNGGSAGSGHHHHH
  H

• Destabilization of Post-Fusion RSV F
• A major feature of the RSV F post-fusion structure is the 6-helix bundle in the stalk region. In the post-fusion conformation, the three HRA helices and the three HRB helices form a very stable 6-helix bundle. An alternative strategy for producing a stabilized pre-fusion RSV F protein of the invention, is by destabilizing the post-fusion 6-helix bundle, and/or preventing the 6-helix bundle formation (e.g., through deletion of the HRB helix, introduction of point mutations, addition of glycosylation or other modification sites).
• The 6-helix bundle formation may be prevented by deleting the HRA helix or the HRB helix.
• Preferably, the HRB helical region is deleted or mutated to prevent formation of the post-fusion conformation. The HRB region forms the stalk of the RSV F pre-fusion conformation, is in close proximity to the viral membrane and likely does not contain important neutralizing epitopes. Deletion of the HRB helix (residues 484 and C-terminal) may prevent the refolding of the RSV F protein from the pre-fusion state to the post-fusion state.
• A stabilized pre-fusion RSV F protein of the invention may comprise the RSV ectodomain sequence with the HRB region deleted or mutated, and preferably further comprises an additional mutation or deletion to the remaining ectodomain sequence. For example, the RSV ectodomain may comprise one or more introduced cysteines to create disulfide bridges that stabilize the prefusion structure as described herein, mutated or deleted furin cleavage sites, mutated or deleted fusion peptide sequence, or other mutations previously described in WO 2011/008974, incorporated herein in its entirety. The RSV ectodomain may be the ectodomain of a naturally occurring RSV F protein, or it may contain mutations in addition to the deletions and/or mutations of the HRA or HRB region.
• In one embodiment, the stabilized pre-fusion RSV F protein comprises an ectodomain of a naturally occurring RSV F protein in which the HRB region is deleted and one or more mutations that prevent cleavage at one or both of the furin cleavage sites (i.e.,amino acids 109 and 136 of SEQ ID NOS:1 and 2) are present.
• In one embodiment, the stabilized pre-fusion RSV F protein comprises an ectodomain of a naturally occurring RSV F protein in which the HRB region is deleted and the fusion peptide is mutated (amino acids 137 and 153 of SEQ ID NOS: 1 or 2). For example, this region can be deleted in whole or in part.
• In another embodiment, the stabilized pre-fusion RSV F protein comprises a wild-type RSV ectodomain in which the HRB region and the fusion peptide is deleted, in whole or in part.
• In another embodiment, the stabilized pre-fusion RSV F protein comprises a wild-type RSV ectodomain in which the HRB region is deleted and an oligomerization sequence has been added. When an oligomerization sequence is present, it is preferably a trimerization sequence. Suitable oligomerization sequences are well known in the art and include, for example, the coiled coil of the yeast GCN4 leucine zipper protein, trimerizing sequence from bacteriophage T4 fibritin (“foldon”), and the trimer domain of influenza HA.
• In another embodiment, the stabilized pre-fusion RSV F protein comprises a wild-type RSV ectodomain in which the HRB region is deleted and the p27 region is mutated (amino acids 110-136 of SEQ ID NOS: 1 or 2), including deletion of the p27 region in whole or in part. For example, lysine and/or arginine residues in the p27 region (about amino acids 110-136 of SEQ ID NOS: 1 or 2) can be substituted or deleted.
• In another embodiment, the stabilized pre-fusion RSV F protein comprises a wild-type RSV ectodomain in which the HRB region is deleted and an amino acid sequence that provides a protease cleavage site is added. Generally, the amino acid sequence that provides a protease cleavage site will be located within about 60 amino acids, about 50 amino acids, about 40 amino acids, about 30 amino acids, about 20 amino acids, about 10 amino acids, or substantially adjacent to the amino terminus of the transmembrane domain (amino acid 525 of SEQ ID NO:1 or 2).
• An exemplary amino acid sequence of an RSV F monomer in which the fusion peptide and HRB are deleted to stabilize the pre-fusion conformation is presented below (SEQ ID NO: 10). The presented sequence contains a signal peptide and a HIS tag (GGSAGSGHHHHHH; SEQ ID NO:3). The pre-fusion RSV F protein of the invention can contain the amino acid sequences shown below, with or without the signal peptide and/or HIS tag.

• >RSV F delHRB fusion peptide deletion HIS
  (SEQ ID NO: 10)
  MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELS
  NIKENKCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPATNNRARRELPRFMNYTLNNAKK
  TNVTLSKKRKRRSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDL
  KNYIDKQLLPIVNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSEL
  LSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTS
  PLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNL
  CNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVS
  NKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSGGSAGSGHHHHHH

• The stabilized pre-fusion RSV F protein of the invention may also be formed by hindering 6-helix bundle formation in the HRA or HRB regions (approximately residues 154-212 and 484 to 513, respectively) through engineered point mutations or introduction of glycosylation sites (e.g., AsnXaaSer/Thr; SEQ ID NO:11) or other modification sites (e.g., lipidation, phosphorylation). Glycosylation sites, or other post-translational modification sites or point mutations which interfere with 6-helix bundle formation through electrostatic or steric hindrance, can be introduced through the HRA or HRB helical regions. Glycosylation can interfere with 6-helix bundle formation and prevent flipping of the RSV F construct to the post-fusion conformation.
• A stabilized pre-fusion RSV F protein of the invention may comprise one or more mutations that form one or more glycosylation sites in the HRA or HRB helical regions. The RSV F protein may contain mutations or deletions in addition to those that introduce the glycosylation sites in the HRA or HRB helical regions.
• In one embodiment, the RSV F protein comprises S173N and N175T mutations and the pre-fusion RSV F protein has a glycosylation site oncurrent serine residue 173.
• In another embodiment, the RSV F protein comprises a mutation A177T, so that the pre-fusion RSV F protein has a glycosylation site on current residue N175.
• In another embodiment, the RSV F protein comprises G184N and S186T mutations and the pre-fusion RSV F protein has a glycosylation site on current residue G184.
• Chimeric Pre-Fusion F Structures with Relevant RSV F Epitopes
• The invention also relates to chimeric pre-fusion F proteins that contain neutralizing epitopes from RSV F protein. Generally, the chimeric pre-fusion F proteins comprise a stabilized F protein from a different virus, such as the Parainfluenza Virus (PIV1, PIV2, PIV3, PIV4, PIV5), Newcastle Disease Virus (NDV), Sendai virus (SeV), Hendra Virus, Nipah Virus (NiV), human metapneumovirus or avian metapneumovirus, in which portions that are exposed on the surface of the protein are replaced with corresponding portions of RSV F. Preferably, the portions contain neutralizing epitopes of RSV F.
• For example, any non-RSV (e.g., parainfluenza virus or metapneumovirus) F protein that is stabilized in the pre-fusion conformation (e.g., by virtue of a GCN trimer domain fused C-terminally to the HRB region), may be used as a template for the protein (i.e., an uncleaved NDV F-GCN fusion protein). For example, the SV5 of PIV5 pre-fusion F protein, described by Yin et al., 2006 (145) or the NDV pre-fusion F described by Swanson et al, 2010 (146) may be used in the chimeric F protein construct. The template may then be mutated to introduce known or suspected neutralizing epitopes of RSV F. Thus, the protein may have a pre-fusion F structure exhibiting the neutralizing epitopes, but not non-neutralizing epitopes, of RSV F. A clear benefit to this construct is that it would not raise non-neutralizing RSV F antibodies.
• A pre-fusion chimera protein of the invention may comprise a parainfluenza virus F protein, stabilized in the pre-fusion conformation that is mutated to introduce neutralizing epitopes of RSV F. The parainfluenza virus F protein may be any parainfluenza virus F protein, preferably the SV5 of PIV5 pre-fusion F protein, described by Yin et al., 2006 (147) or the NDV pre-fusion F described by Swanson et al, 2010 (146). Exemplary neutralizing epitopes that may be introduced by mutation include the epitopes disclosed in Table 1. For example, the amino acids that form the epitopes recognized by the antibodies listed in Table 1 can be introduced into the corresponding positions (e.g., identified by structural comparison, such as structure based alignment) of a non RSV-F protein (e.g., parainfluenza virus F protein or metapneumovirus F protein) that is stabilized in the pre-fusion conformation. For example, the chimeric F protein can contain the RSV F site A epitope or site C epitope. In particular example, the chimeric F protein contains one or more RSV F residues selected from the amino acid residues at positions 262-276 of RSV F. In another particular example, the chimeric F protein contains one or more RSV F residues selected from the amino acid residues at positions 429-447 of RSV F.

• TABLE 1
  Neutralizing epitopes of RSV Fa

  Siteb	mAb	Residues	Method	Reference
  A
  	11	N268I	Escapec	(149)
  A	151	K272N	Escape	(150)
  A	1129	S275F	Escape	(150)
  A	1153	N262S	Escape	(150)
  A	1200	K272N	Escape	(150)
  A	1214	N276Y	Escape	(150)
  A	1237	N276Y	Escape	(150)
  A	47F	N262Y, N268I	Escape	(151)
  A	7C2	K272E, K272T	Escape	(149)
  A	B4	K272T	Escape	(149)
  A	Fab 19d	I266M	Escape	(149)
  A	AK13A2	N262Y	Escape	(149)
  A	PVZe	K272M, K272Q, N268I	Escape	(152)
  A	PVZe	K272M, K272T,	Engineeredf	(153)
  		S275F
  A	MVZg	N262, N268, D269,	Structureh	(141)
  		K272, S275
  C	7.936	I432T, K433T, V447A	Escape	(154)
  C	9.432	S436F	Escape	(154)
  C	19d	R429S	Escape	(149)
  C	19d	R429K, R429S, G430A	Engineered	(153)
  C	20	R429S	Escape	(149)
  C	101F	K433T	Escape	(155)
  C	101F	K433D, K433L, K433N,	Engineered	(153)
  		K433Q,K433R
  C
  	101F	R429, I431, I432, K433,	Structure	(148)
  		T434, F435, S436, N437
  aResults of studies using peptide binding or peptide inhibition are not included in this table.
  bSites are based on the competition and cross-neutralization analysis of Beeler et al., 1989 (156).
  cAn escape mutation is included if it is the sole mutation in an antibody-resistant strain.
  dFab19 and 19 are unrelated antibodies. The similar names are coincidental.
  ePalivizumab
  fEngineered mutations in intact recombinant RSV F that allowed intact processing, full fusion activity and reduced monoclonal antibody binding to less than 15% of wild type are included.
  gMotavizumab
  hResidues from peptides in peptide-Fab complex structures are included if either their side chain or backbone atoms make significant contact with the antibody. The biological significance of the peptide-antibody interactions observed in these structural studies has been confirmed by other techniques.

• In one embodiment, the chimeric F protein of the invention comprises the HRA region of RSV F (residues 137-212) in place of the equivalent HRA residues of NDV-GCN pre-fusion F. Thus, prefusion F protein (NDV-GCN) is expressed with potential neutralizing epitope sites (HRA region of RSV F) on the top of the pre-fusion F head, permitting neutralizing RSV F antibodies to be elicited. Additional neutralizing epitopes may be added if desired, for example the motavizumab epitope or the 101F epitope.
• An exemplary amino acid sequence of a chimeric protein containing prefusion NDV F mutated to include RSV F HRA amino acid sequences is presented below (SEQ ID NO: 13). The presented sequences contain a signal peptide, a GCN-trimerization domain and a HIS tag. The chimeric pre-fusion F protein of the invention can contain the amino acid sequence shown below, with or without the signal peptide and/or GCN-trimerization domain and/or HIS tag.

• NDV RSV HRA prefusion (underlined portion is RSV HRA, italicized
  portion is C-terminal GCN trimeric domain and HIS6 (SEQ ID NO: 12)
  affinity purification tag).
  (SEQ ID NO: 13)
  MGSRSSTRIPVPLMLTVRVMLALSCVCPTSALDGRPLAAAGIVVTGDKAVNIYTSSQTGSIII
  KLLPNMPKDKEACAKAPLEAYNRTLTTLLTPLGDSIRRIQESVTTSGGGKQGRLIGAIIGFLG
  FLLGVGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDK
  QLLPIVNKQSCIKITQQVGVELNLYLTELTTVFGPQITSPALTQLTIQALYNLAGGNMDYLLT
  KLGVGNNQLSSLISSGLITGNPILYDSQTQLLGIQVTLPSVGNLNNMRATYLETLSVSTTKGF
  ASALVPKVVTQVGSVIEELDTSYCIETDLDLYCTRIVTFPMSPGIYSCLSGNTSACMYSKTEG
  ALTTPYMTLKGSVIANCKMTTCRCADPPGIISQNYGEAVSLIDRQSCNILSLDGITLRLSGEFD
  ATYQKNISIQDSQVIVTGNLDISTELGNVNNSISNALDKLEESNSKLDKVEDKIEEILSKIYHIEN
  EIARIKKLIGEAGGPLVPRGSHHHHHH

• The RSV F Glycoprotein
• The F glycoprotein of RSV directs viral penetration by fusion between the virion envelope and the host cell plasma membrane. It is a type I single-pass integral membrane protein having four general domains: N-terminal ER-translocating signal sequence (SS), ectodomain (ED), transmembrane domain (TM), and a cytoplasmic tail (CT). CT contains a single palmitoylated cysteine residue. The sequence of F protein is highly conserved among RSV isolates, but is constantly evolving (7). Unlike most paramyxoviruses, the F protein in RSV can mediate entry and syncytium formation independent of the other viral proteins (HN is usually necessary in addition to F in other paramyxoviruses).
• The hRSV F mRNA is translated into a 574 amino acid precursor protein designated F₀, which contains a signal peptide sequence at the N-terminus that is removed by a signal peptidase in the endoplasmic reticulum. F₀is cleaved at two sites (a.a. 109/110 and 136/137) by cellular proteases (in particular furin) in the trans-Golgi, removing a short glycosylated intervening sequence and generating two subunits designated F₁(˜50 kDa; C-terminus; residues 137-574) and F₂(˜20 kDa; N-terminus; residues 1-109) (See, e.g.,FIG. 4A). F₁contains a hydrophobic fusion peptide at its N-terminus and also two hydrophobic heptad-repeat regions (HRA and HRB). HRA is near the fusion peptide and HRB is near to the transmembrane domain (See, e.g.,FIG. 4A). The F₁-F₂heterodimers are assembled as homotrimers in the virion.
• RSV exists as a single serotype but has two antigenic subgroups: A and B. The F glycoproteins of the two groups are about 90% identical. The A subgroup, the B subgroup, or a combination or hybrid of both can be used in the invention. An example sequence for the A subgroup is SEQ ID NO: 1 (A2 strain; GenBank GI: 138251; Swiss Prot P03420), and for the B subgroup is SEQ ID NO: 2 (18537 strain; GI: 138250; Swiss Prot P13843). SEQ ID NO:1 and SEQ ID NO:2 are both 574 amino acid sequences. The signal peptide in A2 strain is a.a. 1-21, but in 18537 strain it is 1-22. In both sequences the TM domain is from about a.a. 530-550, but has alternatively been reported as 525-548.

• SEQ ID NO: 1

  1	MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIE	60
  61	LSNIKENKCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPPTNNRARRELPRFMNYTLN	120
  121	NAKKTNVTLSKKRKRRFLGFLLGVGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVS	180
  181	LSNGVSVLTSKVLDLKNYIDKQLLPIVNKQSCSISNIETVIEFQQKNNRLLEITREFSVN	240
  241	AGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYV	300
  301	VQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKV	360
  361	QSNRVFCDTMNSLTLPSEINLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKT	420
  421	KCTASNKNRGIIKTFSNGCDYVSNKGMDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDP	480
  481	LVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLS	540
  541	LIAVGLLLYCKARSTPVTLSKDQLSGINNIAFSN	574

  SEQ ID NO: 2

  1	MELLIHRSSAIFLTLAVNALYLTSSQNITEEFYQSTCSAVSRGYFSALRTGWYTSVITIE	60
  61	LSNIKETKCNGTDTKVKLIKQELDKYKNAVTELQLLMQNTPAANNRARREAPQYMNYTIN	120
  121	TTKNLNVSISKKRKRRFLGFLLGVGSAIASGIAVSKVLHLEGEVNKIKNALLSTNKAVVS	180
  181	LSNGVSVLTSKVLDLKNYINNRLLPIVNQQSCRISNIETVIEFQQMNSRLLEITREFSVN	240
  241	AGVTTPLSTYMLTNSELLSLINDMPITNDQKKLMSSNVQIVRQQSYSIMSIIKEEVLAYV	300
  301	VQLPIYGVIDTPCWKLHTSPLCTTNIKEGSNICLTRTDRGWYCDNAGSVSFFPQADTCKV	360
  361	QSNRVFCDTMNSLTLPSEVSLCNTDIFNSKYDCKIMTSKTDISSSVITSLGAIVSCYGKT	420
  421	KCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKLEGKNLYVKGEPIINYYDP	480
  481	LVFPSDEFDASISQVNEKINQSLAFIRRSDELLHNVNTGKSTTNIMITTIIIVIIVVLLS	540
  541	LIAIGLLLYCKAKNTPVTLSKDQLSGINNIAFSK	574

• The invention may use any desired RSV F amino acid sequence, such as the amino acid sequence of SEQ ID NO: 1 or 2, or a sequence having identity to SEQ ID NO: 1 or 2. Typically it will have at least 75% identity to SEQ ID NO: 1 or 2 e.g., at least 80%, at least 85%, at least 90%, at least 95%, at least 97%, at least 98%, at least 99%,identity to SEQ ID NO:1 or 2. The sequence may be found naturally in RSV.
• Where the invention uses an ectodomain of F protein, in whole or in part, it may comprise:
• (i) a polypeptide comprising about amino acid 22-525 of SEQ ID NO: 1.
• (ii) a polypeptide comprising about amino acids 23-525 of SEQ ID NO: 2.
• (iii) a polypeptide comprising an amino acid sequence having at least 75% identity (e.g., at least 80%, at least 85%, at least 90%, at least 95%, at least 97%, at least 98%, at least 99% identity) to (i) or (ii).
• (iv) a polypeptide comprising a fragment of (i), (ii) or (iii), wherein the fragment comprises at least one F protein epitope. The fragment will usually be at least about 100 amino acids long, e.g., at least about 150, at least about 200, at least about 250, at least about 300, at least about 350, at least about 400, at least about 450 amino acids long.
• The ectodomain can be an F₀form with or without the signal peptide, or can comprise two separate peptide chains (e.g., an F₁subunit and a F₂subunit) that are associated with each other, for example, the subunits may be linked by a disulfide bridge. Accordingly, all or a portion of about amino acid 101 to about 161, such as amino acids 110-136, may be absent from the ectodomain. Thus the ectodomain, in whole or in part, can comprise:
• (v) a first peptide chain and a second peptide chain that is associated with the first polypeptide chain, where the first peptide chain comprises an amino acid sequence having at least 75% identity (e.g., at least 80%, at least 85%, at least 90%, at least 95%, at least 97%, at least 98%, at least 99%, or even 100% identity) to about amino acid 22 to about amino acid 101 of SEQ ID NO: 1 or to about amino acid 23 to about amino acid 101 of SEQ ID NO: 2, and the second peptide chain comprises an amino acid sequence having at least 75% identity (e.g., at least 80%, at least 85%, at least 90%, at least 95%, at least 97%, at least 98%, at least 99%, or even 100% identity) to about amino acid 162 to about 525 of SEQ ID NO: 1 or to about amino acid 162 to 525 of SEQ ID NO: 2.
• (vi) a first peptide chain and a second peptide chain that is associated with the first polypeptide chain, where the first peptide chain comprises an amino acid sequence comprising a fragment of about amino acid 22 to about amino acid 101 of SEQ ID NO: 1 or of about amino acid 23 to aboutamino acid 109 of SEQ ID NO: 2, and the second peptide chain comprises a fragment of about amino acid 162 to about amino acid 525 of SEQ ID NO: 1 or of about amino acid 161 to about amino acid 525 of SEQ ID NO: 2. One or both of the fragments will comprise at least one F protein epitope. The fragment in the first peptide chain will usually be at least 20 amino acids long, e.g., at least 30, at least 40, at least 50, at least 60, at least 70, at least 80 amino acids long. The fragment in the second peptide chain will usually be at least 100 amino acids long, e.g., at least 150, at least 200, at least 250, at least 300, at least 350, at least 400, at least 450 amino acids long.
• (vii) a molecule obtainable by furin digestion of (i), (ii), (iii) or (iv).
• Thus an amino acid sequence used with the invention may be found naturally within RSV F protein (e.g., a soluble RSV F protein lacking TM and CT, about amino acids 522-574 of SEQ ID NOS: 1 or 2), and/or it may have one or more (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30) single amino acid mutations (insertions, deletions or substitutions) relative to a natural RSV sequence. For instance, it is known to mutate F proteins to eliminate their furin cleavage sequences, thereby preventing intracellular processing. In certain embodiments, the RSV F protein lacks TM and CT (about amino acids 522-574 of SEQ ID NOS: 1 or 2) and contains one or more (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30) single amino acid mutations (insertions, deletions or substitutions) relative to a natural RSV sequence.
• Furin-Cleavage, Trypsin-Cleavage and Fusion Peptide Mutations
• If desired, post-fusion RSV F polypeptides or proteins may contain one or more mutations, for example, mutations that prevent cleavage at one or both of the furin cleavage sites (i.e.,amino acids 109 and 136 of SEQ ID NOS: 1 and 2), that prevent cleavage of or introduce trypsin cleavage sites, mutations in the p27 region, and/or mutation in the fusion peptide. Such mutations can prevent aggregation of the soluble polypeptides or proteins and thereby facilitate purifications, can prevent cell-cell fusion if the RSV F protein is expressed on the surface of a cell, such as by expression from a viral replicon (e.g., alphavirus replicon particles), or if the RSV F protein is a component of a virus-like particle.
• Examples of suitable furin cleavage mutations include replacement of amino acid residues 106-109 of SEQ ID NO: 1 or 2 with RARK (SEQ ID NO:14), RARQ (SEQ ID NO:15), QAQN (SEQ ID NO:16), or IEGR (SEQ ID NO:17). Alternatively, or in addition, amino acid residues 133-136 of SEQ ID NO: 1 or 2 can be replaced with RKKK (SEQ ID NO:18), ΔΔΔR, QNQN (SEQ ID NO:19), QQQR (SEQ ID NO:20) or IEGR (SEQ ID NO:17). (A indicates that the amino acid residue has been deleted.) These furin cleavage mutations can be combined, if desired, with other mutations described herein, such as trypsin cleavage mutations and fusion peptide mutations.
• Examples of suitable trypsin cleavage mutations include deletion of any lysine or arginine residue between about position 101 and position 161 of SEQ ID NO:1 or 2, or replacement of any such lysine or arginine residue with an amino acid other than lysine or arginine. For example, lysine and/or arginine residues in the p27 region (about amino acids 110-136 of SEQ ID NOS: 1 or 2) can be substituted or deleted, including deletion of the p27 region in whole or in part.
• The mutations described herein can be combined, if desired, in any combination. For example, furin mutations can be combined with partial or complete deletion of the fusion peptide region and/or deletion of the HRA or HRB helical region.
• In addition to the mutations described above, e.g., furin-cleavage and fusion peptide mutations, or alternatively, soluble RSV F polypeptides or proteins, such as those that lack the transmembrane region and cytoplasmic tail, or HRA and HRB deletions, or cysteine mutations, may contain one or more oligomerization sequences. When an oligomerization sequence is present, it is preferably a trimerization sequence. Suitable oligomerization sequences are well known in the art and include, for example, the coiled coil of the yeast GCN4 leucine zipper protein, trimerizing sequence from bacteriophage T4 fibritin (“foldon”), and the trimer domain of influenza HA. These and other suitable oligomerization sequences are described in greater detail herein.
• In particular embodiments, the sequence of the carboxy terminus of the RSV F polypeptide or protein, starting fromposition 480, is

• (GCN)

  (SEQ ID NO: 21)

  PLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNDKIEEILSKIYH

  IENEIARIKKLIGE

  (HA)

  (SEQ ID NO: 22)

  PLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNEKFHQIEKEFSE

  VEGRIQDLEK

  (Idealized helix)

  (SEQ ID NO: 23)

  PLVFPSDEFDASISQINEKINQILAFIRKIDELLHNIN

  (foldon short)

  (SEQ ID NO: 24)

  PLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNGSGYIPEAPRDG

  QAYVRKDGEWVLLSTFL;

  or

  (foldon long)

  (SEQ ID NO: 25)

  PLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNNKNDDKGSGYIP

  EAPRDGQAYVRKDGEWVLLSTFL

• If desired, RSV F polypeptides or proteins that contain a transmembrane region may contain an added amino acid sequence that provides a protease cleavage site. This type of RSV F polypeptide or protein can be produced by expression on the surface of a cell, and recovered in soluble form after cleavage from the cell surface using an appropriate protease. Generally, the amino acid sequence that provides a protease cleavage site will be located within about 60 amino acids, about 50 amino acids, about 40 amino acids, about 30 amino acids, about 20 amino acids, about 10 amino acids, or substantially adjacent to the amino terminus of the transmembrane domain (amino acid 525 of SEQ ID NO:1 or 2). Many suitable amino acid sequences that are cleaved by commercially available proteases are well-known in the art. For example, thrombin cleaves the sequence LVPR (SEQ ID NO:26), factor Xa cleaves the sequence IEGR (SEQ ID NO:17) and enterokinase cleaves the sequence DDDDK (SEQ ID NO:27). These amino acid sequences can be introduced into an RSV F polypeptide.
• Immunogenic polypeptides used according to the invention will usually be isolated or purified. Thus, they will not be associated with molecules with which they are normally, if applicable, found in nature. For example, an F protein used with the invention will not be in the form of a RSV virion (although it may be in the form of an artificial virion, such as a virosome or VLP).
• Polypeptides will usually be prepared by expression in a recombinant host system. Generally, they (e.g., RSV ecto-domains) are produced by expression of recombinant constructs that encode the ecto-domains in suitable recombinant host cells, although any suitable methods can be used. Suitable recombinant host cells include, for example, insect cells (e.g.,Aedes aegypti, Autographa californica, Bombyx mori, Drosophila melanogaster, Spodoptera frugiperda, andTrichoplusia ni), mammalian cells (e.g., human, non-human primate, horse, cow, sheep, dog, cat, and rodent (e.g., hamster), avian cells (e.g., chicken, duck, and geese), bacteria (e.g.,E. coli, Bacillus subtilis, andStreptococcusspp.), yeast cells (e.g.,Saccharomyces cerevisiae, Candida albicans, Candida maltosa, Hansenual polymorpha, Kluyveromyces fragilis, Kluyveromyces lactis, Pichia guillerimondii, Pichia pastoris, Schizosaccharomyces pombeandYarrowia lipolytica), Tetrahymena cells (e.g.,Tetrahymena thermophila) or combinations thereof. Many suitable insect cells and mammalian cells are well-known in the art. Suitable insect cells include, for example, Sf9 cells, Sf21 cells, Tn5 cells, Schneider S2 cells, and High Five cells (a clonal isolate derived from the parentalTrichoplusia niBTI-TN-5B1-4 cell line (Invitrogen)). Suitable mammalian cells include, for example, Chinese hamster ovary (CHO) cells, human embryonic kidney cells (HEK293 cells, typically transformed by shearedadenovirus type 5 DNA), NIH-3T3 cells, 293-T cells, Vero cells, HeLa cells, PERC.6 cells (ECACC deposit number 96022940), Hep G2 cells, MRC-5 (ATCC CCL-171), WI-38 (ATCC CCL-75), fetal rhesus lung cells (ATCC CL-160), Madin-Darby bovine kidney (“MDBK”) cells, Madin-Darby canine kidney (“MDCK”) cells (e.g., MDCK (NBL2), ATCC CCL34; or MDCK 33016, DSM ACC 2219), baby hamster kidney (BHK) cells, such as BHK21-F, HKCC cells, and the like. Suitable avian cells include, for example, chicken embryonic stem cells (e.g., EBx® cells), chicken embryonic fibroblasts, chicken embryonic germ cells, duck cells (e.g., AGE1.CR and AGE1.CR.pIX cell lines (ProBioGen) which are described, for example, inVaccine27:4975-4982 (2009) and WO2005/042728), EB66 cells, and the like.
• Suitable insect cell expression systems, such as baculovirus systems, are known to those of skill in the art and described in, e.g., Summers and Smith,Texas Agricultural Experiment Station BulletinNo. 1555 (1987). Materials and methods for baculovirus/insert cell expression systems are commercially available in kit form from, inter alia, Invitrogen, San Diego Calif. Avian cell expression systems are also known to those of skill in the art and described in, e.g., U.S. Pat. Nos. 5,340,740; 5,656,479; 5,830,510; 6,114,168; and 6,500,668; European Patent No. EP 0787180B; European Patent Application No. EP03291813.8; WO 03/043415; and WO 03/076601. Similarly, bacterial and mammalian cell expression systems are also known in the art and described in, e.g.,Yeast Genetic Engineering(Barr et al., eds., 1989) Butterworths, London.
• Recombinant constructs encoding pre-fusion RSV F protein can be prepared in suitable vectors using conventional methods. A number of suitable vectors for expression of recombinant proteins in insect or mammalian cells are well-known and conventional in the art. Suitable vectors can contain a number of components, including, but not limited to one or more of the following: an origin of replication; a selectable marker gene; one or more expression control elements, such as a transcriptional control element (e.g., a promoter, an enhancer, a terminator), and/or one or more translation signals; and a signal sequence or leader sequence for targeting to the secretory pathway in a selected host cell (e.g., of mammalian origin or from a heterologous mammalian or non-mammalian species). For example, for expression in insect cells a suitable baculovirus expression vector, such as pFastBac (Invitrogen), is used to produce recombinant baculovirus particles. The baculovirus particles are amplified and used to infect insect cells to express recombinant protein. For expression in mammalian cells, a vector that will drive expression of the construct in the desired mammalian host cell (e.g., Chinese hamster ovary cells) is used.
• Pre-fusion RSV F protein polypeptides can be purified using any suitable methods. For example, methods for purifying pre-fusion RSV F polypeptides by immunoaffinity chromatography are known in the art. Ruiz-Arguello et al.,J. Gen. Virol.,85:3677-3687 (2004). Suitable methods for purifying desired proteins including precipitation and various types of chromatography, such as hydrophobic interaction, ion exchange, affinity, chelating and size exclusion are well-known in the art. Suitable purification schemes can be created using two or more of these or other suitable methods. If desired, the pre-fusion RSV F protein polypeptides can include a “tag” that facilitates purification, such as an epitope tag or a HIS tag. Such tagged polypeptides can conveniently be purified, for example from conditioned media, by chelating chromatography or affinity chromatography.
• The pre-fusion RSV F polypeptides may also be produced in situ by expression of nucleic acids that encode them in the cells of a subject. For example, by expression of a self-replicating RNA described herein.
• Polypeptides may include additional sequences in addition to the pre-fusion RSV sequences. For example, a polypeptide may include a sequence to facilitate purification (e.g., a poly-His sequence). Similarly, for expression purposes, the natural leader peptide of F protein may be substituted for a different one. For example,reference 6 used a honeybee melittin leader peptide in place of the natural one.
• Self-Replicating RNA
• The pre-fusion RSV-F polypeptides described herein can be produced by expression of recombinant nucleic acids that encode the polypeptides in the cells of a subject. Preferred nucleic acids that can be administered to a subject to cause the production of pre-fusion RSV-F polypeptides are self-replicating RNA molecules. The self-replicating RNA molecules of the invention are based on the genomic RNA of RNA viruses, but lack the genes encoding one or more structural proteins. The self-replicating RNA molecules are capable of being translated to produce non-structural proteins of the RNA virus and heterologous proteins encoded by the self-replicating RNA.
• The self-replicating RNA generally contains at least one or more genes selected from the group consisting of viral replicase, viral proteases, viral helicases and other nonstructural viral proteins, and also comprise 5′- and 3′-end cis-active replication sequences, and if desired, a heterologous sequences that encode a desired amino acid sequences (e.g., a protein, an antigen). A subgenomic promoter that directs expression of the heterologous sequence can be included in the self-replicating RNA. If desired, the heterologous sequence may be fused in frame to other coding regions in the self-replicating RNA and/or may be under the control of an internal ribosome entry site (IRES).
• Self-replicating RNA molecules of the invention can be designed so that the self-replicating RNA molecule cannot induce production of infectious viral particles. This can be achieved, for example, by omitting one or more viral genes encoding structural proteins that are necessary for the production of viral particles in the self-replicating RNA. For example, when the self-replicating RNA molecule is based on an alpha virus, such as Sinebis virus (SIN), Semliki forest virus and Venezuelan equine encephalitis virus (VEE), one or more genes encoding viral structural proteins, such as capsid and/or envelope glycoproteins, can be omitted. If desired, self-replicating RNA molecules of the invention can be designed to induce production of infectious viral particles that are attenuated or virulent, or to produce viral particles that are capable of a single round of subsequent infection.
• A self-replicating RNA molecule can, when delivered to a vertebrate cell even without any proteins, lead to the production of multiple daughter RNAs by transcription from itself (or from an antisense copy of itself). The self-replicating RNA can be directly translated after delivery to a cell, and this translation provides a RNA-dependent RNA polymerase which then produces transcripts from the delivered RNA. Thus the delivered RNA leads to the production of multiple daughter RNAs. These transcripts are antisense relative to the delivered RNA and may be translated themselves to provide in situ expression of a gene product, or may be transcribed to provide further transcripts with the same sense as the delivered RNA which are translated to provide in situ expression of the encoded RSV-F polypeptide.
• One suitable system for achieving self-replication is to use an alphavirus-based RNA replicon. These + stranded replicons are translated after delivery to a cell to give of a replicase (or replicase-transcriptase). The replicase is translated as a polyprotein which auto cleaves to provide a replication complex which creates genomic − strand copies of the + strand delivered RNA. These − strand transcripts can themselves be transcribed to give further copies of the + stranded parent RNA and also to give a subgenomic transcript which encodes the RSV-F polypeptide. Translation of the subgenomic transcript thus leads to in situ expression of the RSV-F polypeptide by the infected cell. Suitable alphavirus replicons can use a replicase from a sindbis virus, a semliki forest virus, an eastern equine encephalitis virus, a venezuelan equine encephalitis virus, etc.
• A preferred self-replicating RNA molecule thus encodes (i) a RNA-dependent RNA polymerase which can transcribe RNA from the self-replicating RNA molecule and (ii) an RSV-F polypeptide. The polymerase can be an alphavirus replicase e.g. comprising alphavirus protein nsP4.
• Whereas natural alphavirus genomes encode structural virion proteins in addition to the non structural replicase polyprotein, it is preferred that an alphavirus based self-replicating RNA molecule of the invention does not encode alphavirus structural proteins. Thus the self replicating RNA can lead to the production of genomic RNA copies of itself in a cell, but not to the production of RNA-containing alphavirus virions. The inability to produce these virions means that, unlike a wild-type alphavirus, the self-replicating RNA molecule cannot perpetuate itself in infectious form. The alphavirus structural proteins which are necessary for perpetuation in wild-type viruses are absent from self replicating RNAs of the invention and their place is taken by gene(s) encoding the desired gene product, such that the subgenomic transcript encodes the desired gene product rather than the structural alphavirus virion proteins.
• Thus a self-replicating RNA molecule useful with the invention may have two open reading frames. The first (5′) open reading frame encodes a replicase; the second (3′) open reading frame encodes an RSV-F polypeptide. In some embodiments the RNA may have additional (downstream) open reading frames e.g. that encode further desired gene products. A self-replicating RNA molecule can have a 5′ sequence which is compatible with the encoded replicase.
• In one aspect, the self-replicating RNA molecule is derived from or based on an alphavirus. In other aspects, the self-replicating RNA molecule is derived from or based on a virus other than an alphavirus, preferably, a positive-stranded RNA viruses, and more preferably a picornavirus, flavivirus, rubivirus, pestivirus, hepacivirus, calicivirus, or coronavirus. Suitable wild-type alphavirus sequences are well-known and are available from sequence depositories, such as the American Type Culture Collection, Rockville, Md. Representative examples of suitable alphaviruses include Aura (ATCC VR-368), Bebaru virus (ATCC VR-600, ATCC VR-1240), Cabassou (ATCC VR-922), Chikungunya virus (ATCC VR-64, ATCC VR-1241), Eastern equine encephalomyelitis virus (ATCC VR-65, ATCC VR-1242), Fort Morgan (ATCC VR-924), Getah virus (ATCC VR-369, ATCC VR-1243), Kyzylagach (ATCC VR-927), Mayaro (ATCC VR-66), Mayaro virus (ATCC VR-1277), Middleburg (ATCC VR-370), Mucambo virus (ATCC VR-580, ATCC VR-1244), Ndumu (ATCC VR-371), Pixuna virus (ATCC VR-372, ATCC VR-1245), Ross River virus (ATCC VR-373, ATCC VR-1246), Semliki Forest (ATCC VR-67, ATCC VR-1247), Sindbis virus (ATCC VR-68, ATCC VR-1248), Tonate (ATCC VR-925), Triniti (ATCC VR-469), Una (ATCC VR-374), Venezuelan equine encephalomyelitis (ATCC VR-69, ATCC VR-923, ATCC VR-1250 ATCC VR-1249, ATCC VR-532), Western equine encephalomyelitis (ATCC VR-70, ATCC VR-1251, ATCC VR-622, ATCC VR-1252), Whataroa (ATCC VR-926), and Y-62-33 (ATCC VR-375).
• The self-replicating RNA may be associated with a delivery system. The self-replicating RNA may be administered with or without an adjuvant.
RNA Delivery Systems
• The self-replicating RNA of the invention are suitable for delivery in a variety of modalities, such as naked RNA delivery or in combination with lipids, polymers or other compounds that facilitate entry into the cells. Self-replicating RNA molecules of the present invention can be introduced into target cells or subjects using any suitable technique, e.g., by direct injection, microinjection, electroporation, lipofection, biolystics, and the like. The self-replicating RNA molecule may also be introduced into cells by way of receptor-mediated endocytosis. See e.g., U.S. Pat. No. 6,090,619; Wu and Wu, J. Biol. Chem., 263:14621 (1988); and Curiel et al., Proc. Natl. Acad. Sci. USA, 88:8850 (1991). For example, U.S. Pat. No. 6,083,741 discloses introducing an exogenous nucleic acid into mammalian cells by associating the nucleic acid to a polycation moiety (e.g., poly-L-lysine having 3-100 lysine residues), which is itself coupled to an integrin receptor-binding moiety (e.g., a cyclic peptide having the sequence Arg-Gly-Asp).
• The self-replicating RNA molecule of the present invention can be delivered into cells via amphiphiles. See e.g., U.S. Pat. No. 6,071,890. Typically, a nucleic acid molecule may form a complex with the cationic amphiphile. Mammalian cells contacted with the complex can readily take it up.
• The self-replicating RNA can be delivered as naked RNA (e.g. merely as an aqueous solution of RNA) but, to enhance entry into cells and also subsequent intercellular effects, the self-replicating RNA is preferably administered in combination with a delivery system, such as a particulate or emulsion delivery system. A large number of delivery systems are well known to those of skill in the art. Such delivery systems include, for example liposome-based delivery (Debs and Zhu (1993) WO 93/24640; Mannino and Gould-Fogerite (1988) BioTechniques 6(7): 682-691; Rose U.S. Pat. No. 5,279,833; Brigham (1991) WO 91/06309; and Feigner et al. (1987) Proc. Natl. Acad. Sci. USA 84: 7413-7414), as well as use of viral vectors (e.g., adenoviral (see, e.g., Berns et al. (1995) Ann NY Acad. Sci. 772: 95-104; Ali et al. (1994) Gene Ther. 1: 367-384; and Haddada et al. (1995) Curr. Top. Microbiol. Immunol. 199 (Pt 3): 297-306 for review), papillomaviral, retroviral (see, e.g., Buchscher et al. (1992) J. Virol. 66(5) 2731-2739; Johann et al. (1992) J. Virol. 66 (5): 1635-1640 (1992); Sommerfelt et al., (1990) Virol. 176:58-59; Wilson et al. (1989) J. Virol. 63:2374-2378; Miller et al., J. Virol. 65:2220-2224 (1991); Wong-Staal et al., PCT/US94/05700, and Rosenburg and Fauci (1993) in Fundamental Immunology, Third Edition Paul (ed) Raven Press, Ltd., New York and the references therein, and Yu et al., Gene Therapy (1994) supra.), and adeno-associated viral vectors (see, West et al. (1987) Virology 160:38-47; Carter et al. (1989) U.S. Pat. No. 4,797,368; Carter et al. WO 93/24641 (1993); Kotin (1994) Human Gene Therapy 5:793-801; Muzyczka (1994) J. Clin. Invst. 94:1351 and Samulski (supra) for an overview of AAV vectors; see also, Lebkowski, U.S. Pat. No. 5,173,414; Tratschin et al. (1985) Mol. Cell. Biol. 5(11):3251-3260; Tratschin, et al. (1984) Mol. Cell. Biol., 4:2072-2081; Hermonat and Muzyczka (1984) Proc. Natl. Acad. Sci. USA, 81:6466-6470; McLaughlin et al. (1988) and Samulski et al. (1989) J. Virol., 63:03822-3828), and the like.
• Three particularly useful delivery systems are (i) liposomes (ii) non-toxic and biodegradable polymer microparticles (iii) cationic submicron oil-in-water emulsions.
• Liposomes
• Various amphiphilic lipids can form bilayers in an aqueous environment to encapsulate a RNA-containing aqueous core as a liposome. These lipids can have an anionic, cationic or zwitterionic hydrophilic head group. Formation of liposomes from anionic phospholipids dates back to the 1960s, and cationic liposome-forming lipids have been studied since the 1990s. Some phospholipids are anionic whereas other are zwitterionic. Suitable classes of phospholipid include, but are not limited to, phosphatidylethanolamines, phosphatidylcholines, phosphatidylserines, and phosphatidylglycerols, and some useful phospholipids are listed in Table 2. Useful cationic lipids include, but are not limited to, dioleoyl trimethylammonium propane (DOTAP), 1,2-distearyloxy-N,N-dimethyl-3-aminopropane (DSDMA), 1,2-dioleyloxy-N,N-dimethyl-3-aminopropane (DODMA), 1,2-dilinoleyloxy-N,N-dimethyl-3-aminopropane (DLinDMA), 1,2-dilinolenyloxy-N,N-dimethyl-3-aminopropane (DLenDMA). Zwitterionic lipids include, but are not limited to, acyl zwitterionic lipids and ether zwitterionic lipids. Examples of useful zwitterionic lipids are DPPC, DOPC and dodecylphosphocholine. The lipids can be saturated or unsaturated.
• Liposomes can be formed from a single lipid or from a mixture of lipids. A mixture may comprise (i) a mixture of anionic lipids (ii) a mixture of cationic lipids (iii) a mixture of zwitterionic lipids (iv) a mixture of anionic lipids and cationic lipids (v) a mixture of anionic lipids and zwitterionic lipids (vi) a mixture of zwitterionic lipids and cationic lipids or (vii) a mixture of anionic lipids, cationic lipids and zwitterionic lipids. Similarly, a mixture may comprise both saturated and unsaturated lipids. For example, a mixture may comprise DSPC (zwitterionic, saturated), Dlin DMA (cationic, unsaturated), and/or DMPG (anionic, saturated). Where a mixture of lipids is used, not all of the component lipids in the mixture need to be amphiphilic e.g. one or more amphiphilic lipids can be mixed with cholesterol.
• The hydrophilic portion of a lipid can be PEGylated (i.e. modified by covalent attachment of a polyethylene glycol). This modification can increase stability and prevent non-specific adsorption of the liposomes. For instance, lipids can be conjugated to PEG using techniques such as those disclosed in Heyes et al. (2005)J Controlled Release107:276-287.
• A mixture of DSPC, Dlin DMA, PEG-DMPG and cholesterol is used in the examples. A separate aspect of the invention is a liposome comprising DSPC, Dlin DMA, PEG-DMG and cholesterol. This liposome preferably encapsulates RNA, such as a self-replicating RNA e.g. encoding an immunogen.
• Liposomes are usually divided into three groups: multilamellar vesicles (MLV); small unilamellar vesicles (SUV); and large unilamellar vesicles (LUV). MLVs have multiple bilayers in each vesicle, forming several separate aqueous compartments. SUVs and LUVs have a single bilayer encapsulating an aqueous core; SUVs typically have a diameter≦50 nm, and LUVs have a diameter>50 nm Liposomes useful with of the invention are ideally LUVs with a diameter in the range of 50-220 nm. For a composition comprising a population of LUVs with different diameters: (i) at least 80% by number should have diameters in the range of 20-220 nm, (ii) the average diameter (Zav, by intensity) of the population is ideally in the range of 40-200 nm, and/or (iii) the diameters should have a polydispersity index<0.2.
• Techniques for preparing suitable liposomes are well known in the art e.g. see Liposomes: Methods and Protocols, Volume 1: Pharmaceutical Nanocarriers: Methods and Protocols. (ed. Weissig). Humana Press, 2009. ISBN 160327359X; Liposome Technology, volumes I, II & III. (ed. Gregoriadis). Informa Healthcare, 2006; and Functional Polymer Colloids and Microparticles volume 4 (Microspheres, microcapsules & liposomes). (eds. Arshady & Guyot). Citus Books, 2002. One useful method involves mixing (i) an ethanolic solution of the lipids (ii) an aqueous solution of the nucleic acid and (iii) buffer, followed by mixing, equilibration, dilution and purification (Heyes et al. (2005)J Controlled Release107:276-87).
• RNA is preferably encapsulated within the liposomes, and so the liposome forms a outer layer around an aqueous RNA-containing core. This encapsulation has been found to protect RNA from RNase digestion. The liposomes can include some external RNA (e.g. on the surface of the liposomes), but at least half of the RNA (and ideally all of it) is encapsulated.
• Polymeric Microparticles
• Various polymers can form microparticles to encapsulate or adsorb RNA. The use of a substantially non-toxic polymer means that a recipient can safely receive the particles, and the use of a biodegradable polymer means that the particles can be metabolised after delivery to avoid long-term persistence. Useful polymers are also sterilisable, to assist in preparing pharmaceutical grade formulations.
• Suitable non-toxic and biodegradable polymers include, but are not limited to, poly(α-hydroxy acids), polyhydroxy butyric acids, polylactones (including polycaprolactones), polydioxanones, polyvalerolactone, polyorthoesters, polyanhydrides, polycyanoacrylates, tyrosine-derived polycarbonates, polyvinyl-pyrrolidinones or polyester-amides, and combinations thereof.
• In some embodiments, the microparticles are formed from poly(α-hydroxy acids), such as a poly(lactides) (“PLA”), copolymers of lactide and glycolide such as a poly(D,L-lactide-co-glycolide) (“PLG”), and copolymers of D,L-lactide and caprolactone. Useful PLG polymers include those having a lactide/glycolide molar ratio ranging, for example, from 20:80 to 80:20 e.g. 25:75, 40:60, 45:55, 55:45, 60:40, 75:25. Useful PLG polymers include those having a molecular weight between, for example, 5,000-200,000 Da e.g. between 10,000-100,000, 20,000-70,000, 40,000-50,000 Da.
• The microparticles ideally have a diameter in the range of 0.02 μm to 8 μm. For a composition comprising a population of microparticles with different diameters at least 80% by number should have diameters in the range of 0.03-7 μm.
• Techniques for preparing suitable microparticles are well known in the art e.g. see Functional Polymer Colloids and Microparticles volume 4 (Microspheres, microcapsules & liposomes). (eds. Arshady & Guyot). Citus Books, 2002; Polymers in Drug Delivery. (eds. Uchegbu & Schatzlein). CRC Press, 2006. (in particular chapter 7) andMicroparticulate Systems for the Delivery of Proteins and Vaccines. (eds. Cohen & Bernstein). CRC Press, 1996. To facilitate adsorption of RNA, a microparticle may include a cationic surfactant and/or lipid e.g. as disclosed in O'Hagan et al. (2001)J Virology75:9037-9043; and Singh et al. (2003)Pharmaceutical Research20: 247-251. An alternative way of making polymeric microparticles is by molding and curing e.g. as disclosed in WO2009/132206.
• Microparticles of the invention can have a zeta potential of between 40-100 mV.
• RNA can be adsorbed to the microparticles, and adsorption is facilitated by including cationic materials (e.g. cationic lipids) in the microparticle.
• Oil-in-Water Cationic Emulsions
• Oil-in-water emulsions are known for adjuvanting influenza vaccines e.g. the MF59™ adjuvant in the FLUAD™ product, and the AS03 adjuvant in the PREPANDRIX™ product. RNA delivery according to the present invention can utilise an oil-in-water emulsion, provided that the emulsion includes one or more cationic molecules. For instance, a cationic lipid can be included in the emulsion to provide a positive droplet surface to which negatively-charged RNA can attach.
• The emulsion comprises one or more oils. Suitable oil(s) include those from, for example, an animal (such as fish) or a vegetable source. The oil is ideally biodegradable (metabolisable) and biocompatible. Sources for vegetable oils include nuts, seeds and grains. Peanut oil, soybean oil, coconut oil, and olive oil, the most commonly available, exemplify the nut oils. Jojoba oil can be used e.g. obtained from the jojoba bean. Seed oils include safflower oil, cottonseed oil, sunflower seed oil, sesame seed oil and the like. In the grain group, corn oil is the most readily available, but the oil of other cereal grains such as wheat, oats, rye, rice, teff, triticale and the like may also be used. 6-10 carbon fatty acid esters of glycerol and 1,2-propanediol, while not occurring naturally in seed oils, may be prepared by hydrolysis, separation and esterification of the appropriate materials starting from the nut and seed oils. Fats and oils from mammalian milk are metabolizable and so may be used. The procedures for separation, purification, saponification and other means necessary for obtaining pure oils from animal sources are well known in the art.
• Most fish contain metabolizable oils which may be readily recovered. For example, cod liver oil, shark liver oils, and whale oil such as spermaceti exemplify several of the fish oils which may be used herein. A number of branched chain oils are synthesized biochemically in 5-carbon isoprene units and are generally referred to as terpenoids. Squalane, the saturated analog to squalene, can also be used. Fish oils, including squalene and squalane, are readily available from commercial sources or may be obtained by methods known in the art.
• Other useful oils are the tocopherols, particularly in combination with squalene. Where the oil phase of an emulsion includes a tocopherol, any of the α, β, γ, δ, ε or ξ tocopherols can be used, but α-tocopherols are preferred. D-α-tocopherol and DL-α-tocopherol can both be used. A preferred α-tocopherol is DL-α-tocopherol. An oil combination comprising squalene and a tocopherol (e.g. DL-α-tocopherol) can be used.
• Preferred emulsions comprise squalene, a shark liver oil which is a branched, unsaturated terpenoid (C₃₀H₅₀; [(CH₃)₂C[═CHCH₂CH₂C(CH₃)]₂═CHCH₂—]₂; 2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene; CAS RN 7683-64-9).
• The oil in the emulsion may comprise a combination of oils e.g. squalene and at least one further oil.
• The aqueous component of the emulsion can be plain water (e.g. w.f.i.) or can include further components e.g. solutes. For instance, it may include salts to form a buffer e.g. citrate or phosphate salts, such as sodium salts. Typical buffers include: a phosphate buffer; a Tris buffer; a borate buffer; a succinate buffer; a histidine buffer; or a citrate buffer. A buffered aqueous phase is preferred, and buffers will typically be included in the 5-20 mM range.
• The emulsion also includes a cationic lipid. Preferably this lipid is a surfactant so that it can facilitate formation and stabilisation of the emulsion. Useful cationic lipids generally contains a nitrogen atom that is positively charged under physiological conditions e.g. as a tertiary or quaternary amine. This nitrogen can be in the hydrophilic head group of an amphiphilic surfactant. Useful cationic lipids include, but are not limited to: 1,2-dioleoyloxy-3-(trimethylammonio)propane (DOTAP), 3′-1N-(N′,N′-Dimethylaminoethane)-carbamoyll Cholesterol (DC Cholesterol), dimethyldioctadecyl-ammonium (DDA e.g. the bromide), 1,2-Dimyristoyl-3-Trimethyl-AmmoniumPropane (DMTAP), dipalmitoyl(C16:0)trimethyl ammonium propane (DPTAP), distearoyltrimethylammonium propane (DSTAP). Other useful cationic lipids are: benzalkonium chloride (BAK), benzethonium chloride, cetramide (which contains tetradecyltrimethylammonium bromide and possibly small amounts of dedecyltrimethylammonium bromide and hexadecyltrimethyl ammonium bromide), cetylpyridinium chloride (CPC), cetyl trimethylammonium chloride (CTAC), N,N′,N′-polyoxyethylene (10)-N-tallow-1,3-diaminopropane, dodecyltrimethylammonium bromide, hexadecyltrimethyl-ammonium bromide, mixed alkyl-trimethylammonium bromide, benzyldimethyldodecylammonium chloride, benzyldimethylhexadecyl-ammonium chloride, benzyltrimethylammonium methoxide, cetyldimethylethylammonium bromide, dimethyldioctadecyl ammonium bromide (DDAB), methylbenzethonium chloride, decamethonium chloride, methyl mixed trialkyl ammonium chloride, methyl trioctylammonium chloride), N,N-dimethyl-N-[2-(2-methyl-4-(1,1,3,3tetramethylbutyl)-phenoxy]-ethoxy)ethyl]-benzenemetha-naminium chloride (DEBDA), dialkyldimethylammonium salts, [1-(2,3-dioleyloxy)-propyl]-N,N,N,trimethylammonium chloride, 1,2-diacyl-3-(trimethylammonio) propane (acyl group=dimyristoyl, dipalmitoyl, distearoyl, dioleoyl), 1,2-diacyl-3 (dimethylammonio)propane (acyl group=dimyristoyl, dipalmitoyl, distearoyl, dioleoyl), 1,2-dioleoyl-3-(4′-trimethyl-ammonio)butanoyl-sn-glycerol, 1,2-dioleoyl 3-succinyl-sn-glycerol choline ester, cholesteryl (4′-trimethylammonio) butanoate), N-alkyl pyridinium salts (e.g. cetylpyridinium bromide and cetylpyridinium chloride), N-alkylpiperidinium salts, dicationic bolaform electrolytes (C12Me6; C12BU6), dialkylglycetylphosphorylcholine, lysolecithin, L-α dioleoylphosphatidylethanolamine, cholesterol hemisuccinate choline ester, lipopolyamines, including but not limited to dioctadecylamidoglycylspermine (DOGS), dipalmitoyl phosphatidylethanol-amidospermine (DPPES), lipopoly-L (or D)-lysine (LPLL, LPDL), poly (L (or D)-lysine conjugated to N-glutarylphosphatidylethanolamine, didodecyl glutamate ester with pendant amino group (ĈGluPhCnN), ditetradecyl glutamate ester with pendant amino group (Cl4GIuCnN+), cationic derivatives of cholesterol, including but not limited to cholesteryl-3 β-oxysuccinamidoethylenetrimethylammonium salt, cholesteryl-3 β-oxysuccinamidoethylene-dimethylamine, cholesteryl-3 β-carboxyamidoethylenetrimethylammonium salt, and cholesteryl-3 β-carboxyamidoethylenedimethylamine. Other useful cationic lipids are described in US 2008/0085870 and US 2008/0057080, which are incorporated herein by reference.
• The cationic lipid is preferably biodegradable (metabolisable) and biocompatible.
• In addition to the oil and cationic lipid, an emulsion can include a non-ionic surfactant and/or a zwitterionic surfactant. Such surfactants include, but are not limited to: the polyoxyethylene sorbitan esters surfactants (commonly referred to as the Tweens), especiallypolysorbate 20 andpolysorbate 80; copolymers of ethylene oxide (EO), propylene oxide (PO), and/or butylene oxide (BO), sold under the DOWFAX™ tradename, such as linear EO/PO block copolymers; octoxynols, which can vary in the number of repeating ethoxy (oxy-1,2-ethanediyl) groups, with octoxynol-9 (Triton X-100, or t-octylphenoxypolyethoxyethanol) being of particular interest; (octylphenoxy)polyethoxyethanol (IGEPAL CA-630/NP-40); phospholipids such as phosphatidylcholine (lecithin); polyoxyethylene fatty ethers derived from lauryl, cetyl, stearyl and oleyl alcohols (known as Brij surfactants), such as triethyleneglycol monolauryl ether (Brij 30); polyoxyethylene-9-lauryl ether; and sorbitan esters (commonly known as the Spans), such as sorbitan trioleate (Span 85) and sorbitan monolaurate. Preferred surfactants for including in the emulsion are polysorbate 80 (Tween 80; polyoxyethylene sorbitan monooleate), Span 85 (sorbitan trioleate), lecithin and Triton X-100.
• Mixtures of these surfactants can be included in theemulsion e.g. Tween 80/Span 85 mixtures, orTween 80/Triton-X100 mixtures. A combination of a polyoxyethylene sorbitan ester such as polyoxyethylene sorbitan monooleate (Tween 80) and an octoxynol such as t-octylphenoxy-polyethoxyethanol (Triton X-100) is also suitable. Another useful combination compriseslaureth 9 plus a polyoxyethylene sorbitan ester and/or an octoxynol. Useful mixtures can comprise a surfactant with a HLB value in the range of 10-20 (e.g.polysorbate 80, with a HLB of 15.0) and a surfactant with a HLB value in the range of 1-10 (e.g. sorbitan trioleate, with a HLB of 1.8).
• Preferred amounts of oil (% by volume) in the final emulsion are between 2-20% e.g. 5-15%, 6-14%, 7-13%, 8-12%. A squalene content of about 4-6% or about 9-11% is particularly useful.
• Preferred amounts of surfactants (% by weight) in the final emulsion are between 0.001% and 8%. For example: polyoxyethylene sorbitan esters (such as polysorbate 80) 0.2 to 4%, in particular between 0.4-0.6%, between 0.45-0.55%, about 0.5% or between 1.5-2%, between 1.8-2.2%, between 1.9-2.1%, about 2%, or 0.85-0.95%, or about 1%; sorbitan esters (such as sorbitan trioleate) 0.02 to 2%, in particular about 0.5% or about 1%; octyl- or nonylphenoxy polyoxyethanols (such as Triton X-100) 0.001 to 0.1%, in particular 0.005 to 0.02%; polyoxyethylene ethers (such as laureth 9) 0.1 to 8%, preferably 0.1 to 10% and in particular 0.1 to 1% or about 0.5%.
• The absolute amounts of oil and surfactant, and their ratio, can be varied within wide limits while still forming an emulsion. A skilled person can easily vary the relative proportions of the components to obtain a desired emulsion, but a weight ratio of between 4:1 and 5:1 for oil and surfactant is typical (excess oil).
• An important parameter for ensuring immunostimulatory activity of an emulsion, particularly in large animals, is the oil droplet size (diameter). The most effective emulsions have a droplet size in the submicron range. Suitably the droplet sizes will be in the range 50-750 nm. Most usefully the average droplet size is less than 250 nm e.g. less than 200 nm, less than 150 nm. The average droplet size is usefully in the range of 80-180 nm Ideally, at least 80% (by number) of the emulsion's oil droplets are less than 250 nm in diameter, and preferably at least 90%. Apparatuses for determining the average droplet size in an emulsion, and the size distribution, are commercially available. These typically use the techniques of dynamic light scattering and/or single-particle optical sensing e.g. the Accusizer™ and Nicomp™ series of instruments available from Particle Sizing Systems (Santa Barbara, USA), or the Zetasizer™ instruments from Malvern Instruments (UK), or the Particle Size Distribution Analyzer instruments from Horiba (Kyoto, Japan).
• Ideally, the distribution of droplet sizes (by number) has only one maximum i.e. there is a single population of droplets distributed around an average (mode), rather than having two maxima. Preferred emulsions have a polydispersity of <0.4 e.g. 0.3, 0.2, or less.
• Suitable emulsions with submicron droplets and a narrow size distribution can be obtained by the use of microfluidisation. This technique reduces average oil droplet size by propelling streams of input components through geometrically fixed channels at high pressure and high velocity. These streams contact channel walls, chamber walls and each other. The results shear, impact and cavitation forces cause a reduction in droplet size. Repeated steps of microfluidisation can be performed until an emulsion with a desired droplet size average and distribution are achieved.
• As an alternative to microfluidisation, thermal methods can be used to cause phase inversion. These methods can also provide a submicron emulsion with a tight particle size distribution.
• Preferred emulsions can be filter sterilized i.e. their droplets can pass through a 220 nm filter. As well as providing a sterilization, this procedure also removes any large droplets in the emulsion.
• In certain embodiments, the cationic lipid in the emulsion is DOTAP. The cationic oil-in-water emulsion may comprise from about 0.5 mg/ml to about 25 mg/ml DOTAP. For example, the cationic oil-in-water emulsion may comprise DOTAP at from about 0.5 mg/ml to about 25 mg/ml, from about 0.6 mg/ml to about 25 mg/ml, from about 0.7 mg/ml to about 25 mg/ml, from about 0.8 mg/ml to about 25 mg/ml, from about 0.9 mg/ml to about 25 mg/ml, from about 1.0 mg/ml to about 25 mg/ml, from about 1.1 mg/ml to about 25 mg/ml, from about 1.2 mg/ml to about 25 mg/ml, from about 1.3 mg/ml to about 25 mg/ml, from about 1.4 mg/ml to about 25 mg/ml, from about 1.5 mg/ml to about 25 mg/ml, from about 1.6 mg/ml to about 25 mg/ml, from about 1.7 mg/ml to about 25 mg/ml, from about 0.5 mg/ml to about 24 mg/ml, from about 0.5 mg/ml to about 22 mg/ml, from about 0.5 mg/ml to about 20 mg/ml, from about 0.5 mg/ml to about 18 mg/ml, from about 0.5 mg/ml to about 15 mg/ml, from about 0.5 mg/ml to about 12 mg/ml, from about 0.5 mg/ml to about 10 mg/ml, from about 0.5 mg/ml to about 5 mg/ml, from about 0.5 mg/ml to about 2 mg/ml, from about 0.5 mg/ml to about 1.9 mg/ml, from about 0.5 mg/ml to about 1.8 mg/ml, from about 0.5 mg/ml to about 1.7 mg/ml, from about 0.5 mg/ml to about 1.6 mg/ml, from about 0.6 mg/ml to about 1.6 mg/ml, from about 0.7 mg/ml to about 1.6 mg/ml, from about 0.8 mg/ml to about 1.6 mg/ml, about 0.5 mg/ml, about 0.6 mg/ml, about 0.7 mg/ml, about 0.8 mg/ml, about 0.9 mg/ml, about 1.0 mg/ml, about 1.1 mg/ml, about 1.2 mg/ml, about 1.3 mg/ml, about 1.4 mg/ml, about 1.5 mg/ml, about 1.6 mg/ml, about 12 mg/ml, about 18 mg/ml, about 20 mg/ml, about 21.8 mg/ml, about 24 mg/ml, etc. In an exemplary embodiment, the cationic oil-in-water emulsion comprises from about 0.8 mg/ml to about 1.6 mg/ml DOTAP, such as 0.8 mg/ml, 1.2 mg/ml, 1.4 mg/ml or 1.6 mg/ml.
• In certain embodiments, the cationic lipid is DC Cholesterol. The cationic oil-in-water emulsion may comprise DC Cholesterol at from about 0.1 mg/ml to about 5 mg/ml DC Cholesterol. For example, the cationic oil-in-water emulsion may comprise DC Cholesterol from about 0.1 mg/ml to about 5 mg/ml, from about 0.2 mg/ml to about 5 mg/ml, from about 0.3 mg/ml to about 5 mg/ml, from about 0.4 mg/ml to about 5 mg/ml, from about 0.5 mg/ml to about 5 mg/ml, from about 0.62 mg/ml to about 5 mg/ml, from about 1 mg/ml to about 5 mg/ml, from about 1.5 mg/ml to about 5 mg/ml, from about 2 mg/ml to about 5 mg/ml, from about 2.46 mg/ml to about 5 mg/ml, from about 3 mg/ml to about 5 mg/ml, from about 3.5 mg/ml to about 5 mg/ml, from about 4 mg/ml to about 5 mg/ml, from about 4.5 mg/ml to about 5 mg/ml, from about 0.1 mg/ml to about 4.92 mg/ml, from about 0.1 mg/ml to about 4.5 mg/ml, from about 0.1 mg/ml to about 4 mg/ml, from about 0.1 mg/ml to about 3.5 mg/ml, from about 0.1 mg/ml to about 3 mg/ml, from about 0.1 mg/ml to about 2.46 mg/ml, from about 0.1 mg/ml to about 2 mg/ml, from about 0.1 mg/ml to about 1.5 mg/ml, from about 0.1 mg/ml to about 1 mg/ml, from about 0.1 mg/ml to about 0.62 mg/ml, about 0.15 mg/ml, about 0.3 mg/ml, about 0.6 mg/ml, about 0.62 mg/ml, about 0.9 mg/ml, about 1.2 mg/ml, about 2.46 mg/ml, about 4.92 mg/ml, etc. In an exemplary embodiment, the cationic oil-in-water emulsion comprises from about 0.62 mg/ml to about 4.92 mg/ml DC Cholesterol, such as 2.46 mg/ml.
• In certain embodiments, the cationic lipid is DDA. The cationic oil-in-water emulsion may comprise from about 0.1 mg/ml to about 5 mg/ml DDA. For example, the cationic oil-in-water emulsion may comprise DDA at from about 0.1 mg/ml to about 5 mg/ml, from about 0.1 mg/ml to about 4.5 mg/ml, from about 0.1 mg/ml to about 4 mg/ml, from about 0.1 mg/ml to about 3.5 mg/ml, from about 0.1 mg/ml to about 3 mg/ml, from about 0.1 mg/ml to about 2.5 mg/ml, from about 0.1 mg/ml to about 2 mg/ml, from about 0.1 mg/ml to about 1.5 mg/ml, from about 0.1 mg/ml to about 1.45 mg/ml, from about 0.2 mg/ml to about 5 mg/ml, from about 0.3 mg/ml to about 5 mg/ml, from about 0.4 mg/ml to about 5 mg/ml, from about 0.5 mg/ml to about 5 mg/ml, from about 0.6 mg/ml to about 5 mg/ml, from about 0.73 mg/ml to about 5 mg/ml, from about 0.8 mg/ml to about 5 mg/ml, from about 0.9 mg/ml to about 5 mg/ml, from about 1.0 mg/ml to about 5 mg/ml, from about 1.2 mg/ml to about 5 mg/ml, from about 1.45 mg/ml to about 5 mg/ml, from about 2 mg/ml to about 5 mg/ml, from about 2.5 mg/ml to about 5 mg/ml, from about 3 mg/ml to about 5 mg/ml, from about 3.5 mg/ml to about 5 mg/ml, from about 4 mg/ml to about 5 mg/ml, from about 4.5 mg/ml to about 5 mg/ml, about 1.2 mg/ml, about 1.45 mg/ml, etc. Alternatively, the cationic oil-in-water emulsion may comprise DDA at about 20 mg/ml, about 21 mg/ml, about 21.5 mg/ml, about 21.6 mg/ml, about 25 mg/ml. In an exemplary embodiment, the cationic oil-in-water emulsion comprises from about 0.73 mg/ml to about 1.45 mg/ml DDA, such as 1.45 mg/ml.
• Catheters or like devices may be used to deliver the self-replicating RNA molecules of the invention, as naked RNA or in combination with a delivery system, into a target organ or tissue. Suitable catheters are disclosed in, e.g., U.S. Pat. Nos. 4,186,745; 5,397,307; 5,547,472; 5,674,192; and 6,129,705, all of which are incorporated herein by reference.
• The present invention includes the use of suitable delivery systems, such as liposomes, polymer microparticles or submicron emulsion microparticles with encapsulated or adsorbed self-replicating RNA, to deliver a self-replicating RNA molecule that encodes an RSV-F polypeptide, for example, to elicit an immune response alone, or in combination with another macromolecule. The invention includes liposomes, microparticles and submicron emulsions with adsorbed and/or encapsulated self-replicating RNA molecules, and combinations thereof.
• As demonstrated further in the Examples, the self-replicating RNA molecules associated with liposomes and submicron emulsion microparticles can be effectively delivered to the host cell, and can induce an immune response to the protein encoded by the self-replicating RNA.
• Immunogenic Compositions
• The invention provides immunogenic compositions. The immunogenic compositions may include a single active immunogenic agent, or several immunogenic agents. For example, the immunogenic composition can comprise pre-fusion RSV F polypeptides or a combination of pre-fusion chimeric RSV F polypeptides. The immunogenic composition can comprise a self-replicating RNA encoding a pre-fusion RSV-F polypeptide, and preferably also comprises a suitable delivery system, such as liposomes, polymeric microparticles, an oil-in-water emulsion and combinations thereof.
• Immunogenic compositions of the invention may also comprise one or more immunoregulatory agents. Preferably, one or more of the immunoregulatory agents include one or more adjuvants, for example two, three, four or more adjuvants. The adjuvants may include a TH1 adjuvant and/or a TH2 adjuvant, further discussed below.
• In another embodiment, an immunogenic composition of the invention comprises a polypeptide that displays an epitope present in a pre-fusion conformation of RSV-F glycoprotein.
• In another embodiment, an immunogenic composition of the invention comprises one or more pre-fusion chimera proteins based on two different pre-fusion non-RSV (F proteins (e.g., metapneumovirus, parainfluenza, such asPIV5, NDV), in which both have the same RSV F neutralizing epitopes mutated on the protein surface.
• The compositions of the invention are preferably suitable for administration to a mammalian subject, such as a human, and include one or more pharmaceutically acceptable carrier(s) and/or excipient(s), including adjuvants. A thorough discussion of such components is available in reference 29. Compositions will generally be in aqueous form. When the composition is an immunogenic composition, it will elicit an immune response when administered to a mammal, such as a human. The immunogenic composition can be used to prepare a vaccine formulation for immunizing a mammal.
• The immunogenic compositions may include a single active immunogenic agent, or several immunogenic agents. For example, the pre-fusion RSV F protein can be full length or a ecto-domain polypeptide and can be in a single form (e.g., uncleaved monomer, cleaved monomer, uncleaved trimer, cleaved trimer) or in two or more forms (e.g., a mixture of uncleaved monomer and uncleaved trimer or a dynamic equilibrium between uncleaved monomer and uncleaved trimer). In addition, the compositions can contain a pre-fusion RSV F protein and one or more other RSV proteins (e.g., a G protein and/or an M protein) and/or it may be combined with immunogens from other pathogens.
• The composition may include preservatives such as thiomersal or 2-phenoxyethanol. It is preferred, however, that the vaccine should be substantially free from (i.e., less than 5 μg/ml) mercurial material, e.g., thiomersal-free Immunogenic compositions containing no mercury are more preferred. Preservative-free immunogenic compositions are particularly preferred.
• To control tonicity, it is preferred to include a physiological salt, such as a sodium salt. Sodium chloride (NaCl) is preferred, which may be present at between 1 and 20 mg/ml. Other salts that may be present include potassium chloride, potassium dihydrogen phosphate, disodium phosphate dehydrate, magnesium chloride, calcium chloride, and the like.
• Compositions will generally have an osmolality of between 200 mOsm/kg and 400 mOsm/kg, preferably between 240-360 mOsm/kg, and will more preferably fall within the range of 290-310 mOsm/kg.
• Compositions may include one or more buffers. Typical buffers include: a phosphate buffer; a Tris buffer; a borate buffer; a succinate buffer; a histidine buffer (particularly with an aluminum hydroxide adjuvant); or a citrate buffer. Buffers will typically be included in the 5-20 mM range. The pH of a composition will generally be between 5.0 and 8.1, and more typically between 6.0 and 8.0, e.g., between 6.5 and 7.5, or between 7.0 and 7.8. A process of the invention may therefore include a step of adjusting the pH of the bulk vaccine prior to packaging.
• The composition is preferably sterile. The composition is preferably non-pyrogenic, e.g., containing<1 EU (endotoxin unit, a standard measure) per dose, and preferably <0.1 EU per dose. The composition is preferably gluten free. Human vaccines are typically administered in a dosage volume of about 0.5 ml, although a half dose (i.e., about 0.25 ml) may be administered to children.
• Adjuvants
• Compositions of the invention, that contain RSV-F polypeptides, or nucleic acids that encode RSV-F polypeptides, may also include one or more adjuvants, for example two, three, four or more adjuvants, which can function to enhance the immune responses (humoral and/or cellular) elicited in a patient who receives the composition. The adjuvants may include a TH1 adjuvant and/or a TH2 adjuvant. Adjuvants which may be used in compositions of the invention include, but are not limited to:
• • Mineral-containing compositions. Mineral-containing compositions suitable for use as adjuvants in the invention include mineral salts, such as calcium salts and aluminum salts (or mixtures thereof). The invention includes mineral salts such as hydroxides (e.g. oxyhydroxides), phosphates (e.g. hydroxyphosphates, orthophosphates), sulphates, etc., or mixtures of different mineral compounds, with the compounds taking any suitable form (e.g. gel, crystalline, amorphous, etc.), and with adsorption being preferred. Calcium salts include calcium phosphate (e.g., the “CAP” particles disclosed in ref. 38). Aluminum salts include hydroxides, phosphates, sulfates, and the like. The mineral containing compositions may also be formulated as a particle of metal salt (39). Aluminum salt adjuvants are described in more detail below.
  • Oil emulsion compositions (see in more detail below). Oil emulsion compositions suitable for use as adjuvants in the invention include squalene-water emulsions, such as MF59 (5% Squalene, 0.5% Tween 80 and 0.5% Span, formulated into submicron particles using a microfluidizer).
  • Cytokine-inducing agents (see in more detail below). Cytokine-inducing agents suitable for use in the invention include toll-like receptor 7 (TLR7) agonists (e.g. benzonaphthyridine compounds disclosed in WO 2009/111337.
  • Saponins (chapter 22 of ref. 74), which are a heterologous group of sterol glycosides and triterpenoid glycosides that are found in the bark, leaves, stems, roots and even flowers of a wide range of plant species. Saponin from the bark of theQuillaia saponariaMolina tree have been widely studied as adjuvants. Saponin can also be commercially obtained fromSmilax ornata(sarsaprilla),Gypsophilla paniculata(brides veil), andSaponaria officianalis(soap root). Saponin adjuvant formulations include purified formulations, such as QS21, as well as lipid formulations, such as ISCOMs. QS21 is marketed as STIMULON (TM). Saponin compositions have been purified using HPLC and RP-HPLC. Specific purified fractions using these techniques have been identified, including QS7, QS17, QS18, QS21, QH-A, QH-B and QH-C. Preferably, the saponin is QS21. A method of production of QS21 is disclosed in ref. 40. Saponin formulations may also comprise a sterol, such as cholesterol (41). Combinations of saponins and cholesterols can be used to form unique particles called immunostimulating complexes (ISCOMs) (chapter 23 of ref. 74). ISCOMs typically also include a phospholipid such as phosphatidylethanolamine or phosphatidylcholine. Any known saponin can be used in ISCOMs. Preferably, the ISCOM includes one or more of QuilA, QHA & QHC. ISCOMs are further described in refs. 41-43. Optionally, the ISCOMS may be devoid of additional detergent (44). A review of the development of saponin based adjuvants can be found in refs. 45 & 46.
  • Fatty adjuvants (see in more detail below), including oil-in-water emulsions, modified natural lipid As derived from enterobacterial lipopolysaccharides, phospholipid compounds (such as the synthetic phospholipid dimer, E6020) and the like.
  • Bacterial ADP-ribosylating toxins (e.g., theE. coliheat labile enterotoxin “LT”, cholera toxin “CT”, or pertussis toxin “PT”) and detoxified derivatives thereof, such as the mutant toxins known as LT-K63 and LT-R72 (47). The use of detoxified ADP-ribosylating toxins as mucosal adjuvants is described in ref. 48 and as parenteral adjuvants in ref. 49.
  • Bioadhesives and mucoadhesives, such as esterified hyaluronic acid microspheres (50) or chitosan and its derivatives (51).
  • Microparticles (i.e., a particle of ˜100 nm to ˜150 nm in diameter, more preferably ˜200 nm to ˜30 nm in diameter, or ˜500 nm to ˜10 nm in diameter) formed from materials that are biodegradable and non-toxic (e.g., a poly(α-hydroxy acid), a polyhydroxybutyric acid, a polyorthoester, a polyanhydride, a polycaprolactone, and the like), with poly(lactide-co-glycolide) being preferred, optionally treated to have a negatively-charged surface (e.g., with SDS) or a positively-charged surface (e.g., with a cationic detergent, such as CTAB).
  • Liposomes (Chapters 13 & 14 of ref. 74). Examples of liposome formulations suitable for use as adjuvants are described in refs. 52-54.
  • Polyoxyethylene ethers and polyoxyethylene esters (55). Such formulations further include polyoxyethylene sorbitan ester surfactants in combination with an octoxynol (56) as well as polyoxyethylene alkyl ethers or ester surfactants in combination with at least one additional non-ionic surfactant such as an octoxynol (57). Preferred polyoxyethylene ethers are selected from the following group: polyoxyethylene-9-lauryl ether (laureth 9), polyoxyethylene-9-steoryl ether, polyoxytheylene-8-steoryl ether, polyoxyethylene-4-lauryl ether, polyoxyethylene-35-lauryl ether, and polyoxyethylene-23-lauryl ether.
  • Muramyl peptides, such as N-acetylmuramyl-L-threonyl-D-isoglutamine (“thr-MDP”), N-acetyl-normuramyl-L-alanyl-D-isoglutamine (nor-MDP), N-acetylglucsaminyl-N-acetylmuramyl-L-Al-D-isoglu-L-Ala-dipalmitoxy propylamide (“DTP-DPP”, or “Theramide™), N-acetylmuramyl-L-alanyl-D-isoglutaminyl-L-alanine-2-(1′-2′ dip almitoyl-s n-glycero-3-hydroxypho sphoryloxy)-ethyl amine (“MTP-PE”).
  • An outer membrane protein proteosome preparation prepared from a first Gram-negative bacterium in combination with a liposaccharide preparation derived from a second Gram-negative bacterium, wherein the outer membrane protein proteosome and liposaccharide preparations form a stable non-covalent adjuvant complex. Such complexes include “IVX-908”, a complex comprised ofNeisseria meningitidisouter membrane and lipopolysaccharides.
  • A polyoxidonium polymer (58, 59) or other N-oxidized polyethylene-piperazine derivative.
  • Methyl inosine 5′-monophosphate (“MIMP”) (60).
  • A polyhydroxlated pyrrolizidine compound (61), such as one having formula:
    • where R is selected from the group comprising hydrogen, straight or branched, unsubstituted or substituted, saturated or unsaturated acyl, alkyl (e.g., cycloalkyl), alkenyl, alkynyl and aryl groups, or a pharmaceutically acceptable salt or derivative thereof. Examples include, but are not limited to: casuarine, casuarine-6-α-D-glucopyranose, 3-epi-casuarine, 7-epi-casuarine, 3,7-diepi-casuarine, and the like
    • A CD1d ligand, such as an α-glycosylceramide (62-69) (e.g., α-galactosylceramide), phytosphingosine-containing α-glycosylceramides, OCH, KRN7000 [(2S,3S,4R)-1-O-(α-D-galactopyranosyl)-2-(N-hexacosanoylamino)-1,3,4-octadecanetriol], CRONY-101, 3″-O-sulfo-galactosylceramide, etc.
  • A gamma inulin (70) or derivative thereof, such as algammulin.
  • Virosomes and virus-like particles (VLPs). These structures generally contain one or more proteins from a virus optionally combined or formulated with a phospholipid. They are generally non-pathogenic, non-replicating and generally do not contain any of the native viral genome. The viral proteins may be recombinantly produced or isolated from whole viruses. These viral proteins suitable for use in virosomes or VLPs include proteins derived from influenza virus (such as HA or NA), Hepatitis B virus (such as core or capsid proteins), Hepatitis E virus, measles virus, Sindbis virus, Rotavirus, Foot-and-Mouth Disease virus, Retrovirus, Norwalk virus, human Papilloma virus, HIV, RNA-phages, QB-phage (such as coat proteins), GA-phage, fr-phage, AP205 phage, and Ty (such as retrotransposon Ty protein p1).
• These and other adjuvant-active substances are discussed in more detail in references 74 & 75.
• Compositions may include two, three, four or more adjuvants. For example, compositions of the invention may advantageously include both an oil-in-water emulsion and a cytokine-inducing agent, or both a mineral-containing composition and a cytokine-inducing agent, or two oil-in-water emulsion adjuvants, or two benzonaphthyridine compounds, etc.
• Antigens and adjuvants in a composition will typically be in admixture.
Oil Emulsion Adjuvants
• Oil emulsion compositions suitable for use as adjuvants in the invention include squalene-water emulsions, such as MF59 (5% Squalene, 0.5% Tween 80, and 0.5% Span 85, formulated into submicron particles using a microfluidizer). Complete Freund's adjuvant (CFA) and incomplete Freund's adjuvant (IFA) may also be used.
• Various oil-in-water emulsions are known, and they typically include at least one oil and at least one surfactant, with the oil(s) and surfactant(s) being biodegradable (metabolizable) and biocompatible. The oil droplets in the emulsion are generally less than 5 μm in diameter, and may even have a sub-micron diameter, with these small sizes being achieved with a microfluidizer to provide stable emulsions. Droplets with a size less than 220 nm are preferred as they can be subjected to filter sterilization.
• The invention can be used with oils such as those from an animal (such as fish) or vegetable source. Sources for vegetable oils include nuts, seeds and grains. Peanut oil, soybean oil, coconut oil, and olive oil, the most commonly available, exemplify the nut oils. Jojoba oil can be used, e.g., obtained from the jojoba bean. Seed oils include safflower oil, cottonseed oil, sunflower seed oil, sesame seed oil and the like. In the grain group, corn oil is the most readily available, but the oil of other cereal grains such as wheat, oats, rye, rice, teff, triticale and the like may also be used. 6-10 carbon fatty acid esters of glycerol and 1,2-propanediol, while not occurring naturally in seed oils, may be prepared by hydrolysis, separation and esterification of the appropriate materials starting from the nut and seed oils. Fats and oils from mammalian milk are metabolizable and may therefore be used in the practice of this invention. The procedures for separation, purification, saponification and other means necessary for obtaining pure oils from animal sources are well known in the art. Most fish contain metabolizable oils which may be readily recovered. For example, cod liver oil, shark liver oils, and whale oil such as spermaceti exemplify several of the fish oils which may be used herein. A number of branched chain oils are synthesized biochemically in 5-carbon isoprene units and are generally referred to as terpenoids. Shark liver oil contains a branched, unsaturated terpenoid known as squalene, 2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene, which is particularly preferred herein. Squalane, the saturated analog to squalene, is also preferred oil. Fish oils, including squalene and squalane, are readily available from commercial sources or may be obtained by methods known in the art. Other preferred oils are the tocopherols (see below). Mixtures of oils can be used.
• Surfactants can be classified by their ‘HLB’ (hydrophile/lipophile balance). Preferred surfactants of the invention have a HLB of at least 10, preferably at least 15, and more preferably at least 16. The invention can be used with surfactants including, but not limited to: the polyoxyethylene sorbitan esters surfactants (commonly referred to as the Tweens), especiallypolysorbate 20 andpolysorbate 80; copolymers of ethylene oxide (E0), propylene oxide (PO), and/or butylene oxide (BO), sold under the DOWFAX (TM) tradename, such as linear EO/PO block copolymers; octoxynols, which can vary in the number of repeating ethoxy (oxy-1,2-ethanediyl) groups, with octoxynol-9 (Triton X-100, or t-octylphenoxypolyethoxyethanol) being of particular interest; (octylphenoxy)polyethoxyethanol (IGEPAL CA-630/NP-40); phospholipids such as phosphatidylcholine (lecithin); nonylphenol ethoxylates, such as the TERGITOL (TM) NP series; polyoxyethylene fatty ethers derived from lauryl, cetyl, stearyl and oleyl alcohols (known as Brij surfactants), such as triethyleneglycol monolauryl ether (Brij 30); and sorbitan esters (commonly known as the SPANs), such as sorbitan trioleate (Span 85) and sorbitan monolaurate. Non-ionic surfactants are preferred. Preferred surfactants for including in the emulsion are TWEEN 80 (TM) (polyoxyethylene sorbitan monooleate), Span 85 (sorbitan trioleate), lecithin and Triton X-100.
• Mixtures of surfactants can be used e.g., TWEEN 80 (TM)/Span 85 mixtures. A combination of a polyoxyethylene sorbitan ester such as polyoxyethylene sorbitan monooleate (TWEEN 80 (TM)) and an octoxynol such as t-octylphenoxypolyethoxyethanol (Triton X-100) is also suitable. Another useful combination compriseslaureth 9 plus a polyoxyethylene sorbitan ester and/or an octoxynol.
• Preferred amounts of surfactants (% by weight) are: polyoxyethylene sorbitan esters (such as TWEEN 80 (TM)) 0.01 to 1%, in particular about 0.1%; octyl- or nonylphenoxy polyoxyethanols (such as Triton X-100, or other detergents in the Triton series) 0.001 to 0.1%, in particular 0.005 to 0.02%; polyoxyethylene ethers (such as laureth 9) 0.1 to 20%, preferably 0.1 to 10% and in particular 0.1 to 1% or about 0.5%.
• Specific oil-in-water emulsion adjuvants useful with the invention include, but are not limited to:
• • A submicron emulsion of squalene, TWEEN 80 (TM), and Span 85. The composition of the emulsion by volume can be about 5% squalene, about 0.5% polysorbate 80 and about 0.5% Span 85. In weight terms, these ratios become 4.3% squalene, 0.5% polysorbate 80 and 0.48% Span 85. This adjuvant is known as ‘MF59’ (71-73), as described in more detail inChapter 10 of ref. 74 andchapter 12 of ref. 75. The MF59 emulsion advantageously includes citrate ions, e.g., 10 mM sodium citrate buffer.
  • An emulsion of squalene, a tocopherol, and TWEEN 80 (TM). The emulsion may include phosphate buffered saline. It may also include Span 85 (e.g., at 1%) and/or lecithin. These emulsions may have from 2 to 10% squalene, from 2 to 10% tocopherol and from 0.3 to 3% TWEEN 80 (TM), and the weight ratio of squalene:tocopherol is preferably <1 as this provides a more stable emulsion. Squalene and TWEEN 80 (TM) may be present volume ratio of about 5:2. One such emulsion can be made by dissolving TWEEN 80 (TM) in PBS to give a 2% solution, then mixing 90 ml of this solution with a mixture of (5 g of DL-α-tocopherol and 5 ml squalene), then microfluidizing the mixture. The resulting emulsion may have submicron oil droplets, e.g., with an average diameter of between 100 and 250 nm, preferably about 180 nm
  • An emulsion of squalene, a tocopherol, and a Triton detergent (e.g., Triton X-100). The emulsion may also include a 3d-MPL (see below). The emulsion may contain a phosphate buffer.
  • An emulsion comprising a polysorbate (e.g., polysorbate 80), a Triton detergent (e.g., Triton X-100) and a tocopherol (e.g., an α-tocopherol succinate). The emulsion may include these three components at a mass ratio of about 75:11:10 (e.g., 750 μg/ml polysorbate 80, 110 μg/ml Triton X-100 and 100 μg/ml α-tocopherol succinate), and these concentrations should include any contribution of these components from antigens. The emulsion may also include squalene. The emulsion may also include a 3d-MPL (see below). The aqueous phase may contain a phosphate buffer.
  • An emulsion of squalane,polysorbate 80 and poloxamer 401 (“PLURONIC (TM) L121”). The emulsion can be formulated in phosphate buffered saline, pH 7.4. This emulsion is a useful delivery vehicle for muramyl dipeptides, and has been used with threonyl-MDP in the “SAF-1” adjuvant (76) (0.05-1% Thr-MDP, 5% squalane, 2.5% Pluronic L121 and 0.2% polysorbate 80). It can also be used without the Thr-MDP, as in the “AF” adjuvant (77) (5% squalane, 1.25% Pluronic L121 and 0.2% polysorbate 80). Microfluidization is preferred.
  • An emulsion comprising squalene, an aqueous solvent, a polyoxyethylene alkyl ether hydrophilic nonionic surfactant (e.g. polyoxyethylene (12) cetostearyl ether) and a hydrophobic nonionic surfactant (e.g. a sorbitan ester or mannide ester, such as sorbitan monoleate or ‘Span 80’). The emulsion is preferably thermoreversible and/or has at least 90% of the oil droplets (by volume) with a size less than 200 nm. The emulsion may also include one or more of: alditol; a cryoprotective agent (e.g. a sugar, such as dodecylmaltoside and/or sucrose); and/or an alkylpolyglycoside. Such emulsions may be lyophilized
  • An emulsion having from 0.5-50% of an oil, 0.1-10% of a phospholipid, and 0.05-5% of a non-ionic surfactant. As described in reference 78, preferred phospholipid components are phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, phosphatidylglycerol, phosphatidic acid, sphingomyelin and cardiolipin. Submicron droplet sizes are advantageous.
  • A submicron oil-in-water emulsion of a non-metabolizable oil (such as light mineral oil) and at least one surfactant (such as lecithin, TWEEN 80 (TM) or Span 80). Additives may be included, such as QuilA saponin, cholesterol, a saponin-lipophile conjugate (such as GPI-0100, described in reference 79, produced by addition of aliphatic amine to desacylsaponin via the carboxyl group of glucuronic acid), dimethyldioctadecylammonium bromide and/or N,N-dioctadecyl-N,N-bis(2-hydroxyethyl)propanediamine.
  • An emulsion comprising a mineral oil, a non-ionic lipophilic ethoxylated fatty alcohol, and a non-ionic hydrophilic surfactant (e.g. an ethoxylated fatty alcohol and/or polyoxyethylene-polyoxypropylene block copolymer).
  • An emulsion comprising a mineral oil, a non-ionic hydrophilic ethoxylated fatty alcohol, and a non-ionic lipophilic surfactant (e.g. an ethoxylated fatty alcohol and/or polyoxyethylene-polyoxypropylene block copolymer).
  • An emulsion in which a saponin (e.g., QuilA or QS21) and a sterol (e.g., a cholesterol) are associated as helical micelles (80).
  • The emulsions may be mixed with antigen extemporaneously, at the time of delivery. Thus the adjuvant and antigen may be kept separately in a packaged or distributed vaccine, ready for final formulation at the time of use. The antigen will generally be in an aqueous form, such that the vaccine is finally prepared by mixing two liquids. The volume ratio of the two liquids for mixing can vary (e.g., between 5:1 and 1:5) but is generally about 1:1.
Cytokine-Inducing Agents
• Cytokine-inducing agents for inclusion in compositions of the invention are able, when administered to a patient, to elicit the immune system to release cytokines, including interferons and interleukins. Preferred agents can elicit the release of one or more of: interferon-γ; interleukin-1; interleukin-2; interleukin-12; TNF-α; TNF-β; and GM-CSF. Preferred agents elicit the release of cytokines associated with a Th1-type immune response, e.g., interferon-γ, TNF-α, interleukin-2. Stimulation of both interferon-γ and interleukin-2 is preferred.
• As a result of receiving a composition of the invention, therefore, a patient will have T cells that, when stimulated with a RSV F protein, will release the desired cytokine(s) in an antigen-specific manner. For example, T cells purified from their blood will release γ-interferon when exposed in vitro to F protein. Methods for measuring such responses in peripheral blood mononuclear cells (PBMC) are known in the art, and include ELISA, ELISPOT, flow-cytometry and real-time PCR. For example, reference 81 reports a study in which antigen-specific T cell-mediated immune responses against tetanus toxoid, specifically γ-interferon responses, were monitored, and found that ELISPOT was the most sensitive method to discriminate antigen-specific TT-induced responses from spontaneous responses, but that intracytoplasmic cytokine detection by flow cytometry was the most efficient method to detect re-stimulating effects.
• Suitable cytokine-inducing agents include, but are not limited to:
• • An immunostimulatory oligonucleotide, such as one containing a CpG motif (a dinucleotide sequence containing an unmethylated cytosine linked by a phosphate bond to a guanosine), or a double-stranded RNA, or an oligonucleotide containing a palindromic sequence, or an oligonucleotide containing a poly(dG) sequence.
  • 3-O-deacylated monophosphoryl lipid A (‘3dMPL’, also known as ‘MPL (TM)’) (82-85).
  • An imidazoquinoline compound, such as IMIQUIMOD (TM) (“R-837”) (86, 87), RESIQUIMOD (TM) (“R-848”) (88), and their analogs; and salts thereof (e.g., the hydrochloride salts). Further details about immunostimulatory imidazoquinolines can be found in references 89 to 93.
  • A benzonaphthyridine compound, such as: (a) a compound having the formula:
  • wherein:
    • R⁴is selected from H, halogen, —C(O)OR⁷, —C(O)R⁷, —C(O)N(R¹¹R¹²), —N(R¹¹R¹²), —N(R⁹)₂, —NHN(R⁹)₂, —SR⁷, —(CH₂)_nOR⁷, —(CH₂)_nR⁷, -LR⁸, -LR¹⁰, —OLR⁸, —OLR¹⁰, C₁-C₆alkyl, C₁-C₆heteroalkyl, C₁-C₆haloalkyl, C₂-C₈alkene, C₂-C₈alkyne, C₁-C₆alkoxy, C₁-C₆haloalkoxy, aryl, heteroaryl, C₃-C₈cycloalkyl, and C₃-C₈heterocycloalkyl, wherein the C₁-C₆alkyl, C₁-C₆heteroalkyl, C₁-C₆haloalkyl, C₂-C₈alkene, C₂-C₈alkyne, C₁-C₆alkoxy, C₁-C₆haloalkoxy, aryl, heteroaryl, C₃-C₈cycloalkyl, and C₃-C₈heterocycloalkyl groups of R⁴are each optionally substituted with 1 to 3 substituents independently selected from halogen, —CN, —NO₂, —R⁷, —OR⁸, —C(O)R⁸, —OC(O)R⁸, —C(O)OR⁸, —N(R⁹)₂, —P(O)(OR⁸)₂, —OP(O)(OR⁸)₂, —P(O)(OR¹⁰)₂, —OP(O)(OR¹⁰)₂, —C(O)N(R⁹)₂, —S(O)₂R⁸, —S(O)R⁸, —S(O)₂N(R⁹)₂, and —NR⁹S(O)₂R⁸;
    • each L is independently selected from a bond, —(O(CH₂)_m)_r, C₁-C₆alkyl, C₂-C₆alkenylene and C₂-C₆alkynylene, wherein the C₁-C₆alkyl, C₂-C₆alkenylene and C₂-C₆alkynylene of L are each optionally substituted with 1 to 4 substituents independently selected from halogen, —R⁸, —OR⁸, —N(R⁹)₂, —P(O)(OR⁸)₂, —OP(O)(OR⁸)₂, —P(O)(OR¹⁰)₂, and —OP(O)(OR¹⁰)₂;
    • R⁷is selected from H, C₁-C₆alkyl, aryl, heteroaryl, C₃-C₈cycloalkyl, C₁-C₆heteroalkyl, C₁-C₆haloalkyl, C₂-C₈alkene, C₂-C₈alkyne, C₁-C₆alkoxy, C₁-C₆haloalkoxy, and C₃-C₈heterocycloalkyl, wherein the C₁-C₆alkyl, aryl, heteroaryl, C₃-C₈cycloalkyl, C₁-C₆heteroalkyl, C₁-C₆haloalkyl, C₂-C₈alkene, C₂-C₈alkyne, C₁-C₆alkoxy, C₁-C₆haloalkoxy, and C₃-C₈heterocycloalkyl groups of R⁷are each optionally substituted with 1 to 3 R¹³groups;
    • Each R⁸is independently selected From H, —CH(R¹⁰)₂, C₁-C₈alkyl, C₂-C₈alkene, C₂-C₈alkyne, C₁-C₆haloalkyl, C₁-C₆alkoxy, C₁-C₆heteroalkyl, C₃-C₈cycloalkyl, C₂-C₈heterocycloalkyl, C₁-C₆hydroxyalkyl and C₁-C₆haloalkoxy, wherein the C₁-C₈alkyl, C₂-C₈alkene, C₂-C₈alkyne, C₁-C₆heteroalkyl, C₁-C₆haloalkyl, C₁-C₆alkoxy, C₃-C₈cycloalkyl, C₂-C₈heterocycloalkyl, C₁-C₆hydroxyalkyl and C₁-C₆haloalkoxy groups of R⁸are each optionally substituted with 1 to 3 substituents independently selected from —CN, R¹¹, OR¹¹, —SR¹¹, C(O)R¹¹, —OC(O)R¹¹, —C(O)N(R⁹)₂, —C(O)OR¹¹, —NR⁹C(O)_R¹¹, —NR⁹R¹⁰, —NR¹¹R¹², —N(R⁹)₂, —OR⁹, —OR¹⁰, —C(O)NR¹¹R¹², —C(O)NR¹¹OH, —S(O)₂R¹¹, —S(O)R¹¹, —S(O)₂NR¹¹R¹², —NR¹¹S(O)²R¹¹, —P(O)(OR¹¹)₂, and —OP(O)(OR¹¹)₂;
    • each R⁹is independently selected from H, —C(O)R⁸, —C(O)OR⁸, —C(O)R¹⁰, —C(O)OR¹⁰, —S(O)₂R¹⁰, —C₁-C₆alkyl, C₁-C₆heteroalkyl and C₃-C₆cycloalkyl, or each R⁹is independently a C₁-C₆alkyl that together with N they are attached to form a C₃-C₈heterocycloalkyl, wherein the C₃-C₈heterocycloalkyl ring optionally contains an additional heteroatom selected from N, O and S, and wherein the C₁-C₆alkyl, C₁-C₆heteroalkyl, C₃-C₆cycloalkyl, or C₃-C₈heterocycloalkyl groups of R⁹are each optionally substituted with 1 to 3 substituents independently selected from —CN, R¹¹, —OR¹¹, —SR¹¹, —C(O)R¹¹, —OC(O)R¹¹, —C(O)OR¹¹, —NR¹¹R¹², -C(O)NR¹¹R¹², —C(O)NR¹¹OH, —S(O)₂R¹¹, —S(O)₂NR¹¹R¹², —NR¹¹S(O)²R¹¹, —P(O)(OR¹¹)₂, and —OP(O)(OR¹¹)₂;
  • each R¹⁰is independently selected from aryl, C₃-C₈cycloalkyl, C₃-C₈heterocycloalkyl and heteroaryl, wherein the aryl, C₃-C₈cycloalkyl, C₃-C₈heterocycloalkyl and heteroaryl groups are optionally substituted with 1 to 3 substituents selected from halogen, —R⁸, —OR⁸, -LR⁹, -LOR⁹, —N(R⁹)₂, —NR⁹C(O)R⁸, —NR⁹CO₂R⁸, —CO₂R⁸, —C(O)R⁸and —C(O)N(R⁹)₂;
  • R¹¹and R¹²are independently selected from H, C₁-C₆alkyl, C₁-C₆heteroalkyl, C₁-C₆haloalkyl, aryl, heteroaryl, C₃-C₈cycloalkyl, and C₃-C₈heterocycloalkyl, wherein the C₁-C₆alkyl, C₁-C₆heteroalkyl, C₁-C₆haloalkyl, aryl, heteroaryl, C₃-C₈cycloalkyl, and C₃-C₈heterocycloalkyl groups of R¹¹and R¹²are each optionally substituted with 1 to 3 substituents independently selected from halogen, —CN, R⁸, —OR⁸, —C(O)R⁸,⁻OC(O)R⁸, —C(O)OR⁸, —N(R⁹)₂, —NR⁸C(O)R⁸, —NR⁸C(O)OR⁸, —C(O)N(R⁹)₂, C₃-C₈heterocycloalkyl, —S(O)₂R⁸, —S(O)₂N(R⁹)₂, —NR⁹S(O)₂R⁸, C₁-C₆haloalkyl and C₁-C₆haloalkoxy;
    • or R¹¹and R¹²are each independently C₁-C₆alkyl and taken together with the N atom to which they are attached form an optionally substituted C₃-C₈heterocycloalkyl ring optionally containing an additional heteroatom selected from N, O and S;
    • each R¹³is independently selected from halogen, —CN, -LR⁹, -LOR⁹, —OLR⁹, -LR¹⁰, -LOR¹⁰, —OLR¹⁰, -LR⁸, -LOR^E, —OLR⁸, -LSR⁸, -LSR¹⁰, -LC(O)R⁸, —OLC(O)R⁸, -LC(O)OR⁸, -LC(O)R¹⁰, -LOC(O)OR⁸, -LC(O)NR⁹R¹¹, -LC(O)NR⁹R⁸, -LN(R⁹)₂, -LNR⁹R⁸, -LNR⁹R¹⁰, -LC(O)N(R⁹)₂, -LS(O)₂R⁸, -LS(O)R⁸, -LC(O)NR⁸OH, -LNR⁹C(O)R⁸, -LNR⁹C(O)OR⁸, -LS(O)₂N(R⁹)₂, —OLS(O)₂N(R⁹)₂, -LNR⁹S(O)₂R⁸, -LC(O)NR⁹LN(R⁹)₂, -LP(O)(OR⁸)₂, -LOP(O)(OR⁸)₂, -LP(O)(OR¹⁰)₂and) —OLP(O)(OR¹⁰)₂;
    • each R^Ais independently selected from —R⁸, —R⁷, —OR⁷, —OR⁸, —R¹⁰, —OR¹⁰, —SR⁸, —NO₂, —CN, —N(R⁹)₂, —NR⁹C(O)R⁸, —NR⁹C(S)R⁸, —NR⁹C(O)N(R⁹)₂, —NR⁹C(S)N(R⁹)₂, —NR⁹CO₂R⁸, —NR⁹NR⁹C(O)R⁸, —NR⁹NR⁹C(O)N(R⁹)₂, —NR⁹NR⁹CO₂R⁸, —C(O)C(O)R⁸, —C(O)CH₂C(O)R⁸, —CO₂R⁸, —(CH₂)_nCO₂R⁸, —C(O)R⁸, —C(S)R⁸, —C(O)N(R⁹)₂, —C(S)N(R⁹)₂, —OC(O)N(R⁹)₂, —OC(O)R⁸, —C(O)N(OR⁸)R⁸, —C(NOR⁸)R⁸, —S(O)₂R⁸, —S(O)₃R⁸, —SO₂N(R⁹)₂, —S(O)R⁸, —NR⁹SO₂N(R⁹)₂, —NR⁹SO₂R⁸, —P(O)(OR⁸)₂, —OP(O)(OR⁸)₂, —P(O)(OR¹⁰)₂, —OP(O)(OR¹⁰)₂, —N(OR⁸)R⁸, —CH═CHCO₂R⁸, —C(═NH)—N(R⁹)₂, and —(CH₂)_nNHC(O)R⁸; or two adjacent R^Asubstituents on Ring A form a 5-6 membered ring that contains up to two heteroatoms as ring members;
    • n is, independently at each occurrence, 0, 1, 2, 3, 4, 5, 6, 7 or 8;
    • each m is independently selected from 1, 2, 3, 4, 5 and 6, and
    • t is 1, 2, 3, 4, 5, 6, 7 or 8; (b) a compound having the formula:
  • wherein:
    • R⁴is selected from H, halogen, —C(O)OR⁷, —C(O)R⁷, —C(O)N(R¹¹R¹²), —N(R¹¹R¹²), —N(R⁹)₂, —NHN(R⁹)₂, —SR⁷, —(CH₂)_nOR⁷, —(CH₂)_nR⁷, -LR⁸, -LR¹⁰, —OLR⁸, —OLR¹⁰, C₁-C₆alkyl, C₁-C₆heteroalkyl, C₁-C₆haloalkyl, C₂-C₈alkene, C₂-C₈alkyne, C₁-C₆alkoxy, C₁-C₆haloalkoxy, aryl, heteroaryl, C₃-C₈cycloalkyl, and C₃-C₈heterocycloalkyl, wherein the C₁-C₆alkyl, C₁-C₆heteroalkyl, C₁-C₆haloalkyl, C₂-C₈alkene, C₂-C₈alkyne, C₁-C₆alkoxy, C₁-C₆haloalkoxy, aryl, heteroaryl, C₃-C₈cycloalkyl, and C₃-C₈heterocycloalkyl groups of R⁴are each optionally substituted with 1 to 3 substituents independently selected from halogen, —CN, —NO₂, —R⁷, —OR⁸, —C(O)R⁸, —OC(O)R⁸, —C(O)OR⁸, —N(R⁹)₂, —P(O)(OR⁸)₂, —OP(O)(OR⁸)₂, —P(O)(OR¹⁰)₂, —OP(O)(OR¹⁰)₂, —C(O)N(R⁹)₂, —S(O)₂R⁸, —S(O)R⁸, —S(O)₂N(R⁹)₂, and —NR⁹S(O)₂R⁸;
    • each L is independently selected from a bond, —(O(CH₂)_m)_r, C₁-C₆alkyl, C₂-C₆alkenylene and C₂-C₆alkynylene, wherein the C₁-C₆alkyl, C₂-C₆alkenylene and C₂-C₆alkynylene of L are each optionally substituted with 1 to 4 substituents independently selected from halogen, —R⁸, —OR⁸, —N(R⁹)₂, —P(O)(OR⁸)₂, —OP(O)(OR⁸)₂, —P(O)(OR¹⁰)₂, and —OP(O)(OR¹⁰)₂;
    • R⁷is selected from H, C₁-C₆alkyl, aryl, heteroaryl, C₃-C₈cycloalkyl, C₁-C₆heteroalkyl, C₁-C₆haloalkyl, C₂-C₈alkene, C₂-C₈alkyne, C₁-C₆alkoxy, C₁-C₆haloalkoxy, and C₃-C₈heterocycloalkyl, wherein the C₁-C₆alkyl, aryl, heteroaryl, C₃-C₈cycloalkyl, C₁-C₆heteroalkyl, C₁-C₆haloalkyl, C₂-C₈alkene, C₂-C₈alkyne, C₁-C₆alkoxy, C₁-C₆haloalkoxy, and C₃-C₈heterocycloalkyl groups of R⁷are each optionally substituted with 1 to 3 R¹³groups;
    • each R⁸is independently selected from H, —CH(R¹⁰)₂, C₁-C₈alkyl, C₂-C₈alkene, C₂-C₈alkyne, C₁-C₆haloalkyl, C₁-C₆alkoxy, C₁-C₆heteroalkyl, C₃-C₈cycloalkyl, C₂-C₈heterocycloalkyl, C₁-C₆hydroxyalkyl and C₁-C₆haloalkoxy, wherein the C₁-C₈alkyl, C₂-C₈alkene, C₂-C₈alkyne, C₁-C₆heteroalkyl, C₁-C₆haloalkyl, C₁-C₆alkoxy, C₃-C₈cycloalkyl, C₂-C₈heterocycloalkyl, C₁-C₆hydroxyalkyl and C₁-C₆haloalkoxy groups of R⁸are each optionally substituted with 1 to 3 substituents independently selected from —CN, R¹¹, —OR¹¹, —SR¹¹, —C(O)R¹¹, —OC(O)R¹¹, —C(O)N(R⁹)₂, —C(O)OR¹¹, —NR⁹C(O)R¹¹, —NR⁹R¹⁰, —NR¹¹R¹², —N(R⁹)₂, —OR⁹, —OR¹⁰, —C(O)NR¹¹R¹², —C(O)NR¹¹OH, —S(O)₂R¹¹, —S(O)R¹¹, —S(O)₂NR¹¹R¹², —NR¹¹S(O)₂R¹¹, —P(O)(OR¹¹)₂, and —OP(O)(OR¹¹)₂;
    • each R⁹is independently selected from H, —C(O)R⁸, —C(O)OR⁸, —C(O)R¹⁰, —C(O)OR¹⁰, —S(O)₂R¹⁰, —C₁-C₆alkyl, C₁-C₆heteroalkyl and C₃-C₆cycloalkyl, or each R⁹is independently a C₁-C₆alkyl that together with N they are attached to form a C₃-C₈heterocycloalkyl, wherein the C₃-C₈heterocycloalkyl ring optionally contains an additional heteroatom selected from N, O and S, and wherein the C₁-C₆alkyl, C₁-C₆heteroalkyl, C₃-C₆cycloalkyl, or C₃-C₈heterocycloalkyl groups of R⁹are each optionally substituted with 1 to 3 substituents independently selected from —CN, R¹¹, —OR¹¹, —SR¹¹, —C(O)R¹¹, —OC(O)R¹¹, —C(O)OR¹¹, —NR¹¹R¹², —C(O)NR¹¹R¹², —C(O)NR¹¹OH, —S(O)₂R¹¹, —S(O)R¹¹, —S(O)₂NR¹¹R¹², —NR¹¹S(O))₂R¹¹, —P(O)(OR¹¹)₂, and —OP(O)(OR¹¹)₂;
    • each R¹⁰is independently selected from aryl, C₃-C₈cycloalkyl, C₃-C₈heterocycloalkyl and heteroaryl, wherein the aryl, C₃-C₈cycloalkyl, C₃-C₈heterocycloalkyl and heteroaryl groups are optionally substituted with 1 to 3 substituents selected from halogen, —R⁸, —OR⁸, -LR⁹, -LOR⁹, —N(R⁹)₂, —NR⁹C(O)R⁸, —NR⁹CO₂R⁸, —CO₂R⁸, —C(O)R⁸and —C(O)N(R⁹)₂;
    • R¹¹and R¹²are independently selected from H, C₁-C₆alkyl, C₁-C₆heteroalkyl, C₁-C₆haloalkyl, aryl, heteroaryl, C₃-C₈cycloalkyl, and C₃-C₈heterocycloalkyl, wherein the C₁-C₆alkyl, C₁-C₆heteroalkyl, C₁-C₆haloalkyl, aryl, heteroaryl, C₃-C₈cycloalkyl, and C₃-C₈heterocycloalkyl groups of R¹¹and R¹²are each optionally substituted with 1 to 3 substituents independently selected from halogen, —CN, R⁸, —OR⁸, —C(O)R⁸,⁻OC(O)R⁸, —C(O)OR⁸, —N(R⁹)₂, —NR⁸C(O)R⁸, —NR⁸C(O)OR⁸, —C(O)N(R⁹)₂, C₃-C₈heterocycloalkyl, —S(O)₂R⁸, —S(O)₂N(R⁹)₂, —NR⁹S(O)₂R⁸, C₁-C₆haloalkyl and C₁-C₆haloalkoxy;
    • or R¹¹and R¹²are each independently C₁-C₆alkyl and taken together with the N atom to which they are attached form an optionally substituted C₃-C₈heterocycloalkyl ring optionally containing an additional heteroatom selected from N, O and S;
    • each R¹³is independently selected from halogen, —CN, -LR⁹, -LOR⁹, —OLR⁹, -LR¹⁰, -LOR¹⁰, —OLR¹⁰, -LR^B, -LOR^E, —OLR⁸, -LSR⁸, -LSR¹⁰, -LC(O)R⁸, —OLC(O)R⁸, -LC(O)OR⁸, -LC(O)R¹⁰, -LOC(O)OR⁸, -LC(O)NR⁹R¹¹, -LC(O)NR⁹R⁸, -LN(R⁹)₂, -LNR⁹R⁸, -LNR⁹R¹⁰, -LC(O)N(R⁹)₂, -LS(O)₂R⁸, -LS(O)R⁸, -LC(O)NR⁸OH, -LNR⁹C(O)R⁸, -LNR⁹C(O)OR⁸, LS(O)₂N(R⁹)₂, —OLS(O)₂N(R⁹)₂, -LNR⁹S(O)₂R⁸, -LC(O)NR⁹LN(R⁹)₂, -LP(O)(OR⁸)₂, -LOP(O)(OR⁸)₂, -LP(O)(OR¹⁰)₂and -OLP(O)(OR¹⁰)₂;
    • each R^Ais independently selected from —R⁸, —R⁷, —OR⁷, —OR⁸, —R¹⁰, —OR¹⁰, —SR⁸, —NO₂, —CN, —N(R⁹)₂, —NR⁹C(O)R⁸, —NR⁹C(S)R⁸, —NR⁹C(O)N(R⁹)₂, —NR⁹C(S)N(R⁹)₂, —NR⁹CO₂R⁸, —NR⁹NR⁹C(O)R⁸, —NR⁹NR⁹C(O)N(R⁹)₂, —NR⁹NR⁹CO₂R⁸, —C(O)C(O)R⁸, —C(O)CH₂C(O)R⁸, —CO₂R⁸, —(CH₂)_nCO₂R⁸, —C(O)R⁸, —C(S)R⁸, —C(O)N(R⁹)₂, —C(S)N(R⁹)₂, —OC(O)N(R⁹)₂, —OC(O)R⁸, —C(O)N(OR⁸)R⁸, —C(NOR⁸)R⁸, —S(O)₂R⁸, —S(O)₃R⁸, —SO₂N(R⁹)₂, —S(O)R⁸, —NR⁹SO₂N(R⁹)₂, —NR⁹SO₂R⁸, —P(O)(OR⁸)₂, —OP(O)(OR⁸)₂, —P(O)(OR¹⁰)₂, —OP(O)(OR¹⁰)₂, —N(OR⁸)R⁸, —CH═CHCO₂R⁸, —C(═NH)—N(R⁹)₂, and —(CH₂)_nNHC(O)R⁸;
  • n is, independently at each occurrence, 0, 1, 2, 3, 4, 5, 6, 7 or 8;
  • each m is independently selected from 1, 2, 3, 4, 5 and 6, and
  • t is 1, 2, 3, 4, 5, 6, 7 or 8; or (c) a pharmaceutically acceptable salt of any of (a) or (b).
• Other benzonaphthyridine compounds, and methods of making benzonaphthyridine compounds, are described in WO 2009/111337. A benzonaphthyridine compound, or a salt thereof, can be used on its own, or in combination with one or more further compounds. For example, a benzonaphthyridine compound can be used in combination with an oil-in-water emulsion or a mineral-containing composition. In a particular embodiment, a benzonaphthyridine compound is used in combination with an oil-in-water emulsion (e.g. a squalene-water emulsion, such as MF59) or a mineral-containing composition (e.g., a mineral said such as an aluminum salt or a calcium salt).
• • A thiosemicarbazone compound, such as those disclosed in reference 94. Methods of formulating, manufacturing, and screening for active compounds are also described in reference 94. The thiosemicarbazones are particularly effective in the stimulation of human peripheral blood mononuclear cells for the production of cytokines, such as TNF-α.
  • A tryptanthrin compound, such as those disclosed in reference 95. Methods of formulating, manufacturing, and screening for active compounds are also described in reference 95. The thiosemicarbazones are particularly effective in the stimulation of human peripheral blood mononuclear cells for the production of cytokines, such as TNF-α.
  • A nucleoside analog, such as: (a) Isatorabine (ANA-245; 7-thia-8-oxoguanosine):
  • and prodrugs thereof; (b) ANA975; (c) ANA-025-1; (d) ANA380; (e) the compounds disclosed in references 96 to 98; (f) a compound having the formula:
    • wherein:
      • R₁and R₂are each independently H, halo, —NR_aR_b, —OH, C_1-6alkoxy, substituted C_1-6alkoxy, heterocyclyl, substituted heterocyclyl, C_6-10aryl, substituted C_6-10aryl, C_1-6alkyl, or substituted C_1-6alkyl;
      • R₃is absent, H, C_1-6alkyl, substituted C_1-6alkyl, C_6-10aryl, substituted C_6-10aryl, heterocyclyl, or substituted heterocyclyl;
      • R₄and R₅are each independently H, halo, heterocyclyl, substituted heterocyclyl, —C(O)—R_d, C_1-6alkyl, substituted C_1-6alkyl, or bound together to form a 5 membered ring as in R_4-5:
        • R_4-5
      • the binding being achieved at the bonds indicated by a
      • X₁and X₂are each independently N, C, O, or S;
      • R₈is H, halo, —OH, C_1-6alkyl, C_2-6alkenyl, C_2-6alkynyl, —OH, —NR_aR_b, —(CH₂)_n—O—R_c, —O—(C_1-6alkyl), —S(O)_pR_e, or —C(O)—R_d;
      • R₉is H, C_1-6alkyl, substituted C_1-6alkyl, heterocyclyl, substituted heterocyclyl or R_9a, wherein R_9ais:
        • R_9a
      • the binding being achieved at the bond indicated by a
      • R₁₀and R¹¹are each independently H, halo, C_1-6alkoxy, substituted C_1-6alkoxy, —NR_aR_b, or —OH;
      • each R_aand R_bis independently H, C_1-6alkyl, substituted C_1-6alkyl, —C(O)R_d, C_6-10aryl;
      • each R_cis independently H, phosphate, diphosphate, triphosphate, C_1-6alkyl, or substituted C_1-6alkyl;
      • each R_dis independently H, halo, C_1-6alkyl, substituted C_1-6alkyl, C_1-6alkoxy, substituted C_1-6alkoxy, —NH₂, —NH(C_1-6alkyl), —NH(substituted C_1-6alkyl), —N(C_1-6alkyl)₂, —N(substituted C_1-6alkyl)₂, C_6-10aryl, or heterocyclyl;
      • each R_eis independently H, C_1-6alkyl, substituted C_1-6alkyl, C_6-10aryl, substituted C_6-10aryl, heterocyclyl, or substituted heterocyclyl;
      • each R_fis independently H, C_1-6alkyl, substituted C_1-6alkyl, —C(O)R_d, phosphate, diphosphate, or triphosphate;
      • each n is independently 0, 1, 2, or 3;
      • each p is independently 0, 1, or 2; or
    • or (g) a pharmaceutically acceptable salt of any of (a) to (f), a tautomer of any of (a) to (f), or a pharmaceutically acceptable salt of the tautomer.
  • Loxoribine (7-allyl-8-oxoguanosine) (99).
  • Compounds disclosed inreference 100, including: Acylpiperazine compounds, Indoledione compounds, Tetrahydraisoquinoline (THIQ) compounds, Benzocyclodione compounds, Aminoazavinyl compounds, Aminobenzimidazole quinolinone (ABIQ) compounds (101, 102), Hydrapthalamide compounds, Benzophenone compounds, Isoxazole compounds, Sterol compounds, Quinazilinone compounds, Pyrrole compounds (103), Anthraquinone compounds, Quinoxaline compounds, Triazine compounds, Pyrazalopyrimidine compounds, and Benzazole compounds (104).
  • Compounds disclosed in reference 105.
  • An aminoalkyl glucosaminide phosphate derivative, such as R^cC-529 (106, 107).
  • A phosphazene, such as poly[di(carboxylatophenoxy)phosphazene] (“PCPP”) as described, for example, inreferences 108 and 109.
  • Small molecule immunopotentiators (SMIPs) such as:
• N2-methyl-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline-2,4-diamine
• N2,N2-dimethyl-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline-2,4-diamine
• N2-ethyl-N2-methyl-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline-2,4-diamine
• N2-methyl-1-(2-methylpropyl)-N2-propyl-1H-imidazo[4,5-c]quinoline-2,4-diamine
• 1-(2-methylpropyl)-N2-propyl-1H-imidazo[4,5-c]quinoline-2,4-diamine
• N2-butyl-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline-2,4-diamine
• N2-butyl-N2-methyl-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline-2,4-diamine
• N2-methyl-1-(2-methylpropyl)-N2-pentyl-1H-imidazo[4,5-c]quinoline-2,4-diamine
• N2-methyl-1-(2-methylpropyl)-N2-prop-2-enyl-1H-imidazo[4,5-c]quinoline-2,4-diamine
• 1-(2-methylpropyl)-2-[(phenylmethyl)thio]-1H-imidazo[4,5-c]quinolin-4-amine
• 1-(2-methylpropyl)-2-(propylthio)-1H-imidazo[4,5-c]quinolin-4-amine
• 2-[[4-amino-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-2-yl](methyl)amino]ethanol
• 2-[[4-amino-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-2-yl](methyl)amino]ethyl acetate
• 4-amino-1-(2-methylpropyl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one
• N2-butyl-1-(2-methylpropyl)-N4,N4-bis(phenylmethyl)-1H-imidazo[4,5-c]quinoline-2,4-diamine
• N2-butyl-N2-methyl-1-(2-methylpropyl)-N4,N4-bis(phenylmethyl)-1H-imidazo[4,5-c]quinoline-2,4-diamine
• N2-methyl-1-(2-methylpropyl)-N4,N4-bis(phenylmethyl)-1H-imidazo[4,5-c]quinoline-2,4-diamine
• N2,N2-dimethyl-1-(2-methylpropyl)-N4,N4-bis(phenylmethyl)-1H-imidazo[4,5-c]quinoline-2,4-diamine
• 1-[4-amino-2-[methyl(propyl)amino]-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol
• 1-[4-amino-2-(propylamino)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol
• N4,N4-dibenzyl-1-(2-methoxy-2-methylpropyl)-N2-propyl-1H-imidazo[4,5-c]quinoline-2,4-diamine.
• The cytokine-inducing agents for use in the present invention may be modulators and/or agonists of Toll-Like Receptors (TLR). For example, they may be agonists of one or more of the human TLR1, TLR2, TLR3, TLR4, TLR7, TLR8, and/or TLR9 proteins. Preferred agents are agonists of TLR4 (e.g., modified natural lipid As derived from enterobacterial lipopolysaccharides, phospholipid compounds, such as the synthetic phospholipid dimer, E6020), TLR7 (e.g., benzonaphthyridines, imidazoquinolines) and/or TLR9 (e.g., CpG oligonucleotides). These agents are useful for activating innate immunity pathways.
• The cytokine-inducing agent can be added to the composition at various stages during its production. For example, it may be within an antigen composition, and this mixture can then be added to an oil-in-water emulsion. As an alternative, it may be within an oil-in-water emulsion, in which case the agent can either be added to the emulsion components before emulsification, or it can be added to the emulsion after emulsification. Similarly, the agent may be coacervated within the emulsion droplets. The location and distribution of the cytokine-inducing agent within the final composition will depend on its hydrophilic/lipophilic properties, e.g., the agent can be located in the aqueous phase, in the oil phase, and/or at the oil-water interface.
• The cytokine-inducing agent can be conjugated to a separate agent, such as an antigen (e.g., CRM197). A general review of conjugation techniques for small molecules is provided in ref. 110. As an alternative, the adjuvants may be non-covalently associated with additional agents, such as by way of hydrophobic or ionic interactions.
• Preferred cytokine-inducing agents are (a) benzonapthridine compounds; (b) immunostimulatory oligonucleotides and (c) 3dMPL.
• Immunostimulatory oligonucleotides can include nucleotide modifications/analogs such as phosphorothioate modifications and can be double-stranded or (except for RNA) single-stranded.References 111, 112, and 113 disclose possible analog substitutions, e.g., replacement of guanosine with 2′-deoxy-7-deazaguanosine. The adjuvant effect of CpG oligonucleotides is further discussed in refs. 114 to 119. A CpG sequence may be directed to TLR9, such as the motif GTCGTT or TTCGTT (120). The CpG sequence may be specific for inducing a Th1 immune response, such as a CpG-A ODN (oligodeoxynucleotide), or it may be more specific for inducing a B cell response, such a CpG-B ODN. CpG-A and CpG-B ODNs are discussed in refs. 121-123. Preferably, the CpG is a CpG-A ODN. Preferably, the CpG oligonucleotide is constructed so that the 5′ end is accessible for receptor recognition. Optionally, two CpG oligonucleotide sequences may be attached at their 3′ ends to form “immunomers”. See, for example, references 120 & 124-126. A useful CpG adjuvant is CpG7909, also known as PROMUNE (TM) (Coley Pharmaceutical Group, Inc.).
• As an alternative, or in addition, to using CpG sequences, TpG sequences can be used (127). These oligonucleotides may be free from unmethylated CpG motifs.
• The immunostimulatory oligonucleotide may be pyrimidine-rich. For example, it may comprise more than one consecutive thymidine nucleotide (e.g., TTTT, as disclosed in ref. 127), and/or it may have a nucleotide composition with >25% thymidine (e.g., >35%, >40%, >50%, >60%, >80%, etc.). For example, it may comprise more than one consecutive cytosine nucleotide (e.g., CCCC, as disclosed in ref. 127), and/or it may have a nucleotide composition with >25% cytosine (e.g., >35%, >40%, >50%, >60%, >80%, etc.). These oligonucleotides may be free from unmethylated CpG motifs.
• Immunostimulatory oligonucleotides will typically comprise at least 20 nucleotides. They may comprise fewer than 100 nucleotides.
• 3dMPL (also known as 3 de-O-acylated monophosphoryl lipid A or 3-O-desacyl-4′-monophosphoryl lipid A) is an adjuvant in whichposition 3 of the reducing end glucosamine in monophosphoryl lipid A has been de-acylated. 3dMPL has been prepared from a heptoseless mutant ofSalmonella minnesota, and is chemically similar to lipid A but lacks an acid-labile phosphoryl group and a base-labile acyl group. It activates cells of the monocyte/macrophage lineage and stimulates release of several cytokines, including IL-1, IL-12, TNF-α and GM-CSF (see also ref. 128). Preparation of 3dMPL was originally described in reference 129.
• 3dMPL can take the form of a mixture of related molecules, varying by their acylation (e.g., having 3, 4, 5 or 6 acyl chains, which may be of different lengths). The two glucosamine (also known as 2-deoxy-2-amino-glucose) monosaccharides are N-acylated at their 2-position carbons (i.e., atpositions 2 and 2′), and there is also O-acylation at the 3′ position. The group attached tocarbon 2 has formula —NH—CO—CH₂—CR¹R^1′. The group attached tocarbon 2′ has formula —NH—CO—CH₂—CR²R^2′. The group attached tocarbon 3′ has formula —O—CO—CH₂—CR³R^3′. A representative structure is:
• Groups R′, R²and R³are each independently —(CH₂)_n—CH₃. The value of n is preferably between 8 and 16, more preferably between 9 and 12, and is most preferably 10.
• Groups R^1′, R^2′ and R^3′ can each independently be: (a) —H; (b) —OH; or (c) —O-CO—R⁴,where R⁴is either —H or —(CH₂)_m—CH₃, wherein the value of m is preferably between 8 and 16, and is more preferably 10, 12 or 14. At the 2 position, m is preferably 14. At the 2′ position, m is preferably 10. At the 3′ position, m is preferably 12. Groups R^1′, R^2′ and R^3′ are thus preferably —O-acyl groups from dodecanoic acid, tetradecanoic acid or hexadecanoic acid.
• When all of R^1′, R^2′ and R^3′ are —H then the 3dMPL has only 3 acyl chains (one on each ofpositions 2, 2′ and 3′). When only two of R^1′, R^2′ and R^3′ are —H then the 3dMPL can have 4 acyl chains. When only one of R^1′, R^2′ and R^3′ is —H then the 3dMPL can have 5 acyl chains. When none of R^1′, R^2′ and R^3′ is —H then the 3dMPL can have 6 acyl chains. The 3dMPL adjuvant used according to the invention can be a mixture of these forms, with from 3 to 6 acyl chains, but it is preferred to include 3dMPL with 6 acyl chains in the mixture, and in particular to ensure that the hexaacyl chain form makes up at least 10% by weight of the total 3dMPL e.g., >20%, >30%, >40%, >50% or more. 3dMPL with 6 acyl chains has been found to be the most adjuvant-active form.
• Thus the most preferred form of 3dMPL for inclusion in compositions of the invention has formula (IV), shown below.
• Where 3dMPL is used in the form of a mixture then references to amounts or concentrations of 3dMPL in compositions of the invention refer to the combined 3dMPL species in the mixture.
• In aqueous conditions, 3dMPL can form micellar aggregates or particles with different sizes e.g., with a diameter <150 nm or >500 nm. Either or both of these can be used with the invention, and the better particles can be selected by routine assay. Smaller particles (e.g., small enough to give a clear aqueous suspension of 3dMPL) are preferred for use according to the invention because of their superior activity (130). Preferred particles have a mean diameter less than 220 nm, more preferably less than 200 nm or less than 150 nm or less than 120 nm, and can even have a mean diameter less than 100 nm. In most cases, however, the mean diameter will not be lower than 50 nm These particles are small enough to be suitable for filter sterilization. Particle diameter can be assessed by the routine technique of dynamic light scattering, which reveals a mean particle diameter. Where a particle is said to have a diameter of x nm, there will generally be a distribution of particles about this mean, but at least 50% by number (e.g., >60%, >70%, >80%, >90%, or more) of the particles will have a diameter within the range x+25%.
• 3dMPL can advantageously be used in combination with an oil-in-water emulsion. Substantially all of the 3dMPL may be located in the aqueous phase of the emulsion.
• The 3dMPL can be used on its own, or in combination with one or more further compounds. For example, it is known to use 3dMPL in combination with the QS21 saponin (131) (including in an oil-in-water emulsion (132)), with an immunostimulatory oligonucleotide, with both QS21 and an immunostimulatory oligonucleotide, with aluminum phosphate (133), with aluminum hydroxide (134), or with both aluminum phosphate and aluminum hydroxide.
• Formula (IV)
Fatty Adjuvants
• Fatty adjuvants that can be used with the invention include the oil-in-water emulsions described above, and also include, for example:
• • A phospholipid compound of formula I, II or III, or a salt thereof:

• I	II	III

• • as defined in reference 135, such as ‘ER 803058’, ‘ER 803732’, ‘ER 804053’, ER 804058′, ‘ER 804059’, ‘ER 804442’, ‘ER 804680’, ‘ER 804764’, ER 803022 or ‘ER 804057’ e.g.:
    • ER804057
    • ER-803022.
  • ER804057 is also called E6020. A phospholipid compound of formula I, II or III, or a salt thereof, can be used on its own, or in combination with one or more further compounds. For example, a compound of formula I, II or III, can be used in combination with an oil-in-water emulsion or a mineral-containing composition. In a particular embodiment, E6020 is used in combination with an oil-in-water emulsion (e.g. a squalene-water emulsion, such as MF59) or a mineral-containing composition (e.g., a mineral sald such as an aluminum salt or a calcium salt).
  • Derivatives of lipid A fromEscherichia colisuch as OM-174 (described in refs. 136 & 137).
  • A formulation of a cationic lipid and a (usually neutral) co-lipid, such as aminopropyl-dimethyl-myristoleyloxy-propanaminium bromide-diphytanoylphosphatidyl-ethanolamine (“VAXFECTIN (TM)”) or aminopropyl-dimethyl-bis-dodecyloxy-propanaminium bromide-dioleoylphosphatidyl-ethanolamine (“GAP-DLRIE:DOPE”). Formulations containing (+)-N-(3-aminopropyl)-N,N-dimethyl-2,3-bis(syn-9-tetradeceneyloxy)-1-propanaminium salts are preferred (138).
  • 3-O-deacylated monophosphoryl lipid A (see above).
  • Compounds containing lipids linked to a phosphate-containing acyclic backbone, such as the TLR4 antagonist E5564 (139, 140):
    • Lipopeptides (i.e., compounds comprising one or more fatty acid residues and two or more amino acid residues), such as lipopeptides based on glycerylcysteine. Specific examples of such peptides include compounds of the following formula
      in which each of R¹and R²represents a saturated or unsaturated, aliphatic or mixed aliphatic-cycloaliphatic hydrocarbon radical having from 8 to 30, preferably 11 to 21, carbon atoms that is optionally also substituted by oxygen functions, R³represents hydrogen or the radical R₁—CO—O—CH₂— in which R¹has the same meaning as above, and X represents an amino acid bonded by a peptide linkage and having a free, esterified or amidated carboxy group, or an amino acid sequence of from 2 to 10 amino acids of which the terminal carboxy group is in free, esterified or amidated form. In certain embodiments, the amino acid sequence comprises a D-amino acid, for example, D-glutamic acid (D-Glu) or D-gamma-carboxy-glutamic acid (D-Gla).
• Bacterial lipopeptides generally recognize TLR2, without requiring TLR6 to participate. (TLRs operate cooperatively to provide specific recognition of various triggers, and TLR2 plus TLR6 together recognize peptidoglycans, while TLR2 recognizes lipopeptides without TLR6.) These are sometimes classified as natural lipopeptides and synthetic lipopeptides. Synthetic lipopeptides tend to behave similarly, and are primarily recognized by TLR2.
• Lipopeptides suitable for use as adjuvants include compounds have the formula:
• where the chiral center labeled * and the one labeled *** are both in the R configuration; the chiral center labeled ** is either in the R or S configuration;
• each R^1aand R^1bis independently an aliphatic or cycloaliphatic-aliphatic hydrocarbon group having 7-21 carbon atoms, optionally substituted by oxygen functions, or one of R^1aand R^1b, but not both, is H;
• R²is an aliphatic or cycloaliphatic hydrocarbon group having 1-21 carbon atoms and optionally substituted by oxygen functions;
• n is 0 or 1;
• As represents either —O-Kw-CO— or —NH-Kw-CO—, where Kw is an aliphatic hydrocarbon group having 1-12 carbon atoms;
• As¹is a D- or L-alpha-amino acid;
• Z¹and Z²each independently represent —OH or the N-terminal radical of a D- or L-alpha amino acid of an amino-(lower alkane)-sulfonic acid or of a peptide having up to 6 amino acids selected from the D- and L-alpha aminocarboxylic acids and amino-lower alkyl-sulfonic acids; and
• Z³is H or —CO—Z⁴, wher Z⁴is —OH or the N-terminal radical of a D- or L-alpha amino acid of an amino-(lower alkane)-sulfonic acid or of a peptide having up to 6 amino acids selected from the D and L-alpha aminocarboxylic acids and amino-lower alkyl-sulfonic acids; or an ester or amide formed from the carboxylic acid of such compounds. Suitable amides include —NH₂and NH(lower alkyl), and suitable esters include C1-C4 alkyl esters. (lower alkyl or lower alkane, as used herein, refers to C₁-C₆straight chain or branched alkyls).
• Such compounds are described in more detail in U.S. Pat. No. 4,666,886. In one particular embodiment, the lipopeptide has the formula:
• Another example of a lipopeptide species is called LP40, and is an agonist of TLR2. Akdis, et al.,Eur. J. Immunology,33: 2717-26 (2003).
• These are related to a known class of lipopeptides fromE. coli, referred to as murein lipoproteins. Certain partial degradation products of those proteins called murein lipopetides are described in Hantke, et al.,Eur. J. Biochem.,34: 284-296 (1973). These comprise a peptide linked to N-acetyl muramic acid and are thus related to Muramyl peptides, which are described in Baschang, et al.,Tetrahedron,45(20): 6331-6360 (1989).
Aluminum Salt Adjuvants
• The adjuvants known as “aluminum hydroxide” and “aluminum phosphate” may be used. These names are conventional, but are used for convenience only, as neither is a precise description of the actual chemical compound which is present (e.g., seechapter 9 of reference 74). The invention can use any of the “hydroxide” or “phosphate” adjuvants that are in general use as adjuvants.
• The adjuvants known as “aluminum hydroxide” are typically aluminum oxyhydroxide salts, which are usually at least partially crystalline. Aluminum oxyhydroxide, which can be represented by the formula AlO(OH), can be distinguished from other aluminum compounds, such as aluminum hydroxide Al(OH)₃, by infrared (IR) spectroscopy, in particular by the presence of an adsorption band at 1070 cm⁻¹and a strong shoulder at 3090-3100 cm⁻¹(chapter 9 of ref. 74). The degree of crystallinity of an aluminum hydroxide adjuvant is reflected by the width of the diffraction band at half height (WHH), with poorly-crystalline particles showing greater line broadening due to smaller crystallite sizes. The surface area increases as WHH increases, and adjuvants with higher WHH values have been seen to have greater capacity for antigen adsorption. A fibrous morphology (e.g., as seen in transmission electron micrographs) is typical for aluminum hydroxide adjuvants. The pI of aluminum hydroxide adjuvants is typically about 11, i.e., the adjuvant itself has a positive surface charge at physiological pH. Adsorptive capacities of between 1.8-2.6 mg protein per mg Al⁺⁺⁺ at pH 7.4 have been reported for aluminum hydroxide adjuvants.
• The adjuvants known as “aluminum phosphate” are typically aluminum hydroxyphosphates, often also containing a small amount of sulfate (i.e., aluminum hydroxyphosphate sulfate). They may be obtained by precipitation, and the reaction conditions and concentrations during precipitation influence the degree of substitution of phosphate for hydroxyl in the salt. Hydroxyphosphates generally have a PO₄/Al molar ratio between 0.3 and 1.2. Hydroxyphosphates can be distinguished from strict AlPO₄by the presence of hydroxyl groups. For example, an IR spectrum band at 3164 cm⁻¹(e.g., when heated to 200° C.) indicates the presence of structural hydroxyls (ch.9 of ref. 74)
• The PO₄/Al³⁺ molar ratio of an aluminum phosphate adjuvant will generally be between 0.3 and 1.2, preferably between 0.8 and 1.2, and more preferably 0.95+0.1. The aluminum phosphate will generally be amorphous, particularly for hydroxyphosphate salts. A typical adjuvant is amorphous aluminum hydroxyphosphate with PO₄/All molar ratio between 0.84 and 0.92, included at 0.6 mg Al³⁺/ml. The aluminum phosphate will generally be particulate (e.g., plate-like morphology as seen in transmission electron micrographs). Typical diameters of the particles are in the range 0.5-20 μm (e.g., about 5-10 μm) after any antigen adsorption. Adsorptive capacities of between 0.7-1.5 mg protein per mg Al⁺⁺⁺ at pH 7.4 have been reported for aluminum phosphate adjuvants.
• The point of zero charge (PZC) of aluminum phosphate is inversely related to the degree of substitution of phosphate for hydroxyl, and this degree of substitution can vary depending on reaction conditions and concentration of reactants used for preparing the salt by precipitation. PZC is also altered by changing the concentration of free phosphate ions in solution (more phosphate=more acidic PZC) or by adding a buffer such as a histidine buffer (makes PZC more basic). Aluminum phosphates used according to the invention will generally have a PZC of between 4.0 and 7.0, more preferably between 5.0 and 6.5, e.g., about 5.7.
• Suspensions of aluminum salts used to prepare compositions of the invention may contain a buffer (e.g., a phosphate or a histidine or a Tris buffer), but this is not always necessary. The suspensions are preferably sterile and pyrogen-free. A suspension may include free aqueous phosphate ions e.g., present at a concentration between 1.0 and 20 mM, preferably between 5 and 15 mM, and more preferably about 10 mM. The suspensions may also comprise sodium chloride.
• The invention can use a mixture of both an aluminum hydroxide and an aluminum phosphate. In this case there may be more aluminum phosphate than hydroxide e.g., a weight ratio of at least 2:1 e.g., >5:1, >6:1, >7:1, >8:1, >9:1, etc.
• The concentration of Al⁺⁺⁺ in a composition for administration to a patient is preferably less than 10 mg/ml e.g., <5 mg/ml, <4 mg/ml, <3 mg/ml, <2 mg/ml, <1 mg/ml, etc. A preferred range is between 0.3 and 1 mg/ml. A maximum of 0.85 mg/dose is preferred.
• As well as including one or more aluminum salt adjuvants, the adjuvant component may include one or more further adjuvant or immunostimulating agents. Such additional components include, but are not limited to: a benzonaphthyridine compound, a 3-O-deacylated monophosphoryl lipid A adjuvant (‘3d-MPL’); and/or an oil-in-water emulsion. 3d-MPL has also been referred to as 3 de-O-acylated monophosphoryl lipid A or as 3-O-desacyl-4′-monophosphoryl lipid A. The name indicates thatposition 3 of the reducing end glucosamine in monophosphoryl lipid A is de-acylated. It has been prepared from a heptoseless mutant ofS. minnesota, and is chemically similar to lipid A but lacks an acid-labile phosphoryl group and a base-labile acyl group. It activates cells of the monocyte/macrophage lineage and stimulates release of several cytokines, including IL-1, IL-12, TNF-α and GM-CSF. Preparation of 3d-MPL was originally described in reference 129, and the product has been manufactured and sold by Corixa Corporation under the name MPL (TM). Further details can be found in refs 82 to 85.
• The use of an aluminum hydroxide and/or aluminum phosphate adjuvant is useful, particularly in children, and antigens are generally adsorbed to these salts. Squalene-in-water emulsions are also preferred, particularly in the elderly. Useful adjuvant combinations include combinations of Th1 and Th2 adjuvants such as CpG and alum, or resiquimod and alum. A combination of aluminum phosphate and 3dMPL may be used. Other combinations that may be used include: alum and a benzonapthridine compound or a SMIP, a squalene-in-water emulsion (such as MF59) and a benzonapthridine compound or a SMIP, and E6020 and a squalene-in-water emulsion, such as MF59) or alum.
• The compositions of the invention may elicit both a cell mediated immune response as well as a humoral immune response.
• Two types of T cells, CD4 and CD8 cells, are generally thought necessary to initiate and/or enhance cell mediated immunity and humoral immunity. CD8 T cells can express a CD8 co-receptor and are commonly referred to as Cytotoxic T lymphocytes (CTLs). CD8 T cells are able to recognized or interact with antigens displayed onMHC Class 1 molecules.
• CD4 T cells can express a CD4 co-receptor and are commonly referred to as T helper cells. CD4 T cells are able to recognize antigenic peptides bound to MHC class II molecules. Upon interaction with a MHC class II molecule, the CD4 cells can secrete factors such as cytokines. These secreted cytokines can activate B cells, cytotoxic T cells, macrophages, and other cells that participate in an immune response. Helper T cells or CD4+ cells can be further divided into two functionally distinct subsets: TH1 phenotype and TH2 phenotypes which differ in their cytokine and effector function.
• Activated TH1 cells enhance cellular immunity (including an increase in antigen-specific CTL production) and are therefore of particular value in responding to intracellular infections. Activated TH1 cells may secrete one or more of IL-2, IFN-γ, and TNF-β. A TH1 immune response may result in local inflammatory reactions by activating macrophages, NK (natural killer) cells, and CD8 cytotoxic T cells (CTLs). A TH1 immune response may also act to expand the immune response by stimulating growth of B and T cells with IL-12. TH1 stimulated B cells may secrete IgG2a.
• Activated TH2 cells enhance antibody production and are therefore of value in responding to extracellular infections. Activated TH2 cells may secrete one or more of IL-4, IL-5, IL-6, and IL-10. A TH2 immune response may result in the production of IgG1, IgE, IgA and memory B cells for future protection.
• An enhanced immune response may include one or more of an enhanced TH1 immune response and a TH2 immune response.
• A TH1 immune response may include one or more of an increase in CTLs, an increase in one or more of the cytokines associated with a TH1 immune response (such as IL-2, IFN-γ, and TNF-β), an increase in activated macrophages, an increase in NK activity, or an increase in the production of IgG2a. Preferably, the enhanced TH1 immune response will include an increase in IgG2a production.
• A TH1 immune response may be elicited using a TH1 adjuvant. A TH1 adjuvant will generally elicit increased levels of IgG2a production relative to immunization of the antigen without adjuvant. TH1 adjuvants suitable for use in the invention may include for example saponin formulations, virosomes and virus like particles, non-toxic derivatives of enterobacterial lipopolysaccharide (LPS), immunostimulatory oligonucleotides. Immunostimulatory oligonucleotides, such as oligonucleotides containing a CpG motif, are preferred TH1 adjuvants for use in the invention.
• A TH2 immune response may include one or more of an increase in one or more of the cytokines associated with a TH2 immune response (such as IL-4, IL-5, IL-6 and IL-10), or an increase in the production of IgG1, IgE, IgA and memory B cells. Preferably, the enhanced TH2 immune response will include an increase in IgG1 production.
• A TH2 immune response may be elicited using a TH2 adjuvant. A TH2 adjuvant will generally elicit increased levels of IgG1 production relative to immunization of the antigen without adjuvant. TH2 adjuvants suitable for use in the invention include, for example, mineral containing compositions, oil-emulsions, and ADP-ribosylating toxins and detoxified derivatives thereof. Mineral containing compositions, such as aluminium salts are preferred TH2 adjuvants for use in the invention.
• A composition may include a combination of a TH1 adjuvant and a TH2 adjuvant. Preferably, such a composition elicits an enhanced TH1 and an enhanced TH2 response, i.e., an increase in the production of both IgG1 and IgG2a production relative to immunization without an adjuvant. Still more preferably, the composition comprising a combination of a TH1 and a TH2 adjuvant elicits an increased TH1 and/or an increased TH2 immune response relative to immunization with a single adjuvant (i.e., relative to immunization with a TH1 adjuvant alone or immunization with a TH2 adjuvant alone).
• The immune response may be one or both of a TH1 immune response and a TH2 response. Preferably, immune response provides for one or both of an enhanced TH1 response and an enhanced TH2 response.
• The enhanced immune response may be one or both of a systemic and a mucosal immune response. Preferably, the immune response provides for one or both of an enhanced systemic and an enhanced mucosal immune response. Preferably the mucosal immune response is a TH2 immune response. Preferably, the mucosal immune response includes an increase in the production of IgA.
• Methods of Treatment, and Administration
• Compositions of the invention are suitable for administration to mammals, and the invention provides a method of inducing an immune response in a mammal, comprising the step of administering a composition (e.g., an immunogenic composition) of the invention to the mammal. The compositions (e.g., an immunogenic composition) can be used to produce a vaccine formulation for immunizing a mammal. The mammal is typically a human, and the RSV F protein is typically a human RSV F protein. However, the mammal can be any other mammal that is susceptible to infection with RSV, such as a cow that can be infected with bovine RSV. For example, the immune response may be raised following administration of a purified RSV F protein, an alphavirus particle, or self-replicating RNA.
• The invention also provides the use of two or more pre-fusion chimerid proteins based on two or more different non-RSV (e.g., parainfluenza virus, metapneumovirus) F pre-fusion proteins (i.e., PIV5 and NDV) that each have the same RSV F neutralizing epitopes mutated on the protein surface. Thus, inoculation with one chimeric pre-fusion F, and a second inoculation with the second pre-fusion F may prime several antibodies, some to RSV and some to the template protein backbone. The second inoculation may bias boosting of only the shared RSV F neutralizing epitopes.
• The invention also provides a composition of the invention for use as a medicament, e.g., for use in immunizing a patient against RSV infection.
• The invention also provides the use of a polypeptide as described above in the manufacture of a medicament for raising an immune response in a patient.
• The immune response raised by these methods and uses will generally include an antibody response, preferably a protective antibody response. Methods for assessing antibody responses after RSV vaccination are well known in the art.
• Compositions of the invention can be administered in a number of suitable ways, such as intramuscular injection (e.g., into the arm or leg), subcutaneous injection, intranasal administration, oral administration, intradermal administration, transcutaneous administration, transdermal administration, and the like. The appropriate route of administration will be dependent upon the age, health and other characteristics of the mammal. A clinician will be able to determine an appropriate route of administration based on these and other factors.
• Immunogenic compositions, and vaccine formulations, may be used to treat both children and adults, including pregnant women. Thus a subject may be less than 1 year old, 1-5 years old, 5-15 years old, 15-55 years old, or at least 55 years old. Preferred subjects for receiving the vaccines are the elderly (e.g., >50 years old, >60 years old, and preferably >65 years), the young (e.g., <6 years old, such as 4-6 years old, <5 years old), and pregnant women. The vaccines are not suitable solely for these groups, however, and may be used more generally in a population.
• Treatment can be by a single dose schedule or a multiple dose schedule. Multiple doses may be used in a primary immunization schedule and/or in a booster immunization schedule. In a multiple dose schedule the various doses may be given by the same or different routes, e.g., a parenteral prime and mucosal boost, a mucosal prime and parenteral boost, etc. Administration of more than one dose (typically two doses) is particularly useful in immunologically naïve patients. Multiple doses will typically be administered at least 1 week apart (e.g., about 2 weeks, about 3 weeks, about 4 weeks, about 6 weeks, about 8 weeks, about 10 weeks, about 12 weeks, about 16 weeks, and the like).
• Vaccine formulations produced using a composition of the invention may be administered to patients at substantially the same time as (e.g., during the same medical consultation or visit to a healthcare professional or vaccination centre) other vaccines.
General
• The term “comprising” encompasses “including” as well as “consisting” and “consisting essentially of” e.g., a composition “comprising” X may consist exclusively of X or may include something additional e.g., X+Y.
• The word “substantially” does not exclude “completely” e.g., a composition which is “substantially free” from Y may be completely free from Y. Where necessary, the word “substantially” may be omitted from the definition of the invention.
• The term “about” in relation to a numerical value x means, for example, x±10%.
• Unless specifically stated, a process comprising a step of mixing two or more components does not require any specific order of mixing. Thus components can be mixed in any order. Where there are three components then two components can be combined with each other, and then the combination may be combined with the third component, etc.
• Where animal (and particularly bovine) materials are used in the culture of cells, they should be obtained from sources that are free from transmissible spongiform encaphalopathies (TSEs), and in particular free from bovine spongiform encephalopathy (BSE). Overall, it is preferred to culture cells in the total absence of animal-derived materials.
• Where a compound is administered to the body as part of a composition then that compound may alternatively be replaced by a suitable prodrug.
• Where a cell substrate is used for reassortment or reverse genetics procedures, it is preferably one that has been approved for use in human vaccine production e.g., as in Ph Eur general chapter 5.2.3.
• Identity between polypeptide sequences is preferably determined by the Smith-Waterman homology search algorithm as implemented in the MPSRCH program (Oxford Molecular), using an affine gap search with parameters gap open penalty=12 and gap extension penalty=1.

• TABLE 2
  Phospholipids

  DDPC

  	1,2-Didecanoyl-sn-Glycero-3-phosphatidylcholine
  DEPA
  	1,2-Dierucoyl-sn-Glycero-3-Phosphate
  DEPC
  	1,2-Erucoyl-sn-Glycero-3-phosphatidylcholine
  DEPE
  	1,2-Dierucoyl-sn-Glycero-3-phosphatidylethanolamine
  DEPG
  	1,2-Dierucoyl-sn-Glycero-3[Phosphatidyl-rac-(1-glycerol . . . )
  DLOPC	1,2-Linoleoyl-sn-Glycero-3-phosphatidylcholine
  DLPA
  	1,2-Dilauroyl-sn-Glycero-3-Phosphate
  DLPC
  	1,2-Dilauroyl-sn-Glycero-3-phosphatidylcholine
  DLPE
  	1,2-Dilauroyl-sn-Glycero-3-phosphatidylethanolamine
  DLPG
  	1,2-Dilauroyl-sn-Glycero-3[Phosphatidyl-rac-(1-glycerol . . . )
  DLPS	1,2-Dilauroyl-sn-Glycero-3-phosphatidylserine
  DMG
  	1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine
  DMPA
  	1,2-Dimyristoyl-sn-Glycero-3-Phosphate
  DMPC
  	1,2-Dimyristoyl-sn-Glycero-3-phosphatidylcholine
  DMPE
  	1,2-Dimyristoyl-sn-Glycero-3-phosphatidylethanolamine
  DMPG
  	1,2-Myristoyl-sn-Glycero-3[Phosphatidyl-rac-(1-glycerol . . . )
  DMPS	1,2-Dimyristoyl-sn-Glycero-3-phosphatidylserine
  DOPA
  	1,2-Dioleoyl-sn-Glycero-3-Phosphate
  DOPC
  	1,2-Dioleoyl-sn-Glycero-3-phosphatidylcholine
  DOPE
  	1,2-Dioleoyl-sn-Glycero-3-phosphatidylethanolamine
  DOPG
  	1,2-Dioleoyl-sn-Glycero-3[Phosphatidyl-rac-(1-glycerol . . . )
  DOPS	1,2-Dioleoyl-sn-Glycero-3-phosphatidylserine
  DPPA
  	1,2-Dipalmitoyl-sn-Glycero-3-Phosphate
  DPPC
  	1,2-Dipalmitoyl-sn-Glycero-3-phosphatidylcholine
  DPPE
  	1,2-Dipalmitoyl-sn-Glycero-3-phosphatidylethanolamine
  DPPG
  	1,2-Dipalmitoyl-sn-Glycero-3[Phosphatidyl-rac-(1-glycerol . . . )
  DPPS	1,2-Dipalmitoyl-sn-Glycero-3-phosphatidylserine
  DPyPE
  	1,2-diphytanoyl-sn-glycero-3-phosphoethanolamine
  DSPA
  	1,2-Distearoyl-sn-Glycero-3-Phosphate
  DSPC
  	1,2-Distearoyl-sn-Glycero-3-phosphatidylcholine
  DSPE
  	1,2-Diostearpyl-sn-Glycero-3-phosphatidylethanolamine
  DSPG
  	1,2-Distearoyl-sn-Glycero-3[Phosphatidyl-rac-(1-glycerol . . . )
  DSPS	1,2-Distearoyl-sn-Glycero-3-phosphatidylserine
  EPC	Egg-PC
  HEPC	Hydrogenated Egg PC
  HSPC	High purity Hydrogenated Soy PC
  HSPC	Hydrogenated Soy PC
  LYSOPC	MYRISTIC 1-Myristoyl-sn-Glycero-3-phosphatidylcholine
  LYSOPC	PALMITIC 1-Palmitoyl-sn-Glycero-3-phosphatidylcholine
  LYSOPC	STEARIC 1-Stearoyl-sn-Glycero-3-phosphatidylcholine
  Milk Sphingomyelin MPPC	1-Myristoyl,2-palmitoyl-sn-Glycero 3-phosphatidylcholine
  MSPC	1-Myristoyl,2-stearoyl-sn-Glycero-3-phosphatidylcholine
  PMPC	1-Palmitoyl,2-myristoyl-sn-Glycero-3-phosphatidylcholine
  POPC	1-Palmitoyl,2-oleoyl-sn-Glycero-3-phosphatidylcholine
  POPE	1-Palmitoyl-2-oleoyl-sn-Glycero-3-phosphatidylethanolamine
  POPG
  	1,2-Dioleoyl-sn-Glycero-3[Phosphatidyl-rac-(1-glycerol) . . . ]
  PSPC	1-Palmitoyl,2-stearoyl-sn-Glycero-3-phosphatidylcholine
  SMPC	1-Stearoyl,2-myristoyl-sn-Glycero-3-phosphatidylcholine
  SOPC	1-Stearoyl,2-oleoyl-sn-Glycero-3-phosphatidylcholine
  SPPC	1-Stearoyl,2-palmitoyl-sn-Glycero-3-phosphatidylcholine

EXEMPLIFICATION1. Post-Fusion Structure and Pre-Fusion Model
• Post-Fusion RSV F Structure
• A stable, non-aggregating soluble RSV F subunit antigen was prepared by deletion of the fusion peptide, transmembrane region, and cytoplasmic domain (FIG. 1). This engineered F was expressed efficiently and was readily purified. Electron microscopy of negatively stained specimens showed that it formed non-aggregated, homogeneous crutch-shaped molecules, consistent with post-fusion F trimers (FIG. 2A). This engineered F trimer was stable, and circular dichroism spectroscopy revealed no significant melting at temperatures up to 95° C. (FIGS. 2B and 2C).
• This RSV F protein was crystallized and its structure was determined by molecular replacement and three-fold non-crystallographic symmetry (NCS) averaging (Table 3 andFIG. 3). The structure does not include the p27 fragment (the peptide between the two furin sites that is lost upon cleavage), the fusion peptide, the transmembrane region, or the cytoplasmic domain (FIG. 4).

• TABLE 3
  Crystallographic data

  Data collection statistics
  Space Group	P	212121
  Cell dimensions (Å)	a = 87.930
  	b = 113.160
  	c = 311.370
  	α = β = γ = 90.00°
  Resolution limit (Å)	50-3.2
  Unique reflections	51,911
  Unique reflections†	40,398
  Redundancy	3.9 (3.7)¥
  Overall completeness (%)	99.4 (99.4)
  Overall completeness (%)†	77.0 (26.7)
  <I/σ>	12.2 (2.2)
  Rsym(%)	7.7 (71.0)
  Refinement Statistics††
  Polypeptide chains	3
  Protein atoms	10,398
  Residues in allowed regions of the Ramachandran	98.5
  plot (%)
  Residues in most favored regions of Ramachandran	83.5
  plot (%)
  RMSD bond lengths (Å)	0.021
  RMSD bond angles (deg)	2.053
  Mean B values (Å2)	15.71
  Resolution range (Å)	30-3.2
  Rwork(%)	23.1 (34.9)
  Rfree(%)	26.6 (40.2)
  ¥Values in parentheses refer to data in the highest resolution shell
  †Statistics for the data after anisotropic correction.
  ††Refinement values for the data after anisotropic correction.

• The overall architecture of post-fusion RSV F is shared with other post-fusion parainfluenza fusion proteins. The protein is composed of three tightly intertwined subunits, forming a globular head and an elongated stalk. Each subunit contains three domains, designated I, II, and III (FIGS. 4A-C). Domains I and II are at the top of the trimeric head and form a triangular crown. Domain III forms the base of the head. A long helix, HRA, extends from domain III and forms the trimeric coiled-coil in the center of the stalk. The HRB helix is tethered to domain II and reaches down to the head-distal end of the stalk, where it forms the outer coils of a six-helix bundle with the HRA interior coiled-coil. In full-length F, the hydrophobic fusion peptide (N-terminal to HRA) and the transmembrane region (C-terminal to HRB), would be juxtaposed at the bottom of the stalk and inserted into the target cell membrane.
• Domains I and II of RSV, parainfluenza virus 3 (PIV3), and parainfluenza virus 5 (PIV5) F proteins are structurally conserved (FIGS. 5A and 5B). The only significant difference is in the orientation of the sole helix of domain I (η3 of RSV F and α6 of PIV3 and PIV5 Fs) relative to their common β-sheets. In contrast, RSV F domain III has features that were not predicted from parainfluenza-based modeling (FIG. 6). When the four-stranded β-sheets of RSV F domain III and PIV3 F domain III are superimposed, key differences in the domains' helical regions are apparent. Helix HRA kinks at a more N-terminal position in RSV F than in PIV3 F, causing an approximately 60° difference in the rotation of the heads relative to the stalks (FIGS. 6A,6B,6D). Influenza hemagglutinins also vary in the orientations of their heads relative to their stalks, with 30°-50° differences in rotation between subtypes. (Ha, Y. et al.,Embo Journal21, 865-875 (2002)).
• The RSV F domain III helical bundle region contains an extra helix (a6), changing the orientation of the bundled helices relative to those in parainfluenza Fs (FIGS. 6A-C andFIG. 1). RSV F helices α5 and α6 are almost parallel and are exposed on the trimer surface; the equivalent to RSV F α6 helix in the PIV3 helical bundle (α5,FIG. 6C) is buried in the inter-subunit interface of the trimer. RSV F helices α5 and α6 form the epitope bound by the related neutralizing antibodies Palivizumab and Motavizumab. The structure of a complex between the Motavizumab Fab and a 24-residue RSV F peptide that includes α5 and α6 has been reported (McLellan, J. S. et al.NatStruct Mol Biol17, 248-250 (2010)). Comparison between this structure and the post-fusion RSV F structure revealed a close match between the α5-α6 helices (r.m.s.d.=0.52 Å;FIG. 7A). Superposition of the two structures based on these helices models a complex between Motavizumab and post-fusion RSV F (FIG. 7B). This model reveals no steric hindrance that would prevent Motavizumab (or, presumably, Palivizumab) from binding to post-fusion RSV F. Binding of Palivizumab to the post-fusion F ectodomain in solution using surface plasmon resonance (K_Dof 4.2×10⁻¹⁰M) was confirmed.
• Pre-fusion and post-fusion parainfluenza F structures reveal en bloc shifts of domains and large rearrangements of HRA and HRB. In domain III of the pre-fusion PIV5 F structure (the only reported pre-fusion parainfluenza F structure), HRA folds into three α-helices and two β-strands rather than the long post-fusion HRA helix (Yin, H. S., et al.Nature439, 38-44 (2006)). However, when pre-fusion and post-fusion conformations of individual parainfluenza F protein domains are compared, the non-rearranging parts superimpose well. Superimposing post-fusion RSV F domains on their pre-fusion PIV5 F counterparts did not result in major clashes and positions all the pairs of cysteines that form interdomain disulfide bonds in proximity (FIG. 8B).
• The resulting pre-fusion RSV F model reveals a feature not apparent from modeling pre-fusion RSV F domains based on the PIV5 pre-fusion domain structures (McLellan, J. S. et al.NatStruct Mol Biol17, 248-250 (2010)). The helices of the Motavizumab epitope are exposed on the surface of the pre-fusion RSV F trimer, as they are on post-fusion RSV F trimer (FIG. 9). In the current pre-fusion RSV F model, the loop connecting β4 and HRC (part of domain III) would hinder access of Palivizumab or Motavizumab to the epitope. However, the loop may have sufficient flexibility to adopt an alternative conformation that permits antibody binding (FIG. 9B).
• The antigenic structure of RSV F has been mapped by a variety of techniques (FIG. 1). The best documented epitope clusters are designated A and C (Beeler, J. A. & van Wyke Coelingh, K.J Virol63, 2941-2950 (1989)), and others have been proposed. The Motavizumab-peptide structure corroborated the location of site A, although it called into question the site's exposure on the RSF F trimer (McLellan, J. S. et al. Structural basis of respiratory syncytial virus neutralization by motavizumab.NatStruct Mol Biol17, 248-250 (2010)); a crystal structure of an RSV F peptide (residues 422-436) bound to the 101F neutralizing antibody corroborated the location of site C (McLellan, J. S. et al.J Virol84, 12236-12244 (2010)). The post-fusion structure of RSV F and the pre-fusion RSV F model indicate that sites A and C remain exposed and structurally similar in both conformations (FIGS. 8A and 8B). Superposition of the 101F-peptide complex on the RSV F pre-fusion model and post-fusion structure confirmed that 101F would not clash with F in either conformation (FIG. 10).
• Provided in the Appendix is the PDB file of the RSV F pre-fusion model based on the RSV F post-fusion structure and sequence/domain alignments to the PIV5 pre-fusion structure. The PDB file contains the atomic coordinates for the pre-fusion model, and can be used with suitable software for molecular visualization and analysis (e.g., Roger Sayle and E. James Milner-White. “RasMol: Biomolecular graphics for all”,Trends in Biochemical Sciences(TIBS), September 1995, Vol. 20, No. 9, p. 374) to display the model. Included in the model are the three subunit chains with the fusion peptide and HRA region folded as in PIV5, making significant contacts with DIII. HRB regions of the three subunits trimerize into the pre-fusion stalk and are associated with D1 and DII.
• 2. Destablizing the Post-Fusion 6-Helix Bundle Through Deletion of the HRB Helix
• An HRB deletion construct was designed to prevent formation of the post-fusion conformation. Two constructs have been designed to address this strategy. The first is a wild-type ectodomain lacking the HRB region (RSV F residues 1-483) call Del HRB:
• The sequence presented below contain a signal peptide and a HIS tag (GGSAGSGHHHHHH; SEQ ID NO:3). The pre-fusion RSV F protein of the invention can contain the amino acid sequences shown below, with or without the signal peptide and/or HIS tag.

• >RSV F delHRB HIS

  (SEQ ID NO: 28)

  MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRT

  GWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTELQLLMQST

  PATNNRARRELPRFMNYTLNNAKKTNVTLSKKRKRRFLGFLLGVGSAIAS

  GVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYID

  KQLLPIVNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTY

  MLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYV

  VQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVS

  FFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKT

  DVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTV

  SVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSGGSAGSGHHHHHH

• The above sequence has both furin cleavage sites unaltered, and was expected to be processed by the cell. In addition, the above sequence has the wild-type fusion peptide sequence. In previous experiments, when the RSV F ectodomain-based proteins were cleaved by the cell and contained fusion peptides, they formed soluble aggregates with cellular debris in the form of RSV F rosettes. If this construct remained in the pre-fusion conformation (due to the lack of the HRB helix thought to be required for post-fusion conformation) than the fusion peptide should be burried in the RSV F head domain and should not form rosette aggreagates. This construct was expressed, purified by affinity purification and evaluated by EM analysis (FIG. 12).
• It is clear both by its migration on an SEC column in the void volume, as well as from the EM micrograph that the construct formed rosettes similar to the rosettes formed by post-fusion RSV F proteins. This result was a surprise as it was hypothesized that the HRB is required to stabilize the HRA in its elongated helix formation (as it is observed that HRA peptides do not form trimers). Thus, we hypothesized that the fusion peptides, binding with one another or with cellular debris, are stabilizing the HRA helixes in their elongated, post-fusion formation.
• We have hypothesized that the post-fusion like phenotype of the DelHRB construct was due to stabilization of the HRA into elongated helices by binding of the fusion peptides to one another or cellular debris. To test this hypothesis we are generating the following construct (DelHRB fusion peptide deletion:below) which is similar to the DelHRB but has the fusion peptide deletion consistent with our post-fusion trimer. We will test by EM microscopy the phenotype of the contruct to see if it forms crutch-like structures similar to that of the post-fusion like phenotype observed in the DelHRB rosettes of if the construct forms pre-fusion head shapes, which are similar to the spherical shape of the lollipop phenotype published in the literature.
• The sequence presented below contain a signal peptide and a HIS tag (GGSAGSGHHHHHH; SEQ ID NO:3). The pre-fusion RSV F protein of the invention can contain the amino acid sequences shown below, with or without the signal peptide and/or HIS tag.

• >RSV F delHRB fusion peptide deletion HIS

  (SEQ ID NO: 10)

  MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRT

  GWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTELQLLMQST

  PATNNRARRELPRFMNYTLNNAKKTNVTLSKKRKRRSAIASGVAVSKVLH

  LEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDKQLLPIVNK

  QSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLS

  LINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVI

  DTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCK

  VQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITS

  LGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYV

  NKQEGKSLYVKGEPIINFYDPLVFPSGGSAGSGHHHHHH

• 3. Prefusion Stabilization with Intrachain Disulfide Bond Formation
• The RSV F model, based on the RSV F post-fusion structure and PIV5 pre-fusion structure, was used to engineer cysteine mutations intended to form disulfide bonds that stabilize RSV F in the pre-fusion conformation (FIG. 11). The intrachain disulfide bond constructs were expressed, and were secreted from the cell into the media and then cleaved from F0 to F1/F2 to various degrees (FIG. 14). RSV F T58C/V164C (expressed in mammalian cells) was found to express as a cleaved species which is secreted into the media. The material was purified by chelating purification and evaluated by the rosette/trimer HPLC-SEC assay using the Bio-Sil 250 SEC column with 2×PBS as mobile phase (FIG. 15). As this is a cleaved F containing a fusion peptide, it was expected that would be in the postfusion form and would form rosettes and migrate in the void volume similar to postfusion RSV F rosettes (FIG. 15A). If the cleaved F protein harboring a fusion peptide was folded in the prefusion form, one would expect the fusion peptide to be buried in the prefusion head region preventing rosette formation. Prefusion trimers should migrate in the included volume with a retention time similar to the RSV F postfusion trimer lacking the fusion peptide (FIG. 15B). RSV F HRA Disulfide T58C V164C was run on HPLC-SEC, and the majority of material migrated in the column void volume, indicating the material was aggregating or forming rosettes of postfusion F. A smaller portion of the protein migrated in the included volume with a retention time consistent with an F trimer, suggesting some material formed the desired stabilized prefusion F.
• The disulfide constructs were subsequently cloned into baculovirus expression vectors and three constructs (HRA disulfides N165C/V296C and K168C/V296C and HRB M396C/F483C) were expressed. K168C/V296C and M396C/F483C, which were cleaved when expressed in mammalian cells, were secreted by insect cells predominantly as an uncleaved species (as shown by anti-HIS western blot). Both constructs migrated in the void fraction, which was inconsistent with previous observations that uncleaved species run as monomers. The proteins may have aggregated by virtue of incorrect disulfide formation. Gel shift analysis using anti-HIS western (FIG. 16) suggested that intra-chain disulfide bonds were not formed. The pure material taken from the void fraction of the SEC was analyzed with SDS-PAGE and coomassie staining, and each protein was found to be approximately 50% cleaved (FIG. 16). A third disulfide construct was expressed and N165C/V296C was secreted predominantly as the desired cleaved product as judged by western blot (FIG. 16A).
• 4. NDV F Prefusion Structure for Further Development of the RSV-NDV Chimera Subunit
• A strategy for rescuing the RSV HRA prefusion epitopes was developed to generate an NDV F prefusion construct and mutate select residues of the HRA to those of RSV F. Initial attempts to replace the HRA of NDV with the HRA of RSV generated a construct which was not expressed/secreted from the cell. This indicated that the protein was misfolded. Further refinement of the residues of NDV F available for mutagenisis (i.e. those located on the protein surface) was required. A new construct, NDV F stabilized with a GCN trimerization domain (uncleaved) migrated as a trimer by SEC analysis. This was expected as this construct was shown to be a pre-fusion trimer by electron microscopy (Swanson et al, 2010).
• 5. EM Analysis of RSV F with HRB and Fusion Peptide Deletion Related to NDV Pre-Fusion Construct
• The HRB-deleted RSV F harboring the fusion-peptide was generated, and the protein was purified. The construct migrated in the void volume of the SEC column consistent with RSV F rosettes. The construct was evaluated by EM and shown to form rosettes similar to the postfusion RSV F (FIG. 18A). An RSV F protein with both the HRB and fusion peptide deleted (Del-HRB Del-FP) was generated, expressed and purified. RSV F with the HRB and fusion peptide deleted ran partially as a trimer on SEC (FIG. 18B). Gel analysis showed that RSV F del-HRB and Del-FP migrated both in the aggregation/rosette peak and trimer peak (FIG. 18C). For comparison, the uncleaved NDV pre-fusion construct had very little material in the void fraction (FIG. 18C). The RSV F Del-HRB Del-FP was collected from the trimer volume and evaluated by EM.
• Electron micrographs of the NDV pre-fusion construct showed predominately the spherical heads expected for pre-fusion F (FIG. 18D). A portion of the material seemed to be associated in rosette-like aggregates, which should not be permitted as the construct is uncleaved and pre-fusion. This amount of association may be due to aggregation by the HIS-tag, and may explain why the RSV Del-HRB Del-FP contained some aggregate/rosette even when the fusion peptide was not present. EM analysis of RSV F Del-HRB Del-FP showed that the material was heterogeneous (FIG. 18E). RSV F Del-HRB Del-FP formed rosette-like structures similar to NDV F, as well as post-fusion like “crutches” and pre-fusion like “spheres”.

• R057 delHRB delFP trunc 6H (fusion peptide deleted)

  (SEQ ID NO: 10)

  MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRT

  GWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTELQLLMQ

  STPATNNRARRELPRFMNYTLNNAKKTNVTLSKKRKRRSAIASGYAV

  SKVLHLEGEYNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDKQ

  LLPIVNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYML

  TNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVV

  QLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSV

  SFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMT

  SKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKG

  VDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSGGSAGSGHH

  HHHH**

  R105 delHRB delFP + linker trunk 6H (fusion

  peptide and linker deleted)

  (SEQ ID NO: 38)

  MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRT

  GWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTELQLLMQ

  STPATNNRARRELPRFMNYTLNNAKKTNVTLSKKRKRRSAIASGVAV

  SKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDKQ

  LLPIVNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYML

  TNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVV

  QLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSV

  SFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMT

  SKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKG

  VDTVSVGNTLYYVNKQEGGGSAGSGHHHHHH**

• 6. Design of RSV F Non-Native HRB Constructs
• A stable RSV prefusion F was generated by replacing the HRB region with either the HRB region of NDV (with or without an additional glycine linker: HRB2) or PIV5. Mammalian expression of the non-native HRB constructs showed that each of the constructs were expressed and secreted well (FIG. 19). Additionally, the band observed migrated consistent with the cleaved F1 species, suggesting that the proteins were properly processed. The constructs existed with or without fusion peptide (as indicated inFIG. 19).
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• The entire teachings of all documents cited herein are hereby incorporated herein by reference.

• APPENDIX
  (APPENDIX discloses SEQ ID NOS 29-32, 29-32 and 29-32, respectively, in order of appearance)

  HEADER ----	XX-XXX-9-xxxx
  COMPND ---

  SSBOND	1 CYS G 69 CYS G 212
  SSBOND	2 CYS G 313 CYS G 343
  SSBOND	3 CYS G 322 CYS G 333
  SSBOND	4 CYS G 358 CYS G 367
  SSBOND	5 CYS G 382 CYS G 393
  SSBOND	6 CYS G 416 CYS G 422

  LINKR	C1 NAG J 1535   ND2 ASN G 70   NAG-ASN
  LINKR	C1 NAG J 1545   ND2 ASN G 500   NAG-ASN
  LINKR	C1 NAG J 1525   ND2 ASN G 27   NAG-ASN

  SSBOND	7 CYS H 69 CYS H 212
  SSBOND	8 CYS H 313 CYS H 343
  SSBOND	9 CYS H 322 CYS H 333
  SSBOND	10 CYS H 358 CYS H 367
  SSBOND	11 CYS H 382 CYS H 393
  SSBOND	12 CYS H 416 CYS H 422

  LINKR	C1 NAG K 1535   ND2 ASN H 70   NAG-ASN
  LINKR	OD1 ASN H 500   C7 NAG K 1545   ASN-NAG
  LINKR	C1 NAG K 1545   ND2 ASN H 500   NAG-ASN
  LINKR	OD1 ASN H 27    O7 NAG K 1525   ASN-NAG1
  LINKR	C1 NAG K 1525   ND2 ASN H 27   NAG-ASN

  SSBOND	13 CYS I 69 CYS I 212
  SSBOND	14 CYS I 313 CYS I 343
  SSBOND	15 CYS I 322 CYS I 333
  SSBOND	16 CYS I 358 CYS I 367
  SSBOND	17 CYS I 382 CYS I 393
  SSBOND	18 CYS I 416 CYS I 422

  LINKR	C1 NAG L 1535   ND2 ASN I 70   NAG-ASN
  LINKR	C1 NAG L 1545   ND2 ASN I 500   NAG-ASN
  LINKR	C1 NAG L 1525   ND2 ASN I 27   NAG-ASN

  LINKR	GLN G 98     PHE G 137   gap
  LINKR	ASN G 325    SER G 330   gap
  LINKR	LYS G 465    GLU G 472   gap
  LINKR	NAG J 1535    NAG J 1536   BETA1-4
  LINKR	NAG J 1545    NAG J 1546   BETA1-4
  LINKR	NAG J 1525    NAG J 1526   BETA1-4
  LINKR	PRO G 304    TYR G 306   gap
  LINKR	THR G 50    ILE G 309   gap
  LINKR	GLN H 98    PHE H 137   gap
  LINKR	ASN H 325    SER H 330   gap
  LINKR	LYS H 465    GLU H 472   gap
  LINKR	PRO H 304    TYR H 306   gap
  LINKR	THR H 50    ILE H 309   gap
  LINKR	GLN I 98    PHE I 137   gap
  LINKR	ASN I 325    SER I 330   gap
  LINKR	LYS I 465    GLU I 472   gap
  LINKR	PRO I 304    TYR I 306   gap
  LINKR	THR I 50    ILE I 309   gap
  LINKR	NAG K1535    NAG K1536   BETA1-4
  LINKR	NAG L1535    NAG L1536   BETA1-4
  LINKR	NAG K1545    NAG K1546   BETA1-4
  LINKR	NAG L1545    NAG L1546   BETA1-4
  LINKR	NAG K1525    NAG K1526   BETA1-4
  LINKR	NAG L1525    NAG L1526   BETA1-4

  MODRES	NAG J 1535 NAG-b-D	RENAME
  MODRES	NAG J 1536 NAG-b-D	RENAME
  MODRES	NAG J 1545 NAG-b-D	RENAME
  MODRES	NAG J 1546 NAG-b-D	RENAME
  MODRES	NAG J 1525 NAG-b-D	RENAME
  MODRES	NAG J 1526 NAG-b-D	RENAME
  MODRES	NAG K 1535 NAG-b-D	RENAME
  MODRES	NAG K 1536 NAG-b-D	RENAME
  MODRES	NAG K 1545 NAG-b-D	RENAME
  MODRES	NAG K 1546 NAG-b-D	RENAME
  MODRES	NAG K 1525 NAG-b-D	RENAME
  MODRES	NAG K 1526 NAG-b-D	RENAME
  MODRES	NAG L 1535 NAG-b-D	RENAME
  MODRES	NAG L 1536 NAG-b-D	RENAME
  MODRES	NAG L 1545 NAG-b-D	RENAME
  MODRES	NAG L 1546 NAG-b-D	RENAME
  MODRES	NAG L 1525 NAG-b-D	RENAME
  MODRES	NAG L 1526 NAG-b-D	RENAME

  CRYST1

  160.206 259.864 154.012 90.00 90.00 90.00 C 2 2 21

  SCALE1	0.006242 0.000000 0.000000  0.00000
  SCALE2	0.000000 0.003848 0.000000  0.00000
  SCALE3	0.000000 0.000000 0.006493  0.00000

  ATOM	1	N	GLN	G	26	24.299	30.940	−8.771	1.00	23.62		N
  ATOM	2	CA	GLN	G	26	22.913	30.470	−9.055	1.00	23.82		C
  ATOM	3	CB	GLN	G	26	22.260	29.923	−7.783	1.00	23.94		C
  ATOM	4	CG	GLN	G	26	23.103	28.894	−7.043	1.00	28.83		C
  ATOM	5	CD	GLN	G	26	24.309	29.508	−6.355	1.00	36.36		C
  ATOM	6	OE1	GLN	G	26	25.367	29.671	−6.963	1.00	39.09		O
  ATOM	7	NE2	GLN	G	26	24.176	29.785	−5.063	1.00	37.86		N
  ATOM	8	C	GLN	G	26	22.064	31.593	−9.645	1.00	23.09		C
  ATOM	9	O	GLN	G	26	22.368	32.772	−9.466	1.00	24.21		O
  ATOM	10	N	ASN	G	27	21.079	31.214	−10.452	1.00	20.98		N
  ATOM	11	CA	ASN	G	27	20.182	32.172	−11.089	1.00	19.70		C
  ATOM	12	CB	ASN	G	27	20.879	32.850	−12.269	1.00	20.41		C
  ATOM	13	CG	ASN	G	27	19.973	33.815	−13.014	1.00	23.56		C
  ATOM	14	OD1	ASN	G	27	19.456	34.775	−12.440	1.00	24.42		O
  ATOM	15	ND2	ASN	G	27	19.784	33.561	−14.310	1.00	27.70		N
  ATOM	16	C	ASN	G	27	18.931	31.465	−11.578	1.00	18.42		C
  ATOM	17	O	ASN	G	27	18.705	31.356	−12.783	1.00	18.47		O
  ATOM	18	N	ILE	G	28	18.240	30.807	−10.655	1.00	16.54		N
  ATOM	19	CA	ILE	G	28	17.060	30.044	−11.018	1.00	14.59		C
  ATOM	20	CB	ILE	G	28	16.771	28.910	−10.025	1.00	14.01		C
  ATOM	21	CG1	ILE	G	28	17.176	29.324	−8.610	1.00	15.60		C
  ATOM	22	CD1	ILE	G	28	16.159	30.199	−7.917	1.00	16.26		C
  ATOM	23	CG2	ILE	G	28	17.501	27.642	−10.441	1.00	12.57		C
  ATOM	24	C	ILE	G	28	15.843	30.942	−11.157	1.00	13.86		C
  ATOM	25	O	ILE	G	28	15.699	31.935	−10.443	1.00	13.70		O
  ATOM	26	N	THR	G	29	15.098	30.702	−12.227	1.00	13.23		N
  ATOM	27	CA	THR	G	29	13.968	31.532	−12.592	1.00	12.65		C
  ATOM	28	CB	THR	G	29	14.306	32.435	−13.790	1.00	12.69		C
  ATOM	29	OG1	THR	G	29	15.728	32.530	−13.936	1.00	12.62		O
  ATOM	30	CG2	THR	G	29	13.723	33.825	−13.594	1.00	12.92		C
  ATOM	31	C	THR	G	29	12.854	30.597	−13.010	1.00	12.47		C
  ATOM	32	O	THR	G	29	13.106	29.526	−13.560	1.00	12.53		O
  ATOM	33	N	GLU	G	30	11.622	31.050	−12.847	1.00	11.98		N
  ATOM	34	CA	GLU	G	30	10.500	30.392	−13.480	1.00	11.68		C
  ATOM	35	CB	GLU	G	30	9.587	29.781	−12.416	1.00	11.98		C
  ATOM	36	CG	GLU	G	30	8.848	28.524	−12.856	1.00	13.38		C
  ATOM	37	CD	GLU	G	30	8.295	27.732	−11.682	1.00	16.03		C
  ATOM	38	OE1	GLU	G	30	7.552	28.313	−10.863	1.00	16.65		O
  ATOM	39	OE2	GLU	G	30	8.577	26.519	−11.596	1.00	17.06		O
  ATOM	40	C	GLU	G	30	9.743	31.433	−14.281	1.00	11.39		C
  ATOM	41	O	GLU	G	30	9.521	32.547	−13.806	1.00	11.50		O
  ATOM	42	N	GLU	G	31	9.449	31.119	−15.535	1.00	11.11		N
  ATOM	43	CA	GLU	G	31	8.573	31.975	−16.305	1.00	11.06		C
  ATOM	44	CB	GLU	G	31	9.345	32.716	−17.394	1.00	11.48		C
  ATOM	45	CG	GLU	G	31	9.026	32.268	−18.803	1.00	13.90		C
  ATOM	46	CD	GLU	G	31	9.622	33.190	−19.843	1.00	17.27		C
  ATOM	47	OE1	GLU	G	31	8.852	33.749	−20.653	1.00	17.55		O
  ATOM	48	OE2	GLU	G	31	10.849	33.418	−19.804	1.00	18.73		O
  ATOM	49	C	GLU	G	31	7.370	31.240	−16.871	1.00	10.47		C
  ATOM	50	O	GLU	G	31	7.459	30.080	−17.274	1.00	10.12		O
  ATOM	51	N	PHE	G	32	6.220	31.890	−16.753	1.00	10.15		N
  ATOM	52	CA	PHE	G	32	4.932	31.235	−16.887	1.00	9.62		C
  ATOM	53	CB	PHE	G	32	3.967	31.777	−15.832	1.00	9.42		C
  ATOM	54	CG	PHE	G	32	2.524	31.512	−16.141	1.00	9.27		C
  ATOM	55	CD1	PHE	G	32	2.021	30.222	−16.085	1.00	9.37		C
  ATOM	56	CE1	PHE	G	32	0.701	29.960	−16.407	1.00	9.52		C
  ATOM	57	CZ	PHE	G	32	−0.132	30.993	−16.800	1.00	9.82		C
  ATOM	58	CE2	PHE	G	32	0.362	32.285	−16.877	1.00	10.13		C
  ATOM	59	CD2	PHE	G	32	1.681	32.541	−16.536	1.00	10.06		C
  ATOM	60	C	PHE	G	32	4.386	31.524	−18.276	1.00	9.64		C
  ATOM	61	O	PHE	G	32	4.479	32.650	−18.763	1.00	9.84		O
  ATOM	62	N	TYR	G	33	3.846	30.501	−18.926	1.00	9.59		N
  ATOM	63	CA	TYR	G	33	3.342	30.662	−20.281	1.00	9.67		C
  ATOM	64	CB	TYR	G	33	3.951	29.617	−21.212	1.00	9.52		C
  ATOM	65	CG	TYR	G	33	5.422	29.834	−21.467	1.00	10.94		C
  ATOM	66	CD1	TYR	G	33	6.379	29.220	−20.670	1.00	12.23		C
  ATOM	67	CE1	TYR	G	33	7.726	29.448	−20.870	1.00	12.93		C
  ATOM	68	CZ	TYR	G	33	8.128	30.348	−21.833	1.00	13.47		C
  ATOM	69	OH	TYR	G	33	9.469	30.588	−22.028	1.00	14.54		O
  ATOM	70	CE2	TYR	G	33	7.195	31.019	−22.594	1.00	13.56		C
  ATOM	71	CD2	TYR	G	33	5.850	30.781	−22.388	1.00	12.96		C
  ATOM	72	C	TYR	G	33	1.824	30.604	−20.327	1.00	9.94		C
  ATOM	73	O	TYR	G	33	1.234	29.530	−20.446	1.00	10.16		O
  ATOM	74	N	GLN	G	34	1.199	31.769	−20.211	1.00	10.06		N
  ATOM	75	CA	GLN	G	34	−0.225	31.846	−19.927	1.00	10.01		C
  ATOM	76	CB	GLN	G	34	−0.649	33.302	−19.751	1.00	10.22		C
  ATOM	77	CG	GLN	G	34	−2.138	33.486	−19.551	1.00	11.12		C
  ATOM	78	CD	GLN	G	34	−2.485	34.867	−19.039	1.00	13.13		C
  ATOM	79	OE1	GLN	G	34	−2.668	35.804	−19.819	1.00	14.24		O
  ATOM	80	NE2	GLN	G	34	−2.553	35.007	−17.719	1.00	13.79		N
  ATOM	81	C	GLN	G	34	−1.039	31.198	−21.039	1.00	9.94		C
  ATOM	82	O	GLN	G	34	−2.165	30.752	−20.819	1.00	10.08		O
  ATOM	83	N	SER	G	35	−0.468	31.167	−22.238	1.00	9.87		N
  ATOM	84	CA	SER	G	35	−1.185	30.690	−23.415	1.00	9.91		C
  ATOM	85	CB	SER	G	35	−0.619	31.337	−24.684	1.00	10.03		C
  ATOM	86	OG	SER	G	35	0.776	31.572	−24.564	1.00	10.81		O
  ATOM	87	C	SER	G	35	−1.119	29.167	−23.518	1.00	9.56		C
  ATOM	88	O	SER	G	35	−1.688	28.566	−24.431	1.00	9.59		O
  ATOM	89	N	THR	G	36	−0.417	28.553	−22.572	1.00	9.21		N
  ATOM	90	CA	THR	G	36	−0.209	27.113	−22.573	1.00	9.06		C
  ATOM	91	CB	THR	G	36	1.230	26.755	−23.010	1.00	9.49		C
  ATOM	92	OG1	THR	G	36	1.493	27.310	−24.305	1.00	10.82		O
  ATOM	93	CG2	THR	G	36	1.410	25.245	−23.074	1.00	9.45		C
  ATOM	94	C	THR	G	36	−0.455	26.599	−21.162	1.00	8.77		C
  ATOM	95	O	THR	G	36	−0.171	25.445	−20.845	1.00	8.60		O
  ATOM	96	N	CYS	G	37	−0.982	27.478	−20.315	1.00	8.69		N
  ATOM	97	CA	CYS	G	37	−1.097	27.201	−18.890	1.00	8.69		C
  ATOM	98	CB	CYS	G	37	−2.468	26.605	−18.571	1.00	8.81		C
  ATOM	99	SG	CYS	G	37	−3.003	26.848	−16.864	1.00	10.80		S
  ATOM	100	C	CYS	G	37	0.005	26.263	−18.414	1.00	8.27		C
  ATOM	101	O	CYS	G	37	−0.268	25.166	−17.926	1.00	8.27		O
  ATOM	102	N	SER	G	38	1.251	26.687	−18.586	1.00	7.92		N
  ATOM	103	CA	SER	G	38	2.386	25.886	−18.157	1.00	7.51		C
  ATOM	104	CB	SER	G	38	2.817	24.924	−19.264	1.00	7.63		C
  ATOM	105	OG	SER	G	38	3.392	25.627	−20.351	1.00	8.54		O
  ATOM	106	C	SER	G	38	3.558	26.757	−17.735	1.00	7.02		C
  ATOM	107	O	SER	G	38	3.663	27.917	−18.132	1.00	6.83		O
  ATOM	108	N	ALA	G	39	4.407	26.198	−16.882	1.00	6.64		N
  ATOM	109	CA	ALA	G	39	5.466	26.961	−16.245	1.00	6.58		C
  ATOM	110	CB	ALA	G	39	5.136	27.195	−14.782	1.00	6.67		C
  ATOM	111	C	ALA	G	39	6.789	26.222	−16.382	1.00	6.93		C
  ATOM	112	O	ALA	G	39	6.842	24.998	−16.261	1.00	7.38		O
  ATOM	113	N	VAL	G	40	7.843	26.966	−16.698	1.00	6.87		N
  ATOM	114	CA	VAL	G	40	9.175	26.388	−16.797	1.00	6.55		C
  ATOM	115	CB	VAL	G	40	9.741	26.507	−18.222	1.00	6.22		C
  ATOM	116	CG1	VAL	G	40	11.237	26.233	−18.223	1.00	6.52		C
  ATOM	117	CG2	VAL	G	40	9.018	25.553	−19.160	1.00	6.62		C
  ATOM	118	C	VAL	G	40	10.140	27.033	−15.813	1.00	6.73		C
  ATOM	119	O	VAL	G	40	10.302	28.253	−15.789	1.00	6.83		O
  ATOM	120	N	SER	G	41	10.772	26.198	−14.997	1.00	6.86		N
  ATOM	121	CA	SER	G	41	11.897	26.625	−14.181	1.00	6.75		C
  ATOM	122	CB	SER	G	41	11.974	25.785	−12.905	1.00	7.06		C
  ATOM	123	OG	SER	G	41	10.751	25.110	−12.666	1.00	7.50		O
  ATOM	124	C	SER	G	41	13.206	26.525	−14.958	1.00	6.56		C
  ATOM	125	O	SER	G	41	13.526	25.482	−15.529	1.00	6.08		O
  ATOM	126	N	LYS	G	42	13.972	27.612	−14.946	1.00	7.02		N
  ATOM	127	CA	LYS	G	42	15.140	27.757	−15.809	1.00	7.83		C
  ATOM	128	CB	LYS	G	42	14.949	28.933	−16.769	1.00	8.15		C
  ATOM	129	CG	LYS	G	42	13.666	28.888	−17.578	1.00	9.75		C
  ATOM	130	CD	LYS	G	42	13.510	30.148	−18.414	1.00	12.62		C
  ATOM	131	CE	LYS	G	42	12.360	30.022	−19.398	1.00	14.04		C
  ATOM	132	NZ	LYS	G	42	12.643	30.734	−20.675	1.00	14.96		N
  ATOM	133	C	LYS	G	42	16.394	27.988	−14.971	1.00	7.80		C
  ATOM	134	O	LYS	G	42	16.323	28.557	−13.882	1.00	8.15		O
  ATOM	135	N	GLY	G	43	17.550	27.717	−15.566	1.00	7.59		N
  ATOM	136	CA	GLY	G	43	18.820	28.160	−15.002	1.00	7.35		C
  ATOM	137	C	GLY	G	43	19.529	27.058	−14.240	1.00	7.10		C
  ATOM	138	O	GLY	G	43	20.294	27.323	−13.313	1.00	7.13		O
  ATOM	139	N	TYR	G	44	19.309	25.819	−14.668	1.00	7.01		N
  ATOM	140	CA	TYR	G	44	19.922	24.656	−14.033	1.00	6.89		C
  ATOM	141	CB	TYR	G	44	18.878	23.561	−13.815	1.00	6.88		C
  ATOM	142	CG	TYR	G	44	17.809	23.928	−12.816	1.00	6.41		C
  ATOM	143	CD1	TYR	G	44	16.553	24.343	−13.236	1.00	6.62		C
  ATOM	144	CE1	TYR	G	44	15.580	24.703	−12.325	1.00	6.48		C
  ATOM	145	CZ	TYR	G	44	15.862	24.662	−10.976	1.00	6.88		C
  ATOM	146	OH	TYR	G	44	14.897	25.025	−10.065	1.00	7.50		O
  ATOM	147	CE2	TYR	G	44	17.110	24.279	−10.536	1.00	6.68		C
  ATOM	148	CD2	TYR	G	44	18.077	23.922	−11.454	1.00	5.91		C
  ATOM	149	C	TYR	G	44	21.060	24.106	−14.886	1.00	6.86		C
  ATOM	150	O	TYR	G	44	21.012	24.190	−16.113	1.00	7.14		O
  ATOM	151	N	LEU	G	45	21.979	23.385	−14.249	1.00	6.44		N
  ATOM	152	CA	LEU	G	45	23.146	22.842	−14.946	1.00	6.12		C
  ATOM	153	CB	LEU	G	45	24.425	23.552	−14.482	1.00	6.31		C
  ATOM	154	CG	LEU	G	45	24.534	25.052	−14.775	1.00	6.38		C
  ATOM	155	CD1	LEU	G	45	25.624	25.690	−13.928	1.00	7.05		C
  ATOM	156	CD2	LEU	G	45	24.787	25.299	−16.255	1.00	7.05		C
  ATOM	157	C	LEU	G	45	23.279	21.312	−14.800	1.00	5.84		C
  ATOM	158	O	LEU	G	45	23.333	20.797	−13.683	1.00	5.94		O
  ATOM	159	N	SER	G	46	23.470	20.620	−15.929	1.00	5.43		N
  ATOM	160	CA	SER	G	46	23.249	19.157	−16.047	1.00	5.26		C
  ATOM	161	CB	SER	G	46	22.913	18.795	−17.498	1.00	5.21		C
  ATOM	162	OG	SER	G	46	24.090	18.532	−18.243	1.00	4.95		O
  ATOM	163	C	SER	G	46	24.481	18.355	−15.585	1.00	5.51		C
  ATOM	164	O	SER	G	46	25.480	18.961	−15.200	1.00	6.03		O
  ATOM	165	N	ALA	G	47	24.453	17.015	−15.656	1.00	5.24		N
  ATOM	166	CA	ALA	G	47	25.584	16.224	−15.104	1.00	4.83		C
  ATOM	167	CB	ALA	G	47	25.690	16.412	−13.599	1.00	5.01		C
  ATOM	168	C	ALA	G	47	25.854	14.751	−15.494	1.00	4.35		C
  ATOM	169	O	ALA	G	47	24.926	13.972	−15.719	1.00	4.45		O
  ATOM	170	N	LEU	G	48	27.119	14.348	−15.323	1.00	3.67		N
  ATOM	171	CA	LEU	G	48	27.564	12.948	−15.451	1.00	3.15		C
  ATOM	172	CB	LEU	G	48	28.365	12.755	−16.750	1.00	2.78		C
  ATOM	173	CG	LEU	G	48	27.659	12.681	−18.108	1.00	2.18		C
  ATOM	174	CD1	LEU	G	48	28.223	11.532	−18.935	1.00	2.00		C
  ATOM	175	CD2	LEU	G	48	26.156	12.531	−17.934	1.00	3.94		C
  ATOM	176	C	LEU	G	48	28.443	12.517	−14.259	1.00	3.06		C
  ATOM	177	O	LEU	G	48	29.670	12.486	−14.373	1.00	3.27		O
  ATOM	178	N	ARG	G	49	27.810	12.061	−13.177	1.00	2.91		N
  ATOM	179	CA	ARG	G	49	28.509	11.788	−11.915	1.00	2.88		C
  ATOM	180	CB	ARG	G	49	27.538	11.277	−10.847	1.00	2.69		C
  ATOM	181	CG	ARG	G	49	28.117	11.273	−9.440	1.00	2.15		C
  ATOM	182	CD	ARG	G	49	28.015	9.897	−8.806	1.00	2.00		C
  ATOM	183	NE	ARG	G	49	29.322	9.271	−8.623	1.00	5.18		N
  ATOM	184	CZ	ARG	G	49	29.526	7.956	−8.629	1.00	7.68		C
  ATOM	185	NH1	ARG	G	49	28.518	7.129	−8.866	1.00	8.32		N
  ATOM	186	NH2	ARG	G	49	30.748	7.469	−8.455	1.00	8.12		N
  ATOM	187	C	ARG	G	49	29.678	10.816	−12.065	1.00	3.09		C
  ATOM	188	O	ARG	G	49	29.570	9.796	−12.747	1.00	3.08		O
  ATOM	189	N	THR	G	50	30.820	11.189	−11.489	1.00	3.37		N
  ATOM	190	CA	THR	G	50	32.099	10.564	−11.823	1.00	3.55		C
  ATOM	191	CB	THR	G	50	32.487	10.773	−13.299	1.00	3.25		C
  ATOM	192	OG1	THR	G	50	32.842	12.144	−13.519	1.00	2.66		O
  ATOM	193	CG2	THR	G	50	31.328	10.401	−14.212	1.00	3.46		C
  ATOM	194	C	THR	G	50	33.259	10.968	−10.908	1.00	4.07		C
  ATOM	195	O	THR	G	50	33.768	10.130	−10.165	1.00	4.35		O
  ATOM	196	N	GLY	G	51	33.818	12.158	−11.108	1.00	4.24		N
  ATOM	197	CA	GLY	G	51	34.942	12.544	−10.272	1.00	4.78		C
  ATOM	198	C	GLY	G	51	34.692	11.849	−8.951	1.00	4.98		C
  ATOM	199	O	GLY	G	51	33.618	12.018	−8.375	1.00	5.00		O
  ATOM	200	N	TRP	G	52	35.476	10.816	−8.667	1.00	5.34		N
  ATOM	201	CA	TRP	G	52	35.123	9.926	−7.569	1.00	5.42		C
  ATOM	202	CB	TRP	G	52	34.864	8.497	−8.049	1.00	5.75		C
  ATOM	203	CG	TRP	G	52	33.714	8.373	−9.001	1.00	6.38		C
  ATOM	204	CD1	TRP	G	52	33.776	7.964	−10.300	1.00	7.27		C
  ATOM	205	NE1	TRP	G	52	32.533	8.031	−10.878	1.00	7.46		N
  ATOM	206	CE2	TRP	G	52	31.627	8.449	−9.938	1.00	7.15		C
  ATOM	207	CD2	TRP	G	52	32.331	8.658	−8.735	1.00	7.02		C
  ATOM	208	CE3	TRP	G	52	31.627	9.102	−7.608	1.00	6.83		C
  ATOM	209	CZ3	TRP	G	52	30.261	9.289	−7.711	1.00	6.73		C
  ATOM	210	CH2	TRP	G	52	29.589	9.062	−8.922	1.00	7.13		C
  ATOM	211	CZ2	TRP	G	52	30.252	8.637	−10.041	1.00	6.82		C
  ATOM	212	C	TRP	G	52	36.148	9.926	−6.456	1.00	5.34		C
  ATOM	213	O	TRP	G	52	37.349	10.027	−6.698	1.00	5.47		O
  ATOM	214	N	TYR	G	53	35.670	9.629	−5.256	1.00	5.29		N
  ATOM	215	CA	TYR	G	53	36.528	9.560	−4.093	1.00	5.58		C
  ATOM	216	CB	TYR	G	53	36.260	10.754	−3.176	1.00	5.51		C
  ATOM	217	CG	TYR	G	53	37.079	10.756	−1.910	1.00	6.59		C
  ATOM	218	CD1	TYR	G	53	38.312	11.391	−1.858	1.00	8.25		C
  ATOM	219	CE1	TYR	G	53	39.043	11.436	−0.685	1.00	9.40		C
  ATOM	220	CZ	TYR	G	53	38.524	10.875	0.462	1.00	9.24		C
  ATOM	221	OH	TYR	G	53	39.246	10.915	1.633	1.00	9.61		O
  ATOM	222	CE2	TYR	G	53	37.287	10.272	0.443	1.00	8.78		C
  ATOM	223	CD2	TYR	G	53	36.559	10.247	−0.730	1.00	7.93		C
  ATOM	224	C	TYR	G	53	36.286	8.245	−3.364	1.00	5.74		C
  ATOM	225	O	TYR	G	53	35.186	7.996	−2.870	1.00	6.19		O
  ATOM	226	N	THR	G	54	37.221	7.317	−3.532	1.00	6.04		N
  ATOM	227	CA	THR	G	54	37.132	6.013	−2.888	1.00	6.67		C
  ATOM	228	CB	THR	G	54	38.232	5.060	−3.396	1.00	6.97		C
  ATOM	229	OG1	THR	G	54	37.876	4.562	−4.691	1.00	7.51		O
  ATOM	230	CG2	THR	G	54	38.409	3.889	−2.442	1.00	7.98		C
  ATOM	231	C	THR	G	54	37.254	6.158	−1.376	1.00	6.97		C
  ATOM	232	O	THR	G	54	37.900	7.083	−0.884	1.00	7.32		O
  ATOM	233	N	SER	G	55	36.616	5.254	−0.639	1.00	7.24		N
  ATOM	234	CA	SER	G	55	37.025	4.966	0.732	1.00	7.65		C
  ATOM	235	CB	SER	G	55	36.459	6.009	1.705	1.00	7.69		C
  ATOM	236	OG	SER	G	55	36.690	5.632	3.053	1.00	7.51		O
  ATOM	237	C	SER	G	55	36.629	3.561	1.171	1.00	8.03		C
  ATOM	238	O	SER	G	55	35.510	3.109	0.924	1.00	8.43		O
  ATOM	239	N	VAL	G	56	37.522	2.919	1.915	1.00	8.14		N
  ATOM	240	CA	VAL	G	56	37.401	1.500	2.215	1.00	8.41		C
  ATOM	241	CB	VAL	G	56	38.732	0.763	1.967	1.00	8.72		C
  ATOM	242	CG1	VAL	G	56	38.479	−0.703	1.654	1.00	9.29		C
  ATOM	243	CG2	VAL	G	56	39.509	1.433	0.843	1.00	9.51		C
  ATOM	244	C	VAL	G	56	37.005	1.312	3.673	1.00	8.19		C
  ATOM	245	O	VAL	G	56	37.760	1.658	4.578	1.00	8.54		O
  ATOM	246	N	ILE	G	57	35.784	0.845	3.898	1.00	7.91		N
  ATOM	247	CA	ILE	G	57	35.255	0.779	5.249	1.00	7.64		C
  ATOM	248	CB	ILE	G	57	33.912	1.510	5.372	1.00	7.35		C
  ATOM	249	CG1	ILE	G	57	34.063	2.964	4.918	1.00	7.25		C
  ATOM	250	CD1	ILE	G	57	32.922	3.860	5.343	1.00	8.42		C
  ATOM	251	CG2	ILE	G	57	33.404	1.449	6.804	1.00	7.52		C
  ATOM	252	C	ILE	G	57	35.125	−0.655	5.739	1.00	7.69		C
  ATOM	253	O	ILE	G	57	34.629	−1.527	5.025	1.00	7.79		O
  ATOM	254	N	THR	G	58	35.726	−0.917	6.894	1.00	7.85		N
  ATOM	255	CA	THR	G	58	35.912	−2.275	7.379	1.00	8.15		C
  ATOM	256	CB	THR	G	58	37.405	−2.631	7.469	1.00	8.14		C
  ATOM	257	OG1	THR	G	58	38.159	−1.761	6.615	1.00	8.62		O
  ATOM	258	CG2	THR	G	58	37.634	−4.075	7.053	1.00	7.94		C
  ATOM	259	C	THR	G	58	35.291	−2.414	8.763	1.00	8.20		C
  ATOM	260	O	THR	G	58	35.589	−1.633	9.664	1.00	8.18		O
  ATOM	261	N	ILE	G	59	34.396	−3.384	8.915	1.00	8.54		N
  ATOM	262	CA	ILE	G	59	33.617	−3.525	10.143	1.00	9.23		C
  ATOM	263	CB	ILE	G	59	32.144	−3.139	9.912	1.00	8.92		C
  ATOM	264	CG1	ILE	G	59	32.031	−1.688	9.443	1.00	9.27		C
  ATOM	265	CD1	ILE	G	59	30.626	−1.285	9.045	1.00	10.89		C
  ATOM	266	CG2	ILE	G	59	31.326	−3.377	11.170	1.00	8.74		C
  ATOM	267	C	ILE	G	59	33.648	−4.973	10.621	1.00	10.02		C
  ATOM	268	O	ILE	G	59	33.170	−5.865	9.921	1.00	10.20		O
  ATOM	269	N	GLU	G	60	34.251	−5.221	11.779	1.00	10.95		N
  ATOM	270	CA	GLU	G	60	34.630	−6.586	12.133	1.00	12.13		C
  ATOM	271	CB	GLU	G	60	35.311	−6.605	13.510	1.00	12.44		C
  ATOM	272	CG	GLU	G	60	36.583	−5.750	13.558	1.00	15.04		C
  ATOM	273	CD	GLU	G	60	37.500	−6.089	14.724	1.00	19.34		C
  ATOM	274	OE1	GLU	G	60	37.163	−5.716	15.869	1.00	20.63		O
  ATOM	275	OE2	GLU	G	60	38.625	−6.578	14.476	1.00	21.19		O
  ATOM	276	C	GLU	G	60	33.397	−7.503	12.086	1.00	12.46		C
  ATOM	277	O	GLU	G	60	32.369	−7.164	12.677	1.00	12.68		O
  ATOM	278	N	LEU	G	61	33.448	−8.627	11.361	1.00	12.80		N
  ATOM	279	CA	LEU	G	61	32.635	−9.731	11.843	1.00	12.71		C
  ATOM	280	CB	LEU	G	61	32.816	−11.079	11.148	1.00	12.55		C
  ATOM	281	CG	LEU	G	61	31.902	−12.059	11.912	1.00	12.39		C
  ATOM	282	CD1	LEU	G	61	30.438	−11.897	11.514	1.00	13.14		C
  ATOM	283	CD2	LEU	G	61	32.335	−13.513	11.814	1.00	12.50		C
  ATOM	284	C	LEU	G	61	33.223	−9.800	13.207	1.00	12.94		C
  ATOM	285	O	LEU	G	61	34.388	−10.187	13.351	1.00	12.78		O
  ATOM	286	N	SER	G	62	32.676	−8.895	13.997	1.00	13.61		N
  ATOM	287	CA	SER	G	62	32.941	−8.871	15.409	1.00	14.70		C
  ATOM	288	CB	SER	G	62	32.339	−7.611	16.023	1.00	14.52		C
  ATOM	289	OG	SER	G	62	32.798	−6.455	15.345	1.00	14.80		O
  ATOM	290	C	SER	G	62	32.342	−10.111	16.051	1.00	15.48		C
  ATOM	291	O	SER	G	62	31.132	−10.187	16.263	1.00	15.50		O
  ATOM	292	N	ASN	G	63	33.164	−11.141	16.199	1.00	16.61		N
  ATOM	293	CA	ASN	G	63	32.650	−12.422	16.635	1.00	17.77		C
  ATOM	294	CB	ASN	G	63	33.597	−13.559	16.266	1.00	17.73		C
  ATOM	295	CG	ASN	G	63	32.857	−14.834	15.934	1.00	18.52		C
  ATOM	296	OD1	ASN	G	63	31.848	−15.156	16.561	1.00	18.29		O
  ATOM	297	ND2	ASN	G	63	33.295	−15.516	14.883	1.00	19.40		N
  ATOM	298	C	ASN	G	63	32.325	−12.448	18.119	1.00	18.53		C
  ATOM	299	O	ASN	G	63	32.967	−11.768	18.919	1.00	18.82		O
  ATOM	300	N	ILE	G	64	31.240	−13.135	18.457	1.00	19.60		N
  ATOM	301	CA	ILE	G	64	30.912	−13.413	19.848	1.00	21.04		C
  ATOM	302	CB	ILE	G	64	29.403	−13.648	20.038	1.00	20.60		C
  ATOM	303	CG1	ILE	G	64	28.593	−12.612	19.259	1.00	20.13		C
  ATOM	304	CD1	ILE	G	64	27.150	−12.497	19.722	1.00	20.19		C
  ATOM	305	CG2	ILE	G	64	29.040	−13.615	21.514	1.00	20.74		C
  ATOM	306	C	ILE	G	64	31.660	−14.643	20.347	1.00	22.58		C
  ATOM	307	O	ILE	G	64	31.672	−15.682	19.687	1.00	23.07		O
  ATOM	308	N	LYS	G	65	32.173	−14.559	21.570	1.00	24.21		N
  ATOM	309	CA	LYS	G	65	32.425	−15.751	22.374	1.00	25.86		C
  ATOM	310	CB	LYS	G	65	33.801	−15.682	23.043	1.00	25.90		C
  ATOM	311	CG	LYS	G	65	34.437	−14.301	23.031	1.00	26.69		C
  ATOM	312	CD	LYS	G	65	33.621	−13.312	23.847	1.00	28.26		C
  ATOM	313	CE	LYS	G	65	34.477	−12.614	24.890	1.00	28.67		C
  ATOM	314	NZ	LYS	G	65	33.661	−12.120	26.034	1.00	28.95		N
  ATOM	315	C	LYS	G	65	31.329	−15.991	23.413	1.00	26.81		C
  ATOM	316	O	LYS	G	65	31.299	−15.345	24.461	1.00	26.72		O
  ATOM	317	N	GLU	G	66	30.491	−16.990	23.149	1.00	27.90		N
  ATOM	318	CA	GLU	G	66	29.237	−17.188	23.879	1.00	28.82		C
  ATOM	319	CB	GLU	G	66	28.305	−18.104	23.076	1.00	28.88		C
  ATOM	320	CG	GLU	G	66	27.621	−19.192	23.895	1.00	30.33		C
  ATOM	321	CD	GLU	G	66	27.188	−20.381	23.052	1.00	33.17		C
  ATOM	322	OE1	GLU	G	66	26.253	−21.098	23.468	1.00	35.05		O
  ATOM	323	OE2	GLU	G	66	27.824	−20.634	22.007	1.00	33.14		O
  ATOM	324	C	GLU	G	66	29.494	−17.783	25.263	1.00	29.12		C
  ATOM	325	O	GLU	G	66	30.348	−18.655	25.418	1.00	29.28		O
  ATOM	326	N	ASN	G	67	28.773	−17.301	26.272	1.00	29.32		N
  ATOM	327	CA	ASN	G	67	29.094	−17.661	27.650	1.00	29.39		C
  ATOM	328	CB	ASN	G	67	29.462	−16.429	28.477	1.00	29.62		C
  ATOM	329	CG	ASN	G	67	30.963	−16.231	28.580	1.00	29.84		C
  ATOM	330	OD1	ASN	G	67	31.651	−17.000	29.252	1.00	29.93		O
  ATOM	331	ND2	ASN	G	67	31.494	−15.324	27.768	1.00	29.22		N
  ATOM	332	C	ASN	G	67	28.069	−18.540	28.367	1.00	29.15		C
  ATOM	333	O	ASN	G	67	27.324	−18.070	29.227	1.00	29.06		O
  ATOM	334	N	LYS	G	68	27.964	−19.788	27.921	1.00	28.87		N
  ATOM	335	CA	LYS	G	68	27.848	−20.936	28.819	1.00	28.78		C
  ATOM	336	CB	LYS	G	68	29.127	−21.783	28.771	1.00	28.89		C
  ATOM	337	CG	LYS	G	68	29.681	−22.003	27.364	1.00	29.26		C
  ATOM	338	CD	LYS	G	68	31.070	−22.631	27.392	1.00	29.68		C
  ATOM	339	CE	LYS	G	68	31.200	−23.648	28.514	1.00	29.46		C
  ATOM	340	NZ	LYS	G	68	32.473	−24.417	28.425	1.00	29.58		N
  ATOM	341	C	LYS	G	68	27.492	−20.555	30.268	1.00	28.60		C
  ATOM	342	O	LYS	G	68	28.346	−20.603	31.154	1.00	28.64		O
  ATOM	343	N	CYS	G	69	26.261	−20.069	30.468	1.00	28.09		N
  ATOM	344	CA	CYS	G	69	25.535	−20.153	31.759	1.00	27.63		C
  ATOM	345	CB	CYS	G	69	25.056	−18.753	32.214	1.00	27.07		C
  ATOM	346	SG	CYS	G	69	23.368	−18.230	31.662	1.00	28.01		S
  ATOM	347	C	CYS	G	69	24.339	−21.120	31.667	1.00	27.69		C
  ATOM	348	O	CYS	G	69	23.967	−21.533	30.570	1.00	27.41		O
  ATOM	349	N	ASN	G	70	23.718	−21.458	32.800	1.00	28.06		N
  ATOM	350	CA	ASN	G	70	22.359	−22.029	32.778	1.00	28.87		C
  ATOM	351	CB	ASN	G	70	22.332	−23.517	33.167	1.00	30.52		C
  ATOM	352	CG	ASN	G	70	23.711	−24.156	33.213	1.00	39.60		C
  ATOM	353	OD1	ASN	G	70	24.336	−24.404	32.180	1.00	44.97		O
  ATOM	354	ND2	ASN	G	70	24.204	−24.392	34.429	1.00	51.04		N
  ATOM	355	C	ASN	G	70	21.297	−21.261	33.577	1.00	26.97		C
  ATOM	356	O	ASN	G	70	21.275	−21.320	34.807	1.00	26.50		O
  ATOM	357	N	GLY	G	71	20.320	−20.703	32.866	1.00	25.46		N
  ATOM	358	CA	GLY	G	71	19.231	−19.956	33.496	1.00	23.67		C
  ATOM	359	C	GLY	G	71	17.990	−20.807	33.709	1.00	22.81		C
  ATOM	360	O	GLY	G	71	18.004	−22.008	33.436	1.00	22.79		O
  ATOM	361	N	THR	G	72	16.924	−20.195	34.225	1.00	21.93		N
  ATOM	362	CA	THR	G	72	15.666	−20.910	34.453	1.00	21.30		C
  ATOM	363	CB	THR	G	72	14.737	−20.162	35.441	1.00	21.12		C
  ATOM	364	OG1	THR	G	72	14.073	−19.090	34.761	1.00	19.87		O
  ATOM	365	CG2	THR	G	72	15.532	−19.609	36.619	1.00	20.76		C
  ATOM	366	C	THR	G	72	14.923	−21.169	33.139	1.00	21.50		C
  ATOM	367	O	THR	G	72	14.471	−20.236	32.474	1.00	21.85		O
  ATOM	368	N	ASP	G	73	14.797	−22.445	32.781	1.00	21.43		N
  ATOM	369	CA	ASP	G	73	14.514	−22.861	31.404	1.00	21.46		C
  ATOM	370	CB	ASP	G	73	13.109	−22.427	30.971	1.00	21.69		C
  ATOM	371	CG	ASP	G	73	12.794	−22.806	29.529	1.00	22.46		C
  ATOM	372	OD1	ASP	G	73	13.730	−22.837	28.701	1.00	23.01		O
  ATOM	373	OD2	ASP	G	73	11.611	−23.068	29.224	1.00	23.09		O
  ATOM	374	C	ASP	G	73	15.561	−22.365	30.406	1.00	20.96		C
  ATOM	375	O	ASP	G	73	15.703	−21.161	30.188	1.00	20.61		O
  ATOM	376	N	ALA	G	74	16.237	−23.305	29.748	1.00	20.42		N
  ATOM	377	CA	ALA	G	74	17.299	−22.967	28.802	1.00	20.38		C
  ATOM	378	CB	ALA	G	74	18.658	−23.365	29.363	1.00	20.11		C
  ATOM	379	C	ALA	G	74	17.092	−23.586	27.421	1.00	20.45		C
  ATOM	380	O	ALA	G	74	18.059	−23.849	26.707	1.00	20.46		O
  ATOM	381	N	LYS	G	75	15.839	−23.747	27.010	1.00	20.67		N
  ATOM	382	CA	LYS	G	75	15.550	−24.031	25.610	1.00	20.99		C
  ATOM	383	CB	LYS	G	75	14.110	−24.512	25.445	1.00	21.20		C
  ATOM	384	CG	LYS	G	75	13.808	−25.810	26.181	1.00	22.02		C
  ATOM	385	CD	LYS	G	75	12.692	−25.624	27.198	1.00	23.66		C
  ATOM	386	CE	LYS	G	75	13.000	−26.348	28.498	1.00	24.93		C
  ATOM	387	NZ	LYS	G	75	12.517	−25.588	29.683	1.00	25.55		N
  ATOM	388	C	LYS	G	75	15.798	−22.788	24.765	1.00	20.92		C
  ATOM	389	O	LYS	G	75	16.187	−22.880	23.600	1.00	20.92		O
  ATOM	390	N	VAL	G	76	15.659	−21.629	25.399	1.00	20.63		N
  ATOM	391	CA	VAL	G	76	16.187	−20.379	24.872	1.00	20.36		C
  ATOM	392	CB	VAL	G	76	15.654	−19.174	25.673	1.00	20.25		C
  ATOM	393	CG1	VAL	G	76	16.330	−17.891	25.215	1.00	20.82		C
  ATOM	394	CG2	VAL	G	76	14.139	−19.068	25.530	1.00	20.09		C
  ATOM	395	C	VAL	G	76	17.717	−20.356	24.872	1.00	20.29		C
  ATOM	396	O	VAL	G	76	18.353	−20.568	25.905	1.00	20.21		O
  ATOM	397	N	LYS	G	77	18.294	−20.039	23.716	1.00	20.17		N
  ATOM	398	CA	LYS	G	77	19.745	−20.018	23.547	1.00	20.17		C
  ATOM	399	CB	LYS	G	77	20.267	−21.419	23.194	1.00	20.62		C
  ATOM	400	CG	LYS	G	77	20.894	−22.180	24.367	1.00	23.31		C
  ATOM	401	CD	LYS	G	77	20.940	−23.684	24.105	1.00	26.74		C
  ATOM	402	CE	LYS	G	77	21.242	−24.468	25.376	1.00	28.32		C
  ATOM	403	NZ	LYS	G	77	21.041	−25.932	25.189	1.00	29.66		N
  ATOM	404	C	LYS	G	77	20.159	−19.010	22.468	1.00	19.45		C
  ATOM	405	O	LYS	G	77	20.754	−19.378	21.453	1.00	19.36		O
  ATOM	406	N	LEU	G	78	19.862	−17.736	22.710	1.00	18.70		N
  ATOM	407	CA	LEU	G	78	19.857	−16.728	21.656	1.00	17.98		C
  ATOM	408	CB	LEU	G	78	19.534	−15.357	22.246	1.00	17.72		C
  ATOM	409	CG	LEU	G	78	18.293	−15.357	23.142	1.00	17.51		C
  ATOM	410	CD1	LEU	G	78	18.117	−14.023	23.860	1.00	17.41		C
  ATOM	411	CD2	LEU	G	78	17.045	−15.734	22.349	1.00	17.62		C
  ATOM	412	C	LEU	G	78	21.181	−16.680	20.908	1.00	17.77		C
  ATOM	413	O	LEU	G	78	21.209	−16.672	19.678	1.00	17.89		O
  ATOM	414	N	ILE	G	79	22.273	−16.585	21.657	1.00	17.29		N
  ATOM	415	CA	ILE	G	79	23.592	−16.438	21.058	1.00	17.00		C
  ATOM	416	CB	ILE	G	79	24.691	−16.295	22.126	1.00	16.96		C
  ATOM	417	CG1	ILE	G	79	24.486	−15.011	22.932	1.00	17.21		C
  ATOM	418	CD1	ILE	G	79	25.529	−14.794	24.009	1.00	17.51		C
  ATOM	419	CG2	ILE	G	79	26.066	−16.303	21.477	1.00	17.30		C
  ATOM	420	C	ILE	G	79	23.923	−17.616	20.147	1.00	16.83		C
  ATOM	421	O	ILE	G	79	24.307	−17.428	18.992	1.00	17.02		O
  ATOM	422	N	LYS	G	80	23.678	−18.870	20.478	1.00	16.55		N
  ATOM	423	CA	LYS	G	80	24.058	−19.851	19.437	1.00	16.38		C
  ATOM	424	CB	LYS	G	80	23.872	−21.278	19.959	1.00	16.73		C
  ATOM	425	CG	LYS	G	80	24.274	−22.360	18.971	1.00	17.99		C
  ATOM	426	CD	LYS	G	80	25.741	−22.245	18.590	1.00	20.71		C
  ATOM	427	CE	LYS	G	80	26.170	−23.396	17.697	1.00	22.92		C
  ATOM	428	NZ	LYS	G	80	25.352	−23.472	16.454	1.00	24.75		N
  ATOM	429	C	LYS	G	80	23.334	−19.690	18.060	1.00	15.79		C
  ATOM	430	O	LYS	G	80	23.970	−19.700	16.969	1.00	15.32		O
  ATOM	431	N	GLN	G	81	22.019	−19.489	18.112	1.00	15.48		N
  ATOM	432	CA	GLN	G	81	21.192	−19.385	16.905	1.00	15.33		C
  ATOM	433	CB	GLN	G	81	19.711	−19.320	17.287	1.00	15.70		C
  ATOM	434	CG	GLN	G	81	19.269	−20.415	18.242	1.00	17.88		C
  ATOM	435	CD	GLN	G	81	17.848	−20.225	18.734	1.00	20.46		C
  ATOM	436	OE1	GLN	G	81	17.116	−19.367	18.241	1.00	21.59		O
  ATOM	437	NE2	GLN	G	81	17.451	−21.028	19.716	1.00	20.26		N
  ATOM	438	C	GLN	G	81	21.546	−18.192	16.019	1.00	14.63		C
  ATOM	439	O	GLN	G	81	21.582	−18.295	14.780	1.00	14.60		O
  ATOM	440	N	GLU	G	82	21.808	−17.057	16.658	1.00	13.81		N
  ATOM	441	CA	GLU	G	82	22.159	−15.854	15.925	1.00	13.37		C
  ATOM	442	CB	GLU	G	82	22.317	−14.664	16.873	1.00	13.20		C
  ATOM	443	CG	GLU	G	82	21.010	−13.984	17.235	1.00	15.04		C
  ATOM	444	CD	GLU	G	82	20.314	−13.388	16.026	1.00	17.51		C
  ATOM	445	OE1	GLU	G	82	19.726	−12.293	16.154	1.00	18.22		O
  ATOM	446	OE2	GLU	G	82	20.355	−14.015	14.946	1.00	17.87		O
  ATOM	447	C	GLU	G	82	23.450	−16.101	15.169	1.00	12.99		C
  ATOM	448	O	GLU	G	82	23.584	−15.705	14.014	1.00	12.89		O
  ATOM	449	N	LEU	G	83	24.393	−16.778	15.815	1.00	12.89		N
  ATOM	450	CA	LEU	G	83	25.665	−17.066	15.174	1.00	13.08		C
  ATOM	451	CB	LEU	G	83	26.613	−17.761	16.151	1.00	13.26		C
  ATOM	452	CG	LEU	G	83	26.970	−16.978	17.415	1.00	14.18		C
  ATOM	453	CD1	LEU	G	83	27.933	−17.774	18.282	1.00	15.11		C
  ATOM	454	CD2	LEU	G	83	27.557	−15.620	17.059	1.00	14.79		C
  ATOM	455	C	LEU	G	83	25.444	−17.940	13.949	1.00	13.18		C
  ATOM	456	O	LEU	G	83	26.007	−17.673	12.876	1.00	13.05		O
  ATOM	457	N	ASP	G	84	24.588	−18.953	14.074	1.00	13.56		N
  ATOM	458	CA	ASP	G	84	24.346	−19.788	12.891	1.00	14.15		C
  ATOM	459	CB	ASP	G	84	23.439	−20.973	13.232	1.00	14.80		C
  ATOM	460	CG	ASP	G	84	24.004	−21.841	14.338	1.00	18.26		C
  ATOM	461	OD1	ASP	G	84	24.605	−22.891	14.026	1.00	21.11		O
  ATOM	462	OD2	ASP	G	84	23.837	−21.480	15.520	1.00	22.12		O
  ATOM	463	C	ASP	G	84	23.737	−18.979	11.731	1.00	13.56		C
  ATOM	464	O	ASP	G	84	24.147	−19.111	10.549	1.00	13.70		O
  ATOM	465	N	LYS	G	85	22.780	−18.115	12.068	1.00	12.87		N
  ATOM	466	CA	LYS	G	85	22.128	−17.318	11.033	1.00	12.31		C
  ATOM	467	CB	LYS	G	85	20.987	−16.487	11.619	1.00	12.41		C
  ATOM	468	CG	LYS	G	85	20.087	−15.857	10.568	1.00	12.26		C
  ATOM	469	CD	LYS	G	85	19.083	−14.900	11.189	1.00	12.72		C
  ATOM	470	CE	LYS	G	85	19.772	−13.667	11.750	1.00	14.40		C
  ATOM	471	NZ	LYS	G	85	18.789	−12.676	12.268	1.00	16.45		N
  ATOM	472	C	LYS	G	85	23.147	−16.409	10.353	1.00	11.85		C
  ATOM	473	O	LYS	G	85	23.143	−16.238	9.125	1.00	11.66		O
  ATOM	474	N	TYR	G	86	24.031	−15.839	11.165	1.00	11.32		N
  ATOM	475	CA	TYR	G	86	25.051	−14.936	10.665	1.00	11.07		C
  ATOM	476	CB	TYR	G	86	25.863	−14.349	11.820	1.00	11.12		C
  ATOM	477	CG	TYR	G	86	27.216	−13.824	11.399	1.00	11.30		C
  ATOM	478	CD1	TYR	G	86	27.349	−12.561	10.838	1.00	12.16		C
  ATOM	479	CE1	TYR	G	86	28.584	−12.080	10.449	1.00	12.39		C
  ATOM	480	CZ	TYR	G	86	29.705	−12.864	10.619	1.00	12.62		C
  ATOM	481	OH	TYR	G	86	30.938	−12.388	10.233	1.00	12.72		O
  ATOM	482	CE2	TYR	G	86	29.599	−14.121	11.172	1.00	11.38		C
  ATOM	483	CD2	TYR	G	86	28.360	−14.595	11.558	1.00	11.05		C
  ATOM	484	C	TYR	G	86	25.971	−15.667	9.708	1.00	10.75		C
  ATOM	485	O	TYR	G	86	26.320	−15.140	8.656	1.00	10.45		O
  ATOM	486	N	LYS	G	87	26.343	−16.894	10.053	1.00	10.66		N
  ATOM	487	CA	LYS	G	87	27.220	−17.656	9.174	1.00	11.03		C
  ATOM	488	CB	LYS	G	87	27.588	−18.996	9.813	1.00	11.36		C
  ATOM	489	CG	LYS	G	87	28.300	−18.874	11.149	1.00	12.79		C
  ATOM	490	CD	LYS	G	87	28.627	−20.242	11.722	1.00	14.76		C
  ATOM	491	CE	LYS	G	87	29.336	−20.123	13.060	1.00	15.29		C
  ATOM	492	NZ	LYS	G	87	29.664	−21.460	13.626	1.00	16.27		N
  ATOM	493	C	LYS	G	87	26.541	−17.891	7.826	1.00	10.83		C
  ATOM	494	O	LYS	G	87	27.163	−17.715	6.758	1.00	11.11		O
  ATOM	495	N	ASN	G	88	25.256	−18.243	7.858	1.00	10.52		N
  ATOM	496	CA	ASN	G	88	24.567	−18.464	6.584	1.00	10.21		C
  ATOM	497	CB	ASN	G	88	23.149	−18.989	6.821	1.00	10.61		C
  ATOM	498	CG	ASN	G	88	22.406	−19.271	5.529	1.00	11.81		C
  ATOM	499	OD1	ASN	G	88	22.998	−19.285	4.450	1.00	12.97		O
  ATOM	500	ND2	ASN	G	88	21.101	−19.496	5.633	1.00	13.82		N
  ATOM	501	C	ASN	G	88	24.528	−17.187	5.730	1.00	9.42		C
  ATOM	502	O	ASN	G	88	24.780	−17.206	4.500	1.00	8.94		O
  ATOM	503	N	ALA	G	89	24.251	−16.068	6.395	1.00	8.77		N
  ATOM	504	CA	ALA	G	89	24.164	−14.796	5.693	1.00	8.21		C
  ATOM	505	CB	ALA	G	89	23.734	−13.693	6.647	1.00	7.99		C
  ATOM	506	C	ALA	G	89	25.510	−14.465	5.063	1.00	7.78		C
  ATOM	507	O	ALA	G	89	25.586	−13.988	3.927	1.00	7.88		O
  ATOM	508	N	VAL	G	90	26.574	−14.738	5.809	1.00	7.01		N
  ATOM	509	CA	VAL	G	90	27.921	−14.464	5.344	1.00	6.26		C
  ATOM	510	CB	VAL	G	90	28.965	−14.771	6.433	1.00	5.91		C
  ATOM	511	CG1	VAL	G	90	30.361	−14.414	5.945	1.00	5.92		C
  ATOM	512	CG2	VAL	G	90	28.631	−14.020	7.714	1.00	5.26		C
  ATOM	513	C	VAL	G	90	28.240	−15.284	4.104	1.00	6.25		C
  ATOM	514	O	VAL	G	90	28.798	−14.758	3.144	1.00	6.32		O
  ATOM	515	N	THR	G	91	27.858	−16.558	4.098	1.00	6.24		N
  ATOM	516	CA	THR	G	91	28.129	−17.376	2.915	1.00	6.68		C
  ATOM	517	CB	THR	G	91	27.705	−18.840	3.129	1.00	6.62		C
  ATOM	518	OG1	THR	G	91	28.438	−19.397	4.227	1.00	7.19		O
  ATOM	519	CG2	THR	G	91	27.971	−19.661	1.876	1.00	7.27		C
  ATOM	520	C	THR	G	91	27.392	−16.808	1.698	1.00	7.02		C
  ATOM	521	O	THR	G	91	27.953	−16.709	0.569	1.00	7.16		O
  ATOM	522	N	GLU	G	92	26.143	−16.402	1.925	1.00	7.31		N
  ATOM	523	CA	GLU	G	92	25.382	−15.849	0.812	1.00	7.81		C
  ATOM	524	CB	GLU	G	92	23.942	−15.547	1.231	1.00	8.23		C
  ATOM	525	CG	GLU	G	92	23.030	−16.761	1.222	1.00	10.91		C
  ATOM	526	CD	GLU	G	92	22.895	−17.372	−0.161	1.00	14.95		C
  ATOM	527	OE1	GLU	G	92	21.801	−17.878	−0.489	1.00	16.14		O
  ATOM	528	OE2	GLU	G	92	23.884	−17.346	−0.923	1.00	16.53		O
  ATOM	529	C	GLU	G	92	26.053	−14.587	0.267	1.00	7.47		C
  ATOM	530	O	GLU	G	92	26.210	−14.432	−0.947	1.00	7.32		O
  ATOM	531	N	LEU	G	93	26.501	−13.717	1.167	1.00	7.30		N
  ATOM	532	CA	LEU	G	93	27.140	−12.467	0.759	1.00	7.47		C
  ATOM	533	CB	LEU	G	93	27.442	−11.589	1.973	1.00	7.15		C
  ATOM	534	CG	LEU	G	93	26.217	−11.021	2.692	1.00	7.20		C
  ATOM	535	CD1	LEU	G	93	26.638	−10.123	3.845	1.00	7.93		C
  ATOM	536	CD2	LEU	G	93	25.325	−10.266	1.716	1.00	6.91		C
  ATOM	537	C	LEU	G	93	28.414	−12.761	−0.020	1.00	7.89		C
  ATOM	538	O	LEU	G	93	28.746	−12.083	−0.991	1.00	7.94		O
  ATOM	539	N	GLN	G	94	29.116	−13.789	0.434	1.00	8.31		N
  ATOM	540	CA	GLN	G	94	30.361	−14.248	−0.160	1.00	9.05		C
  ATOM	541	CB	GLN	G	94	30.985	−15.349	0.701	1.00	9.18		C
  ATOM	542	CG	GLN	G	94	31.324	−14.908	2.114	1.00	10.79		C
  ATOM	543	CD	GLN	G	94	31.993	−16.003	2.920	1.00	13.82		C
  ATOM	544	OE1	GLN	G	94	32.210	−17.109	2.427	1.00	14.98		O
  ATOM	545	NE2	GLN	G	94	32.324	−15.698	4.170	1.00	15.25		N
  ATOM	546	C	GLN	G	94	30.220	−14.731	−1.603	1.00	9.25		C
  ATOM	547	O	GLN	G	94	31.124	−14.514	−2.410	1.00	9.43		O
  ATOM	548	N	LEU	G	95	29.114	−15.393	−1.941	1.00	9.55		N
  ATOM	549	CA	LEU	G	95	29.003	−15.935	−3.318	1.00	10.17		C
  ATOM	550	CB	LEU	G	95	27.752	−16.811	−3.437	1.00	9.79		C
  ATOM	551	CG	LEU	G	95	27.700	−18.053	−2.545	1.00	8.86		C
  ATOM	552	CD1	LEU	G	95	26.403	−18.817	−2.764	1.00	8.31		C
  ATOM	553	CD2	LEU	G	95	28.904	−18.947	−2.798	1.00	7.62		C
  ATOM	554	C	LEU	G	95	29.057	−14.945	−4.528	1.00	11.22		C
  ATOM	555	O	LEU	G	95	29.643	−15.248	−5.567	1.00	11.55		O
  ATOM	556	N	LEU	G	96	28.430	−13.786	−4.361	1.00	12.40		N
  ATOM	557	CA	LEU	G	96	28.142	−12.747	−5.335	1.00	13.66		C
  ATOM	558	CB	LEU	G	96	27.471	−11.548	−4.668	1.00	13.38		C
  ATOM	559	CG	LEU	G	96	26.008	−11.779	−4.288	1.00	13.32		C
  ATOM	560	CD1	LEU	G	96	25.321	−10.462	−3.975	1.00	12.84		C
  ATOM	561	CD2	LEU	G	96	25.278	−12.519	−5.397	1.00	13.38		C
  ATOM	562	C	LEU	G	96	29.392	−12.314	−6.094	1.00	14.97		C
  ATOM	563	O	LEU	G	96	29.293	−11.741	−7.178	1.00	15.21		O
  ATOM	564	N	MET	G	97	30.564	−12.678	−5.576	1.00	16.74		N
  ATOM	565	CA	MET	G	97	31.799	−11.956	−5.894	1.00	18.96		C
  ATOM	566	CB	MET	G	97	32.828	−12.102	−4.766	1.00	19.12		C
  ATOM	567	CG	MET	G	97	32.353	−11.577	−3.413	1.00	21.87		C
  ATOM	568	SD	MET	G	97	32.586	−9.794	−3.210	1.00	27.46		S
  ATOM	569	CE	MET	G	97	32.408	−9.214	−4.899	1.00	24.25		C
  ATOM	570	C	MET	G	97	32.408	−12.377	−7.233	1.00	20.09		C
  ATOM	571	O	MET	G	97	33.064	−11.581	−7.905	1.00	20.58		O
  ATOM	572	N	GLN	G	98	32.151	−13.618	−7.634	1.00	21.33		N
  ATOM	573	CA	GLN	G	98	32.735	−14.171	−8.853	1.00	22.21		C
  ATOM	574	CB	GLN	G	98	33.777	−15.243	−8.513	1.00	22.53		C
  ATOM	575	CG	GLN	G	98	34.695	−14.883	−7.347	1.00	23.85		C
  ATOM	576	CD	GLN	G	98	34.172	−15.376	−6.008	1.00	25.21		C
  ATOM	577	OE1	GLN	G	98	33.109	−14.957	−5.549	1.00	24.47		O
  ATOM	578	NE2	GLN	G	98	34.939	−16.243	−5.358	1.00	24.85		N
  ATOM	579	C	GLN	G	98	31.660	−14.756	−9.766	1.00	22.15		C
  ATOM	580	O	GLN	G	98	30.475	−14.451	−9.624	1.00	21.77		O
  ATOM	581	N	PHE	G	137	36.645	−13.585	−16.969	1.00	33.25		N
  ATOM	582	CA	PHE	G	137	35.365	−12.919	−16.764	1.00	36.79		C
  ATOM	583	CB	PHE	G	137	35.255	−11.672	−17.642	1.00	20.00		C
  ATOM	584	CG	PHE	G	137	36.265	−10.611	−17.319	1.00	20.00		C
  ATOM	585	CD1	PHE	G	137	36.015	−9.677	−16.331	1.00	20.00		C
  ATOM	586	CE1	PHE	G	137	36.932	−8.682	−16.050	1.00	20.00		C
  ATOM	587	CZ	PHE	G	137	38.108	−8.607	−16.766	1.00	20.00		C
  ATOM	588	CE2	PHE	G	137	38.362	−9.523	−17.764	1.00	20.00		C
  ATOM	589	CD2	PHE	G	137	37.439	−10.510	−18.045	1.00	20.00		C
  ATOM	590	C	PHE	G	137	34.195	−13.850	−17.063	1.00	48.73		C
  ATOM	591	O	PHE	G	137	33.039	−13.434	−16.993	1.00	49.28		O
  ATOM	592	N	LEU	G	138	34.498	−15.040	−17.571	1.00	42.04		N
  ATOM	593	CA	LEU	G	138	33.471	−16.059	−17.783	1.00	44.26		C
  ATOM	594	CB	LEU	G	138	34.037	−17.258	−18.553	1.00	20.00		C
  ATOM	595	CG	LEU	G	138	34.341	−17.114	−20.050	1.00	20.00		C
  ATOM	596	CD1	LEU	G	138	34.975	−18.387	−20.605	1.00	20.00		C
  ATOM	597	CD2	LEU	G	138	33.095	−16.756	−20.843	1.00	20.00		C
  ATOM	598	C	LEU	G	138	32.896	−16.527	−16.451	1.00	43.68		C
  ATOM	599	O	LEU	G	138	31.839	−17.157	−16.406	1.00	50.27		O
  ATOM	600	N	GLY	G	139	33.614	−16.234	−15.370	1.00	38.56		N
  ATOM	601	CA	GLY	G	139	33.145	−16.544	−14.022	1.00	47.99		C
  ATOM	602	C	GLY	G	139	31.826	−15.881	−13.662	1.00	44.53		C
  ATOM	603	O	GLY	G	139	31.082	−16.383	−12.819	1.00	32.21		O
  ATOM	604	N	PHE	G	140	31.510	−14.778	−14.337	1.00	46.33		N
  ATOM	605	CA	PHE	G	140	30.319	−13.992	−14.021	1.00	42.95		C
  ATOM	606	CB	PHE	G	140	30.530	−12.516	−14.386	1.00	20.00		C
  ATOM	607	CG	PHE	G	140	31.590	−11.827	−13.564	1.00	20.00		C
  ATOM	608	CD1	PHE	G	140	31.295	−11.318	−12.310	1.00	20.00		C
  ATOM	609	CE1	PHE	G	140	32.272	−10.683	−11.553	1.00	20.00		C
  ATOM	610	CZ	PHE	G	140	33.540	−10.511	−12.066	1.00	20.00		C
  ATOM	611	CE2	PHE	G	140	33.832	−10.970	−13.334	1.00	20.00		C
  ATOM	612	CD2	PHE	G	140	32.851	−11.591	−14.090	1.00	20.00		C
  ATOM	613	C	PHE	G	140	29.077	−14.525	−14.731	1.00	38.13		C
  ATOM	614	O	PHE	G	140	27.970	−14.040	−14.504	1.00	57.33		O
  ATOM	615	N	LEU	G	141	29.271	−15.480	−15.634	1.00	35.20		N
  ATOM	616	CA	LEU	G	141	28.173	−15.996	−16.446	1.00	27.01		C
  ATOM	617	CB	LEU	G	141	26.983	−16.392	−15.560	1.00	20.00		C
  ATOM	618	CG	LEU	G	141	27.185	−17.555	−14.580	1.00	20.00		C
  ATOM	619	CD1	LEU	G	141	25.930	−17.779	−13.747	1.00	20.00		C
  ATOM	620	CD2	LEU	G	141	27.588	−18.835	−15.306	1.00	20.00		C
  ATOM	621	C	LEU	G	141	27.750	−14.978	−17.504	1.00	35.79		C
  ATOM	622	O	LEU	G	141	28.543	−14.613	−18.370	1.00	46.92		O
  ATOM	623	N	LEU	G	142	26.509	−14.508	−17.424	1.00	38.67		N
  ATOM	624	CA	LEU	G	142	26.075	−13.372	−18.231	1.00	33.84		C
  ATOM	625	CB	LEU	G	142	24.737	−13.667	−18.914	1.00	20.00		C
  ATOM	626	CG	LEU	G	142	24.720	−14.676	−20.063	1.00	20.00		C
  ATOM	627	CD1	LEU	G	142	23.339	−14.707	−20.705	1.00	20.00		C
  ATOM	628	CD2	LEU	G	142	25.773	−14.324	−21.101	1.00	20.00		C
  ATOM	629	C	LEU	G	142	25.959	−12.123	−17.368	1.00	36.89		C
  ATOM	630	O	LEU	G	142	25.257	−12.119	−16.358	1.00	45.42		O
  ATOM	631	N	GLY	G	143	26.763	−11.115	−17.688	1.00	26.84		N
  ATOM	632	CA	GLY	G	143	26.817	−9.895	−16.892	1.00	27.41		C
  ATOM	633	C	GLY	G	143	26.590	−8.645	−17.722	1.00	29.08		C
  ATOM	634	O	GLY	G	143	26.918	−8.603	−18.908	1.00	40.24		O
  ATOM	635	N	VAL	G	144	26.026	−7.622	−17.092	1.00	30.17		N
  ATOM	636	CA	VAL	G	144	25.849	−6.331	−17.739	1.00	34.15		C
  ATOM	637	CB	VAL	G	144	24.768	−5.496	−17.035	1.00	20.00		C
  ATOM	638	CG1	VAL	G	144	24.730	−4.081	−17.599	1.00	20.00		C
  ATOM	639	CG2	VAL	G	144	23.414	−6.166	−17.170	1.00	20.00		C
  ATOM	640	C	VAL	G	144	27.152	−5.543	−17.760	1.00	36.67		C
  ATOM	641	O	VAL	G	144	28.104	−5.880	−17.054	1.00	42.49		O
  ATOM	642	N	GLY	G	145	27.185	−4.487	−18.567	1.00	47.09		N
  ATOM	643	CA	GLY	G	145	28.309	−3.563	−18.568	1.00	44.51		C
  ATOM	644	C	GLY	G	145	28.683	−3.184	−17.151	1.00	44.94		C
  ATOM	645	O	GLY	G	145	29.809	−3.424	−16.714	1.00	40.58		O
  ATOM	646	N	SER	G	146	27.732	−2.662	−16.387	1.00	42.06		N
  ATOM	647	CA	SER	G	146	28.033	−2.190	−15.035	1.00	47.39		C
  ATOM	648	CB	SER	G	146	26.797	−1.534	−14.414	1.00	20.00		C
  ATOM	649	OG	SER	G	146	25.719	−2.450	−14.333	1.00	20.00		O
  ATOM	650	C	SER	G	146	28.570	−3.280	−14.101	1.00	51.48		C
  ATOM	651	O	SER	G	146	29.491	−3.034	−13.317	1.00	47.45		O
  ATOM	652	N	ALA	G	147	28.004	−4.480	−14.183	1.00	39.51		N
  ATOM	653	CA	ALA	G	147	28.430	−5.576	−13.316	1.00	43.38		C
  ATOM	654	CB	ALA	G	147	27.531	−6.788	−13.513	1.00	20.00		C
  ATOM	655	C	ALA	G	147	29.894	−5.954	−13.541	1.00	47.39		C
  ATOM	656	O	ALA	G	147	30.635	−6.211	−12.587	1.00	50.18		O
  ATOM	657	N	ILE	G	148	30.309	−5.983	−14.804	1.00	44.67		N
  ATOM	658	CA	ILE	G	148	31.690	−6.311	−15.140	1.00	43.56		C
  ATOM	659	CB	ILE	G	148	31.898	−6.390	−16.663	1.00	20.00		C
  ATOM	660	CG1	ILE	G	148	30.998	−7.469	−17.269	1.00	20.00		C
  ATOM	661	CD1	ILE	G	148	31.142	−7.612	−18.768	1.00	20.00		C
  ATOM	662	CG2	ILE	G	148	33.358	−6.663	−16.987	1.00	20.00		C
  ATOM	663	C	ILE	G	148	32.633	−5.265	−14.558	1.00	51.18		C
  ATOM	664	O	ILE	G	148	33.699	−5.592	−14.031	1.00	39.17		O
  ATOM	665	N	ALA	G	149	32.226	−4.003	−14.651	1.00	42.17		N
  ATOM	666	CA	ALA	G	149	33.020	−2.906	−14.116	1.00	36.76		C
  ATOM	667	CB	ALA	G	149	32.386	−1.571	−14.466	1.00	20.00		C
  ATOM	668	C	ALA	G	149	33.150	−3.058	−12.607	1.00	45.19		C
  ATOM	669	O	ALA	G	149	34.222	−2.843	−12.041	1.00	47.83		O
  ATOM	670	N	SER	G	150	32.054	−3.443	−11.961	1.00	43.64		N
  ATOM	671	CA	SER	G	150	32.062	−3.643	−10.518	1.00	43.46		C
  ATOM	672	CB	SER	G	150	30.657	−3.968	−10.010	1.00	20.00		C
  ATOM	673	OG	SER	G	150	30.165	−5.160	−10.596	1.00	20.00		O
  ATOM	674	C	SER	G	150	33.030	−4.762	−10.146	1.00	44.80		C
  ATOM	675	O	SER	G	150	33.774	−4.653	−9.170	1.00	41.55		O
  ATOM	676	N	GLY	G	151	33.025	−5.833	−10.935	1.00	27.01		N
  ATOM	677	CA	GLY	G	151	33.927	−6.946	−10.697	1.00	35.21		C
  ATOM	678	C	GLY	G	151	35.376	−6.519	−10.839	1.00	42.40		C
  ATOM	679	O	GLY	G	151	36.246	−6.924	−10.055	1.00	45.11		O
  ATOM	680	N	VAL	G	152	35.638	−5.691	−11.846	1.00	40.20		N
  ATOM	681	CA	VAL	G	152	36.983	−5.185	−12.076	1.00	46.73		C
  ATOM	682	CB	VAL	G	152	37.056	−4.330	−13.354	1.00	20.00		C
  ATOM	683	CG1	VAL	G	152	38.472	−3.816	−13.568	1.00	20.00		C
  ATOM	684	CG2	VAL	G	152	36.587	−5.134	−14.557	1.00	20.00		C
  ATOM	685	C	VAL	G	152	37.424	−4.345	−10.885	1.00	48.62		C
  ATOM	686	O	VAL	G	152	38.565	−4.438	−10.432	1.00	49.32		O
  ATOM	687	N	ALA	G	153	36.502	−3.537	−10.370	1.00	35.09		N
  ATOM	688	CA	ALA	G	153	36.788	−2.690	−9.220	1.00	42.37		C
  ATOM	689	CB	ALA	G	153	35.604	−1.787	−8.918	1.00	20.00		C
  ATOM	690	C	ALA	G	153	37.120	−3.557	−8.014	1.00	37.79		C
  ATOM	691	O	ALA	G	153	38.029	−3.247	−7.243	1.00	39.25		O
  ATOM	692	N	VAL	G	154	36.378	−4.648	−7.859	1.00	38.88		N
  ATOM	693	CA	VAL	G	154	36.610	−5.579	−6.763	1.00	35.53		C
  ATOM	694	CB	VAL	G	154	35.549	−6.695	−6.737	1.00	20.00		C
  ATOM	695	CG1	VAL	G	154	35.814	−7.651	−5.584	1.00	20.00		C
  ATOM	696	CG2	VAL	G	154	34.154	−6.098	−6.634	1.00	20.00		C
  ATOM	697	C	VAL	G	154	37.996	−6.209	−6.863	1.00	41.00		C
  ATOM	698	O	VAL	G	154	38.690	−6.353	−5.856	1.00	50.08		O
  ATOM	699	N	SER	G	155	38.403	−6.579	−8.075	1.00	37.82		N
  ATOM	700	CA	SER	G	155	39.733	−7.158	−8.271	1.00	44.68		C
  ATOM	701	CB	SER	G	155	39.906	−7.630	−9.715	1.00	20.00		C
  ATOM	702	OG	SER	G	155	39.757	−6.554	−10.625	1.00	20.00		O
  ATOM	703	C	SER	G	155	40.817	−6.140	−7.914	1.00	41.82		C
  ATOM	704	O	SER	G	155	41.834	−6.468	−7.304	1.00	49.37		O
  ATOM	705	N	LYS	G	156	40.566	−4.900	−8.314	1.00	36.99		N
  ATOM	706	CA	LYS	G	156	41.440	−3.756	−8.097	1.00	35.11		C
  ATOM	707	CB	LYS	G	156	40.989	−2.562	−8.943	1.00	20.00		C
  ATOM	708	CG	LYS	G	156	41.146	−2.767	−10.443	1.00	20.00		C
  ATOM	709	CD	LYS	G	156	40.541	−1.606	−11.227	1.00	20.00		C
  ATOM	710	CE	LYS	G	156	40.906	−1.679	−12.708	1.00	20.00		C
  ATOM	711	NZ	LYS	G	156	40.298	−0.569	−13.497	1.00	20.00		N
  ATOM	712	C	LYS	G	156	41.489	−3.378	−6.620	1.00	35.98		C
  ATOM	713	O	LYS	G	156	42.501	−2.874	−6.136	1.00	42.31		O
  ATOM	714	N	VAL	G	157	40.433	−3.719	−5.886	1.00	37.88		N
  ATOM	715	CA	VAL	G	157	40.341	−3.361	−4.475	1.00	50.94		C
  ATOM	716	CB	VAL	G	157	38.894	−3.057	−4.061	1.00	20.00		C
  ATOM	717	CG1	VAL	G	157	38.799	−2.928	−2.551	1.00	20.00		C
  ATOM	718	CG2	VAL	G	157	38.403	−1.790	−4.745	1.00	20.00		C
  ATOM	719	C	VAL	G	157	40.882	−4.474	−3.591	1.00	47.82		C
  ATOM	720	O	VAL	G	157	41.021	−4.309	−2.379	1.00	56.87		O
  ATOM	721	N	LEU	G	158	41.279	−5.588	−4.192	1.00	39.52		N
  ATOM	722	CA	LEU	G	158	41.557	−6.817	−3.448	1.00	50.27		C
  ATOM	723	CB	LEU	G	158	41.899	−7.952	−4.419	1.00	20.00		C
  ATOM	724	CG	LEU	G	158	40.817	−8.321	−5.435	1.00	20.00		C
  ATOM	725	CD1	LEU	G	158	41.287	−9.458	−6.330	1.00	20.00		C
  ATOM	726	CD2	LEU	G	158	39.521	−8.689	−4.729	1.00	20.00		C
  ATOM	727	C	LEU	G	158	42.627	−6.743	−2.351	1.00	54.47		C
  ATOM	728	O	LEU	G	158	42.456	−7.343	−1.285	1.00	49.26		O
  ATOM	729	N	HIS	G	159	43.716	−6.021	−2.585	1.00	59.45		N
  ATOM	730	CA	HIS	G	159	44.772	−5.947	−1.579	1.00	49.11		C
  ATOM	731	CB	HIS	G	159	45.963	−5.146	−2.108	1.00	20.00		C
  ATOM	732	CG	HIS	G	159	46.583	−5.728	−3.340	1.00	20.00		C
  ATOM	733	ND1	HIS	G	159	47.606	−6.651	−3.293	1.00	20.00		N
  ATOM	734	CE1	HIS	G	159	47.951	−6.984	−4.524	1.00	20.00		C
  ATOM	735	NE2	HIS	G	159	47.189	−6.311	−5.368	1.00	20.00		N
  ATOM	736	CD2	HIS	G	159	46.325	−5.518	−4.652	1.00	20.00		C
  ATOM	737	C	HIS	G	159	44.256	−5.325	−0.280	1.00	44.09		C
  ATOM	738	O	HIS	G	159	44.572	−5.797	0.819	1.00	42.13		O
  ATOM	739	N	LEU	G		160	43.449	−4.277	−0.410	1.00	37.55		N
  ATOM	740	CA	LEU	G	160	42.876	−3.609	0.751	1.00	43.52		C
  ATOM	741	CB	LEU	G	160	42.095	−2.365	0.323	1.00	20.00		C
  ATOM	742	CG	LEU	G		160	42.891	−1.283	−0.409	1.00	20.00		C
  ATOM	743	CD1	LEU	G	160	41.996	−0.107	−0.769	1.00	20.00		C
  ATOM	744	CD2	LEU	G	160	44.073	−0.825	0.432	1.00	20.00		C
  ATOM	745	C	LEU	G	160	41.966	−4.559	1.523	1.00	47.22		C
  ATOM	746	O	LEU	G		160	41.969	−4.578	2.756	1.00	43.25		O
  ATOM	747	N	GLU	G	161	41.190	−5.350	0.788	1.00	40.88		N
  ATOM	748	CA	GLU	G	161	40.292	−6.318	1.402	1.00	40.61		C
  ATOM	749	CB	GLU	G	161	39.434	−7.005	0.338	1.00	20.00		C
  ATOM	750	CG	GLU	G	161	38.558	−6.055	−0.462	1.00	20.00		C
  ATOM	751	CD	GLU	G	161	37.719	−6.773	−1.501	1.00	20.00		C
  ATOM	752	OE1	GLU	G	161	36.959	−6.094	−2.224	1.00	20.00		O
  ATOM	753	OE2	GLU	G	161	37.819	−8.014	−1.596	1.00	20.00		O
  ATOM	754	C	GLU	G	161	41.097	−7.352	2.179	1.00	39.76		C
  ATOM	755	O	GLU	G	161	40.720	−7.747	3.284	1.00	44.02		O
  ATOM	756	N	GLY	G	162	42.213	−7.781	1.599	1.00	34.18		N
  ATOM	757	CA	GLY	G	162	43.079	−8.742	2.256	1.00	35.01		C
  ATOM	758	C	GLY	G	162	43.637	−8.163	3.542	1.00	34.86		C
  ATOM	759	O	GLY	G	162	43.706	−8.844	4.570	1.00	47.81		O
  ATOM	760	N	GLU	G	163	44.019	−6.890	3.489	1.00	40.78		N
  ATOM	761	CA	GLU	G	163	44.546	−6.213	4.669	1.00	37.20		C
  ATOM	762	CB	GLU	G	163	45.016	−4.801	4.315	1.00	20.00		C
  ATOM	763	CG	GLU	G	163	46.112	−4.758	3.264	1.00	20.00		C
  ATOM	764	CD	GLU	G	163	46.555	−3.345	2.942	1.00	20.00		C
  ATOM	765	OE1	GLU	G	163	47.454	−3.181	2.090	1.00	20.00		O
  ATOM	766	OE2	GLU	G	163	46.003	−2.399	3.540	1.00	20.00		O
  ATOM	767	C	GLU	G	163	43.480	−6.158	5.758	1.00	46.12		C
  ATOM	768	O	GLU	G	163	43.770	−6.363	6.939	1.00	58.66		O
  ATOM	769	N	VAL	G	164	42.243	−5.885	5.354	1.00	42.23		N
  ATOM	770	CA	VAL	G	164	41.129	−5.833	6.292	1.00	35.45		C
  ATOM	771	CB	VAL	G	164	39.827	−5.387	5.602	1.00	20.00		C
  ATOM	772	CG1	VAL	G	164	38.684	−5.343	6.604	1.00	20.00		C
  ATOM	773	CG2	VAL	G	164	40.015	−4.032	4.937	1.00	20.00		C
  ATOM	774	C	VAL	G	164	40.908	−7.195	6.947	1.00	46.32		C
  ATOM	775	O	VAL	G	164	40.656	−7.284	8.153	1.00	45.08		O
  ATOM	776	N	ASN	G	165	41.011	−8.257	6.151	1.00	40.82		N
  ATOM	777	CA	ASN	G	165	40.854	−9.603	6.687	1.00	46.48		C
  ATOM	778	CB	ASN	G	165	40.897	−10.652	5.573	1.00	20.00		C
  ATOM	779	CG	ASN	G	165	39.710	−10.560	4.634	1.00	20.00		C
  ATOM	780	OD1	ASN	G	165	38.643	−11.108	4.909	1.00	20.00		O
  ATOM	781	ND2	ASN	G	165	39.896	−9.881	3.509	1.00	20.00		N
  ATOM	782	C	ASN	G	165	41.947	−9.884	7.708	1.00	50.90		C
  ATOM	783	O	ASN	G	165	41.694	−10.455	8.769	1.00	47.11		O
  ATOM	784	N	LYS	G	166	43.161	−9.451	7.385	1.00	48.36		N
  ATOM	785	CA	LYS	G	166	44.305	−9.640	8.269	1.00	38.71		C
  ATOM	786	CB	LYS	G	166	45.591	−9.154	7.595	1.00	20.00		C
  ATOM	787	CG	LYS	G	166	45.907	−9.850	6.277	1.00	20.00		C
  ATOM	788	CD	LYS	G	166	47.180	−9.298	5.649	1.00	20.00		C
  ATOM	789	CE	LYS	G	166	47.495	−9.990	4.331	1.00	20.00		C
  ATOM	790	NZ	LYS	G	166	48.735	−9.455	3.701	1.00	20.00		N
  ATOM	791	C	LYS	G	166	44.090	−8.907	9.591	1.00	45.07		C
  ATOM	792	O	LYS	G	166	44.459	−9.402	10.657	1.00	56.09		O
  ATOM	793	N	ILE	G	167	43.491	−7.725	9.508	1.00	42.02		N
  ATOM	794	CA	ILE	G	167	43.256	−6.876	10.673	1.00	43.86		C
  ATOM	795	CB	ILE	G	167	43.338	−5.380	10.304	1.00	20.00		C
  ATOM	796	CG1	ILE	G	167	44.721	−5.042	9.743	1.00	20.00		C
  ATOM	797	CD1	ILE	G	167	44.884	−3.589	9.349	1.00	20.00		C
  ATOM	798	CG2	ILE	G	167	43.025	−4.514	11.516	1.00	20.00		C
  ATOM	799	C	ILE	G	167	41.921	−7.143	11.377	1.00	49.02		C
  ATOM	800	O	ILE	G	167	41.570	−6.443	12.327	1.00	37.71		O
  ATOM	801	N	LYS	G	168	41.175	−8.142	10.911	1.00	33.87		N
  ATOM	802	CA	LYS	G	168	39.851	−8.426	11.471	1.00	35.11		C
  ATOM	803	CB	LYS	G	168	39.163	−9.533	10.667	1.00	20.00		C
  ATOM	804	CG	LYS	G	168	38.874	−9.175	9.219	1.00	20.00		C
  ATOM	805	CD	LYS	G	168	38.101	−10.286	8.524	1.00	20.00		C
  ATOM	806	CE	LYS	G	168	37.755	−9.909	7.092	1.00	20.00		C
  ATOM	807	NZ	LYS	G	168	36.921	−10.950	6.427	1.00	20.00		N
  ATOM	808	C	LYS	G	168	39.820	−8.790	12.966	1.00	39.27		C
  ATOM	809	O	LYS	G	168	38.932	−8.339	13.690	1.00	32.39		O
  ATOM	810	N	SER	G	169	40.770	−9.599	13.428	1.00	41.30		N
  ATOM	811	CA	SER	G	169	40.805	−10.008	14.827	1.00	43.23		C
  ATOM	812	CB	SER	G	169	42.030	−10.884	15.100	1.00	20.00		C
  ATOM	813	OG	SER	G	169	43.231	−10.175	14.847	1.00	20.00		O
  ATOM	814	C	SER	G	169	40.796	−8.806	15.767	1.00	41.44		C
  ATOM	815	O	SER	G	169	40.016	−8.759	16.718	1.00	44.82		O
  ATOM	816	N	ALA	G	170	41.695	−7.857	15.522	1.00	39.78		N
  ATOM	817	CA	ALA	G	170	41.753	−6.638	16.319	1.00	41.01		C
  ATOM	818	CB	ALA	G	170	42.928	−5.775	15.887	1.00	20.00		C
  ATOM	819	C	ALA	G	170	40.448	−5.857	16.211	1.00	46.04		C
  ATOM	820	O	ALA	G	170	39.912	−5.381	17.211	1.00	46.67		O
  ATOM	821	N	LEU	G	171	39.921	−5.766	14.995	1.00	34.26		N
  ATOM	822	CA	LEU	G	171	38.642	−5.108	14.762	1.00	37.69		C
  ATOM	823	CB	LEU	G	171	38.269	−5.179	13.280	1.00	20.00		C
  ATOM	824	CG	LEU	G	171	39.239	−4.485	12.323	1.00	20.00		C
  ATOM	825	CD1	LEU	G	171	38.764	−4.625	10.881	1.00	20.00		C
  ATOM	826	CD2	LEU	G	171	39.417	−3.022	12.711	1.00	20.00		C
  ATOM	827	C	LEU	G	171	37.534	−5.723	15.616	1.00	44.67		C
  ATOM	828	O	LEU	G	171	36.683	−5.010	16.151	1.00	34.27		O
  ATOM	829	N	LEU	G	172	37.577	−7.043	15.776	1.00	34.80		N
  ATOM	830	CA	LEU	G	172	36.536	−7.765	16.498	1.00	28.87		C
  ATOM	831	CB	LEU	G	172	36.606	−9.258	16.179	1.00	20.00		C
  ATOM	832	CG	LEU	G	172	36.254	−9.646	14.744	1.00	20.00		C
  ATOM	833	CD1	LEU	G	172	36.412	−11.143	14.539	1.00	20.00		C
  ATOM	834	CD2	LEU	G	172	34.842	−9.201	14.414	1.00	20.00		C
  ATOM	835	C	LEU	G	172	36.655	−7.547	18.001	1.00	29.90		C
  ATOM	836	O	LEU	G	172	35.650	−7.435	18.704	1.00	41.09		O
  ATOM	837	N	SER	G	173	37.889	−7.498	18.490	1.00	35.08		N
  ATOM	838	CA	SER	G	173	38.139	−7.406	19.923	1.00	35.53		C
  ATOM	839	CB	SER	G	173	39.578	−7.823	20.245	1.00	20.00		C
  ATOM	840	OG	SER	G	173	40.515	−7.012	19.556	1.00	20.00		O
  ATOM	841	C	SER	G	173	37.860	−5.999	20.450	1.00	35.07		C
  ATOM	842	O	SER	G	173	37.581	−5.815	21.636	1.00	51.28		O
  ATOM	843	N	THR	G	174	37.893	−5.021	19.550	1.00	46.35		N
  ATOM	844	CA	THR	G	174	37.721	−3.621	19.922	1.00	43.83		C
  ATOM	845	CB	THR	G	174	38.341	−2.681	18.860	1.00	20.00		C
  ATOM	846	OG1	THR	G	174	37.702	−2.897	17.595	1.00	20.00		O
  ATOM	847	CG2	THR	G	174	39.839	−2.940	18.719	1.00	20.00		C
  ATOM	848	C	THR	G	174	36.236	−3.300	20.083	1.00	52.54		C
  ATOM	849	O	THR	G	174	35.448	−3.528	19.165	1.00	64.10		O
  ATOM	850	N	ASN	G	175	35.839	−2.919	21.295	1.00	55.57		N
  ATOM	851	CA	ASN	G	175	34.501	−2.371	21.528	1.00	40.58		C
  ATOM	852	CB	ASN	G	175	34.109	−2.499	23.005	1.00	20.00		C
  ATOM	853	CG	ASN	G	175	33.819	−3.933	23.416	1.00	20.00		C
  ATOM	854	OD1	ASN	G	175	33.530	−4.786	22.578	1.00	20.00		O
  ATOM	855	ND2	ASN	G	175	33.845	−4.190	24.720	1.00	20.00		N
  ATOM	856	C	ASN	G	175	34.404	−0.909	21.089	1.00	43.65		C
  ATOM	857	O	ASN	G	175	35.035	−0.032	21.682	1.00	53.11		O
  ATOM	858	N	LYS	G	176	33.694	−0.671	19.990	1.00	44.89		N
  ATOM	859	CA	LYS	G	176	33.519	0.680	19.463	1.00	46.42		C
  ATOM	860	CB	LYS	G	176	34.847	1.244	18.945	1.00	20.00		C
  ATOM	861	CG	LYS	G	176	35.789	1.756	20.031	1.00	20.00		C
  ATOM	862	CD	LYS	G	176	37.220	1.872	19.511	1.00	20.00		C
  ATOM	863	CE	LYS	G	176	38.243	1.433	20.560	1.00	20.00		C
  ATOM	864	NZ	LYS	G	176	39.542	1.012	19.953	1.00	20.00		N
  ATOM	865	C	LYS	G	176	32.478	0.701	18.352	1.00	45.00		C
  ATOM	866	O	LYS	G	176	32.405	−0.217	17.534	1.00	60.64		O
  ATOM	867	N	ALA	G	177	31.674	1.756	18.330	1.00	46.01		N
  ATOM	868	CA	ALA	G	177	30.717	1.962	17.257	1.00	43.65		C
  ATOM	869	CB	ALA	G	177	29.708	3.027	17.652	1.00	20.00		C
  ATOM	870	C	ALA	G	177	31.437	2.359	15.977	1.00	41.42		C
  ATOM	871	O	ALA	G	177	31.168	1.813	14.907	1.00	45.37		O
  ATOM	872	N	VAL	G	178	32.360	3.308	16.097	1.00	35.70		N
  ATOM	873	CA	VAL	G	178	33.228	3.683	14.987	1.00	43.93		C
  ATOM	874	CB	VAL	G	178	32.876	5.083	14.432	1.00	20.00		C
  ATOM	875	CG1	VAL	G	178	33.896	5.516	13.379	1.00	20.00		C
  ATOM	876	CG2	VAL	G	178	31.463	5.090	13.860	1.00	20.00		C
  ATOM	877	C	VAL	G	178	34.685	3.676	15.427	1.00	34.16		C
  ATOM	878	O	VAL	G	178	35.005	4.063	16.550	1.00	44.45		O
  ATOM	879	N	VAL	G	179	35.560	3.200	14.550	1.00	44.87		N
  ATOM	880	CA	VAL	G	179	36.972	3.080	14.884	1.00	38.47		C
  ATOM	881	CB	VAL	G	179	37.255	1.806	15.696	1.00	20.00		C
  ATOM	882	CG1	VAL	G	179	38.742	1.679	15.986	1.00	20.00		C
  ATOM	883	CG2	VAL	G	179	36.457	1.817	16.984	1.00	20.00		C
  ATOM	884	C	VAL	G	179	37.855	3.091	13.643	1.00	44.79		C
  ATOM	885	O	VAL	G	179	37.560	2.423	12.650	1.00	51.88		O
  ATOM	886	N	SER	G	180	38.955	3.835	13.719	1.00	45.23		N
  ATOM	887	CA	SER	G	180	39.937	3.871	12.643	1.00	48.99		C
  ATOM	888	CB	SER	G	180	40.875	5.069	12.812	1.00	20.00		C
  ATOM	889	OG	SER	G	180	41.649	4.948	13.993	1.00	20.00		O
  ATOM	890	C	SER	G	180	40.740	2.577	12.610	1.00	48.15		C
  ATOM	891	O	SER	G	180	41.386	2.212	13.594	1.00	60.42		O
  ATOM	892	N	LEU	G	181	40.594	1.827	11.521	1.00	42.42		N
  ATOM	893	CA	LEU	G	181	41.389	0.622	11.302	1.00	43.22		C
  ATOM	894	CB	LEU	G	181	40.818	−0.190	10.139	1.00	20.00		C
  ATOM	895	CG	LEU	G	181	39.415	−0.753	10.350	1.00	20.00		C
  ATOM	896	CD1	LEU	G	181	38.958	−1.514	9.118	1.00	20.00		C
  ATOM	897	CD2	LEU	G	181	39.394	−1.643	11.577	1.00	20.00		C
  ATOM	898	C	LEU	G	181	42.838	0.984	11.011	1.00	29.14		C
  ATOM	899	O	LEU	G	181	43.144	1.559	9.967	1.00	43.42		O
  ATOM	900	N	SER	G	182	43.721	0.695	11.960	1.00	41.83		N
  ATOM	901	CA	SER	G	182	45.089	1.186	11.883	1.00	53.52		C
  ATOM	902	CB	SER	G	182	45.421	2.069	13.086	1.00	20.00		C
  ATOM	903	OG	SER	G	182	45.500	1.303	14.275	1.00	20.00		O
  ATOM	904	C	SER	G	182	46.110	0.063	11.741	1.00	44.76		C
  ATOM	905	O	SER	G	182	45.995	−0.984	12.379	1.00	37.73		O
  ATOM	906	N	ASN	G	183	47.028	0.245	10.799	1.00	47.84		N
  ATOM	907	CA	ASN	G	183	48.262	−0.525	10.744	1.00	59.45		C
  ATOM	908	CB	ASN	G	183	48.350	−1.276	9.412	1.00	20.00		C
  ATOM	909	CG	ASN	G	183	47.312	−2.375	9.290	1.00	20.00		C
  ATOM	910	OD1	ASN	G	183	46.897	−2.964	10.287	1.00	20.00		O
  ATOM	911	ND2	ASN	G	183	46.954	−2.715	8.057	1.00	20.00		N
  ATOM	912	C	ASN	G	183	49.445	0.428	10.872	1.00	75.41		C
  ATOM	913	O	ASN	G	183	49.386	1.559	10.391	1.00	102.31		O
  ATOM	914	N	GLY	G	184	50.463	0.021	11.624	1.00	79.30		N
  ATOM	915	CA	GLY	G	184	51.584	0.906	11.931	1.00	88.92		C
  ATOM	916	C	GLY	G	184	51.464	2.278	11.287	1.00	101.85		C
  ATOM	917	O	GLY	G	184	51.911	2.485	10.158	1.00	113.48		O
  ATOM	918	N	VAL	G	185	50.833	3.209	11.999	1.00	86.84		N
  ATOM	919	CA	VAL	G	185	50.888	4.635	11.665	1.00	81.80		C
  ATOM	920	CB	VAL	G	185	52.336	5.149	11.526	1.00	20.00		C
  ATOM	921	CG1	VAL	G	185	52.340	6.607	11.085	1.00	20.00		C
  ATOM	922	CG2	VAL	G	185	53.086	4.984	12.838	1.00	20.00		C
  ATOM	923	C	VAL	G	185	50.097	5.027	10.417	1.00	81.69		C
  ATOM	924	O	VAL	G	185	50.205	6.157	9.942	1.00	99.84		O
  ATOM	925	N	SER	G	186	49.286	4.109	9.902	1.00	70.63		N
  ATOM	926	CA	SER	G	186	48.501	4.392	8.705	1.00	72.29		C
  ATOM	927	CB	SER	G	186	49.173	3.803	7.463	1.00	20.00		C
  ATOM	928	OG	SER	G	186	49.228	2.389	7.534	1.00	20.00		O
  ATOM	929	C	SER	G	186	47.066	3.893	8.820	1.00	62.99		C
  ATOM	930	O	SER	G	186	46.820	2.769	9.258	1.00	58.35		O
  ATOM	931	N	VAL	G	187	46.122	4.736	8.415	1.00	66.49		N
  ATOM	932	CA	VAL	G	187	44.709	4.389	8.471	1.00	57.36		C
  ATOM	933	CB	VAL	G	187	43.834	5.635	8.704	1.00	20.00		C
  ATOM	934	CG1	VAL	G	187	42.371	5.248	8.769	1.00	20.00		C
  ATOM	935	CG2	VAL	G	187	44.254	6.346	9.982	1.00	20.00		C
  ATOM	936	C	VAL	G	187	44.266	3.684	7.191	1.00	53.67		C
  ATOM	937	O	VAL	G	187	44.408	4.222	6.093	1.00	50.10		O
  ATOM	938	N	LEU	G	188	43.768	2.460	7.338	1.00	43.20		N
  ATOM	939	CA	LEU	G	188	43.289	1.678	6.201	1.00	41.76		C
  ATOM	940	CB	LEU	G	188	43.404	0.183	6.495	1.00	20.00		C
  ATOM	941	CG	LEU	G	188	44.821	−0.375	6.633	1.00	20.00		C
  ATOM	942	CD1	LEU	G	188	44.777	−1.845	7.014	1.00	20.00		C
  ATOM	943	CD2	LEU	G	188	45.605	−0.174	5.345	1.00	20.00		C
  ATOM	944	C	LEU	G	188	41.843	2.021	5.862	1.00	44.75		C
  ATOM	945	O	LEU	G	188	41.384	1.777	4.746	1.00	45.28		O
  ATOM	946	N	THR	G	189	41.111	2.500	6.863	1.00	39.28		N
  ATOM	947	CA	THR	G	189	39.710	2.863	6.694	1.00	36.51		C
  ATOM	948	CB	THR	G	189	38.985	1.880	5.760	1.00	20.00		C
  ATOM	949	OG1	THR	G	189	38.871	0.604	6.400	1.00	20.00		O
  ATOM	950	CG2	THR	G	189	39.759	1.715	4.458	1.00	20.00		C
  ATOM	951	C	THR	G	189	39.006	2.891	8.046	1.00	45.83		C
  ATOM	952	O	THR	G	189	39.637	3.112	9.079	1.00	42.57		O
  ATOM	953	N	SER	G	190	37.692	2.695	8.033	1.00	40.44		N
  ATOM	954	CA	SER	G	190	36.902	2.779	9.255	1.00	41.82		C
  ATOM	955	CB	SER	G	190	35.919	3.953	9.188	1.00	20.00		C
  ATOM	956	OG	SER	G	190	34.930	3.737	8.196	1.00	20.00		O
  ATOM	957	C	SER	G	190	36.153	1.479	9.527	1.00	33.81		C
  ATOM	958	O	SER	G	190	35.609	0.860	8.611	1.00	49.61		O
  ATOM	959	N	LYS	G	191	36.134	1.069	10.791	1.00	37.37		N
  ATOM	960	CA	LYS	G	191	35.365	−0.097	11.208	1.00	41.23		C
  ATOM	961	CB	LYS	G	191	36.239	−1.047	12.027	1.00	20.00		C
  ATOM	962	CG	LYS	G	191	37.323	−1.731	11.216	1.00	20.00		C
  ATOM	963	CD	LYS	G	191	38.193	−2.623	12.085	1.00	20.00		C
  ATOM	964	CE	LYS	G	191	39.313	−3.257	11.267	1.00	20.00		C
  ATOM	965	NZ	LYS	G	191	40.316	−3.959	12.119	1.00	20.00		N
  ATOM	966	C	LYS	G	191	34.143	0.315	12.018	1.00	35.03		C
  ATOM	967	O	LYS	G	191	34.267	0.958	13.059	1.00	40.06		O
  ATOM	968	N	VAL	G	192	32.966	−0.093	11.555	1.00	33.70		N
  ATOM	969	CA	VAL	G	192	31.712	0.327	12.171	1.00	27.61		C
  ATOM	970	CB	VAL	G	192	30.816	1.081	11.173	1.00	20.00		C
  ATOM	971	CG1	VAL	G	192	29.505	1.481	11.832	1.00	20.00		C
  ATOM	972	CG2	VAL	G	192	31.540	2.293	10.617	1.00	20.00		C
  ATOM	973	C	VAL	G	192	30.929	−0.857	12.723	1.00	31.74		C
  ATOM	974	O	VAL	G	192	30.965	−1.954	12.167	1.00	25.58		O
  ATOM	975	N	LEU	G	193	30.177	−0.610	13.790	1.00	28.88		N
  ATOM	976	CA	LEU	G	193	29.272	−1.609	14.342	1.00	34.36		C
  ATOM	977	CB	LEU	G	193	29.940	−2.349	15.504	1.00	20.00		C
  ATOM	978	CG	LEU	G	193	31.127	−3.249	15.156	1.00	20.00		C
  ATOM	979	CD1	LEU	G	193	31.818	−3.743	16.418	1.00	20.00		C
  ATOM	980	CD2	LEU	G	193	30.677	−4.419	14.295	1.00	20.00		C
  ATOM	981	C	LEU	G	193	27.982	−0.950	14.818	1.00	33.03		C
  ATOM	982	O	LEU	G	193	27.963	−0.290	15.856	1.00	44.93		O
  ATOM	983	N	ASP	G	194	26.896	−1.170	14.081	1.00	35.09		N
  ATOM	984	CA	ASP	G	194	25.724	−0.298	14.150	1.00	41.39		C
  ATOM	985	CB	ASP	G	194	24.766	−0.589	12.995	1.00	20.00		C
  ATOM	986	CG	ASP	G	194	25.292	−0.090	11.667	1.00	20.00		C
  ATOM	987	OD1	ASP	G	194	26.173	0.795	11.668	1.00	20.00		O
  ATOM	988	OD2	ASP	G	194	24.863	−0.620	10.621	1.00	20.00		O
  ATOM	989	C	ASP	G	194	24.976	−0.377	15.479	1.00	38.04		C
  ATOM	990	O	ASP	G	194	24.097	0.442	15.752	1.00	48.03		O
  ATOM	991	N	LEU	G	195	25.259	−1.410	16.263	1.00	43.64		N
  ATOM	992	CA	LEU	G	195	24.463	−1.682	17.449	1.00	35.97		C
  ATOM	993	CB	LEU	G	195	23.832	−3.071	17.366	1.00	20.00		C
  ATOM	994	CG	LEU	G	195	22.988	−3.340	16.117	1.00	20.00		C
  ATOM	995	CD1	LEU	G	195	22.479	−4.773	16.112	1.00	20.00		C
  ATOM	996	CD2	LEU	G	195	21.847	−2.340	15.969	1.00	20.00		C
  ATOM	997	C	LEU	G	195	25.254	−1.525	18.744	1.00	43.63		C
  ATOM	998	O	LEU	G	195	24.675	−1.495	19.830	1.00	34.71		O
  ATOM	999	N	ASN	G	196	26.558	−1.299	18.617	1.00	44.30		N
  ATOM	1000	CA	ASN	G	196	27.458	−1.365	19.765	1.00	42.38		C
  ATOM	1001	CB	ASN	G	196	28.900	−1.082	19.342	1.00	20.00		C
  ATOM	1002	CG	ASN	G	196	29.508	−2.223	18.551	1.00	20.00		C
  ATOM	1003	OD1	ASN	G	196	29.101	−3.377	18.688	1.00	20.00		O
  ATOM	1004	ND2	ASN	G	196	30.503	−1.908	17.731	1.00	20.00		N
  ATOM	1005	C	ASN	G	196	27.041	−0.434	20.900	1.00	43.66		C
  ATOM	1006	O	ASN	G	196	26.944	−0.855	22.053	1.00	33.62		O
  ATOM	1007	N	ASN	G	197	26.706	0.806	20.560	1.00	34.31		N
  ATOM	1008	CA	ASN	G	197	26.346	1.793	21.570	1.00	38.83		C
  ATOM	1009	CB	ASN	G	197	26.089	3.153	20.926	1.00	20.00		C
  ATOM	1010	CG	ASN	G	197	27.362	3.819	20.456	1.00	20.00		C
  ATOM	1011	OD1	ASN	G	197	28.459	3.458	20.880	1.00	20.00		O
  ATOM	1012	ND2	ASN	G	197	27.228	4.768	19.541	1.00	20.00		N
  ATOM	1013	C	ASN	G	197	25.139	1.365	22.392	1.00	39.90		C
  ATOM	1014	O	ASN	G	197	25.185	1.357	23.621	1.00	39.04		O
  ATOM	1015	N	TYR	G	198	24.065	0.992	21.705	1.00	35.09		N
  ATOM	1016	CA	TYR	G	198	22.875	0.482	22.373	1.00	41.03		C
  ATOM	1017	CB	TYR	G	198	21.804	0.093	21.352	1.00	20.00		C
  ATOM	1018	CG	TYR	G	198	21.274	1.257	20.549	1.00	20.00		C
  ATOM	1019	CD1	TYR	G	198	20.238	2.041	21.031	1.00	20.00		C
  ATOM	1020	CE1	TYR	G	198	19.753	3.105	20.299	1.00	20.00		C
  ATOM	1021	CZ	TYR	G	198	20.310	3.398	19.069	1.00	20.00		C
  ATOM	1022	OH	TYR	G	198	19.829	4.450	18.325	1.00	20.00		O
  ATOM	1023	CE2	TYR	G	198	21.321	2.616	18.559	1.00	20.00		C
  ATOM	1024	CD2	TYR	G	198	21.799	1.557	19.299	1.00	20.00		C
  ATOM	1025	C	TYR	G	198	23.219	−0.712	23.252	1.00	43.65		C
  ATOM	1026	O	TYR	G	198	22.800	−0.783	24.406	1.00	52.37		O
  ATOM	1027	N	ILE	G	199	24.079	−1.587	22.744	1.00	35.86		N
  ATOM	1028	CA	ILE	G	199	24.490	−2.772	23.486	1.00	45.39		C
  ATOM	1029	CB	ILE	G	199	25.380	−3.704	22.627	1.00	20.00		C
  ATOM	1030	CG1	ILE	G	199	24.556	−4.357	21.512	1.00	20.00		C
  ATOM	1031	CD1	ILE	G	199	25.365	−5.260	20.598	1.00	20.00		C
  ATOM	1032	CG2	ILE	G	199	26.037	−4.775	23.487	1.00	20.00		C
  ATOM	1033	C	ILE	G	199	25.210	−2.392	24.779	1.00	37.89		C
  ATOM	1034	O	ILE	G	199	24.808	−2.808	25.865	1.00	45.28		O
  ATOM	1035	N	ASP	G	200	26.185	−1.495	24.669	1.00	37.36		N
  ATOM	1036	CA	ASP	G	200	26.988	−1.098	25.821	1.00	46.66		C
  ATOM	1037	CB	ASP	G	200	28.069	−0.096	25.405	1.00	20.00		C
  ATOM	1038	CG	ASP	G	200	29.216	−0.751	24.660	1.00	20.00		C
  ATOM	1039	OD1	ASP	G	200	29.360	−1.989	24.751	1.00	20.00		O
  ATOM	1040	OD2	ASP	G	200	29.996	−0.025	24.009	1.00	20.00		O
  ATOM	1041	C	ASP	G	200	26.109	−0.506	26.916	1.00	51.05		C
  ATOM	1042	O	ASP	G	200	26.370	−0.693	28.105	1.00	57.39		O
  ATOM	1043	N	LYS	G	201	25.004	0.108	26.507	1.00	57.68		N
  ATOM	1044	CA	LYS	G	201	24.104	0.766	27.443	1.00	44.02		C
  ATOM	1045	CB	LYS	G	201	23.138	1.687	26.698	1.00	20.00		C
  ATOM	1046	CG	LYS	G	201	23.815	2.816	25.941	1.00	20.00		C
  ATOM	1047	CD	LYS	G	201	22.797	3.680	25.223	1.00	20.00		C
  ATOM	1048	CE	LYS	G	201	23.464	4.802	24.446	1.00	20.00		C
  ATOM	1049	NZ	LYS	G	201	22.489	5.542	23.596	1.00	20.00		N
  ATOM	1050	C	LYS	G	201	23.325	−0.250	28.274	1.00	43.56		C
  ATOM	1051	O	LYS	G	201	22.868	0.060	29.374	1.00	51.34		O
  ATOM	1052	N	GLN	G	202	23.218	−1.475	27.764	1.00	46.06		N
  ATOM	1053	CA	GLN	G	202	22.308	−2.472	28.333	1.00	44.95		C
  ATOM	1054	CB	GLN	G	202	21.324	−2.975	27.277	1.00	20.00		C
  ATOM	1055	CG	GLN	G	202	20.207	−1.997	26.966	1.00	20.00		C
  ATOM	1056	CD	GLN	G	202	19.339	−2.450	25.809	1.00	20.00		C
  ATOM	1057	OE1	GLN	G	202	19.694	−3.372	25.074	1.00	20.00		O
  ATOM	1058	NE2	GLN	G	202	18.171	−1.835	25.672	1.00	20.00		N
  ATOM	1059	C	GLN	G	202	23.029	−3.657	28.974	1.00	42.35		C
  ATOM	1060	O	GLN	G	202	22.446	−4.374	29.787	1.00	47.00		O
  ATOM	1061	N	LEU	G	203	24.253	−3.922	28.530	1.00	49.55		N
  ATOM	1062	CA	LEU	G	203	25.003	−5.081	29.008	1.00	50.77		C
  ATOM	1063	CB	LEU	G	203	26.244	−5.322	28.140	1.00	20.00		C
  ATOM	1064	CG	LEU	G	203	26.031	−5.802	26.698	1.00	20.00		C
  ATOM	1065	CD1	LEU	G	203	27.361	−5.942	25.970	1.00	20.00		C
  ATOM	1066	CD2	LEU	G	203	25.263	−7.115	26.661	1.00	20.00		C
  ATOM	1067	C	LEU	G	203	25.397	−4.938	30.479	1.00	52.51		C
  ATOM	1068	O	LEU	G	203	25.830	−3.873	30.918	1.00	46.02		O
  ATOM	1069	N	LEU	G	204	25.226	−6.017	31.238	1.00	51.45		N
  ATOM	1070	CA	LEU	G	204	25.644	−6.053	32.635	1.00	58.44		C
  ATOM	1071	CB	LEU	G	204	24.863	−7.127	33.399	1.00	20.00		C
  ATOM	1072	CG	LEU	G	204	23.352	−6.918	33.522	1.00	20.00		C
  ATOM	1073	CD1	LEU	G	204	22.691	−8.136	34.147	1.00	20.00		C
  ATOM	1074	CD2	LEU	G	204	23.044	−5.665	34.328	1.00	20.00		C
  ATOM	1075	C	LEU	G	204	27.146	−6.307	32.759	1.00	54.99		C
  ATOM	1076	O	LEU	G	204	27.710	−7.096	31.998	1.00	55.13		O
  ATOM	1077	N	PRO	G	205	27.783	−5.693	33.770	1.00	58.64		N
  ATOM	1078	CA	PRO	G	205	29.236	−5.775	33.842	1.00	52.19		C
  ATOM	1079	CB	PRO	G	205	29.551	−5.040	35.142	1.00	20.00		C
  ATOM	1080	CG	PRO	G	205	28.379	−5.337	36.014	1.00	20.00		C
  ATOM	1081	CD	PRO	G	205	27.182	−5.464	35.099	1.00	20.00		C
  ATOM	1082	C	PRO	G	205	29.647	−7.230	33.970	1.00	54.30		C
  ATOM	1083	O	PRO	G	205	30.783	−7.593	33.663	1.00	70.22		O
  ATOM	1084	N	ILE	G	206	28.709	−8.050	34.430	1.00	62.70		N
  ATOM	1085	CA	ILE	G	206	28.925	−9.480	34.557	1.00	68.19		C
  ATOM	1086	CB	ILE	G	206	29.450	−9.843	35.957	1.00	20.00		C
  ATOM	1087	CG1	ILE	G	206	30.853	−9.269	36.164	1.00	20.00		C
  ATOM	1088	CD1	ILE	G	206	31.328	−9.317	37.600	1.00	20.00		C
  ATOM	1089	CG2	ILE	G	206	29.454	−11.352	36.151	1.00	20.00		C
  ATOM	1090	C	ILE	G	206	27.618	−10.223	34.304	1.00	62.35		C
  ATOM	1091	O	ILE	G	206	26.548	−9.772	34.715	1.00	67.16		O
  ATOM	1092	N	VAL	G	207	27.702	−11.314	33.552	1.00	52.22		N
  ATOM	1093	CA	VAL	G	207	26.527	−12.112	33.234	1.00	51.31		C
  ATOM	1094	CB	VAL	G	207	26.414	−12.378	31.722	1.00	20.00		C
  ATOM	1095	CG1	VAL	G	207	25.235	−13.293	31.430	1.00	20.00		C
  ATOM	1096	CG2	VAL	G	207	26.279	−11.066	30.963	1.00	20.00		C
  ATOM	1097	C	VAL	G	207	26.546	−13.438	33.985	1.00	62.09		C
  ATOM	1098	O	VAL	G	207	27.257	−14.369	33.605	1.00	58.88		O
  ATOM	1099	N	ASN	G	208	25.828	−13.484	35.102	1.00	71.72		N
  ATOM	1100	CA	ASN	G	208	25.723	−14.698	35.900	1.00	70.92		C
  ATOM	1101	CB	ASN	G	208	25.837	−14.370	37.390	1.00	20.00		C
  ATOM	1102	CG	ASN	G	208	27.235	−13.938	37.787	1.00	20.00		C
  ATOM	1103	OD1	ASN	G	208	28.216	−14.286	37.129	1.00	20.00		O
  ATOM	1104	ND2	ASN	G	208	27.335	−13.190	38.880	1.00	20.00		N
  ATOM	1105	C	ASN	G	208	24.423	−15.446	35.628	1.00	63.05		C
  ATOM	1106	O	ASN	G	208	23.637	−15.050	34.767	1.00	61.34		O
  ATOM	1107	N	LYS	G	209	24.168	−16.485	36.418	1.00	68.91		N
  ATOM	1108	CA	LYS	G	209	23.006	−17.341	36.212	1.00	59.11		C
  ATOM	1109	CB	LYS	G	209	23.129	−18.620	37.043	1.00	20.00		C
  ATOM	1110	CG	LYS	G	209	24.239	−19.552	36.588	1.00	20.00		C
  ATOM	1111	CD	LYS	G	209	24.335	−20.774	37.486	1.00	20.00		C
  ATOM	1112	CE	LYS	G	209	25.423	−21.724	37.012	1.00	20.00		C
  ATOM	1113	NZ	LYS	G	209	25.548	−22.912	37.901	1.00	20.00		N
  ATOM	1114	C	LYS	G	209	21.696	−16.628	36.539	1.00	50.69		C
  ATOM	1115	O	LYS	G	209	20.616	−17.121	36.212	1.00	51.01		O
  ATOM	1116	N	GLN	G	210	21.792	−15.499	37.235	1.00	44.68		N
  ATOM	1117	CA	GLN	G	210	20.621	−14.676	37.518	1.00	49.52		C
  ATOM	1118	CB	GLN	G	210	20.828	−13.874	38.806	1.00	20.00		C
  ATOM	1119	CG	GLN	G	210	20.877	−14.719	40.070	1.00	20.00		C
  ATOM	1120	CD	GLN	G	210	21.149	−13.893	41.313	1.00	20.00		C
  ATOM	1121	OE1	GLN	G	210	21.709	−12.800	41.237	1.00	20.00		O
  ATOM	1122	NE2	GLN	G	210	20.755	−14.417	42.469	1.00	20.00		N
  ATOM	1123	C	GLN	G	210	20.336	−13.730	36.356	1.00	62.08		C
  ATOM	1124	O	GLN	G	210	19.271	−13.785	35.741	1.00	80.43		O
  ATOM	1125	N	SER	G	211	21.324	−12.905	36.028	1.00	58.92		N
  ATOM	1126	CA	SER	G	211	21.231	−11.987	34.898	1.00	47.88		C
  ATOM	1127	CB	SER	G	211	22.594	−11.350	34.621	1.00	20.00		C
  ATOM	1128	OG	SER	G	211	23.553	−12.334	34.274	1.00	20.00		O
  ATOM	1129	C	SER	G	211	20.722	−12.689	33.642	1.00	57.32		C
  ATOM	1130	O	SER	G	211	19.919	−12.133	32.893	1.00	50.74		O
  ATOM	1131	N	CYS	G	212	21.149	−13.934	33.451	1.00	44.34		N
  ATOM	1132	CA	CYS	G	212	20.890	−14.659	32.210	1.00	57.52		C
  ATOM	1133	CB	CYS	G	212	21.127	−16.180	32.363	1.00	20.00		C
  ATOM	1134	SG	CYS	G	212	22.836	−16.682	32.889	1.00	20.00		S
  ATOM	1135	C	CYS	G	212	19.541	−14.314	31.540	1.00	60.91		C
  ATOM	1136	O	CYS	G	212	19.536	−13.729	30.460	1.00	52.17		O
  ATOM	1137	N	SER	G	213	18.465	−14.813	32.151	1.00	21.55		N
  ATOM	1138	CA	SER	G	213	17.107	−14.631	31.656	1.00	21.67		C
  ATOM	1139	CB	SER	G	213	16.133	−15.512	32.444	1.00	21.81		C
  ATOM	1140	OG	SER	G	213	16.471	−16.882	32.323	1.00	23.00		O
  ATOM	1141	C	SER	G	213	16.633	−13.188	31.682	1.00	21.45		C
  ATOM	1142	O	SER	G	213	16.026	−12.728	30.722	1.00	21.98		O
  ATOM	1143	N	ILE	G	214	16.856	−12.475	32.783	1.00	20.90		N
  ATOM	1144	CA	ILE	G	214	16.585	−11.050	32.758	1.00	20.45		C
  ATOM	1145	CB	ILE	G	214	16.587	−10.444	34.170	1.00	20.53		C
  ATOM	1146	CG1	ILE	G	214	15.498	−11.091	35.029	1.00	20.46		C
  ATOM	1147	CD1	ILE	G	214	15.418	−10.535	36.434	1.00	21.75		C
  ATOM	1148	CG2	ILE	G	214	16.393	−8.937	34.103	1.00	20.34		C
  ATOM	1149	C	ILE	G	214	17.686	−10.409	31.926	1.00	20.15		C
  ATOM	1150	O	ILE	G	214	17.435	−9.671	30.968	1.00	19.91		O
  ATOM	1151	N	SER	G	215	18.918	−10.770	32.280	1.00	19.84		N
  ATOM	1152	CA	SER	G	215	20.109	−10.297	31.594	1.00	19.58		C
  ATOM	1153	CB	SER	G	215	21.369	−10.722	32.349	1.00	19.76		C
  ATOM	1154	OG	SER	G	215	22.538	−10.269	31.688	1.00	19.97		O
  ATOM	1155	C	SER	G	215	20.132	−10.852	30.189	1.00	19.34		C
  ATOM	1156	O	SER	G	215	20.448	−10.152	29.230	1.00	19.54		O
  ATOM	1157	N	ASN	G	216	19.774	−12.125	30.082	1.00	18.80		N
  ATOM	1158	CA	ASN	G	216	19.738	−12.791	28.798	1.00	18.36		C
  ATOM	1159	CB	ASN	G	216	19.394	−14.271	28.966	1.00	18.41		C
  ATOM	1160	CG	ASN	G	216	20.426	−15.020	29.786	1.00	19.55		C
  ATOM	1161	OD1	ASN	G	216	20.308	−16.227	30.000	1.00	20.52		O
  ATOM	1162	ND2	ASN	G	216	21.445	−14.306	30.250	1.00	20.43		N
  ATOM	1163	C	ASN	G	216	18.708	−12.107	27.927	1.00	17.78		C
  ATOM	1164	O	ASN	G	216	18.930	−11.905	26.744	1.00	17.91		O
  ATOM	1165	N	ILE	G	217	17.578	−11.750	28.527	1.00	17.02		N
  ATOM	1166	CA	ILE	G	217	16.502	−11.089	27.804	1.00	16.60		C
  ATOM	1167	CB	ILE	G	217	15.247	−10.916	28.680	1.00	16.46		C
  ATOM	1168	CG1	ILE	G	217	14.608	−12.275	28.969	1.00	16.26		C
  ATOM	1169	CD1	ILE	G	217	13.360	−12.195	29.822	1.00	16.44		C
  ATOM	1170	CG2	ILE	G	217	14.251	−9.987	28.005	1.00	16.70		C
  ATOM	1171	C	ILE	G	217	16.953	−9.731	27.297	1.00	16.73		C
  ATOM	1172	O	ILE	G	217	16.658	−9.355	26.166	1.00	16.80		O
  ATOM	1173	N	GLU	G	218	17.679	−9.000	28.137	1.00	17.02		N
  ATOM	1174	CA	GLU	G	218	18.177	−7.692	27.741	1.00	17.70		C
  ATOM	1175	CB	GLU	G	218	18.867	−6.998	28.916	1.00	18.20		C
  ATOM	1176	CG	GLU	G	218	17.955	−6.748	30.106	1.00	21.31		C
  ATOM	1177	CD	GLU	G	218	18.652	−6.004	31.228	1.00	25.72		C
  ATOM	1178	OE1	GLU	G	218	18.016	−5.781	32.279	1.00	26.96		O
  ATOM	1179	OE2	GLU	G	218	19.834	−5.640	31.058	1.00	27.07		O
  ATOM	1180	C	GLU	G	218	19.144	−7.855	26.578	1.00	17.29		C
  ATOM	1181	O	GLU	G	218	19.123	−7.081	25.617	1.00	17.62		O
  ATOM	1182	N	THR	G	219	19.983	−8.882	26.667	1.00	16.62		N
  ATOM	1183	CA	THR	G	219	20.964	−9.150	25.630	1.00	15.95		C
  ATOM	1184	CB	THR	G	219	21.879	−10.328	26.007	1.00	15.95		C
  ATOM	1185	OG1	THR	G	219	22.582	−10.021	27.218	1.00	15.63		O
  ATOM	1186	CG2	THR	G	219	22.884	−10.597	24.897	1.00	15.97		C
  ATOM	1187	C	THR	G	219	20.250	−9.470	24.330	1.00	15.64		C
  ATOM	1188	O	THR	G	219	20.656	−9.022	23.267	1.00	15.93		O
  ATOM	1189	N	VAL	G	220	19.179	−10.248	24.431	1.00	14.98		N
  ATOM	1190	CA	VAL	G	220	18.390	−10.644	23.278	1.00	14.51		C
  ATOM	1191	CB	VAL	G	220	17.285	−11.644	23.665	1.00	14.29		C
  ATOM	1192	CG1	VAL	G	220	16.474	−12.037	22.440	1.00	14.24		C
  ATOM	1193	CG2	VAL	G	220	17.890	−12.871	24.329	1.00	14.10		C
  ATOM	1194	C	VAL	G	220	17.759	−9.424	22.636	1.00	14.64		C
  ATOM	1195	O	VAL	G	220	17.718	−9.315	21.420	1.00	14.79		O
  ATOM	1196	N	ILE	G	221	17.264	−8.510	23.463	1.00	14.43		N
  ATOM	1197	CA	ILE	G	221	16.658	−7.287	22.959	1.00	14.36		C
  ATOM	1198	CB	ILE	G	221	16.046	−6.448	24.095	1.00	14.03		C
  ATOM	1199	CG1	ILE	G	221	14.955	−7.243	24.816	1.00	13.72		C
  ATOM	1200	CD1	ILE	G	221	13.820	−7.679	23.914	1.00	14.17		C
  ATOM	1201	CG2	ILE	G	221	15.487	−5.142	23.550	1.00	13.91		C
  ATOM	1202	C	ILE	G	221	17.700	−6.459	22.222	1.00	14.82		C
  ATOM	1203	O	ILE	G	221	17.427	−5.902	21.158	1.00	14.82		O
  ATOM	1204	N	GLU	G	222	18.901	−6.390	22.788	1.00	15.51		N
  ATOM	1205	CA	GLU	G	222	19.983	−5.640	22.165	1.00	16.52		C
  ATOM	1206	CB	GLU	G	222	21.211	−5.601	23.076	1.00	16.80		C
  ATOM	1207	CG	GLU	G	222	20.971	−4.899	24.403	1.00	19.14		C
  ATOM	1208	CD	GLU	G	222	22.231	−4.780	25.236	1.00	22.62		C
  ATOM	1209	OE1	GLU	G	222	22.152	−4.246	26.362	1.00	24.35		O
  ATOM	1210	OE2	GLU	G	222	23.301	−5.219	24.765	1.00	23.98		O
  ATOM	1211	C	GLU	G	222	20.335	−6.269	20.825	1.00	16.65		C
  ATOM	1212	O	GLU	G	222	20.599	−5.574	19.842	1.00	16.95		O
  ATOM	1213	N	PHE	G	223	20.339	−7.597	20.802	1.00	16.70		N
  ATOM	1214	CA	PHE	G	223	20.652	−8.350	19.603	1.00	16.95		C
  ATOM	1215	CB	PHE	G	223	20.705	−9.848	19.904	1.00	16.85		C
  ATOM	1216	CG	PHE	G	223	21.104	−10.689	18.724	1.00	17.23		C
  ATOM	1217	CD1	PHE	G	223	22.438	−10.954	18.465	1.00	17.98		C
  ATOM	1218	CE1	PHE	G	223	22.808	−11.727	17.381	1.00	18.28		C
  ATOM	1219	CZ	PHE	G	223	21.842	−12.243	16.541	1.00	18.19		C
  ATOM	1220	CE2	PHE	G	223	20.508	−11.986	16.788	1.00	18.14		C
  ATOM	1221	CD2	PHE	G	223	20.144	−11.213	17.874	1.00	17.75		C
  ATOM	1222	C	PHE	G	223	19.610	−8.066	18.540	1.00	17.28		C
  ATOM	1223	O	PHE	G	223	19.945	−7.907	17.382	1.00	17.17		O
  ATOM	1224	N	GLN	G	224	18.348	−8.003	18.948	1.00	17.62		N
  ATOM	1225	CA	GLN	G	224	17.243	−7.712	18.044	1.00	18.16		C
  ATOM	1226	CB	GLN	G	224	15.898	−7.868	18.757	1.00	18.51		C
  ATOM	1227	CG	GLN	G	224	15.586	−9.296	19.178	1.00	20.06		C
  ATOM	1228	CD	GLN	G	224	14.158	−9.465	19.658	1.00	22.03		C
  ATOM	1229	OE1	GLN	G	224	13.769	−10.539	20.117	1.00	22.15		O
  ATOM	1230	NE2	GLN	G	224	13.368	−8.403	19.552	1.00	22.11		N
  ATOM	1231	C	GLN	G	224	17.387	−6.309	17.475	1.00	18.04		C
  ATOM	1232	O	GLN	G	224	17.090	−6.068	16.306	1.00	18.17		O
  ATOM	1233	N	GLN	G	225	17.819	−5.382	18.323	1.00	17.90		N
  ATOM	1234	CA	GLN	G	225	18.051	−4.012	17.894	1.00	17.95		C
  ATOM	1235	CB	GLN	G	225	18.389	−3.120	19.090	1.00	18.13		C
  ATOM	1236	CG	GLN	G	225	17.267	−3.006	20.109	1.00	19.04		C
  ATOM	1237	CD	GLN	G	225	17.588	−2.034	21.227	1.00	21.22		C
  ATOM	1238	OE1	GLN	G	225	18.661	−1.431	21.252	1.00	22.55		O
  ATOM	1239	NE2	GLN	G	225	16.656	−1.876	22.159	1.00	22.48		N
  ATOM	1240	C	GLN	G	225	19.168	−3.958	16.855	1.00	17.84		C
  ATOM	1241	O	GLN	G	225	19.061	−3.239	15.861	1.00	17.71		O
  ATOM	1242	N	LYS	G	226	20.235	−4.724	17.077	1.00	17.95		N
  ATOM	1243	CA	LYS	G	226	21.328	−4.762	16.112	1.00	18.00		C
  ATOM	1244	CB	LYS	G	226	22.486	−5.613	16.634	1.00	18.21		C
  ATOM	1245	CG	LYS	G	226	23.157	−5.048	17.875	1.00	18.50		C
  ATOM	1246	CD	LYS	G	226	24.365	−5.878	18.279	1.00	19.87		C
  ATOM	1247	CE	LYS	G		226	25.066	−5.278	19.487	1.00	21.36		C
  ATOM	1248	NZ	LYS	G	226	26.270	−6.061	19.878	1.00	21.83		N
  ATOM	1249	C	LYS	G	226	20.772	−5.345	14.826	1.00	17.84		C
  ATOM	1250	O	LYS	G	226	21.062	−4.880	13.723	1.00	17.94		O
  ATOM	1251	N	ASN	G	227	19.954	−6.374	15.002	1.00	17.70		N
  ATOM	1252	CA	ASN	G	227	19.238	−7.032	13.932	1.00	17.66		C
  ATOM	1253	CB	ASN	G	227	18.471	−8.244	14.459	1.00	17.36		C
  ATOM	1254	CG	ASN	G	227	19.384	−9.296	15.057	1.00	17.40		C
  ATOM	1255	OD1	ASN	G	227	18.929	−10.350	15.502	1.00	17.84		O
  ATOM	1256	ND2	ASN	G	227	20.682	−9.015	15.070	1.00	17.22		N
  ATOM	1257	C	ASN	G	227	18.287	−6.028	13.328	1.00	17.76		C
  ATOM	1258	O	ASN	G	227	18.159	−5.956	12.106	1.00	17.92		O
  ATOM	1259	N	ASN	G	228	17.627	−5.226	14.164	1.00	17.78		N
  ATOM	1260	CA	ASN	G	228	16.800	−4.172	13.548	1.00	17.59		C
  ATOM	1261	CB	ASN	G	228	15.958	−3.344	14.528	1.00	17.89		C
  ATOM	1262	CG	ASN	G	228	15.101	−2.277	13.809	1.00	18.43		C
  ATOM	1263	OD1	ASN	G	228	15.506	−1.119	13.688	1.00	18.74		O
  ATOM	1264	ND2	ASN	G	228	13.998	−2.715	13.205	1.00	18.61		N
  ATOM	1265	C	ASN	G	228	17.603	−3.255	12.662	1.00	17.09		C
  ATOM	1266	O	ASN	G	228	17.657	−3.466	11.456	1.00	17.17		O
  ATOM	1267	N	ARG	G	229	18.197	−2.211	13.224	1.00	16.33		N
  ATOM	1268	CA	ARG	G	229	19.046	−1.400	12.381	1.00	15.76		C
  ATOM	1269	CB	ARG	G	229	19.957	−0.486	13.184	1.00	15.70		C
  ATOM	1270	CG	ARG	G	229	20.207	0.822	12.468	1.00	14.99		C
  ATOM	1271	CD	ARG	G	229	21.391	1.555	13.041	1.00	15.33		C
  ATOM	1272	NE	ARG	G	229	22.116	2.303	12.021	1.00	15.59		N
  ATOM	1273	CZ	ARG	G	229	23.182	3.053	12.276	1.00	15.85		C
  ATOM	1274	NH1	ARG	G	229	23.593	3.214	13.525	1.00	16.20		N
  ATOM	1275	NH2	ARG	G	229	23.859	3.614	11.285	1.00	16.63		N
  ATOM	1276	C	ARG	G	229	19.863	−2.343	11.516	1.00	15.62		C
  ATOM	1277	O	ARG	G	229	19.671	−2.402	10.304	1.00	15.73		O
  ATOM	1278	N	LEU	G	230	20.612	−3.225	12.168	1.00	15.46		N
  ATOM	1279	CA	LEU	G	230	21.409	−4.212	11.454	1.00	15.22		C
  ATOM	1280	CB	LEU	G	230	22.161	−5.113	12.432	1.00	15.08		C
  ATOM	1281	CG	LEU	G	230	23.055	−6.187	11.808	1.00	14.70		C
  ATOM	1282	CD1	LEU	G	230	24.375	−5.579	11.364	1.00	15.19		C
  ATOM	1283	CD2	LEU	G	230	23.300	−7.324	12.791	1.00	15.46		C
  ATOM	1284	C	LEU	G	230	20.565	−5.055	10.501	1.00	15.31		C
  ATOM	1285	O	LEU	G	230	20.963	−5.294	9.362	1.00	15.46		O
  ATOM	1286	N	LEU	G	231	19.444	−5.573	10.997	1.00	15.48		N
  ATOM	1287	CA	LEU	G	231	18.581	−6.442	10.197	1.00	15.75		C
  ATOM	1288	CB	LEU	G	231	17.308	−6.793	10.967	1.00	15.90		C
  ATOM	1289	CG	LEU	G	231	17.482	−7.640	12.226	1.00	16.63		C
  ATOM	1290	CD1	LEU	G	231	16.128	−8.049	12.772	1.00	18.45		C
  ATOM	1291	CD2	LEU	G	231	18.348	−8.858	11.954	1.00	16.67		C
  ATOM	1292	C	LEU	G	231	18.210	−5.785	8.872	1.00	15.76		C
  ATOM	1293	O	LEU	G	231	18.203	−6.432	7.824	1.00	15.84		O
  ATOM	1294	N	GLU	G	232	17.824	−4.516	8.943	1.00	15.71		N
  ATOM	1295	CA	GLU	G	232	17.298	−3.811	7.786	1.00	15.93		C
  ATOM	1296	CB	GLU	G	232	16.537	−2.565	8.229	1.00	16.15		C
  ATOM	1297	CG	GLU	G	232	15.461	−2.846	9.254	1.00	18.59		C
  ATOM	1298	CD	GLU	G	232	14.077	−2.874	8.644	1.00	21.47		C
  ATOM	1299	OE1	GLU	G	232	13.964	−3.077	7.415	1.00	22.14		O
  ATOM	1300	OE2	GLU	G	232	13.100	−2.664	9.393	1.00	23.34		O
  ATOM	1301	C	GLU	G	232	18.399	−3.431	6.806	1.00	15.45		C
  ATOM	1302	O	GLU	G	232	18.169	−3.373	5.601	1.00	15.95		O
  ATOM	1303	N	ILE	G	233	19.594	−3.169	7.323	1.00	14.54		N
  ATOM	1304	CA	ILE	G	233	20.774	−3.128	6.476	1.00	13.69		C
  ATOM	1305	CB	ILE	G	233	22.049	−2.830	7.281	1.00	13.63		C
  ATOM	1306	CG1	ILE	G	233	21.823	−1.640	8.211	1.00	13.58		C
  ATOM	1307	CD1	ILE	G	233	23.101	−0.917	8.578	1.00	13.55		C
  ATOM	1308	CG2	ILE	G	233	23.215	−2.543	6.348	1.00	13.88		C
  ATOM	1309	C	ILE	G	233	20.927	−4.450	5.736	1.00	13.28		C
  ATOM	1310	O	ILE	G	233	20.979	−4.473	4.508	1.00	13.04		O
  ATOM	1311	N	THR	G	234	20.758	−5.546	6.469	1.00	13.18		N
  ATOM	1312	CA	THR	G	234	21.038	−6.878	5.940	1.00	13.39		C
  ATOM	1313	CB	THR	G	234	20.839	−7.965	7.015	1.00	13.21		C
  ATOM	1314	OG1	THR	G	234	21.845	−7.836	8.028	1.00	13.15		O
  ATOM	1315	CG2	THR	G	234	20.916	−9.351	6.394	1.00	13.22		C
  ATOM	1316	C	THR	G	234	20.146	−7.204	4.748	1.00	13.76		C
  ATOM	1317	O	THR	G	234	20.606	−7.766	3.753	1.00	13.95		O
  ATOM	1318	N	ARG	G	235	18.849	−6.966	4.911	1.00	14.26		N
  ATOM	1319	CA	ARG	G	235	17.891	−7.151	3.826	1.00	14.92		C
  ATOM	1320	CB	ARG	G	235	16.463	−6.925	4.328	1.00	15.30		C
  ATOM	1321	CG	ARG	G	235	15.771	−5.712	3.722	1.00	16.27		C
  ATOM	1322	CD	ARG	G	235	14.867	−5.020	4.735	1.00	18.52		C
  ATOM	1323	NE	ARG	G	235	14.345	−5.948	5.734	1.00	17.86		N
  ATOM	1324	CZ	ARG	G	235	13.438	−6.884	5.478	1.00	16.91		C
  ATOM	1325	NH1	ARG	G	235	12.970	−7.035	4.248	1.00	16.59		N
  ATOM	1326	NH2	ARG	G	235	13.018	−7.687	6.444	1.00	16.86		N
  ATOM	1327	C	ARG	G	235	18.192	−6.211	2.665	1.00	15.05		C
  ATOM	1328	O	ARG	G	235	18.292	−6.640	1.517	1.00	15.15		O
  ATOM	1329	N	GLU	G	236	18.386	−4.935	2.984	1.00	15.18		N
  ATOM	1330	CA	GLU	G	236	18.751	−3.930	1.992	1.00	15.24		C
  ATOM	1331	CB	GLU	G	236	19.179	−2.636	2.687	1.00	15.69		C
  ATOM	1332	CG	GLU	G	236	18.875	−1.369	1.904	1.00	18.22		C
  ATOM	1333	CD	GLU	G	236	19.004	−0.115	2.750	1.00	21.59		C
  ATOM	1334	OE1	GLU	G	236	19.395	0.937	2.199	1.00	24.41		O
  ATOM	1335	OE2	GLU	G	236	18.660	−0.168	3.953	1.00	21.59		O
  ATOM	1336	C	GLU	G	236	19.870	−4.421	1.077	1.00	14.61		C
  ATOM	1337	O	GLU	G	236	19.746	−4.377	−0.147	1.00	14.82		O
  ATOM	1338	N	PHE	G	237	20.963	−4.883	1.675	1.00	14.05		N
  ATOM	1339	CA	PHE	G	237	22.110	−5.358	0.907	1.00	13.84		C
  ATOM	1340	CB	PHE	G	237	23.285	−5.682	1.836	1.00	14.04		C
  ATOM	1341	CG	PHE	G	237	24.161	−4.500	2.143	1.00	14.84		C
  ATOM	1342	CD1	PHE	G	237	24.412	−4.131	3.454	1.00	15.30		C
  ATOM	1343	CE1	PHE	G	237	25.268	−3.087	3.743	1.00	15.15		C
  ATOM	1344	CZ	PHE	G	237	25.871	−2.389	2.717	1.00	15.19		C
  ATOM	1345	CE2	PHE	G	237	25.645	−2.760	1.407	1.00	15.02		C
  ATOM	1346	CD2	PHE	G	237	24.796	−3.809	1.125	1.00	15.03		C
  ATOM	1347	C	PHE	G	237	21.741	−6.586	0.078	1.00	13.51		C
  ATOM	1348	O	PHE	G	237	22.027	−6.652	−1.117	1.00	13.43		O
  ATOM	1349	N	SER	G	238	21.092	−7.551	0.721	1.00	13.11		N
  ATOM	1350	CA	SER	G	238	20.669	−8.772	0.049	1.00	12.82		C
  ATOM	1351	CB	SER	G	238	19.929	−9.688	1.021	1.00	12.86		C
  ATOM	1352	OG	SER	G	238	20.730	−9.975	2.151	1.00	12.76		O
  ATOM	1353	C	SER	G	238	19.770	−8.444	−1.131	1.00	12.69		C
  ATOM	1354	O	SER	G	238	19.749	−9.165	−2.128	1.00	12.63		O
  ATOM	1355	N	VAL	G	239	19.024	−7.352	−1.010	1.00	12.59		N
  ATOM	1356	CA	VAL	G	239	18.143	−6.916	−2.082	1.00	12.80		C
  ATOM	1357	CB	VAL	G	239	17.045	−5.961	−1.578	1.00	12.71		C
  ATOM	1358	CG1	VAL	G	239	16.215	−5.451	−2.747	1.00	13.63		C
  ATOM	1359	CG2	VAL	G	239	16.157	−6.658	−0.562	1.00	13.57		C
  ATOM	1360	C	VAL	G	239	18.906	−6.242	−3.214	1.00	12.94		C
  ATOM	1361	O	VAL	G	239	18.337	−5.980	−4.273	1.00	13.10		O
  ATOM	1362	N	ASN	G	240	20.173	−5.913	−2.981	1.00	4.15		N
  ATOM	1363	CA	ASN	G	240	20.892	−5.047	−3.909	1.00	4.33		C
  ATOM	1364	CB	ASN	G	240	21.377	−3.779	−3.214	1.00	4.59		C
  ATOM	1365	CG	ASN	G	240	20.260	−2.790	−2.978	1.00	5.36		C
  ATOM	1366	OD1	ASN	G	240	19.681	−2.263	−3.926	1.00	6.27		O
  ATOM	1367	ND2	ASN	G	240	19.828	−2.683	−1.727	1.00	7.15		N
  ATOM	1368	C	ASN	G	240	22.025	−5.707	−4.689	1.00	4.19		C
  ATOM	1369	O	ASN	G	240	22.565	−5.115	−5.625	1.00	4.19		O
  ATOM	1370	N	ALA	G	241	22.299	−6.970	−4.382	1.00	3.93		N
  ATOM	1371	CA	ALA	G	241	23.459	−7.657	−4.941	1.00	3.90		C
  ATOM	1372	CB	ALA	G	241	23.179	−8.102	−6.368	1.00	3.86		C
  ATOM	1373	C	ALA	G	241	24.702	−6.772	−4.887	1.00	4.22		C
  ATOM	1374	O	ALA	G	241	25.347	−6.532	−5.907	1.00	4.47		O
  ATOM	1375	N	GLY	G	242	24.955	−6.190	−3.719	1.00	4.53		N
  ATOM	1376	CA	GLY	G	242	26.289	−5.717	−3.368	1.00	4.65		C
  ATOM	1377	C	GLY	G	242	26.609	−4.323	−3.872	1.00	4.67		C
  ATOM	1378	O	GLY	G	242	27.770	−3.913	−3.869	1.00	5.27		O
  ATOM	1379	N	VAL	G	243	25.577	−3.570	−4.246	1.00	4.37		N
  ATOM	1380	CA	VAL	G	243	25.750	−2.172	−4.646	1.00	4.32		C
  ATOM	1381	CB	VAL	G	243	26.048	−2.039	−6.153	1.00	3.99		C
  ATOM	1382	CG1	VAL	G	243	26.962	−0.845	−6.414	1.00	4.22		C
  ATOM	1383	CG2	VAL	G	243	26.649	−3.327	−6.699	1.00	3.85		C
  ATOM	1384	C	VAL	G	243	24.510	−1.342	−4.335	1.00	4.61		C
  ATOM	1385	O	VAL	G	243	23.394	−1.734	−4.673	1.00	4.89		O
  ATOM	1386	N	THR	G	244	24.722	−0.145	−3.801	1.00	4.95		N
  ATOM	1387	CA	THR	G	244	23.615	0.714	−3.408	1.00	5.71		C
  ATOM	1388	CB	THR	G	244	23.475	0.801	−1.879	1.00	6.11		C
  ATOM	1389	OG1	THR	G	244	24.257	−0.228	−1.260	1.00	7.17		O
  ATOM	1390	CG2	THR	G	244	22.028	0.651	−1.475	1.00	7.55		C
  ATOM	1391	C	THR	G	244	23.802	2.114	−3.967	1.00	5.61		C
  ATOM	1392	O	THR	G	244	24.927	2.590	−4.117	1.00	5.85		O
  ATOM	1393	N	THR	G	245	22.695	2.794	−4.223	1.00	5.53		N
  ATOM	1394	CA	THR	G	245	22.677	4.241	−4.120	1.00	5.81		C
  ATOM	1395	CB	THR	G	245	22.461	4.903	−5.490	1.00	6.13		C
  ATOM	1396	OG1	THR	G	245	23.555	4.575	−6.355	1.00	8.11		O
  ATOM	1397	CG2	THR	G	245	22.394	6.408	−5.336	1.00	6.63		C
  ATOM	1398	C	THR	G	245	21.609	4.679	−3.126	1.00	5.73		C
  ATOM	1399	O	THR	G	245	20.778	3.869	−2.718	1.00	5.86		O
  ATOM	1400	N	PRO	G	246	21.521	5.993	−2.867	1.00	5.68		N
  ATOM	1401	CA	PRO	G	246	21.893	6.537	−1.574	1.00	5.11		C
  ATOM	1402	CB	PRO	G	246	20.537	6.719	−0.893	1.00	5.19		C
  ATOM	1403	CG	PRO	G	246	19.582	7.023	−2.060	1.00	5.90		C
  ATOM	1404	CD	PRO	G	246	20.305	6.660	−3.353	1.00	6.36		C
  ATOM	1405	C	PRO	G	246	22.831	5.666	−0.743	1.00	4.85		C
  ATOM	1406	O	PRO	G	246	22.663	4.447	−0.677	1.00	5.25		O
  ATOM	1407	N	VAL	G	247	23.900	6.281	−0.249	1.00	4.35		N
  ATOM	1408	CA	VAL	G	247	24.742	5.647	0.749	1.00	3.82		C
  ATOM	1409	CB	VAL	G	247	26.177	6.196	0.717	1.00	3.52		C
  ATOM	1410	CG1	VAL	G	247	27.082	5.352	1.597	1.00	3.62		C
  ATOM	1411	CG2	VAL	G	247	26.697	6.207	−0.707	1.00	3.60		C
  ATOM	1412	C	VAL	G	247	24.134	5.824	2.131	1.00	3.69		C
  ATOM	1413	O	VAL	G	247	24.038	6.942	2.637	1.00	3.36		O
  ATOM	1414	N	SER	G	248	23.471	4.769	2.588	1.00	3.72		N
  ATOM	1415	CA	SER	G	248	22.676	4.824	3.803	1.00	3.96		C
  ATOM	1416	CB	SER	G	248	22.187	3.427	4.172	1.00	4.07		C
  ATOM	1417	OG	SER	G	248	23.188	2.722	4.884	1.00	4.13		O
  ATOM	1418	C	SER	G	248	23.484	5.392	4.959	1.00	4.35		C
  ATOM	1419	O	SER	G	248	24.697	5.201	5.026	1.00	4.36		O
  ATOM	1420	N	THR	G	249	22.776	5.880	5.972	1.00	4.53		N
  ATOM	1421	CA	THR	G	249	23.405	6.259	7.226	1.00	4.61		C
  ATOM	1422	CB	THR	G	249	22.408	6.945	8.175	1.00	4.70		C
  ATOM	1423	OG1	THR	G	249	21.562	5.959	8.778	1.00	5.42		O
  ATOM	1424	CG2	THR	G	249	21.553	7.945	7.412	1.00	4.88		C
  ATOM	1425	C	THR	G	249	24.026	5.054	7.925	1.00	4.47		C
  ATOM	1426	O	THR	G	249	24.830	5.210	8.844	1.00	4.74		O
  ATOM	1427	N	TYR	G	250	23.694	3.855	7.454	1.00	4.32		N
  ATOM	1428	CA	TYR	G	250	24.325	2.641	7.968	1.00	4.42		C
  ATOM	1429	CB	TYR	G	250	23.393	1.435	7.845	1.00	4.91		C
  ATOM	1430	CG	TYR	G	250	22.028	1.638	8.462	1.00	6.81		C
  ATOM	1431	CD1	TYR	G	250	20.881	1.242	7.790	1.00	8.89		C
  ATOM	1432	CE1	TYR	G	250	19.631	1.390	8.359	1.00	10.73		C
  ATOM	1433	CZ	TYR	G	250	19.513	1.941	9.622	1.00	12.28		C
  ATOM	1434	OH	TYR	G	250	18.265	2.135	10.172	1.00	12.24		O
  ATOM	1435	CE2	TYR	G	250	20.640	2.325	10.320	1.00	12.15		C
  ATOM	1436	CD2	TYR	G	250	21.890	2.148	9.749	1.00	9.81		C
  ATOM	1437	C	TYR	G	250	25.656	2.342	7.285	1.00	4.21		C
  ATOM	1438	O	TYR	G	250	26.539	1.730	7.886	1.00	4.20		O
  ATOM	1439	N	MET	G	251	25.766	2.697	6.007	1.00	4.14		N
  ATOM	1440	CA	MET	G	251	27.045	2.616	5.300	1.00	4.15		C
  ATOM	1441	CB	MET	G	251	26.852	2.798	3.790	1.00	4.14		C
  ATOM	1442	CG	MET	G	251	26.019	1.722	3.123	1.00	4.51		C
  ATOM	1443	SD	MET	G	251	26.772	0.087	3.219	1.00	3.81		S
  ATOM	1444	CE	MET	G	251	25.773	−0.814	2.036	1.00	4.55		C
  ATOM	1445	C	MET	G	251	27.996	3.686	5.816	1.00	4.13		C
  ATOM	1446	O	MET	G	251	29.178	3.427	6.043	1.00	4.24		O
  ATOM	1447	N	LEU	G	252	27.495	4.913	5.886	1.00	4.23		N
  ATOM	1448	CA	LEU	G	252	28.283	6.032	6.369	1.00	4.22		C
  ATOM	1449	CB	LEU	G	252	28.645	6.965	5.215	1.00	4.14		C
  ATOM	1450	CG	LEU	G	252	30.017	6.731	4.581	1.00	4.05		C
  ATOM	1451	CD1	LEU	G	252	30.513	7.997	3.891	1.00	5.22		C
  ATOM	1452	CD2	LEU	G	252	31.023	6.242	5.617	1.00	6.20		C
  ATOM	1453	C	LEU	G	252	27.515	6.799	7.432	1.00	4.62		C
  ATOM	1454	O	LEU	G	252	26.389	7.238	7.203	1.00	4.97		O
  ATOM	1455	N	THR	G	253	28.127	6.949	8.600	1.00	4.90		N
  ATOM	1456	CA	THR	G	253	27.659	7.913	9.583	1.00	5.57		C
  ATOM	1457	CB	THR	G	253	28.420	7.769	10.903	1.00	5.55		C
  ATOM	1458	OG1	THR	G	253	28.440	6.390	11.293	1.00	6.43		O
  ATOM	1459	CG2	THR	G	253	27.757	8.598	11.988	1.00	6.28		C
  ATOM	1460	C	THR	G	253	27.865	9.329	9.069	1.00	6.03		C
  ATOM	1461	O	THR	G	253	28.888	9.629	8.453	1.00	6.68		O
  ATOM	1462	N	ASN	G	254	26.974	10.230	9.460	1.00	6.39		N
  ATOM	1463	CA	ASN	G	254	27.257	11.649	9.342	1.00	6.79		C
  ATOM	1464	CB	ASN	G	254	26.292	12.459	10.198	1.00	6.85		C
  ATOM	1465	CG	ASN	G	254	26.317	13.927	9.853	1.00	6.81		C
  ATOM	1466	OD1	ASN	G	254	25.991	14.303	8.728	1.00	7.67		O
  ATOM	1467	ND2	ASN	G	254	26.919	14.726	10.726	1.00	6.19		N
  ATOM	1468	C	ASN	G	254	28.685	11.958	9.760	1.00	7.08		C
  ATOM	1469	O	ASN	G	254	29.495	12.426	8.961	1.00	6.90		O
  ATOM	1470	N	SER	G	255	28.974	11.718	11.034	1.00	7.21		N
  ATOM	1471	CA	SER	G	255	30.320	11.869	11.561	1.00	7.37		C
  ATOM	1472	CB	SER	G	255	30.477	11.067	12.859	1.00	8.09		C
  ATOM	1473	OG	SER	G	255	29.239	10.928	13.536	1.00	10.47		O
  ATOM	1474	C	SER	G	255	31.365	11.429	10.538	1.00	6.82		C
  ATOM	1475	O	SER	G	255	32.237	12.207	10.150	1.00	6.99		O
  ATOM	1476	N	GLU	G	256	31.240	10.192	10.068	1.00	6.17		N
  ATOM	1477	CA	GLU	G	256	32.218	9.629	9.152	1.00	6.13		C
  ATOM	1478	CB	GLU	G	256	31.913	8.158	8.883	1.00	6.22		C
  ATOM	1479	CG	GLU	G	256	32.296	7.240	10.026	1.00	8.41		C
  ATOM	1480	CD	GLU	G	256	31.422	6.006	10.099	1.00	10.26		C
  ATOM	1481	OE1	GLU	G	256	30.637	5.776	9.156	1.00	11.90		O
  ATOM	1482	OE2	GLU	G	256	31.532	5.255	11.090	1.00	9.55		O
  ATOM	1483	C	GLU	G	256	32.231	10.401	7.845	1.00	5.76		C
  ATOM	1484	O	GLU	G	256	33.275	10.892	7.418	1.00	5.93		O
  ATOM	1485	N	LEU	G	257	31.075	10.476	7.194	1.00	5.67		N
  ATOM	1486	CA	LEU	G	257	30.972	11.191	5.930	1.00	5.37		C
  ATOM	1487	CB	LEU	G	257	29.512	11.334	5.486	1.00	5.03		C
  ATOM	1488	CG	LEU	G	257	29.282	12.309	4.325	1.00	3.65		C
  ATOM	1489	CD1	LEU	G	257	29.846	11.755	3.024	1.00	2.00		C
  ATOM	1490	CD2	LEU	G	257	27.810	12.657	4.172	1.00	2.14		C
  ATOM	1491	C	LEU	G	257	31.623	12.563	6.048	1.00	5.64		C
  ATOM	1492	O	LEU	G	257	32.401	12.970	5.185	1.00	5.81		O
  ATOM	1493	N	LEU	G	258	31.353	13.249	7.153	1.00	5.75		N
  ATOM	1494	CA	LEU	G	258	31.792	14.629	7.301	1.00	5.91		C
  ATOM	1495	CB	LEU	G	258	31.162	15.276	8.535	1.00	6.10		C
  ATOM	1496	CG	LEU	G	258	29.897	16.091	8.256	1.00	5.75		C
  ATOM	1497	CD1	LEU	G	258	29.230	16.525	9.552	1.00	6.33		C
  ATOM	1498	CD2	LEU	G	258	30.219	17.294	7.385	1.00	7.33		C
  ATOM	1499	C	LEU	G	258	33.315	14.758	7.331	1.00	6.03		C
  ATOM	1500	O	LEU	G	258	33.874	15.664	6.713	1.00	5.73		O
  ATOM	1501	N	SER	G	259	33.983	13.867	8.061	1.00	6.47		N
  ATOM	1502	CA	SER	G	259	35.442	13.887	8.139	1.00	6.95		C
  ATOM	1503	CB	SER	G	259	35.929	13.137	9.381	1.00	7.05		C
  ATOM	1504	OG	SER	G	259	36.284	11.802	9.064	1.00	6.86		O
  ATOM	1505	C	SER	G	259	36.060	13.284	6.883	1.00	6.74		C
  ATOM	1506	O	SER	G	259	37.173	13.638	6.493	1.00	6.86		O
  ATOM	1507	N	LEU	G	260	35.311	12.400	6.234	1.00	6.31		N
  ATOM	1508	CA	LEU	G	260	35.715	11.854	4.946	1.00	6.09		C
  ATOM	1509	CB	LEU	G	260	34.747	10.756	4.507	1.00	6.09		C
  ATOM	1510	CG	LEU	G	260	35.306	9.334	4.473	1.00	6.24		C
  ATOM	1511	CD1	LEU	G	260	34.338	8.388	3.779	1.00	6.53		C
  ATOM	1512	CD2	LEU	G	260	36.663	9.309	3.790	1.00	5.98		C
  ATOM	1513	C	LEU	G	260	35.775	12.947	3.887	1.00	6.25		C
  ATOM	1514	O	LEU	G	260	36.696	12.982	3.072	1.00	6.37		O
  ATOM	1515	N	ILE	G	261	34.724	13.760	3.826	1.00	6.63		N
  ATOM	1516	CA	ILE	G	261	34.729	14.952	2.987	1.00	7.19		C
  ATOM	1517	CB	ILE	G	261	33.504	15.840	3.262	1.00	7.09		C
  ATOM	1518	CG1	ILE	G	261	32.292	15.350	2.474	1.00	7.46		C
  ATOM	1519	CD1	ILE	G	261	30.991	15.952	2.951	1.00	8.38		C
  ATOM	1520	CG2	ILE	G	261	33.809	17.290	2.916	1.00	6.61		C
  ATOM	1521	C	ILE	G	261	35.966	15.768	3.307	1.00	8.01		C
  ATOM	1522	O	ILE	G	261	36.716	16.162	2.414	1.00	8.26		O
  ATOM	1523	N	ASN	G	262	36.157	16.040	4.592	1.00	9.05		N
  ATOM	1524	CA	ASN	G	262	37.337	16.748	5.049	1.00	9.88		C
  ATOM	1525	CB	ASN	G	262	37.517	16.575	6.555	1.00	9.99		C
  ATOM	1526	CG	ASN	G	262	38.185	17.770	7.197	1.00	11.16		C
  ATOM	1527	OD1	ASN	G	262	38.493	18.756	6.526	1.00	12.70		O
  ATOM	1528	ND2	ASN	G	262	38.391	17.701	8.506	1.00	13.20		N
  ATOM	1529	C	ASN	G	262	38.585	16.282	4.316	1.00	10.17		C
  ATOM	1530	O	ASN	G	262	39.426	17.093	3.928	1.00	10.52		O
  ATOM	1531	N	ASP	G	263	38.684	14.976	4.094	1.00	10.62		N
  ATOM	1532	CA	ASP	G	263	39.925	14.380	3.621	1.00	11.02		C
  ATOM	1533	CB	ASP	G	263	40.022	12.917	4.055	1.00	11.49		C
  ATOM	1534	CG	ASP	G	263	41.297	12.251	3.577	1.00	12.80		C
  ATOM	1535	OD1	ASP	G	263	42.377	12.863	3.715	1.00	14.72		O
  ATOM	1536	OD2	ASP	G	263	41.220	11.113	3.068	1.00	13.88		O
  ATOM	1537	C	ASP	G	263	40.067	14.491	2.107	1.00	10.92		C
  ATOM	1538	O	ASP	G	263	41.135	14.224	1.556	1.00	10.96		O
  ATOM	1539	N	MET	G	264	39.003	14.931	1.442	1.00	10.91		N
  ATOM	1540	CA	MET	G	264	38.989	14.992	−0.015	1.00	10.78		C
  ATOM	1541	CB	MET	G	264	37.557	15.121	−0.534	1.00	10.51		C
  ATOM	1542	CG	MET	G	264	36.669	13.937	−0.194	1.00	11.26		C
  ATOM	1543	SD	MET	G	264	35.025	14.078	−0.916	1.00	12.70		S
  ATOM	1544	CE	MET	G	264	34.634	15.778	−0.513	1.00	13.92		C
  ATOM	1545	C	MET	G	264	39.851	16.135	−0.543	1.00	10.85		C
  ATOM	1546	O	MET	G	264	39.830	17.238	0.002	1.00	11.03		O
  ATOM	1547	N	PRO	G	265	40.626	15.863	−1.604	1.00	10.88		N
  ATOM	1548	CA	PRO	G	265	41.558	16.827	−2.184	1.00	11.09		C
  ATOM	1549	CB	PRO	G	265	42.357	15.986	−3.188	1.00	11.28		C
  ATOM	1550	CG	PRO	G	265	41.513	14.787	−3.453	1.00	11.24		C
  ATOM	1551	CD	PRO	G	265	40.807	14.515	−2.167	1.00	11.03		C
  ATOM	1552	C	PRO	G	265	40.845	17.965	−2.908	1.00	11.19		C
  ATOM	1553	O	PRO	G	265	41.070	18.175	−4.100	1.00	11.47		O
  ATOM	1554	N	ILE	G	266	40.053	18.739	−2.173	1.00	11.54		N
  ATOM	1555	CA	ILE	G	266	39.282	19.820	−2.777	1.00	12.15		C
  ATOM	1556	CB	ILE	G	266	37.792	19.454	−2.914	1.00	12.22		C
  ATOM	1557	CG1	ILE	G	266	37.245	18.928	−1.585	1.00	12.53		C
  ATOM	1558	CD1	ILE	G	266	35.733	18.918	−1.510	1.00	12.40		C
  ATOM	1559	CG2	ILE	G	266	37.594	18.431	−4.023	1.00	12.74		C
  ATOM	1560	C	ILE	G	266	39.413	21.132	−2.013	1.00	12.29		C
  ATOM	1561	O	ILE	G	266	39.853	21.156	−0.863	1.00	12.36		O
  ATOM	1562	N	THR	G	267	39.034	22.223	−2.670	1.00	12.29		N
  ATOM	1563	CA	THR	G	267	39.039	23.541	−2.050	1.00	12.43		C
  ATOM	1564	CB	THR	G	267	38.564	24.627	−3.034	1.00	12.40		C
  ATOM	1565	OG1	THR	G	267	37.340	25.204	−2.562	1.00	13.21		O
  ATOM	1566	CG2	THR	G	267	38.341	24.033	−4.417	1.00	12.21		C
  ATOM	1567	C	THR	G	267	38.141	23.560	−0.819	1.00	12.37		C
  ATOM	1568	O	THR	G	267	37.440	22.589	−0.537	1.00	12.29		O
  ATOM	1569	N	ASN	G	268	38.174	24.664	−0.081	1.00	12.47		N
  ATOM	1570	CA	ASN	G	268	37.523	24.720	1.219	1.00	12.57		C
  ATOM	1571	CB	ASN	G	268	38.199	25.751	2.121	1.00	12.69		C
  ATOM	1572	CG	ASN	G	268	39.221	25.127	3.048	1.00	13.65		C
  ATOM	1573	OD1	ASN	G	268	39.463	23.921	3.000	1.00	14.37		O
  ATOM	1574	ND2	ASN	G	268	39.843	25.949	3.884	1.00	15.74		N
  ATOM	1575	C	ASN	G	268	36.028	24.995	1.123	1.00	12.43		C
  ATOM	1576	O	ASN	G	268	35.232	24.403	1.853	1.00	12.51		O
  ATOM	1577	N	ASP	G	269	35.655	25.926	0.252	1.00	12.34		N
  ATOM	1578	CA	ASP	G	269	34.248	26.218	0.008	1.00	12.33		C
  ATOM	1579	CB	ASP	G	269	34.106	27.359	−0.999	1.00	12.89		C
  ATOM	1580	CG	ASP	G	269	34.761	28.639	−0.525	1.00	14.84		C
  ATOM	1581	OD1	ASP	G	269	34.594	28.989	0.663	1.00	16.90		O
  ATOM	1582	OD2	ASP	G	269	35.473	29.277	−1.328	1.00	17.65		O
  ATOM	1583	C	ASP	G	269	33.532	24.978	−0.506	1.00	11.60		C
  ATOM	1584	O	ASP	G	269	32.411	24.679	−0.095	1.00	11.65		O
  ATOM	1585	N	GLN	G	270	34.189	24.260	−1.410	1.00	10.62		N
  ATOM	1586	CA	GLN	G	270	33.728	22.943	−1.816	1.00	10.01		C
  ATOM	1587	CB	GLN	G	270	34.795	22.236	−2.647	1.00	10.18		C
  ATOM	1588	CG	GLN	G	270	34.248	21.533	−3.870	1.00	11.49		C
  ATOM	1589	CD	GLN	G	270	35.200	21.598	−5.043	1.00	14.38		C
  ATOM	1590	OE1	GLN	G	270	35.516	20.579	−5.655	1.00	16.38		O
  ATOM	1591	NE2	GLN	G	270	35.718	22.789	−5.318	1.00	15.41		N
  ATOM	1592	C	GLN	G	270	33.366	22.094	−0.606	1.00	9.48		C
  ATOM	1593	O	GLN	G	270	32.213	21.698	−0.437	1.00	9.12		O
  ATOM	1594	N	LYS	G	271	34.358	21.809	0.231	1.00	9.19		N
  ATOM	1595	CA	LYS	G	271	34.126	21.040	1.445	1.00	8.89		C
  ATOM	1596	CB	LYS	G	271	35.362	21.070	2.345	1.00	8.52		C
  ATOM	1597	CG	LYS	G	271	36.541	20.285	1.797	1.00	9.14		C
  ATOM	1598	CD	LYS	G	271	37.643	20.147	2.832	1.00	10.72		C
  ATOM	1599	CE	LYS	G	271	39.013	20.137	2.176	1.00	10.79		C
  ATOM	1600	NZ	LYS	G	271	40.035	19.472	3.030	1.00	9.77		N
  ATOM	1601	C	LYS	G	271	32.907	21.563	2.199	1.00	8.83		C
  ATOM	1602	O	LYS	G	271	31.959	20.820	2.452	1.00	9.05		O
  ATOM	1603	N	LYS	G	272	32.899	22.863	2.474	1.00	8.65		N
  ATOM	1604	CA	LYS	G	272	31.789	23.482	3.187	1.00	8.50		C
  ATOM	1605	CB	LYS	G	272	31.997	24.992	3.304	1.00	9.14		C
  ATOM	1606	CG	LYS	G	272	30.762	25.748	3.766	1.00	11.58		C
  ATOM	1607	CD	LYS	G	272	30.925	27.246	3.575	1.00	15.78		C
  ATOM	1608	CE	LYS	G	272	29.995	28.021	4.492	1.00	17.65		C
  ATOM	1609	NZ	LYS	G	272	30.462	29.418	4.703	1.00	19.68		N
  ATOM	1610	C	LYS	G	272	30.458	23.191	2.503	1.00	7.88		C
  ATOM	1611	O	LYS	G	272	29.486	22.808	3.154	1.00	8.12		O
  ATOM	1612	N	LEU	G	273	30.408	23.416	1.194	1.00	6.95		N
  ATOM	1613	CA	LEU	G	273	29.217	23.104	0.413	1.00	5.70		C
  ATOM	1614	CB	LEU	G	273	29.469	23.344	−1.077	1.00	5.85		C
  ATOM	1615	CG	LEU	G	273	28.313	23.000	−2.020	1.00	4.65		C
  ATOM	1616	CD1	LEU	G	273	27.277	24.114	−2.032	1.00	4.57		C
  ATOM	1617	CD2	LEU	G	273	28.829	22.729	−3.425	1.00	3.69		C
  ATOM	1618	C	LEU	G	273	28.781	21.663	0.644	1.00	5.14		C
  ATOM	1619	O	LEU	G	273	27.678	21.409	1.128	1.00	5.25		O
  ATOM	1620	N	MET	G	274	29.665	20.724	0.327	1.00	4.52		N
  ATOM	1621	CA	MET	G	274	29.354	19.312	0.482	1.00	4.59		C
  ATOM	1622	CB	MET	G	274	30.573	18.454	0.152	1.00	4.35		C
  ATOM	1623	CG	MET	G	274	30.938	18.457	−1.319	1.00	4.50		C
  ATOM	1624	SD	MET	G	274	32.305	17.344	−1.679	1.00	5.51		S
  ATOM	1625	CE	MET	G	274	31.469	15.758	−1.633	1.00	5.26		C
  ATOM	1626	C	MET	G	274	28.864	19.014	1.893	1.00	5.18		C
  ATOM	1627	O	MET	G	274	27.893	18.280	2.075	1.00	5.61		O
  ATOM	1628	N	SER	G	275	29.457	19.689	2.875	1.00	5.89		N
  ATOM	1629	CA	SER	G	275	29.118	19.465	4.278	1.00	6.18		C
  ATOM	1630	CB	SER	G	275	30.161	20.108	5.194	1.00	6.33		C
  ATOM	1631	OG	SER	G	275	31.457	19.601	4.925	1.00	5.91		O
  ATOM	1632	C	SER	G	275	27.726	19.989	4.619	1.00	6.58		C
  ATOM	1633	O	SER	G	275	27.031	19.425	5.464	1.00	7.03		O
  ATOM	1634	N	ASN	G	276	27.313	21.054	3.940	1.00	7.07		N
  ATOM	1635	CA	ASN	G	276	25.979	21.606	4.140	1.00	7.86		C
  ATOM	1636	CB	ASN	G	276	25.987	23.126	3.942	1.00	8.34		C
  ATOM	1637	CG	ASN	G	276	26.343	23.881	5.214	1.00	9.77		C
  ATOM	1638	OD1	ASN	G	276	26.033	23.439	6.320	1.00	11.84		O
  ATOM	1639	ND2	ASN	G	276	26.964	25.044	5.057	1.00	11.15		N
  ATOM	1640	C	ASN	G	276	24.908	20.954	3.262	1.00	7.71		C
  ATOM	1641	O	ASN	G	276	23.780	21.442	3.191	1.00	7.84		O
  ATOM	1642	N	ASN	G	277	25.239	19.819	2.649	1.00	7.77		N
  ATOM	1643	CA	ASN	G	277	24.372	19.220	1.631	1.00	7.85		C
  ATOM	1644	CB	ASN	G	277	24.704	19.777	0.246	1.00	7.58		C
  ATOM	1645	CG	ASN	G	277	24.023	21.099	−0.027	1.00	8.29		C
  ATOM	1646	OD1	ASN	G	277	22.818	21.152	−0.272	1.00	9.04		O
  ATOM	1647	ND2	ASN	G	277	24.798	22.176	−0.008	1.00	9.57		N
  ATOM	1648	C	ASN	G	277	24.410	17.693	1.590	1.00	7.86		C
  ATOM	1649	O	ASN	G	277	24.154	17.089	0.549	1.00	7.85		O
  ATOM	1650	N	VAL	G	278	24.886	17.093	2.674	1.00	7.67		N
  ATOM	1651	CA	VAL	G	278	24.839	15.645	2.879	1.00	7.77		C
  ATOM	1652	CB	VAL	G	278	24.594	15.309	4.352	1.00	7.98		C
  ATOM	1653	CG1	VAL	G	278	25.915	15.261	5.100	1.00	7.21		C
  ATOM	1654	CG2	VAL	G	278	23.655	16.332	4.977	1.00	8.99		C
  ATOM	1655	C	VAL	G	278	23.843	14.865	2.019	1.00	7.76		C
  ATOM	1656	O	VAL	G	278	24.183	13.811	1.483	1.00	7.84		O
  ATOM	1657	N	GLN	G	279	22.569	15.228	2.118	1.00	7.47		N
  ATOM	1658	CA	GLN	G	279	21.510	14.444	1.492	1.00	7.07		C
  ATOM	1659	CB	GLN	G	279	20.187	15.204	1.550	1.00	7.62		C
  ATOM	1660	CG	GLN	G	279	19.021	14.376	2.044	1.00	10.35		C
  ATOM	1661	CD	GLN	G	279	17.682	14.997	1.702	1.00	13.70		C
  ATOM	1662	OE1	GLN	G	279	17.612	16.002	0.996	1.00	15.06		O
  ATOM	1663	NE2	GLN	G	279	16.607	14.383	2.179	1.00	13.97		N
  ATOM	1664	C	GLN	G	279	21.852	14.121	0.042	1.00	6.02		C
  ATOM	1665	O	GLN	G	279	22.032	12.958	−0.323	1.00	5.45		O
  ATOM	1666	N	ILE	G	280	21.863	15.154	−0.792	1.00	5.25		N
  ATOM	1667	CA	ILE	G	280	22.325	15.034	−2.169	1.00	4.74		C
  ATOM	1668	CB	ILE	G	280	22.650	16.408	−2.771	1.00	4.58		C
  ATOM	1669	CG1	ILE	G	280	21.527	17.396	−2.461	1.00	4.16		C
  ATOM	1670	CD1	ILE	G	280	20.235	17.078	−3.177	1.00	3.88		C
  ATOM	1671	CG2	ILE	G	280	22.835	16.293	−4.271	1.00	3.92		C
  ATOM	1672	C	ILE	G	280	23.550	14.135	−2.286	1.00	4.43		C
  ATOM	1673	O	ILE	G	280	23.493	13.081	−2.917	1.00	4.39		O
  ATOM	1674	N	VAL	G	281	24.676	14.596	−1.749	1.00	4.05		N
  ATOM	1675	CA	VAL	G	281	25.906	13.816	−1.795	1.00	3.58		C
  ATOM	1676	CB	VAL	G	281	26.918	14.251	−0.714	1.00	3.13		C
  ATOM	1677	CG1	VAL	G	281	28.296	13.684	−1.026	1.00	2.34		C
  ATOM	1678	CG2	VAL	G	281	26.978	15.768	−0.616	1.00	2.21		C
  ATOM	1679	C	VAL	G	281	25.593	12.335	−1.626	1.00	3.96		C
  ATOM	1680	O	VAL	G	281	25.875	11.534	−2.515	1.00	4.15		O
  ATOM	1681	N	ARG	G	282	24.908	11.994	−0.539	1.00	4.23		N
  ATOM	1682	CA	ARG	G	282	24.500	10.615	−0.296	1.00	4.45		C
  ATOM	1683	CB	ARG	G	282	23.570	10.540	0.911	1.00	3.96		C
  ATOM	1684	CG	ARG	G	282	24.225	10.953	2.203	1.00	2.99		C
  ATOM	1685	CD	ARG	G	282	23.924	9.962	3.303	1.00	2.28		C
  ATOM	1686	NE	ARG	G	282	24.332	10.474	4.605	1.00	2.00		N
  ATOM	1687	CZ	ARG	G	282	25.026	9.777	5.498	1.00	2.44		C
  ATOM	1688	NH1	ARG	G	282	25.359	8.517	5.251	1.00	2.04		N
  ATOM	1689	NH2	ARG	G	282	25.369	10.333	6.650	1.00	3.44		N
  ATOM	1690	C	ARG	G	282	23.798	10.039	−1.516	1.00	5.32		C
  ATOM	1691	O	ARG	G	282	24.143	8.958	−1.997	1.00	5.95		O
  ATOM	1692	N	GLN	G	283	22.800	10.765	−2.006	1.00	5.50		N
  ATOM	1693	CA	GLN	G	283	22.045	10.327	−3.169	1.00	5.80		C
  ATOM	1694	CB	GLN	G	283	20.910	11.303	−3.471	1.00	6.19		C
  ATOM	1695	CG	GLN	G	283	19.768	11.219	−2.480	1.00	9.68		C
  ATOM	1696	CD	GLN	G	283	18.840	12.406	−2.561	1.00	13.92		C
  ATOM	1697	OE1	GLN	G	283	18.991	13.269	−3.426	1.00	16.20		O
  ATOM	1698	NE2	GLN	G	283	17.833	12.428	−1.696	1.00	14.17		N
  ATOM	1699	C	GLN	G	283	22.953	10.175	−4.379	1.00	5.44		C
  ATOM	1700	O	GLN	G	283	22.687	9.364	−5.264	1.00	5.43		O
  ATOM	1701	N	GLN	G	284	24.067	10.896	−4.371	1.00	5.26		N
  ATOM	1702	CA	GLN	G	284	24.957	10.920	−5.521	1.00	5.18		C
  ATOM	1703	CB	GLN	G	284	25.568	12.307	−5.702	1.00	5.32		C
  ATOM	1704	CG	GLN	G	284	24.813	13.189	−6.673	1.00	6.85		C
  ATOM	1705	CD	GLN	G	284	25.434	14.560	−6.804	1.00	9.21		C
  ATOM	1706	OE1	GLN	G	284	25.863	15.160	−5.819	1.00	9.74		O
  ATOM	1707	NE2	GLN	G	284	25.492	15.064	−8.027	1.00	9.79		N
  ATOM	1708	C	GLN	G	284	26.060	9.882	−5.400	1.00	4.67		C
  ATOM	1709	O	GLN	G	284	26.884	9.736	−6.302	1.00	4.19		O
  ATOM	1710	N	SER	G	285	26.109	9.199	−4.262	1.00	4.51		N
  ATOM	1711	CA	SER	G	285	27.204	8.281	−3.990	1.00	4.39		C
  ATOM	1712	CB	SER	G	285	27.767	8.510	−2.587	1.00	4.13		C
  ATOM	1713	OG	SER	G	285	28.180	9.856	−2.421	1.00	4.40		O
  ATOM	1714	C	SER	G	285	26.767	6.834	−4.166	1.00	4.44		C
  ATOM	1715	O	SER	G	285	25.587	6.555	−4.382	1.00	4.82		O
  ATOM	1716	N	TYR	G	286	27.751	5.949	−4.271	1.00	4.53		N
  ATOM	1717	CA	TYR	G	286	27.500	4.517	−4.291	1.00	4.80		C
  ATOM	1718	CB	TYR	G	286	27.978	3.915	−5.612	1.00	4.88		C
  ATOM	1719	CG	TYR	G	286	27.168	4.354	−6.809	1.00	5.68		C
  ATOM	1720	CD1	TYR	G	286	27.156	5.681	−7.218	1.00	7.34		C
  ATOM	1721	CE1	TYR	G	286	26.429	6.081	−8.322	1.00	9.02		C
  ATOM	1722	CZ	TYR	G	286	25.720	5.145	−9.044	1.00	9.40		C
  ATOM	1723	OH	TYR	G	286	24.998	5.538	−10.146	1.00	10.44		O
  ATOM	1724	CE2	TYR	G	286	25.730	3.820	−8.668	1.00	9.38		C
  ATOM	1725	CD2	TYR	G	286	26.444	3.433	−7.553	1.00	7.39		C
  ATOM	1726	C	TYR	G	286	28.208	3.845	−3.124	1.00	4.76		C
  ATOM	1727	O	TYR	G	286	29.130	4.411	−2.541	1.00	5.25		O
  ATOM	1728	N	SER	G	287	27.765	2.642	−2.779	1.00	4.52		N
  ATOM	1729	CA	SER	G	287	28.528	1.786	−1.884	1.00	4.45		C
  ATOM	1730	CB	SER	G	287	27.888	1.743	−0.496	1.00	4.57		C
  ATOM	1731	OG	SER	G	287	28.421	0.681	0.275	1.00	4.38		O
  ATOM	1732	C	SER	G	287	28.670	0.381	−2.454	1.00	4.61		C
  ATOM	1733	O	SER	G	287	27.683	−0.253	−2.820	1.00	4.40		O
  ATOM	1734	N	ILE	G	288	29.914	−0.002	−2.717	1.00	5.11		N
  ATOM	1735	CA	ILE	G	288	30.227	−1.318	−3.258	1.00	5.81		C
  ATOM	1736	CB	ILE	G	288	31.376	−1.250	−4.288	1.00	5.52		C
  ATOM	1737	CG1	ILE	G	288	31.377	0.095	−5.021	1.00	5.47		C
  ATOM	1738	CD1	ILE	G	288	31.007	0.002	−6.487	1.00	6.23		C
  ATOM	1739	CG2	ILE	G	288	31.298	−2.421	−5.256	1.00	6.22		C
  ATOM	1740	C	ILE	G	288	30.664	−2.245	−2.138	1.00	6.71		C
  ATOM	1741	O	ILE	G	288	31.615	−1.948	−1.414	1.00	7.30		O
  ATOM	1742	N	MET	G	289	30.085	−3.438	−2.118	1.00	7.71		N
  ATOM	1743	CA	MET	G	289	30.585	−4.515	−1.277	1.00	8.57		C
  ATOM	1744	CB	MET	G	289	29.605	−5.692	−1.306	1.00	8.71		C
  ATOM	1745	CG	MET	G	289	29.648	−6.584	−0.077	1.00	9.70		C
  ATOM	1746	SD	MET	G	289	28.615	−8.046	−0.280	1.00	12.59		S
  ATOM	1747	CE	MET	G	289	29.227	−8.678	−1.839	1.00	12.41		C
  ATOM	1748	C	MET	G	289	31.975	−4.963	−1.736	1.00	9.12		C
  ATOM	1749	O	MET	G	289	32.231	−5.086	−2.935	1.00	9.31		O
  ATOM	1750	N	SER	G	290	32.891	−5.122	−0.784	1.00	9.80		N
  ATOM	1751	CA	SER	G	290	34.272	−5.469	−1.098	1.00	10.49		C
  ATOM	1752	CB	SER	G	290	35.242	−4.513	−0.401	1.00	10.64		C
  ATOM	1753	OG	SER	G	290	36.498	−4.486	−1.058	1.00	11.99		O
  ATOM	1754	C	SER	G	290	34.592	−6.918	−0.742	1.00	10.75		C
  ATOM	1755	O	SER	G	290	34.631	−7.778	−1.621	1.00	10.89		O
  ATOM	1756	N	ILE	G	291	34.760	−7.206	0.544	1.00	11.04		N
  ATOM	1757	CA	ILE	G	291	34.884	−8.596	0.965	1.00	11.41		C
  ATOM	1758	CB	ILE	G	291	36.329	−9.120	0.900	1.00	11.80		C
  ATOM	1759	CG1	ILE	G	291	37.332	−7.977	1.061	1.00	11.81		C
  ATOM	1760	CD1	ILE	G	291	38.227	−8.113	2.277	1.00	11.76		C
  ATOM	1761	CG2	ILE	G	291	36.561	−9.846	−0.416	1.00	12.39		C
  ATOM	1762	C	ILE	G	291	34.214	−8.982	2.277	1.00	11.13		C
  ATOM	1763	O	ILE	G	291	34.299	−8.268	3.277	1.00	10.55		O
  ATOM	1764	N	ILE	G	292	33.536	−10.124	2.246	1.00	11.36		N
  ATOM	1765	CA	ILE	G	292	32.802	−10.620	3.398	1.00	11.82		C
  ATOM	1766	CB	ILE	G	292	31.359	−11.016	3.029	1.00	11.86		C
  ATOM	1767	CG1	ILE	G	292	31.087	−10.734	1.550	1.00	13.42		C
  ATOM	1768	CD1	ILE	G	292	31.289	−9.282	1.158	1.00	15.86		C
  ATOM	1769	CG2	ILE	G	292	30.358	−10.287	3.923	1.00	10.85		C
  ATOM	1770	C	ILE	G	292	33.505	−11.826	3.992	1.00	11.72		C
  ATOM	1771	O	ILE	G	292	33.683	−12.849	3.330	1.00	11.28		O
  ATOM	1772	N	LYS	G	293	33.946	−11.679	5.234	1.00	12.11		N
  ATOM	1773	CA	LYS	G	293	34.275	−12.823	6.058	1.00	12.92		C
  ATOM	1774	CB	LYS	G	293	35.715	−12.720	6.553	1.00	13.15		C
  ATOM	1775	CG	LYS	G	293	36.674	−12.179	5.512	1.00	14.17		C
  ATOM	1776	CD	LYS	G	293	38.000	−12.910	5.561	1.00	15.37		C
  ATOM	1777	CE	LYS	G	293	38.720	−12.826	4.229	1.00	16.68		C
  ATOM	1778	NZ	LYS	G	293	39.984	−13.607	4.242	1.00	18.18		N
  ATOM	1779	C	LYS	G	293	33.310	−12.923	7.232	1.00	13.32		C
  ATOM	1780	O	LYS	G	293	32.633	−11.952	7.578	1.00	13.17		O
  ATOM	1781	N	GLU	G	294	33.140	−14.141	7.735	1.00	14.07		N
  ATOM	1782	CA	GLU	G	294	32.217	−14.398	8.831	1.00	15.07		C
  ATOM	1783	CB	GLU	G	294	32.474	−15.786	9.425	1.00	15.94		C
  ATOM	1784	CG	GLU	G	294	32.183	−16.935	8.471	1.00	19.87		C
  ATOM	1785	CD	GLU	G	294	32.165	−18.282	9.169	1.00	23.88		C
  ATOM	1786	OE1	GLU	G	294	31.348	−18.465	10.097	1.00	23.75		O
  ATOM	1787	OE2	GLU	G	294	32.950	−19.168	8.766	1.00	25.81		O
  ATOM	1788	C	GLU	G	294	32.301	−13.320	9.917	1.00	14.40		C
  ATOM	1789	O	GLU	G	294	31.281	−12.936	10.491	1.00	14.33		O
  ATOM	1790	N	GLU	G	295	33.502	−12.779	10.132	1.00	13.97		N
  ATOM	1791	CA	GLU	G	295	33.765	−11.861	11.251	1.00	13.84		C
  ATOM	1792	CB	GLU	G	295	34.681	−12.508	12.299	1.00	14.67		C
  ATOM	1793	CG	GLU	G	295	35.496	−13.688	11.794	1.00	17.56		C
  ATOM	1794	CD	GLU	G	295	36.393	−13.328	10.626	1.00	21.41		C
  ATOM	1795	OE1	GLU	G	295	36.085	−13.752	9.493	1.00	22.35		O
  ATOM	1796	OE2	GLU	G	295	37.472	−12.745	10.861	1.00	23.20		O
  ATOM	1797	C	GLU	G	295	34.340	−10.502	10.827	1.00	12.77		C
  ATOM	1798	O	GLU	G	295	34.771	−9.712	11.670	1.00	12.58		O
  ATOM	1799	N	VAL	G	296	34.389	−10.256	9.522	1.00	11.72		N
  ATOM	1800	CA	VAL	G	296	34.634	−8.911	9.011	1.00	10.65		C
  ATOM	1801	CB	VAL	G	296	36.143	−8.604	8.894	1.00	10.47		C
  ATOM	1802	CG1	VAL	G	296	36.369	−7.112	8.687	1.00	9.77		C
  ATOM	1803	CG2	VAL	G	296	36.879	−9.090	10.133	1.00	11.31		C
  ATOM	1804	C	VAL	G	296	33.949	−8.664	7.669	1.00	10.26		C
  ATOM	1805	O	VAL	G	296	33.931	−9.530	6.793	1.00	10.09		O
  ATOM	1806	N	LEU	G	297	33.379	−7.473	7.525	1.00	9.77		N
  ATOM	1807	CA	LEU	G	297	32.842	−7.027	6.250	1.00	8.97		C
  ATOM	1808	CB	LEU	G	297	31.332	−6.796	6.367	1.00	8.64		C
  ATOM	1809	CG	LEU	G	297	30.643	−6.020	5.243	1.00	9.01		C
  ATOM	1810	CD1	LEU	G	297	30.733	−6.773	3.927	1.00	9.79		C
  ATOM	1811	CD2	LEU	G	297	29.194	−5.752	5.606	1.00	9.43		C
  ATOM	1812	C	LEU	G	297	33.544	−5.745	5.821	1.00	8.34		C
  ATOM	1813	O	LEU	G	297	33.645	−4.793	6.595	1.00	8.64		O
  ATOM	1814	N	ALA	G	298	34.131	−5.767	4.631	1.00	7.21		N
  ATOM	1815	CA	ALA	G	298	34.751	−4.573	4.079	1.00	6.33		C
  ATOM	1816	CB	ALA	G	298	36.231	−4.800	3.860	1.00	6.68		C
  ATOM	1817	C	ALA	G	298	34.074	−4.177	2.778	1.00	5.85		C
  ATOM	1818	O	ALA	G	298	33.727	−5.033	1.965	1.00	5.96		O
  ATOM	1819	N	TYR	G	299	33.820	−2.883	2.620	1.00	5.28		N
  ATOM	1820	CA	TYR	G	299	33.178	−2.376	1.417	1.00	4.63		C
  ATOM	1821	CB	TYR	G	299	31.660	−2.340	1.595	1.00	4.36		C
  ATOM	1822	CG	TYR	G	299	31.204	−1.517	2.776	1.00	4.34		C
  ATOM	1823	CD1	TYR	G	299	30.967	−0.156	2.648	1.00	4.48		C
  ATOM	1824	CE1	TYR	G	299	30.505	0.592	3.717	1.00	4.55		C
  ATOM	1825	CZ	TYR	G	299	30.292	−0.019	4.937	1.00	3.72		C
  ATOM	1826	OH	TYR	G	299	29.847	0.720	6.009	1.00	2.38		O
  ATOM	1827	CE2	TYR	G	299	30.540	−1.366	5.092	1.00	4.13		C
  ATOM	1828	CD2	TYR	G	299	31.007	−2.102	4.020	1.00	4.38		C
  ATOM	1829	C	TYR	G	299	33.692	−0.988	1.063	1.00	4.32		C
  ATOM	1830	O	TYR	G	299	34.067	−0.214	1.944	1.00	4.67		O
  ATOM	1831	N	VAL	G	300	33.609	−0.641	−0.217	1.00	3.87		N
  ATOM	1832	CA	VAL	G	300	34.121	0.636	−0.696	1.00	3.57		C
  ATOM	1833	CB	VAL	G	300	34.892	0.481	−2.020	1.00	3.52		C
  ATOM	1834	CG1	VAL	G	300	35.278	1.843	−2.576	1.00	3.44		C
  ATOM	1835	CG2	VAL	G	300	36.127	−0.374	−1.808	1.00	3.90		C
  ATOM	1836	C	VAL	G	300	32.999	1.654	−0.861	1.00	3.53		C
  ATOM	1837	O	VAL	G	300	31.959	1.360	−1.451	1.00	3.68		O
  ATOM	1838	N	VAL	G	301	33.163	2.795	−0.205	1.00	3.41		N
  ATOM	1839	CA	VAL	G	301	32.321	3.950	−0.451	1.00	3.36		C
  ATOM	1840	CB	VAL	G	301	32.264	4.847	0.789	1.00	3.24		C
  ATOM	1841	CG1	VAL	G	301	31.738	6.229	0.428	1.00	3.76		C
  ATOM	1842	CG2	VAL	G	301	31.431	4.190	1.884	1.00	3.10		C
  ATOM	1843	C	VAL	G	301	32.854	4.766	−1.619	1.00	3.48		C
  ATOM	1844	O	VAL	G	301	34.065	4.911	−1.786	1.00	3.92		O
  ATOM	1845	N	GLN	G	302	31.943	5.410	−2.339	1.00	3.21		N
  ATOM	1846	CA	GLN	G	302	32.285	6.084	−3.578	1.00	3.01		C
  ATOM	1847	CB	GLN	G	302	31.901	5.213	−4.775	1.00	3.24		C
  ATOM	1848	CG	GLN	G	302	31.990	5.924	−6.113	1.00	5.21		C
  ATOM	1849	CD	GLN	G	302	32.153	4.963	−7.271	1.00	7.54		C
  ATOM	1850	OE1	GLN	G	302	32.555	3.814	−7.086	1.00	7.28		O
  ATOM	1851	NE2	GLN	G	302	31.793	5.412	−8.467	1.00	9.27		N
  ATOM	1852	C	GLN	G	302	31.571	7.424	−3.652	1.00	2.42		C
  ATOM	1853	O	GLN	G	302	30.344	7.479	−3.737	1.00	2.40		O
  ATOM	1854	N	LEU	G	303	32.323	8.492	−3.426	1.00	2.00		N
  ATOM	1855	CA	LEU	G	303	31.729	9.802	−3.232	1.00	2.00		C
  ATOM	1856	CB	LEU	G	303	32.303	10.471	−1.979	1.00	2.00		C
  ATOM	1857	CG	LEU	G	303	32.332	9.619	−0.706	1.00	2.00		C
  ATOM	1858	CD1	LEU	G	303	32.849	10.428	0.474	1.00	2.00		C
  ATOM	1859	CD2	LEU	G	303	30.960	9.033	−0.400	1.00	2.00		C
  ATOM	1860	C	LEU	G	303	31.955	10.674	−4.460	1.00	2.00		C
  ATOM	1861	O	LEU	G	303	32.835	10.391	−5.273	1.00	2.45		O
  ATOM	1862	N	PRO	G	304	31.136	11.723	−4.614	1.00	2.00		N
  ATOM	1863	CA	PRO	G	304	31.230	12.520	−5.827	1.00	2.07		C
  ATOM	1864	CB	PRO	G	304	29.999	13.432	−5.754	1.00	2.00		C
  ATOM	1865	CG	PRO	G	304	29.497	13.323	−4.348	1.00	2.00		C
  ATOM	1866	CD	PRO	G	304	29.880	11.966	−3.888	1.00	2.06		C
  ATOM	1867	C	PRO	G	304	32.513	13.340	−5.854	1.00	2.11		C
  ATOM	1868	O	PRO	G	304	32.814	14.030	−4.878	1.00	2.13		O
  ATOM	1869	N	ALA	G	305	33.407	12.935	−6.752	1.00	30.00		N
  ATOM	1870	CA	ALA	G	305	33.971	13.839	−7.760	1.00	30.00		C
  ATOM	1871	CB	ALA	G	305	35.427	13.480	−8.043	1.00	30.00		C
  ATOM	1872	C	ALA	G	305	33.151	13.838	−9.059	1.00	30.00		C
  ATOM	1873	O	ALA	G	305	32.743	12.775	−9.530	1.00	30.00		O
  ATOM	1874	N	TYR	G	306	32.752	15.032	−9.522	1.00	13.49		N
  ATOM	1875	CA	TYR	G	306	31.656	15.131	−10.505	1.00	13.70		C
  ATOM	1876	CB	TYR	G	306	30.892	16.462	−10.539	1.00	13.93		C
  ATOM	1877	CG	TYR	G	306	31.430	17.687	−9.879	1.00	14.08		C
  ATOM	1878	CD1	TYR	G	306	32.339	18.519	−10.551	1.00	14.59		C
  ATOM	1879	CE1	TYR	G	306	32.383	19.885	−10.286	1.00	14.82		C
  ATOM	1880	CZ	TYR	G	306	31.470	20.425	−9.404	1.00	14.52		C
  ATOM	1881	OH	TYR	G	306	31.626	21.709	−8.943	1.00	13.02		O
  ATOM	1882	CE2	TYR	G	306	30.465	19.645	−8.899	1.00	15.22		C
  ATOM	1883	CD2	TYR	G	306	30.596	18.296	−8.957	1.00	14.61		C
  ATOM	1884	C	TYR	G	306	32.048	14.998	−11.938	1.00	13.68		C
  ATOM	1885	O	TYR	G	306	33.051	14.374	−12.273	1.00	13.95		O
  ATOM	1886	N	GLY	G	307	31.521	16.002	−12.645	1.00	13.54		N
  ATOM	1887	CA	GLY	G	307	31.871	16.332	−14.033	1.00	13.37		C
  ATOM	1888	C	GLY	G	307	30.772	16.073	−15.065	1.00	13.47		C
  ATOM	1889	O	GLY	G	307	30.263	14.955	−15.138	1.00	13.90		O
  ATOM	1890	N	VAL	G	308	30.591	16.991	−16.021	1.00	13.31		N
  ATOM	1891	CA	VAL	G	308	29.883	16.654	−17.276	1.00	13.30		C
  ATOM	1892	CB	VAL	G	308	28.555	15.924	−16.985	1.00	13.03		C
  ATOM	1893	CG1	VAL	G	308	28.183	15.008	−18.138	1.00	13.62		C
  ATOM	1894	CG2	VAL	G	308	28.619	15.178	−15.665	1.00	12.86		C
  ATOM	1895	C	VAL	G	308	29.425	17.870	−18.046	1.00	13.58		C
  ATOM	1896	O	VAL	G	308	30.236	18.677	−18.508	1.00	13.71		O
  ATOM	1897	N	ILE	G	309	28.221	18.219	−17.643	1.00	4.08		N
  ATOM	1898	CA	ILE	G	309	28.140	19.052	−16.487	1.00	4.84		C
  ATOM	1899	CB	ILE	G	309	29.493	19.031	−15.728	1.00	4.89		C
  ATOM	1900	CG1	ILE	G	309	29.924	17.598	−15.412	1.00	5.85		C
  ATOM	1901	CD1	ILE	G	309	29.235	17.007	−14.197	1.00	8.12		C
  ATOM	1902	CG2	ILE	G	309	29.423	19.879	−14.473	1.00	4.44		C
  ATOM	1903	C	ILE	G	309	28.075	20.346	−17.222	1.00	5.23		C
  ATOM	1904	O	ILE	G	309	28.803	20.526	−18.199	1.00	5.92		O
  ATOM	1905	N	ASP	G	310	26.984	21.057	−17.020	1.00	5.33		N
  ATOM	1906	CA	ASP	G	310	26.985	22.446	−17.403	1.00	5.83		C
  ATOM	1907	CB	ASP	G	310	28.432	22.938	−17.554	1.00	6.21		C
  ATOM	1908	CG	ASP	G	310	29.280	22.660	−16.321	1.00	7.19		C
  ATOM	1909	OD1	ASP	G	310	30.432	22.200	−16.480	1.00	7.74		O
  ATOM	1910	OD2	ASP	G	310	28.844	23.021	−15.209	1.00	7.58		O
  ATOM	1911	C	ASP	G	310	26.233	22.676	−18.712	1.00	6.02		C
  ATOM	1912	O	ASP	G	310	26.323	23.760	−19.287	1.00	6.05		O
  ATOM	1913	N	THR	G	311	25.448	21.696	−19.157	1.00	6.24		N
  ATOM	1914	CA	THR	G	311	24.352	21.982	−20.088	1.00	6.14		C
  ATOM	1915	CB	THR	G	311	23.883	20.720	−20.852	1.00	5.69		C
  ATOM	1916	OG1	THR	G	311	24.925	19.737	−20.850	1.00	5.34		O
  ATOM	1917	CG2	THR	G	311	23.526	21.069	−22.291	1.00	7.10		C
  ATOM	1918	C	THR	G	311	23.160	22.578	−19.339	1.00	6.78		C
  ATOM	1919	O	THR	G	311	22.863	22.163	−18.218	1.00	7.33		O
  ATOM	1920	N	PRO	G	312	22.414	23.483	−19.992	1.00	7.00		N
  ATOM	1921	CA	PRO	G	312	21.205	23.982	−19.341	1.00	7.23		C
  ATOM	1922	CB	PRO	G	312	20.748	25.113	−20.267	1.00	7.00		C
  ATOM	1923	CG	PRO	G	312	21.341	24.786	−21.593	1.00	6.59		C
  ATOM	1924	CD	PRO	G	312	22.649	24.119	−21.300	1.00	6.99		C
  ATOM	1925	C	PRO	G	312	20.138	22.895	−19.263	1.00	7.69		C
  ATOM	1926	O	PRO	G	312	19.973	22.130	−20.213	1.00	7.55		O
  ATOM	1927	N	CYS	G	313	19.469	22.781	−18.120	1.00	8.10		N
  ATOM	1928	CA	CYS	G	313	18.164	22.128	−18.088	1.00	8.54		C
  ATOM	1929	CB	CYS	G	313	18.165	20.883	−17.192	1.00	8.77		C
  ATOM	1930	SG	CYS	G	313	19.762	20.065	−16.969	1.00	10.74		S
  ATOM	1931	C	CYS	G	313	17.029	23.057	−17.686	1.00	8.19		C
  ATOM	1932	O	CYS	G	313	17.246	24.212	−17.319	1.00	8.07		O
  ATOM	1933	N	TRP	G	314	15.832	22.485	−17.634	1.00	7.93		N
  ATOM	1934	CA	TRP	G	314	14.663	23.177	−17.125	1.00	7.80		C
  ATOM	1935	CB	TRP	G	314	14.110	24.131	−18.184	1.00	8.13		C
  ATOM	1936	CG	TRP	G	314	13.856	23.474	−19.505	1.00	9.09		C
  ATOM	1937	CD1	TRP	G	314	12.657	23.036	−19.985	1.00	10.26		C
  ATOM	1938	NE1	TRP	G	314	12.807	22.540	−21.257	1.00	10.86		N
  ATOM	1939	CE2	TRP	G	314	14.121	22.661	−21.628	1.00	10.68		C
  ATOM	1940	CD2	TRP	G	314	14.813	23.243	−20.547	1.00	10.49		C
  ATOM	1941	CE3	TRP	G	314	16.185	23.483	−20.675	1.00	11.67		C
  ATOM	1942	CZ3	TRP	G	314	16.814	23.119	−21.850	1.00	12.98		C
  ATOM	1943	CH2	TRP	G	314	16.104	22.513	−22.894	1.00	12.74		C
  ATOM	1944	CZ2	TRP	G	314	14.758	22.286	−22.807	1.00	11.73		C
  ATOM	1945	C	TRP	G	314	13.603	22.153	−16.742	1.00	7.34		C
  ATOM	1946	O	TRP	G	314	13.578	21.044	−17.275	1.00	7.47		O
  ATOM	1947	N	LYS	G	315	12.783	22.500	−15.757	1.00	6.75		N
  ATOM	1948	CA	LYS	G	315	11.667	21.654	−15.363	1.00	6.37		C
  ATOM	1949	CB	LYS	G	315	11.631	21.475	−13.844	1.00	6.38		C
  ATOM	1950	CG	LYS	G	315	10.746	20.331	−13.374	1.00	6.55		C
  ATOM	1951	CD	LYS	G	315	10.695	20.252	−11.854	1.00	8.01		C
  ATOM	1952	CE	LYS	G	315	9.848	19.077	−11.383	1.00	8.78		C
  ATOM	1953	NZ	LYS	G	315	9.177	19.368	−10.085	1.00	10.21		N
  ATOM	1954	C	LYS	G	315	10.348	22.231	−15.855	1.00	6.32		C
  ATOM	1955	O	LYS	G	315	10.123	23.441	−15.798	1.00	6.21		O
  ATOM	1956	N	LEU	G	316	9.529	21.370	−16.443	1.00	6.58		N
  ATOM	1957	CA	LEU	G	316	8.273	21.796	−17.027	1.00	7.02		C
  ATOM	1958	CB	LEU	G	316	8.140	21.253	−18.448	1.00	6.64		C
  ATOM	1959	CG	LEU	G	316	6.756	21.379	−19.086	1.00	6.21		C
  ATOM	1960	CD1	LEU	G	316	6.358	22.841	−19.221	1.00	5.94		C
  ATOM	1961	CD2	LEU	G	316	6.730	20.687	−20.439	1.00	6.57		C
  ATOM	1962	C	LEU	G	316	7.116	21.308	−16.172	1.00	7.77		C
  ATOM	1963	O	LEU	G	316	6.942	20.105	−15.976	1.00	8.47		O
  ATOM	1964	N	HIS	G	317	6.363	22.247	−15.613	1.00	8.05		N
  ATOM	1965	CA	HIS	G	317	5.073	21.923	−15.031	1.00	8.21		C
  ATOM	1966	CB	HIS	G	317	4.956	22.485	−13.614	1.00	9.04		C
  ATOM	1967	CG	HIS	G	317	6.260	22.565	−12.886	1.00	11.41		C
  ATOM	1968	ND1	HIS	G	317	6.606	21.691	−11.877	1.00	13.62		N
  ATOM	1969	CE1	HIS	G	317	7.781	22.035	−11.383	1.00	14.91		C
  ATOM	1970	NE2	HIS	G	317	8.208	23.105	−12.029	1.00	14.25		N
  ATOM	1971	CD2	HIS	G	317	7.271	23.462	−12.969	1.00	12.67		C
  ATOM	1972	C	HIS	G	317	3.943	22.453	−15.894	1.00	7.39		C
  ATOM	1973	O	HIS	G	317	4.132	23.381	−16.680	1.00	7.23		O
  ATOM	1974	N	THR	G	318	2.736	22.006	−15.580	1.00	7.11		N
  ATOM	1975	CA	THR	G	318	1.704	21.826	−16.583	1.00	6.56		C
  ATOM	1976	CB	THR	G	318	1.869	20.474	−17.309	1.00	6.28		C
  ATOM	1977	OG1	THR	G	318	2.413	20.694	−18.616	1.00	6.33		O
  ATOM	1978	CG2	THR	G	318	0.534	19.761	−17.435	1.00	6.52		C
  ATOM	1979	C	THR	G	318	0.349	21.865	−15.893	1.00	6.58		C
  ATOM	1980	O	THR	G	318	0.104	21.105	−14.958	1.00	6.67		O
  ATOM	1981	N	SER	G	319	−0.501	22.802	−16.301	1.00	6.81		N
  ATOM	1982	CA	SER	G	319	−1.840	22.911	−15.730	1.00	7.31		C
  ATOM	1983	CB	SER	G	319	−1.929	24.106	−14.779	1.00	7.14		C
  ATOM	1984	OG	SER	G	319	−3.255	24.292	−14.314	1.00	6.84		O
  ATOM	1985	C	SER	G	319	−2.922	23.006	−16.800	1.00	7.93		C
  ATOM	1986	O	SER	G	319	−2.717	23.624	−17.845	1.00	8.65		O
  ATOM	1987	N	PRO	G	320	−4.104	22.440	−16.514	1.00	8.08		N
  ATOM	1988	CA	PRO	G	320	−5.172	22.399	−17.500	1.00	8.34		C
  ATOM	1989	CB	PRO	G	320	−6.336	21.738	−16.743	1.00	7.99		C
  ATOM	1990	CG	PRO	G	320	−5.908	21.662	−15.304	1.00	8.01		C
  ATOM	1991	CD	PRO	G	320	−4.422	21.635	−15.324	1.00	8.10		C
  ATOM	1992	C	PRO	G	320	−5.564	23.793	−17.984	1.00	9.03		C
  ATOM	1993	O	PRO	G	320	−5.261	24.788	−17.325	1.00	8.74		O
  ATOM	1994	N	LEU	G	321	−6.134	23.854	−19.184	1.00	10.31		N
  ATOM	1995	CA	LEU	G	321	−6.366	25.113	−19.885	1.00	11.63		C
  ATOM	1996	CB	LEU	G	321	−5.207	25.402	−20.848	1.00	11.31		C
  ATOM	1997	CG	LEU	G	321	−4.949	26.848	−21.291	1.00	10.97		C
  ATOM	1998	CD1	LEU	G	321	−4.174	26.884	−22.600	1.00	10.04		C
  ATOM	1999	CD2	LEU	G	321	−6.241	27.639	−21.416	1.00	10.69		C
  ATOM	2000	C	LEU	G	321	−7.683	25.027	−20.662	1.00	12.92		C
  ATOM	2001	O	LEU	G	321	−7.890	24.095	−21.439	1.00	13.29		O
  ATOM	2002	N	CYS	G	322	−8.593	25.964	−20.400	1.00	13.39		N
  ATOM	2003	CA	CYS	G	322	−9.923	25.955	−21.017	1.00	14.16		C
  ATOM	2004	CB	CYS	G	322	−10.994	25.588	−19.990	1.00	13.72		C
  ATOM	2005	SG	CYS	G	322	−10.587	24.180	−18.943	1.00	13.42		S
  ATOM	2006	C	CYS	G	322	−10.274	27.299	−21.650	1.00	15.46		C
  ATOM	2007	O	CYS	G	322	−10.048	28.352	−21.054	1.00	15.94		O
  ATOM	2008	N	THR	G	323	−10.985	27.241	−22.773	1.00	16.70		N
  ATOM	2009	CA	THR	G	323	−11.694	28.395	−23.326	1.00	17.84		C
  ATOM	2010	CB	THR	G	323	−12.389	28.017	−24.647	1.00	17.50		C
  ATOM	2011	OG1	THR	G	323	−12.703	26.618	−24.638	1.00	15.70		O
  ATOM	2012	CG2	THR	G	323	−11.486	28.322	−25.831	1.00	18.05		C
  ATOM	2013	C	THR	G	323	−12.756	28.915	−22.359	1.00	19.54		C
  ATOM	2014	O	THR	G	323	−13.178	28.188	−21.461	1.00	19.84		O
  ATOM	2015	N	THR	G	324	−13.354	30.061	−22.684	1.00	21.17		N
  ATOM	2016	CA	THR	G	324	−14.592	30.460	−22.017	1.00	22.89		C
  ATOM	2017	CB	THR	G	324	−14.343	31.388	−20.821	1.00	22.69		C
  ATOM	2018	OG1	THR	G	324	−12.937	31.469	−20.560	1.00	22.10		O
  ATOM	2019	CG2	THR	G	324	−15.061	30.857	−19.587	1.00	22.03		C
  ATOM	2020	C	THR	G	324	−15.712	31.033	−22.885	1.00	24.39		C
  ATOM	2021	O	THR	G	324	−16.838	31.194	−22.414	1.00	24.53		O
  ATOM	2022	N	ASN	G	325	−15.427	31.299	−24.155	1.00	25.72		N
  ATOM	2023	CA	ASN	G	325	−16.490	31.473	−25.144	1.00	27.01		C
  ATOM	2024	CB	ASN	G	325	−16.986	32.922	−25.170	1.00	27.37		C
  ATOM	2025	CG	ASN	G	325	−18.079	33.184	−24.148	1.00	28.46		C
  ATOM	2026	OD1	ASN	G	325	−19.267	33.164	−24.471	1.00	30.37		O
  ATOM	2027	ND2	ASN	G	325	−17.678	33.444	−22.909	1.00	28.78		N
  ATOM	2028	C	ASN	G	325	−16.075	31.032	−26.543	1.00	27.36		C
  ATOM	2029	O	ASN	G	325	−14.887	30.902	−26.837	1.00	27.94		O
  ATOM	2030	N	SER	G	330	−15.165	27.730	−23.322	1.00	35.76		N
  ATOM	2031	CA	SER	G	330	−16.301	26.817	−23.281	1.00	35.01		C
  ATOM	2032	CB	SER	G	330	−17.459	27.366	−24.117	1.00	35.47		C
  ATOM	2033	OG	SER	G	330	−17.137	27.368	−25.497	1.00	33.31		O
  ATOM	2034	C	SER	G	330	−15.906	25.431	−23.779	1.00	34.35		C
  ATOM	2035	O	SER	G	330	−15.111	25.299	−24.709	1.00	34.33		O
  ATOM	2036	N	ASN	G	331	−16.430	24.399	−23.128	1.00	32.48		N
  ATOM	2037	CA	ASN	G	331	−16.609	23.102	−23.770	1.00	30.72		C
  ATOM	2038	CB	ASN	G	331	−17.432	23.247	−25.060	1.00	31.31		C
  ATOM	2039	CG	ASN	G	331	−18.924	23.445	−24.801	1.00	32.11		C
  ATOM	2040	OD1	ASN	G	331	−19.426	23.149	−23.716	1.00	32.54		O
  ATOM	2041	ND2	ASN	G	331	−19.651	23.849	−25.838	1.00	31.30		N
  ATOM	2042	C	ASN	G	331	−15.298	22.357	−24.074	1.00	28.71		C
  ATOM	2043	O	ASN	G	331	−15.322	21.324	−24.741	1.00	29.07		O
  ATOM	2044	N	ILE	G	332	−14.155	22.896	−23.649	1.00	25.44		N
  ATOM	2045	CA	ILE	G	332	−12.868	22.313	−24.053	1.00	21.83		C
  ATOM	2046	CB	ILE	G	332	−12.546	22.613	−25.536	1.00	21.42		C
  ATOM	2047	CG1	ILE	G	332	−11.286	21.867	−25.981	1.00	19.89		C
  ATOM	2048	CD1	ILE	G	332	−11.573	20.576	−26.724	1.00	17.67		C
  ATOM	2049	CG2	ILE	G	332	−12.428	24.111	−25.776	1.00	20.61		C
  ATOM	2050	C	ILE	G	332	−11.667	22.657	−23.162	1.00	20.37		C
  ATOM	2051	O	ILE	G	332	−11.388	23.829	−22.903	1.00	19.95		O
  ATOM	2052	N	CYS	G	333	−10.896	21.634	−22.794	1.00	18.27		N
  ATOM	2053	CA	CYS	G	333	−9.666	21.842	−22.031	1.00	16.47		C
  ATOM	2054	CB	CYS	G	333	−9.923	21.703	−20.529	1.00	16.14		C
  ATOM	2055	SG	CYS	G	333	−11.374	22.595	−19.936	1.00	17.09		S
  ATOM	2056	C	CYS	G	333	−8.480	20.967	−22.450	1.00	15.73		C
  ATOM	2057	O	CYS	G	333	−8.652	19.820	−22.871	1.00	15.43		O
  ATOM	2058	N	LEU	G	334	−7.298	21.425	−22.047	1.00	15.06		N
  ATOM	2059	CA	LEU	G	334	−6.022	20.883	−22.498	1.00	13.79		C
  ATOM	2060	CB	LEU	G	334	−5.346	21.857	−23.472	1.00	13.39		C
  ATOM	2061	CG	LEU	G	334	−5.891	21.998	−24.895	1.00	13.93		C
  ATOM	2062	CD1	LEU	G	334	−4.764	22.327	−25.858	1.00	14.20		C
  ATOM	2063	CD2	LEU	G	334	−6.617	20.739	−25.331	1.00	14.52		C
  ATOM	2064	C	LEU	G	334	−5.142	20.748	−21.263	1.00	13.22		C
  ATOM	2065	O	LEU	G	334	−5.033	21.685	−20.472	1.00	13.31		O
  ATOM	2066	N	THR	G	335	−4.417	19.640	−21.169	1.00	12.58		N
  ATOM	2067	CA	THR	G	335	−3.277	19.561	−20.268	1.00	12.17		C
  ATOM	2068	CB	THR	G	335	−3.612	18.748	−19.001	1.00	12.02		C
  ATOM	2069	OG1	THR	G	335	−5.021	18.815	−18.744	1.00	12.64		O
  ATOM	2070	CG2	THR	G	335	−2.858	19.295	−17.803	1.00	11.47		C
  ATOM	2071	C	THR	G	335	−2.093	18.930	−20.986	1.00	11.97		C
  ATOM	2072	O	THR	G	335	−2.258	17.980	−21.751	1.00	11.93		O
  ATOM	2073	N	ARG	G	336	−0.942	19.586	−20.892	1.00	11.60		N
  ATOM	2074	CA	ARG	G	336	0.254	19.122	−21.578	1.00	12.15		C
  ATOM	2075	CB	ARG	G	336	1.293	20.239	−21.640	1.00	12.16		C
  ATOM	2076	CG	ARG	G	336	2.162	20.208	−22.879	1.00	12.67		C
  ATOM	2077	CD	ARG	G	336	2.261	21.590	−23.500	1.00	12.52		C
  ATOM	2078	NE	ARG	G	336	3.341	22.374	−22.912	1.00	12.35		N
  ATOM	2079	CZ	ARG	G	336	4.632	22.136	−23.117	1.00	12.54		C
  ATOM	2080	NH1	ARG	G	336	5.006	21.109	−23.867	1.00	12.38		N
  ATOM	2081	NH2	ARG	G	336	5.549	22.904	−22.545	1.00	12.48		N
  ATOM	2082	C	ARG	G	336	0.841	17.907	−20.872	1.00	12.71		C
  ATOM	2083	O	ARG	G	336	1.185	17.974	−19.693	1.00	12.62		O
  ATOM	2084	N	THR	G	337	0.885	16.779	−21.574	1.00	13.70		N
  ATOM	2085	CA	THR	G	337	1.284	15.514	−20.964	1.00	14.91		C
  ATOM	2086	CB	THR	G	337	1.084	14.331	−21.931	1.00	15.27		C
  ATOM	2087	OG1	THR	G	337	−0.264	14.329	−22.421	1.00	16.65		O
  ATOM	2088	CG2	THR	G	337	1.370	13.015	−21.226	1.00	15.94		C
  ATOM	2089	C	THR	G	337	2.744	15.546	−20.519	1.00	15.16		C
  ATOM	2090	O	THR	G	337	3.069	15.159	−19.396	1.00	15.60		O
  ATOM	2091	N	ASP	G	338	3.623	15.968	−21.424	1.00	15.15		N
  ATOM	2092	CA	ASP	G	338	5.055	15.721	−21.283	1.00	15.52		C
  ATOM	2093	CB	ASP	G	338	5.781	15.935	−22.613	1.00	16.81		C
  ATOM	2094	CG	ASP	G	338	5.051	16.899	−23.529	1.00	20.57		C
  ATOM	2095	OD1	ASP	G	338	5.160	16.744	−24.763	1.00	23.00		O
  ATOM	2096	OD2	ASP	G	338	4.290	17.747	−23.017	1.00	22.92		O
  ATOM	2097	C	ASP	G	338	5.674	16.595	−20.201	1.00	14.21		C
  ATOM	2098	O	ASP	G	338	6.235	17.654	−20.486	1.00	14.00		O
  ATOM	2099	N	ARG	G	339	5.617	16.113	−18.965	1.00	12.79		N
  ATOM	2100	CA	ARG	G	339	6.087	16.877	−17.822	1.00	11.71		C
  ATOM	2101	CB	ARG	G	339	5.108	16.747	−16.665	1.00	11.73		C
  ATOM	2102	CG	ARG	G	339	3.773	17.383	−16.931	1.00	12.49		C
  ATOM	2103	CD	ARG	G	339	3.116	17.761	−15.633	1.00	13.24		C
  ATOM	2104	NE	ARG	G	339	1.712	17.370	−15.607	1.00	12.04		N
  ATOM	2105	CZ	ARG	G	339	0.844	17.804	−14.703	1.00	11.74		C
  ATOM	2106	NH1	ARG	G	339	1.259	18.579	−13.710	1.00	13.43		N
  ATOM	2107	NH2	ARG	G	339	−0.427	17.428	−14.759	1.00	9.80		N
  ATOM	2108	C	ARG	G	339	7.443	16.388	−17.365	1.00	11.16		C
  ATOM	2109	O	ARG	G	339	7.703	15.185	−17.376	1.00	11.37		O
  ATOM	2110	N	GLY	G	340	8.141	17.269	−16.660	1.00	10.43		N
  ATOM	2111	CA	GLY	G	340	9.340	16.886	−15.933	1.00	9.52		C
  ATOM	2112	C	GLY	G	340	10.559	17.608	−16.465	1.00	8.80		C
  ATOM	2113	O	GLY	G	340	10.475	18.759	−16.903	1.00	8.56		O
  ATOM	2114	N	TRP	G	341	11.700	16.935	−16.411	1.00	8.25		N
  ATOM	2115	CA	TRP	G	341	12.965	17.581	−16.704	1.00	7.98		C
  ATOM	2116	CB	TRP	G	341	14.089	16.966	−15.879	1.00	7.79		C
  ATOM	2117	CG	TRP	G	341	14.110	17.460	−14.478	1.00	7.67		C
  ATOM	2118	CD1	TRP	G	341	13.519	16.869	−13.399	1.00	8.12		C
  ATOM	2119	NE1	TRP	G	341	13.686	17.648	−12.283	1.00	8.60		N
  ATOM	2120	CE2	TRP	G	341	14.304	18.815	−12.649	1.00	7.57		C
  ATOM	2121	CD2	TRP	G	341	14.536	18.754	−14.037	1.00	7.52		C
  ATOM	2122	CE3	TRP	G	341	15.176	19.830	−14.663	1.00	7.86		C
  ATOM	2123	CZ3	TRP	G	341	15.535	20.925	−13.898	1.00	7.14		C
  ATOM	2124	CH2	TRP	G	341	15.279	20.962	−12.521	1.00	6.39		C
  ATOM	2125	CZ2	TRP	G	341	14.663	19.919	−11.880	1.00	7.30		C
  ATOM	2126	C	TRP	G	341	13.286	17.490	−18.180	1.00	8.26		C
  ATOM	2127	O	TRP	G	341	13.320	16.402	−18.755	1.00	8.35		O
  ATOM	2128	N	TYR	G	342	13.400	18.649	−18.811	1.00	8.44		N
  ATOM	2129	CA	TYR	G	342	14.197	18.777	−20.012	1.00	8.53		C
  ATOM	2130	CB	TYR	G	342	13.486	19.670	−21.015	1.00	8.43		C
  ATOM	2131	CG	TYR	G	342	12.099	19.192	−21.318	1.00	9.17		C
  ATOM	2132	CD1	TYR	G	342	11.097	19.299	−20.363	1.00	10.32		C
  ATOM	2133	CE1	TYR	G	342	9.849	18.765	−20.582	1.00	10.99		C
  ATOM	2134	CZ	TYR	G	342	9.618	18.033	−21.724	1.00	11.00		C
  ATOM	2135	OH	TYR	G	342	8.365	17.521	−21.964	1.00	12.82		O
  ATOM	2136	CE2	TYR	G	342	10.626	17.838	−22.643	1.00	10.67		C
  ATOM	2137	CD2	TYR	G	342	11.871	18.365	−22.403	1.00	10.41		C
  ATOM	2138	C	TYR	G	342	15.550	19.359	−19.680	1.00	8.64		C
  ATOM	2139	O	TYR	G	342	15.754	19.906	−18.596	1.00	8.40		O
  ATOM	2140	N	CYS	G	343	16.460	19.284	−20.641	1.00	8.87		N
  ATOM	2141	CA	CYS	G	343	17.875	19.346	−20.332	1.00	9.35		C
  ATOM	2142	CB	CYS	G	343	18.190	18.501	−19.092	1.00	9.17		C
  ATOM	2143	SG	CYS	G	343	19.879	18.684	−18.466	1.00	11.88		S
  ATOM	2144	C	CYS	G	343	18.722	18.920	−21.524	1.00	9.42		C
  ATOM	2145	O	CYS	G	343	18.505	17.856	−22.103	1.00	9.96		O
  ATOM	2146	N	ASP	G	344	19.534	19.857	−22.005	1.00	9.36		N
  ATOM	2147	CA	ASP	G	344	20.127	19.778	−23.338	1.00	9.24		C
  ATOM	2148	CB	ASP	G	344	20.797	21.108	−23.703	1.00	9.34		C
  ATOM	2149	CG	ASP	G	344	19.874	22.037	−24.474	1.00	10.72		C
  ATOM	2150	OD1	ASP	G	344	19.475	21.677	−25.602	1.00	13.93		O
  ATOM	2151	OD2	ASP	G	344	19.548	23.127	−23.954	1.00	11.87		O
  ATOM	2152	C	ASP	G	344	21.148	18.651	−23.425	1.00	9.09		C
  ATOM	2153	O	ASP	G	344	22.100	18.605	−22.646	1.00	9.39		O
  ATOM	2154	N	ASN	G	345	21.038	17.843	−24.474	1.00	9.13		N
  ATOM	2155	CA	ASN	G	345	22.114	16.939	−24.849	1.00	9.52		C
  ATOM	2156	CB	ASN	G	345	21.589	15.509	−24.978	1.00	9.61		C
  ATOM	2157	CG	ASN	G	345	22.640	14.472	−24.643	1.00	9.21		C
  ATOM	2158	OD1	ASN	G	345	23.121	14.400	−23.512	1.00	6.21		O
  ATOM	2159	ND2	ASN	G	345	23.032	13.685	−25.638	1.00	11.05		N
  ATOM	2160	C	ASN	G	345	22.772	17.381	−26.149	1.00	10.06		C
  ATOM	2161	O	ASN	G	345	22.506	18.476	−26.644	1.00	11.10		O
  ATOM	2162	N	ALA	G	346	23.644	16.539	−26.692	1.00	9.74		N
  ATOM	2163	CA	ALA	G	346	24.410	16.904	−27.877	1.00	9.58		C
  ATOM	2164	CB	ALA	G	346	25.241	15.723	−28.356	1.00	9.60		C
  ATOM	2165	C	ALA	G	346	23.498	17.406	−28.994	1.00	9.66		C
  ATOM	2166	O	ALA	G	346	22.977	16.618	−29.782	1.00	9.39		O
  ATOM	2167	N	GLY	G	347	23.290	18.720	−29.038	1.00	10.04		N
  ATOM	2168	CA	GLY	G	347	22.598	19.358	−30.157	1.00	10.68		C
  ATOM	2169	C	GLY	G	347	21.105	19.098	−30.137	1.00	10.90		C
  ATOM	2170	O	GLY	G	347	20.366	19.569	−31.002	1.00	11.46		O
  ATOM	2171	N	SER	G	348	20.691	18.235	−29.219	1.00	10.30		N
  ATOM	2172	CA	SER	G	348	19.301	17.838	−29.098	1.00	9.94		C
  ATOM	2173	CB	SER	G	348	19.103	16.421	−29.639	1.00	9.88		C
  ATOM	2174	OG	SER	G	348	19.440	16.352	−31.013	1.00	10.09		O
  ATOM	2175	C	SER	G	348	18.950	17.883	−27.624	1.00	9.60		C
  ATOM	2176	O	SER	G	348	19.775	18.267	−26.796	1.00	9.59		O
  ATOM	2177	N	VAL	G	349	17.723	17.505	−27.292	1.00	9.54		N
  ATOM	2178	CA	VAL	G	349	17.254	17.643	−25.925	1.00	9.56		C
  ATOM	2179	CB	VAL	G	349	16.091	18.639	−25.823	1.00	9.28		C
  ATOM	2180	CG1	VAL	G	349	15.814	18.985	−24.360	1.00	9.24		C
  ATOM	2181	CG2	VAL	G	349	16.391	19.892	−26.641	1.00	9.94		C
  ATOM	2182	C	VAL	G	349	16.824	16.309	−25.341	1.00	9.59		C
  ATOM	2183	O	VAL	G	349	16.029	15.585	−25.939	1.00	9.69		O
  ATOM	2184	N	SER	G	350	17.288	16.029	−24.130	1.00	9.93		N
  ATOM	2185	CA	SER	G	350	16.915	14.800	−23.451	1.00	10.44		C
  ATOM	2186	CB	SER	G	350	18.146	14.108	−22.858	1.00	10.04		C
  ATOM	2187	OG	SER	G	350	18.768	13.261	−23.812	1.00	8.41		O
  ATOM	2188	C	SER	G	350	15.854	15.039	−22.381	1.00	11.45		C
  ATOM	2189	O	SER	G	350	15.882	16.041	−21.665	1.00	11.58		O
  ATOM	2190	N	PHE	G	351	14.893	14.126	−22.318	1.00	12.28		N
  ATOM	2191	CA	PHE	G	351	13.722	14.291	−21.469	1.00	13.04		C
  ATOM	2192	CB	PHE	G	351	12.468	14.485	−22.321	1.00	12.87		C
  ATOM	2193	CG	PHE	G	351	11.192	14.388	−21.539	1.00	13.52		C
  ATOM	2194	CD1	PHE	G	351	11.026	15.127	−20.378	1.00	13.76		C
  ATOM	2195	CE1	PHE	G	351	9.857	15.044	−19.648	1.00	14.10		C
  ATOM	2196	CZ	PHE	G	351	8.855	14.175	−20.045	1.00	14.07		C
  ATOM	2197	CE2	PHE	G	351	9.028	13.395	−21.172	1.00	14.14		C
  ATOM	2198	CD2	PHE	G	351	10.202	13.489	−21.903	1.00	13.92		C
  ATOM	2199	C	PHE	G	351	13.526	13.082	−20.563	1.00	13.84		C
  ATOM	2200	O	PHE	G	351	13.246	11.979	−21.038	1.00	13.96		O
  ATOM	2201	N	PHE	G	352	13.463	13.340	−19.263	1.00	14.72		N
  ATOM	2202	CA	PHE	G	352	13.315	12.275	−18.286	1.00	15.98		C
  ATOM	2203	CB	PHE	G	352	14.429	12.360	−17.243	1.00	15.75		C
  ATOM	2204	CG	PHE	G	352	15.720	12.912	−17.780	1.00	15.51		C
  ATOM	2205	CD1	PHE	G	352	15.899	14.279	−17.924	1.00	15.05		C
  ATOM	2206	CE1	PHE	G	352	17.098	14.793	−18.375	1.00	14.05		C
  ATOM	2207	CZ	PHE	G	352	18.126	13.938	−18.719	1.00	13.28		C
  ATOM	2208	CE2	PHE	G	352	17.948	12.570	−18.615	1.00	13.71		C
  ATOM	2209	CD2	PHE	G	352	16.745	12.064	−18.163	1.00	14.94		C
  ATOM	2210	C	PHE	G	352	11.952	12.360	−17.612	1.00	17.56		C
  ATOM	2211	O	PHE	G	352	11.591	13.401	−17.066	1.00	17.74		O
  ATOM	2212	N	PRO	G	353	11.165	11.280	−17.705	1.00	19.05		N
  ATOM	2213	CA	PRO	G	353	9.719	11.355	−17.537	1.00	20.40		C
  ATOM	2214	CB	PRO	G	353	9.220	10.060	−18.189	1.00	20.26		C
  ATOM	2215	CG	PRO	G	353	10.352	9.587	−19.046	1.00	19.71		C
  ATOM	2216	CD	PRO	G	353	11.580	10.012	−18.325	1.00	18.97		C
  ATOM	2217	C	PRO	G	353	9.291	11.404	−16.072	1.00	21.94		C
  ATOM	2218	O	PRO	G	353	8.222	11.935	−15.768	1.00	22.29		O
  ATOM	2219	N	GLN	G	354	10.105	10.851	−15.175	1.00	23.38		N
  ATOM	2220	CA	GLN	G	354	9.731	10.792	−13.761	1.00	24.64		C
  ATOM	2221	CB	GLN	G	354	9.107	9.440	−13.400	1.00	24.93		C
  ATOM	2222	CG	GLN	G	354	9.407	8.322	−14.376	1.00	26.00		C
  ATOM	2223	CD	GLN	G	354	10.859	7.909	−14.354	1.00	25.92		C
  ATOM	2224	OE1	GLN	G	354	11.380	7.473	−13.327	1.00	25.67		O
  ATOM	2225	NE2	GLN	G	354	11.521	8.030	−15.498	1.00	24.27		N
  ATOM	2226	C	GLN	G	354	10.823	11.177	−12.759	1.00	24.85		C
  ATOM	2227	O	GLN	G	354	12.009	10.943	−12.989	1.00	24.51		O
  ATOM	2228	N	ALA	G	355	10.392	11.709	−11.618	1.00	25.22		N
  ATOM	2229	CA	ALA	G	355	11.296	12.264	−10.619	1.00	25.34		C
  ATOM	2230	CB	ALA	G	355	10.565	12.449	−9.296	1.00	25.09		C
  ATOM	2231	C	ALA	G	355	12.531	11.390	−10.427	1.00	24.92		C
  ATOM	2232	O	ALA	G	355	13.646	11.791	−10.766	1.00	25.23		O
  ATOM	2233	N	GLU	G	356	12.339	10.258	−9.755	1.00	23.93		N
  ATOM	2234	CA	GLU	G	356	13.282	9.141	−9.803	1.00	22.77		C
  ATOM	2235	CB	GLU	G	356	12.642	7.925	−10.474	1.00	23.22		C
  ATOM	2236	CG	GLU	G	356	11.489	7.338	−9.681	1.00	26.33		C
  ATOM	2237	CD	GLU	G	356	11.607	7.632	−8.199	1.00	30.93		C
  ATOM	2238	OE1	GLU	G	356	11.148	8.711	−7.764	1.00	31.97		O
  ATOM	2239	OE2	GLU	G	356	12.276	6.846	−7.494	1.00	32.21		O
  ATOM	2240	C	GLU	G	356	14.591	9.493	−10.492	1.00	21.31		C
  ATOM	2241	O	GLU	G	356	15.656	9.462	−9.876	1.00	21.01		O
  ATOM	2242	N	THR	G	357	14.511	9.752	−11.791	1.00	19.51		N
  ATOM	2243	CA	THR	G	357	15.690	9.787	−12.639	1.00	17.55		C
  ATOM	2244	CB	THR	G	357	15.305	9.928	−14.114	1.00	17.30		C
  ATOM	2245	OG1	THR	G	357	13.908	9.660	−14.273	1.00	17.32		O
  ATOM	2246	CG2	THR	G	357	16.099	8.958	−14.957	1.00	17.72		C
  ATOM	2247	C	THR	G	357	16.596	10.949	−12.262	1.00	16.62		C
  ATOM	2248	O	THR	G	357	17.761	10.991	−12.655	1.00	17.29		O
  ATOM	2249	N	CYS	G	358	16.028	11.935	−11.579	1.00	14.88		N
  ATOM	2250	CA	CYS	G	358	16.684	13.225	−11.440	1.00	13.15		C
  ATOM	2251	CB	CYS	G	358	16.025	14.262	−12.349	1.00	13.04		C
  ATOM	2252	SG	CYS	G	358	16.175	13.900	−14.114	1.00	14.02		S
  ATOM	2253	C	CYS	G	358	16.711	13.714	−9.997	1.00	12.08		C
  ATOM	2254	O	CYS	G	358	15.705	13.661	−9.289	1.00	12.15		O
  ATOM	2255	N	LYS	G	359	17.890	14.140	−9.554	1.00	11.35		N
  ATOM	2256	CA	LYS	G	359	18.024	14.888	−8.311	1.00	11.01		C
  ATOM	2257	CB	LYS	G	359	18.968	14.165	−7.353	1.00	11.16		C
  ATOM	2258	CG	LYS	G	359	19.450	12.824	−7.857	1.00	13.28		C
  ATOM	2259	CD	LYS	G	359	19.029	11.720	−6.912	1.00	16.11		C
  ATOM	2260	CE	LYS	G	359	19.561	10.378	−7.366	1.00	17.91		C
  ATOM	2261	NZ	LYS	G	359	18.972	9.264	−6.575	1.00	20.99		N
  ATOM	2262	C	LYS	G	359	18.561	16.282	−8.584	1.00	10.46		C
  ATOM	2263	O	LYS	G	359	19.145	16.533	−9.637	1.00	10.70		O
  ATOM	2264	N	VAL	G	360	18.526	17.128	−7.564	1.00	9.99		N
  ATOM	2265	CA	VAL	G	360	18.797	18.538	−7.763	1.00	9.84		C
  ATOM	2266	CB	VAL	G	360	17.573	19.270	−8.346	1.00	9.42		C
  ATOM	2267	CG1	VAL	G	360	16.360	19.095	−7.442	1.00	10.07		C
  ATOM	2268	CG2	VAL	G	360	17.886	20.740	−8.572	1.00	9.56		C
  ATOM	2269	C	VAL	G	360	19.259	19.211	−6.478	1.00	9.98		C
  ATOM	2270	O	VAL	G	360	18.707	18.970	−5.405	1.00	9.96		O
  ATOM	2271	N	GLN	G	361	20.372	19.931	−6.578	1.00	10.39		N
  ATOM	2272	CA	GLN	G	361	20.979	20.583	−5.427	1.00	11.53		C
  ATOM	2273	CB	GLN	G	361	22.220	19.809	−4.971	1.00	12.03		C
  ATOM	2274	CG	GLN	G	361	22.907	20.381	−3.737	1.00	16.44		C
  ATOM	2275	CD	GLN	G	361	23.241	19.314	−2.714	1.00	25.16		C
  ATOM	2276	OE1	GLN	G	361	24.398	18.921	−2.564	1.00	29.01		O
  ATOM	2277	NE2	GLN	G	361	22.220	18.812	−2.029	1.00	27.20		N
  ATOM	2278	C	GLN	G	361	21.373	22.005	−5.794	1.00	11.15		C
  ATOM	2279	O	GLN	G	361	22.354	22.221	−6.506	1.00	11.80		O
  ATOM	2280	N	SER	G	362	20.611	22.976	−5.308	1.00	10.90		N
  ATOM	2281	CA	SER	G	362	20.759	24.332	−5.798	1.00	10.30		C
  ATOM	2282	CB	SER	G	362	22.208	24.792	−5.625	1.00	10.47		C
  ATOM	2283	OG	SER	G	362	22.406	26.082	−6.179	1.00	11.17		O
  ATOM	2284	C	SER	G	362	20.385	24.348	−7.272	1.00	9.58		C
  ATOM	2285	O	SER	G	362	19.409	23.717	−7.677	1.00	9.48		O
  ATOM	2286	N	ASN	G	363	21.256	24.926	−8.089	1.00	9.12		N
  ATOM	2287	CA	ASN	G	363	21.023	24.985	−9.525	1.00	8.73		C
  ATOM	2288	CB	ASN	G	363	21.537	26.308	−10.085	1.00	9.01		C
  ATOM	2289	CG	ASN	G	363	23.018	26.497	−9.849	1.00	9.29		C
  ATOM	2290	OD1	ASN	G	363	23.681	25.636	−9.270	1.00	9.82		O
  ATOM	2291	ND2	ASN	G	363	23.555	27.615	−10.323	1.00	10.08		N
  ATOM	2292	C	ASN	G	363	21.701	23.822	−10.237	1.00	8.12		C
  ATOM	2293	O	ASN	G	363	21.961	23.881	−11.439	1.00	8.10		O
  ATOM	2294	N	ARG	G	364	22.103	22.828	−9.453	1.00	7.20		N
  ATOM	2295	CA	ARG	G	364	22.733	21.628	−9.984	1.00	6.82		C
  ATOM	2296	CB	ARG	G	364	23.843	21.154	−9.044	1.00	6.91		C
  ATOM	2297	CG	ARG	G	364	25.110	20.721	−9.754	1.00	7.92		C
  ATOM	2298	CD	ARG	G	364	25.588	21.797	−10.709	1.00	8.20		C
  ATOM	2299	NE	ARG	G	364	25.809	21.275	−12.053	1.00	8.70		N
  ATOM	2300	CZ	ARG	G	364	26.690	21.777	−12.910	1.00	8.88		C
  ATOM	2301	NH1	ARG	G	364	27.407	22.843	−12.578	1.00	8.57		N
  ATOM	2302	NH2	ARG	G	364	26.840	21.228	−14.107	1.00	10.59		N
  ATOM	2303	C	ARG	G	364	21.703	20.519	−10.166	1.00	6.58		C
  ATOM	2304	O	ARG	G	364	20.980	20.173	−9.233	1.00	6.65		O
  ATOM	2305	N	VAL	G	365	21.719	19.897	−11.341	1.00	6.64		N
  ATOM	2306	CA	VAL	G	365	20.802	18.805	−11.658	1.00	6.54		C
  ATOM	2307	CB	VAL	G	365	19.823	19.208	−12.782	1.00	5.95		C
  ATOM	2308	CG1	VAL	G	365	19.069	17.993	−13.302	1.00	5.48		C
  ATOM	2309	CG2	VAL	G	365	18.861	20.277	−12.291	1.00	6.22		C
  ATOM	2310	C	VAL	G	365	21.569	17.549	−12.089	1.00	7.35		C
  ATOM	2311	O	VAL	G	365	22.611	17.641	−12.740	1.00	8.33		O
  ATOM	2312	N	PHE	G	366	21.009	16.380	−11.781	1.00	7.37		N
  ATOM	2313	CA	PHE	G	366	21.654	15.097	−12.072	1.00	7.44		C
  ATOM	2314	CB	PHE	G	366	22.371	14.567	−10.822	1.00	7.30		C
  ATOM	2315	CG	PHE	G	366	23.464	15.468	−10.314	1.00	6.70		C
  ATOM	2316	CD1	PHE	G	366	23.160	16.576	−9.538	1.00	6.70		C
  ATOM	2317	CE1	PHE	G	366	24.162	17.406	−9.068	1.00	5.94		C
  ATOM	2318	CZ	PHE	G	366	25.487	17.053	−9.244	1.00	5.71		C
  ATOM	2319	CE2	PHE	G	366	25.804	15.897	−9.935	1.00	5.96		C
  ATOM	2320	CD2	PHE	G	366	24.793	15.094	−10.437	1.00	6.52		C
  ATOM	2321	C	PHE	G	366	20.626	14.059	−12.546	1.00	7.45		C
  ATOM	2322	O	PHE	G	366	19.770	13.635	−11.769	1.00	7.45		O
  ATOM	2323	N	CYS	G	367	20.783	13.569	−13.777	1.00	8.00		N
  ATOM	2324	CA	CYS	G	367	19.838	12.602	−14.369	1.00	8.90		C
  ATOM	2325	CB	CYS	G	367	18.879	13.313	−15.335	1.00	9.46		C
  ATOM	2326	SG	CYS	G	367	17.966	14.707	−14.624	1.00	10.79		S
  ATOM	2327	C	CYS	G	367	20.563	11.445	−15.089	1.00	9.09		C
  ATOM	2328	O	CYS	G	367	21.751	11.556	−15.396	1.00	9.24		O
  ATOM	2329	N	ASP	G	368	19.864	10.330	−15.323	1.00	9.54		N
  ATOM	2330	CA	ASP	G	368	20.480	9.110	−15.890	1.00	10.55		C
  ATOM	2331	CB	ASP	G	368	20.253	7.906	−14.962	1.00	10.53		C
  ATOM	2332	CG	ASP	G	368	21.043	6.674	−15.386	1.00	11.11		C
  ATOM	2333	OD1	ASP	G	368	21.241	6.475	−16.603	1.00	11.42		O
  ATOM	2334	OD2	ASP	G	368	21.441	5.892	−14.497	1.00	11.35		O
  ATOM	2335	C	ASP	G	368	19.947	8.774	−17.285	1.00	11.45		C
  ATOM	2336	O	ASP	G	368	19.035	7.958	−17.422	1.00	12.05		O
  ATOM	2337	N	THR	G	369	20.606	9.281	−18.321	1.00	12.41		N
  ATOM	2338	CA	THR	G	369	20.367	8.772	−19.666	1.00	13.00		C
  ATOM	2339	CB	THR	G	369	21.685	8.338	−20.361	1.00	12.69		C
  ATOM	2340	OG1	THR	G	369	22.580	9.456	−20.444	1.00	11.72		O
  ATOM	2341	CG2	THR	G	369	21.409	7.813	−21.765	1.00	13.33		C
  ATOM	2342	C	THR	G	369	19.406	7.585	−19.574	1.00	14.13		C
  ATOM	2343	O	THR	G	369	18.260	7.681	−20.008	1.00	14.72		O
  ATOM	2344	N	MET	G	370	19.790	6.577	−18.795	1.00	15.25		N
  ATOM	2345	CA	MET	G	370	19.286	5.221	−18.993	1.00	16.60		C
  ATOM	2346	CB	MET	G	370	19.132	4.486	−17.664	1.00	17.42		C
  ATOM	2347	CG	MET	G	370	19.948	3.204	−17.580	1.00	20.31		C
  ATOM	2348	SD	MET	G	370	19.542	1.991	−18.855	1.00	26.43		S
  ATOM	2349	CE	MET	G	370	20.369	2.694	−20.281	1.00	24.07		C
  ATOM	2350	C	MET	G	370	17.997	5.144	−19.811	1.00	16.54		C
  ATOM	2351	O	MET	G	370	17.975	4.516	−20.870	1.00	16.74		O
  ATOM	2352	N	ASN	G	371	16.923	5.762	−19.327	1.00	16.35		N
  ATOM	2353	CA	ASN	G	371	15.648	5.694	−20.042	1.00	16.07		C
  ATOM	2354	CB	ASN	G	371	14.554	5.050	−19.184	1.00	16.41		C
  ATOM	2355	CG	ASN	G	371	14.652	3.531	−19.153	1.00	16.71		C
  ATOM	2356	OD1	ASN	G	371	14.117	2.843	−20.025	1.00	15.75		O
  ATOM	2357	ND2	ASN	G	371	15.228	3.003	−18.080	1.00	17.76		N
  ATOM	2358	C	ASN	G	371	15.160	7.004	−20.661	1.00	15.55		C
  ATOM	2359	O	ASN	G	371	14.132	7.023	−21.334	1.00	15.84		O
  ATOM	2360	N	SER	G	372	16.006	8.030	−20.612	1.00	14.76		N
  ATOM	2361	CA	SER	G	372	15.784	9.270	−21.364	1.00	13.91		C
  ATOM	2362	CB	SER	G	372	17.101	10.025	−21.561	1.00	14.04		C
  ATOM	2363	OG	SER	G	372	17.984	9.303	−22.405	1.00	15.09		O
  ATOM	2364	C	SER	G	372	15.111	9.064	−22.717	1.00	13.07		C
  ATOM	2365	O	SER	G	372	15.417	8.111	−23.437	1.00	13.02		O
  ATOM	2366	N	LEU	G	373	14.347	10.072	−23.130	1.00	12.23		N
  ATOM	2367	CA	LEU	G	373	13.882	10.192	−24.508	1.00	11.45		C
  ATOM	2368	CB	LEU	G	373	12.358	10.365	−24.534	1.00	11.43		C
  ATOM	2369	CG	LEU	G	373	11.464	9.123	−24.683	1.00	11.04		C
  ATOM	2370	CD1	LEU	G	373	11.965	7.948	−23.852	1.00	11.76		C
  ATOM	2371	CD2	LEU	G	373	10.020	9.434	−24.330	1.00	10.49		C
  ATOM	2372	C	LEU	G	373	14.550	11.392	−25.176	1.00	11.17		C
  ATOM	2373	O	LEU	G	373	14.658	12.460	−24.574	1.00	11.27		O
  ATOM	2374	N	THR	G	374	15.011	11.208	−26.411	1.00	10.70		N
  ATOM	2375	CA	THR	G	374	15.791	12.235	−27.102	1.00	10.23		C
  ATOM	2376	CB	THR	G	374	16.998	11.634	−27.863	1.00	10.24		C
  ATOM	2377	OG1	THR	G	374	17.406	10.410	−27.239	1.00	11.25		O
  ATOM	2378	CG2	THR	G	374	18.168	12.612	−27.872	1.00	10.52		C
  ATOM	2379	C	THR	G	374	14.934	13.032	−28.079	1.00	9.54		C
  ATOM	2380	O	THR	G	374	14.316	12.468	−28.983	1.00	9.70		O
  ATOM	2381	N	LEU	G	375	14.965	14.352	−27.935	1.00	8.83		N
  ATOM	2382	CA	LEU	G	375	14.013	15.221	−28.611	1.00	7.83		C
  ATOM	2383	CB	LEU	G	375	12.949	15.719	−27.631	1.00	7.38		C
  ATOM	2384	CG	LEU	G	375	12.160	14.689	−26.824	1.00	5.06		C
  ATOM	2385	CD1	LEU	G	375	11.352	15.385	−25.741	1.00	2.41		C
  ATOM	2386	CD2	LEU	G	375	11.246	13.885	−27.734	1.00	4.31		C
  ATOM	2387	C	LEU	G	375	14.728	16.416	−29.222	1.00	7.79		C
  ATOM	2388	O	LEU	G	375	15.743	16.872	−28.696	1.00	7.92		O
  ATOM	2389	N	PRO	G	376	14.102	17.026	−30.234	1.00	7.51		N
  ATOM	2390	CA	PRO	G	376	14.606	18.224	−30.892	1.00	7.90		C
  ATOM	2391	CB	PRO	G	376	13.837	18.238	−32.211	1.00	7.90		C
  ATOM	2392	CG	PRO	G	376	12.558	17.556	−31.891	1.00	7.97		C
  ATOM	2393	CD	PRO	G	376	12.913	16.481	−30.912	1.00	7.40		C
  ATOM	2394	C	PRO	G	376	14.294	19.486	−30.095	1.00	8.35		C
  ATOM	2395	O	PRO	G	376	13.205	19.611	−29.533	1.00	8.71		O
  ATOM	2396	N	SER	G	377	15.206	20.451	−30.137	1.00	9.11		N
  ATOM	2397	CA	SER	G	377	14.990	21.743	−29.494	1.00	9.91		C
  ATOM	2398	CB	SER	G	377	16.155	22.691	−29.792	1.00	10.23		C
  ATOM	2399	OG	SER	G	377	17.300	21.973	−30.222	1.00	10.90		O
  ATOM	2400	C	SER	G	377	13.673	22.377	−29.937	1.00	10.14		C
  ATOM	2401	O	SER	G	377	13.295	23.444	−29.450	1.00	10.08		O
  ATOM	2402	N	GLU	G	378	13.011	21.749	−30.906	1.00	10.71		N
  ATOM	2403	CA	GLU	G	378	11.714	22.222	−31.382	1.00	11.40		C
  ATOM	2404	CB	GLU	G	378	11.357	21.569	−32.721	1.00	11.65		C
  ATOM	2405	CG	GLU	G	378	11.978	22.250	−33.933	1.00	13.46		C
  ATOM	2406	CD	GLU	G	378	13.490	22.160	−33.938	1.00	16.20		C
  ATOM	2407	OE1	GLU	G	378	14.046	21.522	−33.021	1.00	15.73		O
  ATOM	2408	OE2	GLU	G	378	14.121	22.732	−34.852	1.00	18.38		O
  ATOM	2409	C	GLU	G	378	10.623	21.944	−30.353	1.00	11.27		C
  ATOM	2410	O	GLU	G	378	9.561	22.565	−30.377	1.00	11.28		O
  ATOM	2411	N	VAL	G	379	10.909	21.031	−29.430	1.00	11.31		N
  ATOM	2412	CA	VAL	G	379	10.053	20.819	−28.269	1.00	11.59		C
  ATOM	2413	CB	VAL	G	379	10.737	19.926	−27.216	1.00	11.27		C
  ATOM	2414	CG1	VAL	G	379	10.100	20.131	−25.850	1.00	11.60		C
  ATOM	2415	CG2	VAL	G	379	10.667	18.465	−27.631	1.00	11.54		C
  ATOM	2416	C	VAL	G	379	9.665	22.144	−27.620	1.00	12.16		C
  ATOM	2417	O	VAL	G	379	8.541	22.307	−27.146	1.00	12.51		O
  ATOM	2418	N	ASN	G	380	10.587	23.100	−27.634	1.00	12.98		N
  ATOM	2419	CA	ASN	G	380	10.415	24.335	−26.878	1.00	14.00		C
  ATOM	2420	CB	ASN	G	380	11.703	25.156	−26.884	1.00	14.59		C
  ATOM	2421	CG	ASN	G	380	12.829	24.474	−26.138	1.00	17.09		C
  ATOM	2422	OD1	ASN	G	380	13.073	24.764	−24.966	1.00	20.41		O
  ATOM	2423	ND2	ASN	G	380	13.432	23.471	−26.767	1.00	18.86		N
  ATOM	2424	C	ASN	G	380	9.242	25.192	−27.349	1.00	13.96		C
  ATOM	2425	O	ASN	G	380	8.640	25.915	−26.555	1.00	14.38		O
  ATOM	2426	N	LEU	G	381	8.994	25.197	−28.655	1.00	13.61		N
  ATOM	2427	CA	LEU	G	381	7.918	26.006	−29.220	1.00	13.72		C
  ATOM	2428	CB	LEU	G	381	7.854	25.829	−30.737	1.00	13.79		C
  ATOM	2429	CG	LEU	G	381	9.183	25.514	−31.424	1.00	14.92		C
  ATOM	2430	CD1	LEU	G	381	8.969	25.231	−32.902	1.00	15.56		C
  ATOM	2431	CD2	LEU	G	381	10.171	26.655	−31.230	1.00	15.78		C
  ATOM	2432	C	LEU	G	381	6.590	25.603	−28.600	1.00	13.62		C
  ATOM	2433	O	LEU	G	381	5.600	26.331	−28.682	1.00	13.57		O
  ATOM	2434	N	CYS	G	382	6.590	24.440	−27.963	1.00	13.47		N
  ATOM	2435	CA	CYS	G	382	5.383	23.876	−27.392	1.00	13.57		C
  ATOM	2436	CB	CYS	G	382	5.572	22.380	−27.161	1.00	13.62		C
  ATOM	2437	SG	CYS	G	382	4.877	21.350	−28.457	1.00	15.64		S
  ATOM	2438	C	CYS	G	382	5.019	24.572	−26.085	1.00	13.33		C
  ATOM	2439	O	CYS	G	382	3.861	24.561	−25.669	1.00	13.57		O
  ATOM	2440	N	ASN	G	383	5.999	25.236	−25.480	1.00	13.21		N
  ATOM	2441	CA	ASN	G	383	5.736	26.114	−24.345	1.00	13.22		C
  ATOM	2442	CB	ASN	G	383	7.046	26.621	−23.742	1.00	13.18		C
  ATOM	2443	CG	ASN	G	383	7.979	25.498	−23.349	1.00	13.42		C
  ATOM	2444	OD1	ASN	G	383	7.560	24.505	−22.755	1.00	13.68		O
  ATOM	2445	ND2	ASN	G	383	9.255	25.648	−23.682	1.00	14.32		N
  ATOM	2446	C	ASN	G	383	4.872	27.298	−24.747	1.00	13.28		C
  ATOM	2447	O	ASN	G	383	4.229	27.925	−23.906	1.00	13.50		O
  ATOM	2448	N	VAL	G	384	5.000	27.699	−26.005	1.00	13.24		N
  ATOM	2449	CA	VAL	G	384	4.313	28.878	−26.496	1.00	13.29		C
  ATOM	2450	CB	VAL	G	384	5.234	29.751	−27.370	1.00	13.28		C
  ATOM	2451	CG1	VAL	G	384	4.414	30.627	−28.302	1.00	13.73		C
  ATOM	2452	CG2	VAL	G	384	6.145	30.599	−26.495	1.00	12.76		C
  ATOM	2453	C	VAL	G	384	3.045	28.514	−27.261	1.00	13.57		C
  ATOM	2454	O	VAL	G	384	2.050	29.233	−27.188	1.00	13.31		O
  ATOM	2455	N	ASP	G	385	3.056	27.383	−27.960	1.00	14.07		N
  ATOM	2456	CA	ASP	G	385	1.999	27.121	−28.932	1.00	14.61		C
  ATOM	2457	CB	ASP	G	385	2.452	27.379	−30.366	1.00	14.71		C
  ATOM	2458	CG	ASP	G	385	1.436	28.182	−31.154	1.00	16.69		C
  ATOM	2459	OD1	ASP	G	385	0.270	28.259	−30.713	1.00	18.63		O
  ATOM	2460	OD2	ASP	G	385	1.807	28.759	−32.197	1.00	19.10		O
  ATOM	2461	C	ASP	G	385	1.170	25.841	−28.816	1.00	14.63		C
  ATOM	2462	O	ASP	G	385	−0.043	25.880	−29.017	1.00	14.34		O
  ATOM	2463	N	ILE	G	386	1.820	24.697	−28.624	1.00	14.54		N
  ATOM	2464	CA	ILE	G	386	1.116	23.413	−28.688	1.00	14.46		C
  ATOM	2465	CB	ILE	G	386	−0.230	23.466	−27.928	1.00	13.83		C
  ATOM	2466	CG1	ILE	G	386	−0.004	23.458	−26.415	1.00	13.44		C
  ATOM	2467	CD1	ILE	G	386	−1.184	23.970	−25.612	1.00	12.39		C
  ATOM	2468	CG2	ILE	G	386	−1.119	22.301	−28.341	1.00	13.51		C
  ATOM	2469	C	ILE	G	386	0.791	23.079	−30.134	1.00	14.73		C
  ATOM	2470	O	ILE	G	386	1.282	22.092	−30.683	1.00	14.68		O
  ATOM	2471	N	PHE	G	387	−0.191	23.797	−30.667	1.00	14.71		N
  ATOM	2472	CA	PHE	G	387	−0.462	23.794	−32.092	1.00	14.78		C
  ATOM	2473	CB	PHE	G	387	−1.889	24.254	−32.366	1.00	14.77		C
  ATOM	2474	CG	PHE	G	387	−2.906	23.607	−31.479	1.00	14.75		C
  ATOM	2475	CD1	PHE	G	387	−3.418	24.287	−30.390	1.00	15.03		C
  ATOM	2476	CE1	PHE	G	387	−4.333	23.684	−29.549	1.00	14.62		C
  ATOM	2477	CZ	PHE	G	387	−4.683	22.364	−29.747	1.00	14.55		C
  ATOM	2478	CE2	PHE	G	387	−4.113	21.651	−30.780	1.00	14.68		C
  ATOM	2479	CD2	PHE	G	387	−3.206	22.265	−31.621	1.00	14.61		C
  ATOM	2480	C	PHE	G	387	0.526	24.670	−32.837	1.00	14.91		C
  ATOM	2481	O	PHE	G	387	0.658	25.862	−32.559	1.00	14.86		O
  ATOM	2482	N	ASN	G	388	1.361	24.007	−33.621	1.00	15.11		N
  ATOM	2483	CA	ASN	G	388	2.352	24.663	−34.443	1.00	15.38		C
  ATOM	2484	CB	ASN	G	388	3.362	25.405	−33.570	1.00	14.86		C
  ATOM	2485	CG	ASN	G	388	4.097	24.480	−32.625	1.00	14.86		C
  ATOM	2486	OD1	ASN	G	388	5.078	23.840	−33.004	1.00	12.80		O
  ATOM	2487	ND2	ASN	G	388	3.575	24.338	−31.413	1.00	15.97		N
  ATOM	2488	C	ASN	G	388	3.057	23.576	−35.229	1.00	16.11		C
  ATOM	2489	O	ASN	G	388	3.416	22.537	−34.670	1.00	15.92		O
  ATOM	2490	N	PRO	G	389	3.071	23.722	−36.557	1.00	16.99		N
  ATOM	2491	CA	PRO	G	389	4.005	22.905	−37.315	1.00	17.40		C
  ATOM	2492	CB	PRO	G	389	4.169	23.689	−38.618	1.00	17.72		C
  ATOM	2493	CG	PRO	G	389	3.905	25.099	−38.236	1.00	17.47		C
  ATOM	2494	CD	PRO	G	389	2.825	25.023	−37.203	1.00	17.05		C
  ATOM	2495	C	PRO	G	389	5.338	22.827	−36.583	1.00	17.86		C
  ATOM	2496	O	PRO	G	389	5.638	23.687	−35.755	1.00	18.45		O
  ATOM	2497	N	LYS	G	390	6.139	21.817	−36.902	1.00	17.97		N
  ATOM	2498	CA	LYS	G	390	7.443	21.658	−36.273	1.00	18.06		C
  ATOM	2499	CB	LYS	G	390	7.947	22.997	−35.730	1.00	17.92		C
  ATOM	2500	CG	LYS	G	390	8.466	23.945	−36.798	1.00	18.58		C
  ATOM	2501	CD	LYS	G	390	9.962	23.777	−37.006	1.00	20.61		C
  ATOM	2502	CE	LYS	G	390	10.562	24.985	−37.707	1.00	21.48		C
  ATOM	2503	NZ	LYS	G	390	10.191	25.032	−39.148	1.00	23.16		N
  ATOM	2504	C	LYS	G	390	7.398	20.623	−35.156	1.00	18.01		C
  ATOM	2505	O	LYS	G	390	8.177	19.670	−35.152	1.00	18.43		O
  ATOM	2506	N	TYR	G	391	6.481	20.805	−34.213	1.00	17.68		N
  ATOM	2507	CA	TYR	G	391	6.234	19.780	−33.211	1.00	17.33		C
  ATOM	2508	CB	TYR	G	391	6.862	20.158	−31.872	1.00	17.42		C
  ATOM	2509	CG	TYR	G	391	7.485	18.979	−31.173	1.00	17.27		C
  ATOM	2510	CD1	TYR	G	391	8.188	18.028	−31.898	1.00	17.29		C
  ATOM	2511	CE1	TYR	G	391	8.672	16.885	−31.297	1.00	17.32		C
  ATOM	2512	CZ	TYR	G	391	8.408	16.653	−29.965	1.00	16.51		C
  ATOM	2513	OH	TYR	G	391	8.940	15.541	−29.354	1.00	16.65		O
  ATOM	2514	CE2	TYR	G	391	7.656	17.552	−29.237	1.00	16.52		C
  ATOM	2515	CD2	TYR	G	391	7.167	18.687	−29.853	1.00	17.24		C
  ATOM	2516	C	TYR	G	391	4.757	19.471	−33.034	1.00	17.43		C
  ATOM	2517	O	TYR	G	391	3.984	20.332	−32.614	1.00	17.70		O
  ATOM	2518	N	ASP	G	392	4.398	18.202	−33.196	1.00	17.56		N
  ATOM	2519	CA	ASP	G	392	3.191	17.693	−32.565	1.00	17.69		C
  ATOM	2520	CB	ASP	G	392	2.610	16.498	−33.322	1.00	17.89		C
  ATOM	2521	CG	ASP	G	392	3.494	16.038	−34.456	1.00	18.86		C
  ATOM	2522	OD1	ASP	G	392	4.636	15.613	−34.185	1.00	20.34		O
  ATOM	2523	OD2	ASP	G	392	3.008	15.998	−35.604	1.00	18.51		O
  ATOM	2524	C	ASP	G	392	3.428	17.344	−31.107	1.00	17.11		C
  ATOM	2525	O	ASP	G	392	4.495	16.860	−30.731	1.00	17.04		O
  ATOM	2526	N	CYS	G	393	2.452	17.684	−30.280	1.00	16.33		N
  ATOM	2527	CA	CYS	G	393	2.723	18.199	−28.957	1.00	16.17		C
  ATOM	2528	CB	CYS	G	393	2.419	19.693	−28.910	1.00	16.11		C
  ATOM	2529	SG	CYS	G	393	3.237	20.556	−27.570	1.00	20.23		S
  ATOM	2530	C	CYS	G	393	1.812	17.471	−27.995	1.00	15.37		C
  ATOM	2531	O	CYS	G	393	0.592	17.525	−28.139	1.00	15.15		O
  ATOM	2532	N	LYS	G	394	2.399	16.618	−27.168	1.00	14.91		N
  ATOM	2533	CA	LYS	G	394	1.608	15.678	−26.398	1.00	14.50		C
  ATOM	2534	CB	LYS	G	394	2.495	14.607	−25.771	1.00	14.60		C
  ATOM	2535	CG	LYS	G	394	3.531	14.052	−26.730	1.00	16.44		C
  ATOM	2536	CD	LYS	G	394	4.034	12.699	−26.272	1.00	20.45		C
  ATOM	2537	CE	LYS	G	394	4.868	12.823	−25.009	1.00	23.05		C
  ATOM	2538	NZ	LYS	G	394	4.057	13.264	−23.841	1.00	24.13		N
  ATOM	2539	C	LYS	G	394	0.767	16.388	−25.344	1.00	14.00		C
  ATOM	2540	O	LYS	G	394	1.249	17.268	−24.630	1.00	14.14		O
  ATOM	2541	N	ILE	G	395	−0.486	15.955	−25.236	1.00	13.28		N
  ATOM	2542	CA	ILE	G	395	−1.587	16.768	−24.725	1.00	12.89		C
  ATOM	2543	CB	ILE	G	395	−2.234	17.626	−25.843	1.00	12.75		C
  ATOM	2544	CG1	ILE	G	395	−1.418	18.897	−26.097	1.00	13.58		C
  ATOM	2545	CD1	ILE	G	395	−1.635	19.507	−27.466	1.00	15.33		C
  ATOM	2546	CG2	ILE	G	395	−3.669	17.980	−25.477	1.00	12.16		C
  ATOM	2547	C	ILE	G	395	−2.631	15.761	−24.284	1.00	13.15		C
  ATOM	2548	O	ILE	G	395	−2.826	14.746	−24.951	1.00	13.45		O
  ATOM	2549	N	MET	G	396	−3.440	16.127	−23.303	1.00	13.06		N
  ATOM	2550	CA	MET	G	396	−4.668	15.392	−23.085	1.00	13.00		C
  ATOM	2551	CB	MET	G	396	−4.579	14.539	−21.824	1.00	13.34		C
  ATOM	2552	CG	MET	G	396	−5.208	15.167	−20.600	1.00	14.30		C
  ATOM	2553	SD	MET	G	396	−5.006	14.087	−19.179	1.00	18.50		S
  ATOM	2554	CE	MET	G	396	−3.465	13.282	−19.611	1.00	17.80		C
  ATOM	2555	C	MET	G	396	−5.889	16.288	−23.050	1.00	12.96		C
  ATOM	2556	O	MET	G	396	−5.811	17.453	−22.663	1.00	13.04		O
  ATOM	2557	N	THR	G	397	−7.037	15.686	−23.336	1.00	12.78		N
  ATOM	2558	CA	THR	G	397	−8.200	16.415	−23.815	1.00	12.51		C
  ATOM	2559	CB	THR	G	397	−8.653	15.898	−25.193	1.00	12.39		C
  ATOM	2560	OG1	THR	G	397	−7.837	16.481	−26.216	1.00	12.50		O
  ATOM	2561	CG2	THR	G	397	−10.114	16.250	−25.447	1.00	12.55		C
  ATOM	2562	C	THR	G	397	−9.343	16.223	−22.834	1.00	12.58		C
  ATOM	2563	O	THR	G	397	−9.563	15.117	−22.340	1.00	12.88		O
  ATOM	2564	N	SER	G	398	−10.157	17.255	−22.663	1.00	12.55		N
  ATOM	2565	CA	SER	G	398	−11.452	17.049	−22.049	1.00	12.76		C
  ATOM	2566	CB	SER	G	398	−11.323	16.949	−20.527	1.00	12.52		C
  ATOM	2567	OG	SER	G	398	−12.592	16.781	−19.919	1.00	12.72		O
  ATOM	2568	C	SER	G	398	−12.478	18.103	−22.410	1.00	12.99		C
  ATOM	2569	O	SER	G	398	−12.269	18.917	−23.311	1.00	13.13		O
  ATOM	2570	N	LYS	G	399	−13.435	18.245	−21.504	1.00	13.01		N
  ATOM	2571	CA	LYS	G	399	−14.399	19.325	−21.544	1.00	13.29		C
  ATOM	2572	CB	LYS	G	399	−15.777	18.777	−21.908	1.00	13.79		C
  ATOM	2573	CG	LYS	G	399	−16.044	18.714	−23.399	1.00	14.34		C
  ATOM	2574	CD	LYS	G	399	−16.965	19.840	−23.833	1.00	16.43		C
  ATOM	2575	CE	LYS	G	399	−17.285	19.750	−25.315	1.00	17.37		C
  ATOM	2576	NZ	LYS	G	399	−17.904	21.003	−25.828	1.00	16.62		N
  ATOM	2577	C	LYS	G	399	−14.460	19.996	−20.179	1.00	13.09		C
  ATOM	2578	O	LYS	G	399	−14.619	21.213	−20.084	1.00	12.87		O
  ATOM	2579	N	THR	G	400	−14.348	19.198	−19.123	1.00	13.04		N
  ATOM	2580	CA	THR	G	400	−14.535	19.715	−17.776	1.00	13.38		C
  ATOM	2581	CB	THR	G	400	−15.257	18.709	−16.861	1.00	13.74		C
  ATOM	2582	OG1	THR	G	400	−15.856	17.678	−17.655	1.00	14.38		O
  ATOM	2583	CG2	THR	G	400	−16.337	19.409	−16.051	1.00	14.32		C
  ATOM	2584	C	THR	G	400	−13.226	20.134	−17.120	1.00	13.20		C
  ATOM	2585	O	THR	G	400	−12.169	19.594	−17.445	1.00	13.12		O
  ATOM	2586	N	ASP	G	401	−13.378	20.770	−15.963	1.00	12.97		N
  ATOM	2587	CA	ASP	G	401	−12.358	21.654	−15.396	1.00	12.50		C
  ATOM	2588	CB	ASP	G	401	−13.014	22.766	−14.590	1.00	12.73		C
  ATOM	2589	CG	ASP	G	401	−12.765	24.122	−15.183	1.00	13.98		C
  ATOM	2590	OD1	ASP	G	401	−13.073	24.301	−16.380	1.00	16.55		O
  ATOM	2591	OD2	ASP	G	401	−12.168	24.973	−14.492	1.00	14.80		O
  ATOM	2592	C	ASP	G	401	−11.269	21.029	−14.529	1.00	12.13		C
  ATOM	2593	O	ASP	G	401	−11.547	20.130	−13.729	1.00	12.31		O
  ATOM	2594	N	VAL	G	402	−10.200	21.822	−14.390	1.00	11.49		N
  ATOM	2595	CA	VAL	G	402	−9.667	22.261	−13.080	1.00	10.74		C
  ATOM	2596	CB	VAL	G	402	−8.369	21.519	−12.744	1.00	10.60		C
  ATOM	2597	CG1	VAL	G	402	−7.449	22.413	−11.914	1.00	11.26		C
  ATOM	2598	CG2	VAL	G	402	−8.672	20.211	−12.019	1.00	10.99		C
  ATOM	2599	C	VAL	G	402	−9.360	23.769	−12.883	1.00	10.24		C
  ATOM	2600	O	VAL	G	402	−9.387	24.539	−13.845	1.00	10.30		O
  ATOM	2601	N	SER	G	403	−8.762	24.081	−11.719	1.00	9.76		N
  ATOM	2602	CA	SER	G	403	−8.493	25.474	−11.271	1.00	9.18		C
  ATOM	2603	CB	SER	G	403	−9.790	26.197	−10.893	1.00	9.41		C
  ATOM	2604	OG	SER	G	403	−10.714	25.319	−10.274	1.00	10.82		O
  ATOM	2605	C	SER	G	403	−7.394	25.745	−10.199	1.00	8.51		C
  ATOM	2606	O	SER	G	403	−7.465	25.236	−9.076	1.00	8.30		O
  ATOM	2607	N	SER	G	404	−6.524	26.720	−10.502	1.00	8.35		N
  ATOM	2608	CA	SER	G	404	−5.785	27.535	−9.507	1.00	8.18		C
  ATOM	2609	CB	SER	G	404	−4.851	26.657	−8.669	1.00	8.18		C
  ATOM	2610	OG	SER	G	404	−3.507	26.782	−9.100	1.00	8.83		O
  ATOM	2611	C	SER	G	404	−4.979	28.665	−10.187	1.00	7.62		C
  ATOM	2612	O	SER	G	404	−5.183	28.942	−11.369	1.00	7.57		O
  ATOM	2613	N	SER	G	405	−4.041	29.282	−9.462	1.00	7.08		N
  ATOM	2614	CA	SER	G	405	−3.258	30.409	−10.003	1.00	6.53		C
  ATOM	2615	CB	SER	G	405	−3.844	31.752	−9.555	1.00	6.42		C
  ATOM	2616	OG	SER	G	405	−2.883	32.790	−9.662	1.00	5.66		O
  ATOM	2617	C	SER	G	405	−1.756	30.364	−9.693	1.00	6.28		C
  ATOM	2618	O	SER	G	405	−1.338	29.830	−8.666	1.00	5.98		O
  ATOM	2619	N	VAL	G	406	−0.980	31.079	−10.506	1.00	6.22		N
  ATOM	2620	CA	VAL	G	406	0.479	31.053	−10.436	1.00	6.50		C
  ATOM	2621	CB	VAL	G	406	1.068	30.055	−11.453	1.00	6.45		C
  ATOM	2622	CG1	VAL	G	406	2.518	29.743	−11.116	1.00	7.66		C
  ATOM	2623	CG2	VAL	G	406	0.236	28.783	−11.495	1.00	7.38		C
  ATOM	2624	C	VAL	G	406	1.029	32.438	−10.760	1.00	6.24		C
  ATOM	2625	O	VAL	G	406	0.763	32.981	−11.832	1.00	6.14		O
  ATOM	2626	N	ILE	G	407	1.803	33.001	−9.840	1.00	6.32		N
  ATOM	2627	CA	ILE	G	407	2.315	34.354	−10.014	1.00	6.60		C
  ATOM	2628	CB	ILE	G	407	2.445	35.097	−8.674	1.00	6.27		C
  ATOM	2629	CG1	ILE	G	407	1.070	35.564	−8.194	1.00	6.19		C
  ATOM	2630	CD1	ILE	G	407	1.086	36.200	−6.824	1.00	8.34		C
  ATOM	2631	CG2	ILE	G	407	3.391	36.282	−8.813	1.00	6.42		C
  ATOM	2632	C	ILE	G	407	3.657	34.361	−10.728	1.00	7.20		C
  ATOM	2633	O	ILE	G	407	4.576	33.631	−10.356	1.00	7.42		O
  ATOM	2634	N	THR	G	408	3.797	35.273	−11.682	1.00	7.57		N
  ATOM	2635	CA	THR	G	408	4.983	35.324	−12.517	1.00	8.19		C
  ATOM	2636	CB	THR	G	408	4.622	35.305	−14.011	1.00	8.15		C
  ATOM	2637	OG1	THR	G	408	3.785	36.426	−14.318	1.00	8.88		O
  ATOM	2638	CG2	THR	G	408	3.891	34.020	−14.364	1.00	7.93		C
  ATOM	2639	C	THR	G	408	5.804	36.569	−12.225	1.00	8.55		C
  ATOM	2640	O	THR	G	408	5.418	37.408	−11.410	1.00	9.07		O
  ATOM	2641	N	SER	G	409	6.918	36.698	−12.935	1.00	8.70		N
  ATOM	2642	CA	SER	G	409	7.843	37.799	−12.723	1.00	9.20		C
  ATOM	2643	CB	SER	G	409	9.067	37.643	−13.628	1.00	9.72		C
  ATOM	2644	OG	SER	G	409	9.571	36.320	−13.581	1.00	10.75		O
  ATOM	2645	C	SER	G	409	7.153	39.125	−13.007	1.00	9.01		C
  ATOM	2646	O	SER	G	409	7.433	40.135	−12.359	1.00	9.02		O
  ATOM	2647	N	LEU	G	410	6.259	39.118	−13.990	1.00	8.91		N
  ATOM	2648	CA	LEU	G	410	5.790	40.352	−14.604	1.00	9.29		C
  ATOM	2649	CB	LEU	G	410	6.438	40.546	−15.976	1.00	9.61		C
  ATOM	2650	CG	LEU	G	410	7.245	41.834	−16.150	1.00	9.70		C
  ATOM	2651	CD1	LEU	G	410	8.433	41.858	−15.200	1.00	11.11		C
  ATOM	2652	CD2	LEU	G	410	7.705	41.994	−17.591	1.00	9.16		C
  ATOM	2653	C	LEU	G	410	4.272	40.351	−14.729	1.00	9.12		C
  ATOM	2654	O	LEU	G	410	3.683	41.248	−15.332	1.00	9.08		O
  ATOM	2655	N	GLY	G	411	3.646	39.332	−14.154	1.00	9.03		N
  ATOM	2656	CA	GLY	G	411	2.203	39.315	−13.982	1.00	8.44		C
  ATOM	2657	C	GLY	G	411	1.765	38.048	−13.284	1.00	7.91		C
  ATOM	2658	O	GLY	G	411	2.435	37.568	−12.369	1.00	7.85		O
  ATOM	2659	N	ALA	G	412	0.674	37.465	−13.763	1.00	7.30		N
  ATOM	2660	CA	ALA	G	412	0.129	36.264	−13.153	1.00	6.92		C
  ATOM	2661	CB	ALA	G	412	−0.742	36.623	−11.960	1.00	6.90		C
  ATOM	2662	C	ALA	G	412	−0.661	35.453	−14.166	1.00	6.99		C
  ATOM	2663	O	ALA	G	412	−1.257	36.002	−15.093	1.00	6.94		O
  ATOM	2664	N	ILE	G	413	−0.621	34.137	−14.006	1.00	7.29		N
  ATOM	2665	CA	ILE	G	413	−1.478	33.244	−14.766	1.00	7.49		C
  ATOM	2666	CB	ILE	G	413	−0.711	31.990	−15.201	1.00	7.24		C
  ATOM	2667	CG1	ILE	G	413	0.314	32.350	−16.278	1.00	7.18		C
  ATOM	2668	CD1	ILE	G	413	0.927	31.150	−16.973	1.00	7.70		C
  ATOM	2669	CG2	ILE	G	413	−1.674	30.916	−15.688	1.00	7.70		C
  ATOM	2670	C	ILE	G	413	−2.657	32.822	−13.908	1.00	7.94		C
  ATOM	2671	O	ILE	G	413	−2.544	32.749	−12.685	1.00	8.39		O
  ATOM	2672	N	VAL	G	414	−3.782	32.521	−14.544	1.00	8.22		N
  ATOM	2673	CA	VAL	G	414	−4.909	31.961	−13.816	1.00	8.77		C
  ATOM	2674	CB	VAL	G	414	−5.865	33.050	−13.296	1.00	8.57		C
  ATOM	2675	CG1	VAL	G	414	−6.133	34.085	−14.376	1.00	9.12		C
  ATOM	2676	CG2	VAL	G	414	−7.162	32.427	−12.803	1.00	8.90		C
  ATOM	2677	C	VAL	G	414	−5.674	30.901	−14.594	1.00	8.92		C
  ATOM	2678	O	VAL	G	414	−6.114	31.129	−15.722	1.00	9.00		O
  ATOM	2679	N	SER	G	415	−5.750	29.714	−14.004	1.00	8.97		N
  ATOM	2680	CA	SER	G	415	−6.472	28.598	−14.592	1.00	9.02		C
  ATOM	2681	CB	SER	G	415	−5.625	27.328	−14.520	1.00	8.98		C
  ATOM	2682	OG	SER	G	415	−4.353	27.532	−15.108	1.00	9.54		O
  ATOM	2683	C	SER	G	415	−7.791	28.390	−13.864	1.00	9.36		C
  ATOM	2684	O	SER	G	415	−7.818	27.884	−12.742	1.00	9.61		O
  ATOM	2685	N	CYS	G	416	−8.854	28.950	−14.430	1.00	9.57		N
  ATOM	2686	CA	CYS	G	416	−10.175	28.857	−13.831	1.00	9.61		C
  ATOM	2687	CB	CYS	G	416	−10.895	30.201	−13.912	1.00	9.62		C
  ATOM	2688	SG	CYS	G	416	−12.025	30.497	−12.543	1.00	11.33		S
  ATOM	2689	C	CYS	G	416	−11.000	27.796	−14.534	1.00	9.61		C
  ATOM	2690	O	CYS	G	416	−11.361	27.950	−15.700	1.00	9.80		O
  ATOM	2691	N	TYR	G	417	−11.298	26.717	−13.821	1.00	9.48		N
  ATOM	2692	CA	TYR	G	417	−11.930	25.566	−14.438	1.00	9.28		C
  ATOM	2693	CB	TYR	G	417	−10.888	24.501	−14.782	1.00	9.17		C
  ATOM	2694	CG	TYR	G	417	−10.011	24.860	−15.962	1.00	8.71		C
  ATOM	2695	CD1	TYR	G	417	−8.661	24.543	−15.968	1.00	8.54		C
  ATOM	2696	CE1	TYR	G	417	−7.857	24.869	−17.043	1.00	9.56		C
  ATOM	2697	CZ	TYR	G	417	−8.407	25.480	−18.149	1.00	9.83		C
  ATOM	2698	OH	TYR	G	417	−7.602	25.828	−19.207	1.00	10.51		O
  ATOM	2699	CE2	TYR	G	417	−9.738	25.830	−18.159	1.00	9.36		C
  ATOM	2700	CD2	TYR	G	417	−10.532	25.522	−17.068	1.00	8.95		C
  ATOM	2701	C	TYR	G	417	−13.034	24.978	−13.566	1.00	9.35		C
  ATOM	2702	O	TYR	G	417	−13.171	25.332	−12.395	1.00	9.11		O
  ATOM	2703	N	GLY	G	418	−13.848	24.115	−14.165	1.00	9.71		N
  ATOM	2704	CA	GLY	G	418	−14.993	23.534	−13.481	1.00	9.95		C
  ATOM	2705	C	GLY	G	418	−15.925	24.594	−12.936	1.00	10.09		C
  ATOM	2706	O	GLY	G	418	−16.170	25.611	−13.585	1.00	10.17		O
  ATOM	2707	N	LYS	G	419	−16.323	24.426	−11.681	1.00	10.17		N
  ATOM	2708	CA	LYS	G	419	−17.328	25.289	−11.075	1.00	10.50		C
  ATOM	2709	CB	LYS	G	419	−18.123	24.523	−10.015	1.00	11.09		C
  ATOM	2710	CG	LYS	G	419	−19.389	23.867	−10.538	1.00	12.94		C
  ATOM	2711	CD	LYS	G	419	−20.304	23.450	−9.397	1.00	15.52		C
  ATOM	2712	CE	LYS	G	419	−21.702	23.127	−9.899	1.00	17.07		C
  ATOM	2713	NZ	LYS	G	419	−21.688	22.058	−10.936	1.00	19.30		N
  ATOM	2714	C	LYS	G	419	−16.737	26.560	−10.464	1.00	10.23		C
  ATOM	2715	O	LYS	G	419	−17.451	27.325	−9.817	1.00	10.58		O
  ATOM	2716	N	THR	G	420	−15.429	26.755	−10.607	1.00	10.10		N
  ATOM	2717	CA	THR	G	420	−14.730	27.754	−9.801	1.00	9.74		C
  ATOM	2718	CB	THR	G	420	−13.232	27.432	−9.651	1.00	9.28		C
  ATOM	2719	OG1	THR	G	420	−12.992	26.073	−10.034	1.00	9.21		O
  ATOM	2720	CG2	THR	G	420	−12.788	27.635	−8.209	1.00	9.03		C
  ATOM	2721	C	THR	G	420	−14.900	29.178	−10.329	1.00	9.95		C
  ATOM	2722	O	THR	G	420	−15.143	29.387	−11.518	1.00	10.35		O
  ATOM	2723	N	LYS	G	421	−14.816	30.149	−9.424	1.00	10.07		N
  ATOM	2724	CA	LYS	G	421	−14.950	31.559	−9.780	1.00	10.21		C
  ATOM	2725	CB	LYS	G	421	−15.973	32.239	−8.867	1.00	10.30		C
  ATOM	2726	CG	LYS	G	421	−17.368	32.341	−9.457	1.00	12.43		C
  ATOM	2727	CD	LYS	G	421	−18.345	32.931	−8.452	1.00	15.12		C
  ATOM	2728	CE	LYS	G	421	−19.766	32.470	−8.727	1.00	15.21		C
  ATOM	2729	NZ	LYS	G	421	−20.617	32.544	−7.508	1.00	15.98		N
  ATOM	2730	C	LYS	G	421	−13.608	32.271	−9.658	1.00	10.09		C
  ATOM	2731	O	LYS	G	421	−12.911	32.125	−8.653	1.00	10.36		O
  ATOM	2732	N	CYS	G	422	−13.271	33.085	−10.653	1.00	9.81		N
  ATOM	2733	CA	CYS	G	422	−12.006	33.808	−10.631	1.00	9.56		C
  ATOM	2734	CB	CYS	G	422	−10.953	33.092	−11.475	1.00	9.72		C
  ATOM	2735	SG	CYS	G	422	−10.831	31.329	−11.131	1.00	11.42		S
  ATOM	2736	C	CYS	G	422	−12.126	35.268	−11.044	1.00	9.18		C
  ATOM	2737	O	CYS	G	422	−12.927	35.624	−11.909	1.00	9.27		O
  ATOM	2738	N	THR	G	423	−11.232	36.084	−10.497	1.00	8.93		N
  ATOM	2739	CA	THR	G	423	−11.422	37.525	−10.427	1.00	8.64		C
  ATOM	2740	CB	THR	G	423	−12.062	37.938	−9.088	1.00	8.32		C
  ATOM	2741	OG1	THR	G	423	−13.201	37.111	−8.821	1.00	7.97		O
  ATOM	2742	CG2	THR	G	423	−12.494	39.396	−9.130	1.00	8.36		C
  ATOM	2743	C	THR	G	423	−10.059	38.190	−10.513	1.00	8.86		C
  ATOM	2744	O	THR	G	423	−9.183	37.928	−9.688	1.00	9.26		O
  ATOM	2745	N	ALA	G	424	−9.913	39.124	−11.444	1.00	8.74		N
  ATOM	2746	CA	ALA	G	424	−8.792	40.052	−11.408	1.00	8.79		C
  ATOM	2747	CB	ALA	G	424	−8.164	40.180	−12.786	1.00	8.94		C
  ATOM	2748	C	ALA	G	424	−9.240	41.414	−10.894	1.00	8.84		C
  ATOM	2749	O	ALA	G	424	−10.084	42.070	−11.504	1.00	9.24		O
  ATOM	2750	N	SER	G	425	−8.669	41.836	−9.771	1.00	8.81		N
  ATOM	2751	CA	SER	G	425	−9.007	43.124	−9.180	1.00	8.85		C
  ATOM	2752	CB	SER	G	425	−9.483	42.942	−7.737	1.00	8.94		C
  ATOM	2753	OG	SER	G	425	−9.918	41.613	−7.507	1.00	7.69		O
  ATOM	2754	C	SER	G	425	−7.815	44.072	−9.222	1.00	9.01		C
  ATOM	2755	O	SER	G	425	−6.669	43.651	−9.059	1.00	8.63		O
  ATOM	2756	N	ASN	G	426	−8.089	45.354	−9.441	1.00	9.54		N
  ATOM	2757	CA	ASN	G	426	−7.033	46.328	−9.686	1.00	10.19		C
  ATOM	2758	CB	ASN	G	426	−7.537	47.462	−10.583	1.00	9.77		C
  ATOM	2759	CG	ASN	G	426	−8.273	48.540	−9.808	1.00	9.43		C
  ATOM	2760	OD1	ASN	G	426	−8.253	48.561	−8.578	1.00	9.01		O
  ATOM	2761	ND2	ASN	G	426	−8.938	49.436	−10.528	1.00	9.01		N
  ATOM	2762	C	ASN	G	426	−6.434	46.891	−8.400	1.00	11.16		C
  ATOM	2763	O	ASN	G	426	−6.629	46.340	−7.316	1.00	11.06		O
  ATOM	2764	N	LYS	G	427	−5.658	47.961	−8.543	1.00	12.38		N
  ATOM	2765	CA	LYS	G	427	−5.016	48.627	−7.413	1.00	13.52		C
  ATOM	2766	CB	LYS	G	427	−4.455	49.981	−7.851	1.00	14.00		C
  ATOM	2767	CG	LYS	G	427	−2.987	49.956	−8.233	1.00	16.18		C
  ATOM	2768	CD	LYS	G	427	−2.434	51.366	−8.365	1.00	18.24		C
  ATOM	2769	CE	LYS	G	427	−0.955	51.413	−8.022	1.00	19.72		C
  ATOM	2770	NZ	LYS	G	427	−0.707	51.116	−6.584	1.00	21.43		N
  ATOM	2771	C	LYS	G	427	−5.976	48.829	−6.245	1.00	13.71		C
  ATOM	2772	O	LYS	G	427	−5.630	48.562	−5.093	1.00	13.63		O
  ATOM	2773	N	ASN	G	428	−7.119	49.443	−6.535	1.00	14.28		N
  ATOM	2774	CA	ASN	G	428	−8.080	49.830	−5.505	1.00	14.60		C
  ATOM	2775	CB	ASN	G	428	−9.009	50.934	−6.020	1.00	14.57		C
  ATOM	2776	CG	ASN	G	428	−8.353	51.808	−7.071	1.00	13.24		C
  ATOM	2777	OD1	ASN	G	428	−7.314	52.420	−6.823	1.00	9.74		O
  ATOM	2778	ND2	ASN	G	428	−9.009	51.946	−8.217	1.00	12.83		N
  ATOM	2779	C	ASN	G	428	−8.914	48.658	−4.994	1.00	14.83		C
  ATOM	2780	O	ASN	G	428	−9.645	48.793	−4.013	1.00	15.25		O
  ATOM	2781	N	ARG	G	429	−8.920	47.564	−5.750	1.00	14.78		N
  ATOM	2782	CA	ARG	G	429	−9.725	46.395	−5.407	1.00	14.74		C
  ATOM	2783	CB	ARG	G	429	−10.088	46.405	−3.920	1.00	14.93		C
  ATOM	2784	CG	ARG	G	429	−8.949	45.999	−2.999	1.00	16.26		C
  ATOM	2785	CD	ARG	G	429	−8.954	44.502	−2.732	1.00	19.79		C
  ATOM	2786	NE	ARG	G	429	−7.694	44.046	−2.152	1.00	22.68		N
  ATOM	2787	CZ	ARG	G	429	−7.270	44.369	−0.935	1.00	23.54		C
  ATOM	2788	NH1	ARG	G	429	−7.998	45.170	−0.168	1.00	22.87		N
  ATOM	2789	NH2	ARG	G	429	−6.107	43.912	−0.492	1.00	23.53		N
  ATOM	2790	C	ARG	G	429	−10.989	46.304	−6.256	1.00	14.35		C
  ATOM	2791	O	ARG	G	429	−11.653	45.268	−6.287	1.00	14.62		O
  ATOM	2792	N	GLY	G	430	−11.306	47.386	−6.961	1.00	13.67		N
  ATOM	2793	CA	GLY	G	430	−12.201	47.311	−8.110	1.00	12.80		C
  ATOM	2794	C	GLY	G	430	−11.870	46.136	−9.009	1.00	12.11		C
  ATOM	2795	O	GLY	G	430	−10.707	45.903	−9.338	1.00	12.18		O
  ATOM	2796	N	ILE	G	431	−12.892	45.374	−9.380	1.00	11.58		N
  ATOM	2797	CA	ILE	G	431	−12.700	44.155	−10.157	1.00	10.76		C
  ATOM	2798	CB	ILE	G	431	−13.777	43.106	−9.812	1.00	10.43		C
  ATOM	2799	CG1	ILE	G	431	−13.615	42.625	−8.368	1.00	10.95		C
  ATOM	2800	CD1	ILE	G	431	−14.920	42.259	−7.695	1.00	12.08		C
  ATOM	2801	CG2	ILE	G	431	−13.720	41.940	−10.785	1.00	10.07		C
  ATOM	2802	C	ILE	G	431	−12.770	44.465	−11.651	1.00	10.68		C
  ATOM	2803	O	ILE	G	431	−13.790	44.954	−12.136	1.00	10.40		O
  ATOM	2804	N	ILE	G	432	−11.677	44.225	−12.373	1.00	10.90		N
  ATOM	2805	CA	ILE	G	432	−11.658	44.482	−13.815	1.00	11.42		C
  ATOM	2806	CB	ILE	G	432	−10.276	44.936	−14.327	1.00	11.63		C
  ATOM	2807	CG1	ILE	G	432	−9.411	45.460	−13.180	1.00	12.68		C
  ATOM	2808	CD1	ILE	G	432	−7.977	45.738	−13.579	1.00	13.89		C
  ATOM	2809	CG2	ILE	G	432	−10.432	45.992	−15.412	1.00	12.24		C
  ATOM	2810	C	ILE	G	432	−12.118	43.290	−14.648	1.00	11.41		C
  ATOM	2811	O	ILE	G	432	−12.834	43.463	−15.635	1.00	11.63		O
  ATOM	2812	N	LYS	G	433	−11.505	42.136	−14.405	1.00	11.52		N
  ATOM	2813	CA	LYS	G	433	−11.792	40.950	−15.203	1.00	11.96		C
  ATOM	2814	CB	LYS	G	433	−10.516	40.392	−15.837	1.00	12.31		C
  ATOM	2815	CG	LYS	G	433	−10.770	39.317	−16.885	1.00	14.42		C
  ATOM	2816	CD	LYS	G	433	−9.723	39.348	−17.987	1.00	16.74		C
  ATOM	2817	CE	LYS	G	433	−9.997	38.283	−19.038	1.00	17.08		C
  ATOM	2818	NZ	LYS	G	433	−9.612	38.735	−20.404	1.00	17.30		N
  ATOM	2819	C	LYS	G	433	−12.496	39.873	−14.387	1.00	11.65		C
  ATOM	2820	O	LYS	G	433	−12.479	39.899	−13.156	1.00	11.48		O
  ATOM	2821	N	THR	G	434	−13.143	38.946	−15.086	1.00	11.28		N
  ATOM	2822	CA	THR	G	434	−13.816	37.821	−14.445	1.00	11.21		C
  ATOM	2823	CB	THR	G	434	−15.222	38.216	−13.955	1.00	11.30		C
  ATOM	2824	OG1	THR	G	434	−15.963	37.037	−13.619	1.00	11.83		O
  ATOM	2825	CG2	THR	G	434	−15.966	38.988	−15.035	1.00	11.84		C
  ATOM	2826	C	THR	G	434	−13.939	36.646	−15.415	1.00	10.94		C
  ATOM	2827	O	THR	G	434	−14.257	36.836	−16.589	1.00	10.93		O
  ATOM	2828	N	PHE	G	435	−13.628	35.442	−14.939	1.00	11.10		N
  ATOM	2829	CA	PHE	G	435	−12.871	34.486	−15.744	1.00	11.96		C
  ATOM	2830	CB	PHE	G	435	−11.673	33.929	−14.977	1.00	11.51		C
  ATOM	2831	CG	PHE	G	435	−10.437	34.772	−15.100	1.00	11.19		C
  ATOM	2832	CD1	PHE	G	435	−9.910	35.409	−13.989	1.00	10.86		C
  ATOM	2833	CE1	PHE	G	435	−8.824	36.254	−14.107	1.00	10.24		C
  ATOM	2834	CZ	PHE	G	435	−8.286	36.516	−15.352	1.00	9.89		C
  ATOM	2835	CE2	PHE	G	435	−8.834	35.927	−16.474	1.00	10.78		C
  ATOM	2836	CD2	PHE	G	435	−9.920	35.082	−16.348	1.00	11.14		C
  ATOM	2837	C	PHE	G	435	−13.678	33.371	−16.403	1.00	13.00		C
  ATOM	2838	O	PHE	G	435	−14.218	32.494	−15.726	1.00	13.03		O
  ATOM	2839	N	SER	G	436	−13.506	33.272	−17.717	1.00	13.89		N
  ATOM	2840	CA	SER	G	436	−14.276	32.356	−18.546	1.00	14.67		C
  ATOM	2841	CB	SER	G	436	−14.391	32.910	−19.969	1.00	15.04		C
  ATOM	2842	OG	SER	G	436	−15.702	33.377	−20.235	1.00	16.58		O
  ATOM	2843	C	SER	G	436	−13.627	30.975	−18.578	1.00	14.75		C
  ATOM	2844	O	SER	G	436	−13.081	30.559	−19.601	1.00	14.75		O
  ATOM	2845	N	ASN	G	437	−13.713	30.256	−17.465	1.00	14.44		N
  ATOM	2846	CA	ASN	G	437	−13.595	28.805	−17.496	1.00	14.35		C
  ATOM	2847	CB	ASN	G	437	−14.935	28.179	−17.896	1.00	14.75		C
  ATOM	2848	CG	ASN	G	437	−14.999	26.690	−17.610	1.00	15.51		C
  ATOM	2849	OD1	ASN	G	437	−15.013	26.275	−16.450	1.00	16.85		O
  ATOM	2850	ND2	ASN	G	437	−15.246	25.906	−18.652	1.00	16.10		N
  ATOM	2851	C	ASN	G	437	−12.497	28.371	−18.464	1.00	13.69		C
  ATOM	2852	O	ASN	G	437	−12.754	27.652	−19.430	1.00	13.40		O
  ATOM	2853	N	GLY	G	438	−11.290	28.880	−18.237	1.00	13.39		N
  ATOM	2854	CA	GLY	G	438	−10.183	28.701	−19.170	1.00	12.92		C
  ATOM	2855	C	GLY	G	438	−8.839	28.941	−18.510	1.00	12.72		C
  ATOM	2856	O	GLY	G	438	−8.620	28.538	−17.367	1.00	12.83		O
  ATOM	2857	N	CYS	G	439	−7.971	29.677	−19.195	1.00	12.17		N
  ATOM	2858	CA	CYS	G	439	−6.654	29.999	−18.658	1.00	11.52		C
  ATOM	2859	CB	CYS	G	439	−5.696	28.822	−18.844	1.00	11.68		C
  ATOM	2860	SG	CYS	G	439	−3.974	29.301	−19.104	1.00	12.89		S
  ATOM	2861	C	CYS	G	439	−6.077	31.258	−19.297	1.00	10.95		C
  ATOM	2862	O	CYS	G	439	−5.762	31.275	−20.488	1.00	10.77		O
  ATOM	2863	N	ASP	G	440	−5.921	32.303	−18.490	1.00	10.41		N
  ATOM	2864	CA	ASP	G	440	−5.546	33.619	−18.993	1.00	10.06		C
  ATOM	2865	CB	ASP	G	440	−6.685	34.620	−18.778	1.00	10.85		C
  ATOM	2866	CG	ASP	G	440	−7.418	34.956	−20.062	1.00	13.11		C
  ATOM	2867	OD1	ASP	G	440	−6.891	35.765	−20.854	1.00	14.97		O
  ATOM	2868	OD2	ASP	G	440	−8.559	34.479	−20.237	1.00	15.27		O
  ATOM	2869	C	ASP	G	440	−4.276	34.131	−18.318	1.00	9.01		C
  ATOM	2870	O	ASP	G	440	−3.793	33.542	−17.350	1.00	9.09		O
  ATOM	2871	N	TYR	G	441	−3.806	35.287	−18.778	1.00	7.92		N
  ATOM	2872	CA	TYR	G	441	−2.645	35.959	−18.199	1.00	7.24		C
  ATOM	2873	CB	TYR	G	441	−1.457	35.871	−19.165	1.00	7.04		C
  ATOM	2874	CG	TYR	G	441	−0.227	36.631	−18.724	1.00	6.77		C
  ATOM	2875	CD1	TYR	G	441	0.762	36.008	−17.974	1.00	7.41		C
  ATOM	2876	CE1	TYR	G	441	1.902	36.688	−17.593	1.00	6.79		C
  ATOM	2877	CZ	TYR	G	441	2.106	37.980	−18.034	1.00	6.49		C
  ATOM	2878	OH	TYR	G	441	3.230	38.670	−17.635	1.00	5.09		O
  ATOM	2879	CE2	TYR	G	441	1.157	38.606	−18.817	1.00	7.52		C
  ATOM	2880	CD2	TYR	G	441	0.017	37.918	−19.186	1.00	7.12		C
  ATOM	2881	C	TYR	G	441	−3.005	37.421	−17.946	1.00	6.89		C
  ATOM	2882	O	TYR	G	441	−3.809	38.000	−18.677	1.00	7.12		O
  ATOM	2883	N	VAL	G	442	−2.452	37.999	−16.886	1.00	6.73		N
  ATOM	2884	CA	VAL	G	442	−2.612	39.427	−16.615	1.00	6.78		C
  ATOM	2885	CB	VAL	G	442	−3.614	39.671	−15.472	1.00	6.51		C
  ATOM	2886	CG1	VAL	G	442	−5.041	39.483	−15.967	1.00	7.38		C
  ATOM	2887	CG2	VAL	G	442	−3.322	38.742	−14.303	1.00	6.00		C
  ATOM	2888	C	VAL	G	442	−1.262	40.025	−16.234	1.00	7.13		C
  ATOM	2889	O	VAL	G	442	−0.272	39.301	−16.134	1.00	7.77		O
  ATOM	2890	N	SER	G	443	−1.210	41.335	−16.022	1.00	7.12		N
  ATOM	2891	CA	SER	G	443	0.062	41.970	−15.700	1.00	7.64		C
  ATOM	2892	CB	SER	G	443	0.770	42.447	−16.969	1.00	7.83		C
  ATOM	2893	OG	SER	G	443	0.637	43.847	−17.131	1.00	7.99		O
  ATOM	2894	C	SER	G	443	−0.051	43.104	−14.690	1.00	8.16		C
  ATOM	2895	O	SER	G	443	−1.142	43.607	−14.420	1.00	8.69		O
  ATOM	2896	N	ASN	G	444	1.086	43.484	−14.117	1.00	8.73		N
  ATOM	2897	CA	ASN	G	444	1.139	44.600	−13.184	1.00	9.50		C
  ATOM	2898	CB	ASN	G	444	2.521	44.684	−12.538	1.00	9.65		C
  ATOM	2899	CG	ASN	G	444	3.256	43.357	−12.565	1.00	10.64		C
  ATOM	2900	OD1	ASN	G	444	2.641	42.291	−12.498	1.00	12.28		O
  ATOM	2901	ND2	ASN	G	444	4.578	43.416	−12.685	1.00	11.75		N
  ATOM	2902	C	ASN	G	444	0.791	45.922	−13.857	1.00	10.24		C
  ATOM	2903	O	ASN	G	444	1.086	46.126	−15.034	1.00	9.89		O
  ATOM	2904	N	LYS	G	445	0.266	46.855	−13.069	1.00	11.63		N
  ATOM	2905	CA	LYS	G	445	−0.752	47.787	−13.545	1.00	13.07		C
  ATOM	2906	CB	LYS	G	445	−0.107	49.048	−14.123	1.00	13.70		C
  ATOM	2907	CG	LYS	G	445	−1.068	50.216	−14.307	1.00	15.80		C
  ATOM	2908	CD	LYS	G	445	−2.384	49.986	−13.575	1.00	18.31		C
  ATOM	2909	CE	LYS	G	445	−2.166	49.766	−12.086	1.00	19.03		C
  ATOM	2910	NZ	LYS	G	445	−1.048	50.592	−11.554	1.00	20.02		N
  ATOM	2911	C	LYS	G	445	−1.681	47.147	−14.572	1.00	12.96		C
  ATOM	2912	O	LYS	G	445	−1.258	46.313	−15.372	1.00	13.24		O
  ATOM	2913	N	GLY	G	446	−2.943	47.559	−14.558	1.00	13.08		N
  ATOM	2914	CA	GLY	G	446	−4.051	46.616	−14.597	1.00	12.42		C
  ATOM	2915	C	GLY	G	446	−4.212	45.900	−13.272	1.00	11.83		C
  ATOM	2916	O	GLY	G	446	−4.832	46.426	−12.347	1.00	12.44		O
  ATOM	2917	N	VAL	G	447	−3.517	44.777	−13.126	1.00	10.63		N
  ATOM	2918	CA	VAL	G	447	−3.875	43.795	−12.114	1.00	10.01		C
  ATOM	2919	CB	VAL	G	447	−3.898	42.365	−12.681	1.00	9.97		C
  ATOM	2920	CG1	VAL	G	447	−4.591	41.422	−11.708	1.00	10.51		C
  ATOM	2921	CG2	VAL	G	447	−4.594	42.345	−14.033	1.00	10.50		C
  ATOM	2922	C	VAL	G	447	−2.978	43.851	−10.882	1.00	9.53		C
  ATOM	2923	O	VAL	G	447	−1.761	44.008	−10.985	1.00	9.61		O
  ATOM	2924	N	ASP	G	448	−3.586	43.575	−9.735	1.00	9.16		N
  ATOM	2925	CA	ASP	G	448	−2.956	43.763	−8.437	1.00	8.75		C
  ATOM	2926	CB	ASP	G	448	−3.515	45.022	−7.771	1.00	9.22		C
  ATOM	2927	CG	ASP	G	448	−2.579	45.599	−6.729	1.00	11.44		C
  ATOM	2928	OD1	ASP	G	448	−1.725	44.849	−6.212	1.00	13.83		O
  ATOM	2929	OD2	ASP	G	448	−2.713	46.799	−6.409	1.00	14.13		O
  ATOM	2930	C	ASP	G	448	−3.313	42.546	−7.598	1.00	8.18		C
  ATOM	2931	O	ASP	G	448	−2.555	42.122	−6.725	1.00	8.06		O
  ATOM	2932	N	THR	G	449	−4.451	41.949	−7.933	1.00	7.63		N
  ATOM	2933	CA	THR	G	449	−4.991	40.823	−7.192	1.00	6.80		C
  ATOM	2934	CB	THR	G	449	−5.988	41.293	−6.116	1.00	6.89		C
  ATOM	2935	OG1	THR	G	449	−5.284	41.584	−4.902	1.00	6.16		O
  ATOM	2936	CG2	THR	G	449	−7.032	40.219	−5.848	1.00	7.55		C
  ATOM	2937	C	THR	G	449	−5.717	39.906	−8.164	1.00	6.53		C
  ATOM	2938	O	THR	G	449	−6.385	40.370	−9.087	1.00	6.59		O
  ATOM	2939	N	VAL	G	450	−5.536	38.603	−7.989	1.00	6.07		N
  ATOM	2940	CA	VAL	G	450	−6.531	37.646	−8.434	1.00	6.02		C
  ATOM	2941	CB	VAL	G	450	−5.981	36.723	−9.535	1.00	5.61		C
  ATOM	2942	CG1	VAL	G	450	−5.377	37.545	−10.663	1.00	5.32		C
  ATOM	2943	CG2	VAL	G	450	−4.954	35.761	−8.958	1.00	5.55		C
  ATOM	2944	C	VAL	G	450	−7.021	36.811	−7.263	1.00	6.37		C
  ATOM	2945	O	VAL	G	450	−6.299	36.609	−6.287	1.00	6.54		O
  ATOM	2946	N	SER	G	451	−8.307	36.486	−7.288	1.00	6.41		N
  ATOM	2947	CA	SER	G	451	−8.857	35.507	−6.370	1.00	6.70		C
  ATOM	2948	CB	SER	G	451	−9.995	36.120	−5.553	1.00	7.13		C
  ATOM	2949	OG	SER	G	451	−10.537	37.254	−6.207	1.00	9.26		O
  ATOM	2950	C	SER	G	451	−9.354	34.292	−7.139	1.00	6.47		C
  ATOM	2951	O	SER	G	451	−9.896	34.423	−8.238	1.00	6.54		O
  ATOM	2952	N	VAL	G	452	−8.962	33.116	−6.664	1.00	6.56		N
  ATOM	2953	CA	VAL	G	452	−9.578	31.868	−7.091	1.00	6.31		C
  ATOM	2954	CB	VAL	G	452	−8.516	30.849	−7.542	1.00	5.74		C
  ATOM	2955	CG1	VAL	G	452	−9.170	29.688	−8.275	1.00	5.06		C
  ATOM	2956	CG2	VAL	G	452	−7.471	31.523	−8.419	1.00	5.56		C
  ATOM	2957	C	VAL	G	452	−10.381	31.264	−5.944	1.00	6.60		C
  ATOM	2958	O	VAL	G	452	−9.861	31.079	−4.844	1.00	7.04		O
  ATOM	2959	N	GLY	G	453	−11.652	30.975	−6.198	1.00	6.54		N
  ATOM	2960	CA	GLY	G	453	−12.581	30.650	−5.124	1.00	6.43		C
  ATOM	2961	C	GLY	G	453	−12.375	31.548	−3.920	1.00	6.09		C
  ATOM	2962	O	GLY	G	453	−12.581	32.759	−3.999	1.00	5.90		O
  ATOM	2963	N	ASN	G	454	−11.872	30.971	−2.833	1.00	6.02		N
  ATOM	2964	CA	ASN	G	454	−11.672	31.727	−1.603	1.00	6.39		C
  ATOM	2965	CB	ASN	G	454	−12.335	31.027	−0.420	1.00	6.81		C
  ATOM	2966	CG	ASN	G	454	−13.717	31.567	−0.135	1.00	8.99		C
  ATOM	2967	OD1	ASN	G	454	−13.867	32.523	0.625	1.00	11.67		O
  ATOM	2968	ND2	ASN	G	454	−14.693	31.112	−0.911	1.00	10.25		N
  ATOM	2969	C	ASN	G	454	−10.211	32.020	−1.296	1.00	6.15		C
  ATOM	2970	O	ASN	G	454	−9.900	32.765	−0.367	1.00	6.47		O
  ATOM	2971	N	THR	G	455	−9.322	31.491	−2.128	1.00	5.40		N
  ATOM	2972	CA	THR	G	455	−7.912	31.841	−2.053	1.00	4.53		C
  ATOM	2973	CB	THR	G	455	−7.033	30.774	−2.724	1.00	4.70		C
  ATOM	2974	OG1	THR	G	455	−7.344	29.486	−2.180	1.00	5.28		O
  ATOM	2975	CG2	THR	G	455	−5.560	31.074	−2.491	1.00	5.57		C
  ATOM	2976	C	THR	G	455	−7.659	33.187	−2.717	1.00	4.01		C
  ATOM	2977	O	THR	G	455	−8.312	33.540	−3.698	1.00	3.78		O
  ATOM	2978	N	LEU	G	456	−6.716	33.943	−2.165	1.00	3.87		N
  ATOM	2979	CA	LEU	G	456	−6.355	35.237	−2.726	1.00	4.05		C
  ATOM	2980	CB	LEU	G	456	−6.684	36.360	−1.742	1.00	3.95		C
  ATOM	2981	CG	LEU	G	456	−6.595	37.779	−2.306	1.00	3.76		C
  ATOM	2982	CD1	LEU	G	456	−7.572	37.962	−3.457	1.00	5.35		C
  ATOM	2983	CD2	LEU	G	456	−6.845	38.809	−1.216	1.00	4.10		C
  ATOM	2984	C	LEU	G	456	−4.879	35.288	−3.105	1.00	4.47		C
  ATOM	2985	O	LEU	G	456	−4.006	35.028	−2.276	1.00	4.94		O
  ATOM	2986	N	TYR	G	457	−4.609	35.652	−4.355	1.00	4.59		N
  ATOM	2987	CA	TYR	G	457	−3.242	35.786	−4.849	1.00	4.60		C
  ATOM	2988	CB	TYR	G	457	−3.056	34.938	−6.113	1.00	4.71		C
  ATOM	2989	CG	TYR	G	457	−3.201	33.447	−5.888	1.00	5.62		C
  ATOM	2990	CD1	TYR	G	457	−4.451	32.838	−5.896	1.00	7.09		C
  ATOM	2991	CE1	TYR	G	457	−4.582	31.473	−5.712	1.00	8.22		C
  ATOM	2992	CZ	TYR	G	457	−3.456	30.699	−5.533	1.00	8.06		C
  ATOM	2993	OH	TYR	G	457	−3.580	29.341	−5.349	1.00	8.80		O
  ATOM	2994	CE2	TYR	G	457	−2.204	31.276	−5.547	1.00	7.18		C
  ATOM	2995	CD2	TYR	G	457	−2.083	32.639	−5.735	1.00	6.66		C
  ATOM	2996	C	TYR	G	457	−2.924	37.256	−5.152	1.00	4.46		C
  ATOM	2997	O	TYR	G	457	−3.742	37.959	−5.745	1.00	4.92		O
  ATOM	2998	N	TYR	G	458	−1.727	37.706	−4.772	1.00	3.90		N
  ATOM	2999	CA	TYR	G	458	−1.312	39.118	−4.919	1.00	3.26		C
  ATOM	3000	CB	TYR	G	458	−0.740	39.635	−3.582	1.00	3.16		C
  ATOM	3001	CG	TYR	G	458	−1.716	39.659	−2.411	1.00	3.29		C
  ATOM	3002	CD1	TYR	G	458	−1.782	38.602	−1.509	1.00	3.93		C
  ATOM	3003	CE1	TYR	G	458	−2.632	38.646	−0.412	1.00	4.90		C
  ATOM	3004	CZ	TYR	G	458	−3.395	39.773	−0.185	1.00	5.12		C
  ATOM	3005	OH	TYR	G	458	−4.250	39.817	0.893	1.00	5.42		O
  ATOM	3006	CE2	TYR	G	458	−3.311	40.852	−1.039	1.00	4.72		C
  ATOM	3007	CD2	TYR	G	458	−2.457	40.801	−2.128	1.00	3.89		C
  ATOM	3008	C	TYR	G	458	−0.248	39.290	−6.043	1.00	3.04		C
  ATOM	3009	O	TYR	G	458	0.749	38.569	−6.041	1.00	3.37		O
  ATOM	3010	N	VAL	G	459	−0.351	40.348	−6.866	1.00	2.71		N
  ATOM	3011	CA	VAL	G	459	0.376	40.435	−8.177	1.00	2.61		C
  ATOM	3012	CB	VAL	G	459	−0.589	40.554	−9.380	1.00	2.22		C
  ATOM	3013	CG1	VAL	G	459	0.154	40.287	−10.682	1.00	2.62		C
  ATOM	3014	CG2	VAL	G	459	−1.756	39.589	−9.224	1.00	2.61		C
  ATOM	3015	C	VAL	G	459	1.609	41.392	−8.360	1.00	3.03		C
  ATOM	3016	O	VAL	G	459	2.575	41.281	−7.604	1.00	3.21		O
  ATOM	3017	N	ASN	G	460	1.708	42.037	−9.537	1.00	106.93		N
  ATOM	3018	CA	ASN	G	460	2.714	43.111	−9.870	1.00	95.54		C
  ATOM	3019	CB	ASN	G	460	3.598	43.589	−8.700	1.00	20.00		C
  ATOM	3020	CG	ASN	G	460	4.310	44.931	−9.000	1.00	20.00		C
  ATOM	3021	OD1	ASN	G	460	3.713	45.851	−9.563	1.00	20.00		O
  ATOM	3022	ND2	ASN	G	460	5.548	45.065	−8.532	1.00	20.00		N
  ATOM	3023	C	ASN	G	460	3.403	43.322	−11.247	1.00	99.41		C
  ATOM	3024	O	ASN	G	460	3.869	44.430	−11.523	1.00	108.91		O
  ATOM	3025	N	LYS	G	461	3.568	42.271	−12.055	1.00	97.04		N
  ATOM	3026	CA	LYS	G	461	4.464	42.327	−13.236	1.00	105.93		C
  ATOM	3027	CB	LYS	G	461	5.335	41.068	−13.312	1.00	20.00		C
  ATOM	3028	CG	LYS	G	461	6.382	40.951	−12.209	1.00	20.00		C
  ATOM	3029	CD	LYS	G	461	7.131	39.623	−12.296	1.00	20.00		C
  ATOM	3030	CE	LYS	G	461	8.255	39.536	−11.268	1.00	20.00		C
  ATOM	3031	NZ	LYS	G	461	8.886	38.184	−11.223	1.00	20.00		N
  ATOM	3032	C	LYS	G	461	3.727	42.546	−14.573	1.00	102.28		C
  ATOM	3033	O	LYS	G	461	2.507	42.702	−14.590	1.00	105.02		O
  ATOM	3034	N	GLN	G	462	4.464	42.556	−15.685	1.00	96.68		N
  ATOM	3035	CA	GLN	G	462	3.854	42.633	−17.020	1.00	105.71		C
  ATOM	3036	CB	GLN	G	462	3.988	44.047	−17.593	1.00	20.00		C
  ATOM	3037	CG	GLN	G	462	3.237	45.115	−16.814	1.00	20.00		C
  ATOM	3038	CD	GLN	G	462	3.484	46.512	−17.353	1.00	20.00		C
  ATOM	3039	OE1	GLN	G	462	4.527	46.786	−17.947	1.00	20.00		O
  ATOM	3040	NE2	GLN	G	462	2.529	47.408	−17.135	1.00	20.00		N
  ATOM	3041	C	GLN	G	462	4.479	41.626	−17.986	1.00	101.50		C
  ATOM	3042	O	GLN	G	462	5.701	41.501	−18.051	1.00	105.94		O
  ATOM	3043	N	GLU	G	463	3.646	40.946	−18.769	1.00	98.92		N
  ATOM	3044	CA	GLU	G	463	4.140	39.928	−19.693	1.00	108.59		C
  ATOM	3045	CB	GLU	G	463	3.380	38.612	−19.512	1.00	20.00		C
  ATOM	3046	CG	GLU	G	463	3.682	37.900	−18.201	1.00	20.00		C
  ATOM	3047	CD	GLU	G	463	2.842	36.650	−18.005	1.00	20.00		C
  ATOM	3048	OE1	GLU	G	463	2.003	36.350	−18.881	1.00	20.00		O
  ATOM	3049	OE2	GLU	G	463	3.075	35.929	−17.011	1.00	20.00		O
  ATOM	3050	C	GLU	G	463	4.074	40.384	−21.146	1.00	116.39		C
  ATOM	3051	O	GLU	G	463	3.025	40.814	−21.627	1.00	118.70		O
  ATOM	3052	N	GLY	G	464	5.200	40.272	−21.845	1.00	127.70		N
  ATOM	3053	CA	GLY	G	464	5.261	40.610	−23.261	1.00	143.17		C
  ATOM	3054	C	GLY	G	464	4.710	39.509	−24.146	1.00	149.77		C
  ATOM	3055	O	GLY	G	464	4.443	38.400	−23.681	1.00	155.06		O
  ATOM	3056	N	LYS	G	465	4.544	39.816	−25.428	1.00	153.73		N
  ATOM	3057	CA	LYS	G	465	3.994	38.862	−26.384	1.00	153.69		C
  ATOM	3058	CB	LYS	G	465	4.816	37.571	−26.389	1.00	20.00		C
  ATOM	3059	CG	LYS	G	465	6.228	37.735	−26.927	1.00	20.00		C
  ATOM	3060	CD	LYS	G	465	6.996	36.424	−26.873	1.00	20.00		C
  ATOM	3061	CE	LYS	G	465	8.402	36.585	−27.426	1.00	20.00		C
  ATOM	3062	NZ	LYS	G	465	9.172	35.312	−27.363	1.00	20.00		N
  ATOM	3063	C	LYS	G	465	2.532	38.552	−26.080	1.00	155.37		C
  ATOM	3064	O	LYS	G	465	1.710	38.437	−26.988	1.00	155.20		O
  ATOM	3065	N	GLU	G	472	−0.074	35.733	−32.259	1.00	145.47		N
  ATOM	3066	CA	GLU	G	472	−0.706	34.866	−33.247	1.00	151.12		C
  ATOM	3067	CB	GLU	G	472	0.178	34.736	−34.490	1.00	20.00		C
  ATOM	3068	CG	GLU	G	472	0.339	36.028	−35.276	1.00	20.00		C
  ATOM	3069	CD	GLU	G	472	1.271	35.876	−36.463	1.00	20.00		C
  ATOM	3070	OE1	GLU	G	472	1.954	34.835	−36.556	1.00	20.00		O
  ATOM	3071	OE2	GLU	G	472	1.325	36.803	−37.299	1.00	20.00		O
  ATOM	3072	C	GLU	G	472	−0.993	33.486	−32.663	1.00	153.35		C
  ATOM	3073	O	GLU	G	472	−0.069	32.755	−32.306	1.00	159.41		O
  ATOM	3074	N	PRO	G	473	−2.282	33.131	−32.557	1.00	150.51		N
  ATOM	3075	CA	PRO	G	473	−2.668	31.819	−32.081	1.00	141.97		C
  ATOM	3076	CB	PRO	G	473	−3.684	32.152	−30.990	1.00	20.00		C
  ATOM	3077	CG	PRO	G	473	−4.311	33.467	−31.446	1.00	20.00		C
  ATOM	3078	CD	PRO	G	473	−3.423	34.059	−32.523	1.00	20.00		C
  ATOM	3079	C	PRO	G	473	−3.357	31.051	−33.200	1.00	135.14		C
  ATOM	3080	O	PRO	G	473	−3.883	31.662	−34.131	1.00	144.93		O
  ATOM	3081	N	ILE	G	474	−3.379	29.727	−33.098	1.00	118.07		N
  ATOM	3082	CA	ILE	G	474	−3.969	28.899	−34.142	1.00	105.14		C
  ATOM	3083	CB	ILE	G	474	−3.193	29.027	−35.469	1.00	20.00		C
  ATOM	3084	CG1	ILE	G	474	−3.315	30.446	−36.028	1.00	20.00		C
  ATOM	3085	CD1	ILE	G	474	−2.352	30.745	−37.156	1.00	20.00		C
  ATOM	3086	CG2	ILE	G	474	−3.696	28.008	−36.481	1.00	20.00		C
  ATOM	3087	C	ILE	G	474	−4.007	27.432	−33.730	1.00	104.75		C
  ATOM	3088	O	ILE	G	474	−3.033	26.702	−33.915	1.00	111.83		O
  ATOM	3089	N	ILE	G	475	−5.149	26.992	−33.213	1.00	94.65		N
  ATOM	3090	CA	ILE	G	475	−5.249	25.667	−32.611	1.00	79.88		C
  ATOM	3091	CB	ILE	G	475	−5.443	25.753	−31.087	1.00	20.00		C
  ATOM	3092	CG1	ILE	G	475	−4.165	26.260	−30.413	1.00	20.00		C
  ATOM	3093	CD1	ILE	G	475	−4.414	27.012	−29.122	1.00	20.00		C
  ATOM	3094	CG2	ILE	G	475	−5.873	24.406	−30.525	1.00	20.00		C
  ATOM	3095	C	ILE	G	475	−6.374	24.834	−33.223	1.00	79.52		C
  ATOM	3096	O	ILE	G	475	−7.554	25.117	−33.016	1.00	82.70		O
  ATOM	3097	N	ASN	G	476	−5.996	23.761	−33.912	1.00	69.64		N
  ATOM	3098	CA	ASN	G	476	−6.962	22.821	−34.472	1.00	68.88		C
  ATOM	3099	CB	ASN	G	476	−6.365	22.100	−35.683	1.00	20.00		C
  ATOM	3100	CG	ASN	G	476	−6.170	23.019	−36.872	1.00	20.00		C
  ATOM	3101	OD1	ASN	G	476	−6.855	24.032	−37.009	1.00	20.00		O
  ATOM	3102	ND2	ASN	G	476	−5.251	22.651	−37.756	1.00	20.00		N
  ATOM	3103	C	ASN	G	476	−7.434	21.799	−33.443	1.00	67.13		C
  ATOM	3104	O	ASN	G	476	−6.628	21.229	−32.707	1.00	73.10		O
  ATOM	3105	N	PHE	G	477	−8.735	21.527	−33.438	1.00	64.95		N
  ATOM	3106	CA	PHE	G	477	−9.327	20.624	−32.455	1.00	68.13		C
  ATOM	3107	CB	PHE	G	477	−10.854	20.711	−32.493	1.00	20.00		C
  ATOM	3108	CG	PHE	G	477	−11.397	22.047	−32.079	1.00	20.00		C
  ATOM	3109	CD1	PHE	G	477	−11.580	22.352	−30.740	1.00	20.00		C
  ATOM	3110	CE1	PHE	G	477	−12.086	23.580	−30.357	1.00	20.00		C
  ATOM	3111	CZ	PHE	G	477	−12.426	24.514	−31.316	1.00	20.00		C
  ATOM	3112	CE2	PHE	G	477	−12.257	24.219	−32.654	1.00	20.00		C
  ATOM	3113	CD2	PHE	G	477	−11.750	22.989	−33.030	1.00	20.00		C
  ATOM	3114	C	PHE	G	477	−8.890	19.180	−32.672	1.00	65.57		C
  ATOM	3115	O	PHE	G	477	−9.270	18.290	−31.911	1.00	49.83		O
  ATOM	3116	N	TYR	G	478	−8.204	18.931	−33.782	1.00	51.97		N
  ATOM	3117	CA	TYR	G	478	−7.618	17.619	−34.036	1.00	52.01		C
  ATOM	3118	CB	TYR	G	478	−7.356	17.428	−35.530	1.00	20.00		C
  ATOM	3119	CG	TYR	G	478	−8.609	17.426	−36.372	1.00	20.00		C
  ATOM	3120	CD1	TYR	G	478	−9.337	16.259	−36.567	1.00	20.00		C
  ATOM	3121	CE1	TYR	G	478	−10.489	16.255	−37.329	1.00	20.00		C
  ATOM	3122	CZ	TYR	G	478	−10.930	17.429	−37.902	1.00	20.00		C
  ATOM	3123	OH	TYR	G	478	−12.078	17.432	−38.658	1.00	20.00		O
  ATOM	3124	CE2	TYR	G	478	−10.230	18.602	−37.717	1.00	20.00		C
  ATOM	3125	CD2	TYR	G	478	−9.079	18.596	−36.954	1.00	20.00		C
  ATOM	3126	C	TYR	G	478	−6.325	17.459	−33.251	1.00	66.63		C
  ATOM	3127	O	TYR	G	478	−5.548	16.535	−33.492	1.00	63.45		O
  ATOM	3128	N	ASP	G	479	−6.062	18.423	−32.375	1.00	65.34		N
  ATOM	3129	CA	ASP	G	479	−4.928	18.351	−31.469	1.00	65.32		C
  ATOM	3130	CB	ASP	G	479	−4.205	19.698	−31.413	1.00	20.00		C
  ATOM	3131	CG	ASP	G	479	−3.509	20.038	−32.717	1.00	20.00		C
  ATOM	3132	OD1	ASP	G	479	−3.293	19.119	−33.534	1.00	20.00		O
  ATOM	3133	OD2	ASP	G	479	−3.184	21.225	−32.930	1.00	20.00		O
  ATOM	3134	C	ASP	G	479	−5.383	17.937	−30.076	1.00	64.83		C
  ATOM	3135	O	ASP	G	479	−4.561	17.574	−29.236	1.00	60.42		O
  ATOM	3136	N	PRO	G	480	−6.707	17.893	−29.861	1.00	47.60		N
  ATOM	3137	CA	PRO	G	480	−7.262	17.523	−28.572	1.00	46.52		C
  ATOM	3138	CB	PRO	G	480	−8.509	18.400	−28.480	1.00	20.00		C
  ATOM	3139	CG	PRO	G	480	−8.954	18.565	−29.904	1.00	20.00		C
  ATOM	3140	CD	PRO	G	480	−7.755	18.332	−30.799	1.00	20.00		C
  ATOM	3141	C	PRO	G	480	−7.662	16.056	−28.548	1.00	52.36		C
  ATOM	3142	O	PRO	G	480	−8.804	15.721	−28.860	1.00	64.15		O
  ATOM	3143	N	LEU	G	481	−6.698	15.183	−28.281	1.00	62.90		N
  ATOM	3144	CA	LEU	G	481	−6.977	13.759	−28.138	1.00	54.24		C
  ATOM	3145	CB	LEU	G	481	−6.143	12.944	−29.128	1.00	20.00		C
  ATOM	3146	CG	LEU	G	481	−6.449	13.142	−30.613	1.00	20.00		C
  ATOM	3147	CD1	LEU	G	481	−5.475	12.348	−31.471	1.00	20.00		C
  ATOM	3148	CD2	LEU	G	481	−7.884	12.747	−30.922	1.00	20.00		C
  ATOM	3149	C	LEU	G	481	−6.700	13.285	−26.717	1.00	59.81		C
  ATOM	3150	O	LEU	G	481	−6.199	14.041	−25.884	1.00	64.98		O
  ATOM	3151	N	VAL	G	482	−6.956	12.008	−26.470	1.00	59.66		N
  ATOM	3152	CA	VAL	G	482	−6.588	11.404	−25.203	1.00	49.67		C
  ATOM	3153	CB	VAL	G	482	−7.741	10.579	−24.619	1.00	20.00		C
  ATOM	3154	CG1	VAL	G	482	−7.390	10.116	−23.220	1.00	20.00		C
  ATOM	3155	CG2	VAL	G	482	−9.021	11.398	−24.607	1.00	20.00		C
  ATOM	3156	C	VAL	G	482	−5.357	10.525	−25.372	1.00	53.03		C
  ATOM	3157	O	VAL	G	482	−5.147	9.945	−26.437	1.00	46.27		O
  ATOM	3158	N	PHE	G	483	−4.464	10.579	−24.387	1.00	61.61		N
  ATOM	3159	CA	PHE	G	483	−3.282	9.723	−24.370	1.00	65.03		C
  ATOM	3160	CB	PHE	G	483	−2.011	10.562	−24.235	1.00	20.00		C
  ATOM	3161	CG	PHE	G	483	−1.788	11.500	−25.385	1.00	20.00		C
  ATOM	3162	CD1	PHE	G	483	−1.173	11.059	−26.546	1.00	20.00		C
  ATOM	3163	CE1	PHE	G	483	−1.039	11.897	−27.632	1.00	20.00		C
  ATOM	3164	CZ	PHE	G	483	−1.577	13.170	−27.589	1.00	20.00		C
  ATOM	3165	CE2	PHE	G	483	−2.199	13.618	−26.442	1.00	20.00		C
  ATOM	3166	CD2	PHE	G	483	−2.315	12.781	−25.355	1.00	20.00		C
  ATOM	3167	C	PHE	G	483	−3.358	8.663	−23.275	1.00	71.00		C
  ATOM	3168	O	PHE	G	483	−2.688	8.776	−22.248	1.00	100.44		O
  ATOM	3169	N	PRO	G	484	−4.338	7.759	−23.403	1.00	54.44		N
  ATOM	3170	CA	PRO	G	484	−4.502	6.677	−22.459	1.00	47.46		C
  ATOM	3171	CB	PRO	G	484	−5.761	7.096	−21.701	1.00	20.00		C
  ATOM	3172	CG	PRO	G	484	−6.554	7.922	−22.714	1.00	20.00		C
  ATOM	3173	CD	PRO	G	484	−5.649	8.206	−23.894	1.00	20.00		C
  ATOM	3174	C	PRO	G	484	−4.778	5.378	−23.204	1.00	41.56		C
  ATOM	3175	O	PRO	G	484	−5.689	5.321	−24.029	1.00	46.53		O
  ATOM	3176	N	SER	G	485	−3.961	4.363	−22.958	1.00	46.30		N
  ATOM	3177	CA	SER	G	485	−4.081	3.108	−23.686	1.00	49.30		C
  ATOM	3178	CB	SER	G	485	−3.559	1.943	−22.841	1.00	20.00		C
  ATOM	3179	OG	SER	G	485	−4.215	1.884	−21.588	1.00	20.00		O
  ATOM	3180	C	SER	G	485	−5.521	2.856	−24.147	1.00	41.24		C
  ATOM	3181	O	SER	G	485	−5.809	2.890	−25.345	1.00	46.93		O
  ATOM	3182	N	ASP	G	486	−6.437	2.720	−23.190	1.00	49.48		N
  ATOM	3183	CA	ASP	G	486	−7.816	2.321	−23.485	1.00	37.44		C
  ATOM	3184	CB	ASP	G	486	−8.659	2.287	−22.205	1.00	20.00		C
  ATOM	3185	CG	ASP	G	486	−8.296	1.125	−21.289	1.00	20.00		C
  ATOM	3186	OD1	ASP	G	486	−7.611	0.188	−21.746	1.00	20.00		O
  ATOM	3187	OD2	ASP	G	486	−8.637	1.184	−20.089	1.00	20.00		O
  ATOM	3188	C	ASP	G	486	−8.447	3.271	−24.491	1.00	45.66		C
  ATOM	3189	O	ASP	G	486	−9.005	2.844	−25.501	1.00	39.86		O
  ATOM	3190	N	GLU	G	487	−8.317	4.566	−24.225	1.00	49.20		N
  ATOM	3191	CA	GLU	G	487	−8.853	5.585	−25.116	1.00	45.70		C
  ATOM	3192	CB	GLU	G	487	−8.656	6.982	−24.525	1.00	20.00		C
  ATOM	3193	CG	GLU	G	487	−9.449	7.237	−23.251	1.00	20.00		C
  ATOM	3194	CD	GLU	G	487	−9.144	8.590	−22.635	1.00	20.00		C
  ATOM	3195	OE1	GLU	G	487	−8.175	9.245	−23.078	1.00	20.00		O
  ATOM	3196	OE2	GLU	G	487	−9.865	8.988	−21.695	1.00	20.00		O
  ATOM	3197	C	GLU	G	487	−8.222	5.504	−26.501	1.00	41.48		C
  ATOM	3198	O	GLU	G	487	−8.914	5.623	−27.512	1.00	48.92		O
  ATOM	3199	N	PHE	G	488	−6.910	5.306	−26.545	1.00	42.16		N
  ATOM	3200	CA	PHE	G	488	−6.206	5.215	−27.815	1.00	39.33		C
  ATOM	3201	CB	PHE	G	488	−4.701	5.086	−27.590	1.00	20.00		C
  ATOM	3202	CG	PHE	G	488	−4.074	6.308	−26.992	1.00	20.00		C
  ATOM	3203	CD1	PHE	G	488	−3.910	7.454	−27.747	1.00	20.00		C
  ATOM	3204	CE1	PHE	G	488	−3.320	8.574	−27.202	1.00	20.00		C
  ATOM	3205	CZ	PHE	G	488	−2.847	8.542	−25.898	1.00	20.00		C
  ATOM	3206	CE2	PHE	G	488	−3.006	7.404	−25.136	1.00	20.00		C
  ATOM	3207	CD2	PHE	G	488	−3.630	6.302	−25.678	1.00	20.00		C
  ATOM	3208	C	PHE	G	488	−6.724	4.040	−28.634	1.00	43.06		C
  ATOM	3209	O	PHE	G	488	−7.101	4.203	−29.794	1.00	61.71		O
  ATOM	3210	N	ASP	G	489	−6.910	2.906	−27.972	1.00	41.95		N
  ATOM	3211	CA	ASP	G	489	−7.330	1.695	−28.658	1.00	42.75		C
  ATOM	3212	CB	ASP	G	489	−7.257	0.499	−27.717	1.00	20.00		C
  ATOM	3213	CG	ASP	G	489	−5.838	0.116	−27.389	1.00	20.00		C
  ATOM	3214	OD1	ASP	G	489	−4.920	0.637	−28.056	1.00	20.00		O
  ATOM	3215	OD2	ASP	G	489	−5.636	−0.633	−26.411	1.00	20.00		O
  ATOM	3216	C	ASP	G	489	−8.733	1.825	−29.233	1.00	45.61		C
  ATOM	3217	O	ASP	G	489	−9.066	1.181	−30.226	1.00	54.39		O
  ATOM	3218	N	ALA	G	490	−9.568	2.622	−28.575	1.00	42.89		N
  ATOM	3219	CA	ALA	G	490	−10.929	2.848	−29.044	1.00	38.40		C
  ATOM	3220	CB	ALA	G	490	−11.760	3.516	−27.963	1.00	20.00		C
  ATOM	3221	C	ALA	G	490	−10.932	3.687	−30.315	1.00	39.67		C
  ATOM	3222	O	ALA	G	490	−11.651	3.386	−31.267	1.00	56.80		O
  ATOM	3223	N	SER	G	491	−10.138	4.752	−30.315	1.00	40.38		N
  ATOM	3224	CA	SER	G	491	−9.984	5.586	−31.499	1.00	41.77		C
  ATOM	3225	CB	SER	G	491	−9.155	6.831	−31.176	1.00	20.00		C
  ATOM	3226	OG	SER	G	491	−7.806	6.490	−30.912	1.00	20.00		O
  ATOM	3227	C	SER	G	491	−9.333	4.801	−32.631	1.00	39.01		C
  ATOM	3228	O	SER	G	491	−9.688	4.967	−33.798	1.00	36.91		O
  ATOM	3229	N	ILE	G	492	−8.387	3.938	−32.278	1.00	38.11		N
  ATOM	3230	CA	ILE	G	492	−7.741	3.077	−33.259	1.00	41.21		C
  ATOM	3231	CB	ILE	G	492	−6.630	2.211	−32.620	1.00	20.00		C
  ATOM	3232	CG1	ILE	G	492	−5.507	3.092	−32.061	1.00	20.00		C
  ATOM	3233	CD1	ILE	G	492	−4.533	2.346	−31.163	1.00	20.00		C
  ATOM	3234	CG2	ILE	G	492	−6.067	1.219	−33.634	1.00	20.00		C
  ATOM	3235	C	ILE	G	492	−8.773	2.170	−33.916	1.00	39.22		C
  ATOM	3236	O	ILE	G	492	−8.778	2.008	−35.135	1.00	47.54		O
  ATOM	3237	N	SER	G	493	−9.703	1.662	−33.111	1.00	41.64		N
  ATOM	3238	CA	SER	G	493	−10.786	0.819	−33.612	1.00	35.15		C
  ATOM	3239	CB	SER	G	493	−11.579	0.202	−32.454	1.00	20.00		C
  ATOM	3240	OG	SER	G	493	−12.267	1.196	−31.716	1.00	20.00		O
  ATOM	3241	C	SER	G	493	−11.716	1.614	−34.523	1.00	47.90		C
  ATOM	3242	O	SER	G	493	−12.169	1.115	−35.555	1.00	50.94		O
  ATOM	3243	N	GLN	G	494	−11.936	2.877	−34.169	1.00	42.51		N
  ATOM	3244	CA	GLN	G	494	−12.789	3.766	−34.955	1.00	41.96		C
  ATOM	3245	CB	GLN	G	494	−13.107	5.036	−34.167	1.00	20.00		C
  ATOM	3246	CG	GLN	G	494	−13.991	4.813	−32.955	1.00	20.00		C
  ATOM	3247	CD	GLN	G	494	−14.211	6.084	−32.163	1.00	20.00		C
  ATOM	3248	OE1	GLN	G	494	−13.406	7.013	−32.223	1.00	20.00		O
  ATOM	3249	NE2	GLN	G	494	−15.317	6.140	−31.430	1.00	20.00		N
  ATOM	3250	C	GLN	G	494	−12.151	4.137	−36.291	1.00	33.86		C
  ATOM	3251	O	GLN	G	494	−12.829	4.195	−37.318	1.00	54.89		O
  ATOM	3252	N	VAL	G	495	−10.881	4.523	−36.241	1.00	34.99		N
  ATOM	3253	CA	VAL	G	495	−10.108	4.772	−37.451	1.00	38.42		C
  ATOM	3254	CB	VAL	G	495	−8.642	5.097	−37.120	1.00	20.00		C
  ATOM	3255	CG1	VAL	G	495	−7.840	5.297	−38.394	1.00	20.00		C
  ATOM	3256	CG2	VAL	G	495	−8.562	6.327	−36.231	1.00	20.00		C
  ATOM	3257	C	VAL	G	495	−10.152	3.573	−38.393	1.00	42.74		C
  ATOM	3258	O	VAL	G	495	−10.424	3.720	−39.584	1.00	44.00		O
  ATOM	3259	N	ASN	G	496	−9.947	2.383	−37.838	1.00	42.45		N
  ATOM	3260	CA	ASN	G	496	−9.967	1.147	−38.617	1.00	43.01		C
  ATOM	3261	CB	ASN	G	496	−9.572	−0.046	−37.743	1.00	20.00		C
  ATOM	3262	CG	ASN	G	496	−8.118	0.000	−37.319	1.00	20.00		C
  ATOM	3263	OD1	ASN	G	496	−7.293	0.648	−37.965	1.00	20.00		O
  ATOM	3264	ND2	ASN	G	496	−7.796	−0.684	−36.226	1.00	20.00		N
  ATOM	3265	C	ASN	G	496	−11.305	0.875	−39.310	1.00	43.13		C
  ATOM	3266	O	ASN	G	496	−11.334	0.405	−40.448	1.00	54.76		O
  ATOM	3267	N	GLU	G	497	−12.407	1.099	−38.598	1.00	42.08		N
  ATOM	3268	CA	GLU	G	497	−13.738	0.938	−39.183	1.00	43.13		C
  ATOM	3269	CB	GLU	G	497	−14.827	1.144	−38.127	1.00	20.00		C
  ATOM	3270	CG	GLU	G	497	−14.937	0.018	−37.110	1.00	20.00		C
  ATOM	3271	CD	GLU	G	497	−15.946	0.316	−36.017	1.00	20.00		C
  ATOM	3272	OE1	GLU	G	497	−16.552	1.408	−36.049	1.00	20.00		O
  ATOM	3273	OE2	GLU	G	497	−16.177	−0.566	−35.164	1.00	20.00		O
  ATOM	3274	C	GLU	G	497	−13.937	1.915	−40.337	1.00	49.77		C
  ATOM	3275	O	GLU	G	497	−14.552	1.580	−41.349	1.00	42.88		O
  ATOM	3276	N	LYS	G	498	−13.367	3.108	−40.195	1.00	41.82		N
  ATOM	3277	CA	LYS	G	498	−13.435	4.123	−41.240	1.00	53.60		C
  ATOM	3278	CB	LYS	G	498	−12.968	5.479	−40.705	1.00	20.00		C
  ATOM	3279	CG	LYS	G	498	−13.937	6.125	−39.728	1.00	20.00		C
  ATOM	3280	CD	LYS	G	498	−13.439	7.484	−39.269	1.00	20.00		C
  ATOM	3281	CE	LYS	G	498	−14.393	8.108	−38.265	1.00	20.00		C
  ATOM	3282	NZ	LYS	G	498	−13.896	9.421	−37.768	1.00	20.00		N
  ATOM	3283	C	LYS	G	498	−12.611	3.724	−42.458	1.00	55.29		C
  ATOM	3284	O	LYS	G	498	−13.033	3.926	−43.594	1.00	61.06		O
  ATOM	3285	N	ILE	G	499	−11.430	3.165	−42.214	1.00	52.22		N
  ATOM	3286	CA	ILE	G	499	−10.609	2.604	−43.284	1.00	48.26		C
  ATOM	3287	CB	ILE	G	499	−9.296	2.009	−42.729	1.00	20.00		C
  ATOM	3288	CG1	ILE	G	499	−8.446	3.101	−42.072	1.00	20.00		C
  ATOM	3289	CD1	ILE	G	499	−7.506	2.582	−41.002	1.00	20.00		C
  ATOM	3290	CG2	ILE	G	499	−8.516	1.288	−43.825	1.00	20.00		C
  ATOM	3291	C	ILE	G	499	−11.376	1.515	−44.031	1.00	49.07		C
  ATOM	3292	O	ILE	G	499	−11.282	1.398	−45.253	1.00	58.45		O
  ATOM	3293	N	ASN	G	500	−12.183	0.764	−43.288	1.00	51.02		N
  ATOM	3294	CA	ASN	G	500	−12.992	−0.307	−43.857	1.00	52.06		C
  ATOM	3295	CB	ASN	G	500	−13.500	−1.238	−42.748	1.00	20.00		C
  ATOM	3296	CG	ASN	G	500	−14.173	−2.487	−43.292	1.00	20.00		C
  ATOM	3297	OD1	ASN	G	500	−13.795	−3.005	−44.342	1.00	20.00		O
  ATOM	3298	ND2	ASN	G	500	−15.127	−3.019	−42.536	1.00	20.00		N
  ATOM	3299	C	ASN	G	500	−14.161	0.250	−44.659	1.00	48.31		C
  ATOM	3300	O	ASN	G	500	−14.645	−0.386	−45.596	1.00	56.89		O
  ATOM	3301	N	GLN	G	501	−14.582	1.461	−44.312	1.00	55.87		N
  ATOM	3302	CA	GLN	G	501	−15.607	2.160	−45.074	1.00	53.55		C
  ATOM	3303	CB	GLN	G	501	−16.243	3.258	−44.222	1.00	20.00		C
  ATOM	3304	CG	GLN	G	501	−17.012	2.741	−43.015	1.00	20.00		C
  ATOM	3305	CD	GLN	G	501	−17.674	3.857	−42.226	1.00	20.00		C
  ATOM	3306	OE1	GLN	G	501	−17.178	4.985	−42.189	1.00	20.00		O
  ATOM	3307	NE2	GLN	G	501	−18.772	3.536	−41.553	1.00	20.00		N
  ATOM	3308	C	GLN	G	501	−15.030	2.751	−46.357	1.00	45.67		C
  ATOM	3309	O	GLN	G	501	−15.627	2.633	−47.429	1.00	58.31		O
  ATOM	3310	N	SER	G	502	−13.824	3.303	−46.258	1.00	43.44		N
  ATOM	3311	CA	SER	G	502	−13.117	3.801	−47.432	1.00	45.40		C
  ATOM	3312	CB	SER	G	502	−11.789	4.468	−47.045	1.00	20.00		C
  ATOM	3313	OG	SER	G	502	−10.928	3.572	−46.361	1.00	20.00		O
  ATOM	3314	C	SER	G	502	−12.891	2.677	−48.436	1.00	55.15		C
  ATOM	3315	O	SER	G	502	−13.234	2.819	−49.610	1.00	52.57		O
  ATOM	3316	N	LEU	G	503	−12.552	1.495	−47.922	1.00	55.35		N
  ATOM	3317	CA	LEU	G	503	−12.227	0.349	−48.768	1.00	52.12		C
  ATOM	3318	CB	LEU	G	503	−11.591	−0.778	−47.943	1.00	20.00		C
  ATOM	3319	CG	LEU	G	503	−10.187	−0.535	−47.373	1.00	20.00		C
  ATOM	3320	CD1	LEU	G	503	−9.810	−1.609	−46.357	1.00	20.00		C
  ATOM	3321	CD2	LEU	G	503	−9.144	−0.458	−48.481	1.00	20.00		C
  ATOM	3322	C	LEU	G	503	−13.471	−0.159	−49.489	1.00	55.74		C
  ATOM	3323	O	LEU	G	503	−13.402	−0.586	−50.642	1.00	57.75		O
  ATOM	3324	N	ALA	G	504	−14.618	−0.046	−48.826	1.00	57.22		N
  ATOM	3325	CA	ALA	G	504	−15.893	−0.410	−49.436	1.00	59.12		C
  ATOM	3326	CB	ALA	G	504	−16.981	−0.532	−48.377	1.00	20.00		C
  ATOM	3327	C	ALA	G	504	−16.293	0.605	−50.499	1.00	58.10		C
  ATOM	3328	O	ALA	G	504	−16.773	0.241	−51.573	1.00	63.64		O
  ATOM	3329	N	PHE	G	505	−16.075	1.881	−50.198	1.00	58.17		N
  ATOM	3330	CA	PHE	G	505	−16.303	2.940	−51.171	1.00	56.56		C
  ATOM	3331	CB	PHE	G	505	−15.991	4.309	−50.564	1.00	20.00		C
  ATOM	3332	CG	PHE	G	505	−16.870	4.665	−49.405	1.00	20.00		C
  ATOM	3333	CD1	PHE	G	505	−18.185	5.035	−49.615	1.00	20.00		C
  ATOM	3334	CE1	PHE	G	505	−19.045	5.205	−48.555	1.00	20.00		C
  ATOM	3335	CZ	PHE	G	505	−18.617	4.934	−47.269	1.00	20.00		C
  ATOM	3336	CE2	PHE	G	505	−17.314	4.545	−47.047	1.00	20.00		C
  ATOM	3337	CD2	PHE	G	505	−16.446	4.423	−48.109	1.00	20.00		C
  ATOM	3338	C	PHE	G	505	−15.462	2.715	−52.416	1.00	60.12		C
  ATOM	3339	O	PHE	G	505	−15.922	2.939	−53.535	1.00	65.46		O
  ATOM	3340	N	ILE	G	506	−14.235	2.242	−52.213	1.00	56.10		N
  ATOM	3341	CA	ILE	G	506	−13.325	1.960	−53.320	1.00	57.32		C
  ATOM	3342	CB	ILE	G	506	−11.911	1.590	−52.825	1.00	20.00		C
  ATOM	3343	CG1	ILE	G	506	−11.167	2.839	−52.352	1.00	20.00		C
  ATOM	3344	CD1	ILE	G	506	−10.010	2.533	−51.425	1.00	20.00		C
  ATOM	3345	CG2	ILE	G	506	−11.126	0.882	−53.925	1.00	20.00		C
  ATOM	3346	C	ILE	G	506	−13.845	0.812	−54.170	1.00	67.33		C
  ATOM	3347	O	ILE	G	506	−13.674	0.803	−55.390	1.00	76.99		O
  ATOM	3348	N	ARG	G	507	−14.325	−0.230	−53.503	1.00	67.87		N
  ATOM	3349	CA	ARG	G	507	−14.920	−1.360	−54.195	1.00	62.11		C
  ATOM	3350	CB	ARG	G	507	−15.328	−2.440	−53.196	1.00	20.00		C
  ATOM	3351	CG	ARG	G	507	−14.151	−3.082	−52.491	1.00	20.00		C
  ATOM	3352	CD	ARG	G	507	−14.592	−4.218	−51.585	1.00	20.00		C
  ATOM	3353	NE	ARG	G	507	−13.453	−4.836	−50.911	1.00	20.00		N
  ATOM	3354	CZ	ARG	G	507	−13.555	−5.749	−49.950	1.00	20.00		C
  ATOM	3355	NH1	ARG	G	507	−14.748	−6.221	−49.609	1.00	20.00		N
  ATOM	3356	NH2	ARG	G	507	−12.459	−6.278	−49.422	1.00	20.00		N
  ATOM	3357	C	ARG	G	507	−16.119	−0.920	−55.026	1.00	67.30		C
  ATOM	3358	O	ARG	G	507	−16.131	−1.079	−56.247	1.00	67.02		O
  ATOM	3359	N	LYS	G	508	−17.080	−0.274	−54.375	1.00	66.83		N
  ATOM	3360	CA	LYS	G	508	−18.220	0.295	−55.078	1.00	68.12		C
  ATOM	3361	CB	LYS	G	508	−19.052	1.156	−54.133	1.00	20.00		C
  ATOM	3362	CG	LYS	G	508	−19.813	0.362	−53.096	1.00	20.00		C
  ATOM	3363	CD	LYS	G	508	−20.707	1.269	−52.270	1.00	20.00		C
  ATOM	3364	CE	LYS	G	508	−21.508	0.479	−51.248	1.00	20.00		C
  ATOM	3365	NZ	LYS	G	508	−22.370	1.366	−50.421	1.00	20.00		N
  ATOM	3366	C	LYS	G	508	−17.758	1.131	−56.261	1.00	65.22		C
  ATOM	3367	O	LYS	G	508	−18.149	0.880	−57.402	1.00	72.34		O
  ATOM	3368	N	SER	G	509	−16.859	2.071	−55.990	1.00	64.87		N
  ATOM	3369	CA	SER	G	509	−16.316	2.939	−57.028	1.00	56.47		C
  ATOM	3370	CB	SER	G	509	−15.268	3.896	−56.442	1.00	20.00		C
  ATOM	3371	OG	SER	G	509	−14.170	3.190	−55.888	1.00	20.00		O
  ATOM	3372	C	SER	G	509	−15.736	2.147	−58.205	1.00	56.96		C
  ATOM	3373	O	SER	G	509	−16.064	2.412	−59.363	1.00	65.57		O
  ATOM	3374	N	ASP	G	510	−14.906	1.154	−57.902	1.00	64.34		N
  ATOM	3375	CA	ASP	G	510	−14.282	0.340	−58.939	1.00	64.83		C
  ATOM	3376	CB	ASP	G	510	−13.338	−0.690	−58.316	1.00	20.00		C
  ATOM	3377	CG	ASP	G	510	−12.073	−0.063	−57.768	1.00	20.00		C
  ATOM	3378	OD1	ASP	G	510	−11.789	1.104	−58.112	1.00	20.00		O
  ATOM	3379	OD2	ASP	G	510	−11.361	−0.735	−56.993	1.00	20.00		O
  ATOM	3380	C	ASP	G	510	−15.339	−0.362	−59.782	1.00	62.11		C
  ATOM	3381	O	ASP	G	510	−15.346	−0.251	−61.008	1.00	67.61		O
  ATOM	3382	N	GLU	G	511	−16.244	−1.067	−59.112	1.00	64.95		N
  ATOM	3383	CA	GLU	G	511	−17.319	−1.774	−59.791	1.00	60.64		C
  ATOM	3384	CB	GLU	G	511	−18.359	−2.259	−58.780	1.00	20.00		C
  ATOM	3385	CG	GLU	G	511	−17.818	−3.293	−57.801	1.00	20.00		C
  ATOM	3386	CD	GLU	G	511	−18.840	−3.723	−56.760	1.00	20.00		C
  ATOM	3387	OE1	GLU	G	511	−19.857	−3.017	−56.585	1.00	20.00		O
  ATOM	3388	OE2	GLU	G	511	−18.603	−4.746	−56.083	1.00	20.00		O
  ATOM	3389	C	GLU	G	511	−17.970	−0.888	−60.842	1.00	59.91		C
  ATOM	3390	O	GLU	G	511	−18.090	−1.278	−62.003	1.00	55.45		O
  ATOM	3391	N	LEU	G	512	−18.270	0.349	−60.460	1.00	44.35		N
  ATOM	3392	CA	LEU	G	512	−18.978	1.259	−61.346	1.00	49.60		C
  ATOM	3393	CB	LEU	G	512	−19.424	2.511	−60.590	1.00	20.00		C
  ATOM	3394	CG	LEU	G	512	−20.377	2.256	−59.416	1.00	20.00		C
  ATOM	3395	CD1	LEU	G	512	−20.747	3.550	−58.696	1.00	20.00		C
  ATOM	3396	CD2	LEU	G	512	−21.624	1.499	−59.858	1.00	20.00		C
  ATOM	3397	C	LEU	G	512	−18.128	1.626	−62.557	1.00	58.00		C
  ATOM	3398	O	LEU	G	512	−18.542	1.415	−63.696	1.00	55.11		O
  ATOM	3399	N	LEU	G	513	−16.883	2.015	−62.305	1.00	57.91		N
  ATOM	3400	CA	LEU	G	513	−15.963	2.384	−63.378	1.00	57.49		C
  ATOM	3401	CB	LEU	G	513	−14.609	2.810	−62.801	1.00	20.00		C
  ATOM	3402	CG	LEU	G	513	−14.558	4.136	−62.038	1.00	20.00		C
  ATOM	3403	CD1	LEU	G	513	−13.242	4.263	−61.282	1.00	20.00		C
  ATOM	3404	CD2	LEU	G	513	−14.743	5.302	−62.996	1.00	20.00		C
  ATOM	3405	C	LEU	G	513	−15.775	1.231	−64.362	1.00	58.78		C
  ATOM	3406	O	LEU	G	513	−15.707	1.437	−65.574	1.00	59.88		O
  ATOM	3407	N	HIS	G	514	−15.708	0.015	−63.829	1.00	60.07		N
  ATOM	3408	CA	HIS	G	514	−15.540	−1.175	−64.652	1.00	62.82		C
  ATOM	3409	CB	HIS	G	514	−15.189	−2.383	−63.782	1.00	20.00		C
  ATOM	3410	CG	HIS	G	514	−13.924	−2.217	−63.001	1.00	20.00		C
  ATOM	3411	ND1	HIS	G	514	−12.683	−2.154	−63.598	1.00	20.00		N
  ATOM	3412	CE1	HIS	G	514	−11.757	−2.005	−62.668	1.00	20.00		C
  ATOM	3413	NE2	HIS	G	514	−12.351	−1.975	−61.489	1.00	20.00		N
  ATOM	3414	CD2	HIS	G	514	−13.706	−2.113	−61.669	1.00	20.00		C
  ATOM	3415	C	HIS	G	514	−16.796	−1.465	−65.463	1.00	65.10		C
  ATOM	3416	O	HIS	G	514	−16.745	−2.170	−66.470	1.00	66.73		O
  ATOM	3417	N	ASN	G	515	−17.926	−0.941	−65.000	1.00	63.45		N
  ATOM	3418	CA	ASN	G	515	−19.179	−1.062	−65.732	1.00	56.53		C
  ATOM	3419	CB	ASN	G	515	−20.370	−0.925	−64.783	1.00	20.00		C
  ATOM	3420	CG	ASN	G	515	−20.503	−2.107	−63.845	1.00	20.00		C
  ATOM	3421	OD1	ASN	G	515	−19.979	−3.190	−64.113	1.00	20.00		O
  ATOM	3422	ND2	ASN	G	515	−21.206	−1.906	−62.734	1.00	20.00		N
  ATOM	3423	C	ASN	G	515	−19.289	−0.043	−66.860	1.00	60.06		C
  ATOM	3424	O	ASN	G	515	−19.825	−0.335	−67.928	1.00	66.48		O
  ATOM	3425	N	VAL	G	516	−18.818	1.168	−66.598	1.00	54.29		N
  ATOM	3426	CA	VAL	G	516	−18.783	2.200	−67.620	1.00	52.70		C
  ATOM	3427	CB	VAL	G	516	−18.233	3.518	−67.056	1.00	20.00		C
  ATOM	3428	CG1	VAL	G	516	−18.151	4.566	−68.153	1.00	20.00		C
  ATOM	3429	CG2	VAL	G	516	−19.098	4.003	−65.904	1.00	20.00		C
  ATOM	3430	C	VAL	G	516	−17.910	1.753	−68.784	1.00	60.10		C
  ATOM	3431	O	VAL	G	516	−18.340	1.765	−69.937	1.00	61.55		O
  ATOM	3432	N	ASN	G	517	−16.733	1.232	−68.455	1.00	69.10		N
  ATOM	3433	CA	ASN	G	517	−15.793	0.770	−69.466	1.00	67.75		C
  ATOM	3434	CB	ASN	G	517	−14.564	0.137	−68.807	1.00	20.00		C
  ATOM	3435	CG	ASN	G	517	−13.665	1.163	−68.146	1.00	20.00		C
  ATOM	3436	OD1	ASN	G	517	−13.646	2.330	−68.534	1.00	20.00		O
  ATOM	3437	ND2	ASN	G	517	−12.873	0.718	−67.177	1.00	20.00		N
  ATOM	3438	C	ASN	G	517	−16.439	−0.209	−70.444	1.00	71.17		C
  ATOM	3439	O	ASN	G	517	−16.188	−0.154	−71.649	1.00	66.42		O
  ATOM	3440	N	ALA	G	518	−17.351	−1.033	−69.935	1.00	72.11		N
  ATOM	3441	CA	ALA	G	518	−18.026	−2.024	−70.764	1.00	74.82		C
  ATOM	3442	CB	ALA	G	518	−18.558	−3.164	−69.912	1.00	20.00		C
  ATOM	3443	C	ALA	G	518	−19.145	−1.399	−71.593	1.00	70.11		C
  ATOM	3444	O	ALA	G	518	−19.363	−1.789	−72.739	1.00	65.18		O
  ATOM	3445	N	GLY	G	519	−19.865	−0.448	−71.006	1.00	56.07		N
  ATOM	3446	CA	GLY	G	519	−20.825	0.357	−71.760	1.00	53.01		C
  ATOM	3447	C	GLY	G	519	−20.156	1.166	−72.856	1.00	63.58		C
  ATOM	3448	O	GLY	G	519	−20.684	1.295	−73.962	1.00	69.35		O
  ATOM	3449	N	LYS	G	520	−18.950	1.647	−72.561	1.00	58.33		N
  ATOM	3450	CA	LYS	G	520	−18.122	2.361	−73.533	1.00	53.44		C
  ATOM	3451	CB	LYS	G	520	−16.848	2.877	−72.865	1.00	20.00		C
  ATOM	3452	CG	LYS	G	520	−17.081	3.958	−71.831	1.00	20.00		C
  ATOM	3453	CD	LYS	G	520	−15.781	4.341	−71.152	1.00	20.00		C
  ATOM	3454	CE	LYS	G	520	−15.984	5.482	−70.173	1.00	20.00		C
  ATOM	3455	NZ	LYS	G	520	−14.753	5.730	−69.376	1.00	20.00		N
  ATOM	3456	C	LYS	G	520	−17.746	1.492	−74.731	1.00	58.24		C
  ATOM	3457	O	LYS	G	520	−17.445	2.006	−75.810	1.00	48.60		O
  ATOM	3458	N	SER	G	521	−17.583	0.198	−74.478	1.00	67.19		N
  ATOM	3459	CA	SER	G	521	−17.366	−0.776	−75.542	1.00	60.42		C
  ATOM	3460	CB	SER	G	521	−16.953	−2.131	−74.959	1.00	20.00		C
  ATOM	3461	OG	SER	G	521	−18.028	−2.751	−74.272	1.00	20.00		O
  ATOM	3462	C	SER	G	521	−18.588	−0.942	−76.444	1.00	54.19		C
  ATOM	3463	O	SER	G	521	−18.456	−1.004	−77.664	1.00	65.36		O
  ATOM	3464	N	THR	G	522	−19.761	−1.120	−75.840	1.00	50.09		N
  ATOM	3465	CA	THR	G	522	−21.001	−1.210	−76.608	1.00	57.59		C
  ATOM	3466	CB	THR	G	522	−22.235	−1.431	−75.705	1.00	20.00		C
  ATOM	3467	OG1	THR	G	522	−22.276	−0.422	−74.689	1.00	20.00		O
  ATOM	3468	CG2	THR	G	522	−22.196	−2.805	−75.058	1.00	20.00		C
  ATOM	3469	C	THR	G	522	−21.206	0.063	−77.423	1.00	59.16		C
  ATOM	3470	O	THR	G	522	−21.384	0.010	−78.640	1.00	65.90		O
  ATOM	3471	N	THR	G	523	−21.024	1.205	−76.768	1.00	52.59		N
  ATOM	3472	CA	THR	G	523	−21.234	2.498	−77.404	1.00	42.19		C
  ATOM	3473	CB	THR	G	523	−20.961	3.638	−76.423	1.00	20.00		C
  ATOM	3474	OG1	THR	G	523	−19.578	3.622	−76.049	1.00	20.00		O
  ATOM	3475	CG2	THR	G	523	−21.819	3.467	−75.180	1.00	20.00		C
  ATOM	3476	C	THR	G	523	−20.352	2.676	−78.636	1.00	48.90		C
  ATOM	3477	O	THR	G	523	−20.786	3.238	−79.641	1.00	63.19		O
  ATOM	3478	N	ASN	G	524	−19.113	2.197	−78.553	1.00	52.51		N
  ATOM	3479	CA	ASN	G	524	−18.206	2.200	−79.701	1.00	57.54		C
  ATOM	3480	CB	ASN	G	524	−16.783	1.822	−79.276	1.00	20.00		C
  ATOM	3481	CG	ASN	G	524	−16.110	2.908	−78.457	1.00	20.00		C
  ATOM	3482	OD1	ASN	G	524	−16.515	4.069	−78.492	1.00	20.00		O
  ATOM	3483	ND2	ASN	G	524	−15.087	2.529	−77.699	1.00	20.00		N
  ATOM	3484	C	ASN	G	524	−18.669	1.296	−80.843	1.00	54.12		C
  ATOM	3485	O	ASN	G	524	−18.530	1.652	−82.013	1.00	61.31		O
  ATOM	3486	N	SER	G	525	−19.149	0.102	−80.502	1.00	48.97		N
  ATOM	3487	CA	SER	G	525	−19.658	−0.841	−81.499	1.00	64.81		C
  ATOM	3488	CB	SER	G	525	−20.077	−2.157	−80.838	1.00	61.22		C
  ATOM	3489	OG	SER	G	525	−18.947	−2.929	−80.475	1.00	85.90		O
  ATOM	3490	C	SER	G	525	−20.840	−0.249	−82.254	1.00	69.67		C
  ATOM	3491	O	SER	G	525	−21.093	−0.600	−83.406	1.00	72.60		O
  ATOM	3492	N	LYS	G	526	−21.592	0.610	−81.577	1.00	66.06		N
  ATOM	3493	CA	LYS	G	526	−22.723	1.280	−82.197	1.00	63.67		C
  ATOM	3494	CB	LYS	G	526	−23.675	1.815	−81.127	1.00	70.55		C
  ATOM	3495	CG	LYS	G	526	−24.473	0.741	−80.407	1.00	75.29		C
  ATOM	3496	CD	LYS	G	526	−25.171	1.313	−79.183	1.00	85.03		C
  ATOM	3497	CE	LYS	G	526	−25.776	0.219	−78.325	1.00	82.65		C
  ATOM	3498	NZ	LYS	G	526	−26.303	0.770	−77.048	1.00	73.89		N
  ATOM	3499	C	LYS	G	526	−22.259	2.417	−83.103	1.00	55.36		C
  ATOM	3500	O	LYS	G	526	−22.797	2.611	−84.191	1.00	70.69		O
  ATOM	3501	N	ILE	G	527	−21.275	3.181	−82.638	1.00	57.52		N
  ATOM	3502	CA	ILE	G	527	−20.718	4.273	−83.431	1.00	58.48		C
  ATOM	3503	CB	ILE	G	527	−19.545	4.966	−82.712	1.00	57.00		C
  ATOM	3504	CG1	ILE	G	527	−20.021	5.620	−81.415	1.00	49.07		C
  ATOM	3505	CD1	ILE	G	527	−20.228	7.116	−81.534	1.00	46.18		C
  ATOM	3506	CG2	ILE	G	527	−18.902	6.004	−83.621	1.00	52.63		C
  ATOM	3507	C	ILE	G	527	−20.224	3.758	−84.774	1.00	65.20		C
  ATOM	3508	O	ILE	G	527	−20.455	4.380	−85.810	1.00	66.48		O
  ATOM	3509	N	TYR	G	528	−19.487	2.652	−84.740	1.00	69.78		N
  ATOM	3510	CA	TYR	G	528	−18.985	2.034	−85.961	1.00	72.52		C
  ATOM	3511	CB	TYR	G	528	−18.268	0.712	−85.657	1.00	73.16		C
  ATOM	3512	CG	TYR	G	528	−17.130	0.810	−84.658	1.00	76.94		C
  ATOM	3513	CD1	TYR	G	528	−16.667	−0.323	−83.994	1.00	70.95		C
  ATOM	3514	CE1	TYR	G	528	−15.628	−0.245	−83.077	1.00	67.73		C
  ATOM	3515	CZ	TYR	G	528	−15.064	0.981	−82.789	1.00	71.89		C
  ATOM	3516	OH	TYR	G	528	−14.046	1.065	−81.866	1.00	75.44		O
  ATOM	3517	CE2	TYR	G	528	−15.505	2.121	−83.433	1.00	77.03		C
  ATOM	3518	CD2	TYR	G	528	−16.523	2.029	−84.373	1.00	77.84		C
  ATOM	3519	C	TYR	G	528	−20.130	1.796	−86.949	1.00	71.63		C
  ATOM	3520	O	TYR	G	528	−20.150	2.377	−88.036	1.00	84.20		O
  ATOM	3521	N	HIS	G	529	−21.116	1.002	−86.534	1.00	67.69		N
  ATOM	3522	CA	HIS	G	529	−22.239	0.633	−87.398	1.00	60.28		C
  ATOM	3523	CB	HIS	G	529	−23.215	−0.283	−86.659	1.00	67.84		C
  ATOM	3524	CG	HIS	G	529	−22.668	−1.645	−86.376	1.00	88.54		C
  ATOM	3525	ND1	HIS	G	529	−23.472	−2.756	−86.236	1.00	93.34		N
  ATOM	3526	CE1	HIS	G	529	−22.725	−3.802	−85.933	1.00	86.23		C
  ATOM	3527	NE2	HIS	G	529	−21.465	−3.410	−85.871	1.00	91.95		N
  ATOM	3528	CD2	HIS	G	529	−21.401	−2.067	−86.151	1.00	93.77		C
  ATOM	3529	C	HIS	G	529	−22.987	1.845	−87.944	1.00	63.30		C
  ATOM	3530	O	HIS	G	529	−23.453	1.828	−89.083	1.00	61.02		O
  ATOM	3531	N	ILE	G	530	−23.209	2.842	−87.091	1.00	59.79		N
  ATOM	3532	CA	ILE	G	530	−23.752	4.121	−87.543	1.00	45.70		C
  ATOM	3533	CB	ILE	G	530	−23.965	5.095	−86.374	1.00	40.57		C
  ATOM	3534	CG1	ILE	G	530	−25.130	4.627	−85.499	1.00	42.86		C
  ATOM	3535	CD1	ILE	G	530	−25.537	5.624	−84.437	1.00	51.01		C
  ATOM	3536	CG2	ILE	G	530	−24.224	6.501	−86.901	1.00	35.31		C
  ATOM	3537	C	ILE	G	530	−22.822	4.775	−88.557	1.00	57.52		C
  ATOM	3538	O	ILE	G	530	−23.260	5.253	−89.604	1.00	71.18		O
  ATOM	3539	N	GLU	G	531	−21.534	4.787	−88.234	1.00	67.55		N
  ATOM	3540	CA	GLU	G	531	−20.508	5.305	−89.129	1.00	69.79		C
  ATOM	3541	CB	GLU	G	531	−19.126	5.105	−88.505	1.00	84.02		C
  ATOM	3542	CG	GLU	G	531	−18.143	6.228	−88.780	1.00	104.22		C
  ATOM	3543	CD	GLU	G	531	−16.823	6.033	−88.058	1.00	116.08		C
  ATOM	3544	OE1	GLU	G	531	−16.849	5.706	−86.853	1.00	118.71		O
  ATOM	3545	OE2	GLU	G	531	−15.762	6.211	−88.693	1.00	119.69		O
  ATOM	3546	C	GLU	G	531	−20.567	4.624	−90.495	1.00	64.87		C
  ATOM	3547	O	GLU	G	531	−20.720	5.285	−91.522	1.00	55.58		O
  ATOM	3548	N	ASN	G	532	−20.409	3.304	−90.499	1.00	65.70		N
  ATOM	3549	CA	ASN	G	532	−20.502	2.516	−91.724	1.00	64.16		C
  ATOM	3550	CB	ASN	G	532	−20.351	1.026	−91.402	1.00	60.58		C
  ATOM	3551	CG	ASN	G	532	−20.304	0.165	−92.642	1.00	67.75		C
  ATOM	3552	OD1	ASN	G	532	−19.416	0.312	−93.481	1.00	53.59		O
  ATOM	3553	ND2	ASN	G	532	−21.285	−0.716	−92.786	1.00	61.81		N
  ATOM	3554	C	ASN	G	532	−21.809	2.759	−92.472	1.00	72.17		C
  ATOM	3555	O	ASN	G	532	−21.823	2.885	−93.696	1.00	85.75		O
  ATOM	3556	N	GLU	G	533	−22.907	2.812	−91.726	1.00	79.68		N
  ATOM	3557	CA	GLU	G	533	−24.220	3.041	−92.307	1.00	71.96		C
  ATOM	3558	CB	GLU	G	533	−25.300	2.936	−91.234	1.00	67.87		C
  ATOM	3559	CG	GLU	G	533	−26.680	2.653	−91.788	1.00	81.94		C
  ATOM	3560	CD	GLU	G	533	−26.710	1.397	−92.632	1.00	92.79		C
  ATOM	3561	OE1	GLU	G	533	−26.313	0.331	−92.119	1.00	95.90		O
  ATOM	3562	OE2	GLU	G	533	−26.989	1.501	−93.843	1.00	93.14		O
  ATOM	3563	C	GLU	G	533	−24.296	4.406	−92.974	1.00	68.54		C
  ATOM	3564	O	GLU	G	533	−25.101	4.616	−93.879	1.00	79.29		O
  ATOM	3565	N	ILE	G	534	−23.542	5.359	−92.440	1.00	69.50		N
  ATOM	3566	CA	ILE	G	534	−23.498	6.702	−93.003	1.00	72.55		C
  ATOM	3567	CB	ILE	G	534	−23.070	7.737	−91.956	1.00	79.55		C
  ATOM	3568	CG1	ILE	G	534	−24.053	7.740	−90.784	1.00	80.41		C
  ATOM	3569	CD1	ILE	G	534	−25.321	6.951	−91.049	1.00	89.38		C
  ATOM	3570	CG2	ILE	G	534	−22.981	9.118	−92.588	1.00	78.63		C
  ATOM	3571	C	ILE	G	534	−22.538	6.766	−94.180	1.00	74.92		C
  ATOM	3572	O	ILE	G	534	−22.589	7.693	−94.987	1.00	81.01		O
  ATOM	3573	N	ALA	G	535	−21.648	5.786	−94.255	1.00	79.52		N
  ATOM	3574	CA	ALA	G	535	−20.721	5.683	−95.368	1.00	82.64		C
  ATOM	3575	CB	ALA	G	535	−19.529	4.824	−94.974	1.00	75.39		C
  ATOM	3576	C	ALA	G	535	−21.416	5.115	−96.604	1.00	81.39		C
  ATOM	3577	O	ALA	G	535	−21.170	5.557	−97.727	1.00	85.54		O
  ATOM	3578	N	ARG	G	536	−22.325	4.171	−96.380	1.00	78.41		N
  ATOM	3579	CA	ARG	G	536	−23.115	3.581	−97.457	1.00	83.27		C
  ATOM	3580	CB	ARG	G	536	−23.781	2.287	−96.984	1.00	84.58		C
  ATOM	3581	CG	ARG	G	536	−22.808	1.180	−96.618	1.00	103.24		C
  ATOM	3582	CD	ARG	G	536	−23.316	−0.171	−97.085	1.00	114.72		C
  ATOM	3583	NE	ARG	G	536	−24.587	−0.515	−96.457	1.00	117.80		N
  ATOM	3584	CZ	ARG	G	536	−25.297	−1.600	−96.750	1.00	116.66		C
  ATOM	3585	NH1	ARG	G	536	−24.875	−2.439	−97.685	1.00	114.57		N
  ATOM	3586	NH2	ARG	G	536	−26.417	−1.862	−96.089	1.00	116.38		N
  ATOM	3587	C	ARG	G	536	−24.172	4.552	−97.973	1.00	82.20		C
  ATOM	3588	O	ARG	G	536	−24.315	4.737	−99.182	1.00	86.28		O
  ATOM	3589	N	ILE	G	537	−24.941	5.135	−97.058	1.00	77.08		N
  ATOM	3590	CA	ILE	G	537	−25.917	6.156	−97.430	1.00	66.79		C
  ATOM	3591	CB	ILE	G	537	−26.719	6.680	−96.216	1.00	64.76		C
  ATOM	3592	CG1	ILE	G	537	−27.614	5.583	−95.640	1.00	66.92		C
  ATOM	3593	CD1	ILE	G	537	−28.487	6.055	−94.493	1.00	70.83		C
  ATOM	3594	CG2	ILE	G	537	−27.593	7.848	−96.631	1.00	51.02		C
  ATOM	3595	C	ILE	G	537	−25.221	7.330	−98.108	1.00	74.94		C
  ATOM	3596	O	ILE	G	537	−25.824	8.043	−98.907	1.00	97.16		O
  ATOM	3597	N	LYS	G	538	−23.941	7.514	−97.804	1.00	75.09		N
  ATOM	3598	CA	LYS	G	538	−23.162	8.575	−98.427	1.00	90.28		C
  ATOM	3599	CB	LYS	G	538	−22.051	9.054	−97.491	1.00	93.73		C
  ATOM	3600	CG	LYS	G	538	−21.584	10.479	−97.760	1.00	96.60		C
  ATOM	3601	CD	LYS	G	538	−20.446	10.876	−96.830	1.00	95.37		C
  ATOM	3602	CE	LYS	G	538	−20.008	12.313	−97.067	1.00	100.63		C
  ATOM	3603	NZ	LYS	G	538	−18.989	12.750	−96.074	1.00	99.58		N
  ATOM	3604	C	LYS	G	538	−22.574	8.114	−99.754	1.00	102.20		C
  ATOM	3605	O	LYS	G	538	−21.940	8.891	−100.466	1.00	112.11		O
  ATOM	3606	N	LYS	G	539	−22.870	6.874	−100.126	1.00	105.15		N
  ATOM	3607	CA	LYS	G	539	−22.411	6.328	−101.396	1.00	105.65		C
  ATOM	3608	CB	LYS	G	539	−21.904	4.897	−101.211	1.00	110.12		C
  ATOM	3609	CG	LYS	G	539	−21.426	4.246	−102.498	1.00	113.31		C
  ATOM	3610	CD	LYS	G	539	−21.023	2.794	−102.284	1.00	114.26		C
  ATOM	3611	CE	LYS	G	539	−20.414	2.201	−103.550	1.00	118.39		C
  ATOM	3612	NZ	LYS	G	539	−19.511	1.047	−103.263	1.00	121.77		N
  ATOM	3613	C	LYS	G	539	−23.517	6.364	−102.444	1.00	108.88		C
  ATOM	3614	O	LYS	G	539	−23.375	5.808	−103.532	1.00	110.77		O
  ATOM	3615	N	LEU	G	540	−24.625	7.011	−102.102	1.00	111.50		N
  ATOM	3616	CA	LEU	G	540	−25.722	7.201	−103.038	1.00	110.31		C
  ATOM	3617	CB	LEU	G	540	−27.025	6.656	−102.451	1.00	101.19		C
  ATOM	3618	CG	LEU	G	540	−26.983	5.200	−101.978	1.00	94.26		C
  ATOM	3619	CD1	LEU	G	540	−28.376	4.691	−101.683	1.00	86.40		C
  ATOM	3620	CD2	LEU	G	540	−26.307	4.311	−103.004	1.00	84.54		C
  ATOM	3621	C	LEU	G	540	−25.865	8.679	−103.374	1.00	118.37		C
  ATOM	3622	O	LEU	G	540	−26.802	9.081	−104.064	1.00	116.71		O
  ATOM	3623	N	ILE	G	541	−24.894	9.474	−102.934	1.00	130.80		N
  ATOM	3624	CA	ILE	G	541	−24.844	10.896	−103.267	1.00	140.48		C
  ATOM	3625	CB	ILE	G	541	−25.701	11.746	−102.294	1.00	138.99		C
  ATOM	3626	CG1	ILE	G	541	−27.145	11.234	−102.257	1.00	133.30		C
  ATOM	3627	CD1	ILE	G	541	−28.050	11.879	−103.291	1.00	136.26		C
  ATOM	3628	CG2	ILE	G	541	−25.680	13.218	−102.707	1.00	136.12		C
  ATOM	3629	C	ILE	G	541	−23.407	11.410	−103.250	1.00	144.97		C
  ATOM	3630	O	ILE	G	541	−23.116	12.480	−103.783	1.00	145.83		O
  ATOM	3631	N	GLY	G	542	−22.519	10.663	−102.602	1.00	148.77		N
  ATOM	3632	CA	GLY	G	542	−21.119	11.060	−102.505	1.00	153.58		C
  ATOM	3633	C	GLY	G	542	−20.209	10.194	−103.357	1.00	160.45		C
  ATOM	3634	O	GLY	G	542	−20.636	9.643	−104.372	1.00	163.41		O
  ATOM	3635	N	GLU	G	543	−18.962	10.042	−102.921	1.00	163.83		N
  ATOM	3636	CA	GLU	G	543	−17.983	9.236	−103.649	1.00	165.52		C
  ATOM	3637	CB	GLU	G	543	−16.557	9.674	−103.305	1.00	158.94		C
  ATOM	3642	C	GLU	G	543	−18.156	7.742	−103.381	1.00	168.27		C
  ATOM	3643	O	GLU	G	543	−19.116	7.322	−102.736	1.00	167.37		O
  ATOM	3644	N	GLN	H	26	−24.590	4.282	7.491	1.00	23.62	B	N
  ATOM	3645	CA	GLN	H	26	−23.869	3.499	6.449	1.00	23.82	B	C
  ATOM	3646	CB	GLN	H	26	−22.633	2.827	7.055	1.00	23.94	B	C
  ATOM	3647	CG	GLN	H	26	−21.724	3.775	7.833	1.00	28.83	B	C
  ATOM	3648	CD	GLN	H	26	−22.314	4.205	9.165	1.00	36.36	B	C
  ATOM	3649	OE1	GLN	H	26	−23.057	5.183	9.238	1.00	39.09	B	O
  ATOM	3650	NE2	GLN	H	26	−21.891	3.545	10.238	1.00	37.86	B	N
  ATOM	3651	C	GLN	H	26	−24.797	2.460	5.813	1.00	23.09	B	C
  ATOM	3652	O	GLN	H	26	−25.818	2.096	6.397	1.00	24.21	B	O
  ATOM	3653	N	ASN	H	27	−24.543	2.146	4.544	1.00	20.98	B	N
  ATOM	3654	CA	ASN	H	27	−25.343	1.173	3.786	1.00	19.70	B	C
  ATOM	3655	CB	ASN	H	27	−26.642	1.832	3.269	1.00	20.41	B	C
  ATOM	3656	CG	ASN	H	27	−27.524	0.887	2.423	1.00	23.56	B	C
  ATOM	3657	OD1	ASN	H	27	−27.835	−0.233	2.837	1.00	24.42	B	O
  ATOM	3658	ND2	ASN	H	27	−27.836	1.322	1.182	1.00	27.70	B	N
  ATOM	3659	C	ASN	H	27	−24.507	0.652	2.619	1.00	18.42	B	C
  ATOM	3660	O	ASN	H	27	−24.904	0.783	1.462	1.00	18.47	B	O
  ATOM	3661	N	ILE	H	28	−23.291	0.196	2.907	1.00	16.54	B	N
  ATOM	3662	CA	ILE	H	28	−22.439	−0.335	1.849	1.00	14.59	B	C
  ATOM	3663	CB	ILE	H	28	−20.939	−0.378	2.223	1.00	14.01	B	C
  ATOM	3664	CG1	ILE	H	28	−20.746	−0.823	3.674	1.00	15.60	B	C
  ATOM	3665	CD1	ILE	H	28	−20.221	−2.240	3.815	1.00	16.26	B	C
  ATOM	3666	CG2	ILE	H	28	−20.276	0.964	1.942	1.00	12.57	B	C
  ATOM	3667	C	ILE	H	28	−22.898	−1.700	1.360	1.00	13.86	B	C
  ATOM	3668	O	ILE	H	28	−23.458	−2.494	2.119	1.00	13.70	B	O
  ATOM	3669	N	THR	H	29	−22.868	−1.850	0.044	1.00	13.23	B	N
  ATOM	3670	CA	THR	H	29	−23.353	−3.045	−0.612	1.00	12.65	B	C
  ATOM	3671	CB	THR	H	29	−24.751	−2.816	−1.206	1.00	12.69	B	C
  ATOM	3672	OG1	THR	H	29	−25.331	−1.643	−0.623	1.00	12.62	B	O
  ATOM	3673	CG2	THR	H	29	−25.650	−4.012	−0.934	1.00	12.92	B	C
  ATOM	3674	C	THR	H	29	−22.392	−3.355	−1.741	1.00	12.47	B	C
  ATOM	3675	O	THR	H	29	−21.760	−2.457	−2.297	1.00	12.53	B	O
  ATOM	3676	N	GLU	H	30	−22.300	−4.626	−2.095	1.00	11.98	B	N
  ATOM	3677	CA	GLU	H	30	−21.668	−5.007	−3.338	1.00	11.68	B	C
  ATOM	3678	CB	GLU	H	30	−20.393	−5.803	−3.049	1.00	11.98	B	C
  ATOM	3679	CG	GLU	H	30	−19.274	−5.593	−4.058	1.00	13.38	B	C
  ATOM	3680	CD	GLU	H	30	−17.927	−6.054	−3.533	1.00	16.03	B	C
  ATOM	3681	OE1	GLU	H	30	−17.846	−7.190	−3.019	1.00	16.65	B	O
  ATOM	3682	OE2	GLU	H	30	−16.968	−5.253	−3.563	1.00	17.06	B	O
  ATOM	3683	C	GLU	H	30	−22.655	−5.860	−4.114	1.00	11.39	B	C
  ATOM	3684	O	GLU	H	30	−23.316	−6.727	−3.542	1.00	11.50	B	O
  ATOM	3685	N	GLU	H	31	−22.850	−5.534	−5.384	1.00	11.11	B	N
  ATOM	3686	CA	GLU	H	31	−23.602	−6.419	−6.248	1.00	11.06	B	C
  ATOM	3687	CB	GLU	H	31	−24.955	−5.813	−6.611	1.00	11.48	B	C
  ATOM	3688	CG	GLU	H	31	−25.093	−5.417	−8.063	1.00	13.90	B	C
  ATOM	3689	CD	GLU	H	31	−26.500	−4.981	−8.404	1.00	17.27	B	C
  ATOM	3690	OE1	GLU	H	31	−27.092	−5.567	−9.335	1.00	17.55	B	O
  ATOM	3691	OE2	GLU	H	31	−27.053	−4.130	−7.676	1.00	18.73	B	O
  ATOM	3692	C	GLU	H	31	−22.828	−6.839	−7.485	1.00	10.47	B	C
  ATOM	3693	O	GLU	H	31	−22.042	−6.071	−8.040	1.00	10.12	B	O
  ATOM	3694	N	PHE	H	32	−22.962	−8.116	−7.818	1.00	10.15	B	N
  ATOM	3695	CA	PHE	H	32	−22.042	−8.788	−8.716	1.00	9.62	B	C
  ATOM	3696	CB	PHE	H	32	−21.692	−10.167	−8.158	1.00	9.42	B	C
  ATOM	3697	CG	PHE	H	32	−21.130	−11.106	−9.179	1.00	9.27	B	C
  ATOM	3698	CD1	PHE	H	32	−19.865	−10.896	−9.702	1.00	9.37	B	C
  ATOM	3699	CE1	PHE	H	32	−19.315	−11.784	−10.605	1.00	9.52	B	C
  ATOM	3700	CZ	PHE	H	32	−20.027	−12.905	−10.989	1.00	9.82	B	C
  ATOM	3701	CE2	PHE	H	32	−21.294	−13.127	−10.472	1.00	10.13	B	C
  ATOM	3702	CD2	PHE	H	32	−21.822	−12.250	−9.544	1.00	10.06	B	C
  ATOM	3703	C	PHE	H	32	−22.707	−8.941	−10.074	1.00	9.64	B	C
  ATOM	3704	O	PHE	H	32	−23.887	−9.282	−10.159	1.00	9.84	B	O
  ATOM	3705	N	TYR	H	33	−21.965	−8.638	−11.132	1.00	9.59	B	N
  ATOM	3706	CA	TYR	H	33	−22.526	−8.672	−12.474	1.00	9.67	B	C
  ATOM	3707	CB	TYR	H	33	−22.259	−7.360	−13.207	1.00	9.52	B	C
  ATOM	3708	CG	TYR	H		33	−23.038	−6.196	−12.645	1.00	10.94	B	C
  ATOM	3709	CD1	TYR	H	33	−22.482	−5.372	−11.677	1.00	12.23	B	C
  ATOM	3710	CE1	TYR	H	33	−23.198	−4.323	−11.137	1.00	12.93	B	C
  ATOM	3711	CZ	TYR	H	33	−24.510	−4.129	−11.510	1.00	13.47	B	C
  ATOM	3712	OH	TYR	H		33	−25.231	−3.093	−10.963	1.00	14.54	B	O
  ATOM	3713	CE2	TYR	H	33	−25.100	−4.963	−12.436	1.00	13.56	B	C
  ATOM	3714	CD2	TYR	H	33	−24.373	−6.006	−12.976	1.00	12.96	B	C
  ATOM	3715	C	TYR	H	33	−22.001	−9.853	−13.273	1.00	9.94	B	C
  ATOM	3716	O	TYR	H	33	−20.998	−9.747	−13.978	1.00	10.16	B	O
  ATOM	3717	N	GLN	H	34	−22.714	−10.969	−13.184	1.00	10.06	B	N
  ATOM	3718	CA	GLN	H	34	−22.191	−12.249	−13.632	1.00	10.01	B	C
  ATOM	3719	CB	GLN	H	34	−23.190	−13.361	−13.327	1.00	10.22	B	C
  ATOM	3720	CG	GLN	H	34	−22.760	−14.720	−13.829	1.00	11.12	B	C
  ATOM	3721	CD	GLN	H	34	−23.604	−15.836	−13.257	1.00	13.13	B	C
  ATOM	3722	OE1	GLN	H	34	−24.746	−16.042	−13.673	1.00	14.24	B	O
  ATOM	3723	NE2	GLN	H	34	−23.057	−16.550	−12.278	1.00	13.79	B	N
  ATOM	3724	C	GLN	H	34	−21.889	−12.220	−15.123	1.00	9.94	B	C
  ATOM	3725	O	GLN	H	34	−21.096	−13.018	−15.622	1.00	10.08	B	O
  ATOM	3726	N	SER	H	35	−22.564	−11.324	−15.836	1.00	9.87	B	N
  ATOM	3727	CA	SER	H	35	−22.458	−11.253	−17.290	1.00	9.91	B	C
  ATOM	3728	CB	SER	H	35	−23.743	−10.676	−17.889	1.00	10.03	B	C
  ATOM	3729	OG	SER	H	35	−24.034	−9.401	−17.343	1.00	10.81	B	O
  ATOM	3730	C	SER	H	35	−21.256	−10.410	−17.713	1.00	9.56	B	C
  ATOM	3731	O	SER	H	35	−21.002	−10.214	−18.903	1.00	9.59	B	O
  ATOM	3732	N	THR	H	36	−20.539	−9.892	−16.724	1.00	9.21	B	N
  ATOM	3733	CA	THR	H	36	−19.420	−8.996	−16.964	1.00	9.06	B	C
  ATOM	3734	CB	THR	H	36	−19.817	−7.536	−16.686	1.00	9.49	B	C
  ATOM	3735	OG1	THR	H	36	−20.874	−7.149	−17.573	1.00	10.82	B	O
  ATOM	3736	CG2	THR	H		36	−18.629	−6.609	−16.883	1.00	9.45	B	C
  ATOM	3737	C	THR	H	36	−18.292	−9.403	−16.029	1.00	8.77	B	C
  ATOM	3738	O	THR	H	36	−17.298	−8.693	−15.882	1.00	8.60	B	O
  ATOM	3739	N	CYS	H	37	−18.457	−10.572	−15.415	1.00	8.69	B	N
  ATOM	3740	CA	CYS	H	37	−17.594	−11.011	−14.327	1.00	8.69	B	C
  ATOM	3741	CB	CYS	H	37	−16.509	−11.955	−14.846	1.00	8.81	B	C
  ATOM	3742	SG	CYS	H	37	−15.737	−12.977	−13.569	1.00	10.80	B	S
  ATOM	3743	C	CYS	H	37	−16.958	−9.820	−13.631	1.00	8.27	B	C
  ATOM	3744	O	CYS	H	37	−15.735	−9.671	−13.628	1.00	8.27	B	O
  ATOM	3745	N	SER	H	38	−17.796	−8.950	−13.080	1.00	7.92	B	N
  ATOM	3746	CA	SER	H	38	−17.309	−7.784	−12.360	1.00	7.51	B	C
  ATOM	3747	CB	SER	H	38	−17.130	−6.595	−13.308	1.00	7.63	B	C
  ATOM	3748	OG	SER	H	38	−18.369	−6.193	−13.864	1.00	8.54	B	O
  ATOM	3749	C	SER	H	38	−18.227	−7.411	−11.207	1.00	7.02	B	C
  ATOM	3750	O	SER	H	38	−19.404	−7.771	−11.192	1.00	6.83	B	O
  ATOM	3751	N	ALA	H	39	−17.647	−6.784	−10.191	1.00	6.64	B	N
  ATOM	3752	CA	ALA	H	39	−18.371	−6.478	−8.969	1.00	6.58	B	C
  ATOM	3753	CB	ALA	H	39	−17.843	−7.320	−7.817	1.00	6.67	B	C
  ATOM	3754	C	ALA	H	39	−18.242	−4.995	−8.651	1.00	6.93	B	C
  ATOM	3755	O	ALA	H	39	−17.217	−4.378	−8.944	1.00	7.38	B	O
  ATOM	3756	N	VAL	H		40	−19.333	−4.401	−8.179	1.00	6.87	B	N
  ATOM	3757	CA	VAL	H		40	−19.316	−3.008	−7.746	1.00	6.55	B	C
  ATOM	3758	CB	VAL	H	40	−20.208	−2.122	−8.635	1.00	6.22	B	C
  ATOM	3759	CG1	VAL	H		40	−20.465	−0.783	−7.959	1.00	6.52	B	C
  ATOM	3760	CG2	VAL	H		40	−19.564	−1.921	−9.998	1.00	6.62	B	C
  ATOM	3761	C	VAL	H		40	−19.743	−2.862	−6.290	1.00	6.73	B	C
  ATOM	3762	O	VAL	H		40	−20.805	−3.340	−5.891	1.00	6.83	B	O
  ATOM	3763	N	SER	H	41	−18.883	−2.240	−5.492	1.00	6.86	B	N
  ATOM	3764	CA	SER	H	41	−19.251	−1.825	−4.148	1.00	6.75	B	C
  ATOM	3765	CB	SER	H	41	−18.020	−1.779	−3.242	1.00	7.06	B	C
  ATOM	3766	OG	SER	H	41	−16.905	−2.388	−3.866	1.00	7.50	B	O
  ATOM	3767	C	SER	H	41	−19.922	−0.461	−4.180	1.00	6.56	B	C
  ATOM	3768	O	SER	H	41	−19.392	0.490	−4.756	1.00	6.08	B	O
  ATOM	3769	N	LYS	H	42	−21.097	−0.378	−3.565	1.00	7.02	B	N
  ATOM	3770	CA	LYS	H	42	−21.938	0.810	−3.662	1.00	7.83	B	C
  ATOM	3771	CB	LYS	H	42	−23.296	0.459	−4.269	1.00	8.15	B	C
  ATOM	3772	CG	LYS	H	42	−23.226	−0.171	−5.641	1.00	9.75	B	C
  ATOM	3773	CD	LYS	H	42	−24.621	−0.473	−6.153	1.00	12.62	B	C
  ATOM	3774	CE	LYS	H	42	−24.579	−1.069	−7.548	1.00	14.04	B	C
  ATOM	3775	NZ	LYS	H	42	−25.858	−0.856	−8.279	1.00	14.96	B	N
  ATOM	3776	C	LYS	H	42	−22.143	1.444	−2.290	1.00	7.80	B	C
  ATOM	3777	O	LYS	H	42	−21.947	0.798	−1.258	1.00	8.15	B	O
  ATOM	3778	N	GLY	H	43	−22.594	2.696	−2.290	1.00	7.59	B	N
  ATOM	3779	CA	GLY	H	43	−23.140	3.321	−1.090	1.00	7.35	B	C
  ATOM	3780	C	GLY	H	43	−22.131	4.200	−0.378	1.00	7.10	B	C
  ATOM	3781	O	GLY	H	43	−22.239	4.439	0.824	1.00	7.13	B	O
  ATOM	3782	N	TYR	H	44	−21.173	4.723	−1.136	1.00	7.01	B	N
  ATOM	3783	CA	TYR	H	44	−20.106	5.549	−0.577	1.00	6.89	B	C
  ATOM	3784	CB	TYR	H	44	−18.755	5.125	−1.160	1.00	6.88	B	C
  ATOM	3785	CG	TYR	H	44	−18.296	3.748	−0.732	1.00	6.41	B	C
  ATOM	3786	CD1	TYR	H	44	−18.340	2.676	−1.615	1.00	6.62	B	C
  ATOM	3787	CE1	TYR	H	44	−17.871	1.427	−1.245	1.00	6.48	B	C
  ATOM	3788	CZ	TYR	H	44	−17.312	1.253	0.005	1.00	6.88	B	C
  ATOM	3789	OH	TYR	H	44	−16.834	0.020	0.386	1.00	7.50	B	O
  ATOM	3790	CE2	TYR	H	44	−17.197	2.318	0.870	1.00	6.68	B	C
  ATOM	3791	CD2	TYR	H	44	−17.670	3.559	0.492	1.00	5.91	B	C
  ATOM	3792	C	TYR	H	44	−20.357	7.026	−0.886	1.00	6.86	B	C
  ATOM	3793	O	TYR	H	44	−20.912	7.354	−1.933	1.00	7.14	B	O
  ATOM	3794	N	LEU	H	45	−19.834	7.916	−0.045	1.00	6.44	B	N
  ATOM	3795	CA	LEU	H	45	−20.073	9.356	−0.205	1.00	6.12	B	C
  ATOM	3796	CB	LEU	H	45	−20.896	9.917	0.966	1.00	6.31	B	C
  ATOM	3797	CG	LEU	H	45	−22.355	9.463	1.108	1.00	6.38	B	C
  ATOM	3798	CD1	LEU	H	45	−22.859	9.699	2.524	1.00	7.05	B	C
  ATOM	3799	CD2	LEU	H	45	−23.256	10.158	0.096	1.00	7.05	B	C
  ATOM	3800	C	LEU	H	45	−18.791	10.173	−0.413	1.00	5.84	B	C
  ATOM	3801	O	LEU	H	45	−17.966	10.289	0.493	1.00	5.94	B	O
  ATOM	3802	N	SER	H	46	−18.764	10.924	−1.512	1.00	5.43	B	N
  ATOM	3803	CA	SER	H	46	−17.528	11.442	−2.112	1.00	5.26	B	C
  ATOM	3804	CB	SER	H	46	−17.801	11.821	−3.568	1.00	5.21	B	C
  ATOM	3805	OG	SER	H	46	−18.827	12.800	−3.647	1.00	4.95	B	O
  ATOM	3806	C	SER	H	46	−17.113	12.696	−1.355	1.00	5.51	B	C
  ATOM	3807	O	SER	H	46	−17.968	13.359	−0.771	1.00	6.03	B	O
  ATOM	3808	N	ALA	H	47	−15.850	13.103	−1.424	1.00	5.24	B	N
  ATOM	3809	CA	ALA	H	47	−15.530	14.323	−0.704	1.00	4.83	B	C
  ATOM	3810	CB	ALA	H	47	−16.269	14.344	0.622	1.00	5.01	B	C
  ATOM	3811	C	ALA	H	47	−14.089	14.763	−0.512	1.00	4.35	B	C
  ATOM	3812	O	ALA	H	47	−13.178	13.936	−0.449	1.00	4.45	B	O
  ATOM	3813	N	LEU	H	48	−13.989	15.994	−0.016	1.00	3.67	B	N
  ATOM	3814	CA	LEU	H	48	−12.719	16.625	0.308	1.00	3.15	B	C
  ATOM	3815	CB	LEU	H	48	−12.390	17.712	−0.720	1.00	2.78	B	C
  ATOM	3816	CG	LEU	H	48	−12.856	17.464	−2.159	1.00	2.18	B	C
  ATOM	3817	CD1	LEU	H	48	−12.396	18.583	−3.082	1.00	2.00	B	C
  ATOM	3818	CD2	LEU	H	48	−12.378	16.109	−2.666	1.00	3.94	B	C
  ATOM	3819	C	LEU	H	48	−12.768	17.232	1.707	1.00	3.06	B	C
  ATOM	3820	O	LEU	H	48	−13.519	18.174	1.961	1.00	3.27	B	O
  ATOM	3821	N	ARG	H	49	−11.879	16.758	2.571	1.00	2.91	B	N
  ATOM	3822	CA	ARG	H	49	−11.733	17.305	3.912	1.00	2.88	B	C
  ATOM	3823	CB	ARG	H	49	−10.649	16.538	4.668	1.00	2.69	B	C
  ATOM	3824	CG	ARG	H	49	−11.032	16.140	6.075	1.00	2.15	B	C
  ATOM	3825	CD	ARG	H	49	−9.882	16.395	7.026	1.00	2.00	B	C
  ATOM	3826	NE	ARG	H	49	−9.728	17.816	7.320	1.00	5.18	B	N
  ATOM	3827	CZ	ARG	H	49	−8.580	18.478	7.231	1.00	7.68	B	C
  ATOM	3828	NH1	ARG	H	49	−7.481	17.849	6.838	1.00	8.32	B	N
  ATOM	3829	NH2	ARG	H	49	−8.521	19.756	7.575	1.00	8.12	B	N
  ATOM	3830	C	ARG	H	49	−11.364	18.780	3.843	1.00	3.09	B	C
  ATOM	3831	O	ARG	H	49	−10.497	19.175	3.064	1.00	3.08	B	O
  ATOM	3832	N	THR	H	50	−12.022	19.593	4.661	1.00	3.37	B	N
  ATOM	3833	CA	THR	H	50	−11.594	20.970	4.855	1.00	3.55	B	C
  ATOM	3834	CB	THR	H	50	−12.413	21.946	3.998	1.00	3.25	B	C
  ATOM	3835	OG1	THR	H	50	−13.807	21.633	4.109	1.00	2.66	B	O
  ATOM	3836	CG2	THR	H	50	−11.992	21.844	2.543	1.00	3.46	B	C
  ATOM	3837	C	THR	H	50	−11.665	21.395	6.313	1.00	4.07	B	C
  ATOM	3838	O	THR	H	50	−11.171	22.462	6.678	1.00	4.35	B	O
  ATOM	3840	CA	GLY	H	51	−13.255	22.675	6.821	1.00	4.78	B	C
  ATOM	3841	C	GLY	H	51	−11.930	22.228	7.407	1.00	4.98	B	C
  ATOM	3842	O	GLY	H	51	−11.589	21.046	7.365	1.00	5.00	B	O
  ATOM	3843	N	TRP	H	52	−11.162	23.180	7.925	1.00	5.34	B	N
  ATOM	3844	CA	TRP	H	52	−9.845	22.878	8.465	1.00	5.42	B	C
  ATOM	3845	CB	TRP	H	52	−8.754	23.540	7.632	1.00	5.75	B	C
  ATOM	3846	CG	TRP	H	52	−8.691	23.029	6.243	1.00	6.38	B	C
  ATOM	3847	CD1	TRP	H	52	−9.100	23.678	5.117	1.00	7.27	B	C
  ATOM	3848	NE1	TRP	H	52	−8.926	22.875	4.019	1.00	7.46	B	N
  ATOM	3849	CE2	TRP	H	52	−8.445	21.660	4.430	1.00	7.15	B	C
  ATOM	3850	CD2	TRP	H	52	−8.315	21.710	5.832	1.00	7.02	B	C
  ATOM	3851	CE3	TRP	H	52	−7.799	20.595	6.500	1.00	6.83	B	C
  ATOM	3852	CZ3	TRP	H	52	−7.466	19.473	5.761	1.00	6.73	B	C
  ATOM	3853	CH2	TRP	H	52	−7.634	19.445	4.372	1.00	7.13	B	C
  ATOM	3854	CZ2	TRP	H	52	−8.111	20.529	3.689	1.00	6.82	B	C
  ATOM	3855	C	TRP	H	52	−9.723	23.329	9.905	1.00	5.34	B	C
  ATOM	3856	O	TRP	H	52	−10.279	24.359	10.289	1.00	5.47	B	O
  ATOM	3857	N	TYR	H	53	−8.800	22.695	10.615	1.00	5.29	B	N
  ATOM	3858	CA	TYR	H	53	−8.531	23.038	11.997	1.00	5.58	B	C
  ATOM	3859	CB	TYR	H	53	−9.040	21.934	12.919	1.00	5.51	B	C
  ATOM	3860	CG	TYR	H	53	−8.759	22.187	14.377	1.00	6.59	B	C
  ATOM	3861	CD1	TYR	H	53	−9.668	22.879	15.169	1.00	8.25	B	C
  ATOM	3862	CE1	TYR	H	53	−9.440	23.068	16.521	1.00	9.40	B	C
  ATOM	3863	CZ	TYR	H	53	−8.293	22.555	17.096	1.00	9.24	B	C
  ATOM	3864	OH	TYR	H	53	−8.053	22.750	18.439	1.00	9.61	B	O
  ATOM	3865	CE2	TYR	H	53	−7.360	21.893	16.321	1.00	8.78	B	C
  ATOM	3866	CD2	TYR	H	53	−7.600	21.709	14.971	1.00	7.93	B	C
  ATOM	3867	C	TYR	H	53	−7.042	23.256	12.214	1.00	5.74	B	C
  ATOM	3868	O	TYR	H	53	−6.259	22.306	12.223	1.00	6.19	B	O
  ATOM	3869	N	THR	H	54	−6.645	24.521	12.296	1.00	6.04	B	N
  ATOM	3870	CA	THR	H	54	−5.249	24.869	12.519	1.00	6.67	B	C
  ATOM	3871	CB	THR	H	54	−5.032	26.391	12.438	1.00	6.97	B	C
  ATOM	3872	OG1	THR	H	54	−4.958	26.793	11.064	1.00	7.51	B	O
  ATOM	3873	CG2	THR	H	54	−3.747	26.788	13.147	1.00	7.98	B	C
  ATOM	3874	C	THR	H	54	−4.775	24.360	13.877	1.00	6.97	B	C
  ATOM	3875	O	THR	H	54	−5.576	24.173	14.792	1.00	7.32	B	O
  ATOM	3876	N	SER	H	55	−3.479	24.086	13.987	1.00	7.24	B	N
  ATOM	3877	CA	SER	H	55	−2.811	24.106	15.282	1.00	7.65	B	C
  ATOM	3878	CB	SER	H	55	−3.110	22.830	16.072	1.00	7.69	B	C
  ATOM	3879	OG	SER	H	55	−2.308	22.754	17.238	1.00	7.51	B	O
  ATOM	3880	C	SER	H	55	−1.308	24.309	15.154	1.00	8.03	B	C
  ATOM	3881	O	SER	H	55	−0.654	23.695	14.311	1.00	8.43	B	O
  ATOM	3882	N	VAL	H	56	−0.760	25.106	16.063	1.00	8.14	B	N
  ATOM	3883	CA	VAL	H	56	0.600	25.601	15.930	1.00	8.41	B	C
  ATOM	3884	CB	VAL	H	56	0.672	27.116	16.193	1.00	8.72	B	C
  ATOM	3885	CG1	VAL	H	56	1.868	27.723	15.477	1.00	9.29	B	C
  ATOM	3886	CG2	VAL	H	56	−0.619	27.792	15.756	1.00	9.51	B	C
  ATOM	3887	C	VAL	H	56	1.509	24.884	16.917	1.00	8.19	B	C
  ATOM	3888	O	VAL	H	56	1.348	25.011	18.129	1.00	8.54	B	O
  ATOM	3889	N	ILE	H	57	2.428	24.086	16.389	1.00	7.91	B	N
  ATOM	3890	CA	ILE	H	57	3.224	23.192	17.214	1.00	7.64	B	C
  ATOM	3891	CB	ILE	H	57	3.175	21.749	16.674	1.00	7.35	B	C
  ATOM	3892	CG1	ILE	H	57	1.726	21.302	16.462	1.00	7.25	B	C
  ATOM	3893	CD1	ILE	H	57	1.593	19.930	15.834	1.00	8.42	B	C
  ATOM	3894	CG2	ILE	H	57	3.915	20.799	17.603	1.00	7.52	B	C
  ATOM	3895	C	ILE	H	57	4.670	23.670	17.258	1.00	7.69	B	C
  ATOM	3896	O	ILE	H	57	5.272	23.936	16.219	1.00	7.79	B	O
  ATOM	3897	N	THR	H	58	5.175	23.897	18.467	1.00	7.85	B	N
  ATOM	3898	CA	THR	H	58	6.465	24.554	18.659	1.00	8.15	B	C
  ATOM	3899	CB	THR	H	58	6.297	25.903	19.383	1.00	8.14	B	C
  ATOM	3900	OG1	THR	H	58	4.946	26.360	19.239	1.00	8.62	B	O
  ATOM	3901	CG2	THR	H	58	7.246	26.943	18.806	1.00	7.94	B	C
  ATOM	3902	C	THR	H	58	7.393	23.666	19.485	1.00	8.20	B	C
  ATOM	3903	O	THR	H	58	7.051	23.281	20.600	1.00	8.18	B	O
  ATOM	3904	N	ILE	H	59	8.565	23.351	18.941	1.00	8.54	B	N
  ATOM	3905	CA	ILE	H	59	9.482	22.397	19.572	1.00	9.23	B	C
  ATOM	3906	CB	ILE	H	59	9.604	21.112	18.729	1.00	8.92	B	C
  ATOM	3907	CG1	ILE	H	59	8.231	20.482	18.496	1.00	9.27	B	C
  ATOM	3908	CD1	ILE	H	59	8.253	19.315	17.533	1.00	10.89	B	C
  ATOM	3909	CG2	ILE	H	59	10.559	20.130	19.387	1.00	8.74	B	C
  ATOM	3910	C	ILE	H	59	10.880	23.004	19.691	1.00	10.02	B	C
  ATOM	3911	O	ILE	H	59	11.474	23.380	18.684	1.00	10.20	B	O
  ATOM	3912	N	GLU	H	60	11.434	23.059	20.898	1.00	10.95	B	N
  ATOM	3913	CA	GLU	H	60	12.592	23.923	21.138	1.00	12.13	B	C
  ATOM	3914	CB	GLU	H	60	12.914	23.976	22.634	1.00	12.44	B	C
  ATOM	3915	CG	GLU	H	60	11.854	24.705	23.444	1.00	15.04	B	C
  ATOM	3916	CD	GLU	H	60	12.365	25.173	24.793	1.00	19.34	B	C
  ATOM	3917	OE1	GLU	H	60	12.659	24.309	25.647	1.00	20.63	B	O
  ATOM	3918	OE2	GLU	H	60	12.495	26.401	24.990	1.00	21.19	B	O
  ATOM	3919	C	GLU	H	60	13.816	23.509	20.301	1.00	12.46	B	C
  ATOM	3920	O	GLU	H	60	14.196	22.336	20.316	1.00	12.68	B	O
  ATOM	3921	N	LEU	H	61	14.390	24.428	19.510	1.00	12.80	B	N
  ATOM	3922	CA	LEU	H	61	15.786	24.207	19.132	1.00	12.71	B	C
  ATOM	3923	CB	LEU	H	61	16.470	25.295	18.316	1.00	12.55	B	C
  ATOM	3924	CG	LEU	H	61	17.932	24.803	18.355	1.00	12.39	B	C
  ATOM	3925	CD1	LEU	H	61	18.053	23.370	17.848	1.00	13.14	B	C
  ATOM	3926	CD2	LEU	H	61	18.944	25.717	17.683	1.00	12.50	B	C
  ATOM	3927	C	LEU	H	61	16.459	24.114	20.455	1.00	12.94	B	C
  ATOM	3928	O	LEU	H	61	16.827	25.135	21.048	1.00	12.78	B	O
  ATOM	3929	N	SER	H	62	16.080	23.014	21.081	1.00	13.61	B	N
  ATOM	3930	CA	SER	H	62	16.441	22.760	22.447	1.00	14.70	B	C
  ATOM	3931	CB	SER	H	62	15.805	21.454	22.924	1.00	14.52	B	C
  ATOM	3932	OG	SER	H	62	14.398	21.584	23.034	1.00	14.80	B	O
  ATOM	3933	C	SER	H	62	17.947	22.650	22.469	1.00	15.48	B	C
  ATOM	3934	O	SER	H	62	18.498	21.677	21.961	1.00	15.50	B	O
  ATOM	3935	N	ASN	H	63	18.597	23.777	22.721	1.00	16.61	B	N
  ATOM	3936	CA	ASN	H	63	20.030	23.839	22.523	1.00	17.77	B	C
  ATOM	3937	CB	ASN	H	63	20.519	25.279	22.439	1.00	17.73	B	C
  ATOM	3938	CG	ASN	H	63	21.686	25.433	21.493	1.00	18.52	B	C
  ATOM	3939	OD1	ASN	H	63	22.559	24.567	21.428	1.00	18.29	B	O
  ATOM	3940	ND2	ASN	H	63	21.641	26.467	20.665	1.00	19.40	B	N
  ATOM	3941	C	ASN	H	63	20.795	23.070	23.587	1.00	18.53	B	C
  ATOM	3942	O	ASN	H	63	20.356	22.967	24.732	1.00	18.82	B	O
  ATOM	3943	N	ILE	H	64	21.887	22.440	23.169	1.00	19.60	B	N
  ATOM	3944	CA	ILE	H	64	22.830	21.832	24.096	1.00	21.04	B	C
  ATOM	3945	CB	ILE	H	64	23.599	20.680	23.429	1.00	20.60	B	C
  ATOM	3946	CG1	ILE	H	64	22.650	19.824	22.590	1.00	20.13	B	C
  ATOM	3947	CD1	ILE	H	64	23.355	18.820	21.712	1.00	20.19	B	C
  ATOM	3948	CG2	ILE	H	64	24.321	19.843	24.474	1.00	20.74	B	C
  ATOM	3949	C	ILE	H	64	23.837	22.859	24.601	1.00	22.58	B	C
  ATOM	3950	O	ILE	H	64	24.450	23.577	23.811	1.00	23.07	B	O
  ATOM	3951	N	LYS	H	65	24.104	22.827	25.903	1.00	24.21	B	N
  ATOM	3952	CA	LYS	H	65	25.356	23.354	26.435	1.00	25.86	B	C
  ATOM	3953	CB	LYS	H	65	25.109	24.202	27.686	1.00	25.90	B	C
  ATOM	3954	CG	LYS	H	65	23.736	24.015	28.312	1.00	26.69	B	C
  ATOM	3955	CD	LYS	H	65	23.556	22.597	28.830	1.00	28.26	B	C
  ATOM	3956	CE	LYS	H	65	23.104	22.591	30.281	1.00	28.67	B	C
  ATOM	3957	NZ	LYS	H	65	23.397	21.291	30.946	1.00	28.95	B	N
  ATOM	3958	C	LYS	H	65	26.377	22.252	26.719	1.00	26.81	B	C
  ATOM	3959	O	LYS	H	65	26.297	21.561	27.736	1.00	26.72	B	O
  ATOM	3960	N	GLU	H	66	27.382	22.159	25.852	1.00	27.90	B	N
  ATOM	3961	CA	GLU	H	66	28.276	21.001	25.793	1.00	28.82	B	C
  ATOM	3962	CB	GLU	H	66	29.031	20.991	24.457	1.00	28.88	B	C
  ATOM	3963	CG	GLU	H	66	30.531	20.737	24.572	1.00	30.33	B	C
  ATOM	3964	CD	GLU	H	66	31.320	21.283	23.391	1.00	33.17	B	C
  ATOM	3965	OE1	GLU	H	66	32.446	20.796	23.151	1.00	35.05	B	O
  ATOM	3966	OE2	GLU	H	66	30.864	22.268	22.775	1.00	33.14	B	O
  ATOM	3967	C	GLU	H	66	29.267	21.029	26.954	1.00	29.12	B	C
  ATOM	3968	O	GLU	H	66	29.751	22.097	27.329	1.00	29.28	B	O
  ATOM	3969	N	ASN	H	67	29.545	19.871	27.547	1.00	29.32	B	N
  ATOM	3970	CA	ASN	H	67	30.326	19.847	28.783	1.00	29.39	B	C
  ATOM	3971	CB	ASN	H	67	29.525	19.250	29.941	1.00	29.62	B	C
  ATOM	3972	CG	ASN	H	67	28.892	20.317	30.814	1.00	29.84	B	C
  ATOM	3973	OD1	ASN	H	67	29.589	21.032	31.534	1.00	29.93	B	O
  ATOM	3974	ND2	ASN	H	67	27.597	20.540	30.625	1.00	29.22	B	N
  ATOM	3975	C	ASN	H	67	31.745	19.271	28.698	1.00	29.15	B	C
  ATOM	3976	O	ASN	H	67	31.977	18.111	29.044	1.00	29.06	B	O
  ATOM	3977	N	LYS	H	68	32.625	20.020	28.036	1.00	28.87	B	N
  ATOM	3978	CA	LYS	H	68	34.033	20.170	28.428	1.00	28.78	B	C
  ATOM	3979	CB	LYS	H	68	34.334	21.625	28.806	1.00	28.89	B	C
  ATOM	3980	CG	LYS	H	68	33.742	22.653	27.846	1.00	29.26	B	C
  ATOM	3981	CD	LYS	H	68	33.794	24.057	28.427	1.00	29.68	B	C
  ATOM	3982	CE	LYS	H	68	35.058	24.267	29.243	1.00	29.46	B	C
  ATOM	3983	NZ	LYS	H	68	35.195	25.675	29.705	1.00	29.58	B	N
  ATOM	3984	C	LYS	H	68	34.543	19.202	29.509	1.00	28.60	B	C
  ATOM	3985	O	LYS	H	68	34.879	19.622	30.618	1.00	28.64	B	O
  ATOM	3986	N	CYS	H	69	34.618	17.912	29.162	1.00	28.09	B	N
  ATOM	3987	CA	CYS	H	69	35.404	16.889	29.895	1.00	27.63	B	C
  ATOM	3988	CB	CYS	H	69	34.502	15.694	30.287	1.00	27.07	B	C
  ATOM	3989	SG	CYS	H	69	34.515	14.237	29.134	1.00	28.01	B	S
  ATOM	3990	C	CYS	H	69	36.550	16.388	29.003	1.00	27.69	B	C
  ATOM	3991	O	CYS	H	69	36.474	16.529	27.785	1.00	27.41	B	O
  ATOM	3992	N	ASN	H	70	37.563	15.732	29.576	1.00	28.06	B	N
  ATOM	3993	CA	ASN	H	70	38.498	14.929	28.760	1.00	28.87	B	C
  ATOM	3994	CB	ASN	H	70	39.930	15.507	28.746	1.00	30.52	B	C
  ATOM	3995	CG	ASN	H	70	40.024	16.921	29.323	1.00	39.60	B	C
  ATOM	3996	OD1	ASN	H	70	39.691	17.905	28.661	1.00	44.97	B	O
  ATOM	3997	ND2	ASN	H	70	40.562	17.019	30.542	1.00	51.04	B	N
  ATOM	3998	C	ASN	H	70	38.528	13.423	29.067	1.00	26.97	B	C
  ATOM	3999	O	ASN	H	70	39.060	13.009	30.096	1.00	26.50	B	O
  ATOM	4000	N	GLY	H	71	38.111	12.611	28.096	1.00	25.46	B	N
  ATOM	4001	CA	GLY	H	71	38.117	11.148	28.237	1.00	23.67	B	C
  ATOM	4002	C	GLY	H	71	39.357	10.485	27.657	1.00	22.81	B	C
  ATOM	4003	O	GLY	H	71	40.279	11.169	27.211	1.00	22.79	B	O
  ATOM	4004	N	THR	H	72	39.400	9.155	27.687	1.00	21.93	B	N
  ATOM	4005	CA	THR	H	72	40.517	8.418	27.100	1.00	21.30	B	C
  ATOM	4006	CB	THR	H	72	40.594	6.975	27.644	1.00	21.12	B	C
  ATOM	4007	OG1	THR	H	72	39.700	6.131	26.909	1.00	19.87	B	O
  ATOM	4008	CG2	THR	H	72	40.210	6.947	29.115	1.00	20.76	B	C
  ATOM	4009	C	THR	H	72	40.436	8.407	25.571	1.00	21.50	B	C
  ATOM	4010	O	THR	H	72	39.458	7.924	24.999	1.00	21.85	B	O
  ATOM	4011	N	ASP	H	73	41.391	9.077	24.927	1.00	21.43	B	N
  ATOM	4012	CA	ASP	H	73	41.246	9.509	23.534	1.00	21.46	B	C
  ATOM	4013	CB	ASP	H	73	41.137	8.304	22.598	1.00	21.69	B	C
  ATOM	4014	CG	ASP	H	73	40.965	8.708	21.150	1.00	22.46	B	C
  ATOM	4015	OD1	ASP	H	73	40.678	9.896	20.894	1.00	23.01	B	O
  ATOM	4016	OD2	ASP	H	73	41.102	7.835	20.269	1.00	23.09	B	O
  ATOM	4017	C	ASP	H	73	40.060	10.451	23.324	1.00	20.96	B	C
  ATOM	4018	O	ASP	H	73	38.909	10.066	23.530	1.00	20.61	B	O
  ATOM	4019	N	ALA	H	74	40.342	11.642	22.802	1.00	20.42	B	N
  ATOM	4020	CA	ALA	H	74	39.342	12.698	22.730	1.00	20.38	B	C
  ATOM	4021	CB	ALA	H	74	39.707	13.839	23.670	1.00	20.11	B	C
  ATOM	4022	C	ALA	H	74	39.133	13.223	21.310	1.00	20.45	B	C
  ATOM	4023	O	ALA	H	74	38.545	14.286	21.121	1.00	20.46	B	O
  ATOM	4024	N	LYS	H	75	39.659	12.513	20.318	1.00	20.67	B	N
  ATOM	4025	CA	LYS	H	75	39.416	12.887	18.929	1.00	20.99	B	C
  ATOM	4026	CB	LYS	H	75	40.195	11.977	17.978	1.00	21.20	B	C
  ATOM	4027	CG	LYS	H	75	41.704	12.110	18.091	1.00	22.02	B	C
  ATOM	4028	CD	LYS	H	75	42.349	10.782	18.451	1.00	23.66	B	C
  ATOM	4029	CE	LYS	H	75	43.483	10.971	19.447	1.00	24.93	B	C
  ATOM	4030	NZ	LYS	H	75	43.559	9.859	20.434	1.00	25.55	B	N
  ATOM	4031	C	LYS	H	75	37.925	12.790	18.645	1.00	20.92	B	C
  ATOM	4032	O	LYS	H	75	37.397	13.474	17.768	1.00	20.92	B	O
  ATOM	4033	N	VAL	H	76	37.265	11.904	19.382	1.00	20.63	B	N
  ATOM	4034	CA	VAL	H	76	35.813	11.844	19.414	1.00	20.36	B	C
  ATOM	4035	CB	VAL	H	76	35.326	10.521	20.029	1.00	20.25	B	C
  ATOM	4036	CG1	VAL	H	76	33.817	10.537	20.157	1.00	20.82	B	C
  ATOM	4037	CG2	VAL	H	76	35.769	9.341	19.175	1.00	20.09	B	C
  ATOM	4038	C	VAL	H	76	35.234	13.006	20.213	1.00	20.29	B	C
  ATOM	4039	O	VAL	H	76	35.629	13.244	21.356	1.00	20.21	B	O
  ATOM	4040	N	LYS	H	77	34.284	13.715	19.613	1.00	20.17	B	N
  ATOM	4041	CA	LYS	H	77	33.726	14.916	20.224	1.00	20.17	B	C
  ATOM	4042	CB	LYS	H	77	34.593	16.136	19.904	1.00	20.62	B	C
  ATOM	4043	CG	LYS	H	77	35.797	16.307	20.825	1.00	23.31	B	C
  ATOM	4044	CD	LYS	H	77	36.952	16.989	20.103	1.00	26.74	B	C
  ATOM	4045	CE	LYS	H	77	38.196	17.046	20.971	1.00	28.32	B	C
  ATOM	4046	NZ	LYS	H	77	39.203	18.004	20.436	1.00	29.66	B	N
  ATOM	4047	C	LYS	H	77	32.294	15.141	19.759	1.00	19.45	B	C
  ATOM	4048	O	LYS	H	77	31.971	16.170	19.165	1.00	19.36	B	O
  ATOM	4049	N	LEU	H	78	31.441	14.162	20.033	1.00	18.70	B	N
  ATOM	4050	CA	LEU	H	78	30.155	14.056	19.365	1.00	17.98	B	C
  ATOM	4051	CB	LEU	H	78	29.356	12.892	19.945	1.00	17.72	B	C
  ATOM	4052	CG	LEU	H	78	30.168	11.596	20.034	1.00	17.51	B	C
  ATOM	4053	CD1	LEU	H	78	29.321	10.446	20.554	1.00	17.41	B	C
  ATOM	4054	CD2	LEU	H	78	30.802	11.249	18.690	1.00	17.62	B	C
  ATOM	4055	C	LEU	H	78	29.354	15.355	19.422	1.00	17.77	B	C
  ATOM	4056	O	LEU	H	78	28.996	15.911	18.384	1.00	17.89	B	O
  ATOM	4057	N	ILE	H	79	29.145	15.882	20.624	1.00	17.29	B	N
  ATOM	4058	CA	ILE	H	79	28.336	17.086	20.778	1.00	17.00	B	C
  ATOM	4059	CB	ILE	H	79	28.194	17.527	22.256	1.00	16.96	B	C
  ATOM	4060	CG1	ILE	H	79	27.588	16.401	23.098	1.00	17.21	B	C
  ATOM	4061	CD1	ILE	H	79	27.086	16.855	24.459	1.00	17.51	B	C
  ATOM	4062	CG2	ILE	H	79	27.307	18.762	22.359	1.00	17.30	B	C
  ATOM	4063	C	ILE	H	79	28.854	18.238	19.911	1.00	16.83	B	C
  ATOM	4064	O	ILE	H	79	28.119	18.753	19.065	1.00	17.02	B	O
  ATOM	4065	N	LYS	H	80	30.124	18.571	19.800	1.00	16.55	B	N
  ATOM	4066	CA	LYS	H	80	30.366	19.684	18.841	1.00	16.38	B	C
  ATOM	4067	CB	LYS	H	80	31.861	20.021	18.833	1.00	16.73	B	C
  ATOM	4068	CG	LYS	H	80	32.255	21.150	17.895	1.00	17.99	B	C
  ATOM	4069	CD	LYS	H	80	32.343	22.475	18.640	1.00	20.71	B	C
  ATOM	4070	CE	LYS	H	80	32.566	23.632	17.681	1.00	22.92	B	C
  ATOM	4071	NZ	LYS	H	80	31.339	23.929	16.886	1.00	24.75	B	N
  ATOM	4072	C	LYS	H	80	29.884	19.466	17.349	1.00	15.79	B	C
  ATOM	4073	O	LYS	H	80	29.216	20.348	16.717	1.00	15.32	B	O
  ATOM	4074	N	GLN	H	81	30.177	18.286	16.806	1.00	15.48	B	N
  ATOM	4075	CA	GLN	H	81	29.878	17.961	15.401	1.00	15.33	B	C
  ATOM	4076	CB	GLN	H	81	30.465	16.593	15.049	1.00	15.70	B	C
  ATOM	4077	CG	GLN	H	81	31.870	16.364	15.565	1.00	17.88	B	C
  ATOM	4078	CD	GLN	H	81	32.301	14.917	15.435	1.00	20.46	B	C
  ATOM	4079	OE1	GLN	H	81	31.670	14.133	14.730	1.00	21.59	B	O
  ATOM	4080	NE2	GLN	H	81	33.378	14.554	16.123	1.00	20.26	B	N
  ATOM	4081	C	GLN	H	81	28.388	17.966	15.047	1.00	14.63	B	C
  ATOM	4082	O	GLN	H	81	27.972	18.429	13.962	1.00	14.60	B	O
  ATOM	4083	N	GLU	H	82	27.589	17.434	15.964	1.00	13.81	B	N
  ATOM	4084	CA	GLU	H	82	26.157	17.373	15.759	1.00	13.37	B	C
  ATOM	4085	CB	GLU	H	82	25.479	16.677	16.938	1.00	13.20	B	C
  ATOM	4086	CG	GLU	H	82	25.315	15.176	16.781	1.00	15.04	B	C
  ATOM	4087	CD	GLU	H	82	24.344	14.824	15.669	1.00	17.51	B	C
  ATOM	4088	OE1	GLU	H	82	23.130	15.074	15.841	1.00	18.22	B	O
  ATOM	4089	OE2	GLU	H	82	24.789	14.286	14.632	1.00	17.87	B	O
  ATOM	4090	C	GLU	H	82	25.650	18.794	15.638	1.00	12.99	B	C
  ATOM	4091	O	GLU	H	82	24.834	19.102	14.767	1.00	12.89	B	O
  ATOM	4092	N	LEU	H	83	26.174	19.677	16.482	1.00	12.89	B	N
  ATOM	4093	CA	LEU	H	83	25.727	21.057	16.454	1.00	13.08	B	C
  ATOM	4094	CB	LEU	H	83	26.419	21.865	17.552	1.00	13.26	B	C
  ATOM	4095	CG	LEU	H		83	26.057	21.498	18.994	1.00	14.18	B	C
  ATOM	4096	CD1	LEU	H	83	26.535	22.566	19.968	1.00	15.11	B	C
  ATOM	4097	CD2	LEU	H	83	24.558	21.282	19.117	1.00	14.79	B	C
  ATOM	4098	C	LEU	H	83	26.032	21.656	15.092	1.00	13.18	B	C
  ATOM	4099	O	LEU	H	83	25.150	22.261	14.459	1.00	13.05	B	O
  ATOM	4100	N	ASP	H	84	27.239	21.416	14.581	1.00	13.56	B	N
  ATOM	4101	CA	ASP	H	84	27.527	21.999	13.258	1.00	14.15	B	C
  ATOM	4102	CB	ASP	H	84	28.982	21.729	12.856	1.00	14.80	B	C
  ATOM	4103	CG	ASP	H	84	29.949	21.873	14.018	1.00	18.26	B	C
  ATOM	4104	OD1	ASP	H	84	30.237	23.025	14.417	1.00	21.11	B	O
  ATOM	4105	OD2	ASP	H	84	30.439	20.837	14.522	1.00	22.12	B	O
  ATOM	4106	C	ASP	H	84	26.572	21.490	12.150	1.00	13.56	B	C
  ATOM	4107	O	ASP	H	84	26.023	22.286	11.326	1.00	13.70	B	O
  ATOM	4108	N	LYS	H	85	26.328	20.180	12.146	1.00	12.87	B	N
  ATOM	4109	CA	LYS	H	85	25.458	19.616	11.106	1.00	12.31	B	C
  ATOM	4110	CB	LYS	H	85	25.412	18.090	11.210	1.00	12.41	B	C
  ATOM	4111	CG	LYS	H	85	24.611	17.417	10.110	1.00	12.26	B	C
  ATOM	4112	CD	LYS	H	85	24.213	16.002	10.506	1.00	12.72	B	C
  ATOM	4113	CE	LYS	H	85	23.359	16.018	11.762	1.00	14.40	B	C
  ATOM	4114	NZ	LYS	H	85	22.929	14.654	12.180	1.00	16.45	B	N
  ATOM	4115	C	LYS	H	85	24.038	20.192	11.202	1.00	11.85	B	C
  ATOM	4116	O	LYS	H	85	23.384	20.522	10.179	1.00	11.66	B	O
  ATOM	4117	N	TYR	H	86	23.571	20.318	12.442	1.00	11.32	B	N
  ATOM	4118	CA	TYR	H	86	22.232	20.825	12.683	1.00	11.07	B	C
  ATOM	4119	CB	TYR	H	86	21.875	20.784	14.167	1.00	11.12	B	C
  ATOM	4120	CG	TYR	H	86	20.899	21.871	14.551	1.00	11.30	B	C
  ATOM	4121	CD1	TYR	H	86	19.564	21.805	14.169	1.00	12.16	B	C
  ATOM	4122	CE1	TYR	H	86	18.672	22.804	14.514	1.00	12.39	B	C
  ATOM	4123	CZ	TYR	H	86	19.106	23.886	15.243	1.00	12.62	B	C
  ATOM	4124	OH	TYR	H	86	18.218	24.880	15.587	1.00	12.72	B	O
  ATOM	4125	CE2	TYR	H	86	20.428	23.980	15.632	1.00	11.38	B	C
  ATOM	4126	CD2	TYR	H	86	21.315	22.979	15.284	1.00	11.05	B	C
  ATOM	4127	C	TYR	H	86	22.120	22.247	12.181	1.00	10.75	B	C
  ATOM	4128	O	TYR	H	86	21.114	22.622	11.573	1.00	10.45	B	O
  ATOM	4129	N	LYS	H	87	23.155	23.046	12.419	1.00	10.66	B	N
  ATOM	4130	CA	LYS	H	87	23.093	24.423	11.971	1.00	11.03	B	C
  ATOM	4131	CB	LYS	H	87	24.333	25.191	12.407	1.00	11.36	B	C
  ATOM	4132	CG	LYS	H	87	24.600	25.106	13.890	1.00	12.79	B	C
  ATOM	4133	CD	LYS	H	87	25.805	25.931	14.269	1.00	14.76	B	C
  ATOM	4134	CE	LYS	H	87	25.989	25.979	15.771	1.00	15.29	B	C
  ATOM	4135	NZ	LYS	H	87	27.137	26.849	16.138	1.00	16.27	B	N
  ATOM	4136	C	LYS	H	87	22.961	24.455	10.457	1.00	10.83	B	C
  ATOM	4137	O	LYS	H	87	22.122	25.189	9.920	1.00	11.11	B	O
  ATOM	4138	N	ASN	H	88	23.724	23.621	9.755	1.00	10.52	B	N
  ATOM	4139	CA	ASN	H	88	23.568	23.646	8.297	1.00	10.21	B	C
  ATOM	4140	CB	ASN	H	88	24.586	22.715	7.640	1.00	10.61	B	C
  ATOM	4141	CG	ASN	H	88	24.426	22.646	6.134	1.00	11.81	B	C
  ATOM	4142	OD1	ASN	H	88	24.215	23.664	5.474	1.00	12.97	B	O
  ATOM	4143	ND2	ASN	H	88	24.515	21.443	5.585	1.00	13.82	B	N
  ATOM	4144	C	ASN	H	88	22.142	23.279	7.825	1.00	9.42	B	C
  ATOM	4145	O	ASN	H	88	21.538	23.959	6.939	1.00	8.94	B	O
  ATOM	4146	N	ALA	H	89	21.576	22.237	8.435	1.00	8.77	B	N
  ATOM	4147	CA	ALA	H	89	20.225	21.834	8.022	1.00	8.21	B	C
  ATOM	4148	CB	ALA	H	89	19.811	20.551	8.725	1.00	7.99	B	C
  ATOM	4149	C	ALA	H	89	19.208	22.951	8.293	1.00	7.78	B	C
  ATOM	4150	O	ALA	H	89	18.307	23.249	7.472	1.00	7.88	B	O
  ATOM	4151	N	VAL	H	90	19.383	23.581	9.449	1.00	7.01	B	N
  ATOM	4152	CA	VAL	H	90	18.493	24.639	9.880	1.00	6.26	B	C
  ATOM	4153	CB	VAL	H	90	18.866	25.140	11.289	1.00	5.91	B	C
  ATOM	4154	CG1	VAL	H	90	18.089	26.401	11.626	1.00	5.92	B	C
  ATOM	4155	CG2	VAL	H	90	18.608	24.054	12.318	1.00	5.26	B	C
  ATOM	4156	C	VAL	H	90	18.565	25.785	8.894	1.00	6.25	B	C
  ATOM	4157	O	VAL	H	90	17.547	26.368	8.538	1.00	6.32	B	O
  ATOM	4158	N	THR	H	91	19.771	26.092	8.434	1.00	6.24	B	N
  ATOM	4159	CA	THR	H	91	19.956	27.171	7.478	1.00	6.68	B	C
  ATOM	4160	CB	THR	H	91	21.444	27.375	7.139	1.00	6.62	B	C
  ATOM	4161	OG1	THR	H	91	22.183	27.602	8.345	1.00	7.19	B	O
  ATOM	4162	CG2	THR	H	91	21.619	28.565	6.210	1.00	7.27	B	C
  ATOM	4163	C	THR	H	91	19.203	26.886	6.180	1.00	7.02	B	C
  ATOM	4164	O	THR	H	91	18.505	27.767	5.661	1.00	7.16	B	O
  ATOM	4165	N	GLU	H	92	19.285	25.654	5.679	1.00	7.31	B	N
  ATOM	4166	CA	GLU	H	92	18.529	25.358	4.446	1.00	7.81	B	C
  ATOM	4167	CB	GLU	H	92	18.838	23.939	3.965	1.00	8.23	B	C
  ATOM	4168	CG	GLU	H	92	20.139	23.800	3.192	1.00	10.91	B	C
  ATOM	4169	CD	GLU	H	92	20.104	24.541	1.870	1.00	14.95	B	C
  ATOM	4170	OE1	GLU	H	92	19.434	24.052	0.934	1.00	16.14	B	O
  ATOM	4171	OE2	GLU	H	92	20.751	25.605	1.762	1.00	16.53	B	O
  ATOM	4172	C	GLU	H	92	17.003	25.530	4.644	1.00	7.47	B	C
  ATOM	4173	O	GLU	H	92	16.248	26.099	3.776	1.00	7.32	B	O
  ATOM	4174	N	LEU	H	93	16.541	25.053	5.800	1.00	7.30	B	N
  ATOM	4175	CA	LEU	H	93	15.117	25.171	6.098	1.00	7.47	B	C
  ATOM	4176	CB	LEU	H	93	14.760	24.426	7.385	1.00	7.15	B	C
  ATOM	4177	CG	LEU	H	93	14.797	22.898	7.297	1.00	7.20	B	C
  ATOM	4178	CD1	LEU	H	93	14.346	22.282	8.610	1.00	7.93	B	C
  ATOM	4179	CD2	LEU	H	93	13.941	22.397	6.141	1.00	6.91	B	C
  ATOM	4180	C	LEU	H	93	14.686	26.639	6.179	1.00	7.89	B	C
  ATOM	4181	O	LEU	H	93	13.626	27.012	5.675	1.00	7.94	B	O
  ATOM	4182	N	GLN	H	94	15.527	27.464	6.797	1.00	8.31	B	N
  ATOM	4183	CA	GLN	H	94	15.259	28.893	6.952	1.00	9.05	B	C
  ATOM	4184	CB	GLN	H	94	16.325	29.554	7.831	1.00	9.18	B	C
  ATOM	4185	CG	GLN	H	94	16.331	29.049	9.271	1.00	10.79	B	C
  ATOM	4186	CD	GLN	H	94	17.231	29.868	10.179	1.00	13.82	B	C
  ATOM	4187	OE1	GLN	H	94	17.866	30.828	9.741	1.00	14.98	B	O
  ATOM	4188	NE2	GLN	H	94	17.289	29.493	11.452	1.00	15.25	B	N
  ATOM	4189	C	GLN	H	94	15.190	29.545	5.576	1.00	9.25	B	C
  ATOM	4190	O	GLN	H	94	14.389	30.446	5.329	1.00	9.43	B	O
  ATOM	4191	N	LEU	H	95	16.050	29.058	4.691	1.00	9.55	B	N
  ATOM	4192	CA	LEU	H	95	16.140	29.479	3.294	1.00	10.17	B	C
  ATOM	4193	CB	LEU	H	95	17.327	28.800	2.605	1.00	9.79	B	C
  ATOM	4194	CG	LEU	H	95	18.721	29.321	2.958	1.00	8.86	B	C
  ATOM	4195	CD1	LEU	H	95	19.789	28.548	2.198	1.00	8.31	B	C
  ATOM	4196	CD2	LEU	H	95	18.823	30.809	2.667	1.00	7.62	B	C
  ATOM	4197	C	LEU	H	95	14.865	29.250	2.467	1.00	11.22	B	C
  ATOM	4198	O	LEU	H	95	14.579	30.030	1.560	1.00	11.55	B	O
  ATOM	4199	N	LEU	H	96	14.105	28.190	2.748	1.00	12.40	B	N
  ATOM	4200	CA	LEU	H	96	12.870	27.931	1.929	1.00	13.66	B	C
  ATOM	4201	CB	LEU	H	96	12.338	26.527	2.247	1.00	13.38	B	C
  ATOM	4202	CG	LEU	H	96	13.163	25.359	1.709	1.00	13.32	B	C
  ATOM	4203	CD1	LEU	H	96	12.554	24.028	2.122	1.00	12.84	B	C
  ATOM	4204	CD2	LEU	H	96	13.281	25.453	0.197	1.00	13.38	B	C
  ATOM	4205	C	LEU	H	96	11.631	28.927	1.839	1.00	14.97	B	C
  ATOM	4206	O	LEU	H	96	10.836	28.843	0.903	1.00	15.21	B	O
  ATOM	4207	N	MET	H	97	11.500	29.832	2.808	1.00	16.74	B	N
  ATOM	4208	CA	MET	H	97	10.348	30.575	3.317	1.00	18.96	B	C
  ATOM	4209	CB	MET	H	97	10.619	31.113	4.726	1.00	19.12	B	C
  ATOM	4210	CG	MET	H	97	10.944	30.037	5.758	1.00	21.87	B	C
  ATOM	4211	SD	MET	H	97	9.537	28.994	6.201	1.00	27.46	B	S
  ATOM	4212	CE	MET	H	97	8.667	28.891	4.638	1.00	24.25	B	C
  ATOM	4213	C	MET	H	97	9.912	31.705	2.386	1.00	20.09	B	C
  ATOM	4214	O	MET	H	97	8.725	32.019	2.294	1.00	20.58	B	O
  ATOM	4215	N	GLN	H	98	10.867	32.274	1.658	1.00	21.33	B	N
  ATOM	4216	CA	GLN	H	98	10.593	33.429	0.809	1.00	22.21	B	C
  ATOM	4217	CB	GLN	H	98	11.279	34.679	1.364	1.00	22.53	B	C
  ATOM	4218	CG	GLN	H	98	11.165	34.831	2.872	1.00	23.85	B	C
  ATOM	4219	CD	GLN	H	98	12.329	34.200	3.612	1.00	25.21	B	C
  ATOM	4220	OE1	GLN	H	98	12.539	32.989	3.544	1.00	24.47	B	O
  ATOM	4221	NE2	GLN	H	98	13.058	35.012	4.369	1.00	24.85	B	N
  ATOM	4222	C	GLN	H	98	11.035	33.183	−0.629	1.00	22.15	B	C
  ATOM	4223	O	GLN	H	98	11.448	32.080	−0.982	1.00	21.77	B	O
  ATOM	4224	N	PHE	H	137	5.312	39.031	−3.961	1.00	33.25	B	N
  ATOM	4225	CA	PHE	H	137	5.277	37.601	−4.244	1.00	36.79	B	C
  ATOM	4226	CB	PHE	H	137	3.903	37.193	−4.778	1.00	20.00	B	C
  ATOM	4227	CG	PHE	H	137	2.795	37.350	−3.779	1.00	20.00	B	C
  ATOM	4228	CD1	PHE	H	137	2.542	36.360	−2.843	1.00	20.00	B	C
  ATOM	4229	CE1	PHE	H	137	1.524	36.503	−1.920	1.00	20.00	B	C
  ATOM	4230	CZ	PHE	H	137	0.751	37.645	−1.920	1.00	20.00	B	C
  ATOM	4231	CE2	PHE	H	137	1.003	38.646	−2.836	1.00	20.00	B	C
  ATOM	4232	CD2	PHE	H	137	2.015	38.493	−3.764	1.00	20.00	B	C
  ATOM	4233	C	PHE	H	137	6.359	37.207	−5.241	1.00	48.73	B	C
  ATOM	4234	O	PHE	H	137	6.595	36.022	−5.477	1.00	49.28	B	O
  ATOM	4235	N	LEU	H	138	6.975	38.204	−5.868	1.00	42.04	B	N
  ATOM	4236	CA	LEU	H	138	8.094	37.959	−6.768	1.00	44.26	B	C
  ATOM	4237	CB	LEU	H	138	8.582	39.268	−7.389	1.00	20.00	B	C
  ATOM	4238	CG	LEU	H	138	7.578	40.005	−8.278	1.00	20.00	B	C
  ATOM	4239	CD1	LEU	H	138	8.178	41.296	−8.816	1.00	20.00	B	C
  ATOM	4240	CD2	LEU	H	138	7.101	39.112	−9.411	1.00	20.00	B	C
  ATOM	4241	C	LEU	H	138	9.234	37.274	−6.025	1.00	43.68	B	C
  ATOM	4242	O	LEU	H	138	10.107	36.658	−6.636	1.00	50.27	B	O
  ATOM	4243	N	GLY	H	139	9.188	37.343	−4.698	1.00	38.56	B	N
  ATOM	4244	CA	GLY	H	139	10.191	36.699	−3.860	1.00	47.99	B	C
  ATOM	4245	C	GLY	H	139	10.260	35.202	−4.081	1.00	44.53	B	C
  ATOM	4246	O	GLY	H	139	11.284	34.575	−3.815	1.00	32.21	B	O
  ATOM	4247	N	PHE	H	140	9.173	34.630	−4.590	1.00	46.33	B	N
  ATOM	4248	CA	PHE	H	140	9.070	33.183	−4.735	1.00	42.95	B	C
  ATOM	4249	CB	PHE	H	140	7.618	32.723	−4.576	1.00	20.00	B	C
  ATOM	4250	CG	PHE	H	140	7.058	32.941	−3.201	1.00	20.00	B	C
  ATOM	4251	CD1	PHE	H	140	7.285	32.021	−2.190	1.00	20.00	B	C
  ATOM	4252	CE1	PHE	H	140	6.763	32.217	−0.926	1.00	20.00	B	C
  ATOM	4253	CZ	PHE	H	140	5.992	33.332	−0.664	1.00	20.00	B	C
  ATOM	4254	CE2	PHE	H	140	5.747	34.249	−1.667	1.00	20.00	B	C
  ATOM	4255	CD2	PHE	H	140	6.271	34.047	−2.929	1.00	20.00	B	C
  ATOM	4256	C	PHE	H	140	9.632	32.695	−6.071	1.00	38.13	B	C
  ATOM	4257	O	PHE	H	140	9.693	31.490	−6.322	1.00	57.33	B	O
  ATOM	4258	N	LEU	H	141	10.017	33.631	−6.934	1.00	35.20	B	N
  ATOM	4259	CA	LEU	H	141	10.453	33.294	−8.288	1.00	27.01	B	C
  ATOM	4260	CB	LEU	H	141	11.557	32.235	−8.254	1.00	20.00	B	C
  ATOM	4261	CG	LEU	H	141	12.886	32.672	−7.636	1.00	20.00	B	C
  ATOM	4262	CD1	LEU	H	141	13.836	31.493	−7.513	1.00	20.00	B	C
  ATOM	4263	CD2	LEU	H	141	13.520	33.794	−8.445	1.00	20.00	B	C
  ATOM	4264	C	LEU	H	141	9.287	32.812	−9.144	1.00	35.79	B	C
  ATOM	4265	O	LEU	H	141	8.355	33.567	−9.417	1.00	46.92	B	O
  ATOM	4266	N	LEU	H	142	9.342	31.555	−9.570	1.00	38.67	B	N
  ATOM	4267	CA	LEU	H	142	8.195	30.927	−10.207	1.00	33.84	B	C
  ATOM	4268	CB	LEU	H	142	8.610	30.262	−11.517	1.00	20.00	B	C
  ATOM	4269	CG	LEU	H	142	9.069	31.205	−12.629	1.00	20.00	B	C
  ATOM	4270	CD1	LEU	H	142	9.474	30.415	−13.865	1.00	20.00	B	C
  ATOM	4271	CD2	LEU	H	142	7.974	32.209	−12.964	1.00	20.00	B	C
  ATOM	4272	C	LEU	H	142	7.541	29.910	−9.278	1.00	36.89	B	C
  ATOM	4273	O	LEU	H	142	8.215	29.038	−8.729	1.00	45.42	B	O
  ATOM	4274	N	GLY	H	143	6.268	30.132	−8.975	1.00	26.84	B	N
  ATOM	4275	CA	GLY	H	143	5.577	29.350	−7.958	1.00	27.41	B	C
  ATOM	4276	C	GLY	H	143	4.243	28.849	−8.463	1.00	29.08	B	C
  ATOM	4277	O	GLY	H	143	3.592	29.504	−9.277	1.00	40.24	B	O
  ATOM	4278	N	VAL	H	144	3.848	27.665	−8.010	1.00	30.17	B	N
  ATOM	4279	CA	VAL	H	144	2.550	27.121	−8.373	1.00	34.15	B	C
  ATOM	4280	CB	VAL	H	144	2.497	25.596	−8.195	1.00	20.00	B	C
  ATOM	4281	CG1	VAL	H	144	1.073	25.102	−8.370	1.00	20.00	B	C
  ATOM	4282	CG2	VAL	H	144	3.426	24.913	−9.187	1.00	20.00	B	C
  ATOM	4283	C	VAL	H	144	1.449	27.759	−7.538	1.00	36.67	B	C
  ATOM	4284	O	VAL	H	144	1.723	28.490	−6.587	1.00	42.49	B	O
  ATOM	4285	N	GLY	H	145	0.204	27.526	−7.938	1.00	47.09	B	N
  ATOM	4286	CA	GLY	H	145	−0.946	27.979	−7.166	1.00	44.51	B	C
  ATOM	4287	C	GLY	H	145	−0.857	27.562	−5.712	1.00	44.94	B	C
  ATOM	4288	O	GLY	H	145	−1.097	28.365	−4.810	1.00	40.58	B	O
  ATOM	4289	N	SER	H	146	−0.529	26.297	−5.473	1.00	42.06	B	N
  ATOM	4290	CA	SER	H	146	−0.433	25.788	−4.109	1.00	47.39	B	C
  ATOM	4291	CB	SER	H	146	−0.198	24.275	−4.119	1.00	20.00	B	C
  ATOM	4292	OG	SER	H	146	1.004	23.951	−4.796	1.00	20.00	B	O
  ATOM	4293	C	SER	H	146	0.665	26.482	−3.307	1.00	51.48	B	C
  ATOM	4294	O	SER	H	146	0.481	26.809	−2.131	1.00	47.45	B	O
  ATOM	4295	N	ALA	H	147	1.807	26.710	−3.949	1.00	39.51	B	N
  ATOM	4296	CA	ALA	H	147	2.943	27.334	−3.282	1.00	43.38	B	C
  ATOM	4297	CB	ALA	H	147	4.162	27.326	−4.194	1.00	20.00	B	C
  ATOM	4298	C	ALA	H	147	2.633	28.754	−2.821	1.00	47.39	B	C
  ATOM	4299	O	ALA	H	147	2.997	29.147	−1.713	1.00	50.18	B	O
  ATOM	4300	N	ILE	H	148	1.952	29.520	−3.668	1.00	44.67	B	N
  ATOM	4301	CA	ILE	H	148	1.602	30.892	−3.323	1.00	43.56	B	C
  ATOM	4302	CB	ILE	H	148	0.921	31.615	−4.499	1.00	20.00	B	C
  ATOM	4303	CG1	ILE	H	148	1.854	31.657	−5.711	1.00	20.00	B	C
  ATOM	4304	CD1	ILE	H	148	1.259	32.353	−6.916	1.00	20.00	B	C
  ATOM	4305	CG2	ILE	H	148	0.504	33.020	−4.092	1.00	20.00	B	C
  ATOM	4306	C	ILE	H	148	0.672	30.913	−2.117	1.00	51.18	B	C
  ATOM	4307	O	ILE	H	148	0.830	31.730	−1.208	1.00	39.17	B	O
  ATOM	4308	N	ALA	H	149	−0.289	29.995	−2.109	1.00	42.17	B	N
  ATOM	4309	CA	ALA	H	149	−1.233	29.895	−1.007	1.00	36.76	B	C
  ATOM	4310	CB	ALA	H	149	−2.297	28.854	−1.312	1.00	20.00	B	C
  ATOM	4311	C	ALA	H	149	−0.490	29.541	0.272	1.00	45.19	B	C
  ATOM	4312	O	ALA	H	149	−0.771	30.090	1.340	1.00	47.83	B	O
  ATOM	4313	N	SER	H	150	0.471	28.630	0.157	1.00	43.64	B	N
  ATOM	4314	CA	SER	H	150	1.250	28.218	1.315	1.00	43.46	B	C
  ATOM	4315	CB	SER	H	150	2.211	27.088	0.943	1.00	20.00	B	C
  ATOM	4316	OG	SER	H	150	3.113	27.499	−0.069	1.00	20.00	B	O
  ATOM	4317	C	SER	H	150	2.024	29.408	1.865	1.00	44.80	B	C
  ATOM	4318	O	SER	H	150	2.095	29.610	3.077	1.00	41.55	B	O
  ATOM	4319	N	GLY	H	151	2.590	30.205	0.964	1.00	27.01	B	N
  ATOM	4320	CA	GLY	H	151	3.342	31.379	1.362	1.00	35.21	B	C
  ATOM	4321	C	GLY	H	151	2.454	32.375	2.078	1.00	42.40	B	C
  ATOM	4322	O	GLY	H	151	2.849	32.969	3.083	1.00	45.11	B	O
  ATOM	4323	N	VAL	H	152	1.241	32.551	1.563	1.00	40.20	B	N
  ATOM	4324	CA	VAL	H	152	0.293	33.471	2.174	1.00	46.73	B	C
  ATOM	4325	CB	VAL	H	152	−1.000	33.585	1.346	1.00	20.00	B	C
  ATOM	4326	CG1	VAL	H	152	−1.970	34.551	2.009	1.00	20.00	B	C
  ATOM	4327	CG2	VAL	H	152	−0.682	34.029	−0.073	1.00	20.00	B	C
  ATOM	4328	C	VAL	H	152	−0.052	32.995	3.579	1.00	48.62	B	C
  ATOM	4329	O	VAL	H	152	−0.133	33.792	4.517	1.00	49.32	B	O
  ATOM	4330	N	ALA	H	153	−0.239	31.686	3.722	1.00	35.09	B	N
  ATOM	4331	CA	ALA	H	153	−0.567	31.112	5.018	1.00	42.37	B	C
  ATOM	4332	CB	ALA	H	153	−0.849	29.625	4.885	1.00	20.00	B	C
  ATOM	4333	C	ALA	H	153	0.578	31.353	5.992	1.00	37.79	B	C
  ATOM	4334	O	ALA	H	153	0.359	31.696	7.154	1.00	39.25	B	O
  ATOM	4335	N	VAL	H	154	1.802	31.189	5.502	1.00	38.88	B	N
  ATOM	4336	CA	VAL	H	154	2.982	31.394	6.328	1.00	35.53	B	C
  ATOM	4337	CB	VAL	H	154	4.274	31.042	5.568	1.00	20.00	B	C
  ATOM	4338	CG1	VAL	H	154	5.489	31.267	6.454	1.00	20.00	B	C
  ATOM	4339	CG2	VAL	H	154	4.223	29.605	5.074	1.00	20.00	B	C
  ATOM	4340	C	VAL	H	154	3.053	32.842	6.791	1.00	41.00	B	C
  ATOM	4341	O	VAL	H	154	3.380	33.118	7.945	1.00	50.08	B	O
  ATOM	4342	N	SER	H	155	2.742	33.766	5.888	1.00	37.82	B	N
  ATOM	4343	CA	SER	H	155	2.753	35.181	6.232	1.00	44.68	B	C
  ATOM	4344	CB	SER	H	155	2.496	36.038	4.991	1.00	20.00	B	C
  ATOM	4345	OG	SER	H	155	1.238	35.736	4.414	1.00	20.00	B	O
  ATOM	4346	C	SER	H	155	1.706	35.477	7.300	1.00	41.82	B	C
  ATOM	4347	O	SER	H	155	1.960	36.224	8.245	1.00	49.37	B	O
  ATOM	4348	N	LYS	H	156	0.528	34.880	7.144	1.00	36.99	B	N
  ATOM	4349	CA	LYS	H	156	−0.559	35.059	8.102	1.00	35.11	B	C
  ATOM	4350	CB	LYS	H	156	−1.843	34.411	7.579	1.00	20.00	B	C
  ATOM	4351	CG	LYS	H	156	−2.334	34.983	6.259	1.00	20.00	B	C
  ATOM	4352	CD	LYS	H	156	−3.611	34.297	5.801	1.00	20.00	B	C
  ATOM	4353	CE	LYS	H	156	−4.102	34.869	4.481	1.00	20.00	B	C
  ATOM	4354	NZ	LYS	H	156	−5.353	34.206	4.020	1.00	20.00	B	N
  ATOM	4355	C	LYS	H	156	−0.210	34.493	9.476	1.00	35.98	B	C
  ATOM	4356	O	LYS	H	156	−0.535	35.081	10.507	1.00	42.31	B	O
  ATOM	4357	N	VAL	H	157	0.448	33.339	9.470	1.00	37.88	B	N
  ATOM	4358	CA	VAL	H	157	0.794	32.617	10.689	1.00	50.94	B	C
  ATOM	4359	CB	VAL	H	157	1.143	31.145	10.396	1.00	20.00	B	C
  ATOM	4360	CG1	VAL	H	157	1.572	30.439	11.672	1.00	20.00	B	C
  ATOM	4361	CG2	VAL	H	157	−0.043	30.435	9.762	1.00	20.00	B	C
  ATOM	4362	C	VAL	H	157	1.962	33.277	11.415	1.00	47.82	B	C
  ATOM	4363	O	VAL	H	157	2.296	32.905	12.541	1.00	56.87	B	O
  ATOM	4364	N	LEU	H	158	2.533	34.304	10.794	1.00	39.52	B	N
  ATOM	4365	CA	LEU	H	158	3.727	34.956	11.320	1.00	50.27	B	C
  ATOM	4366	CB	LEU	H	158	4.080	36.188	10.484	1.00	20.00	B	C
  ATOM	4367	CG	LEU	H	158	4.493	35.927	9.034	1.00	20.00	B	C
  ATOM	4368	CD1	LEU	H	158	4.688	37.237	8.287	1.00	20.00	B	C
  ATOM	4369	CD2	LEU	H	158	5.754	35.079	8.976	1.00	20.00	B	C
  ATOM	4370	C	LEU	H	158	3.589	35.334	12.794	1.00	54.47	B	C
  ATOM	4371	O	LEU	H	158	4.512	35.127	13.582	1.00	49.26	B	O
  ATOM	4372	N	HIS	H	159	2.448	35.754	13.309	1.00	59.45	B	N
  ATOM	4373	CA	HIS	H	159	2.473	36.028	14.762	1.00	49.11	B	C
  ATOM	4374	CB	HIS	H	159	1.136	36.614	15.221	1.00	20.00	B	C
  ATOM	4375	CG	HIS	H	159	0.780	37.903	14.548	1.00	20.00	B	C
  ATOM	4376	ND1	HIS	H	159	1.149	39.132	15.051	1.00	20.00	B	N
  ATOM	4377	CE1	HIS	H	159	0.699	40.085	14.254	1.00	20.00	B	C
  ATOM	4378	NE2	HIS	H	159	0.052	39.519	13.252	1.00	20.00	B	N
  ATOM	4379	CD2	HIS	H	159	0.087	38.155	13.412	1.00	20.00	B	C
  ATOM	4380	C	HIS	H	159	2.830	34.775	15.616	1.00	44.09	B	C
  ATOM	4381	O	HIS	H	159	3.627	34.822	16.600	1.00	42.13	B	O
  ATOM	4382	N	LEU	H		160	2.261	33.646	15.207	1.00	37.55	B	N
  ATOM	4383	CA	LEU	H	160	2.402	32.391	15.934	1.00	43.52	B	C
  ATOM	4384	CB	LEU	H	160	1.521	31.310	15.302	1.00	20.00	B	C
  ATOM	4385	CG	LEU	H		160	0.018	31.596	15.268	1.00	20.00	B	C
  ATOM	4386	CD1	LEU	H		160	−0.734	30.443	14.620	1.00	20.00	B	C
  ATOM	4387	CD2	LEU	H		160	−0.509	31.865	16.668	1.00	20.00	B	C
  ATOM	4388	C	LEU	H		160	3.839	31.887	16.044	1.00	47.22	B	C
  ATOM	4389	O	LEU	H		160	4.233	31.383	17.091	1.00	43.25	B	O
  ATOM	4390	N	GLU	H	161	4.620	32.011	14.976	1.00	40.88	B	N
  ATOM	4391	CA	GLU	H	161	5.996	31.524	15.008	1.00	40.61	B	C
  ATOM	4392	CB	GLU	H	161	6.644	31.658	13.628	1.00	20.00	B	C
  ATOM	4393	CG	GLU	H	161	5.936	30.878	12.532	1.00	20.00	B	C
  ATOM	4394	CD	GLU	H	161	6.606	31.031	11.181	1.00	20.00	B	C
  ATOM	4395	OE1	GLU	H	161	6.113	30.437	10.200	1.00	20.00	B	O
  ATOM	4396	OE2	GLU	H	161	7.628	31.745	11.101	1.00	20.00	B	O
  ATOM	4397	C	GLU	H	161	6.833	32.259	16.054	1.00	39.76	B	C
  ATOM	4398	O	GLU	H	161	7.606	31.642	16.795	1.00	44.02	B	O
  ATOM	4399	N	GLY	H	162	6.679	33.566	16.211	1.00	34.18	B	N
  ATOM	4400	CA	GLY	H	162	7.497	34.204	17.230	1.00	35.01	B	C
  ATOM	4401	C	GLY	H	162	7.170	33.593	18.586	1.00	34.86	B	C
  ATOM	4402	O	GLY	H	162	8.065	33.226	19.372	1.00	47.81	B	O
  ATOM	4403	N	GLU	H	163	5.875	33.431	18.838	1.00	40.78	B	N
  ATOM	4404	CA	GLU	H	163	5.403	32.797	20.058	1.00	37.20	B	C
  ATOM	4405	CB	GLU	H	163	3.877	32.847	20.137	1.00	20.00	B	C
  ATOM	4406	CG	GLU	H	163	3.301	34.254	20.134	1.00	20.00	B	C
  ATOM	4407	CD	GLU	H	163	1.788	34.264	20.214	1.00	20.00	B	C
  ATOM	4408	OE1	GLU	H	163	1.199	35.365	20.219	1.00	20.00	B	O
  ATOM	4409	OE2	GLU	H	163	1.186	33.171	20.273	1.00	20.00	B	O
  ATOM	4410	C	GLU	H	163	5.884	31.355	20.065	1.00	46.12	B	C
  ATOM	4411	O	GLU	H	163	6.295	30.824	21.098	1.00	58.66	B	O
  ATOM	4412	N	VAL	H	164	5.832	30.731	18.893	1.00	42.23	B	N
  ATOM	4413	CA	VAL	H	164	6.270	29.353	18.740	1.00	35.45	B	C
  ATOM	4414	CB	VAL	H	164	6.021	28.836	17.311	1.00	20.00	B	C
  ATOM	4415	CG1	VAL	H	164	6.488	27.394	17.181	1.00	20.00	B	C
  ATOM	4416	CG2	VAL	H	164	4.549	28.962	16.951	1.00	20.00	B	C
  ATOM	4417	C	VAL	H	164	7.753	29.241	19.061	1.00	46.32	B	C
  ATOM	4418	O	VAL	H	164	8.180	28.290	19.709	1.00	45.08	B	O
  ATOM	4419	N	ASN	H	165	8.536	30.217	18.611	1.00	40.82	B	N
  ATOM	4420	CA	ASN	H	165	9.966	30.227	18.891	1.00	46.48	B	C
  ATOM	4421	CB	ASN	H	165	10.653	31.372	18.145	1.00	20.00	B	C
  ATOM	4422	CG	ASN	H	165	10.488	31.270	16.642	1.00	20.00	B	C
  ATOM	4423	OD1	ASN	H	165	10.982	32.113	15.893	1.00	20.00	B	O
  ATOM	4424	ND2	ASN	H	165	9.792	30.232	16.192	1.00	20.00	B	N
  ATOM	4425	C	ASN	H	165	10.227	30.342	20.389	1.00	50.90	B	C
  ATOM	4426	O	ASN	H	165	11.099	29.655	20.941	1.00	47.11	B	O
  ATOM	4427	N	LYS	H	166	9.453	31.198	21.052	1.00	48.36	B	N
  ATOM	4428	CA	LYS	H	166	9.605	31.351	22.495	1.00	38.71	B	C
  ATOM	4429	CB	LYS	H	166	8.692	32.461	23.019	1.00	20.00	B	C
  ATOM	4430	CG	LYS	H	166	8.968	33.828	22.414	1.00	20.00	B	C
  ATOM	4431	CD	LYS	H	166	8.030	34.881	22.980	1.00	20.00	B	C
  ATOM	4432	CE	LYS	H	166	8.306	36.249	22.376	1.00	20.00	B	C
  ATOM	4433	NZ	LYS	H	166	7.396	37.292	22.923	1.00	20.00	B	N
  ATOM	4434	C	LYS	H	166	9.284	30.029	23.192	1.00	45.07	B	C
  ATOM	4435	O	LYS	H	166	9.977	29.609	24.131	1.00	56.09	B	O
  ATOM	4436	N	ILE	H	167	8.238	29.366	22.709	1.00	42.02	B	N
  ATOM	4437	CA	ILE	H	167	7.817	28.091	23.272	1.00	43.86	B	C
  ATOM	4438	CB	ILE	H	167	6.527	27.577	22.607	1.00	20.00	B	C
  ATOM	4439	CG1	ILE	H	167	5.388	28.580	22.807	1.00	20.00	B	C
  ATOM	4440	CD1	ILE	H	167	4.079	28.150	22.181	1.00	20.00	B	C
  ATOM	4441	CG2	ILE	H	167	6.147	26.214	23.164	1.00	20.00	B	C
  ATOM	4442	C	ILE	H	167	8.916	27.053	23.099	1.00	49.02	B	C
  ATOM	4443	O	ILE	H	167	9.178	26.260	23.998	1.00	37.71	B	O
  ATOM	4444	N	LYS	H	168	9.557	27.068	21.935	1.00	33.87	B	N
  ATOM	4445	CA	LYS	H	168	10.644	26.146	21.640	1.00	35.11	B	C
  ATOM	4446	CB	LYS	H	168	11.103	26.304	20.189	1.00	20.00	B	C
  ATOM	4447	CG	LYS	H	168	10.014	26.040	19.162	1.00	20.00	B	C
  ATOM	4448	CD	LYS	H	168	10.535	26.220	17.746	1.00	20.00	B	C
  ATOM	4449	CE	LYS	H	168	9.445	25.959	16.719	1.00	20.00	B	C
  ATOM	4450	NZ	LYS	H	168	9.941	26.134	15.326	1.00	20.00	B	N
  ATOM	4451	C	LYS	H	168	11.813	26.380	22.588	1.00	39.27	B	C
  ATOM	4452	O	LYS	H	168	12.422	25.429	23.078	1.00	32.39	B	O
  ATOM	4453	N	SER	H	169	12.121	27.647	22.854	1.00	41.30	B	N
  ATOM	4454	CA	SER	H	169	13.203	27.963	23.783	1.00	43.23	B	C
  ATOM	4455	CB	SER	H	169	13.446	29.472	23.832	1.00	20.00	B	C
  ATOM	4456	OG	SER	H	169	12.284	30.162	24.259	1.00	20.00	B	O
  ATOM	4457	C	SER	H	169	12.865	27.436	25.178	1.00	41.44	B	C
  ATOM	4458	O	SER	H	169	13.723	26.871	25.883	1.00	44.82	B	O
  ATOM	4459	N	ALA	H	170	11.604	27.605	25.566	1.00	39.78	B	N
  ATOM	4460	CA	ALA	H	170	11.161	27.131	26.870	1.00	41.01	B	C
  ATOM	4461	CB	ALA	H	170	9.720	27.541	27.124	1.00	20.00	B	C
  ATOM	4462	C	ALA	H	170	11.308	25.615	26.948	1.00	46.04	B	C
  ATOM	4463	O	ALA	H	170	11.743	25.072	27.964	1.00	46.67	B	O
  ATOM	4464	N	LEU	H	171	10.955	24.940	25.859	1.00	34.26	B	N
  ATOM	4465	CA	LEU	H	171	11.050	23.489	25.782	1.00	37.69	B	C
  ATOM	4466	CB	LEU	H	171	10.458	22.982	24.466	1.00	20.00	B	C
  ATOM	4467	CG	LEU	H	171	8.984	23.305	24.216	1.00	20.00	B	C
  ATOM	4468	CD1	LEU	H	171	8.529	22.743	22.878	1.00	20.00	B	C
  ATOM	4469	CD2	LEU	H	171	8.118	22.773	25.348	1.00	20.00	B	C
  ATOM	4470	C	LEU	H	171	12.499	23.044	25.912	1.00	44.67	B	C
  ATOM	4471	O	LEU	H	171	12.797	22.054	26.579	1.00	34.27	B	O
  ATOM	4472	N	LEU	H	172	13.400	23.783	25.272	1.00	34.80	B	N
  ATOM	4473	CA	LEU	H	172	14.817	23.464	25.344	1.00	28.87	B	C
  ATOM	4474	CB	LEU	H	172	15.626	24.402	24.447	1.00	20.00	B	C
  ATOM	4475	CG	LEU	H	172	15.281	24.379	22.956	1.00	20.00	B	C
  ATOM	4476	CD1	LEU	H	172	16.158	25.355	22.186	1.00	20.00	B	C
  ATOM	4477	CD2	LEU	H	172	15.416	22.972	22.395	1.00	20.00	B	C
  ATOM	4478	C	LEU	H	172	15.291	23.577	26.786	1.00	29.90	B	C
  ATOM	4479	O	LEU	H	172	16.022	22.714	27.272	1.00	41.09	B	O
  ATOM	4480	N	SER	H	173	14.862	24.629	27.480	1.00	35.08	B	N
  ATOM	4481	CA	SER	H	173	15.184	24.754	28.902	1.00	35.53	B	C
  ATOM	4482	CB	SER	H	173	14.727	26.109	29.442	1.00	20.00	B	C
  ATOM	4483	OG	SER	H	173	13.328	26.272	29.294	1.00	20.00	B	O
  ATOM	4484	C	SER	H	173	14.506	23.618	29.673	1.00	35.07	B	C
  ATOM	4485	O	SER	H	173	15.056	23.037	30.609	1.00	51.28	B	O
  ATOM	4486	N	THR	H	174	13.286	23.341	29.234	1.00	46.35	B	N
  ATOM	4487	CA	THR	H	174	12.335	22.383	29.786	1.00	43.83	B	C
  ATOM	4488	CB	THR	H	174	10.885	22.764	29.429	1.00	20.00	B	C
  ATOM	4489	OG1	THR	H	174	10.725	22.762	28.004	1.00	20.00	B	O
  ATOM	4490	CG2	THR	H	174	10.547	24.144	29.971	1.00	20.00	B	C
  ATOM	4491	C	THR	H	174	12.616	20.979	29.263	1.00	52.54	B	C
  ATOM	4492	O	THR	H	174	12.523	20.726	28.063	1.00	64.10	B	O
  ATOM	4493	N	ASN	H	175	12.974	20.071	30.165	1.00	55.57	B	N
  ATOM	4494	CA	ASN	H	175	13.072	18.660	29.817	1.00	40.58	B	C
  ATOM	4495	CB	ASN	H	175	13.942	17.915	30.831	1.00	20.00	B	C
  ATOM	4496	CG	ASN	H	175	15.405	18.303	30.740	1.00	20.00	B	C
  ATOM	4497	OD1	ASN	H	175	15.868	18.788	29.708	1.00	20.00	B	O
  ATOM	4498	ND2	ASN	H	175	16.139	18.099	31.827	1.00	20.00	B	N
  ATOM	4499	C	ASN	H	175	11.695	18.009	29.714	1.00	43.65	B	C
  ATOM	4500	O	ASN	H	175	10.972	17.912	30.705	1.00	53.11	B	O
  ATOM	4501	N	LYS	H	176	11.296	17.666	28.491	1.00	44.89	B	N
  ATOM	4502	CA	LYS	H	176	9.986	17.068	28.250	1.00	46.42	B	C
  ATOM	4503	CB	LYS	H	176	8.873	18.052	28.618	1.00	20.00	B	C
  ATOM	4504	CG	LYS	H	176	8.873	18.468	30.088	1.00	20.00	B	C
  ATOM	4505	CD	LYS	H	176	7.844	19.557	30.362	1.00	20.00	B	C
  ATOM	4506	CE	LYS	H	176	7.773	19.904	31.841	1.00	20.00	B	C
  ATOM	4507	NZ	LYS	H	176	6.701	20.899	32.121	1.00	20.00	B	N
  ATOM	4508	C	LYS	H	176	9.829	16.596	26.806	1.00	45.00	B	C
  ATOM	4509	O	LYS	H	176	10.272	17.264	25.871	1.00	60.64	B	O
  ATOM	4510	N	ALA	H	177	9.245	15.415	26.634	1.00	46.01	B	N
  ATOM	4511	CA	ALA	H	177	8.914	14.913	25.306	1.00	43.65	B	C
  ATOM	4512	CB	ALA	H	177	8.530	13.442	25.374	1.00	20.00	B	C
  ATOM	4513	C	ALA	H	177	7.789	15.731	24.686	1.00	41.42	B	C
  ATOM	4514	O	ALA	H	177	7.894	16.184	23.547	1.00	45.37	B	O
  ATOM	4515	N	VAL	H	178	6.736	15.960	25.463	1.00	35.70	B	N
  ATOM	4516	CA	VAL	H	178	5.642	16.820	25.037	1.00	43.93	B	C
  ATOM	4517	CB	VAL	H	178	4.383	15.999	24.710	1.00	20.00	B	C
  ATOM	4518	CG1	VAL	H	178	3.229	16.919	24.341	1.00	20.00	B	C
  ATOM	4519	CG2	VAL	H	178	4.672	15.014	23.585	1.00	20.00	B	C
  ATOM	4520	C	VAL	H	178	5.313	17.836	26.124	1.00	34.16	B	C
  ATOM	4521	O	VAL	H	178	5.395	17.527	27.311	1.00	44.45	B	O
  ATOM	4522	N	VAL	H	179	5.028	19.069	25.717	1.00	44.87	B	N
  ATOM	4523	CA	VAL	H	179	4.818	20.155	26.667	1.00	38.47	B	C
  ATOM	4524	CB	VAL	H	179	6.150	20.766	27.131	1.00	20.00	B	C
  ATOM	4525	CG1	VAL	H	179	5.908	21.808	28.221	1.00	20.00	B	C
  ATOM	4526	CG2	VAL	H	179	7.097	19.678	27.609	1.00	20.00	B	C
  ATOM	4527	C	VAL	H	179	3.967	21.265	26.070	1.00	44.79	B	C
  ATOM	4528	O	VAL	H	179	4.226	21.727	24.959	1.00	51.88	B	O
  ATOM	4529	N	SER	H	180	3.025	21.765	26.862	1.00	45.23	B	N
  ATOM	4530	CA	SER	H	180	2.226	22.915	26.463	1.00	48.99	B	C
  ATOM	4531	CB	SER	H	180	0.976	23.033	27.340	1.00	20.00	B	C
  ATOM	4532	OG	SER	H	180	1.321	23.322	28.683	1.00	20.00	B	O
  ATOM	4533	C	SER	H	180	3.047	24.198	26.532	1.00	48.15	B	C
  ATOM	4534	O	SER	H	180	3.568	24.553	27.589	1.00	60.42	B	O
  ATOM	4535	N	LEU	H	181	3.261	24.821	25.378	1.00	42.42	B	N
  ATOM	4536	CA	LEU	H	181	3.872	26.143	25.325	1.00	43.22	B	C
  ATOM	4537	CB	LEU	H	181	4.252	26.498	23.888	1.00	20.00	B	C
  ATOM	4538	CG	LEU	H	181	5.279	25.577	23.233	1.00	20.00	B	C
  ATOM	4539	CD1	LEU	H	181	5.583	26.043	21.818	1.00	20.00	B	C
  ATOM	4540	CD2	LEU	H	181	6.541	25.519	24.073	1.00	20.00	B	C
  ATOM	4541	C	LEU	H	181	2.929	27.199	25.884	1.00	29.14	B	C
  ATOM	4542	O	LEU	H	181	1.891	27.494	25.291	1.00	43.42	B	O
  ATOM	4543	N	SER	H	182	3.271	27.735	27.051	1.00	41.83	B	N
  ATOM	4544	CA	SER	H	182	2.365	28.619	27.770	1.00	53.52	B	C
  ATOM	4545	CB	SER	H	182	2.034	28.053	29.152	1.00	20.00	B	C
  ATOM	4546	OG	SER	H	182	3.184	28.019	29.978	1.00	20.00	B	O
  ATOM	4547	C	SER	H	182	2.914	30.036	27.891	1.00	44.76	B	C
  ATOM	4548	O	SER	H	182	4.095	30.236	28.178	1.00	37.73	B	O
  ATOM	4549	N	ASN	H	183	2.072	31.008	27.556	1.00	47.84	B	N
  ATOM	4550	CA	ASN	H	183	2.258	32.384	27.996	1.00	59.45	B	C
  ATOM	4551	CB	ASN	H	183	2.304	33.316	26.782	1.00	20.00	B	C
  ATOM	4552	CG	ASN	H	183	3.512	33.066	25.897	1.00	20.00	B	C
  ATOM	4553	OD1	ASN	H	183	4.574	32.671	26.379	1.00	20.00	B	O
  ATOM	4554	ND2	ASN	H	183	3.384	33.386	24.615	1.00	20.00	B	N
  ATOM	4555	C	ASN	H	183	1.117	32.791	28.924	1.00	75.41	B	C
  ATOM	4556	O	ASN	H	183	−0.008	32.318	28.769	1.00	102.31	B	O
  ATOM	4557	N	GLY	H	184	1.432	33.563	29.959	1.00	79.30	B	N
  ATOM	4558	CA	GLY	H	184	0.435	33.947	30.957	1.00	88.92	B	C
  ATOM	4559	C	GLY	H	184	−0.954	33.397	30.674	1.00	101.85	B	C
  ATOM	4560	O	GLY	H	184	−1.760	34.037	29.999	1.00	113.48	B	O
  ATOM	4561	N	VAL	H	185	−1.218	32.190	31.167	1.00	86.84	B	N
  ATOM	4562	CA	VAL	H	185	−2.573	31.636	31.236	1.00	81.80	B	C
  ATOM	4563	CB	VAL	H	185	−3.558	32.579	31.958	1.00	20.00	B	C
  ATOM	4564	CG1	VAL	H	185	−4.974	32.022	31.887	1.00	20.00	B	C
  ATOM	4565	CG2	VAL	H	185	−3.135	32.783	33.405	1.00	20.00	B	C
  ATOM	4566	C	VAL	H	185	−3.164	31.228	29.887	1.00	81.69	B	C
  ATOM	4567	O	VAL	H	185	−4.347	30.900	29.801	1.00	99.84	B	O
  ATOM	4568	N	SER	H	186	−2.336	31.193	28.848	1.00	70.63	B	N
  ATOM	4569	CA	SER	H	186	−2.819	30.830	27.519	1.00	72.29	B	C
  ATOM	4570	CB	SER	H	186	−3.084	32.081	26.679	1.00	20.00	B	C
  ATOM	4571	OG	SER	H	186	−1.884	32.787	26.420	1.00	20.00	B	O
  ATOM	4572	C	SER	H	186	−1.865	29.891	26.789	1.00	62.99	B	C
  ATOM	4573	O	SER	H	186	−0.655	30.115	26.765	1.00	58.35	B	O
  ATOM	4574	N	VAL	H	187	−2.422	28.851	26.177	1.00	66.49	B	N
  ATOM	4575	CA	VAL	H	187	−1.627	27.877	25.438	1.00	57.36	B	C
  ATOM	4576	CB	VAL	H	187	−2.284	26.484	25.457	1.00	20.00	B	C
  ATOM	4577	CG1	VAL	H	187	−1.504	25.516	24.583	1.00	20.00	B	C
  ATOM	4578	CG2	VAL	H	187	−2.383	25.963	26.883	1.00	20.00	B	C
  ATOM	4579	C	VAL	H	187	−1.432	28.317	23.991	1.00	53.67	B	C
  ATOM	4580	O	VAL	H	187	−2.401	28.531	23.262	1.00	50.10	B	O
  ATOM	4581	N	LEU	H	188	−0.176	28.476	23.588	1.00	43.20	B	N
  ATOM	4582	CA	LEU	H	188	0.143	28.854	22.217	1.00	41.76	B	C
  ATOM	4583	CB	LEU	H	188	1.487	29.581	22.160	1.00	20.00	B	C
  ATOM	4584	CG	LEU	H	188	1.549	30.938	22.862	1.00	20.00	B	C
  ATOM	4585	CD1	LEU	H	188	2.957	31.507	22.799	1.00	20.00	B	C
  ATOM	4586	CD2	LEU	H	188	0.548	31.907	22.250	1.00	20.00	B	C
  ATOM	4587	C	LEU	H	188	0.166	27.634	21.304	1.00	44.75	B	C
  ATOM	4588	O	LEU	H	188	−0.074	27.743	20.102	1.00	45.28	B	O
  ATOM	4589	N	THR	H	189	0.390	26.466	21.897	1.00	39.28	B	N
  ATOM	4590	CA	THR	H	189	0.552	25.235	21.133	1.00	36.51	B	C
  ATOM	4591	CB	THR	H	189	1.229	25.498	19.774	1.00	20.00	B	C
  ATOM	4592	OG1	THR	H	189	2.554	26.001	19.986	1.00	20.00	B	O
  ATOM	4593	CG2	THR	H	189	0.430	26.512	18.968	1.00	20.00	B	C
  ATOM	4594	C	THR	H	189	1.362	24.208	21.926	1.00	45.83	B	C
  ATOM	4595	O	THR	H	189	1.419	24.267	23.154	1.00	42.57	B	O
  ATOM	4596	N	SER	H	190	1.947	23.241	21.226	1.00	40.44	B	N
  ATOM	4597	CA	SER	H	190	2.691	22.171	21.881	1.00	41.82	B	C
  ATOM	4598	CB	SER	H	190	2.022	20.815	21.632	1.00	20.00	B	C
  ATOM	4599	OG	SER	H	190	2.225	20.376	20.300	1.00	20.00	B	O
  ATOM	4600	C	SER	H	190	4.152	22.141	21.437	1.00	33.81	B	C
  ATOM	4601	O	SER	H	190	4.473	22.505	20.306	1.00	49.61	B	O
  ATOM	4602	N	LYS	H	191	5.040	21.855	22.385	1.00	37.37	B	N
  ATOM	4603	CA	LYS	H	191	6.463	21.711	22.098	1.00	41.23	B	C
  ATOM	4604	CB	LYS	H	191	7.285	22.617	23.021	1.00	20.00	B	C
  ATOM	4605	CG	LYS	H	191	7.104	24.102	22.750	1.00	20.00	B	C
  ATOM	4606	CD	LYS	H	191	7.981	24.949	23.658	1.00	20.00	B	C
  ATOM	4607	CE	LYS	H	191	7.790	26.435	23.369	1.00	20.00	B	C
  ATOM	4608	NZ	LYS	H	191	8.364	27.306	24.434	1.00	20.00	B	N
  ATOM	4609	C	LYS	H	191	6.906	20.260	22.268	1.00	35.03	B	C
  ATOM	4610	O	LYS	H	191	6.828	19.710	23.365	1.00	40.06	B	O
  ATOM	4611	N	VAL	H	192	7.443	19.670	21.205	1.00	33.70	B	N
  ATOM	4612	CA	VAL	H	192	7.787	18.250	21.221	1.00	27.61	B	C
  ATOM	4613	CB	VAL	H	192	6.974	17.456	20.182	1.00	20.00	B	C
  ATOM	4614	CG1	VAL	H	192	7.313	15.975	20.263	1.00	20.00	B	C
  ATOM	4615	CG2	VAL	H	192	5.487	17.679	20.391	1.00	20.00	B	C
  ATOM	4616	C	VAL	H	192	9.277	18.011	20.985	1.00	31.74	B	C
  ATOM	4617	O	VAL	H	192	9.931	18.771	20.272	1.00	25.58	B	O
  ATOM	4618	N	LEU	H	193	9.792	16.921	21.550	1.00	28.88	B	N
  ATOM	4619	CA	LEU	H	193	11.190	16.530	21.360	1.00	34.36	B	C
  ATOM	4620	CB	LEU	H	193	12.061	17.069	22.505	1.00	20.00	B	C
  ATOM	4621	CG	LEU	H	193	12.332	18.577	22.614	1.00	20.00	B	C
  ATOM	4622	CD1	LEU	H	193	12.987	18.914	23.949	1.00	20.00	B	C
  ATOM	4623	CD2	LEU	H	193	13.194	19.076	21.459	1.00	20.00	B	C
  ATOM	4624	C	LEU	H	193	11.335	15.008	21.281	1.00	33.03	B	C
  ATOM	4625	O	LEU	H	193	11.373	14.331	22.310	1.00	44.93	B	O
  ATOM	4626	N	ASP	H	194	11.579	14.498	20.077	1.00	35.09	B	N
  ATOM	4627	CA	ASP	H	194	11.209	13.127	19.730	1.00	41.39	B	C
  ATOM	4628	CB	ASP	H	194	11.269	12.925	18.214	1.00	20.00	B	C
  ATOM	4629	CG	ASP	H	194	10.132	13.626	17.485	1.00	20.00	B	C
  ATOM	4630	OD1	ASP	H	194	9.081	13.873	18.115	1.00	20.00	B	O
  ATOM	4631	OD2	ASP	H	194	10.305	13.969	16.296	1.00	20.00	B	O
  ATOM	4632	C	ASP	H	194	12.091	12.100	20.433	1.00	38.04	B	C
  ATOM	4633	O	ASP	H	194	11.796	10.904	20.429	1.00	48.03	B	O
  ATOM	4634	N	LEU	H	195	13.174	12.576	21.039	1.00	43.64	B	N
  ATOM	4635	CA	LEU	H	195	14.206	11.690	21.555	1.00	35.97	B	C
  ATOM	4636	CB	LEU	H	195	15.532	11.935	20.832	1.00	20.00	B	C
  ATOM	4637	CG	LEU	H	195	15.563	11.586	19.340	1.00	20.00	B	C
  ATOM	4638	CD1	LEU	H	195	16.947	11.852	18.750	1.00	20.00	B	C
  ATOM	4639	CD2	LEU	H	195	15.118	10.144	19.081	1.00	20.00	B	C
  ATOM	4640	C	LEU	H	195	14.386	11.839	23.063	1.00	43.63	B	C
  ATOM	4641	O	LEU	H	195	15.068	11.036	23.699	1.00	34.71	B	O
  ATOM	4642	N	ASN	H	196	13.689	12.808	23.645	1.00	44.30	B	N
  ATOM	4643	CA	ASN	H	196	13.886	13.151	25.047	1.00	42.38	B	C
  ATOM	4644	CB	ASN	H	196	12.955	14.290	25.454	1.00	20.00	B	C
  ATOM	4645	CG	ASN	H	196	13.376	15.618	24.868	1.00	20.00	B	C
  ATOM	4646	OD1	ASN	H	196	14.538	15.815	24.513	1.00	20.00	B	O
  ATOM	4647	ND2	ASN	H	196	12.439	16.555	24.800	1.00	20.00	B	N
  ATOM	4648	C	ASN	H	196	13.721	11.972	26.000	1.00	43.66	B	C
  ATOM	4649	O	ASN	H	196	14.499	11.814	26.940	1.00	33.62	B	O
  ATOM	4650	N	ASN	H	197	12.649	11.208	25.817	1.00	34.31	B	N
  ATOM	4651	CA	ASN	H	197	12.370	10.074	26.691	1.00	38.83	B	C
  ATOM	4652	CB	ASN	H	197	11.043	9.417	26.318	1.00	20.00	B	C
  ATOM	4653	CG	ASN	H	197	9.848	10.251	26.729	1.00	20.00	B	C
  ATOM	4654	OD1	ASN	H	197	9.957	11.129	27.585	1.00	20.00	B	O
  ATOM	4655	ND2	ASN	H	197	8.722	10.042	26.059	1.00	20.00	B	N
  ATOM	4656	C	ASN	H	197	13.492	9.042	26.685	1.00	39.90	B	C
  ATOM	4657	O	ASN	H	197	14.026	8.687	27.735	1.00	39.04	B	O
  ATOM	4658	N	TYR	H	198	13.871	8.590	25.495	1.00	35.09	B	N
  ATOM	4659	CA	TYR	H	198	14.992	7.672	25.355	1.00	41.03	B	C
  ATOM	4660	CB	TYR	H	198	15.246	7.355	23.882	1.00	20.00	B	C
  ATOM	4661	CG	TYR	H	198	14.109	6.617	23.218	1.00	20.00	B	C
  ATOM	4662	CD1	TYR	H	198	14.014	5.235	23.294	1.00	20.00	B	C
  ATOM	4663	CE1	TYR	H	198	12.963	4.558	22.712	1.00	20.00	B	C
  ATOM	4664	CZ	TYR	H	198	11.999	5.265	22.024	1.00	20.00	B	C
  ATOM	4665	OH	TYR	H	198	10.967	4.598	21.403	1.00	20.00	B	O
  ATOM	4666	CE2	TYR	H	198	12.073	6.638	21.934	1.00	20.00	B	C
  ATOM	4667	CD2	TYR	H	198	13.120	7.305	22.533	1.00	20.00	B	C
  ATOM	4668	C	TYR	H	198	16.252	8.234	26.002	1.00	43.65	B	C
  ATOM	4669	O	TYR	H	198	16.940	7.533	26.744	1.00	52.37	B	O
  ATOM	4670	N	ILE	H	199	16.464	9.537	25.831	1.00	35.86	B	N
  ATOM	4671	CA	ILE	H	199	17.634	10.219	26.386	1.00	45.39	B	C
  ATOM	4672	CB	ILE	H	199	17.722	11.682	25.904	1.00	20.00	B	C
  ATOM	4673	CG1	ILE	H	199	18.102	11.741	24.425	1.00	20.00	B	C
  ATOM	4674	CD1	ILE	H	199	18.674	13.078	24.004	1.00	20.00	B	C
  ATOM	4675	CG2	ILE	H	199	18.730	12.457	26.735	1.00	20.00	B	C
  ATOM	4676	C	ILE	H	199	17.639	10.200	27.912	1.00	37.89	B	C
  ATOM	4677	O	ILE	H	199	18.667	9.941	28.538	1.00	45.28	B	O
  ATOM	4678	N	ASP	H	200	16.492	10.508	28.505	1.00	37.36	B	N
  ATOM	4679	CA	ASP	H	200	16.368	10.551	29.954	1.00	46.66	B	C
  ATOM	4680	CB	ASP	H	200	14.992	11.080	30.354	1.00	20.00	B	C
  ATOM	4681	CG	ASP	H	200	14.837	12.564	30.083	1.00	20.00	B	C
  ATOM	4682	OD1	ASP	H	200	15.826	13.308	30.264	1.00	20.00	B	O
  ATOM	4683	OD2	ASP	H	200	13.718	12.992	29.721	1.00	20.00	B	O
  ATOM	4684	C	ASP	H	200	16.600	9.181	30.581	1.00	51.05	B	C
  ATOM	4685	O	ASP	H	200	16.986	9.081	31.745	1.00	57.39	B	O
  ATOM	4686	N	LYS	H	201	16.346	8.129	29.810	1.00	57.68	B	N
  ATOM	4687	CA	LYS	H	201	16.517	6.766	30.299	1.00	44.02	B	C
  ATOM	4688	CB	LYS	H	201	15.747	5.778	29.423	1.00	20.00	B	C
  ATOM	4689	CG	LYS	H	201	14.242	5.854	29.602	1.00	20.00	B	C
  ATOM	4690	CD	LYS	H	201	13.531	4.795	28.781	1.00	20.00	B	C
  ATOM	4691	CE	LYS	H	201	12.030	5.042	28.737	1.00	20.00	B	C
  ATOM	4692	NZ	LYS	H	201	11.346	4.192	27.722	1.00	20.00	B	N
  ATOM	4693	C	LYS	H	201	17.985	6.366	30.373	1.00	43.56	B	C
  ATOM	4694	O	LYS	H	201	18.348	5.447	31.105	1.00	51.34	B	O
  ATOM	4695	N	GLN	H	202	18.832	7.074	29.633	1.00	46.06	B	N
  ATOM	4696	CA	GLN	H	202	20.216	6.648	29.445	1.00	44.95	B	C
  ATOM	4697	CB	GLN	H	202	20.507	6.398	27.963	1.00	20.00	B	C
  ATOM	4698	CG	GLN	H	202	19.685	5.270	27.351	1.00	20.00	B	C
  ATOM	4699	CD	GLN	H	202	19.894	5.134	25.853	1.00	20.00	B	C
  ATOM	4700	OE1	GLN	H	202	20.323	6.075	25.184	1.00	20.00	B	O
  ATOM	4701	NE2	GLN	H	202	19.513	3.984	25.309	1.00	20.00	B	N
  ATOM	4702	C	GLN	H	202	21.245	7.616	30.044	1.00	42.35	B	C
  ATOM	4703	O	GLN	H	202	22.376	7.224	30.335	1.00	47.00	B	O
  ATOM	4704	N	LEU	H	203	20.852	8.874	30.228	1.00	49.55	B	N
  ATOM	4705	CA	LEU	H	203	21.762	9.902	30.735	1.00	50.77	B	C
  ATOM	4706	CB	LEU	H	203	21.119	11.283	30.618	1.00	20.00	B	C
  ATOM	4707	CG	LEU	H	203	20.836	11.775	29.202	1.00	20.00	B	C
  ATOM	4708	CD1	LEU	H	203	20.093	13.100	29.256	1.00	20.00	B	C
  ATOM	4709	CD2	LEU	H	203	22.134	11.910	28.422	1.00	20.00	B	C
  ATOM	4710	C	LEU	H	203	22.148	9.656	32.190	1.00	52.51	B	C
  ATOM	4711	O	LEU	H	203	21.273	9.564	33.050	1.00	46.02	B	O
  ATOM	4712	N	LEU	H	204	23.439	9.786	32.490	1.00	51.45	B	N
  ATOM	4713	CA	LEU	H	204	23.928	9.661	33.865	1.00	58.44	B	C
  ATOM	4714	CB	LEU	H	204	25.423	9.333	33.885	1.00	20.00	B	C
  ATOM	4715	CG	LEU	H	204	25.848	7.919	33.484	1.00	20.00	B	C
  ATOM	4716	CD1	LEU	H	204	27.346	7.764	33.658	1.00	20.00	B	C
  ATOM	4717	CD2	LEU	H	204	25.112	6.874	34.306	1.00	20.00	B	C
  ATOM	4718	C	LEU	H	204	23.661	10.930	34.667	1.00	54.99	B	C
  ATOM	4719	O	LEU	H	204	23.740	12.035	34.131	1.00	55.13	B	O
  ATOM	4720	N	PRO	H	205	23.414	10.775	35.977	1.00	58.64	B	N
  ATOM	4721	CA	PRO	H	205	22.981	11.935	36.734	1.00	52.19	B	C
  ATOM	4722	CB	PRO	H	205	22.776	11.363	38.137	1.00	20.00	B	C
  ATOM	4723	CG	PRO	H	205	23.735	10.190	38.219	1.00	20.00	B	C
  ATOM	4724	CD	PRO	H	205	24.191	9.850	36.818	1.00	20.00	B	C
  ATOM	4725	C	PRO	H	205	24.112	12.948	36.754	1.00	54.30	B	C
  ATOM	4726	O	PRO	H	205	23.898	14.128	37.030	1.00	70.22	B	O
  ATOM	4727	N	ILE	H	206	25.316	12.460	36.481	1.00	62.70	B	N
  ATOM	4728	CA	ILE	H	206	26.487	13.308	36.354	1.00	68.19	B	C
  ATOM	4729	CB	ILE	H	206	27.225	13.445	37.696	1.00	20.00	B	C
  ATOM	4730	CG1	ILE	H	206	26.350	14.186	38.709	1.00	20.00	B	C
  ATOM	4731	CD1	ILE	H	206	26.843	14.078	40.136	1.00	20.00	B	C
  ATOM	4732	CG2	ILE	H	206	28.553	14.161	37.505	1.00	20.00	B	C
  ATOM	4733	C	ILE	H	206	27.439	12.723	35.321	1.00	62.35	B	C
  ATOM	4734	O	ILE	H	206	27.594	11.505	35.221	1.00	67.16	B	O
  ATOM	4735	N	VAL	H	207	28.023	13.596	34.510	1.00	52.22	B	N
  ATOM	4736	CA	VAL	H	207	28.952	13.168	33.480	1.00	51.31	B	C
  ATOM	4737	CB	VAL	H	207	28.568	13.742	32.111	1.00	20.00	B	C
  ATOM	4738	CG1	VAL	H	207	29.545	13.261	31.047	1.00	20.00	B	C
  ATOM	4739	CG2	VAL	H	207	27.136	13.356	31.758	1.00	20.00	B	C
  ATOM	4740	C	VAL	H	207	30.378	13.582	33.821	1.00	62.09	B	C
  ATOM	4741	O	VAL	H	207	30.751	14.746	33.673	1.00	58.88	B	O
  ATOM	4742	N	ASN	H	208	31.140	12.641	34.367	1.00	71.72	B	N
  ATOM	4743	CA	ASN	H	208	32.533	12.886	34.707	1.00	70.92	B	C
  ATOM	4744	CB	ASN	H	208	32.855	12.307	36.086	1.00	20.00	B	C
  ATOM	4745	CG	ASN	H	208	32.187	13.074	37.209	1.00	20.00	B	C
  ATOM	4746	OD1	ASN	H	208	31.862	14.252	37.065	1.00	20.00	B	O
  ATOM	4747	ND2	ASN	H	208	31.993	12.411	38.344	1.00	20.00	B	N
  ATOM	4748	C	ASN	H	208	33.484	12.312	33.665	1.00	63.05	B	C
  ATOM	4749	O	ASN	H	208	33.051	11.778	32.645	1.00	61.34	B	O
  ATOM	4750	N	LYS	H	209	34.776	12.337	33.979	1.00	68.91	B	N
  ATOM	4751	CA	LYS	H	209	35.811	11.927	33.037	1.00	59.11	B	C
  ATOM	4752	CB	LYS	H	209	37.190	12.378	33.528	1.00	20.00	B	C
  ATOM	4753	CG	LYS	H	209	37.362	13.888	33.639	1.00	20.00	B	C
  ATOM	4754	CD	LYS	H	209	38.689	14.243	34.302	1.00	20.00	B	C
  ATOM	4755	CE	LYS	H	209	38.914	15.748	34.344	1.00	20.00	B	C
  ATOM	4756	NZ	LYS	H	209	40.286	16.091	34.815	1.00	20.00	B	N
  ATOM	4757	C	LYS	H	209	35.810	10.415	32.817	1.00	50.69	B	C
  ATOM	4758	O	LYS	H	209	36.500	9.910	31.932	1.00	51.01	B	O
  ATOM	4759	N	GLN	H	210	35.116	9.691	33.689	1.00	44.68	B	N
  ATOM	4760	CA	GLN	H	210	34.957	8.249	33.528	1.00	49.52	B	C
  ATOM	4761	CB	GLN	H	210	34.767	7.581	34.890	1.00	20.00	B	C
  ATOM	4762	CG	GLN	H	210	35.976	7.671	35.803	1.00	20.00	B	C
  ATOM	4763	CD	GLN	H	210	35.727	7.036	37.156	1.00	20.00	B	C
  ATOM	4764	OE1	GLN	H	210	34.591	6.983	37.629	1.00	20.00	B	O
  ATOM	4765	NE2	GLN	H	210	36.792	6.571	37.798	1.00	20.00	B	N
  ATOM	4766	C	GLN	H	210	33.765	7.937	32.632	1.00	62.08	B	C
  ATOM	4767	O	GLN	H	210	33.906	7.310	31.580	1.00	80.43	B	O
  ATOM	4768	N	SER	H	211	32.599	8.424	33.040	1.00	58.92	B	N
  ATOM	4769	CA	SER	H	211	31.384	8.297	32.251	1.00	47.88	B	C
  ATOM	4770	CB	SER	H	211	30.270	9.156	32.857	1.00	20.00	B	C
  ATOM	4771	OG	SER	H	211	30.733	10.462	33.169	1.00	20.00	B	O
  ATOM	4772	C	SER	H	211	31.609	8.665	30.783	1.00	57.32	B	C
  ATOM	4773	O	SER	H	211	31.138	7.967	29.884	1.00	50.74	B	O
  ATOM	4774	N	CYS	H	212	32.412	9.699	30.545	1.00	44.34	B	N
  ATOM	4775	CA	CYS	H	212	32.520	10.292	29.213	1.00	57.52	B	C
  ATOM	4776	CB	CYS	H	212	33.762	11.204	29.075	1.00	20.00	B	C
  ATOM	4777	SG	CYS	H	212	33.808	12.659	30.229	1.00	20.00	B	S
  ATOM	4778	C	CYS	H	212	32.395	9.264	28.073	1.00	60.91	B	C
  ATOM	4779	O	CYS	H	212	31.468	9.353	27.272	1.00	52.17	B	O
  ATOM	4780	N	SER	H	213	33.381	8.374	27.965	1.00	21.55	B	N
  ATOM	4781	CA	SER	H	213	33.462	7.484	26.814	1.00	21.67	B	C
  ATOM	4782	CB	SER	H	213	34.765	6.678	26.855	1.00	21.81	B	C
  ATOM	4783	OG	SER	H	213	35.892	7.530	26.960	1.00	23.00	B	O
  ATOM	4784	C	SER	H	213	32.284	6.537	26.686	1.00	21.45	B	C
  ATOM	4785	O	SER	H	213	31.711	6.410	25.603	1.00	21.98	B	O
  ATOM	4786	N	ILE	H	214	31.895	5.885	27.776	1.00	20.90	B	N
  ATOM	4787	CA	ILE	H	214	30.691	5.081	27.699	1.00	20.45	B	C
  ATOM	4788	CB	ILE	H	214	30.475	4.234	28.960	1.00	20.53	B	C
  ATOM	4789	CG1	ILE	H	214	31.411	3.025	28.946	1.00	20.46	B	C
  ATOM	4790	CD1	ILE	H	214	31.049	1.951	29.952	1.00	21.75	B	C
  ATOM	4791	CG2	ILE	H	214	29.021	3.787	29.052	1.00	20.34	B	C
  ATOM	4792	C	ILE	H	214	29.526	6.035	27.523	1.00	20.15	B	C
  ATOM	4793	O	ILE	H	214	28.694	5.870	26.631	1.00	19.91	B	O
  ATOM	4794	N	SER	H	215	29.528	7.080	28.346	1.00	19.84	B	N
  ATOM	4795	CA	SER	H	215	28.475	8.080	28.330	1.00	19.58	B	C
  ATOM	4796	CB	SER	H	215	28.663	9.070	29.478	1.00	19.76	B	C
  ATOM	4797	OG	SER	H	215	27.637	10.048	29.470	1.00	19.97	B	O
  ATOM	4798	C	SER	H	215	28.460	8.825	27.017	1.00	19.34	B	C
  ATOM	4799	O	SER	H	215	27.406	9.053	26.446	1.00	19.54	B	O
  ATOM	4800	N	ASN	H	216	29.638	9.187	26.527	1.00	18.80	B	N
  ATOM	4801	CA	ASN	H	216	29.724	9.885	25.258	1.00	18.36	B	C
  ATOM	4802	CB	ASN	H	216	31.156	10.336	24.972	1.00	18.41	B	C
  ATOM	4803	CG	ASN	H	216	31.647	11.377	25.959	1.00	19.55	B	C
  ATOM	4804	OD1	ASN	H	216	31.028	12.428	26.133	1.00	20.52	B	O
  ATOM	4805	ND2	ASN	H	216	32.779	11.100	26.597	1.00	20.43	B	N
  ATOM	4806	C	ASN	H	216	29.211	9.010	24.129	1.00	17.78	B	C
  ATOM	4807	O	ASN	H	216	28.481	9.479	23.255	1.00	17.91	B	O
  ATOM	4808	N	ILE	H	217	29.570	7.730	24.150	1.00	17.02	B	N
  ATOM	4809	CA	ILE	H	217	29.110	6.845	23.095	1.00	16.60	B	C
  ATOM	4810	CB	ILE	H	217	29.718	5.439	23.210	1.00	16.46	B	C
  ATOM	4811	CG1	ILE	H	217	31.093	5.403	22.540	1.00	16.26	B	C
  ATOM	4812	CD1	ILE	H	217	31.610	4.001	22.276	1.00	16.44	B	C
  ATOM	4813	CG2	ILE	H	217	28.791	4.408	22.591	1.00	16.70	B	C
  ATOM	4814	C	ILE	H	217	27.599	6.750	23.148	1.00	16.73	B	C
  ATOM	4815	O	ILE	H	217	26.923	6.809	22.116	1.00	16.80	B	O
  ATOM	4816	N	GLU	H	218	27.064	6.639	24.360	1.00	17.02	B	N
  ATOM	4817	CA	GLU	H	218	25.631	6.500	24.526	1.00	17.70	B	C
  ATOM	4818	CB	GLU	H	218	25.266	6.321	26.000	1.00	18.20	B	C
  ATOM	4819	CG	GLU	H	218	25.955	5.155	26.685	1.00	21.31	B	C
  ATOM	4820	CD	GLU	H	218	25.270	4.774	27.986	1.00	25.72	B	C
  ATOM	4821	OE1	GLU	H	218	25.558	5.409	29.023	1.00	26.96	B	O
  ATOM	4822	OE2	GLU	H	218	24.447	3.835	27.975	1.00	27.07	B	O
  ATOM	4823	C	GLU	H	218	24.951	7.742	23.995	1.00	17.29	B	C
  ATOM	4824	O	GLU	H	218	23.942	7.660	23.312	1.00	17.62	B	O
  ATOM	4825	N	THR	H	219	25.482	8.931	24.255	1.00	16.62	B	N
  ATOM	4826	CA	THR	H	219	24.786	10.141	23.789	1.00	15.95	B	C
  ATOM	4827	CB	THR	H	219	25.475	11.413	24.325	1.00	15.95	B	C
  ATOM	4828	OG1	THR	H	219	25.394	11.438	25.756	1.00	15.63	B	O
  ATOM	4829	CG2	THR	H	219	24.814	12.661	23.759	1.00	15.97	B	C
  ATOM	4830	C	THR	H	219	24.646	10.261	22.254	1.00	15.64	B	C
  ATOM	4831	O	THR	H	219	23.557	10.569	21.720	1.00	15.93	B	O
  ATOM	4832	N	VAL	H		220	25.737	9.974	21.550	1.00	14.98	B	N
  ATOM	4833	CA	VAL	H	220	25.773	10.074	20.093	1.00	14.51	B	C
  ATOM	4834	CB	VAL	H	220	27.177	9.738	19.559	1.00	14.29	B	C
  ATOM	4835	CG1	VAL	H	220	27.191	9.771	18.041	1.00	14.24	B	C
  ATOM	4836	CG2	VAL	H	220	28.213	10.693	20.137	1.00	14.10	B	C
  ATOM	4837	C	VAL	H	220	24.779	9.088	19.498	1.00	14.64	B	C
  ATOM	4838	O	VAL	H	220	24.030	9.390	18.544	1.00	14.79	B	O
  ATOM	4839	N	ILE	H	221	24.762	7.904	20.097	1.00	14.43	B	N
  ATOM	4840	CA	ILE	H	221	23.860	6.856	19.674	1.00	14.36	B	C
  ATOM	4841	CB	ILE	H	221	24.067	5.569	20.487	1.00	14.03	B	C
  ATOM	4842	CG1	ILE	H	221	25.394	4.909	20.110	1.00	13.72	B	C
  ATOM	4843	CD1	ILE	H	221	25.493	4.526	18.649	1.00	14.17	B	C
  ATOM	4844	CG2	ILE	H	221	22.908	4.611	20.267	1.00	13.91	B	C
  ATOM	4845	C	ILE	H	221	22.443	7.351	19.869	1.00	14.82	B	C
  ATOM	4846	O	ILE	H	221	21.589	7.132	19.023	1.00	14.82	B	O
  ATOM	4847	N	GLU	H	222	22.195	8.039	20.978	1.00	15.51	B	N
  ATOM	4848	CA	GLU	H	222	20.857	8.551	21.246	1.00	16.52	B	C
  ATOM	4849	CB	GLU	H	222	20.733	9.113	22.663	1.00	16.80	B	C
  ATOM	4850	CG	GLU	H	222	20.725	8.043	23.747	1.00	19.14	B	C
  ATOM	4851	CD	GLU	H	222	19.637	8.267	24.780	1.00	22.62	B	C
  ATOM	4852	OE1	GLU	H	222	19.965	8.662	25.919	1.00	24.35	B	O
  ATOM	4853	OE2	GLU	H	222	18.453	8.039	24.454	1.00	23.98	B	O
  ATOM	4854	C	GLU	H	222	20.400	9.566	20.199	1.00	16.65	B	C
  ATOM	4855	O	GLU	H	222	19.255	9.541	19.792	1.00	16.95	B	O
  ATOM	4856	N	PHE	H	223	21.292	10.444	19.752	1.00	16.70	B	N
  ATOM	4857	CA	PHE	H	223	20.971	11.413	18.690	1.00	16.95	B	C
  ATOM	4858	CB	PHE	H	223	22.259	12.227	18.509	1.00	16.85	B	C
  ATOM	4859	CG	PHE	H	223	22.154	13.406	17.593	1.00	17.23	B	C
  ATOM	4860	CD1	PHE	H	223	21.522	14.570	17.995	1.00	17.98	B	C
  ATOM	4861	CE1	PHE	H	223	21.467	15.667	17.155	1.00	18.28	B	C
  ATOM	4862	CZ	PHE	H	223	22.071	15.616	15.914	1.00	18.19	B	C
  ATOM	4863	CE2	PHE	H	223	22.726	14.469	15.516	1.00	18.14	B	C
  ATOM	4864	CD2	PHE	H	223	22.776	13.380	16.357	1.00	17.75	B	C
  ATOM	4865	C	PHE	H	223	20.601	10.675	17.371	1.00	17.28	B	C
  ATOM	4866	O	PHE	H	223	19.564	10.951	16.650	1.00	17.17	B	O
  ATOM	4867	N	GLN	H	224	21.422	9.671	17.091	1.00	17.62	B	N
  ATOM	4868	CA	GLN	H	224	21.209	8.880	15.894	1.00	18.16	B	C
  ATOM	4869	CB	GLN	H	224	22.390	7.930	15.652	1.00	18.51	B	C
  ATOM	4870	CG	GLN	H	224	23.751	8.594	15.888	1.00	20.06	B	C
  ATOM	4871	CD	GLN	H	224	24.867	8.009	15.039	1.00	22.03	B	C
  ATOM	4872	OE1	GLN	H	224	24.920	6.800	14.806	1.00	22.15	B	O
  ATOM	4873	NE2	GLN	H	224	25.783	8.864	14.595	1.00	22.11	B	N
  ATOM	4874	C	GLN	H	224	19.855	8.158	15.956	1.00	18.04	B	C
  ATOM	4875	O	GLN	H	224	19.196	7.981	14.932	1.00	18.17	B	O
  ATOM	4876	N	GLN	H	225	19.488	7.701	17.156	1.00	17.90	B	N
  ATOM	4877	CA	GLN	H	225	18.192	7.079	17.492	1.00	17.95	B	C
  ATOM	4878	CB	GLN	H	225	18.271	6.408	18.861	1.00	18.13	B	C
  ATOM	4879	CG	GLN	H	225	19.251	5.257	18.893	1.00	19.04	B	C
  ATOM	4880	CD	GLN	H	225	18.854	4.196	19.891	1.00	21.22	B	C
  ATOM	4881	OE1	GLN	H	225	17.834	4.321	20.569	1.00	22.55	B	O
  ATOM	4882	NE2	GLN	H	225	19.651	3.142	19.985	1.00	22.48	B	N
  ATOM	4883	C	GLN	H	225	16.993	8.032	17.430	1.00	17.84	B	C
  ATOM	4884	O	GLN	H	225	15.872	7.657	17.090	1.00	17.71	B	O
  ATOM	4885	N	LYS	H	226	18.593	9.729	17.758	1.00	17.95	B	N
  ATOM	4886	CA	LYS	H	226	17.704	10.870	17.777	1.00	18.00	B	C
  ATOM	4887	CB	LYS	H	226	18.471	12.167	18.045	1.00	18.21	B	C
  ATOM	4888	CG	LYS	H	226	19.258	12.240	19.342	1.00	18.50	B	C
  ATOM	4889	CD	LYS	H	226	18.743	13.353	20.242	1.00	19.87	B	C
  ATOM	4890	CE	LYS	H	226	19.762	13.696	21.316	1.00	21.36	B	C
  ATOM	4891	NZ	LYS	H	226	19.374	14.909	22.085	1.00	21.83	B	N
  ATOM	4892	C	LYS	H	226	17.251	10.914	16.350	1.00	17.84	B	C
  ATOM	4893	O	LYS	H	226	16.195	11.458	16.046	1.00	17.94	B	O
  ATOM	4894	N	ASN	H	227	18.025	10.304	15.460	1.00	17.70	B	N
  ATOM	4895	CA	ASN	H	227	17.467	10.197	14.086	1.00	17.66	B	C
  ATOM	4896	CB	ASN	H	227	18.366	9.273	13.270	1.00	17.36	B	C
  ATOM	4897	CG	ASN	H	227	19.700	9.884	12.927	1.00	17.40	B	C
  ATOM	4898	OD1	ASN	H	227	20.438	9.337	12.107	1.00	17.84	B	O
  ATOM	4899	ND2	ASN	H	227	20.025	11.011	13.545	1.00	17.22	B	N
  ATOM	4900	C	ASN	H	227	16.016	9.596	13.857	1.00	17.76	B	C
  ATOM	4901	O	ASN	H	227	15.214	10.239	13.175	1.00	17.92	B	O
  ATOM	4902	N	ASN	H	228	15.655	8.431	14.418	1.00	17.78	B	N
  ATOM	4903	CA	ASN	H	228	14.290	7.922	14.435	1.00	17.59	B	C
  ATOM	4904	CB	ASN	H	228	14.003	7.185	15.743	1.00	17.89	B	C
  ATOM	4905	CG	ASN	H	228	14.845	5.934	15.903	1.00	18.43	B	C
  ATOM	4906	OD1	ASN	H	228	15.432	5.698	16.959	1.00	18.74	B	O
  ATOM	4907	ND2	ASN	H	228	14.908	5.124	14.852	1.00	18.61	B	N
  ATOM	4908	C	ASN	H	228	13.335	9.091	14.265	1.00	17.09	B	C
  ATOM	4909	O	ASN	H	228	12.380	9.032	13.490	1.00	17.17	B	O
  ATOM	4910	N	ARG	H	229	13.267	9.880	15.306	1.00	16.33	B	N
  ATOM	4911	CA	ARG	H	229	12.252	10.885	15.298	1.00	15.76	B	C
  ATOM	4912	CB	ARG	H	229	11.906	11.215	16.758	1.00	15.70	B	C
  ATOM	4913	CG	ARG	H	229	11.667	9.916	17.580	1.00	14.99	B	C
  ATOM	4914	CD	ARG	H	229	11.240	10.128	19.039	1.00	15.33	B	C
  ATOM	4915	NE	ARG	H	229	12.372	10.516	19.868	1.00	15.59	B	N
  ATOM	4916	CZ	ARG	H	229	13.209	9.663	20.448	1.00	15.85	B	C
  ATOM	4917	NH1	ARG	H	229	13.045	8.350	20.313	1.00	16.20	B	N
  ATOM	4918	NH2	ARG	H	229	14.216	10.134	21.168	1.00	16.63	B	N
  ATOM	4919	C	ARG	H	229	12.960	11.937	14.490	1.00	15.62	B	C
  ATOM	4920	O	ARG	H	229	12.436	12.586	13.561	1.00	15.73	B	O
  ATOM	4921	N	LEU	H	230	14.249	11.935	14.783	1.00	15.46	B	N
  ATOM	4922	CA	LEU	H	230	15.146	12.972	14.402	1.00	15.22	B	C
  ATOM	4923	CB	LEU	H	230	16.334	12.863	15.348	1.00	15.08	B	C
  ATOM	4924	CG	LEU	H		230	17.100	14.054	15.896	1.00	14.70	B	C
  ATOM	4925	CD1	LEU	H	230	16.465	14.590	17.171	1.00	15.19	B	C
  ATOM	4926	CD2	LEU	H	230	18.500	13.564	16.165	1.00	15.46	B	C
  ATOM	4927	C	LEU	H		230	15.658	12.853	12.989	1.00	15.31	B	C
  ATOM	4928	O	LEU	H		230	15.224	13.608	12.133	1.00	15.46	B	O
  ATOM	4929	N	LEU	H	231	16.533	11.890	12.727	1.00	15.48	B	N
  ATOM	4930	CA	LEU	H	231	17.158	11.825	11.423	1.00	15.75	B	C
  ATOM	4931	CB	LEU	H	231	18.215	10.722	11.423	1.00	15.90	B	C
  ATOM	4932	CG	LEU	H	231	19.366	10.875	12.416	1.00	16.63	B	C
  ATOM	4933	CD1	LEU	H	231	20.443	9.836	12.133	1.00	18.45	B	C
  ATOM	4934	CD2	LEU	H	231	19.953	12.276	12.366	1.00	16.67	B	C
  ATOM	4935	C	LEU	H	231	16.139	11.575	10.324	1.00	15.76	B	C
  ATOM	4936	O	LEU	H	231	16.121	12.269	9.309	1.00	15.84	B	O
  ATOM	4937	N	GLU	H	232	15.249	10.617	10.561	1.00	15.71	B	N
  ATOM	4938	CA	GLU	H	232	14.200	10.308	9.607	1.00	15.93	B	C
  ATOM	4939	CB	GLU	H	232	13.470	9.012	10.001	1.00	16.15	B	C
  ATOM	4940	CG	GLU	H	232	14.389	7.801	10.158	1.00	18.59	B	C
  ATOM	4941	CD	GLU	H	232	14.567	6.988	8.876	1.00	21.47	B	C
  ATOM	4942	OE1	GLU	H	232	13.976	7.355	7.839	1.00	22.14	B	O
  ATOM	4943	OE2	GLU	H	232	15.298	5.973	8.907	1.00	23.34	B	O
  ATOM	4944	C	GLU	H	232	13.241	11.482	9.456	1.00	15.45	B	C
  ATOM	4945	O	GLU	H	232	12.881	11.860	8.328	1.00	15.95	B	O
  ATOM	4946	N	ILE	H	233	12.855	12.113	10.564	1.00	14.54	B	N
  ATOM	4947	CA	ILE	H	233	11.941	13.221	10.375	1.00	13.69	B	C
  ATOM	4948	CB	ILE	H	233	11.444	13.775	11.699	1.00	13.63	B	C
  ATOM	4949	CG1	ILE	H	233	10.497	12.763	12.326	1.00	13.58	B	C
  ATOM	4950	CD1	ILE	H	233	9.817	13.280	13.532	1.00	13.55	B	C
  ATOM	4951	CG2	ILE	H	233	10.682	15.070	11.490	1.00	13.88	B	C
  ATOM	4952	C	ILE	H	233	12.605	14.309	9.526	1.00	13.28	B	C
  ATOM	4953	O	ILE	H	233	11.972	14.914	8.653	1.00	13.04	B	O
  ATOM	4954	N	THR	H	234	13.888	14.544	9.773	1.00	13.18	B	N
  ATOM	4955	CA	THR	H	234	14.620	15.575	9.063	1.00	13.39	B	C
  ATOM	4956	CB	THR	H	234	16.082	15.655	9.574	1.00	13.21	B	C
  ATOM	4957	OG1	THR	H	234	16.099	15.927	10.978	1.00	13.15	B	O
  ATOM	4958	CG2	THR	H	234	16.870	16.740	8.846	1.00	13.22	B	C
  ATOM	4959	C	THR	H	234	14.686	15.273	7.577	1.00	13.76	B	C
  ATOM	4960	O	THR	H	234	14.434	16.152	6.738	1.00	13.95	B	O
  ATOM	4961	N	ARG	H	235	14.994	14.024	7.240	1.00	14.26	B	N
  ATOM	4962	CA	ARG	H	235	15.119	13.686	5.831	1.00	14.92	B	C
  ATOM	4963	CB	ARG	H	235	15.574	12.242	5.661	1.00	15.30	B	C
  ATOM	4964	CG	ARG	H	235	14.532	11.325	5.054	1.00	16.27	B	C
  ATOM	4965	CD	ARG	H	235	14.829	9.882	5.408	1.00	18.52	B	C
  ATOM	4966	NE	ARG	H	235	16.234	9.676	5.746	1.00	17.86	B	N
  ATOM	4967	CZ	ARG	H	235	17.190	9.425	4.858	1.00	16.91	B	C
  ATOM	4968	NH1	ARG	H	235	16.898	9.354	3.566	1.00	16.59	B	N
  ATOM	4969	NH2	ARG	H	235	18.438	9.249	5.267	1.00	16.86	B	N
  ATOM	4970	C	ARG	H	235	13.766	13.887	5.176	1.00	15.05	B	C
  ATOM	4971	O	ARG	H	235	13.663	14.432	4.073	1.00	15.15	B	O
  ATOM	4972	N	GLU	H	236	12.727	13.474	5.894	1.00	15.18	B	N
  ATOM	4973	CA	GLU	H	236	11.375	13.527	5.376	1.00	15.24	B	C
  ATOM	4974	CB	GLU	H	236	10.415	12.920	6.403	1.00	15.69	B	C
  ATOM	4975	CG	GLU	H	236	9.176	12.265	5.822	1.00	18.22	B	C
  ATOM	4976	CD	GLU	H	236	8.355	11.543	6.875	1.00	21.59	B	C
  ATOM	4977	OE1	GLU	H	236	7.200	11.178	6.581	1.00	24.41	B	O
  ATOM	4978	OE2	GLU	H	236	8.857	11.345	8.000	1.00	21.59	B	O
  ATOM	4979	C	GLU	H	236	10.987	14.971	5.073	1.00	14.61	B	C
  ATOM	4980	O	GLU	H	236	10.396	15.253	4.031	1.00	14.82	B	O
  ATOM	4981	N	PHE	H	237	11.333	15.877	5.985	1.00	14.05	B	N
  ATOM	4982	CA	PHE	H	237	11.053	17.296	5.809	1.00	13.84	B	C
  ATOM	4983	CB	PHE	H	237	11.316	18.065	7.105	1.00	14.04	B	C
  ATOM	4984	CG	PHE	H	237	10.142	18.087	8.038	1.00	14.84	B	C
  ATOM	4985	CD1	PHE	H	237	10.224	17.516	9.297	1.00	15.30	B	C
  ATOM	4986	CE1	PHE	H	237	9.142	17.542	10.153	1.00	15.15	B	C
  ATOM	4987	CZ	PHE	H	237	7.961	18.135	9.755	1.00	15.19	B	C
  ATOM	4988	CE2	PHE	H	237	7.864	18.704	8.502	1.00	15.02	B	C
  ATOM	4989	CD2	PHE	H	237	8.949	18.677	7.651	1.00	15.03	B	C
  ATOM	4990	C	PHE	H	237	11.830	17.909	4.654	1.00	13.51	B	C
  ATOM	4991	O	PHE	H	237	11.293	18.687	3.866	1.00	13.43	B	O
  ATOM	4992	N	SER	H	238	13.100	17.534	4.554	1.00	13.11	B	N
  ATOM	4993	CA	SER	H	238	13.972	18.065	3.516	1.00	12.82	B	C
  ATOM	4994	CB	SER	H	238	15.404	17.546	3.691	1.00	12.86	B	C
  ATOM	4995	OG	SER	H	238	15.976	17.981	4.916	1.00	12.76	B	O
  ATOM	4996	C	SER	H	238	13.411	17.654	2.164	1.00	12.69	B	C
  ATOM	4997	O	SER	H	238	13.437	18.425	1.202	1.00	12.63	B	O
  ATOM	4998	N	VAL	H	239	12.910	16.426	2.107	1.00	12.59	B	N
  ATOM	4999	CA	VAL	H	239	12.361	15.865	0.883	1.00	12.80	B	C
  ATOM	5000	CB	VAL	H	239	12.065	14.358	1.041	1.00	12.71	B	C
  ATOM	5001	CG1	VAL	H	239	11.359	13.819	−0.193	1.00	13.63	B	C
  ATOM	5002	CG2	VAL	H	239	13.349	13.588	1.316	1.00	13.57	B	C
  ATOM	5003	C	VAL	H	239	11.094	16.596	0.443	1.00	12.94	B	C
  ATOM	5004	O	VAL	H	239	10.722	16.546	−0.728	1.00	13.10	B	O
  ATOM	5005	N	ASN	H	240	10.430	17.274	1.372	1.00	4.15	B	N
  ATOM	5006	CA	ASN	H	240	9.074	17.741	1.109	1.00	4.33	B	C
  ATOM	5007	CB	ASN	H	240	8.110	17.268	2.199	1.00	4.59	B	C
  ATOM	5008	CG	ASN	H	240	7.810	15.784	2.106	1.00	5.36	B	C
  ATOM	5009	OD1	ASN	H	240	7.128	15.331	1.188	1.00	6.27	B	O
  ATOM	5010	ND2	ASN	H	240	8.343	15.016	3.047	1.00	7.15	B	N
  ATOM	5011	C	ASN	H	240	8.924	19.242	0.853	1.00	4.19	B	C
  ATOM	5012	O	ASN	H	240	7.843	19.707	0.490	1.00	4.19	B	O
  ATOM	5013	N	ALA	H	241	10.014	19.990	0.995	1.00	3.93	B	N
  ATOM	5014	CA	ALA	H	241	9.948	21.447	0.930	1.00	3.90	B	C
  ATOM	5015	CB	ALA	H	241	9.784	21.908	−0.511	1.00	3.86	B	C
  ATOM	5016	C	ALA	H	241	8.812	21.985	1.798	1.00	4.22	B	C
  ATOM	5017	O	ALA	H	241	7.932	22.697	1.314	1.00	4.47	B	O
  ATOM	5018	N	GLY	H	242	8.772	21.540	3.049	1.00	4.53	B	N
  ATOM	5019	CA	GLY	H	242	8.055	22.258	4.097	1.00	4.65	B	C
  ATOM	5020	C	GLY	H	242	6.563	21.980	4.122	1.00	4.67	B	C
  ATOM	5021	O	GLY	H	242	5.792	22.759	4.683	1.00	5.27	B	O
  ATOM	5022	N	VAL	H	243	6.159	20.841	3.570	1.00	4.37	B	N
  ATOM	5023	CA	VAL	H	243	4.755	20.449	3.577	1.00	4.32	B	C
  ATOM	5024	CB	VAL	H	243	3.961	21.182	2.477	1.00	3.99	B	C
  ATOM	5025	CG1	VAL	H	243	2.519	21.398	2.915	1.00	4.22	B	C
  ATOM	5026	CG2	VAL	H	243	4.629	22.508	2.131	1.00	3.85	B	C
  ATOM	5027	C	VAL	H	243	4.595	18.943	3.393	1.00	4.61	B	C
  ATOM	5028	O	VAL	H	243	5.201	18.350	2.501	1.00	4.89	B	O
  ATOM	5029	N	THR	H	244	3.764	18.333	4.231	1.00	4.95	B	N
  ATOM	5030	CA	THR	H	244	3.600	16.886	4.220	1.00	5.71	B	C
  ATOM	5031	CB	THR	H	244	4.318	16.226	5.410	1.00	6.11	B	C
  ATOM	5032	OG1	THR	H	244	5.051	17.217	6.140	1.00	7.17	B	O
  ATOM	5033	CG2	THR	H	244	5.273	15.147	4.925	1.00	7.55	B	C
  ATOM	5034	C	THR	H	244	2.129	16.505	4.268	1.00	5.61	B	C
  ATOM	5035	O	THR	H	244	1.359	17.073	5.042	1.00	5.85	B	O
  ATOM	5036	N	THR	H	245	1.786	15.428	3.575	1.00	5.53	B	N
  ATOM	5037	CA	THR	H	245	0.617	14.647	3.939	1.00	5.81	B	C
  ATOM	5038	CB	THR	H	245	−0.404	14.592	2.788	1.00	6.13	B	C
  ATOM	5039	OG1	THR	H	245	−0.888	15.915	2.517	1.00	8.11	B	O
  ATOM	5040	CG2	THR	H	245	−1.577	13.695	3.154	1.00	6.63	B	C
  ATOM	5041	C	THR	H	245	1.032	13.245	4.370	1.00	5.73	B	C
  ATOM	5042	O	THR	H	245	2.189	12.861	4.202	1.00	5.86	B	O
  ATOM	5043	N	PRO	H	246	0.060	12.433	4.804	1.00	5.68	B	N
  ATOM	5044	CA	PRO	H	246	0.078	11.993	6.186	1.00	5.11	B	C
  ATOM	5045	CB	PRO	H	246	0.753	10.626	6.084	1.00	5.19	B	C
  ATOM	5046	CG	PRO	H	246	0.360	10.124	4.675	1.00	5.90	B	C
  ATOM	5047	CD	PRO	H	246	−0.256	11.297	3.926	1.00	6.36	B	C
  ATOM	5048	C	PRO	H	246	0.830	12.916	7.140	1.00	4.85	B	C
  ATOM	5049	O	PRO	H	246	1.927	13.379	6.825	1.00	5.25	B	O
  ATOM	5050	N	VAL	H	247	0.144	13.323	8.205	1.00	4.35	B	N
  ATOM	5051	CA	VAL	H	247	0.792	13.950	9.347	1.00	3.82	B	C
  ATOM	5052	CB	VAL	H	247	−0.198	14.817	10.157	1.00	3.52	B	C
  ATOM	5053	CG1	VAL	H	247	0.558	15.754	11.087	1.00	3.62	B	C
  ATOM	5054	CG2	VAL	H	247	−1.091	15.615	9.217	1.00	3.60	B	C
  ATOM	5055	C	VAL	H	247	1.447	12.899	10.242	1.00	3.69	B	C
  ATOM	5056	O	VAL	H	247	0.761	12.124	10.913	1.00	3.36	B	O
  ATOM	5057	N	SER	H	248	2.748	12.721	10.040	1.00	3.72	B	N
  ATOM	5058	CA	SER	H	248	3.496	11.654	10.686	1.00	3.96	B	C
  ATOM	5059	CB	SER	H	248	4.995	11.840	10.451	1.00	4.07	B	C
  ATOM	5060	OG	SER	H	248	5.525	12.834	11.310	1.00	4.13	B	O
  ATOM	5061	C	SER	H	248	3.211	11.615	12.180	1.00	4.35	B	C
  ATOM	5062	O	SER	H	248	2.890	12.635	12.788	1.00	4.36	B	O
  ATOM	5063	N	THR	H	249	3.458	10.460	12.784	1.00	4.53	B	N
  ATOM	5064	CA	THR	H	249	3.489	10.350	14.231	1.00	4.61	B	C
  ATOM	5065	CB	THR	H	249	3.682	8.893	14.677	1.00	4.70	B	C
  ATOM	5066	OG1	THR	H	249	5.018	8.473	14.374	1.00	5.42	B	O
  ATOM	5067	CG2	THR	H	249	2.695	7.984	13.961	1.00	4.88	B	C
  ATOM	5068	C	THR	H	249	4.589	11.215	14.839	1.00	4.47	B	C
  ATOM	5069	O	THR	H	249	4.570	11.491	16.039	1.00	4.74	B	O
  ATOM	5070	N	TYR	H	250	5.518	11.684	14.009	1.00	4.32	B	N
  ATOM	5071	CA	TYR	H	250	6.544	12.619	14.475	1.00	4.42	B	C
  ATOM	5072	CB	TYR	H	250	7.811	12.531	13.625	1.00	4.91	B	C
  ATOM	5073	CG	TYR	H	250	8.409	11.148	13.525	1.00	6.81	B	C
  ATOM	5074	CD1	TYR	H	250	8.844	10.657	12.302	1.00	8.89	B	C
  ATOM	5075	CE1	TYR	H	250	9.480	9.437	12.205	1.00	10.73	B	C
  ATOM	5076	CZ	TYR	H	250	9.685	8.685	13.341	1.00	12.28	B	C
  ATOM	5077	OH	TYR	H	250	10.305	7.460	13.251	1.00	12.24	B	O
  ATOM	5078	CE2	TYR	H	250	9.284	9.161	14.571	1.00	12.15	B	C
  ATOM	5079	CD2	TYR	H	250	8.689	10.405	14.662	1.00	9.81	B	C
  ATOM	5080	C	TYR	H	250	6.053	14.064	14.516	1.00	4.21	B	C
  ATOM	5081	O	TYR	H	250	6.596	14.883	15.259	1.00	4.20	B	O
  ATOM	5082	N	MET	H	251	5.148	14.413	13.605	1.00	4.14	B	N
  ATOM	5083	CA	MET	H	251	4.517	15.732	13.632	1.00	4.15	B	C
  ATOM	5084	CB	MET	H	251	3.798	16.014	12.313	1.00	4.14	B	C
  ATOM	5085	CG	MET	H	251	4.720	16.097	11.115	1.00	4.51	B	C
  ATOM	5086	SD	MET	H	251	5.733	17.587	11.115	1.00	3.81	B	S
  ATOM	5087	CE	MET	H	251	5.601	18.077	9.395	1.00	4.55	B	C
  ATOM	5088	C	MET	H	251	3.519	15.806	14.775	1.00	4.13	B	C
  ATOM	5089	O	MET	H	251	3.510	16.759	15.555	1.00	4.24	B	O
  ATOM	5090	N	LEU	H	252	2.692	14.773	14.874	1.00	4.23	B	N
  ATOM	5091	CA	LEU	H	252	1.708	14.681	15.934	1.00	4.22	B	C
  ATOM	5092	CB	LEU	H	252	0.302	14.881	15.369	1.00	4.14	B	C
  ATOM	5093	CG	LEU	H	252	−0.295	16.282	15.515	1.00	4.05	B	C
  ATOM	5094	CD1	LEU	H	252	−1.813	16.216	15.561	1.00	5.22	B	C
  ATOM	5095	CD2	LEU	H	252	0.245	16.972	16.756	1.00	6.20	B	C
  ATOM	5096	C	LEU	H	252	1.818	13.314	16.589	1.00	4.62	B	C
  ATOM	5097	O	LEU	H	252	1.906	12.295	15.903	1.00	4.97	B	O
  ATOM	5098	N	THR	H	253	1.986	13.314	17.906	1.00	4.90	B	N
  ATOM	5099	CA	THR	H	253	1.718	12.126	18.704	1.00	5.57	B	C
  ATOM	5100	CB	THR	H	253	2.147	12.323	20.168	1.00	5.55	B	C
  ATOM	5101	OG1	THR	H	253	3.369	13.068	20.214	1.00	6.43	B	O
  ATOM	5102	CG2	THR	H	253	2.362	10.978	20.842	1.00	6.28	B	C
  ATOM	5103	C	THR	H	253	0.235	11.775	18.673	1.00	6.03	B	C
  ATOM	5104	O	THR	H	253	−0.621	12.663	18.679	1.00	6.68	B	O
  ATOM	5105	N	ASN	H	254	−0.066	10.483	18.746	1.00	6.39	B	N
  ATOM	5106	CA	ASN	H	254	−1.396	10.040	19.141	1.00	6.79	B	C
  ATOM	5107	CB	ASN	H	254	−1.375	8.564	19.534	1.00	6.85	B	C
  ATOM	5108	CG	ASN	H	254	−2.758	7.954	19.571	1.00	6.81	B	C
  ATOM	5109	OD1	ASN	H	254	−3.395	7.771	18.534	1.00	7.67	B	O
  ATOM	5110	ND2	ASN	H	254	−3.252	7.682	20.773	1.00	6.19	B	N
  ATOM	5111	C	ASN	H	254	−1.956	10.882	20.284	1.00	7.08	B	C
  ATOM	5112	O	ASN	H	254	−2.968	11.565	20.125	1.00	6.90	B	O
  ATOM	5113	N	SER	H	255	−1.282	10.843	21.430	1.00	7.21	B	N
  ATOM	5114	CA	SER	H	255	−1.689	11.633	22.588	1.00	7.37	B	C
  ATOM	5115	CB	SER	H	255	−0.561	11.714	23.619	1.00	8.09	B	C
  ATOM	5116	OG	SER	H	255	0.228	10.539	23.617	1.00	10.47	B	O
  ATOM	5117	C	SER	H	255	−2.102	13.036	22.163	1.00	6.82	B	C
  ATOM	5118	O	SER	H	255	−3.192	13.499	22.496	1.00	6.99	B	O
  ATOM	5119	N	GLU	H	256	−1.229	13.704	21.415	1.00	6.17	B	N
  ATOM	5120	CA	GLU	H	256	−1.485	15.072	20.981	1.00	6.13	B	C
  ATOM	5121	CB	GLU	H	256	−0.274	15.644	20.243	1.00	6.22	B	C
  ATOM	5122	CG	GLU	H	256	0.847	16.110	21.152	1.00	8.41	B	C
  ATOM	5123	CD	GLU	H	256	2.209	15.761	20.596	1.00	10.26	B	C
  ATOM	5124	OE1	GLU	H	256	2.292	15.472	19.384	1.00	11.90	B	O
  ATOM	5125	OE2	GLU	H	256	3.162	15.626	21.392	1.00	9.55	B	O
  ATOM	5126	C	GLU	H	256	−2.706	15.126	20.079	1.00	5.76	B	C
  ATOM	5127	O	GLU	H	256	−3.684	15.810	20.380	1.00	5.93	B	O
  ATOM	5128	N	LEU	H	257	−2.633	14.420	18.956	1.00	5.67	B	N
  ATOM	5129	CA	LEU	H	257	−3.729	14.411	18.002	1.00	5.37	B	C
  ATOM	5130	CB	LEU	H	257	−3.543	13.299	16.970	1.00	5.03	B	C
  ATOM	5131	CG	LEU	H	257	−4.781	13.003	16.121	1.00	3.65	B	C
  ATOM	5132	CD1	LEU	H	257	−5.114	14.184	15.222	1.00	2.00	B	C
  ATOM	5133	CD2	LEU	H	257	−4.592	11.737	15.305	1.00	2.14	B	C
  ATOM	5134	C	LEU	H	257	−5.050	14.223	18.732	1.00	5.64	B	C
  ATOM	5135	O	LEU	H	257	−6.020	14.934	18.475	1.00	5.81	B	O
  ATOM	5136	N	LEU	H	258	−5.061	13.300	19.687	1.00	5.75	B	N
  ATOM	5137	CA	LEU	H	258	−6.297	12.905	20.344	1.00	5.91	B	C
  ATOM	5138	CB	LEU	H	258	−6.063	11.693	21.242	1.00	6.10	B	C
  ATOM	5139	CG	LEU	H	258	−6.438	10.358	20.605	1.00	5.75	B	C
  ATOM	5140	CD1	LEU	H	258	−5.970	9.206	21.477	1.00	6.33	B	C
  ATOM	5141	CD2	LEU	H	258	−7.939	10.287	20.372	1.00	7.33	B	C
  ATOM	5142	C	LEU	H	258	−6.908	14.049	21.142	1.00	6.03	B	C
  ATOM	5143	O	LEU	H	258	−8.113	14.290	21.071	1.00	5.73	B	O
  ATOM	5144	N	SER	H	259	−6.076	14.745	21.910	1.00	6.47	B	N
  ATOM	5145	CA	SER	H	259	−6.537	15.883	22.695	1.00	6.95	B	C
  ATOM	5146	CB	SER	H	259	−5.521	16.237	23.784	1.00	7.05	B	C
  ATOM	5147	OG	SER	H	259	−4.695	17.317	23.383	1.00	6.86	B	O
  ATOM	5148	C	SER	H	259	−6.782	17.086	21.795	1.00	6.74	B	C
  ATOM	5149	O	SER	H	259	−7.592	17.959	22.110	1.00	6.86	B	O
  ATOM	5150	N	LEU	H	260	−6.074	17.125	20.670	1.00	6.31	B	N
  ATOM	5151	CA	LEU	H	260	−6.295	18.149	19.657	1.00	6.09	B	C
  ATOM	5152	CB	LEU	H	260	−5.239	18.052	18.552	1.00	6.09	B	C
  ATOM	5153	CG	LEU	H	260	−4.235	19.203	18.446	1.00	6.24	B	C
  ATOM	5154	CD1	LEU	H	260	−3.350	19.030	17.222	1.00	6.53	B	C
  ATOM	5155	CD2	LEU	H	260	−4.944	20.549	18.407	1.00	5.98	B	C
  ATOM	5156	C	LEU	H	260	−7.692	18.026	19.056	1.00	6.25	B	C
  ATOM	5157	O	LEU	H	260	−8.428	19.010	18.963	1.00	6.37	B	O
  ATOM	5158	N	ILE	H	261	−8.024	16.825	18.596	1.00	6.63	B	N
  ATOM	5159	CA	ILE	H	261	−9.395	16.490	18.245	1.00	7.19	B	C
  ATOM	5160	CB	ILE	H	261	−9.568	14.975	18.078	1.00	7.09	B	C
  ATOM	5161	CG1	ILE	H	261	−9.037	14.528	16.715	1.00	7.46	B	C
  ATOM	5162	CD1	ILE	H	261	−8.132	13.315	16.782	1.00	8.38	B	C
  ATOM	5163	CG2	ILE	H	261	−11.024	14.579	18.262	1.00	6.61	B	C
  ATOM	5164	C	ILE	H	261	−10.352	16.980	19.322	1.00	8.01	B	C
  ATOM	5165	O	ILE	H	261	−11.255	17.770	19.051	1.00	8.26	B	O
  ATOM	5166	N	ASN	H	262	−10.081	16.586	20.560	1.00	9.05	B	N
  ATOM	5167	CA	ASN	H	262	−10.896	17.006	21.689	1.00	9.88	B	C
  ATOM	5168	CB	ASN	H	262	−10.175	16.714	23.001	1.00	9.99	B	C
  ATOM	5169	CG	ASN	H	262	−11.127	16.353	24.111	1.00	11.16	B	C
  ATOM	5170	OD1	ASN	H	262	−12.345	16.408	23.936	1.00	12.70	B	O
  ATOM	5171	ND2	ASN	H	262	−10.583	15.980	25.264	1.00	13.20	B	N
  ATOM	5172	C	ASN	H	262	−11.258	18.482	21.619	1.00	10.17	B	C
  ATOM	5173	O	ASN	H	262	−12.347	18.887	22.027	1.00	10.52	B	O
  ATOM	5174	N	ASP	H	263	−10.310	19.289	21.158	1.00	10.62	B	N
  ATOM	5175	CA	ASP	H	263	−10.437	20.734	21.247	1.00	11.02	B	C
  ATOM	5176	CB	ASP	H	263	−9.057	21.395	21.285	1.00	11.49	B	C
  ATOM	5177	CG	ASP	H	263	−9.138	22.905	21.401	1.00	12.80	B	C
  ATOM	5178	OD1	ASP	H	263	−9.972	23.401	22.188	1.00	14.72	B	O
  ATOM	5179	OD2	ASP	H	263	−8.354	23.596	20.717	1.00	13.88	B	O
  ATOM	5180	C	ASP	H	263	−11.261	21.293	20.091	1.00	10.92	B	C
  ATOM	5181	O	ASP	H	263	−11.686	22.446	20.130	1.00	10.96	B	O
  ATOM	5182	N	MET	H	264	−11.539	20.453	19.097	1.00	10.91	B	N
  ATOM	5183	CA	MET	H	264	−12.199	20.904	17.871	1.00	10.78	B	C
  ATOM	5184	CB	MET	H	264	−12.091	19.840	16.770	1.00	10.51	B	C
  ATOM	5185	CG	MET	H	264	−10.664	19.427	16.425	1.00	11.26	B	C
  ATOM	5186	SD	MET	H	264	−10.510	18.571	14.840	1.00	12.70	B	S
  ATOM	5187	CE	MET	H	264	−11.715	17.260	15.021	1.00	13.92	B	C
  ATOM	5188	C	MET	H	264	−13.666	21.240	18.119	1.00	10.85	B	C
  ATOM	5189	O	MET	H	264	−14.369	20.489	18.795	1.00	11.03	B	O
  ATOM	5190	N	PRO	H	265	−14.146	22.342	17.517	1.00	10.88	B	N
  ATOM	5191	CA	PRO	H	265	−15.522	22.802	17.700	1.00	11.09	B	C
  ATOM	5192	CB	PRO	H	265	−15.515	24.198	17.060	1.00	11.28	B	C
  ATOM	5193	CG	PRO	H	265	−14.322	24.216	16.167	1.00	11.24	B	C
  ATOM	5194	CD	PRO	H	265	−13.313	23.356	16.849	1.00	11.03	B	C
  ATOM	5195	C	PRO	H	265	−16.546	21.912	17.003	1.00	11.19	B	C
  ATOM	5196	O	PRO	H	265	−17.320	22.395	16.177	1.00	11.47	B	O
  ATOM	5197	N	ILE	H	266	−16.633	20.655	17.425	1.00	11.54	B	N
  ATOM	5198	CA	ILE	H	266	−17.540	19.710	16.786	1.00	12.15	B	C
  ATOM	5199	CB	ILE	H	266	−16.794	18.757	15.828	1.00	12.22	B	C
  ATOM	5200	CG1	ILE	H	266	−15.611	18.088	16.536	1.00	12.53	B	C
  ATOM	5201	CD1	ILE	H	266	−15.044	16.895	15.789	1.00	12.40	B	C
  ATOM	5202	CG2	ILE	H	266	−16.337	19.507	14.588	1.00	12.74	B	C
  ATOM	5203	C	ILE	H	266	−18.353	18.902	17.793	1.00	12.29	B	C
  ATOM	5204	O	ILE	H	266	−18.068	18.913	18.991	1.00	12.36	B	O
  ATOM	5205	N	THR	H	267	−19.404	18.252	17.303	1.00	12.29	B	N
  ATOM	5206	CA	THR	H	267	−20.248	17.414	18.148	1.00	12.43	B	C
  ATOM	5207	CB	THR	H	267	−21.440	16.821	17.366	1.00	12.40	B	C
  ATOM	5208	OG1	THR	H	267	−21.299	15.397	17.278	1.00	13.21	B	O
  ATOM	5209	CG2	THR	H	267	−21.509	17.405	15.968	1.00	12.21	B	C
  ATOM	5210	C	THR	H	267	−19.432	16.276	18.740	1.00	12.37	B	C
  ATOM	5211	O	THR	H	267	−18.246	16.134	18.446	1.00	12.29	B	O
  ATOM	5212	N	ASN	H	268	−20.058	15.490	19.605	1.00	12.47	B	N
  ATOM	5213	CA	ASN	H	268	−19.325	14.501	20.377	1.00	12.57	B	C
  ATOM	5214	CB	ASN	H	268	−20.025	14.218	21.701	1.00	12.69	B	C
  ATOM	5215	CG	ASN	H	268	−19.461	15.041	22.832	1.00	13.65	B	C
  ATOM	5216	OD1	ASN	H	268	−18.555	15.851	22.631	1.00	14.37	B	O
  ATOM	5217	ND2	ASN	H	268	−20.005	14.856	24.028	1.00	15.74	B	N
  ATOM	5218	C	ASN	H	268	−19.084	13.207	19.621	1.00	12.43	B	C
  ATOM	5219	O	ASN	H	268	−18.038	12.576	19.776	1.00	12.51	B	O
  ATOM	5220	N	ASP	H	269	−20.107	12.747	18.912	1.00	12.34	B	N
  ATOM	5221	CA	ASP	H	269	−19.976	11.565	18.077	1.00	12.33	B	C
  ATOM	5222	CB	ASP	H	269	−21.316	11.222	17.431	1.00	12.89	B	C
  ATOM	5223	CG	ASP	H	269	−22.404	10.959	18.456	1.00	14.84	B	C
  ATOM	5224	OD1	ASP	H	269	−22.145	10.209	19.422	1.00	16.90	B	O
  ATOM	5225	OD2	ASP	H	269	−23.487	11.573	18.346	1.00	17.65	B	O
  ATOM	5226	C	ASP	H	269	−18.916	11.780	17.008	1.00	11.60	B	C
  ATOM	5227	O	ASP	H	269	−18.073	10.914	16.774	1.00	11.65	B	O
  ATOM	5228	N	GLN	H	270	−18.924	12.963	16.405	1.00	10.62	B	N
  ATOM	5229	CA	GLN	H	270	−17.836	13.371	15.530	1.00	10.01	B	C
  ATOM	5230	CB	GLN	H	270	−17.958	14.851	15.179	1.00	10.18	B	C
  ATOM	5231	CG	GLN	H	270	−17.709	15.154	13.718	1.00	11.49	B	C
  ATOM	5232	CD	GLN	H	270	−18.572	16.286	13.213	1.00	14.38	B	C
  ATOM	5233	OE1	GLN	H	270	−18.076	17.238	12.613	1.00	16.38	B	O
  ATOM	5234	NE2	GLN	H	270	−19.866	16.215	13.496	1.00	15.41	B	N
  ATOM	5235	C	GLN	H	270	−16.486	13.097	16.181	1.00	9.48	B	C
  ATOM	5236	O	GLN	H	270	−15.696	12.296	15.682	1.00	9.12	B	O
  ATOM	5237	N	LYS	H	271	−16.229	13.763	17.301	1.00	9.19	B	N
  ATOM	5238	CA	LYS	H	271	−15.004	13.541	18.056	1.00	8.89	B	C
  ATOM	5239	CB	LYS	H	271	−15.117	14.168	19.448	1.00	8.52	B	C
  ATOM	5240	CG	LYS	H	271	−15.410	15.663	19.445	1.00	9.14	B	C
  ATOM	5241	CD	LYS	H	271	−14.906	16.316	20.726	1.00	10.72	B	C
  ATOM	5242	CE	LYS	H	271	−15.469	17.718	20.900	1.00	10.79	B	C
  ATOM	5243	NZ	LYS	H	271	−14.711	18.506	21.916	1.00	9.77	B	N
  ATOM	5244	C	LYS	H	271	−14.699	12.049	18.175	1.00	8.83	B	C
  ATOM	5245	O	LYS	H	271	−13.660	11.577	17.713	1.00	9.05	B	O
  ATOM	5246	N	LYS	H	272	−15.653	11.301	18.719	1.00	8.65	B	N
  ATOM	5247	CA	LYS	H	272	−15.485	9.868	18.899	1.00	8.50	B	C
  ATOM	5248	CB	LYS	H	272	−16.766	9.240	19.443	1.00	9.14	B	C
  ATOM	5249	CG	LYS	H	272	−16.762	7.726	19.397	1.00	11.58	B	C
  ATOM	5250	CD	LYS	H	272	−18.170	7.167	19.394	1.00	15.78	B	C
  ATOM	5251	CE	LYS	H	272	−18.151	5.663	19.599	1.00	17.65	B	C
  ATOM	5252	NZ	LYS	H	272	−19.476	5.142	20.029	1.00	19.68	B	N
  ATOM	5253	C	LYS	H	272	−15.083	9.185	17.598	1.00	7.88	B	C
  ATOM	5254	O	LYS	H	272	−14.195	8.332	17.587	1.00	8.12	B	O
  ATOM	5255	N	LEU	H	273	−15.787	9.506	16.517	1.00	6.95	B	N
  ATOM	5256	CA	LEU	H	273	−15.456	8.939	15.216	1.00	5.70	B	C
  ATOM	5257	CB	LEU	H	273	−16.366	9.490	14.116	1.00	5.85	B	C
  ATOM	5258	CG	LEU	H	273	−15.894	9.204	12.683	1.00	4.65	B	C
  ATOM	5259	CD1	LEU	H	273	−16.085	7.739	12.312	1.00	4.57	B	C
  ATOM	5260	CD2	LEU	H	273	−16.569	10.123	11.669	1.00	3.69	B	C
  ATOM	5261	C	LEU	H	273	−14.005	9.227	14.877	1.00	5.14	B	C
  ATOM	5262	O	LEU	H	273	−13.188	8.312	14.795	1.00	5.25	B	O
  ATOM	5263	N	MET	H	274	−13.668	10.509	14.775	1.00	4.52	B	N
  ATOM	5264	CA	MET	H	274	−12.307	10.910	14.447	1.00	4.59	B	C
  ATOM	5265	CB	MET	H	274	−12.147	12.429	14.567	1.00	4.35	B	C
  ATOM	5266	CG	MET	H	274	−12.862	13.219	13.479	1.00	4.50	B	C
  ATOM	5267	SD	MET	H	274	−12.547	14.992	13.574	1.00	5.51	B	S
  ATOM	5268	CE	MET	H	274	−10.875	15.078	12.935	1.00	5.26	B	C
  ATOM	5269	C	MET	H	274	−11.294	10.190	15.334	1.00	5.18	B	C
  ATOM	5270	O	MET	H	274	−10.272	9.703	14.851	1.00	5.61	B	O
  ATOM	5271	N	SER	H	275	−11.652	10.006	16.601	1.00	5.89	B	N
  ATOM	5272	CA	SER	H	275	−10.752	9.380	17.557	1.00	6.18	B	C
  ATOM	5273	CB	SER	H	275	−11.237	9.619	18.988	1.00	6.33	B	C
  ATOM	5274	OG	SER	H	275	−11.029	10.969	19.371	1.00	5.91	B	O
  ATOM	5275	C	SER	H	275	−10.583	7.886	17.288	1.00	6.58	B	C
  ATOM	5276	O	SER	H	275	−9.519	7.318	17.544	1.00	7.03	B	O
  ATOM	5277	N	ASN	H	276	−11.607	7.268	16.711	1.00	7.07	B	N
  ATOM	5278	CA	ASN	H	276	−11.525	5.857	16.369	1.00	7.86	B	C
  ATOM	5279	CB	ASN	H	276	−12.885	5.173	16.547	1.00	8.34	B	C
  ATOM	5280	CG	ASN	H	276	−13.108	4.676	17.969	1.00	9.77	B	C
  ATOM	5281	OD1	ASN	H	276	−12.161	4.307	18.666	1.00	11.84	B	O
  ATOM	5282	ND2	ASN	H	276	−14.351	4.748	18.433	1.00	11.15	B	N
  ATOM	5283	C	ASN	H	276	−10.959	5.605	14.971	1.00	7.71	B	C
  ATOM	5284	O	ASN	H	276	−10.950	4.468	14.498	1.00	7.84	B	O
  ATOM	5285	N	ASN	H	277	−10.386	6.643	14.363	1.00	7.77	B	N
  ATOM	5286	CA	ASN	H	277	−10.026	6.597	12.943	1.00	7.85	B	C
  ATOM	5287	CB	ASN	H	277	−11.209	7.021	12.073	1.00	7.58	B	C
  ATOM	5288	CG	ASN	H	277	−12.197	5.896	11.846	1.00	8.29	B	C
  ATOM	5289	OD1	ASN	H	277	−11.932	4.970	11.079	1.00	9.04	B	O
  ATOM	5290	ND2	ASN	H	277	−13.297	5.915	12.592	1.00	9.57	B	N
  ATOM	5291	C	ASN	H	277	−8.792	7.426	12.585	1.00	7.86	B	C
  ATOM	5292	O	ASN	H	277	−8.614	7.832	11.435	1.00	7.85	B	O
  ATOM	5293	N	VAL	H	278	−8.003	7.754	13.603	1.00	7.67	B	N
  ATOM	5294	CA	VAL	H	278	−6.682	8.354	13.425	1.00	7.77	B	C
  ATOM	5295	CB	VAL	H	278	−5.677	7.813	14.459	1.00	7.98	B	C
  ATOM	5296	CG1	VAL	H	278	−5.763	8.615	15.749	1.00	7.21	B	C
  ATOM	5297	CG2	VAL	H	278	−5.932	6.336	14.725	1.00	8.99	B	C
  ATOM	5298	C	VAL	H	278	−6.095	8.223	12.019	1.00	7.76	B	C
  ATOM	5299	O	VAL	H	278	−5.641	9.211	11.444	1.00	7.84	B	O
  ATOM	5300	N	GLN	H	279	−5.935	6.989	11.553	1.00	7.47	B	N
  ATOM	5301	CA	GLN	H	279	−5.162	6.725	10.343	1.00	7.07	B	C
  ATOM	5302	CB	GLN	H	279	−5.291	5.256	9.938	1.00	7.62	B	C
  ATOM	5303	CG	GLN	H	279	−3.986	4.621	9.497	1.00	10.35	B	C
  ATOM	5304	CD	GLN	H	279	−4.194	3.335	8.725	1.00	13.70	B	C
  ATOM	5305	OE1	GLN	H	279	−5.319	2.986	8.367	1.00	15.06	B	O
  ATOM	5306	NE2	GLN	H	279	−3.105	2.622	8.460	1.00	13.97	B	N
  ATOM	5307	C	GLN	H	279	−5.610	7.621	9.192	1.00	6.02	B	C
  ATOM	5308	O	GLN	H	279	−4.795	8.297	8.563	1.00	5.45	B	O
  ATOM	5309	N	ILE	H	280	−6.881	7.492	8.829	1.00	5.25	B	N
  ATOM	5310	CA	ILE	H	280	−7.499	8.346	7.822	1.00	4.74	B	C
  ATOM	5311	CB	ILE	H	280	−9.022	8.133	7.775	1.00	4.58	B	C
  ATOM	5312	CG1	ILE	H	280	−9.349	6.641	7.685	1.00	4.16	B	C
  ATOM	5313	CD1	ILE	H	280	−8.986	6.014	6.357	1.00	3.88	B	C
  ATOM	5314	CG2	ILE	H	280	−9.636	8.897	6.612	1.00	3.92	B	C
  ATOM	5315	C	ILE	H	280	−7.225	9.818	8.101	1.00	4.43	B	C
  ATOM	5316	O	ILE	H	280	−6.655	10.522	7.268	1.00	4.39	B	O
  ATOM	5317	N	VAL	H	281	−7.745	10.301	9.224	1.00	4.05	B	N
  ATOM	5318	CA	VAL	H	281	−7.502	11.671	9.651	1.00	3.58	B	C
  ATOM	5319	CB	VAL	H	281	−7.705	11.833	11.170	1.00	3.13	B	C
  ATOM	5320	CG1	VAL	H	281	−7.901	13.299	11.526	1.00	2.34	B	C
  ATOM	5321	CG2	VAL	H	281	−8.890	11.002	11.638	1.00	2.21	B	C
  ATOM	5322	C	VAL	H	281	−6.089	12.110	9.280	1.00	3.96	B	C
  ATOM	5323	O	VAL	H	281	−5.905	13.063	8.522	1.00	4.15	B	O
  ATOM	5324	N	ARG	H	282	−5.096	11.377	9.777	1.00	4.23	B	N
  ATOM	5325	CA	ARG	H	282	−3.697	11.649	9.454	1.00	4.45	B	C
  ATOM	5326	CB	ARG	H	282	−2.799	10.506	9.941	1.00	3.96	B	C
  ATOM	5327	CG	ARG	H	282	−2.843	10.255	11.440	1.00	2.99	B	C
  ATOM	5328	CD	ARG	H	282	−1.441	10.173	12.028	1.00	2.28	B	C
  ATOM	5329	NE	ARG	H	282	−1.470	9.891	13.460	1.00	2.00	B	N
  ATOM	5330	CZ	ARG	H	282	−0.687	10.483	14.358	1.00	2.44	B	C
  ATOM	5331	NH1	ARG	H	282	0.219	11.371	13.970	1.00	2.04	B	N
  ATOM	5332	NH2	ARG	H	282	−0.770	10.140	15.636	1.00	3.44	B	N
  ATOM	5333	C	ARG	H	282	−3.530	11.813	7.953	1.00	5.32	B	C
  ATOM	5334	O	ARG	H	282	−2.952	12.793	7.482	1.00	5.95	B	O
  ATOM	5335	N	GLN	H	283	−3.946	10.791	7.214	1.00	5.50	B	N
  ATOM	5336	CA	GLN	H	283	−3.837	10.802	5.766	1.00	5.80	B	C
  ATOM	5337	CB	GLN	H	283	−4.404	9.511	5.178	1.00	6.19	B	C
  ATOM	5338	CG	GLN	H	283	−3.531	8.297	5.431	1.00	9.68	B	C
  ATOM	5339	CD	GLN	H	283	−4.248	6.994	5.156	1.00	13.92	B	C
  ATOM	5340	OE1	GLN	H	283	−5.408	6.984	4.745	1.00	16.20	B	O
  ATOM	5341	NE2	GLN	H	283	−3.549	5.883	5.354	1.00	14.17	B	N
  ATOM	5342	C	GLN	H	283	−4.552	12.008	5.175	1.00	5.44	B	C
  ATOM	5343	O	GLN	H	283	−4.187	12.493	4.104	1.00	5.43	B	O
  ATOM	5344	N	GLN	H	284	−5.532	12.527	5.905	1.00	5.26	B	N
  ATOM	5345	CA	GLN	H	284	−6.361	13.609	5.396	1.00	5.18	B	C
  ATOM	5346	CB	GLN	H	284	−7.799	13.451	5.877	1.00	5.32	B	C
  ATOM	5347	CG	GLN	H	284	−8.666	12.649	4.933	1.00	6.85	B	C
  ATOM	5348	CD	GLN	H	284	−10.091	12.547	5.415	1.00	9.21	B	C
  ATOM	5349	OE1	GLN	H	284	−10.340	12.297	6.595	1.00	9.74	B	O
  ATOM	5350	NE2	GLN	H	284	−11.034	12.860	4.537	1.00	9.79	B	N
  ATOM	5351	C	GLN	H	284	−5.817	14.967	5.813	1.00	4.67	B	C
  ATOM	5352	O	GLN	H	284	−6.336	16.006	5.406	1.00	4.19	B	O
  ATOM	5353	N	SER	H	285	−4.758	14.950	6.614	1.00	4.51	B	N
  ATOM	5354	CA	SER	H	285	−4.240	16.170	7.212	1.00	4.39	B	C
  ATOM	5355	CB	SER	H	285	−4.020	15.979	8.713	1.00	4.13	B	C
  ATOM	5356	OG	SER	H	285	−5.177	15.446	9.334	1.00	4.40	B	O
  ATOM	5357	C	SER	H	285	−2.943	16.598	6.540	1.00	4.44	B	C
  ATOM	5358	O	SER	H	285	−2.286	15.804	5.866	1.00	4.82	B	O
  ATOM	5359	N	TYR	H	286	−2.600	17.870	6.704	1.00	4.53	B	N
  ATOM	5360	CA	TYR	H	286	−1.328	18.388	6.228	1.00	4.80	B	C
  ATOM	5361	CB	TYR	H	286	−1.560	19.527	5.236	1.00	4.88	B	C
  ATOM	5362	CG	TYR	H	286	−2.163	19.083	3.923	1.00	5.68	B	C
  ATOM	5363	CD1	TYR	H	286	−3.448	18.558	3.868	1.00	7.34	B	C
  ATOM	5364	CE1	TYR	H	286	−4.003	18.153	2.668	1.00	9.02	B	C
  ATOM	5365	CZ	TYR	H	286	−3.279	18.287	1.502	1.00	9.40	B	C
  ATOM	5366	OH	TYR	H	286	−3.829	17.892	0.304	1.00	10.44	B	O
  ATOM	5367	CE2	TYR	H	286	−2.006	18.817	1.530	1.00	9.38	B	C
  ATOM	5368	CD2	TYR	H	286	−1.458	19.214	2.735	1.00	7.39	B	C
  ATOM	5369	C	TYR	H	286	−0.501	18.884	7.404	1.00	4.76	B	C
  ATOM	5370	O	TYR	H	286	−1.036	19.160	8.478	1.00	5.25	B	O
  ATOM	5371	N	SER	H	287	0.803	19.011	7.194	1.00	4.52	B	N
  ATOM	5372	CA	SER	H	287	1.649	19.738	8.125	1.00	4.45	B	C
  ATOM	5373	CB	SER	H	287	2.518	18.768	8.927	1.00	4.57	B	C
  ATOM	5374	OG	SER	H	287	3.602	19.441	9.544	1.00	4.38	B	O
  ATOM	5375	C	SER	H	287	2.515	20.758	7.396	1.00	4.61	B	C
  ATOM	5376	O	SER	H	287	3.264	20.409	6.483	1.00	4.40	B	O
  ATOM	5377	N	ILE	H	288	2.294	22.033	7.710	1.00	5.11	B	N
  ATOM	5378	CA	ILE	H	288	3.067	23.130	7.131	1.00	5.81	B	C
  ATOM	5379	CB	ILE	H	288	2.176	24.349	6.825	1.00	5.52	B	C
  ATOM	5380	CG1	ILE	H	288	0.730	23.913	6.578	1.00	5.47	B	C
  ATOM	5381	CD1	ILE	H	288	0.479	23.356	5.196	1.00	6.23	B	C
  ATOM	5382	CG2	ILE	H	288	2.733	25.142	5.651	1.00	6.22	B	C
  ATOM	5383	C	ILE	H	288	4.170	23.581	8.080	1.00	6.71	B	C
  ATOM	5384	O	ILE	H	288	3.902	23.948	9.224	1.00	7.30	B	O
  ATOM	5385	N	MET	H	289	5.380	23.699	7.548	1.00	7.71	B	N
  ATOM	5386	CA	MET	H	289	6.487	24.307	8.274	1.00	8.57	B	C
  ATOM	5387	CB	MET	H	289	7.781	24.096	7.492	1.00	8.71	B	C
  ATOM	5388	CG	MET	H	289	9.038	24.181	8.326	1.00	9.70	B	C
  ATOM	5389	SD	MET	H	289	10.511	24.120	7.292	1.00	12.59	B	S
  ATOM	5390	CE	MET	H	289	10.168	25.446	6.138	1.00	12.41	B	C
  ATOM	5391	C	MET	H	289	6.245	25.801	8.468	1.00	9.12	B	C
  ATOM	5392	O	MET	H	289	5.976	26.513	7.501	1.00	9.31	B	O
  ATOM	5393	N	SER	H	290	6.457	26.293	9.688	1.00	9.80	B	N
  ATOM	5394	CA	SER	H	290	6.140	27.688	10.021	1.00	10.49	B	C
  ATOM	5395	CB	SER	H	290	5.283	27.777	11.287	1.00	10.64	B	C
  ATOM	5396	OG	SER	H	290	4.906	29.117	11.560	1.00	11.99	B	O
  ATOM	5397	C	SER	H	290	7.372	28.582	10.146	1.00	10.75	B	C
  ATOM	5398	O	SER	H	290	7.635	29.401	9.265	1.00	10.89	B	O
  ATOM	5399	N	ILE	H	291	8.095	28.469	11.258	1.00	11.04	B	N
  ATOM	5400	CA	ILE	H	291	9.405	29.112	11.361	1.00	11.41	B	C
  ATOM	5401	CB	ILE	H	291	9.335	30.523	11.981	1.00	11.80	B	C
  ATOM	5402	CG1	ILE	H	291	8.071	30.680	12.828	1.00	11.81	B	C
  ATOM	5403	CD1	ILE	H	291	8.273	30.362	14.291	1.00	11.76	B	C
  ATOM	5404	CG2	ILE	H	291	9.390	31.586	10.891	1.00	12.39	B	C
  ATOM	5405	C	ILE	H	291	10.510	28.289	12.022	1.00	11.13	B	C
  ATOM	5406	O	ILE	H	291	10.337	27.742	13.111	1.00	10.55	B	O
  ATOM	5407	N	ILE	H	292	11.678	28.302	11.388	1.00	11.36	B	N
  ATOM	5408	CA	ILE	H	292	12.827	27.544	11.855	1.00	11.82	B	C
  ATOM	5409	CB	ILE	H	292	13.483	26.752	10.710	1.00	11.86	B	C
  ATOM	5410	CG1	ILE	H	292	12.770	27.030	9.386	1.00	13.42	B	C
  ATOM	5411	CD1	ILE	H	292	11.373	27.593	9.542	1.00	15.86	B	C
  ATOM	5412	CG2	ILE	H	292	13.500	25.262	11.022	1.00	10.85	B	C
  ATOM	5413	C	ILE	H	292	13.867	28.476	12.454	1.00	11.72	B	C
  ATOM	5414	O	ILE	H	292	14.414	29.343	11.771	1.00	11.28	B	O
  ATOM	5415	N	LYS	H	293	14.150	28.269	13.733	1.00	12.11	B	N
  ATOM	5416	CA	LYS	H	293	15.287	28.894	14.382	1.00	12.92	B	C
  ATOM	5417	CB	LYS	H	293	14.812	29.763	15.544	1.00	13.15	B	C
  ATOM	5418	CG	LYS	H	293	13.615	30.634	15.208	1.00	14.17	B	C
  ATOM	5419	CD	LYS	H	293	13.793	32.037	15.758	1.00	15.37	B	C
  ATOM	5420	CE	LYS	H	293	12.940	33.041	15.001	1.00	16.68	B	C
  ATOM	5421	NZ	LYS	H	293	13.111	34.421	15.532	1.00	18.18	B	N
  ATOM	5422	C	LYS	H	293	16.224	27.813	14.894	1.00	13.32	B	C
  ATOM	5423	O	LYS	H	293	15.800	26.689	15.167	1.00	13.17	B	O
  ATOM	5424	N	GLU	H	294	17.511	28.132	14.944	1.00	14.07	B	N
  ATOM	5425	CA	GLU	H	294	18.518	27.147	15.302	1.00	15.07	B	C
  ATOM	5426	CB	GLU	H	294	19.847	27.831	15.624	1.00	15.94	B	C
  ATOM	5427	CG	GLU	H	294	20.563	28.399	14.409	1.00	19.87	B	C
  ATOM	5428	CD	GLU	H	294	21.978	28.849	14.721	1.00	23.88	B	C
  ATOM	5429	OE1	GLU	H	294	22.830	27.983	15.010	1.00	23.75	B	O
  ATOM	5430	OE2	GLU	H	294	22.247	30.066	14.640	1.00	25.81	B	O
  ATOM	5431	C	GLU	H	294	18.056	26.299	16.482	1.00	14.40	B	C
  ATOM	5432	O	GLU	H	294	18.348	25.106	16.546	1.00	14.33	B	O
  ATOM	5433	N	GLU	H	295	17.279	26.904	17.378	1.00	13.97	B	N
  ATOM	5434	CA	GLU	H	295	16.914	26.255	18.635	1.00	13.84	B	C
  ATOM	5435	CB	GLU	H	295	17.570	26.953	19.830	1.00	14.67	B	C
  ATOM	5436	CG	GLU	H	295	18.047	28.366	19.550	1.00	17.56	B	C
  ATOM	5437	CD	GLU	H	295	16.928	29.281	19.096	1.00	21.41	B	C
  ATOM	5438	OE1	GLU	H	295	16.816	29.524	17.876	1.00	22.35	B	O
  ATOM	5439	OE2	GLU	H	295	16.190	29.795	19.962	1.00	23.20	B	O
  ATOM	5440	C	GLU	H	295	15.406	26.155	18.851	1.00	12.77	B	C
  ATOM	5441	O	GLU	H	295	14.956	25.743	19.919	1.00	12.58	B	O
  ATOM	5442	N	VAL	H	296	14.627	26.533	17.845	1.00	11.72	B	N
  ATOM	5443	CA	VAL	H	296	13.195	26.268	17.870	1.00	10.65	B	C
  ATOM	5444	CB	VAL	H	296	12.418	27.396	18.571	1.00	10.47	B	C
  ATOM	5445	CG1	VAL	H	296	10.974	26.983	18.804	1.00	9.77	B	C
  ATOM	5446	CG2	VAL	H	296	13.090	27.760	19.884	1.00	11.31	B	C
  ATOM	5447	C	VAL	H	296	12.632	26.053	16.473	1.00	10.26	B	C
  ATOM	5448	O	VAL	H	296	12.887	26.838	15.561	1.00	10.09	B	O
  ATOM	5449	N	LEU	H	297	11.781	25.042	16.345	1.00	9.77	B	N
  ATOM	5450	CA	LEU	H	297	11.034	24.815	15.119	1.00	8.97	B	C
  ATOM	5451	CB	LEU	H	297	11.386	23.448	14.534	1.00	8.64	B	C
  ATOM	5452	CG	LEU	H	297	10.442	22.948	13.442	1.00	9.01	B	C
  ATOM	5453	CD1	LEU	H	297	10.243	24.018	12.373	1.00	9.79	B	C
  ATOM	5454	CD2	LEU	H	297	10.960	21.648	12.834	1.00	9.43	B	C
  ATOM	5455	C	LEU	H	297	9.535	24.885	15.388	1.00	8.34	B	C
  ATOM	5456	O	LEU	H	297	9.006	24.129	16.205	1.00	8.64	B	O
  ATOM	5457	N	ALA	H	298	8.848	25.771	14.675	1.00	7.21	B	N
  ATOM	5458	CA	ALA	H	298	7.396	25.872	14.777	1.00	6.33	B	C
  ATOM	5459	CB	ALA	H	298	6.987	27.268	15.238	1.00	6.68	B	C
  ATOM	5460	C	ALA	H	298	6.749	25.537	13.441	1.00	5.85	B	C
  ATOM	5461	O	ALA	H	298	7.310	25.823	12.384	1.00	5.96	B	O
  ATOM	5462	N	TYR	H	299	5.653	24.793	13.492	1.00	5.28	B	N
  ATOM	5463	CA	TYR	H	299	4.928	24.443	12.282	1.00	4.63	B	C
  ATOM	5464	CB	TYR	H	299	5.468	23.142	11.691	1.00	4.36	B	C
  ATOM	5465	CG	TYR	H	299	5.432	21.978	12.652	1.00	4.34	B	C
  ATOM	5466	CD1	TYR	H	299	4.330	21.136	12.711	1.00	4.48	B	C
  ATOM	5467	CE1	TYR	H	299	4.299	20.061	13.578	1.00	4.55	B	C
  ATOM	5468	CZ	TYR	H	299	5.373	19.826	14.410	1.00	3.72	B	C
  ATOM	5469	OH	TYR	H	299	5.343	18.762	15.282	1.00	2.38	B	O
  ATOM	5470	CE2	TYR	H	299	6.475	20.651	14.374	1.00	4.13	B	C
  ATOM	5471	CD2	TYR	H	299	6.494	21.727	13.509	1.00	4.38	B	C
  ATOM	5472	C	TYR	H	299	3.443	24.308	12.563	1.00	4.32	B	C
  ATOM	5473	O	TYR	H	299	3.034	24.068	13.699	1.00	4.67	B	O
  ATOM	5474	N	VAL	H	300	2.638	24.454	11.519	1.00	3.87	B	N
  ATOM	5475	CA	VAL	H	300	1.193	24.395	11.664	1.00	3.57	B	C
  ATOM	5476	CB	VAL	H	300	0.501	25.518	10.873	1.00	3.52	B	C
  ATOM	5477	CG1	VAL	H	300	−0.990	25.241	10.751	1.00	3.44	B	C
  ATOM	5478	CG2	VAL	H	300	0.743	26.861	11.544	1.00	3.90	B	C
  ATOM	5479	C	VAL	H	300	0.654	23.049	11.203	1.00	3.53	B	C
  ATOM	5480	O	VAL	H	300	0.858	22.647	10.058	1.00	3.68	B	O
  ATOM	5481	N	VAL	H	301	−0.061	22.370	12.092	1.00	3.41	B	N
  ATOM	5482	CA	VAL	H	301	−0.857	21.216	11.704	1.00	3.36	B	C
  ATOM	5483	CB	VAL	H	301	−1.038	20.233	12.873	1.00	3.24	B	C
  ATOM	5484	CG1	VAL	H	301	−2.141	19.235	12.559	1.00	3.76	B	C
  ATOM	5485	CG2	VAL	H	301	0.270	19.516	13.169	1.00	3.10	B	C
  ATOM	5486	C	VAL	H	301	−2.223	21.641	11.183	1.00	3.48	B	C
  ATOM	5487	O	VAL	H	301	−2.772	22.661	11.602	1.00	3.92	B	O
  ATOM	5488	N	GLN	H	302	−2.766	20.845	10.270	1.00	3.21	B	N
  ATOM	5489	CA	GLN	H	302	−3.989	21.201	9.569	1.00	3.01	B	C
  ATOM	5490	CB	GLN	H	302	−3.662	21.767	8.188	1.00	3.24	B	C
  ATOM	5491	CG	GLN	H	302	−4.875	21.992	7.307	1.00	5.21	B	C
  ATOM	5492	CD	GLN	H	302	−4.603	22.977	6.191	1.00	7.54	B	C
  ATOM	5493	OE1	GLN	H	302	−3.715	23.822	6.297	1.00	7.28	B	O
  ATOM	5494	NE2	GLN	H	302	−5.364	22.870	5.108	1.00	9.27	B	N
  ATOM	5495	C	GLN	H	302	−4.885	19.978	9.434	1.00	2.42	B	C
  ATOM	5496	O	GLN	H	302	−4.564	19.038	8.706	1.00	2.40	B	O
  ATOM	5497	N	LEU	H	303	−5.964	19.959	10.207	1.00	2.00	B	N
  ATOM	5498	CA	LEU	H	303	−6.802	18.775	10.329	1.00	2.00	B	C
  ATOM	5499	CB	LEU	H	303	−6.945	18.389	11.802	1.00	2.00	B	C
  ATOM	5500	CG	LEU	H	303	−5.634	18.464	12.590	1.00	2.00	B	C
  ATOM	5501	CD1	LEU	H	303	−5.840	18.189	14.073	1.00	2.00	B	C
  ATOM	5502	CD2	LEU	H	303	−4.598	17.517	11.999	1.00	2.00	B	C
  ATOM	5503	C	LEU	H	303	−8.172	19.024	9.704	1.00	2.00	B	C
  ATOM	5504	O	LEU	H	303	−8.499	20.159	9.359	1.00	2.45	B	O
  ATOM	5505	N	PRO	H	304	−8.955	17.949	9.506	1.00	2.00	B	N
  ATOM	5506	CA	PRO	H	304	−10.222	18.040	8.763	1.00	2.07	B	C
  ATOM	5507	CB	PRO	H	304	−10.407	16.623	8.206	1.00	2.00	B	C
  ATOM	5508	CG	PRO	H	304	−9.560	15.748	9.074	1.00	2.00	B	C
  ATOM	5509	CD	PRO	H	304	−8.390	16.589	9.469	1.00	2.06	B	C
  ATOM	5510	C	PRO	H	304	−11.449	18.462	9.590	1.00	2.11	B	C
  ATOM	5511	O	PRO	H	304	−11.353	18.606	10.812	1.00	2.13	B	O
  ATOM	5512	N	ALA	H	305	−12.622	18.425	8.953	1.00	30.00	B	N
  ATOM	5513	CA	ALA	H	305	−12.858	19.173	7.708	1.00	30.00	B	C
  ATOM	5514	CB	ALA	H	305	−11.532	19.487	7.023	1.00	30.00	B	C
  ATOM	5515	C	ALA	H	305	−13.809	18.445	6.733	1.00	30.00	B	C
  ATOM	5516	O	ALA	H	305	−13.601	17.265	6.429	1.00	30.00	B	O
  ATOM	5517	N	TYR	H	306	−14.925	19.101	6.370	1.00	13.49	B	N
  ATOM	5518	CA	TYR	H	306	−15.658	18.816	5.101	1.00	13.70	B	C
  ATOM	5519	CB	TYR	H	306	−16.947	18.016	5.303	1.00	13.93	B	C
  ATOM	5520	CG	TYR	H	306	−17.614	18.033	6.640	1.00	14.08	B	C
  ATOM	5521	CD1	TYR	H	306	−18.719	18.859	6.857	1.00	14.59	B	C
  ATOM	5522	CE1	TYR	H	306	−19.825	18.384	7.554	1.00	14.82	B	C
  ATOM	5523	CZ	TYR	H	306	−19.818	17.083	8.031	1.00	14.52	B	C
  ATOM	5524	OH	TYR	H	306	−20.780	16.679	8.925	1.00	13.02	B	O
  ATOM	5525	CE2	TYR	H	306	−18.727	16.282	7.818	1.00	15.22	B	C
  ATOM	5526	CD2	TYR	H	306	−17.583	16.855	7.363	1.00	14.61	B	C
  ATOM	5527	C	TYR	H	306	−16.111	19.916	4.144	1.00	13.68	B	C
  ATOM	5528	O	TYR	H	306	−15.500	20.982	4.051	1.00	13.95	B	O
  ATOM	5529	N	GLY	H	307	−17.412	19.756	3.831	1.00	13.54	B	N
  ATOM	5530	CA	GLY	H	307	−18.190	20.428	2.747	1.00	13.37	B	C
  ATOM	5531	C	GLY	H	307	−18.295	19.776	1.353	1.00	13.47	B	C
  ATOM	5532	O	GLY	H	307	−17.282	19.701	0.658	1.00	13.90	B	O
  ATOM	5533	N	VAL	H	308	−19.505	19.569	0.815	1.00	13.31	B	N
  ATOM	5534	CA	VAL	H	308	−19.608	19.371	−0.649	1.00	13.30	B	C
  ATOM	5535	CB	VAL	H	308	−18.352	18.643	−1.188	1.00	13.03	B	C
  ATOM	5536	CG1	VAL	H	308	−17.948	19.190	−2.545	1.00	13.62	B	C
  ATOM	5537	CG2	VAL	H	308	−17.209	18.740	−0.205	1.00	12.86	B	C
  ATOM	5538	C	VAL	H	308	−20.720	18.501	−1.196	1.00	13.58	B	C
  ATOM	5539	O	VAL	H	308	−21.809	18.418	−0.627	1.00	13.71	B	O
  ATOM	5540	N	ILE	H	309	−20.173	17.489	−1.845	1.00	4.08	B	N
  ATOM	5541	CA	ILE	H	309	−19.600	16.440	−1.057	1.00	4.84	B	C
  ATOM	5542	CB	ILE	H	309	−19.530	16.902	0.426	1.00	4.89	B	C
  ATOM	5543	CG1	ILE	H	309	−18.554	18.070	0.585	1.00	5.85	B	C
  ATOM	5544	CD1	ILE	H	309	−17.312	17.711	1.373	1.00	8.12	B	C
  ATOM	5545	CG2	ILE	H	309	−19.121	15.756	1.332	1.00	4.44	B	C
  ATOM	5546	C	ILE	H	309	−20.750	15.497	−1.251	1.00	5.23	B	C
  ATOM	5547	O	ILE	H	309	−21.670	15.818	−1.998	1.00	5.92	B	O
  ATOM	5548	N	ASP	H	310	−20.752	14.358	−0.584	1.00	5.33	B	N
  ATOM	5549	CA	ASP	H	310	−21.992	13.604	−0.482	1.00	5.83	B	C
  ATOM	5550	CB	ASP	H	310	−23.072	14.462	0.188	1.00	6.21	B	C
  ATOM	5551	CG	ASP	H	310	−22.698	14.894	1.595	1.00	7.19	B	C
  ATOM	5552	OD1	ASP	H	310	−22.903	16.084	1.920	1.00	7.74	B	O
  ATOM	5553	OD2	ASP	H	310	−22.425	14.005	2.428	1.00	7.58	B	O
  ATOM	5554	C	ASP	H	310	−22.524	13.115	−1.841	1.00	6.02	B	C
  ATOM	5555	O	ASP	H	310	−23.670	12.673	−1.927	1.00	6.05	B	O
  ATOM	5556	N	THR	H	311	−21.716	13.207	−2.897	1.00	6.24	B	N
  ATOM	5557	CA	THR	H	311	−22.015	12.488	−4.140	1.00	6.14	B	C
  ATOM	5558	CB	THR	H	311	−21.097	12.933	−5.305	1.00	5.69	B	C
  ATOM	5559	OG1	THR	H	311	−20.497	14.196	−4.994	1.00	5.34	B	O
  ATOM	5560	CG2	THR	H	311	−21.891	13.063	−6.599	1.00	7.10	B	C
  ATOM	5561	C	THR	H	311	−21.832	10.990	−3.911	1.00	6.78	B	C
  ATOM	5562	O	THR	H	311	−20.946	10.587	−3.160	1.00	7.33	B	O
  ATOM	5563	N	PRO	H	312	−22.611	10.155	−4.621	1.00	7.00	B	N
  ATOM	5564	CA	PRO	H	312	−22.351	8.718	−4.567	1.00	7.23	B	C
  ATOM	5565	CB	PRO	H	312	−23.560	8.115	−5.289	1.00	7.00	B	C
  ATOM	5566	CG	PRO	H	312	−24.053	9.200	−6.178	1.00	6.59	B	C
  ATOM	5567	CD	PRO	H	312	−23.800	10.475	−5.432	1.00	6.99	B	C
  ATOM	5568	C	PRO	H	312	−21.061	8.352	−5.298	1.00	7.69	B	C
  ATOM	5569	O	PRO	H	312	−20.796	8.881	−6.377	1.00	7.55	B	O
  ATOM	5570	N	CYS	H	313	−20.259	7.469	−4.712	1.00	8.10	B	N
  ATOM	5571	CA	CYS	H	313	−19.271	6.730	−5.491	1.00	8.54	B	C
  ATOM	5572	CB	CYS	H	313	−17.840	7.078	−5.071	1.00	8.77	B	C
  ATOM	5573	SG	CYS	H	313	−17.635	8.680	−4.269	1.00	10.74	B	S
  ATOM	5574	C	CYS	H	313	−19.470	5.222	−5.446	1.00	8.19	B	C
  ATOM	5575	O	CYS	H	313	−20.334	4.712	−4.734	1.00	8.07	B	O
  ATOM	5576	N	TRP	H	314	−18.571	4.517	−6.121	1.00	7.93	B	N
  ATOM	5577	CA	TRP	H	314	−18.564	3.067	−6.116	1.00	7.80	B	C
  ATOM	5578	CB	TRP	H	314	−19.648	2.528	−7.050	1.00	8.13	B	C
  ATOM	5579	CG	TRP	H	314	−19.582	3.091	−8.436	1.00	9.09	B	C
  ATOM	5580	CD1	TRP	H	314	−19.041	2.490	−9.536	1.00	10.26	B	C
  ATOM	5581	NE1	TRP	H	314	−19.247	3.268	−10.650	1.00	10.86	B	N
  ATOM	5582	CE2	TRP	H	314	−19.940	4.392	−10.285	1.00	10.68	B	C
  ATOM	5583	CD2	TRP	H	314	−20.172	4.313	−8.897	1.00	10.49	B	C
  ATOM	5584	CE3	TRP	H	314	−20.877	5.347	−8.271	1.00	11.67	B	C
  ATOM	5585	CZ3	TRP	H	314	−21.301	6.419	−9.037	1.00	12.98	B	C
  ATOM	5586	CH2	TRP	H	314	−21.048	6.472	−10.413	1.00	12.74	B	C
  ATOM	5587	CZ2	TRP	H	314	−20.369	5.472	−11.054	1.00	11.73	B	C
  ATOM	5588	C	TRP	H	314	−17.198	2.576	−6.563	1.00	7.34	B	C
  ATOM	5589	O	TRP	H	314	−16.485	3.272	−7.288	1.00	7.47	B	O
  ATOM	5590	N	LYS	H	315	−16.791	1.426	−6.041	1.00	6.75	B	N
  ATOM	5591	CA	LYS	H	315	−15.547	0.807	−6.462	1.00	6.37	B	C
  ATOM	5592	CB	LYS	H	315	−14.741	0.337	−5.252	1.00	6.38	B	C
  ATOM	5593	CG	LYS	H	315	−13.277	0.071	−5.554	1.00	6.55	B	C
  ATOM	5594	CD	LYS	H	315	−12.509	−0.282	−4.292	1.00	8.01	B	C
  ATOM	5595	CE	LYS	H	315	−11.014	−0.331	−4.556	1.00	8.78	B	C
  ATOM	5596	NZ	LYS	H	315	−10.337	−1.364	−3.726	1.00	10.21	B	N
  ATOM	5597	C	LYS	H	315	−15.825	−0.361	−7.392	1.00	6.32	B	C
  ATOM	5598	O	LYS	H	315	−16.746	−1.145	−7.164	1.00	6.21	B	O
  ATOM	5599	N	LEU	H	316	−15.089	−0.411	−8.495	1.00	6.58	B	N
  ATOM	5600	CA	LEU	H	316	−15.304	−1.435	−9.502	1.00	7.02	B	C
  ATOM	5601	CB	LEU	H	316	−15.491	−0.801	−10.880	1.00	6.64	B	C
  ATOM	5602	CG	LEU	H	316	−15.452	−1.767	−12.065	1.00	6.21	B	C
  ATOM	5603	CD1	LEU	H	316	−16.540	−2.822	−11.936	1.00	5.94	B	C
  ATOM	5604	CD2	LEU	H	316	−15.590	−1.011	−13.378	1.00	6.57	B	C
  ATOM	5605	C	LEU	H	316	−14.138	−2.409	−9.525	1.00	7.77	B	C
  ATOM	5606	O	LEU	H	316	−12.999	−2.024	−9.792	1.00	8.47	B	O
  ATOM	5607	N	HIS	H	317	−14.414	−3.656	−9.168	1.00	8.05	B	N
  ATOM	5608	CA	HIS	H	317	−13.460	−4.725	−9.388	1.00	8.21	B	C
  ATOM	5609	CB	HIS	H	317	−13.266	−5.547	−8.116	1.00	9.04	B	C
  ATOM	5610	CG	HIS	H	317	−13.449	−4.761	−6.856	1.00	11.41	B	C
  ATOM	5611	ND1	HIS	H	317	−12.392	−4.368	−6.063	1.00	13.62	B	N
  ATOM	5612	CE1	HIS	H	317	−12.854	−3.746	−4.993	1.00	14.91	B	C
  ATOM	5613	NE2	HIS	H	317	−14.172	−3.725	−5.060	1.00	14.25	B	N
  ATOM	5614	CD2	HIS	H	317	−14.570	−4.352	−6.216	1.00	12.67	B	C
  ATOM	5615	C	HIS	H	317	−13.904	−5.625	−10.528	1.00	7.39	B	C
  ATOM	5616	O	HIS	H	317	−15.085	−5.677	−10.870	1.00	7.23	B	O
  ATOM	5617	N	THR	H	318	−12.976	−6.451	−10.993	1.00	7.11	B	N
  ATOM	5618	CA	THR	H	318	−12.973	−6.913	−12.372	1.00	6.56	B	C
  ATOM	5619	CB	THR	H	318	−12.242	−5.919	−13.295	1.00	6.28	B	C
  ATOM	5620	OG1	THR	H	318	−13.197	−5.193	−14.078	1.00	6.33	B	O
  ATOM	5621	CG2	THR	H	318	−11.296	−6.662	−14.224	1.00	6.52	B	C
  ATOM	5622	C	THR	H	318	−12.254	−8.251	−12.438	1.00	6.58	B	C
  ATOM	5623	O	THR	H	318	−11.142	−8.393	−11.930	1.00	6.67	B	O
  ATOM	5624	N	SER	H	319	−12.919	−9.252	−13.001	1.00	6.81	B	N
  ATOM	5625	CA	SER	H	319	−12.328	−10.578	−13.115	1.00	7.31	B	C
  ATOM	5626	CB	SER	H	319	−12.902	−11.513	−12.047	1.00	7.14	B	C
  ATOM	5627	OG	SER	H	319	−12.244	−12.769	−12.052	1.00	6.84	B	O
  ATOM	5628	C	SER	H	319	−12.533	−11.169	−14.509	1.00	7.93	B	C
  ATOM	5629	O	SER	H	319	−13.583	−10.975	−15.124	1.00	8.65	B	O
  ATOM	5630	N	PRO	H	320	−11.534	−11.917	−15.002	1.00	8.08	B	N
  ATOM	5631	CA	PRO	H	320	−11.592	−12.459	−16.354	1.00	8.34	B	C
  ATOM	5632	CB	PRO	H	320	−10.339	−13.342	−16.442	1.00	7.99	B	C
  ATOM	5633	CG	PRO	H	320	−9.773	−13.404	−15.045	1.00	8.01	B	C
  ATOM	5634	CD	PRO	H	320	−10.230	−12.163	−14.367	1.00	8.10	B	C
  ATOM	5635	C	PRO	H	320	−12.848	−13.288	−16.610	1.00	9.03	B	C
  ATOM	5636	O	PRO	H	320	−13.372	−13.928	−15.697	1.00	8.74	B	O
  ATOM	5637	N	LEU	H	321	−13.224	−13.384	−17.881	1.00	10.31	B	N
  ATOM	5638	CA	LEU	H	321	−14.514	−13.933	−18.284	1.00	11.63	B	C
  ATOM	5639	CB	LEU	H	321	−15.543	−12.807	−18.448	1.00	11.31	B	C
  ATOM	5640	CG	LEU	H	321	−17.032	−13.163	−18.454	1.00	10.97	B	C
  ATOM	5641	CD1	LEU	H	321	−17.828	−12.071	−19.154	1.00	10.04	B	C
  ATOM	5642	CD2	LEU	H	321	−17.273	−14.514	−19.113	1.00	10.69	B	C
  ATOM	5643	C	LEU	H	321	−14.359	−14.687	−19.603	1.00	12.92	B	C
  ATOM	5644	O	LEU	H	321	−13.871	−14.135	−20.591	1.00	13.29	B	O
  ATOM	5645	N	CYS	H	322	−14.788	−15.947	−19.611	1.00	13.39	B	N
  ATOM	5646	CA	CYS	H	322	−14.579	−16.836	−20.751	1.00	14.16	B	C
  ATOM	5647	CB	CYS	H	322	−13.459	−17.833	−20.451	1.00	13.72	B	C
  ATOM	5648	SG	CYS	H	322	−11.996	−17.091	−19.704	1.00	13.42	B	S
  ATOM	5649	C	CYS	H	322	−15.859	−17.589	−21.115	1.00	15.46	B	C
  ATOM	5650	O	CYS	H	322	−16.561	−18.099	−20.241	1.00	15.94	B	O
  ATOM	5651	N	THR	H	323	−16.097	−17.735	−22.415	1.00	16.70	B	N
  ATOM	5652	CA	THR	H	323	−17.059	−18.703	−22.940	1.00	17.84	B	C
  ATOM	5653	CB	THR	H	323	−17.054	−18.690	−24.477	1.00	17.50	B	C
  ATOM	5654	OG1	THR	H	323	−15.767	−18.268	−24.947	1.00	15.70	B	O
  ATOM	5655	CG2	THR	H	323	−18.118	−17.740	−25.005	1.00	18.05	B	C
  ATOM	5656	C	THR	H	323	−16.755	−20.125	−22.469	1.00	19.54	B	C
  ATOM	5657	O	THR	H	323	−15.670	−20.389	−21.950	1.00	19.84	B	O
  ATOM	5658	N	THR	H	324	−17.625	−21.068	−22.825	1.00	21.17	B	N
  ATOM	5659	CA	THR	H	324	−17.251	−22.481	−22.774	1.00	22.89	B	C
  ATOM	5660	CB	THR	H	324	−17.589	−23.138	−21.426	1.00	22.69	B	C
  ATOM	5661	OG1	THR	H	324	−18.025	−22.141	−20.494	1.00	22.10	B	O
  ATOM	5662	CG2	THR	H	324	−16.365	−23.854	−20.871	1.00	22.03	B	C
  ATOM	5663	C	THR	H	324	−17.737	−23.375	−23.915	1.00	24.39	B	C
  ATOM	5664	O	THR	H	324	−17.251	−24.495	−24.070	1.00	24.53	B	O
  ATOM	5665	N	ASN	H	325	−18.633	−22.866	−24.755	1.00	25.72	B	N
  ATOM	5666	CA	ASN	H	325	−18.864	−23.475	−26.064	1.00	27.01	B	C
  ATOM	5667	CB	ASN	H	325	−19.924	−24.578	−25.977	1.00	27.37	B	C
  ATOM	5668	CG	ASN	H	325	−19.337	−25.925	−25.593	1.00	28.46	B	C
  ATOM	5669	OD1	ASN	H	325	−19.134	−26.792	−26.443	1.00	30.37	B	O
  ATOM	5670	ND2	ASN	H	325	−19.086	−26.114	−24.303	1.00	28.78	B	N
  ATOM	5671	C	ASN	H	325	−19.246	−22.460	−27.136	1.00	27.36	B	C
  ATOM	5672	O	ASN	H	325	−19.634	−21.334	−26.829	1.00	27.94	B	O
  ATOM	5673	N	SER	H	330	−15.365	−21.167	−24.863	1.00	35.76	B	N
  ATOM	5674	CA	SER	H	330	−14.200	−21.669	−25.580	1.00	35.01	B	C
  ATOM	5675	CB	SER	H	330	−14.630	−22.631	−26.690	1.00	35.47	B	C
  ATOM	5676	OG	SER	H	330	−15.521	−22.000	−27.595	1.00	33.31	B	O
  ATOM	5677	C	SER	H	330	−13.383	−20.522	−26.168	1.00	34.35	B	C
  ATOM	5678	O	SER	H	330	−13.938	−19.509	−26.593	1.00	34.33	B	O
  ATOM	5679	N	ASN	H	331	−12.062	−20.653	−26.123	1.00	32.48	B	N
  ATOM	5680	CA	ASN	H	331	−11.191	−19.933	−27.046	1.00	30.72	B	C
  ATOM	5681	CB	ASN	H	331	−11.577	−20.233	−28.504	1.00	31.31	B	C
  ATOM	5682	CG	ASN	H	331	−11.276	−21.670	−28.918	1.00	32.11	B	C
  ATOM	5683	OD1	ASN	H	331	−10.553	−22.391	−28.229	1.00	32.54	B	O
  ATOM	5684	ND2	ASN	H	331	−11.753	−22.055	−30.097	1.00	31.30	B	N
  ATOM	5685	C	ASN	H	331	−11.120	−18.411	−26.826	1.00	28.71	B	C
  ATOM	5686	O	ASN	H	331	−10.495	−17.710	−27.621	1.00	29.07	B	O
  ATOM	5687	N	ILE	H	332	−11.797	−17.887	−25.802	1.00	25.44	B	N
  ATOM	5688	CA	ILE	H	332	−11.904	−16.424	−25.638	1.00	21.83	B	C
  ATOM	5689	CB	ILE	H	332	−12.919	−15.806	−26.624	1.00	21.42	B	C
  ATOM	5690	CG1	ILE	H	332	−12.916	−14.280	−26.511	1.00	19.89	B	C
  ATOM	5691	CD1	ILE	H	332	−11.986	−13.596	−27.488	1.00	17.67	B	C
  ATOM	5692	CG2	ILE	H	332	−14.314	−16.360	−26.374	1.00	20.61	B	C
  ATOM	5693	C	ILE	H	332	−12.204	−15.918	−24.217	1.00	20.37	B	C
  ATOM	5694	O	ILE	H	332	−13.219	−16.290	−23.624	1.00	19.95	B	O
  ATOM	5695	N	CYS	H	333	−11.425	−14.935	−23.761	1.00	18.27	B	N
  ATOM	5696	CA	CYS	H	333	−11.681	−14.282	−22.474	1.00	16.47	B	C
  ATOM	5697	CB	CYS	H	333	−10.802	−14.873	−21.371	1.00	16.14	B	C
  ATOM	5698	SG	CYS	H	333	−10.807	−16.672	−21.295	1.00	17.09	B	S
  ATOM	5699	C	CYS	H	333	−11.542	−12.763	−22.482	1.00	15.73	B	C
  ATOM	5700	O	CYS	H	333	−10.707	−12.206	−23.197	1.00	15.43	B	O
  ATOM	5701	N	LEU	H	334	−12.154	−12.155	−21.470	1.00	15.06	B	N
  ATOM	5702	CA	LEU	H	334	−12.256	−10.708	−21.353	1.00	13.79	B	C
  ATOM	5703	CB	LEU	H	334	−13.702	−10.264	−21.588	1.00	13.39	B	C
  ATOM	5704	CG	LEU	H	334	−14.262	−10.341	−23.008	1.00	13.93	B	C
  ATOM	5705	CD1	LEU	H	334	−15.276	−9.230	−23.235	1.00	14.20	B	C
  ATOM	5706	CD2	LEU	H	334	−13.143	−10.266	−24.035	1.00	14.52	B	C
  ATOM	5707	C	LEU	H	334	−11.868	−10.345	−19.930	1.00	13.22	B	C
  ATOM	5708	O	LEU	H	334	−12.324	−10.980	−18.980	1.00	13.31	B	O
  ATOM	5709	N	THR	H	335	−11.141	−9.246	−19.776	1.00	12.58	B	N
  ATOM	5710	CA	THR	H	335	−11.033	−8.596	−18.478	1.00	12.17	B	C
  ATOM	5711	CB	THR	H	335	−9.677	−8.904	−17.798	1.00	12.02	B	C
  ATOM	5712	OG1	THR	H	335	−9.207	−10.191	−18.219	1.00	12.64	B	O
  ATOM	5713	CG2	THR	H	335	−9.817	−8.893	−16.280	1.00	11.47	B	C
  ATOM	5714	C	THR	H	335	−11.203	−7.092	−18.639	1.00	11.97	B	C
  ATOM	5715	O	THR	H	335	−10.637	−6.493	−19.553	1.00	11.93	B	O
  ATOM	5716	N	ARG	H	336	−12.130	−6.526	−17.874	1.00	11.60	B	N
  ATOM	5717	CA	ARG	H	336	−12.411	−5.098	−17.949	1.00	12.15	B	C
  ATOM	5718	CB	ARG	H	336	−13.716	−4.767	−17.215	1.00	12.16	B	C
  ATOM	5719	CG	ARG	H	336	−14.525	−3.643	−17.849	1.00	12.67	B	C
  ATOM	5720	CD	ARG	H	336	−15.993	−4.018	−17.970	1.00	12.52	B	C
  ATOM	5721	NE	ARG	H	336	−16.736	−3.718	−16.750	1.00	12.35	B	N
  ATOM	5722	CZ	ARG	H	336	−17.058	−2.490	−16.355	1.00	12.54	B	C
  ATOM	5723	NH1	ARG	H	336	−16.665	−1.439	−17.062	1.00	12.38	B	N
  ATOM	5724	NH2	ARG	H	336	−17.761	−2.312	−15.246	1.00	12.48	B	N
  ATOM	5725	C	ARG	H	336	−11.252	−4.295	−17.361	1.00	12.71	B	C
  ATOM	5726	O	ARG	H	336	−10.891	−4.475	−16.198	1.00	12.62	B	O
  ATOM	5727	N	THR	H	337	−10.615	−3.475	−18.192	1.00	13.70	B	N
  ATOM	5728	CA	THR	H	337	−9.431	−2.733	−17.766	1.00	14.91	B	C
  ATOM	5729	CB	THR	H	337	−8.736	−2.032	−18.949	1.00	15.27	B	C
  ATOM	5730	OG1	THR	H	337	−8.620	−2.946	−20.046	1.00	16.65	B	O
  ATOM	5731	CG2	THR	H	337	−7.347	−1.560	−18.546	1.00	15.94	B	C
  ATOM	5732	C	THR	H	337	−9.759	−1.707	−16.681	1.00	15.16	B	C
  ATOM	5733	O	THR	H	337	−9.100	−1.659	−15.643	1.00	15.60	B	O
  ATOM	5734	N	ASP	H	338	−10.770	−0.880	−16.934	1.00	15.15	B	N
  ATOM	5735	CA	ASP	H	338	−10.988	0.325	−16.143	1.00	15.52	B	C
  ATOM	5736	CB	ASP	H	338	−11.999	1.250	−16.828	1.00	16.81	B	C
  ATOM	5737	CG	ASP	H	338	−13.028	0.489	−17.642	1.00	20.57	B	C
  ATOM	5738	OD1	ASP	H	338	−13.670	1.103	−18.519	1.00	23.00	B	O
  ATOM	5739	OD2	ASP	H	338	−13.224	−0.716	−17.378	1.00	22.92	B	O
  ATOM	5740	C	ASP	H	338	−11.453	−0.022	−14.733	1.00	14.21	B	C
  ATOM	5741	O	ASP	H	338	−12.651	−0.171	−14.482	1.00	14.00	B	O
  ATOM	5742	N	ARG	H	339	−10.494	−0.189	−13.827	1.00	12.79	B	N
  ATOM	5743	CA	ARG	H	339	−10.792	−0.528	−12.440	1.00	11.71	B	C
  ATOM	5744	CB	ARG	H	339	−9.866	−1.630	−11.950	1.00	11.73	B	C
  ATOM	5745	CG	ARG	H	339	−9.941	−2.905	−12.727	1.00	12.49	B	C
  ATOM	5746	CD	ARG	H	339	−9.329	−3.991	−11.895	1.00	13.24	B	C
  ATOM	5747	NE	ARG	H	339	−8.677	−5.006	−12.705	1.00	12.04	B	N
  ATOM	5748	CZ	ARG	H	339	−8.332	−6.200	−12.239	1.00	11.74	B	C
  ATOM	5749	NH1	ARG	H	339	−8.540	−6.498	−10.964	1.00	13.43	B	N
  ATOM	5750	NH2	ARG	H	339	−7.784	−7.097	−13.045	1.00	9.80	B	N
  ATOM	5751	C	ARG	H	339	−10.626	0.666	−11.519	1.00	11.16	B	C
  ATOM	5752	O	ARG	H	339	−9.690	1.448	−11.681	1.00	11.37	B	O
  ATOM	5753	N	GLY	H	340	−11.290	0.573	−10.373	1.00	10.43	B	N
  ATOM	5754	CA	GLY	H	340	−11.038	1.481	−9.269	1.00	9.52	B	C
  ATOM	5755	C	GLY	H	340	−12.279	2.268	−8.916	1.00	8.80	B	C
  ATOM	5756	O	GLY	H	340	−13.397	1.759	−8.996	1.00	8.56	B	O
  ATOM	5757	N	TRP	H	341	−12.077	3.513	−8.506	1.00	8.25	B	N
  ATOM	5758	CA	TRP	H	341	−13.156	4.309	−7.953	1.00	7.98	B	C
  ATOM	5759	CB	TRP	H	341	−12.629	5.235	−6.865	1.00	7.79	B	C
  ATOM	5760	CG	TRP	H	341	−12.435	4.538	−5.579	1.00	7.67	B	C
  ATOM	5761	CD1	TRP	H	341	−11.275	3.990	−5.119	1.00	8.12	B	C
  ATOM	5762	NE1	TRP	H	341	−11.496	3.346	−3.928	1.00	8.60	B	N
  ATOM	5763	CE2	TRP	H	341	−12.834	3.401	−3.639	1.00	7.57	B	C
  ATOM	5764	CD2	TRP	H	341	−13.464	4.093	−4.691	1.00	7.52	B	C
  ATOM	5765	CE3	TRP	H	341	−14.848	4.291	−4.636	1.00	7.86	B	C
  ATOM	5766	CZ3	TRP	H	341	−15.545	3.797	−3.548	1.00	7.14	B	C
  ATOM	5767	CH2	TRP	H	341	−14.890	3.105	−2.522	1.00	6.39	B	C
  ATOM	5768	CZ2	TRP	H	341	−13.538	2.903	−2.546	1.00	7.30	B	C
  ATOM	5769	C	TRP	H	341	−13.835	5.117	−9.037	1.00	8.26	B	C
  ATOM	5770	O	TRP	H	341	−13.222	5.978	−9.666	1.00	8.35	B	O
  ATOM	5771	N	TYR	H	342	−15.113	4.840	−9.244	1.00	8.44	B	N
  ATOM	5772	CA	TYR	H	342	−16.000	5.809	−9.847	1.00	8.53	B	C
  ATOM	5773	CB	TYR	H	342	−16.948	5.116	−10.814	1.00	8.43	B	C
  ATOM	5774	CG	TYR	H	342	−16.214	4.338	−11.870	1.00	9.17	B	C
  ATOM	5775	CD1	TYR	H	342	−15.551	3.163	−11.540	1.00	10.32	B	C
  ATOM	5776	CE1	TYR	H	342	−14.766	2.503	−12.465	1.00	10.99	B	C
  ATOM	5777	CZ	TYR	H	342	−14.566	3.063	−13.709	1.00	11.00	B	C
  ATOM	5778	OH	TYR	H	342	−13.828	2.387	−14.653	1.00	12.82	B	O
  ATOM	5779	CE2	TYR	H	342	−15.115	4.288	−14.019	1.00	10.67	B	C
  ATOM	5780	CD2	TYR	H	342	−15.913	4.930	−13.091	1.00	10.41	B	C
  ATOM	5781	C	TYR	H	342	−16.781	6.535	−8.778	1.00	8.64	B	C
  ATOM	5782	O	TYR	H	342	−16.830	6.103	−7.628	1.00	8.40	B	O
  ATOM	5783	N	CYS	H	343	−17.373	7.657	−9.157	1.00	8.87	B	N
  ATOM	5784	CA	CYS	H	343	−17.812	8.625	−8.178	1.00	9.35	B	C
  ATOM	5785	CB	CYS	H	343	−16.702	8.901	−7.160	1.00	9.17	B	C
  ATOM	5786	SG	CYS	H	343	−17.204	9.963	−5.787	1.00	11.88	B	S
  ATOM	5787	C	CYS	H	343	−18.258	9.907	−8.863	1.00	9.42	B	C
  ATOM	5788	O	CYS	H	343	−17.552	10.444	−9.717	1.00	9.96	B	O
  ATOM	5789	N	ASP	H	344	−19.523	10.250	−8.643	1.00	9.36	B	N
  ATOM	5790	CA	ASP	H	344	−20.231	11.213	−9.477	1.00	9.24	B	C
  ATOM	5791	CB	ASP	H	344	−21.712	11.250	−9.097	1.00	9.34	B	C
  ATOM	5792	CG	ASP	H	344	−22.555	10.320	−9.943	1.00	10.72	B	C
  ATOM	5793	OD1	ASP	H	344	−22.582	10.500	−11.178	1.00	13.93	B	O
  ATOM	5794	OD2	ASP	H	344	−23.246	9.453	−9.367	1.00	11.87	B	O
  ATOM	5795	C	ASP	H	344	−19.632	12.607	−9.330	1.00	9.09	B	C
  ATOM	5796	O	ASP	H	344	−19.454	13.101	−8.216	1.00	9.39	B	O
  ATOM	5797	N	ASN	H	345	−19.416	13.274	−10.457	1.00	9.13	B	N
  ATOM	5798	CA	ASN	H	345	−19.165	14.709	−10.461	1.00	9.52	B	C
  ATOM	5799	CB	ASN	H	345	−17.833	15.011	−11.149	1.00	9.61	B	C
  ATOM	5800	CG	ASN	H	345	−17.166	16.258	−10.606	1.00	9.21	B	C
  ATOM	5801	OD1	ASN	H	345	−16.787	16.316	−9.437	1.00	6.21	B	O
  ATOM	5802	ND2	ASN	H	345	−17.023	17.268	−11.456	1.00	11.05	B	N
  ATOM	5803	C	ASN	H	345	−20.303	15.452	−11.152	1.00	10.06	B	C
  ATOM	5804	O	ASN	H	345	−21.347	14.867	−11.441	1.00	11.10	B	O
  ATOM	5805	N	ALA	H	346	−20.133	16.755	−11.352	1.00	9.74	B	N
  ATOM	5806	CA	ALA	H	346	−21.211	17.584	−11.877	1.00	9.58	B	C
  ATOM	5807	CB	ALA	H	346	−20.708	18.991	−12.164	1.00	9.60	B	C
  ATOM	5808	C	ALA	H	346	−21.825	16.968	−13.133	1.00	9.66	B	C
  ATOM	5809	O	ALA	H	346	−21.347	17.196	−14.244	1.00	9.39	B	O
  ATOM	5810	N	GLY	H	347	−22.883	16.182	−12.948	1.00	10.04	B	N
  ATOM	5811	CA	GLY	H	347	−23.684	15.689	−14.067	1.00	10.68	B	C
  ATOM	5812	C	GLY	H	347	−22.964	14.606	−14.846	1.00	10.90	B	C
  ATOM	5813	O	GLY	H	347	−23.490	14.064	−15.819	1.00	11.46	B	O
  ATOM	5814	N	SER	H	348	−21.714	14.370	−14.467	1.00	10.30	B	N
  ATOM	5815	CA	SER	H	348	−20.844	13.436	−15.165	1.00	9.94	B	C
  ATOM	5816	CB	SER	H	348	−19.833	14.200	−16.022	1.00	9.88	B	C
  ATOM	5817	OG	SER	H	348	−20.488	15.064	−16.934	1.00	10.09	B	O
  ATOM	5818	C	SER	H	348	−20.120	12.619	−14.104	1.00	9.60	B	C
  ATOM	5819	O	SER	H	348	−20.367	12.796	−12.912	1.00	9.59	B	O
  ATOM	5820	N	VAL	H	349	−19.286	11.677	−14.528	1.00	9.54	B	N
  ATOM	5821	CA	VAL	H	349	−18.647	10.766	−13.581	1.00	9.56	B	C
  ATOM	5822	CB	VAL	H	349	−19.075	9.305	−13.809	1.00	9.28	B	C
  ATOM	5823	CG1	VAL	H	349	−18.659	8.442	−12.626	1.00	9.24	B	C
  ATOM	5824	CG2	VAL	H	349	−20.576	9.222	−14.033	1.00	9.94	B	C
  ATOM	5825	C	VAL	H	349	−17.126	10.861	−13.619	1.00	9.59	B	C
  ATOM	5826	O	VAL	H	349	−16.513	10.752	−14.681	1.00	9.69	B	O
  ATOM	5827	N	SER	H	350	−16.520	11.027	−12.449	1.00	9.93	B	N
  ATOM	5828	CA	SER	H	350	−15.073	11.104	−12.357	1.00	10.44	B	C
  ATOM	5829	CB	SER	H	350	−14.646	12.227	−11.408	1.00	10.04	B	C
  ATOM	5830	OG	SER	H	350	−14.584	13.468	−12.090	1.00	8.41	B	O
  ATOM	5831	C	SER	H	350	−14.459	9.773	−11.938	1.00	11.45	B	C
  ATOM	5832	O	SER	H	350	−15.000	9.062	−11.089	1.00	11.58	B	O
  ATOM	5833	N	PHE	H	351	−13.354	9.424	−12.587	1.00	12.28	B	N
  ATOM	5834	CA	PHE	H	351	−12.717	8.129	−12.403	1.00	13.04	B	C
  ATOM	5835	CB	PHE	H	351	−12.800	7.315	−13.697	1.00	12.87	B	C
  ATOM	5836	CG	PHE	H	351	−11.985	6.052	−13.677	1.00	13.52	B	C
  ATOM	5837	CD1	PHE	H	351	−12.081	5.165	−12.615	1.00	13.76	B	C
  ATOM	5838	CE1	PHE	H	351	−11.300	4.022	−12.574	1.00	14.10	B	C
  ATOM	5839	CZ	PHE	H	351	−10.453	3.726	−13.629	1.00	14.07	B	C
  ATOM	5840	CE2	PHE	H	351	−10.381	4.583	−14.715	1.00	14.14	B	C
  ATOM	5841	CD2	PHE	H	351	−11.134	5.744	−14.728	1.00	13.92	B	C
  ATOM	5842	C	PHE	H	351	−11.262	8.315	−11.993	1.00	13.84	B	C
  ATOM	5843	O	PHE	H	351	−10.528	9.090	−12.608	1.00	13.96	B	O
  ATOM	5844	N	PHE	H	352	−10.866	7.641	−10.919	1.00	14.72	B	N
  ATOM	5845	CA	PHE	H	352	−9.500	7.717	−10.418	1.00	15.98	B	C
  ATOM	5846	CB	PHE	H	352	−9.490	8.210	−8.966	1.00	15.75	B	C
  ATOM	5847	CG	PHE	H	352	−10.600	9.176	−8.638	1.00	15.51	B	C
  ATOM	5848	CD1	PHE	H	352	−11.835	8.713	−8.210	1.00	15.05	B	C
  ATOM	5849	CE1	PHE	H	352	−12.836	9.597	−7.837	1.00	14.05	B	C
  ATOM	5850	CZ	PHE	H	352	−12.592	10.955	−7.844	1.00	13.28	B	C
  ATOM	5851	CE2	PHE	H	352	−11.343	11.426	−8.201	1.00	13.71	B	C
  ATOM	5852	CD2	PHE	H	352	−10.347	10.536	−8.570	1.00	14.94	B	C
  ATOM	5853	C	PHE	H	352	−8.820	6.350	−10.511	1.00	17.56	B	C
  ATOM	5854	O	PHE	H	352	−9.259	5.390	−9.880	1.00	17.74	B	O
  ATOM	5855	N	PRO	H	353	−7.728	6.266	−11.288	1.00	19.05	B	N
  ATOM	5856	CA	PRO	H	353	−7.203	5.002	−11.802	1.00	20.40	B	C
  ATOM	5857	CB	PRO	H	353	−6.180	5.443	−12.859	1.00	20.26	B	C
  ATOM	5858	CG	PRO	H	353	−6.492	6.878	−13.145	1.00	19.71	B	C
  ATOM	5859	CD	PRO	H	353	−7.032	7.424	−11.869	1.00	18.97	B	C
  ATOM	5860	C	PRO	H	353	−6.522	4.135	−10.743	1.00	21.94	B	C
  ATOM	5861	O	PRO	H	353	−6.511	2.911	−10.873	1.00	22.29	B	O
  ATOM	5862	N	GLN	H	354	−5.904	4.757	−9.742	1.00	23.38	B	N
  ATOM	5863	CA	GLN	H	354	−5.118	4.007	−8.760	1.00	24.64	B	C
  ATOM	5864	CB	GLN	H	354	−3.621	4.108	−9.064	1.00	24.93	B	C
  ATOM	5865	CG	GLN	H	354	−3.259	5.210	−10.038	1.00	26.00	B	C
  ATOM	5866	CD	GLN	H	354	−3.331	6.581	−9.407	1.00	25.92	B	C
  ATOM	5867	OE1	GLN	H	354	−2.732	6.830	−8.360	1.00	25.67	B	O
  ATOM	5868	NE2	GLN	H	354	−4.094	7.475	−10.025	1.00	24.27	B	N
  ATOM	5869	C	GLN	H	354	−5.393	4.393	−7.307	1.00	24.85	B	C
  ATOM	5870	O	GLN	H	354	−5.653	5.558	−7.007	1.00	24.51	B	O
  ATOM	5871	N	ALA	H	355	−5.162	3.446	−6.399	1.00	25.22	B	N
  ATOM	5872	CA	ALA	H	355	−5.563	3.599	−4.997	1.00	25.34	B	C
  ATOM	5873	CB	ALA	H	355	−5.112	2.400	−4.173	1.00	25.09	B	C
  ATOM	5874	C	ALA	H	355	−5.092	4.910	−4.354	1.00	24.92	B	C
  ATOM	5875	O	ALA	H	355	−5.901	5.647	−3.790	1.00	25.23	B	O
  ATOM	5876	N	GLU	H	356	−3.775	5.074	−4.242	1.00	23.93	B	N
  ATOM	5877	CA	GLU	H	356	−3.138	6.394	−4.141	1.00	22.77	B	C
  ATOM	5878	CB	GLU	H	356	−2.214	6.635	−5.339	1.00	23.22	B	C
  ATOM	5879	CG	GLU	H	356	−0.973	5.756	−5.344	1.00	26.33	B	C
  ATOM	5880	CD	GLU	H	356	−0.571	5.312	−3.948	1.00	30.93	B	C
  ATOM	5881	OE1	GLU	H	356	−1.012	4.225	−3.516	1.00	31.97	B	O
  ATOM	5882	OE2	GLU	H	356	0.074	6.111	−3.237	1.00	32.21	B	O
  ATOM	5883	C	GLU	H	356	−4.114	7.558	−3.990	1.00	21.31	B	C
  ATOM	5884	O	GLU	H	356	−4.098	8.270	−2.985	1.00	21.01	B	O
  ATOM	5885	N	THR	H	357	−4.868	7.819	−5.052	1.00	19.51	B	N
  ATOM	5886	CA	THR	H	357	−5.718	9.000	−5.138	1.00	17.55	B	C
  ATOM	5887	CB	THR	H	357	−6.391	9.086	−6.519	1.00	17.30	B	C
  ATOM	5888	OG1	THR	H	357	−5.644	8.305	−7.462	1.00	17.32	B	O
  ATOM	5889	CG2	THR	H	357	−6.472	10.531	−6.997	1.00	17.72	B	C
  ATOM	5890	C	THR	H	357	−6.801	9.006	−4.063	1.00	16.62	B	C
  ATOM	5891	O	THR	H	357	−7.346	10.058	−3.730	1.00	17.29	B	O
  ATOM	5892	N	CYS	H	358	−7.179	7.822	−3.594	1.00	14.88	B	N
  ATOM	5893	CA	CYS	H	358	−8.414	7.676	−2.833	1.00	13.15	B	C
  ATOM	5894	CB	CYS	H	358	−9.479	6.949	−3.655	1.00	13.04	B	C
  ATOM	5895	SG	CYS	H	358	−10.003	7.836	−5.144	1.00	14.02	B	S
  ATOM	5896	C	CYS	H	358	−8.202	6.982	−1.492	1.00	12.08	B	C
  ATOM	5897	O	CYS	H	358	−7.521	5.959	−1.408	1.00	12.15	B	O
  ATOM	5898	N	LYS	H	359	−8.741	7.585	−0.438	1.00	11.35	B	N
  ATOM	5899	CA	LYS	H	359	−8.861	6.922	0.853	1.00	11.01	B	C
  ATOM	5900	CB	LYS	H	359	−8.119	7.713	1.931	1.00	11.16	B	C
  ATOM	5901	CG	LYS	H	359	−7.413	8.953	1.414	1.00	13.28	B	C
  ATOM	5902	CD	LYS	H	359	−5.907	8.816	1.540	1.00	16.11	B	C
  ATOM	5903	CE	LYS	H	359	−5.199	10.088	1.104	1.00	17.91	B	C
  ATOM	5904	NZ	LYS	H	359	−3.719	9.952	1.184	1.00	20.99	B	N
  ATOM	5905	C	LYS	H	359	−10.325	6.777	1.242	1.00	10.46	B	C
  ATOM	5906	O	LYS	H	359	−11.191	7.462	0.697	1.00	10.70	B	O
  ATOM	5907	N	VAL	H		360	−10.579	5.977	2.270	1.00	9.99	B	N
  ATOM	5908	CA	VAL	H	360	−11.939	5.576	2.592	1.00	9.84	B	C
  ATOM	5909	CB	VAL	H	360	−12.406	4.401	1.712	1.00	9.42	B	C
  ATOM	5910	CG1	VAL	H	360	−11.411	3.253	1.784	1.00	10.07	B	C
  ATOM	5911	CG2	VAL	H	360	−13.796	3.944	2.125	1.00	9.56	B	C
  ATOM	5912	C	VAL	H		360	−12.087	5.214	4.063	1.00	9.98	B	C
  ATOM	5913	O	VAL	H		360	−11.267	4.485	4.622	1.00	9.96	B	O
  ATOM	5914	N	GLN	H	361	−13.109	5.780	4.696	1.00	10.39	B	N
  ATOM	5915	CA	GLN	H	361	−13.322	5.606	6.125	1.00	11.53	B	C
  ATOM	5916	CB	GLN	H	361	−12.858	6.851	6.883	1.00	12.03	B	C
  ATOM	5917	CG	GLN	H	361	−13.051	6.769	8.385	1.00	16.44	B	C
  ATOM	5918	CD	GLN	H	361	−11.812	7.176	9.152	1.00	25.16	B	C
  ATOM	5919	OE1	GLN	H	361	−11.763	8.257	9.738	1.00	29.01	B	O
  ATOM	5920	NE2	GLN	H	361	−10.773	6.352	9.080	1.00	27.20	B	N
  ATOM	5921	C	GLN	H	361	−14.795	5.340	6.415	1.00	11.15	B	C
  ATOM	5922	O	GLN	H	361	−15.620	6.253	6.355	1.00	11.80	B	O
  ATOM	5923	N	SER	H	362	−15.136	4.078	6.650	1.00	10.90	B	N
  ATOM	5924	CA	SER	H	362	−16.529	3.677	6.634	1.00	10.30	B	C
  ATOM	5925	CB	SER	H	362	−17.326	4.548	7.603	1.00	10.47	B	C
  ATOM	5926	OG	SER	H	362	−18.616	4.011	7.823	1.00	11.17	B	O
  ATOM	5927	C	SER	H	362	−17.074	3.846	5.224	1.00	9.58	B	C
  ATOM	5928	O	SER	H	362	−16.419	3.474	4.250	1.00	9.48	B	O
  ATOM	5929	N	ASN	H	363	−18.182	4.569	5.115	1.00	9.12	B	N
  ATOM	5930	CA	ASN	H	363	−18.810	4.826	3.826	1.00	8.73	B	C
  ATOM	5931	CB	ASN	H	363	−20.329	4.778	3.972	1.00	9.01	B	C
  ATOM	5932	CG	ASN	H	363	−20.850	5.801	4.965	1.00	9.29	B	C
  ATOM	5933	OD1	ASN	H	363	−20.079	6.555	5.561	1.00	9.82	B	O
  ATOM	5934	ND2	ASN	H	363	−22.162	5.818	5.163	1.00	10.08	B	N
  ATOM	5935	C	ASN	H	363	−18.382	6.185	3.277	1.00	8.12	B	C
  ATOM	5936	O	ASN	H	363	−18.996	6.720	2.352	1.00	8.10	B	O
  ATOM	5937	N	ARG	H	364	−17.346	6.749	3.890	1.00	7.20	B	N
  ATOM	5938	CA	ARG	H	364	−16.777	8.017	3.457	1.00	6.82	B	C
  ATOM	5939	CB	ARG	H	364	−16.307	8.821	4.671	1.00	6.91	B	C
  ATOM	5940	CG	ARG	H	364	−16.741	10.271	4.655	1.00	7.92	B	C
  ATOM	5941	CD	ARG	H	364	−18.197	10.397	4.249	1.00	8.20	B	C
  ATOM	5942	NE	ARG	H	364	−18.377	11.314	3.127	1.00	8.70	B	N
  ATOM	5943	CZ	ARG	H	364	−19.450	12.077	2.958	1.00	8.88	B	C
  ATOM	5944	NH1	ARG	H	364	−20.420	12.062	3.862	1.00	8.57	B	N
  ATOM	5945	NH2	ARG	H	364	−19.546	12.867	1.897	1.00	10.59	B	N
  ATOM	5946	C	ARG	H	364	−15.603	7.775	2.519	1.00	6.58	B	C
  ATOM	5947	O	ARG	H	364	−14.680	7.030	2.847	1.00	6.65	B	O
  ATOM	5948	N	VAL	H	365	−15.619	8.448	1.375	1.00	6.64	B	N
  ATOM	5949	CA	VAL	H	365	−14.526	8.350	0.419	1.00	6.54	B	C
  ATOM	5950	CB	VAL	H	365	−15.000	7.763	−0.922	1.00	5.95	B	C
  ATOM	5951	CG1	VAL	H	365	−13.934	7.950	−1.990	1.00	5.48	B	C
  ATOM	5952	CG2	VAL	H	365	−15.350	6.292	−0.762	1.00	6.22	B	C
  ATOM	5953	C	VAL	H	365	−13.914	9.719	0.166	1.00	7.35	B	C
  ATOM	5954	O	VAL	H	365	−14.617	10.729	0.128	1.00	8.33	B	O
  ATOM	5955	N	PHE	H	366	−12.611	9.733	−0.081	1.00	7.37	B	N
  ATOM	5956	CA	PHE	H	366	−11.904	10.969	−0.360	1.00	7.44	B	C
  ATOM	5957	CB	PHE	H	366	−11.137	11.431	0.874	1.00	7.30	B	C
  ATOM	5958	CG	PHE	H	366	−12.009	11.714	2.054	1.00	6.70	B	C
  ATOM	5959	CD1	PHE	H	366	−12.571	10.677	2.778	1.00	6.70	B	C
  ATOM	5960	CE1	PHE	H	366	−13.347	10.932	3.894	1.00	5.94	B	C
  ATOM	5961	CZ	PHE	H	366	−13.546	12.236	4.311	1.00	5.71	B	C
  ATOM	5962	CE2	PHE	H	366	−12.990	13.279	3.593	1.00	5.96	B	C
  ATOM	5963	CD2	PHE	H	366	−12.235	13.015	2.467	1.00	6.52	B	C
  ATOM	5964	C	PHE	H	366	−10.939	10.777	−1.511	1.00	7.45	B	C
  ATOM	5965	O	PHE	H	366	−9.931	10.082	−1.381	1.00	7.45	B	O
  ATOM	5966	N	CYS	H	367	−11.212	11.453	−2.618	1.00	8.00	B	N
  ATOM	5967	CA	CYS	H	367	−10.408	11.281	−3.809	1.00	8.90	B	C
  ATOM	5968	CB	CYS	H	367	−11.217	10.596	−4.909	1.00	9.46	B	C
  ATOM	5969	SG	CYS	H	367	−11.640	8.877	−4.545	1.00	10.79	B	S
  ATOM	5970	C	CYS	H	367	−9.870	12.612	−4.297	1.00	9.09	B	C
  ATOM	5971	O	CYS	H	367	−10.363	13.674	−3.919	1.00	9.24	B	O
  ATOM	5972	N	ASP	H	368	−8.892	12.540	−5.188	1.00	9.54	B	N
  ATOM	5973	CA	ASP	H	368	−8.190	13.724	−5.637	1.00	10.55	B	C
  ATOM	5974	CB	ASP	H	368	−6.693	13.584	−5.372	1.00	10.53	B	C
  ATOM	5975	CG	ASP	H	368	−5.983	14.917	−5.352	1.00	11.11	B	C
  ATOM	5976	OD1	ASP	H	368	−6.335	15.787	−6.177	1.00	11.42	B	O
  ATOM	5977	OD2	ASP	H	368	−5.158	15.138	−4.441	1.00	11.35	B	O
  ATOM	5978	C	ASP	H	368	−8.442	13.949	−7.118	1.00	11.45	B	C
  ATOM	5979	O	ASP	H	368	−8.036	13.143	−7.955	1.00	12.05	B	O
  ATOM	5980	N	THR	H	369	−9.222	14.980	−7.425	1.00	12.41	B	N
  ATOM	5981	CA	THR	H	369	−9.359	15.444	−8.796	1.00	13.00	B	C
  ATOM	5982	CB	THR	H	369	−9.723	16.934	−8.846	1.00	12.69	B	C
  ATOM	5983	OG1	THR	H	369	−10.937	17.158	−8.117	1.00	11.72	B	O
  ATOM	5984	CG2	THR	H	369	−9.896	17.390	−10.289	1.00	13.33	B	C
  ATOM	5985	C	THR	H	369	−8.052	15.254	−9.548	1.00	14.13	B	C
  ATOM	5986	O	THR	H	369	−7.986	14.504	−10.520	1.00	14.72	B	O
  ATOM	5987	N	MET	H	370	−6.996	15.868	−9.029	1.00	15.25	B	N
  ATOM	5988	CA	MET	H	370	−5.822	16.195	−9.825	1.00	16.60	B	C
  ATOM	5989	CB	MET	H	370	−4.542	15.983	−9.019	1.00	17.42	B	C
  ATOM	5990	CG	MET	H	370	−3.815	17.270	−8.673	1.00	20.31	B	C
  ATOM	5991	SD	MET	H	370	−3.256	18.144	−10.144	1.00	26.43	B	S
  ATOM	5992	CE	MET	H	370	−4.817	18.449	−10.970	1.00	24.07	B	C
  ATOM	5993	C	MET	H	370	−5.752	15.466	−11.165	1.00	16.54	B	C
  ATOM	5994	O	MET	H	370	−5.659	16.108	−12.209	1.00	16.74	B	O
  ATOM	5995	N	ASN	H	371	−5.730	14.137	−11.146	1.00	16.35	B	N
  ATOM	5996	CA	ASN	H	371	−5.564	13.390	−12.394	1.00	16.07	B	C
  ATOM	5997	CB	ASN	H	371	−4.271	12.573	−12.386	1.00	16.41	B	C
  ATOM	5998	CG	ASN	H	371	−3.047	13.428	−12.644	1.00	16.71	B	C
  ATOM	5999	OD1	ASN	H	371	−2.747	13.766	−13.790	1.00	15.75	B	O
  ATOM	6000	ND2	ASN	H	371	−2.401	13.874	−11.572	1.00	17.76	B	N
  ATOM	6001	C	ASN	H	371	−6.767	12.552	−12.827	1.00	15.55	B	C
  ATOM	6002	O	ASN	H	371	−6.757	11.959	−13.907	1.00	15.84	B	O
  ATOM	6003	N	SER	H	372	−7.879	12.750	−12.126	1.00	14.76	B	N
  ATOM	6004	CA	SER	H	372	−9.165	12.189	−12.526	1.00	13.91	B	C
  ATOM	6005	CB	SER	H	372	−10.309	12.932	−11.832	1.00	14.04	B	C
  ATOM	6006	OG	SER	H	372	−10.226	14.328	−12.061	1.00	15.09	B	O
  ATOM	6007	C	SER	H	372	−9.372	12.202	−14.037	1.00	13.07	B	C
  ATOM	6008	O	SER	H	372	−8.839	13.056	−14.743	1.00	13.02	B	O
  ATOM	6009	N	LEU	H	373	−10.112	11.213	−14.526	1.00	12.23	B	N
  ATOM	6010	CA	LEU	H	373	−10.687	11.256	−15.864	1.00	11.45	B	C
  ATOM	6011	CB	LEU	H	373	−10.417	9.939	−16.594	1.00	11.43	B	C
  ATOM	6012	CG	LEU	H	373	−9.204	9.880	−17.524	1.00	11.04	B	C
  ATOM	6013	CD1	LEU	H	373	−7.988	10.551	−16.888	1.00	11.76	B	C
  ATOM	6014	CD2	LEU	H	373	−8.894	8.435	−17.915	1.00	10.49	B	C
  ATOM	6015	C	LEU	H	373	−12.188	11.472	−15.762	1.00	11.17	B	C
  ATOM	6016	O	LEU	H	373	−12.847	10.886	−14.904	1.00	11.27	B	O
  ATOM	6017	N	THR	H	374	−12.733	12.289	−16.655	1.00	10.70	B	N
  ATOM	6018	CA	THR	H	374	−14.144	12.637	−16.586	1.00	10.23	B	C
  ATOM	6019	CB	THR	H	374	−14.367	14.151	−16.730	1.00	10.24	B	C
  ATOM	6020	OG1	THR	H	374	−13.177	14.850	−16.344	1.00	11.25	B	O
  ATOM	6021	CG2	THR	H	374	−15.521	14.604	−15.849	1.00	10.52	B	C
  ATOM	6022	C	THR	H	374	−14.953	11.896	−17.641	1.00	9.54	B	C
  ATOM	6023	O	THR	H	374	−14.580	11.855	−18.813	1.00	9.70	B	O
  ATOM	6024	N	LEU	H	375	−16.035	11.266	−17.198	1.00	8.83	B	N
  ATOM	6025	CA	LEU	H	375	−16.731	10.270	−18.000	1.00	7.83	B	C
  ATOM	6026	CB	LEU	H	375	−16.360	8.861	−17.540	1.00	7.38	B	C
  ATOM	6027	CG	LEU	H	375	−14.878	8.495	−17.551	1.00	5.06	B	C
  ATOM	6028	CD1	LEU	H	375	−14.710	7.045	−17.124	1.00	2.41	B	C
  ATOM	6029	CD2	LEU	H	375	−14.288	8.729	−18.934	1.00	4.31	B	C
  ATOM	6030	C	LEU	H	375	−18.236	10.456	−17.878	1.00	7.79	B	C
  ATOM	6031	O	LEU	H	375	−18.724	10.928	−16.850	1.00	7.92	B	O
  ATOM	6032	N	PRO	H	376	−18.982	9.954	−18.871	1.00	7.51	B	N
  ATOM	6033	CA	PRO	H	376	−20.439	10.009	−18.882	1.00	7.90	B	C
  ATOM	6034	CB	PRO	H	376	−20.780	9.837	−20.362	1.00	7.90	B	C
  ATOM	6035	CG	PRO	H	376	−19.657	9.033	−20.908	1.00	7.97	B	C
  ATOM	6036	CD	PRO	H	376	−18.435	9.468	−20.150	1.00	7.40	B	C
  ATOM	6037	C	PRO	H	376	−21.063	8.881	−18.064	1.00	8.35	B	C
  ATOM	6038	O	PRO	H	376	−20.569	7.753	−18.085	1.00	8.71	B	O
  ATOM	6039	N	SER	H	377	−22.190	9.172	−17.421	1.00	9.11	B	N
  ATOM	6040	CA	SER	H	377	−22.937	8.165	−16.673	1.00	9.91	B	C
  ATOM	6041	CB	SER	H	377	−24.272	8.737	−16.191	1.00	10.23	B	C
  ATOM	6042	OG	SER	H	377	−24.293	10.150	−16.304	1.00	10.90	B	O
  ATOM	6043	C	SER	H	377	−23.180	6.915	−17.513	1.00	10.14	B	C
  ATOM	6044	O	SER	H	377	−23.678	5.906	−17.013	1.00	10.08	B	O
  ATOM	6045	N	GLU	H	378	−22.875	7.010	−18.803	1.00	10.71	B	N
  ATOM	6046	CA	GLU	H	378	−23.057	5.893	−19.721	1.00	11.40	B	C
  ATOM	6047	CB	GLU	H	378	−22.970	6.377	−21.170	1.00	11.65	B	C
  ATOM	6048	CG	GLU	H	378	−24.261	6.977	−21.706	1.00	13.46	B	C
  ATOM	6049	CD	GLU	H	378	−24.671	8.241	−20.972	1.00	16.20	B	C
  ATOM	6050	OE1	GLU	H	378	−23.922	8.681	−20.074	1.00	15.73	B	O
  ATOM	6051	OE2	GLU	H	378	−25.749	8.788	−21.285	1.00	18.38	B	O
  ATOM	6052	C	GLU	H	378	−22.019	4.805	−19.468	1.00	11.27	B	C
  ATOM	6053	O	GLU	H	378	−22.196	3.657	−19.877	1.00	11.28	B	O
  ATOM	6054	N	VAL	H	379	−20.943	5.170	−18.779	1.00	11.31	B	N
  ATOM	6055	CA	VAL	H	379	−19.977	4.192	−18.296	1.00	11.59	B	C
  ATOM	6056	CB	VAL	H	379	−18.973	4.824	−17.315	1.00	11.27	B	C
  ATOM	6057	CG1	VAL	H	379	−18.343	3.752	−16.440	1.00	11.60	B	C
  ATOM	6058	CG2	VAL	H	379	−17.905	5.597	−18.073	1.00	11.54	B	C
  ATOM	6059	C	VAL	H	379	−20.675	3.023	−17.610	1.00	12.16	B	C
  ATOM	6060	O	VAL	H	379	−20.260	1.872	−17.750	1.00	12.51	B	O
  ATOM	6061	N	ASN	H	380	−21.769	3.317	−16.915	1.00	12.98	B	N
  ATOM	6062	CA	ASN	H	380	−22.428	2.328	−16.068	1.00	14.00	B	C
  ATOM	6063	CB	ASN	H	380	−23.553	2.973	−15.258	1.00	14.59	B	C
  ATOM	6064	CG	ASN	H	380	−23.038	3.964	−14.234	1.00	17.09	B	C
  ATOM	6065	OD1	ASN	H	380	−22.893	3.637	−13.056	1.00	20.41	B	O
  ATOM	6066	ND2	ASN	H	380	−22.690	5.160	−14.693	1.00	18.86	B	N
  ATOM	6067	C	ASN	H	380	−22.954	1.115	−16.833	1.00	13.96	B	C
  ATOM	6068	O	ASN	H	380	−22.973	0.005	−16.302	1.00	14.38	B	O
  ATOM	6069	N	LEU	H	381	−23.459	1.343	−18.042	1.00	13.61	B	N
  ATOM	6070	CA	LEU	H	381	−24.024	0.261	−18.844	1.00	13.72	B	C
  ATOM	6071	CB	LEU	H	381	−24.514	0.792	−20.191	1.00	13.79	B	C
  ATOM	6072	CG	LEU	H	381	−25.004	2.240	−20.194	1.00	14.92	B	C
  ATOM	6073	CD1	LEU	H	381	−25.409	2.670	−21.595	1.00	15.56	B	C
  ATOM	6074	CD2	LEU	H	381	−26.157	2.422	−19.218	1.00	15.78	B	C
  ATOM	6075	C	LEU	H	381	−22.982	−0.827	−19.060	1.00	13.62	B	C
  ATOM	6076	O	LEU	H	381	−23.314	−1.973	−19.365	1.00	13.57	B	O
  ATOM	6077	N	CYS	H	382	−21.729	−0.478	−18.796	1.00	13.47	B	N
  ATOM	6078	CA	CYS	H	382	−20.615	−1.367	−19.068	1.00	13.57	B	C
  ATOM	6079	CB	CYS	H	382	−19.321	−0.565	−19.165	1.00	13.62	B	C
  ATOM	6080	SG	CYS	H	382	−18.814	−0.217	−20.852	1.00	15.64	B	S
  ATOM	6081	C	CYS	H	382	−20.494	−2.432	−17.987	1.00	13.33	B	C
  ATOM	6082	O	CYS	H	382	−19.948	−3.510	−18.224	1.00	13.57	B	O
  ATOM	6083	N	ASN	H	383	−21.096	−2.163	−16.833	1.00	13.21	B	N
  ATOM	6084	CA	ASN	H	383	−21.267	−3.181	−15.803	1.00	13.22	B	C
  ATOM	6085	CB	ASN	H	383	−21.854	−2.568	−14.531	1.00	13.18	B	C
  ATOM	6086	CG	ASN	H	383	−21.059	−1.381	−14.034	1.00	13.42	B	C
  ATOM	6087	OD1	ASN	H	383	−19.830	−1.418	−13.985	1.00	13.68	B	O
  ATOM	6088	ND2	ASN	H	383	−21.761	−0.330	−13.626	1.00	14.32	B	N
  ATOM	6089	C	ASN	H	383	−22.159	−4.317	−16.277	1.00	13.28	B	C
  ATOM	6090	O	ASN	H	383	−22.096	−5.428	−15.751	1.00	13.50	B	O
  ATOM	6091	N	VAL	H	384	−23.092	−3.990	−17.164	1.00	13.24	B	N
  ATOM	6092	CA	VAL	H	384	−24.065	−4.964	−17.630	1.00	13.29	B	C
  ATOM	6093	CB	VAL	H	384	−25.484	−4.367	−17.709	1.00	13.28	B	C
  ATOM	6094	CG1	VAL	H	384	−26.371	−5.222	−18.601	1.00	13.73	B	C
  ATOM	6095	CG2	VAL	H	384	−26.083	−4.241	−16.315	1.00	12.76	B	C
  ATOM	6096	C	VAL	H	384	−23.677	−5.563	−18.977	1.00	13.57	B	C
  ATOM	6097	O	VAL	H	384	−23.940	−6.737	−19.233	1.00	13.31	B	O
  ATOM	6098	N	ASP	H	385	−23.060	−4.764	−19.843	1.00	14.07	B	N
  ATOM	6099	CA	ASP	H	385	−22.923	−5.172	−21.238	1.00	14.61	B	C
  ATOM	6100	CB	ASP	H	385	−23.915	−4.459	−22.154	1.00	14.71	B	C
  ATOM	6101	CG	ASP	H	385	−24.584	−5.410	−23.130	1.00	16.69	B	C
  ATOM	6102	OD1	ASP	H	385	−24.093	−6.549	−23.281	1.00	18.63	B	O
  ATOM	6103	OD2	ASP	H	385	−25.614	−5.030	−23.724	1.00	19.10	B	O
  ATOM	6104	C	ASP	H	385	−21.525	−5.244	−21.851	1.00	14.63	B	C
  ATOM	6105	O	ASP	H	385	−21.203	−6.221	−22.526	1.00	14.34	B	O
  ATOM	6106	N	ILE	H	386	−20.722	−4.198	−21.691	1.00	14.54	B	N
  ATOM	6107	CA	ILE	H	386	−19.435	−4.146	−22.382	1.00	14.46	B	C
  ATOM	6108	CB	ILE	H	386	−18.772	−5.540	−22.417	1.00	13.83	B	C
  ATOM	6109	CG1	ILE	H	386	−18.450	−6.032	−21.009	1.00	13.44	B	C
  ATOM	6110	CD1	ILE	H	386	−18.701	−7.516	−20.821	1.00	12.39	B	C
  ATOM	6111	CG2	ILE	H	386	−17.533	−5.525	−23.298	1.00	13.51	B	C
  ATOM	6112	C	ILE	H	386	−19.673	−3.755	−23.830	1.00	14.73	B	C
  ATOM	6113	O	ILE	H	386	−19.266	−2.682	−24.274	1.00	14.68	B	O
  ATOM	6114	N	PHE	H	387	−20.135	−4.733	−24.601	1.00	14.71	B	N
  ATOM	6115	CA	PHE	H	387	−20.696	−4.482	−25.915	1.00	14.78	B	C
  ATOM	6116	CB	PHE	H	387	−20.739	−5.766	−26.733	1.00	14.77	B	C
  ATOM	6117	CG	PHE	H	387	−19.482	−6.569	−26.647	1.00	14.75	B	C
  ATOM	6118	CD1	PHE	H	387	−19.407	−7.658	−25.797	1.00	15.03	B	C
  ATOM	6119	CE1	PHE	H	387	−18.229	−8.368	−25.662	1.00	14.62	B	C
  ATOM	6120	CZ	PHE	H	387	−17.093	−7.943	−26.318	1.00	14.55	B	C
  ATOM	6121	CE2	PHE	H	387	−17.136	−6.809	−27.103	1.00	14.68	B	C
  ATOM	6122	CD2	PHE	H	387	−18.316	−6.103	−27.227	1.00	14.61	B	C
  ATOM	6123	C	PHE	H	387	−22.080	−3.871	−25.821	1.00	14.91	B	C
  ATOM	6124	O	PHE	H	387	−22.992	−4.445	−25.228	1.00	14.86	B	O
  ATOM	6125	N	ASN	H	388	−22.144	−2.610	−26.216	1.00	15.11	B	N
  ATOM	6126	CA	ASN	H	388	−23.383	−1.869	−26.295	1.00	15.38	B	C
  ATOM	6127	CB	ASN	H	388	−23.968	−1.663	−24.897	1.00	14.86	B	C
  ATOM	6128	CG	ASN	H	388	−23.005	−0.958	−23.963	1.00	14.86	B	C
  ATOM	6129	OD1	ASN	H	388	−22.936	0.270	−23.935	1.00	12.80	B	O
  ATOM	6130	ND2	ASN	H	388	−22.213	−1.736	−23.234	1.00	15.97	B	N
  ATOM	6131	C	ASN	H	388	−23.023	−0.526	−26.906	1.00	16.11	B	C
  ATOM	6132	O	ASN	H	388	−21.965	0.024	−26.599	1.00	15.92	B	O
  ATOM	6133	N	PRO	H	389	−23.772	−0.117	−27.935	1.00	16.99	B	N
  ATOM	6134	CA	PRO	H	389	−23.716	1.289	−28.309	1.00	17.40	B	C
  ATOM	6135	CB	PRO	H	389	−24.965	1.468	−29.176	1.00	17.72	B	C
  ATOM	6136	CG	PRO	H	389	−25.904	0.425	−28.694	1.00	17.47	B	C
  ATOM	6137	CD	PRO	H	389	−25.041	−0.747	−28.339	1.00	17.05	B	C
  ATOM	6138	C	PRO	H	389	−23.810	2.170	−27.071	1.00	17.86	B	C
  ATOM	6139	O	PRO	H	389	−24.276	1.718	−26.025	1.00	18.45	B	O
  ATOM	6140	N	LYS	H	390	−23.335	3.406	−27.180	1.00	17.97	B	N
  ATOM	6141	CA	LYS	H	390	−23.325	4.318	−26.045	1.00	18.06	B	C
  ATOM	6142	CB	LYS	H	390	−24.373	3.904	−25.009	1.00	17.92	B	C
  ATOM	6143	CG	LYS	H	390	−25.807	4.197	−25.424	1.00	18.58	B	C
  ATOM	6144	CD	LYS	H	390	−26.259	5.564	−24.935	1.00	20.61	B	C
  ATOM	6145	CE	LYS	H	390	−27.775	5.656	−24.875	1.00	21.48	B	C
  ATOM	6146	NZ	LYS	H	390	−28.387	5.669	−26.232	1.00	23.16	B	N
  ATOM	6147	C	LYS	H	390	−21.946	4.403	−25.400	1.00	18.01	B	C
  ATOM	6148	O	LYS	H	390	−21.382	5.490	−25.279	1.00	18.43	B	O
  ATOM	6149	N	TYR	H	391	−21.391	3.261	−25.011	1.00	17.68	B	N
  ATOM	6150	CA	TYR	H	391	−20.012	3.232	−24.539	1.00	17.33	B	C
  ATOM	6151	CB	TYR	H	391	−19.948	3.140	−23.015	1.00	17.42	B	C
  ATOM	6152	CG	TYR	H	391	−18.847	3.986	−22.423	1.00	17.27	B	C
  ATOM	6153	CD1	TYR	H	391	−18.602	5.263	−22.911	1.00	17.29	B	C
  ATOM	6154	CE1	TYR	H	391	−17.553	6.021	−22.434	1.00	17.32	B	C
  ATOM	6155	CZ	TYR	H	391	−16.698	5.486	−21.496	1.00	16.51	B	C
  ATOM	6156	OH	TYR	H	391	−15.654	6.241	−21.015	1.00	16.65	B	O
  ATOM	6157	CE2	TYR	H	391	−16.878	4.195	−21.045	1.00	16.52	B	C
  ATOM	6158	CD2	TYR	H	391	−17.933	3.444	−21.530	1.00	17.24	B	C
  ATOM	6159	C	TYR	H	391	−19.179	2.130	−25.176	1.00	17.43	B	C
  ATOM	6160	O	TYR	H	391	−19.459	0.946	−24.993	1.00	17.70	B	O
  ATOM	6161	N	ASP	H	392	−18.075	2.522	−25.804	1.00	17.56	B	N
  ATOM	6162	CA	ASP	H	392	−16.973	1.599	−26.012	1.00	17.69	B	C
  ATOM	6163	CB	ASP	H	392	−16.119	2.003	−27.214	1.00	17.89	B	C
  ATOM	6164	CG	ASP	H	392	−16.587	3.290	−27.853	1.00	18.86	B	C
  ATOM	6165	OD1	ASP	H	392	−16.582	4.332	−27.165	1.00	20.34	B	O
  ATOM	6166	OD2	ASP	H	392	−16.931	3.269	−29.053	1.00	18.51	B	O
  ATOM	6167	C	ASP	H	392	−16.115	1.473	−24.767	1.00	17.11	B	C
  ATOM	6168	O	ASP	H	392	−15.801	2.460	−24.101	1.00	17.04	B	O
  ATOM	6169	N	CYS	H	393	−15.736	0.239	−24.468	1.00	16.33	B	N
  ATOM	6170	CA	CYS	H	393	−15.683	−0.240	−23.102	1.00	16.17	B	C
  ATOM	6171	CB	CYS	H	393	−16.818	−1.230	−22.851	1.00	16.11	B	C
  ATOM	6172	SG	CYS	H	393	−17.226	−1.449	−21.117	1.00	20.23	B	S
  ATOM	6173	C	CYS	H	393	−14.355	−0.941	−22.926	1.00	15.37	B	C
  ATOM	6174	O	CYS	H	393	−14.044	−1.876	−23.663	1.00	15.15	B	O
  ATOM	6175	N	LYS	H	394	−13.482	−0.332	−22.138	1.00	14.91	B	N
  ATOM	6176	CA	LYS	H	394	−12.100	−0.755	−22.107	1.00	14.50	B	C
  ATOM	6177	CB	LYS	H	394	−11.242	0.294	−21.405	1.00	14.60	B	C
  ATOM	6178	CG	LYS	H	394	−11.613	1.723	−21.788	1.00	16.44	B	C
  ATOM	6179	CD	LYS	H	394	−10.460	2.688	−21.576	1.00	20.45	B	C
  ATOM	6180	CE	LYS	H	394	−10.252	2.974	−20.099	1.00	23.05	B	C
  ATOM	6181	NZ	LYS	H	394	−9.330	1.988	−19.467	1.00	24.13	B	N
  ATOM	6182	C	LYS	H	394	−11.955	−2.130	−21.463	1.00	14.00	B	C
  ATOM	6183	O	LYS	H	394	−12.593	−2.434	−20.454	1.00	14.14	B	O
  ATOM	6184	N	ILE	H	395	−11.118	−2.957	−22.077	1.00	13.28	B	N
  ATOM	6185	CA	ILE	H	395	−11.238	−4.407	−22.026	1.00	12.89	B	C
  ATOM	6186	CB	ILE	H	395	−12.208	−4.925	−23.106	1.00	12.75	B	C
  ATOM	6187	CG1	ILE	H	395	−13.660	−4.699	−22.690	1.00	13.58	B	C
  ATOM	6188	CD1	ILE	H	395	−14.633	−4.719	−23.849	1.00	15.33	B	C
  ATOM	6189	CG2	ILE	H	395	−11.947	−6.396	−23.399	1.00	12.16	B	C
  ATOM	6190	C	ILE	H	395	−9.860	−4.906	−22.407	1.00	13.15	B	C
  ATOM	6191	O	ILE	H	395	−9.242	−4.353	−23.312	1.00	13.45	B	O
  ATOM	6192	N	MET	H	396	−9.462	−6.054	−21.877	1.00	13.06	B	N
  ATOM	6193	CA	MET	H	396	−8.356	−6.773	−22.482	1.00	13.00	B	C
  ATOM	6194	CB	MET	H	396	−7.104	−6.717	−21.605	1.00	13.34	B	C
  ATOM	6195	CG	MET	H	396	−7.052	−7.752	−20.500	1.00	14.30	B	C
  ATOM	6196	SD	MET	H	396	−5.571	−7.581	−19.484	1.00	18.50	B	S
  ATOM	6197	CE	MET	H	396	−5.752	−5.895	−18.904	1.00	17.80	B	C
  ATOM	6198	C	MET	H	396	−8.702	−8.200	−22.867	1.00	12.96	B	C
  ATOM	6199	O	MET	H	396	−9.615	−8.808	−22.309	1.00	13.04	B	O
  ATOM	6200	N	THR	H	397	−7.935	−8.734	−23.808	1.00	12.78	B	N
  ATOM	6201	CA	THR	H	397	−8.350	−9.888	−24.585	1.00	12.51	B	C
  ATOM	6202	CB	THR	H	397	−8.389	−9.563	−26.087	1.00	12.39	B	C
  ATOM	6203	OG1	THR	H	397	−9.593	−8.851	−26.394	1.00	12.50	B	O
  ATOM	6204	CG2	THR	H	397	−8.335	−10.839	−26.912	1.00	12.55	B	C
  ATOM	6205	C	THR	H	397	−7.350	−11.005	−24.366	1.00	12.58	B	C
  ATOM	6206	O	THR	H	397	−6.143	−10.772	−24.327	1.00	12.88	B	O
  ATOM	6207	N	SER	H	398	−7.859	−12.210	−24.165	1.00	12.55	B	N
  ATOM	6208	CA	SER	H	398	−7.082	−13.401	−24.410	1.00	12.76	B	C
  ATOM	6209	CB	SER	H	398	−6.083	−13.627	−23.273	1.00	12.52	B	C
  ATOM	6210	OG	SER	H	398	−5.764	−15.001	−23.133	1.00	12.72	B	O
  ATOM	6211	C	SER	H	398	−8.070	−14.539	−24.456	1.00	12.99	B	C
  ATOM	6212	O	SER	H	398	−8.838	−14.672	−25.410	1.00	13.13	B	O
  ATOM	6213	N	LYS	H	399	−8.182	−15.232	−23.330	1.00	13.01	B	N
  ATOM	6214	CA	LYS	H	399	−7.890	−16.651	−23.342	1.00	13.29	B	C
  ATOM	6215	CB	LYS	H	399	−6.739	−17.020	−24.279	1.00	13.79	B	C
  ATOM	6216	CG	LYS	H	399	−6.786	−16.279	−25.618	1.00	14.34	B	C
  ATOM	6217	CD	LYS	H	399	−7.835	−16.868	−26.552	1.00	16.43	B	C
  ATOM	6218	CE	LYS	H	399	−7.864	−16.139	−27.889	1.00	17.37	B	C
  ATOM	6219	NZ	LYS	H	399	−8.770	−16.802	−28.867	1.00	16.62	B	N
  ATOM	6220	C	LYS	H	399	−8.128	−17.609	−22.171	1.00	13.09	B	C
  ATOM	6221	O	LYS	H	399	−9.087	−18.376	−22.216	1.00	12.87	B	O
  ATOM	6222	N	THR	H		400	−7.140	−17.783	−21.300	1.00	13.04	B	N
  ATOM	6223	CA	THR	H	400	−7.133	−18.953	−20.420	1.00	13.38	B	C
  ATOM	6224	CB	THR	H	400	−5.703	−19.453	−20.133	1.00	13.74	B	C
  ATOM	6225	OG1	THR	H	400	−4.773	−18.763	−20.977	1.00	14.38	B	O
  ATOM	6226	CG2	THR	H		400	−5.601	−20.950	−20.394	1.00	14.32	B	C
  ATOM	6227	C	THR	H		400	−7.866	−18.687	−19.104	1.00	13.20	B	C
  ATOM	6228	O	THR	H	400	−7.913	−17.551	−18.630	1.00	13.12	B	O
  ATOM	6229	N	ASP	H	401	−8.478	−19.728	−18.545	1.00	12.97	B	N
  ATOM	6230	CA	ASP	H	401	−8.896	−19.715	−17.145	1.00	12.50	B	C
  ATOM	6231	CB	ASP	H	401	−9.622	−21.022	−16.798	1.00	12.73	B	C
  ATOM	6232	CG	ASP	H	401	−10.854	−21.261	−17.651	1.00	13.98	B	C
  ATOM	6233	OD1	ASP	H	401	−10.870	−20.793	−18.808	1.00	16.55	B	O
  ATOM	6234	OD2	ASP	H	401	−11.708	−22.076	−17.236	1.00	14.80	B	O
  ATOM	6235	C	ASP	H	401	−7.683	−19.567	−16.222	1.00	12.13	B	C
  ATOM	6236	O	ASP	H	401	−6.906	−20.508	−16.071	1.00	12.31	B	O
  ATOM	6237	N	VAL	H	402	−7.609	−18.459	−15.489	1.00	11.49	B	N
  ATOM	6238	CA	VAL	H	402	−7.400	−18.523	−14.044	1.00	10.74	B	C
  ATOM	6239	CB	VAL	H	402	−7.004	−17.151	−13.456	1.00	10.60	B	C
  ATOM	6240	CG1	VAL	H	402	−7.433	−17.045	−11.998	1.00	11.26	B	C
  ATOM	6241	CG2	VAL	H	402	−5.504	−16.918	−13.602	1.00	10.99	B	C
  ATOM	6242	C	VAL	H	402	−8.707	−18.986	−13.423	1.00	10.24	B	C
  ATOM	6243	O	VAL	H	402	−9.515	−19.616	−14.104	1.00	10.30	B	O
  ATOM	6244	N	SER	H	403	−9.015	−18.516	−12.218	1.00	9.76	B	N
  ATOM	6245	CA	SER	H	403	−10.286	−18.897	−11.605	1.00	9.18	B	C
  ATOM	6246	CB	SER	H	403	−10.485	−20.406	−11.726	1.00	9.41	B	C
  ATOM	6247	OG	SER	H	403	−9.349	−21.015	−12.313	1.00	10.82	B	O
  ATOM	6248	C	SER	H	403	−10.528	−18.449	−10.162	1.00	8.51	B	C
  ATOM	6249	O	SER	H	403	−9.701	−18.699	−9.285	1.00	8.30	B	O
  ATOM	6250	N	SER	H	404	−11.773	−18.053	−9.888	1.00	8.35	B	N
  ATOM	6251	CA	SER	H	404	−12.352	−18.148	−8.541	1.00	8.18	B	C
  ATOM	6252	CB	SER	H	404	−11.585	−17.257	−7.564	1.00	8.18	B	C
  ATOM	6253	OG	SER	H	404	−12.250	−16.019	−7.382	1.00	8.83	B	O
  ATOM	6254	C	SER	H	404	−13.841	−17.789	−8.505	1.00	7.62	B	C
  ATOM	6255	O	SER	H	404	−14.505	−17.759	−9.541	1.00	7.57	B	O
  ATOM	6256	N	SER	H	405	−14.357	−17.506	−7.310	1.00	7.08	B	N
  ATOM	6257	CA	SER	H	405	−15.777	−17.210	−7.151	1.00	6.53	B	C
  ATOM	6258	CB	SER	H	405	−16.568	−18.475	−6.802	1.00	6.42	B	C
  ATOM	6259	OG	SER	H	405	−17.786	−18.156	−6.146	1.00	5.66	B	O
  ATOM	6260	C	SER	H	405	−16.070	−16.101	−6.144	1.00	6.28	B	C
  ATOM	6261	O	SER	H	405	−15.289	−15.847	−5.226	1.00	5.98	B	O
  ATOM	6262	N	VAL	H	406	−17.254	−15.514	−6.281	1.00	6.22	B	N
  ATOM	6263	CA	VAL	H	406	−17.629	−14.309	−5.557	1.00	6.50	B	C
  ATOM	6264	CB	VAL	H	406	−17.390	−13.053	−6.414	1.00	6.45	B	C
  ATOM	6265	CG1	VAL	H	406	−17.384	−11.811	−5.546	1.00	7.66	B	C
  ATOM	6266	CG2	VAL	H	406	−16.090	−13.177	−7.191	1.00	7.38	B	C
  ATOM	6267	C	VAL	H	406	−19.115	−14.377	−5.237	1.00	6.24	B	C
  ATOM	6268	O	VAL	H	406	−19.946	−14.488	−6.138	1.00	6.14	B	O
  ATOM	6269	N	ILE	H	407	−19.450	−14.313	−3.955	1.00	6.32	B	N
  ATOM	6270	CA	ILE	H	407	−20.831	−14.478	−3.534	1.00	6.60	B	C
  ATOM	6271	CB	ILE	H	407	−20.925	−15.154	−2.163	1.00	6.27	B	C
  ATOM	6272	CG1	ILE	H	407	−20.643	−16.651	−2.296	1.00	6.19	B	C
  ATOM	6273	CD1	ILE	H	407	−21.477	−17.514	−1.376	1.00	8.34	B	C
  ATOM	6274	CG2	ILE	H	407	−22.294	−14.923	−1.550	1.00	6.42	B	C
  ATOM	6275	C	ILE	H	407	−21.570	−13.149	−3.497	1.00	7.20	B	C
  ATOM	6276	O	ILE	H	407	−21.094	−12.176	−2.913	1.00	7.42	B	O
  ATOM	6277	N	THR	H	408	−22.792	−13.155	−4.016	1.00	7.57	B	N
  ATOM	6278	CA	THR	H	408	−23.563	−11.933	−4.148	1.00	8.19	B	C
  ATOM	6279	CB	THR	H	408	−24.066	−11.739	−5.587	1.00	8.15	B	C
  ATOM	6280	OG1	THR	H	408	−24.863	−12.866	−5.971	1.00	8.88	B	O
  ATOM	6281	CG2	THR	H	408	−22.893	−11.606	−6.542	1.00	7.93	B	C
  ATOM	6282	C	THR	H	408	−24.753	−11.933	−3.203	1.00	8.55	B	C
  ATOM	6283	O	THR	H	408	−24.998	−12.905	−2.488	1.00	9.07	B	O
  ATOM	6284	N	SER	H	409	−25.513	−10.844	−3.238	1.00	8.70	B	N
  ATOM	6285	CA	SER	H	409	−26.644	−10.667	−2.344	1.00	9.20	B	C
  ATOM	6286	CB	SER	H	409	−27.266	−9.284	−2.543	1.00	9.72	B	C
  ATOM	6287	OG	SER	H	409	−26.279	−8.269	−2.491	1.00	10.75	B	O
  ATOM	6288	C	SER	H	409	−27.686	−11.747	−2.596	1.00	9.01	B	C
  ATOM	6289	O	SER	H	409	−28.360	−12.203	−1.671	1.00	9.02	B	O
  ATOM	6290	N	LEU	H	410	−27.804	−12.160	−3.853	1.00	8.91	B	N
  ATOM	6291	CA	LEU	H	410	−28.962	−12.921	−4.302	1.00	9.29	B	C
  ATOM	6292	CB	LEU	H	410	−29.901	−12.033	−5.118	1.00	9.61	B	C
  ATOM	6293	CG	LEU	H	410	−31.317	−11.873	−4.558	1.00	9.70	B	C
  ATOM	6294	CD1	LEU	H	410	−31.289	−11.183	−3.203	1.00	11.11	B	C
  ATOM	6295	CD2	LEU	H	410	−32.204	−11.113	−5.532	1.00	9.16	B	C
  ATOM	6296	C	LEU	H	410	−28.533	−14.134	−5.119	1.00	9.12	B	C
  ATOM	6297	O	LEU	H	410	−29.364	−14.840	−5.690	1.00	9.08	B	O
  ATOM	6298	N	GLY	H	411	−27.228	−14.365	−5.173	1.00	9.03	B	N
  ATOM	6299	CA	GLY	H	411	−26.691	−15.606	−5.706	1.00	8.44	B	C
  ATOM	6300	C	GLY	H	411	−25.180	−15.615	−5.632	1.00	7.91	B	C
  ATOM	6301	O	GLY	H	411	−24.594	−15.123	−4.668	1.00	7.85	B	O
  ATOM	6302	N	ALA	H	412	−24.546	−16.095	−6.694	1.00	7.30	B	N
  ATOM	6303	CA	ALA	H	412	−23.095	−16.167	−6.738	1.00	6.92	B	C
  ATOM	6304	CB	ALA	H	412	−22.607	−17.439	−6.062	1.00	6.90	B	C
  ATOM	6305	C	ALA	H	412	−22.593	−16.098	−8.173	1.00	6.99	B	C
  ATOM	6306	O	ALA	H	412	−23.277	−16.525	−9.102	1.00	6.94	B	O
  ATOM	6307	N	ILE	H	413	−21.415	−15.510	−8.349	1.00	7.29	B	N
  ATOM	6308	CA	ILE	H	413	−20.705	−15.567	−9.622	1.00	7.49	B	C
  ATOM	6309	CB	ILE	H	413	−20.073	−14.207	−9.961	1.00	7.24	B	C
  ATOM	6310	CG1	ILE	H	413	−21.142	−13.236	−10.466	1.00	7.18	B	C
  ATOM	6311	CD1	ILE	H	413	−20.589	−12.045	−11.233	1.00	7.70	B	C
  ATOM	6312	CG2	ILE	H	413	−18.958	−14.377	−10.983	1.00	7.70	B	C
  ATOM	6313	C	ILE	H	413	−19.596	−16.608	−9.554	1.00	7.94	B	C
  ATOM	6314	O	ILE	H	413	−18.965	−16.775	−8.512	1.00	8.39	B	O
  ATOM	6315	N	VAL	H	414	−19.276	−17.221	−10.687	1.00	8.22	B	N
  ATOM	6316	CA	VAL	H	414	−18.141	−18.134	−10.734	1.00	8.77	B	C
  ATOM	6317	CB	VAL	H	414	−18.558	−19.593	−10.482	1.00	8.57	B	C
  ATOM	6318	CG1	VAL	H	414	−19.806	−19.936	−11.279	1.00	9.12	B	C
  ATOM	6319	CG2	VAL	H	414	−17.416	−20.538	−10.825	1.00	8.90	B	C
  ATOM	6320	C	VAL	H	414	−17.323	−18.031	−12.015	1.00	8.92	B	C
  ATOM	6321	O	VAL	H	414	−17.803	−18.347	−13.105	1.00	9.00	B	O
  ATOM	6322	N	SER	H	415	−16.058	−17.659	−11.853	1.00	8.97	B	N
  ATOM	6323	CA	SER	H	415	−15.120	−17.594	−12.962	1.00	9.02	B	C
  ATOM	6324	CB	SER	H	415	−14.260	−16.335	−12.855	1.00	8.98	B	C
  ATOM	6325	OG	SER	H	415	−15.043	−15.218	−12.473	1.00	9.54	B	O
  ATOM	6326	C	SER	H	415	−14.235	−18.832	−12.987	1.00	9.36	B	C
  ATOM	6327	O	SER	H	415	−13.326	−18.975	−12.170	1.00	9.61	B	O
  ATOM	6328	N	CYS	H	416	−14.602	−19.786	−13.834	1.00	9.57	B	N
  ATOM	6329	CA	CYS	H	416	−13.851	−21.023	−13.963	1.00	9.61	B	C
  ATOM	6330	CB	CYS	H	416	−14.801	−22.216	−14.038	1.00	9.62	B	C
  ATOM	6331	SG	CYS	H	416	−14.118	−23.727	−13.341	1.00	11.33	B	S
  ATOM	6332	C	CYS	H	416	−12.998	−20.973	−15.215	1.00	9.61	B	C
  ATOM	6333	O	CYS	H	416	−13.519	−20.829	−16.320	1.00	9.80	B	O
  ATOM	6334	N	TYR	H	417	−11.684	−20.941	−15.027	1.00	9.48	B	N
  ATOM	6335	CA	TYR	H	417	−10.772	−20.739	−16.142	1.00	9.28	B	C
  ATOM	6336	CB	TYR	H	417	−10.307	−19.281	−16.205	1.00	9.17	B	C
  ATOM	6337	CG	TYR	H	417	−11.358	−18.318	−16.714	1.00	8.71	B	C
  ATOM	6338	CD1	TYR	H	417	−11.483	−17.048	−16.167	1.00	8.54	B	C
  ATOM	6339	CE1	TYR	H	417	−12.425	−16.159	−16.635	1.00	9.56	B	C
  ATOM	6340	CZ	TYR	H	417	−13.230	−16.516	−17.693	1.00	9.83	B	C
  ATOM	6341	OH	TYR	H	417	−14.184	−15.638	−18.143	1.00	10.51	B	O
  ATOM	6342	CE2	TYR	H	417	−13.122	−17.765	−18.263	1.00	9.36	B	C
  ATOM	6343	CD2	TYR	H	417	−12.177	−18.651	−17.786	1.00	8.95	B	C
  ATOM	6344	C	TYR	H	417	−9.572	−21.677	−16.068	1.00	9.35	B	C
  ATOM	6345	O	TYR	H	417	−9.336	−22.318	−15.044	1.00	9.11	B	O
  ATOM	6346	N	GLY	H	418	−8.830	−21.762	−17.169	1.00	9.71	B	N
  ATOM	6347	CA	GLY	H	418	−7.678	−22.656	−17.263	1.00	9.95	B	C
  ATOM	6348	C	GLY	H	418	−8.045	−24.101	−16.993	1.00	10.09	B	C
  ATOM	6349	O	GLY	H	418	−9.082	−24.584	−17.450	1.00	10.17	B	O
  ATOM	6350	N	LYS	H	419	−7.251	−24.756	−16.154	1.00	10.17	B	N
  ATOM	6351	CA	LYS	H	419	−7.426	−26.177	−15.896	1.00	10.50	B	C
  ATOM	6352	CB	LYS	H	419	−6.086	−26.827	−15.545	1.00	11.09	B	C
  ATOM	6353	CG	LYS	H	419	−5.332	−27.389	−16.738	1.00	12.94	B	C
  ATOM	6354	CD	LYS	H	419	−4.265	−28.377	−16.297	1.00	15.52	B	C
  ATOM	6355	CE	LYS	H		419	−3.705	−29.152	−17.479	1.00	17.07	B	C
  ATOM	6356	NZ	LYS	H	419	−3.179	−28.247	−18.538	1.00	19.30	B	N
  ATOM	6357	C	LYS	H	419	−8.447	−26.465	−14.798	1.00	10.23	B	C
  ATOM	6358	O	LYS	H		419	−8.613	−27.616	−14.398	1.00	10.58	B	O
  ATOM	6359	N	THR	H	420	−9.070	−25.426	−14.250	1.00	10.10	B	N
  ATOM	6360	CA	THR	H	420	−9.805	−25.587	−12.997	1.00	9.74	B	C
  ATOM	6361	CB	THR	H	420	−9.938	−24.270	−12.223	1.00	9.28	B	C
  ATOM	6362	OG1	THR	H		420	−9.022	−23.306	−12.754	1.00	9.21	B	O
  ATOM	6363	CG2	THR	H		420	−9.633	−24.499	−10.752	1.00	9.03	B	C
  ATOM	6364	C	THR	H	420	−11.181	−26.223	−13.168	1.00	9.95	B	C
  ATOM	6365	O	THR	H	420	−11.779	−26.160	−14.242	1.00	10.35	B	O
  ATOM	6366	N	LYS	H	421	−11.652	−26.879	−12.111	1.00	10.07	B	N
  ATOM	6367	CA	LYS	H	421	−12.961	−27.527	−12.115	1.00	10.21	B	C
  ATOM	6368	CB	LYS	H	421	−12.835	−28.979	−11.649	1.00	10.30	B	C
  ATOM	6369	CG	LYS	H	421	−12.705	−29.989	−12.776	1.00	12.43	B	C
  ATOM	6370	CD	LYS	H	421	−12.482	−31.391	−12.234	1.00	15.12	B	C
  ATOM	6371	CE	LYS	H	421	−11.769	−32.267	−13.251	1.00	15.21	B	C
  ATOM	6372	NZ	LYS	H	421	−11.047	−33.396	−12.601	1.00	15.98	B	N
  ATOM	6373	C	LYS	H	421	−13.933	−26.782	−11.206	1.00	10.09	B	C
  ATOM	6374	O	LYS	H	421	−13.600	−26.456	−10.067	1.00	10.36	B	O
  ATOM	6375	N	CYS	H	422	−15.155	−26.574	−11.685	1.00	9.81	B	N
  ATOM	6376	CA	CYS	H	422	−16.153	−25.863	−10.898	1.00	9.56	B	C
  ATOM	6377	CB	CYS	H	422	−16.222	−24.392	−11.302	1.00	9.72	B	C
  ATOM	6378	SG	CYS	H	422	−14.611	−23.591	−11.379	1.00	11.42	B	S
  ATOM	6379	C	CYS	H	422	−17.535	−26.499	−10.939	1.00	9.18	B	C
  ATOM	6380	O	CYS	H	422	−17.952	−27.056	−11.954	1.00	9.27	B	O
  ATOM	6381	N	THR	H	423	−18.273	−26.311	−9.851	1.00	8.93	B	N
  ATOM	6382	CA	THR	H	423	−19.417	−27.147	−9.527	1.00	8.64	B	C
  ATOM	6383	CB	THR	H	423	−19.014	−28.315	−8.606	1.00	8.32	B	C
  ATOM	6384	OG1	THR	H	423	−17.878	−28.993	−9.154	1.00	7.97	B	O
  ATOM	6385	CG2	THR	H	423	−20.165	−29.297	−8.456	1.00	8.36	B	C
  ATOM	6386	C	THR	H	423	−20.441	−26.297	−8.791	1.00	8.86	B	C
  ATOM	6387	O	THR	H	423	−20.133	−25.694	−7.763	1.00	9.26	B	O
  ATOM	6388	N	ALA	H	424	−21.676	−26.306	−9.279	1.00	8.74	B	N
  ATOM	6389	CA	ALA	H	424	−22.803	−25.836	−8.487	1.00	8.79	B	C
  ATOM	6390	CB	ALA	H	424	−23.693	−24.926	−9.317	1.00	8.94	B	C
  ATOM	6391	C	ALA	H	424	−23.605	−27.008	−7.932	1.00	8.84	B	C
  ATOM	6392	O	ALA	H	424	−24.158	−27.807	−8.687	1.00	9.24	B	O
  ATOM	6393	N	SER	H	425	−23.649	−27.113	−6.608	1.00	8.81	B	N
  ATOM	6394	CA	SER	H	425	−24.412	−28.166	−5.950	1.00	8.85	B	C
  ATOM	6395	CB	SER	H	425	−23.530	−28.925	−4.957	1.00	8.94	B	C
  ATOM	6396	OG	SER	H	425	−22.166	−28.871	−5.341	1.00	7.69	B	O
  ATOM	6397	C	SER	H	425	−25.626	−27.584	−5.235	1.00	9.01	B	C
  ATOM	6398	O	SER	H	425	−25.593	−26.447	−4.763	1.00	8.63	B	O
  ATOM	6399	N	ASN	H	426	−26.716	−28.345	−5.208	1.00	9.54	B	N
  ATOM	6400	CA	ASN	H	426	−27.971	−27.851	−4.658	1.00	10.19	B	C
  ATOM	6401	CB	ASN	H	426	−29.166	−28.508	−5.356	1.00	9.77	B	C
  ATOM	6402	CG	ASN	H	426	−29.499	−29.874	−4.787	1.00	9.43	B	C
  ATOM	6403	OD1	ASN	H	426	−28.998	−30.259	−3.730	1.00	9.01	B	O
  ATOM	6404	ND2	ASN	H	426	−30.349	−30.615	−5.488	1.00	9.01	B	N
  ATOM	6405	C	ASN	H	426	−28.074	−28.031	−3.146	1.00	11.16	B	C
  ATOM	6406	O	ASN	H	426	−27.072	−28.247	−2.463	1.00	11.06	B	O
  ATOM	6407	N	LYS	H	427	−29.285	−27.847	−2.628	1.00	12.38	B	N
  ATOM	6408	CA	LYS	H	427	−29.569	−27.993	−1.203	1.00	13.52	B	C
  ATOM	6409	CB	LYS	H	427	−31.082	−28.017	−0.968	1.00	14.00	B	C
  ATOM	6410	CG	LYS	H	427	−31.681	−26.675	−0.585	1.00	16.18	B	C
  ATOM	6411	CD	LYS	H	427	−33.105	−26.838	−0.078	1.00	18.24	B	C
  ATOM	6412	CE	LYS	H	427	−33.487	−25.714	0.870	1.00	19.72	B	C
  ATOM	6413	NZ	LYS	H	427	−32.873	−25.888	2.216	1.00	21.43	B	N
  ATOM	6414	C	LYS	H	427	−28.943	−29.256	−0.621	1.00	13.71	B	C
  ATOM	6415	O	LYS	H	427	−28.329	−29.220	0.446	1.00	13.63	B	O
  ATOM	6416	N	ASN	H	428	−29.233	−30.390	−1.252	1.00	14.28	B	N
  ATOM	6417	CA	ASN	H	428	−28.838	−31.694	−0.729	1.00	14.60	B	C
  ATOM	6418	CB	ASN	H	428	−29.715	−32.800	−1.324	1.00	14.57	B	C
  ATOM	6419	CG	ASN	H	428	−31.103	−32.312	−1.690	1.00	13.24	B	C
  ATOM	6420	OD1	ASN	H	428	−31.832	−31.790	−0.846	1.00	9.74	B	O
  ATOM	6421	ND2	ASN	H	428	−31.503	−32.546	−2.935	1.00	12.83	B	N
  ATOM	6422	C	ASN	H	428	−27.367	−32.009	−0.984	1.00	14.83	B	C
  ATOM	6423	O	ASN	H	428	−26.834	−32.982	−0.451	1.00	15.25	B	O
  ATOM	6424	N	ARG	H	429	−26.755	−31.260	−1.895	1.00	14.78	B	N
  ATOM	6425	CA	ARG	H	429	−25.364	−31.488	−2.275	1.00	14.74	B	C
  ATOM	6426	CB	ARG	H	429	−24.626	−32.268	−1.184	1.00	14.93	B	C
  ATOM	6427	CG	ARG	H	429	−24.252	−31.435	0.031	1.00	16.26	B	C
  ATOM	6428	CD	ARG	H	429	−22.869	−30.821	−0.119	1.00	19.79	B	C
  ATOM	6429	NE	ARG	H	429	−22.634	−29.760	0.857	1.00	22.68	B	N
  ATOM	6430	CZ	ARG	H	429	−22.532	−29.958	2.167	1.00	23.54	B	C
  ATOM	6431	NH1	ARG	H	429	−22.640	−31.182	2.667	1.00	22.87	B	N
  ATOM	6432	NH2	ARG	H	429	−22.321	−28.932	2.980	1.00	23.53	B	N
  ATOM	6433	C	ARG	H	429	−25.252	−32.217	−3.611	1.00	14.35	B	C
  ATOM	6434	O	ARG	H	429	−24.175	−32.285	−4.203	1.00	14.62	B	O
  ATOM	6435	N	GLY	H	430	−26.373	−32.752	−4.085	1.00	13.67	B	N
  ATOM	6436	CA	GLY	H	430	−26.519	−33.087	−5.496	1.00	12.80	B	C
  ATOM	6437	C	GLY	H	430	−26.014	−31.977	−6.397	1.00	12.11	B	C
  ATOM	6438	O	GLY	H	430	−26.326	−30.805	−6.188	1.00	12.18	B	O
  ATOM	6439	N	ILE	H	431	−25.216	−32.346	−7.393	1.00	11.58	B	N
  ATOM	6440	CA	ILE	H	431	−24.551	−31.372	−8.251	1.00	10.76	B	C
  ATOM	6441	CB	ILE	H	431	−23.175	−31.896	−8.715	1.00	10.43	B	C
  ATOM	6442	CG1	ILE	H	431	−22.220	−32.024	−7.527	1.00	10.95	B	C
  ATOM	6443	CD1	ILE	H	431	−21.220	−33.153	−7.665	1.00	12.08	B	C
  ATOM	6444	CG2	ILE	H	431	−22.592	−30.993	−9.791	1.00	10.07	B	C
  ATOM	6445	C	ILE	H	431	−25.406	−31.085	−9.484	1.00	10.68	B	C
  ATOM	6446	O	ILE	H	431	−25.703	−31.994	−10.258	1.00	10.40	B	O
  ATOM	6447	N	ILE	H	432	−25.852	−29.840	−9.636	1.00	10.90	B	N
  ATOM	6448	CA	ILE	H	432	−26.692	−29.481	−10.779	1.00	11.42	B	C
  ATOM	6449	CB	ILE	H	432	−27.709	−28.375	−10.448	1.00	11.63	B	C
  ATOM	6450	CG1	ILE	H	432	−27.875	−28.224	−8.936	1.00	12.68	B	C
  ATOM	6451	CD1	ILE	H	432	−28.514	−26.915	−8.524	1.00	13.89	B	C
  ATOM	6452	CG2	ILE	H	432	−29.046	−28.664	−11.116	1.00	12.24	B	C
  ATOM	6453	C	ILE	H	432	−25.884	−29.045	−11.993	1.00	11.41	B	C
  ATOM	6454	O	ILE	H	432	−26.225	−29.395	−13.123	1.00	11.63	B	O
  ATOM	6455	N	LYS	H	433	−24.982	−28.093	−11.782	1.00	11.52	B	N
  ATOM	6456	CA	LYS	H	433	−24.226	−27.523	−12.888	1.00	11.96	B	C
  ATOM	6457	CB	LYS	H	433	−24.433	−26.010	−12.976	1.00	12.31	B	C
  ATOM	6458	CG	LYS	H	433	−23.850	−25.387	−14.237	1.00	14.42	B	C
  ATOM	6459	CD	LYS	H	433	−24.649	−24.175	−14.685	1.00	16.74	B	C
  ATOM	6460	CE	LYS	H	433	−24.112	−23.613	−15.993	1.00	17.08	B	C
  ATOM	6461	NZ	LYS	H	433	−24.993	−23.949	−17.146	1.00	17.30	B	N
  ATOM	6462	C	LYS	H	433	−22.743	−27.850	−12.793	1.00	11.65	B	C
  ATOM	6463	O	LYS	H	433	−22.248	−28.250	−11.740	1.00	11.48	B	O
  ATOM	6464	N	THR	H	434	−22.052	−27.731	−13.921	1.00	11.28	B	N
  ATOM	6465	CA	THR	H	434	−20.617	−27.970	−13.975	1.00	11.21	B	C
  ATOM	6466	CB	THR	H	434	−20.308	−29.467	−14.165	1.00	11.30	B	C
  ATOM	6467	OG1	THR	H	434	−18.945	−29.629	−14.574	1.00	11.83	B	O
  ATOM	6468	CG2	THR	H	434	−21.224	−30.071	−15.220	1.00	11.84	B	C
  ATOM	6469	C	THR	H	434	−20.009	−27.185	−15.131	1.00	10.94	B	C
  ATOM	6470	O	THR	H	434	−20.623	−27.060	−16.190	1.00	10.93	B	O
  ATOM	6471	N	PHE	H	435	−18.867	−26.549	−14.886	1.00	11.10	B	N
  ATOM	6472	CA	PHE	H	435	−18.610	−25.235	−15.464	1.00	11.96	B	C
  ATOM	6473	CB	PHE	H	435	−18.186	−24.223	−14.401	1.00	11.51	B	C
  ATOM	6474	CG	PHE	H	435	−19.344	−23.561	−13.710	1.00	11.19	B	C
  ATOM	6475	CD1	PHE	H	435	−19.580	−23.788	−12.365	1.00	10.86	B	C
  ATOM	6476	CE1	PHE	H	435	−20.692	−23.253	−11.741	1.00	10.24	B	C
  ATOM	6477	CZ	PHE	H	435	−21.613	−22.532	−12.474	1.00	9.89	B	C
  ATOM	6478	CE2	PHE	H	435	−21.420	−22.347	−13.828	1.00	10.78	B	C
  ATOM	6479	CD2	PHE	H	435	−20.304	−22.884	−14.445	1.00	11.14	B	C
  ATOM	6480	C	PHE	H	435	−17.694	−25.202	−16.684	1.00	13.00	B	C
  ATOM	6481	O	PHE	H	435	−16.525	−25.587	−16.618	1.00	13.03	B	O
  ATOM	6482	N	SER	H	436	−18.199	−24.569	−17.738	1.00	13.89	B	N
  ATOM	6483	CA	SER	H	436	−17.549	−24.549	−19.039	1.00	14.67	B	C
  ATOM	6484	CB	SER	H	436	−18.601	−24.438	−20.145	1.00	15.04	B	C
  ATOM	6485	OG	SER	H	436	−18.532	−25.539	−21.033	1.00	16.58	B	O
  ATOM	6486	C	SER	H	436	−16.586	−23.371	−19.134	1.00	14.75	B	C
  ATOM	6487	O	SER	H	436	−16.849	−22.398	−19.841	1.00	14.75	B	O
  ATOM	6488	N	ASN	H	437	−15.480	−23.451	−18.405	1.00	14.44	B	N
  ATOM	6489	CA	ASN	H	437	−14.306	−22.659	−18.736	1.00	14.35	B	C
  ATOM	6490	CB	ASN	H	437	−13.508	−23.354	−19.840	1.00	14.75	B	C
  ATOM	6491	CG	ASN	H	437	−12.101	−22.822	−19.966	1.00	15.51	B	C
  ATOM	6492	OD1	ASN	H	437	−11.290	−22.960	−19.049	1.00	16.85	B	O
  ATOM	6493	ND2	ASN	H	437	−11.757	−22.358	−21.162	1.00	16.10	B	N
  ATOM	6494	C	ASN	H	437	−14.692	−21.239	−19.161	1.00	13.69	B	C
  ATOM	6495	O	ASN	H	437	−14.402	−20.814	−20.280	1.00	13.40	B	O
  ATOM	6496	N	GLY	H	438	−15.374	−20.527	−18.267	1.00	13.39	B	N
  ATOM	6497	CA	GLY	H	438	−15.942	−19.216	−18.573	1.00	12.92	B	C
  ATOM	6498	C	GLY	H	438	−16.310	−18.455	−17.311	1.00	12.72	B	C
  ATOM	6499	O	GLY	H	438	−15.574	−18.495	−16.324	1.00	12.83	B	O
  ATOM	6500	N	CYS	H	439	−17.502	−17.863	−17.297	1.00	12.17	B	N
  ATOM	6501	CA	CYS	H	439	−17.969	−17.110	−16.134	1.00	11.52	B	C
  ATOM	6502	CB	CYS	H	439	−17.353	−15.712	−16.124	1.00	11.68	B	C
  ATOM	6503	SG	CYS	H	439	−18.500	−14.404	−16.619	1.00	12.89	B	S
  ATOM	6504	C	CYS	H	439	−19.492	−17.006	−16.079	1.00	10.95	B	C
  ATOM	6505	O	CYS	H	439	−20.102	−16.298	−16.880	1.00	10.77	B	O
  ATOM	6506	N	ASP	H	440	−20.089	−17.630	−15.066	1.00	10.41	B	N
  ATOM	6507	CA	ASP	H	440	−21.541	−17.762	−14.987	1.00	10.06	B	C
  ATOM	6508	CB	ASP	H	440	−21.953	−19.232	−15.091	1.00	10.85	B	C
  ATOM	6509	CG	ASP	H	440	−22.561	−19.576	−16.438	1.00	13.11	B	C
  ATOM	6510	OD1	ASP	H	440	−23.750	−19.260	−16.654	1.00	14.97	B	O
  ATOM	6511	OD2	ASP	H	440	−21.872	−20.227	−17.251	1.00	15.27	B	O
  ATOM	6512	C	ASP	H	440	−22.098	−17.161	−13.700	1.00	9.01	B	C
  ATOM	6513	O	ASP	H	440	−21.345	−16.790	−12.798	1.00	9.09	B	O
  ATOM	6514	N	TYR	H	441	−23.422	−17.184	−13.580	1.00	7.92	B	N
  ATOM	6515	CA	TYR	H	441	−24.117	−16.707	−12.387	1.00	7.24	B	C
  ATOM	6516	CB	TYR	H	441	−24.810	−15.371	−12.683	1.00	7.04	B	C
  ATOM	6517	CG	TYR	H	441	−25.669	−14.849	−11.556	1.00	6.77	B	C
  ATOM	6518	CD1	TYR	H	441	−25.145	−13.986	−10.605	1.00	7.41	B	C
  ATOM	6519	CE1	TYR	H	441	−25.927	−13.498	−9.579	1.00	6.79	B	C
  ATOM	6520	CZ	TYR	H	441	−27.270	−13.809	−9.539	1.00	6.49	B	C
  ATOM	6521	OH	TYR	H	441	−28.049	−13.340	−8.507	1.00	5.09	B	O
  ATOM	6522	CE2	TYR	H	441	−27.823	−14.634	−10.494	1.00	7.52	B	C
  ATOM	6523	CD2	TYR	H	441	−27.029	−15.122	−11.512	1.00	7.12	B	C
  ATOM	6524	C	TYR	H	441	−25.153	−17.748	−11.974	1.00	6.89	B	C
  ATOM	6525	O	TYR	H	441	−25.720	−18.436	−12.823	1.00	7.12	B	O
  ATOM	6526	N	VAL	H	442	−25.353	−17.906	−10.670	1.00	6.73	B	N
  ATOM	6527	CA	VAL	H	442	−26.400	−18.784	−10.159	1.00	6.78	B	C
  ATOM	6528	CB	VAL	H	442	−25.808	−20.089	−9.596	1.00	6.51	B	C
  ATOM	6529	CG1	VAL	H	442	−25.394	−21.017	−10.729	1.00	7.38	B	C
  ATOM	6530	CG2	VAL	H	442	−24.625	−19.786	−8.688	1.00	6.00	B	C
  ATOM	6531	C	VAL	H	442	−27.167	−18.062	−9.059	1.00	7.13	B	C
  ATOM	6532	O	VAL	H	442	−26.774	−16.973	−8.643	1.00	7.77	B	O
  ATOM	6533	N	SER	H	443	−28.229	−18.679	−8.552	1.00	7.12	B	N
  ATOM	6534	CA	SER	H	443	−29.017	−18.039	−7.504	1.00	7.64	B	C
  ATOM	6535	CB	SER	H	443	−30.184	−17.252	−8.104	1.00	7.83	B	C
  ATOM	6536	OG	SER	H	443	−31.411	−17.936	−7.922	1.00	7.99	B	O
  ATOM	6537	C	SER	H	443	−29.508	−18.989	−6.415	1.00	8.16	B	C
  ATOM	6538	O	SER	H	443	−29.421	−20.210	−6.552	1.00	8.69	B	O
  ATOM	6539	N	ASN	H	444	−29.959	−18.412	−5.306	1.00	8.73	B	N
  ATOM	6540	CA	ASN	H	444	−30.539	−19.184	−4.213	1.00	9.50	B	C
  ATOM	6541	CB	ASN	H	444	−30.766	−18.297	−2.984	1.00	9.65	B	C
  ATOM	6542	CG	ASN	H	444	−29.895	−17.053	−2.990	1.00	10.64	B	C
  ATOM	6543	OD1	ASN	H	444	−28.780	−17.060	−3.516	1.00	12.28	B	O
  ATOM	6544	ND2	ASN	H	444	−30.414	−15.966	−2.426	1.00	11.75	B	N
  ATOM	6545	C	ASN	H	444	−31.843	−19.863	−4.618	1.00	10.24	B	C
  ATOM	6546	O	ASN	H	444	−32.618	−19.317	−5.403	1.00	9.89	B	O
  ATOM	6547	N	LYS	H	445	−32.146	−20.975	−3.955	1.00	11.63	B	N
  ATOM	6548	CA	LYS	H	445	−32.826	−22.105	−4.588	1.00	13.07	B	C
  ATOM	6549	CB	LYS	H	445	−34.344	−21.990	−4.421	1.00	13.70	B	C
  ATOM	6550	CG	LYS	H	445	−35.131	−23.200	−4.915	1.00	15.80	B	C
  ATOM	6551	CD	LYS	H	445	−34.354	−24.501	−4.753	1.00	18.31	B	C
  ATOM	6552	CE	LYS	H	445	−33.508	−24.498	−3.490	1.00	19.03	B	C
  ATOM	6553	NZ	LYS	H	445	−34.316	−24.206	−2.274	1.00	20.02	B	N
  ATOM	6554	C	LYS	H	445	−32.459	−22.265	−6.060	1.00	12.96	B	C
  ATOM	6555	O	LYS	H	445	−32.290	−21.282	−6.780	1.00	13.24	B	O
  ATOM	6556	N	GLY	H	446	−32.350	−23.513	−6.504	1.00	13.08	B	N
  ATOM	6557	CA	GLY	H	446	−31.215	−23.936	−7.312	1.00	12.42	B	C
  ATOM	6558	C	GLY	H	446	−29.988	−24.163	−6.453	1.00	11.83	B	C
  ATOM	6559	O	GLY	H	446	−29.855	−25.209	−5.819	1.00	12.44	B	O
  ATOM	6560	N	VAL	H	447	−29.191	−23.114	−6.285	1.00	10.63	B	N
  ATOM	6561	CA	VAL	H	447	−27.809	−23.277	−5.857	1.00	10.01	B	C
  ATOM	6562	CB	VAL	H	447	−26.839	−22.442	−6.711	1.00	9.97	B	C
  ATOM	6563	CG1	VAL	H	447	−25.405	−22.896	−6.479	1.00	10.51	B	C
  ATOM	6564	CG2	VAL	H	447	−27.204	−22.551	−8.183	1.00	10.50	B	C
  ATOM	6565	C	VAL	H	447	−27.603	−22.962	−4.380	1.00	9.53	B	C
  ATOM	6566	O	VAL	H	447	−28.099	−21.957	−3.868	1.00	9.61	B	O
  ATOM	6567	N	ASP	H	448	−26.719	−23.735	−3.760	1.00	9.16	B	N
  ATOM	6568	CA	ASP	H	448	−26.522	−23.714	−2.318	1.00	8.75	B	C
  ATOM	6569	CB	ASP	H	448	−27.139	−24.971	−1.698	1.00	9.22	B	C
  ATOM	6570	CG	ASP	H	448	−27.482	−24.795	−0.234	1.00	11.44	B	C
  ATOM	6571	OD1	ASP	H	448	−26.877	−23.921	0.421	1.00	13.83	B	O
  ATOM	6572	OD2	ASP	H	448	−28.319	−25.568	0.276	1.00	14.13	B	O
  ATOM	6573	C	ASP	H	448	−25.020	−23.714	−2.076	1.00	8.18	B	C
  ATOM	6574	O	ASP	H	448	−24.528	−23.151	−1.098	1.00	8.06	B	O
  ATOM	6575	N	THR	H	449	−24.298	−24.280	−3.036	1.00	7.63	B	N
  ATOM	6576	CA	THR	H	449	−22.858	−24.437	−2.940	1.00	6.80	B	C
  ATOM	6577	CB	THR	H	449	−22.485	−25.824	−2.386	1.00	6.89	B	C
  ATOM	6578	OG1	THR	H	449	−22.377	−25.758	−0.959	1.00	6.16	B	O
  ATOM	6579	CG2	THR	H	449	−21.163	−26.296	−2.970	1.00	7.55	B	C
  ATOM	6580	C	THR	H	449	−22.265	−24.297	−4.333	1.00	6.53	B	C
  ATOM	6581	O	THR	H	449	−22.828	−24.792	−5.309	1.00	6.59	B	O
  ATOM	6582	N	VAL	H		450	−21.145	−23.594	−4.428	1.00	6.07	B	N
  ATOM	6583	CA	VAL	H	450	−20.209	−23.829	−5.512	1.00	6.02	B	C
  ATOM	6584	CB	VAL	H	450	−20.064	−22.597	−6.420	1.00	5.61	B	C
  ATOM	6585	CG1	VAL	H	450	−21.429	−22.130	−6.904	1.00	5.32	B	C
  ATOM	6586	CG2	VAL	H	450	−19.339	−21.481	−5.687	1.00	5.55	B	C
  ATOM	6587	C	VAL	H	450	−18.853	−24.210	−4.950	1.00	6.37	B	C
  ATOM	6588	O	VAL	H		450	−18.503	−23.827	−3.833	1.00	6.54	B	O
  ATOM	6589	N	SER	H	451	−18.176	−25.110	−5.649	1.00	6.41	B	N
  ATOM	6590	CA	SER	H	451	−16.786	−25.397	−5.362	1.00	6.70	B	C
  ATOM	6591	CB	SER	H	451	−16.602	−26.886	−5.069	1.00	7.13	B	C
  ATOM	6592	OG	SER	H	451	−17.729	−27.629	−5.498	1.00	9.26	B	O
  ATOM	6593	C	SER	H	451	−15.944	−24.990	−6.555	1.00	6.47	B	C
  ATOM	6594	O	SER	H	451	−16.363	−25.147	−7.701	1.00	6.54	B	O
  ATOM	6595	N	VAL	H	452	−14.861	−24.277	−6.276	1.00	6.56	B	N
  ATOM	6596	CA	VAL	H	452	−13.801	−24.112	−7.251	1.00	6.31	B	C
  ATOM	6597	CB	VAL	H	452	−13.469	−22.625	−7.471	1.00	5.74	B	C
  ATOM	6598	CG1	VAL	H	452	−12.757	−22.433	−8.801	1.00	5.06	B	C
  ATOM	6599	CG2	VAL	H	452	−14.740	−21.787	−7.420	1.00	5.56	B	C
  ATOM	6600	C	VAL	H	452	−12.558	−24.861	−6.791	1.00	6.60	B	C
  ATOM	6601	O	VAL	H	452	−12.130	−24.726	−5.644	1.00	7.04	B	O
  ATOM	6602	N	GLY	H	453	−12.047	−25.732	−7.654	1.00	6.54	B	N
  ATOM	6603	CA	GLY	H	453	−11.013	−26.672	−7.250	1.00	6.43	B	C
  ATOM	6604	C	GLY	H	453	−11.329	−27.255	−5.889	1.00	6.09	B	C
  ATOM	6605	O	GLY	H	453	−12.396	−27.836	−5.690	1.00	5.90	B	O
  ATOM	6606	N	ASN	H	454	−10.479	−26.962	−4.913	1.00	6.02	B	N
  ATOM	6607	CA	ASN	H	454	−10.646	−27.533	−3.585	1.00	6.39	B	C
  ATOM	6608	CB	ASN	H	454	−9.330	−28.111	−3.073	1.00	6.81	B	C
  ATOM	6609	CG	ASN	H	454	−9.190	−29.585	−3.382	1.00	8.99	B	C
  ATOM	6610	OD1	ASN	H	454	−9.587	−30.433	−2.584	1.00	11.67	B	O
  ATOM	6611	ND2	ASN	H	454	−8.782	−29.893	−4.609	1.00	10.25	B	N
  ATOM	6612	C	ASN	H	454	−11.235	−26.563	−2.573	1.00	6.15	B	C
  ATOM	6613	O	ASN	H	454	−11.623	−26.963	−1.475	1.00	6.47	B	O
  ATOM	6614	N	THR	H	455	−11.406	−25.312	−2.985	1.00	5.40	B	N
  ATOM	6615	CA	THR	H	455	−12.129	−24.347	−2.172	1.00	4.53	B	C
  ATOM	6616	CB	THR	H	455	−11.775	−22.902	−2.551	1.00	4.70	B	C
  ATOM	6617	OG1	THR	H	455	−10.351	−22.746	−2.567	1.00	5.28	B	O
  ATOM	6618	CG2	THR	H	455	−12.374	−21.928	−1.542	1.00	5.57	B	C
  ATOM	6619	C	THR	H	455	−13.632	−24.543	−2.293	1.00	4.01	B	C
  ATOM	6620	O	THR	H	455	−14.139	−24.921	−3.349	1.00	3.78	B	O
  ATOM	6621	N	LEU	H	456	−14.338	−24.306	−1.194	1.00	3.87	B	N
  ATOM	6622	CA	LEU	H	456	−15.787	−24.419	−1.181	1.00	4.05	B	C
  ATOM	6623	CB	LEU	H	456	−16.232	−25.520	−0.219	1.00	3.95	B	C
  ATOM	6624	CG	LEU	H	456	−17.708	−25.915	−0.306	1.00	3.76	B	C
  ATOM	6625	CD1	LEU	H	456	−18.042	−26.440	−1.694	1.00	5.35	B	C
  ATOM	6626	CD2	LEU	H	456	−18.053	−26.944	0.758	1.00	4.10	B	C
  ATOM	6627	C	LEU	H	456	−16.439	−23.097	−0.802	1.00	4.47	B	C
  ATOM	6628	O	LEU	H	456	−16.186	−22.551	0.272	1.00	4.94	B	O
  ATOM	6629	N	TYR	H	457	−17.343	−22.634	−1.657	1.00	4.59	B	N
  ATOM	6630	CA	TYR	H	457	−18.102	−21.425	−1.386	1.00	4.60	B	C
  ATOM	6631	CB	TYR	H	457	−17.996	−20.463	−2.570	1.00	4.71	B	C
  ATOM	6632	CG	TYR	H	457	−16.594	−19.949	−2.820	1.00	5.62	B	C
  ATOM	6633	CD1	TYR	H	457	−15.657	−20.727	−3.485	1.00	7.09	B	C
  ATOM	6634	CE1	TYR	H	457	−14.388	−20.247	−3.748	1.00	8.22	B	C
  ATOM	6635	CZ	TYR	H	457	−14.029	−18.994	−3.305	1.00	8.06	B	C
  ATOM	6636	OH	TYR	H	457	−12.763	−18.520	−3.550	1.00	8.80	B	O
  ATOM	6637	CE2	TYR	H	457	−14.933	−18.212	−2.622	1.00	7.18	B	C
  ATOM	6638	CD2	TYR	H	457	−16.203	−18.694	−2.375	1.00	6.66	B	C
  ATOM	6639	C	TYR	H	457	−19.565	−21.758	−1.099	1.00	4.46	B	C
  ATOM	6640	O	TYR	H	457	−20.180	−22.551	−1.811	1.00	4.92	B	O
  ATOM	6641	N	TYR	H	458	−20.098	−21.196	−0.017	1.00	3.90	B	N
  ATOM	6642	CA	TYR	H	458	−21.496	−21.408	0.366	1.00	3.26	B	C
  ATOM	6643	CB	TYR	H	458	−21.610	−21.544	1.885	1.00	3.16	B	C
  ATOM	6644	CG	TYR	H	458	−20.863	−22.722	2.457	1.00	3.29	B	C
  ATOM	6645	CD1	TYR	H	458	−19.547	−22.597	2.881	1.00	3.93	B	C
  ATOM	6646	CE1	TYR	H	458	−18.866	−23.672	3.419	1.00	4.90	B	C
  ATOM	6647	CZ	TYR	H	458	−19.501	−24.890	3.535	1.00	5.12	B	C
  ATOM	6648	OH	TYR	H	458	−18.826	−25.967	4.062	1.00	5.42	B	O
  ATOM	6649	CE2	TYR	H	458	−20.810	−25.036	3.128	1.00	4.72	B	C
  ATOM	6650	CD2	TYR	H	458	−21.483	−23.955	2.598	1.00	3.89	B	C
  ATOM	6651	C	TYR	H	458	−22.372	−20.242	−0.085	1.00	3.04	B	C
  ATOM	6652	O	TYR	H	458	−22.185	−19.119	0.378	1.00	3.37	B	O
  ATOM	6653	N	VAL	H	459	−23.453	−20.542	−0.800	1.00	2.71	B	N
  ATOM	6654	CA	VAL	H	459	−24.073	−19.546	−1.678	1.00	2.61	B	C
  ATOM	6655	CB	VAL	H	459	−24.381	−20.115	−3.067	1.00	2.22	B	C
  ATOM	6656	CG1	VAL	H	459	−25.021	−19.042	−3.938	1.00	2.62	B	C
  ATOM	6657	CG2	VAL	H	459	−23.123	−20.656	−3.716	1.00	2.61	B	C
  ATOM	6658	C	VAL	H	459	−25.372	−18.924	−1.190	1.00	3.03	B	C
  ATOM	6659	O	VAL	H	459	−25.418	−18.348	−0.103	1.00	3.21	B	O
  ATOM	6660	N	ASN	H	460	−26.215	−18.648	−2.185	1.00	106.93	B	N
  ATOM	6661	CA	ASN	H	460	−27.625	−18.431	−1.941	1.00	95.54	B	C
  ATOM	6662	CB	ASN	H	460	−27.810	−17.878	−0.542	1.00	20.00	B	C
  ATOM	6663	CG	ASN	H	460	−28.967	−18.507	0.162	1.00	20.00	B	C
  ATOM	6664	OD1	ASN	H	460	−29.655	−19.349	−0.416	1.00	20.00	B	O
  ATOM	6665	ND2	ASN	H	460	−29.359	−17.912	1.280	1.00	20.00	B	N
  ATOM	6666	C	ASN	H	460	−28.426	−17.612	−2.969	1.00	99.41	B	C
  ATOM	6667	O	ASN	H	460	−29.222	−18.178	−3.718	1.00	108.91	B	O
  ATOM	6668	N	LYS	H	461	−28.370	−16.283	−2.861	1.00	97.04	B	N
  ATOM	6669	CA	LYS	H	461	−29.458	−15.387	−3.306	1.00	105.93	B	C
  ATOM	6670	CB	LYS	H	461	−29.011	−13.925	−3.219	1.00	20.00	B	C
  ATOM	6671	CG	LYS	H	461	−28.633	−13.460	−1.820	1.00	20.00	B	C
  ATOM	6672	CD	LYS	H	461	−27.794	−12.187	−1.865	1.00	20.00	B	C
  ATOM	6673	CE	LYS	H	461	−27.646	−11.565	−0.482	1.00	20.00	B	C
  ATOM	6674	NZ	LYS	H	461	−26.746	−10.375	−0.482	1.00	20.00	B	N
  ATOM	6675	C	LYS	H	461	−30.025	−15.676	−4.708	1.00	102.28	B	C
  ATOM	6676	O	LYS	H	461	−29.779	−16.739	−5.276	1.00	105.02	B	O
  ATOM	6677	N	GLN	H	462	−30.766	−14.715	−5.266	1.00	96.68	B	N
  ATOM	6678	CA	GLN	H	462	−31.286	−14.810	−6.641	1.00	105.71	B	C
  ATOM	6679	CB	GLN	H	462	−32.787	−15.128	−6.624	1.00	20.00	B	C
  ATOM	6680	CG	GLN	H	462	−33.142	−16.522	−6.122	1.00	20.00	B	C
  ATOM	6681	CD	GLN	H	462	−34.637	−16.794	−6.159	1.00	20.00	B	C
  ATOM	6682	OE1	GLN	H	462	−35.450	−15.870	−6.115	1.00	20.00	B	O
  ATOM	6683	NE2	GLN	H	462	−35.006	−18.068	−6.230	1.00	20.00	B	N
  ATOM	6684	C	GLN	H	462	−31.052	−13.514	−7.429	1.00	101.50	B	C
  ATOM	6685	O	GLN	H	462	−31.398	−12.430	−6.960	1.00	105.94	B	O
  ATOM	6686	N	GLU	H	463	−30.565	−13.634	−8.663	1.00	98.92	B	N
  ATOM	6687	CA	GLU	H	463	−30.241	−12.453	−9.465	1.00	108.59	B	C
  ATOM	6688	CB	GLU	H	463	−28.792	−12.505	−9.966	1.00	20.00	B	C
  ATOM	6689	CG	GLU	H	463	−27.767	−11.973	−8.957	1.00	20.00	B	C
  ATOM	6690	CD	GLU	H	463	−26.341	−11.973	−9.490	1.00	20.00	B	C
  ATOM	6691	OE1	GLU	H	463	−26.167	−11.917	−10.729	1.00	20.00	B	O
  ATOM	6692	OE2	GLU	H	463	−25.399	−11.890	−8.672	1.00	20.00	B	O
  ATOM	6693	C	GLU	H	463	−31.208	−12.245	−10.629	1.00	116.39	B	C
  ATOM	6694	O	GLU	H	463	−31.442	−13.153	−11.426	1.00	118.70	B	O
  ATOM	6695	N	GLY	H	464	−31.759	−11.039	−10.722	1.00	127.70	B	N
  ATOM	6696	CA	GLY	H	464	−32.671	−10.693	−11.806	1.00	143.17	B	C
  ATOM	6697	C	GLY	H	464	−31.941	−10.347	−13.089	1.00	149.77	B	C
  ATOM	6698	O	GLY	H	464	−30.719	−10.197	−13.098	1.00	155.06	B	O
  ATOM	6699	N	LYS	H	465	−32.694	−10.223	−14.178	1.00	153.73	B	N
  ATOM	6700	CA	LYS	H	465	−32.115	−9.929	−15.484	1.00	153.69	B	C
  ATOM	6701	CB	LYS	H	465	−31.275	−8.651	−15.424	1.00	20.00	B	C
  ATOM	6702	CG	LYS	H	465	−32.085	−7.385	−15.193	1.00	20.00	B	C
  ATOM	6703	CD	LYS	H	465	−31.186	−6.163	−15.106	1.00	20.00	B	C
  ATOM	6704	CE	LYS	H	465	−31.995	−4.898	−14.868	1.00	20.00	B	C
  ATOM	6705	NZ	LYS	H	465	−31.127	−3.692	−14.776	1.00	20.00	B	N
  ATOM	6706	C	LYS	H	465	−31.267	−11.091	−15.990	1.00	155.37	B	C
  ATOM	6707	O	LYS	H	465	−31.276	−11.407	−17.180	1.00	155.20	B	O
  ATOM	6708	N	GLU	H	472	−30.692	−9.899	−23.132	1.00	145.47	B	N
  ATOM	6709	CA	GLU	H	472	−30.214	−9.535	−24.461	1.00	151.12	B	C
  ATOM	6710	CB	GLU	H	472	−30.931	−8.281	−24.964	1.00	20.00	B	C
  ATOM	6711	CG	GLU	H	472	−32.419	−8.472	−25.209	1.00	20.00	B	C
  ATOM	6712	CD	GLU	H	472	−33.106	−7.192	−25.643	1.00	20.00	B	C
  ATOM	6713	OE1	GLU	H	472	−32.477	−6.117	−25.554	1.00	20.00	B	O
  ATOM	6714	OE2	GLU	H	472	−34.279	−7.260	−26.070	1.00	20.00	B	O
  ATOM	6715	C	GLU	H	472	−28.705	−9.310	−24.462	1.00	153.35	B	C
  ATOM	6716	O	GLU	H	472	−28.208	−8.395	−23.805	1.00	159.41	B	O
  ATOM	6717	N	PRO	H	473	−27.971	−10.164	−25.188	1.00	150.51	B	N
  ATOM	6718	CA	PRO	H	473	−26.535	−10.028	−25.339	1.00	141.97	B	C
  ATOM	6719	CB	PRO	H	473	−26.035	−11.435	−25.011	1.00	20.00	B	C
  ATOM	6720	CG	PRO	H	473	−27.175	−12.350	−25.428	1.00	20.00	B	C
  ATOM	6721	CD	PRO	H	473	−28.424	−11.506	−25.583	1.00	20.00	B	C
  ATOM	6722	C	PRO	H	473	−26.193	−9.688	−26.782	1.00	135.14	B	C
  ATOM	6723	O	PRO	H	473	−26.968	−9.997	−27.687	1.00	144.93	B	O
  ATOM	6724	N	ILE	H	474	−25.024	−9.096	−27.001	1.00	118.07	B	N
  ATOM	6725	CA	ILE	H	474	−24.617	−8.700	−28.344	1.00	105.14	B	C
  ATOM	6726	CB	ILE	H	474	−25.549	−7.614	−28.919	1.00	20.00	B	C
  ATOM	6727	CG1	ILE	H	474	−26.957	−8.174	−29.133	1.00	20.00	B	C
  ATOM	6728	CD1	ILE	H	474	−28.021	−7.109	−29.293	1.00	20.00	B	C
  ATOM	6729	CG2	ILE	H	474	−24.988	−7.064	−30.222	1.00	20.00	B	C
  ATOM	6730	C	ILE	H	474	−23.184	−8.180	−28.352	1.00	104.75	B	C
  ATOM	6731	O	ILE	H	474	−22.938	−7.013	−28.046	1.00	111.83	B	O
  ATOM	6732	N	ILE	H	475	−22.242	−9.045	−28.716	1.00	94.65	B	N
  ATOM	6733	CA	ILE	H	475	−20.826	−8.732	−28.565	1.00	79.88	B	C
  ATOM	6734	CB	ILE	H	475	−20.175	−9.577	−27.453	1.00	20.00	B	C
  ATOM	6735	CG1	ILE	H	475	−20.674	−9.120	−26.079	1.00	20.00	B	C
  ATOM	6736	CD1	ILE	H	475	−20.434	−10.125	−24.972	1.00	20.00	B	C
  ATOM	6737	CG2	ILE	H	475	−18.658	−9.507	−27.545	1.00	20.00	B	C
  ATOM	6738	C	ILE	H	475	−20.051	−8.909	−29.868	1.00	79.52	B	C
  ATOM	6739	O	ILE	H	475	−19.808	−10.032	−30.310	1.00	82.70	B	O
  ATOM	6740	N	ASN	H	476	−19.589	−7.793	−30.425	1.00	69.64	B	N
  ATOM	6741	CA	ASN	H	476	−18.756	−7.812	−31.623	1.00	68.88	B	C
  ATOM	6742	CB	ASN	H	476	−18.880	−6.487	−32.381	1.00	20.00	B	C
  ATOM	6743	CG	ASN	H	476	−20.247	−6.299	−33.011	1.00	20.00	B	C
  ATOM	6744	OD1	ASN	H	476	−20.954	−7.268	−33.288	1.00	20.00	B	O
  ATOM	6745	ND2	ASN	H	476	−20.618	−5.048	−33.257	1.00	20.00	B	N
  ATOM	6746	C	ASN	H	476	−17.290	−8.097	−31.306	1.00	67.13	B	C
  ATOM	6747	O	ASN	H	476	−16.718	−7.507	−30.389	1.00	73.10	B	O
  ATOM	6748	N	PHE	H	477	−16.677	−8.975	−32.096	1.00	64.95	B	N
  ATOM	6749	CA	PHE	H	477	−15.288	−9.380	−31.879	1.00	68.13	B	C
  ATOM	6750	CB	PHE	H	477	−14.918	−10.567	−32.776	1.00	20.00	B	C
  ATOM	6751	CG	PHE	H	477	−15.678	−11.822	−32.466	1.00	20.00	B	C
  ATOM	6752	CD1	PHE	H	477	−15.266	−12.666	−31.448	1.00	20.00	B	C
  ATOM	6753	CE1	PHE	H	477	−15.965	−13.820	−31.162	1.00	20.00	B	C
  ATOM	6754	CZ	PHE	H	477	−17.069	−14.158	−31.915	1.00	20.00	B	C
  ATOM	6755	CE2	PHE	H	477	−17.473	−13.339	−32.949	1.00	20.00	B	C
  ATOM	6756	CD2	PHE	H	477	−16.778	−12.181	−33.222	1.00	20.00	B	C
  ATOM	6757	C	PHE	H	477	−14.307	−8.232	−32.117	1.00	65.57	B	C
  ATOM	6758	O	PHE	H	477	−13.094	−8.412	−31.999	1.00	49.83	B	O
  ATOM	6759	N	TYR	H	478	−14.816	−7.113	−32.617	1.00	51.97	B	N
  ATOM	6760	CA	TYR	H	478	−13.996	−5.920	−32.779	1.00	52.01	B	C
  ATOM	6761	CB	TYR	H	478	−14.573	−5.017	−33.870	1.00	20.00	B	C
  ATOM	6762	CG	TYR	H	478	−14.579	−5.653	−35.247	1.00	20.00	B	C
  ATOM	6763	CD1	TYR	H	478	−13.458	−5.593	−36.069	1.00	20.00	B	C
  ATOM	6764	CE1	TYR	H	478	−13.453	−6.195	−37.316	1.00	20.00	B	C
  ATOM	6765	CZ	TYR	H	478	−14.585	−6.849	−37.766	1.00	20.00	B	C
  ATOM	6766	OH	TYR	H	478	−14.597	−7.434	−39.013	1.00	20.00	B	O
  ATOM	6767	CE2	TYR	H	478	−15.689	−6.967	−36.948	1.00	20.00	B	C
  ATOM	6768	CD2	TYR	H	478	−15.687	−6.360	−35.703	1.00	20.00	B	C
  ATOM	6769	C	TYR	H	478	−13.909	−5.178	−31.454	1.00	66.63	B	C
  ATOM	6770	O	TYR	H	478	−13.401	−4.059	−31.383	1.00	63.45	B	O
  ATOM	6771	N	ASP	H	479	−14.391	−5.828	−30.401	1.00	65.34	B	N
  ATOM	6772	CA	ASP	H	479	−14.256	−5.311	−29.049	1.00	65.32	B	C
  ATOM	6773	CB	ASP	H	479	−15.579	−5.450	−28.296	1.00	20.00	B	C
  ATOM	6774	CG	ASP	H	479	−16.664	−4.552	−28.856	1.00	20.00	B	C
  ATOM	6775	OD1	ASP	H	479	−16.327	−3.593	−29.582	1.00	20.00	B	O
  ATOM	6776	OD2	ASP	H	479	−17.854	−4.799	−28.568	1.00	20.00	B	O
  ATOM	6777	C	ASP	H	479	−13.144	−6.036	−28.300	1.00	64.83	B	C
  ATOM	6778	O	ASP	H	479	−12.738	−5.609	−27.220	1.00	60.42	B	O
  ATOM	6779	N	PRO	H	480	−12.610	−7.108	−28.903	1.00	47.60	B	N
  ATOM	6780	CA	PRO	H	480	−11.568	−7.902	−28.282	1.00	46.52	B	C
  ATOM	6781	CB	PRO	H	480	−11.905	−9.318	−28.742	1.00	20.00	B	C
  ATOM	6782	CG	PRO	H	480	−12.596	−9.131	−30.072	1.00	20.00	B	C
  ATOM	6783	CD	PRO	H	480	−13.021	−7.682	−30.193	1.00	20.00	B	C
  ATOM	6784	C	PRO	H	480	−10.199	−7.497	−28.809	1.00	52.36	B	C
  ATOM	6785	O	PRO	H	480	−9.736	−8.035	−29.815	1.00	64.15	B	O
  ATOM	6786	N	LEU	H	481	−9.618	−6.472	−28.197	1.00	62.90	B	N
  ATOM	6787	CA	LEU	H	481	−8.285	−6.015	−28.562	1.00	54.24	B	C
  ATOM	6788	CB	LEU	H	481	−8.322	−4.544	−28.982	1.00	20.00	B	C
  ATOM	6789	CG	LEU	H	481	−9.202	−4.212	−30.186	1.00	20.00	B	C
  ATOM	6790	CD1	LEU	H	481	−9.255	−2.706	−30.408	1.00	20.00	B	C
  ATOM	6791	CD2	LEU	H	481	−8.698	−4.931	−31.425	1.00	20.00	B	C
  ATOM	6792	C	LEU	H	481	−7.315	−6.203	−27.402	1.00	59.81	B	C
  ATOM	6793	O	LEU	H	481	−7.682	−6.724	−26.348	1.00	64.98	B	O
  ATOM	6794	N	VAL	H	482	−6.058	−5.840	−27.628	1.00	59.66	B	N
  ATOM	6795	CA	VAL	H	482	−5.084	−5.781	−26.549	1.00	49.67	B	C
  ATOM	6796	CB	VAL	H	482	−3.786	−6.531	−26.911	1.00	20.00	B	C
  ATOM	6797	CG1	VAL	H	482	−2.811	−6.492	−25.742	1.00	20.00	B	C
  ATOM	6798	CG2	VAL	H	482	−4.097	−7.973	−27.288	1.00	20.00	B	C
  ATOM	6799	C	VAL	H	482	−4.762	−4.337	−26.191	1.00	53.03	B	C
  ATOM	6800	O	VAL	H	482	−4.706	−3.472	−27.064	1.00	46.27	B	O
  ATOM	6801	N	PHE	H	483	−4.641	−4.070	−24.894	1.00	61.61	B	N
  ATOM	6802	CA	PHE	H	483	−4.311	−2.732	−24.415	1.00	65.03	B	C
  ATOM	6803	CB	PHE	H	483	−5.338	−2.259	−23.391	1.00	20.00	B	C
  ATOM	6804	CG	PHE	H	483	−6.714	−2.064	−23.966	1.00	20.00	B	C
  ATOM	6805	CD1	PHE	H	483	−7.021	−0.928	−24.695	1.00	20.00	B	C
  ATOM	6806	CE1	PHE	H	483	−8.294	−0.739	−25.209	1.00	20.00	B	C
  ATOM	6807	CZ	PHE	H	483	−9.246	−1.731	−25.077	1.00	20.00	B	C
  ATOM	6808	CE2	PHE	H	483	−8.937	−2.888	−24.397	1.00	20.00	B	C
  ATOM	6809	CD2	PHE	H	483	−7.667	−3.065	−23.872	1.00	20.00	B	C
  ATOM	6810	C	PHE	H	483	−2.897	−2.662	−23.852	1.00	71.00	B	C
  ATOM	6811	O	PHE	H	483	−2.704	−2.417	−22.659	1.00	100.44	B	O
  ATOM	6812	N	PRO	H	484	−1.909	−2.972	−24.705	1.00	54.44	B	N
  ATOM	6813	CA	PRO	H	484	−0.512	−3.000	−24.329	1.00	47.46	B	C
  ATOM	6814	CB	PRO	H	484	−0.179	−4.492	−24.438	1.00	20.00	B	C
  ATOM	6815	CG	PRO	H	484	−1.142	−5.021	−25.513	1.00	20.00	B	C
  ATOM	6816	CD	PRO	H	484	−2.157	−3.926	−25.796	1.00	20.00	B	C
  ATOM	6817	C	PRO	H	484	0.323	−2.225	−25.346	1.00	41.56	B	C
  ATOM	6818	O	PRO	H	484	0.278	−2.527	−26.539	1.00	46.53	B	O
  ATOM	6819	N	SER	H	485	1.033	−1.202	−24.883	1.00	46.30	B	N
  ATOM	6820	CA	SER	H	485	1.824	−0.355	−25.768	1.00	49.30	B	C
  ATOM	6821	CB	SER	H	485	3.010	0.252	−25.015	1.00	20.00	B	C
  ATOM	6822	OG	SER	H	485	3.864	−0.754	−24.502	1.00	20.00	B	O
  ATOM	6823	C	SER	H	485	2.307	−1.112	−27.003	1.00	41.24	B	C
  ATOM	6824	O	SER	H	485	1.964	−0.755	−28.131	1.00	46.93	B	O
  ATOM	6825	N	ASP	H	486	3.108	−2.150	−26.785	1.00	49.48	B	N
  ATOM	6826	CA	ASP	H	486	3.700	−2.909	−27.881	1.00	37.44	B	C
  ATOM	6827	CB	ASP	H	486	4.552	−4.054	−27.333	1.00	20.00	B	C
  ATOM	6828	CG	ASP	H	486	5.885	−3.576	−26.790	1.00	20.00	B	C
  ATOM	6829	OD1	ASP	H	486	6.284	−2.437	−27.115	1.00	20.00	B	O
  ATOM	6830	OD2	ASP	H	486	6.556	−4.355	−26.080	1.00	20.00	B	O
  ATOM	6831	C	ASP	H	486	2.628	−3.456	−28.818	1.00	45.66	B	C
  ATOM	6832	O	ASP	H	486	2.683	−3.252	−30.034	1.00	39.86	B	O
  ATOM	6833	N	GLU	H	487	1.627	−4.107	−28.238	1.00	49.20	B	N
  ATOM	6834	CA	GLU	H	487	0.525	−4.652	−29.013	1.00	45.70	B	C
  ATOM	6835	CB	GLU	H	487	−0.444	−5.410	−28.105	1.00	20.00	B	C
  ATOM	6836	CG	GLU	H	487	0.156	−6.664	−27.483	1.00	20.00	B	C
  ATOM	6837	CD	GLU	H	487	−0.814	−7.393	−26.576	1.00	20.00	B	C
  ATOM	6838	OE1	GLU	H	487	−1.852	−6.804	−26.214	1.00	20.00	B	O
  ATOM	6839	OE2	GLU	H	487	−0.514	−8.540	−26.183	1.00	20.00	B	O
  ATOM	6840	C	GLU	H	487	−0.203	−3.556	−29.783	1.00	41.48	B	C
  ATOM	6841	O	GLU	H	487	−0.411	−3.674	−30.989	1.00	48.92	B	O
  ATOM	6842	N	PHE	H	488	−0.486	−2.447	−29.110	1.00	42.16	B	N
  ATOM	6843	CA	PHE	H	488	−1.183	−1.339	−29.747	1.00	39.33	B	C
  ATOM	6844	CB	PHE	H	488	−1.438	−0.219	−28.745	1.00	20.00	B	C
  ATOM	6845	CG	PHE	H	488	−2.369	−0.602	−27.638	1.00	20.00	B	C
  ATOM	6846	CD1	PHE	H	488	−3.739	−0.595	−27.833	1.00	20.00	B	C
  ATOM	6847	CE1	PHE	H	488	−4.602	−0.873	−26.789	1.00	20.00	B	C
  ATOM	6848	CZ	PHE	H	488	−4.095	−1.193	−25.546	1.00	20.00	B	C
  ATOM	6849	CE2	PHE	H	488	−2.731	−1.192	−25.340	1.00	20.00	B	C
  ATOM	6850	CD2	PHE	H	488	−1.876	−0.912	−26.385	1.00	20.00	B	C
  ATOM	6851	C	PHE	H	488	−0.401	−0.804	−30.939	1.00	43.06	B	C
  ATOM	6852	O	PHE	H	488	−0.977	−0.505	−31.984	1.00	61.71	B	O
  ATOM	6853	N	ASP	H	489	0.915	−0.700	−30.782	1.00	41.95	B	N
  ATOM	6854	CA	ASP	H	489	1.766	−0.104	−31.808	1.00	42.75	B	C
  ATOM	6855	CB	ASP	H	489	3.172	0.134	−31.262	1.00	20.00	B	C
  ATOM	6856	CG	ASP	H	489	3.235	1.317	−30.327	1.00	20.00	B	C
  ATOM	6857	OD1	ASP	H	489	2.256	2.089	−30.288	1.00	20.00	B	O
  ATOM	6858	OD2	ASP	H	489	4.252	1.462	−29.617	1.00	20.00	B	O
  ATOM	6859	C	ASP	H	489	1.837	−0.980	−33.054	1.00	45.61	B	C
  ATOM	6860	O	ASP	H	489	2.110	−0.495	−34.154	1.00	54.39	B	O
  ATOM	6861	N	ALA	H	490	1.702	−2.287	−32.853	1.00	42.89	B	N
  ATOM	6862	CA	ALA	H	490	1.705	−3.238	−33.957	1.00	38.40	B	C
  ATOM	6863	CB	ALA	H	490	1.928	−4.653	−33.436	1.00	20.00	B	C
  ATOM	6864	C	ALA	H	490	0.413	−3.160	−34.770	1.00	39.67	B	C
  ATOM	6865	O	ALA	H	490	0.443	−3.194	−35.998	1.00	56.80	B	O
  ATOM	6866	N	SER	H	491	−0.717	−3.050	−34.080	1.00	40.38	B	N
  ATOM	6867	CA	SER	H	491	−2.003	−2.833	−34.737	1.00	41.77	B	C
  ATOM	6868	CB	SER	H	491	−3.155	−2.963	−33.731	1.00	20.00	B	C
  ATOM	6869	OG	SER	H	491	−3.173	−1.878	−32.817	1.00	20.00	B	O
  ATOM	6870	C	SER	H	491	−2.056	−1.474	−35.432	1.00	39.01	B	C
  ATOM	6871	O	SER	H	491	−2.701	−1.325	−36.472	1.00	36.91	B	O
  ATOM	6872	N	ILE	H	492	−1.440	−0.470	−34.812	1.00	38.11	B	N
  ATOM	6873	CA	ILE	H	492	−1.342	0.863	−35.402	1.00	41.21	B	C
  ATOM	6874	CB	ILE	H	492	−0.651	1.856	−34.446	1.00	20.00	B	C
  ATOM	6875	CG1	ILE	H	492	−1.506	2.097	−33.203	1.00	20.00	B	C
  ATOM	6876	CD1	ILE	H	492	−0.883	3.081	−32.232	1.00	20.00	B	C
  ATOM	6877	CG2	ILE	H	492	−0.363	3.173	−35.150	1.00	20.00	B	C
  ATOM	6878	C	ILE	H	492	−0.561	0.826	−36.714	1.00	39.22	B	C
  ATOM	6879	O	ILE	H	492	−0.943	1.466	−37.696	1.00	47.54	B	O
  ATOM	6880	N	SER	H	493	0.535	0.073	−36.718	1.00	41.64	B	N
  ATOM	6881	CA	SER	H	493	1.307	−0.161	−37.933	1.00	35.15	B	C
  ATOM	6882	CB	SER	H	493	2.587	−0.944	−37.618	1.00	20.00	B	C
  ATOM	6883	OG	SER	H	493	2.296	−2.250	−37.147	1.00	20.00	B	O
  ATOM	6884	C	SER	H	493	0.486	−0.880	−39.011	1.00	47.90	B	C
  ATOM	6885	O	SER	H	493	0.565	−0.538	−40.191	1.00	50.94	B	O
  ATOM	6886	N	GLN	H	494	−0.321	−1.855	−38.596	1.00	42.51	B	N
  ATOM	6887	CA	GLN	H	494	−1.175	−2.611	−39.517	1.00	41.96	B	C
  ATOM	6888	CB	GLN	H	494	−1.822	−3.801	−38.795	1.00	20.00	B	C
  ATOM	6889	CG	GLN	H	494	−0.843	−4.905	−38.423	1.00	20.00	B	C
  ATOM	6890	CD	GLN	H	494	−1.489	−6.019	−37.630	1.00	20.00	B	C
  ATOM	6891	OE1	GLN	H	494	−2.536	−5.830	−37.011	1.00	20.00	B	O
  ATOM	6892	NE2	GLN	H	494	−0.893	−7.205	−37.684	1.00	20.00	B	N
  ATOM	6893	C	GLN	H	494	−2.254	−1.721	−40.130	1.00	33.86	B	C
  ATOM	6894	O	GLN	H	494	−2.479	−1.743	−41.340	1.00	54.89	B	O
  ATOM	6895	N	VAL	H	495	−2.973	−1.005	−39.272	1.00	34.99	B	N
  ATOM	6896	CA	VAL	H	495	−3.955	−0.025	−39.718	1.00	38.42	B	C
  ATOM	6897	CB	VAL	H	495	−4.485	0.807	−38.536	1.00	20.00	B	C
  ATOM	6898	CG1	VAL	H	495	−5.501	1.828	−39.016	1.00	20.00	B	C
  ATOM	6899	CG2	VAL	H	495	−5.088	−0.101	−37.479	1.00	20.00	B	C
  ATOM	6900	C	VAL	H	495	−3.344	0.912	−40.751	1.00	42.74	B	C
  ATOM	6901	O	VAL	H	495	−3.876	1.069	−41.850	1.00	44.00	B	O
  ATOM	6902	N	ASN	H	496	−2.171	1.447	−40.434	1.00	42.45	B	N
  ATOM	6903	CA	ASN	H	496	−1.500	2.382	−41.323	1.00	43.01	B	C
  ATOM	6904	CB	ASN	H	496	−0.202	2.880	−40.692	1.00	20.00	B	C
  ATOM	6905	CG	ASN	H	496	−0.446	3.770	−39.497	1.00	20.00	B	C
  ATOM	6906	OD1	ASN	H	496	−1.517	4.360	−39.358	1.00	20.00	B	O
  ATOM	6907	ND2	ASN	H	496	0.537	3.849	−38.608	1.00	20.00	B	N
  ATOM	6908	C	ASN	H	496	−1.227	1.780	−42.695	1.00	43.13	B	C
  ATOM	6909	O	ASN	H	496	−1.502	2.404	−43.720	1.00	54.76	B	O
  ATOM	6910	N	GLU	H	497	−0.737	0.544	−42.708	1.00	42.08	B	N
  ATOM	6911	CA	GLU	H	497	−0.453	−0.150	−43.957	1.00	43.13	B	C
  ATOM	6912	CB	GLU	H	497	0.151	−1.525	−43.678	1.00	20.00	B	C
  ATOM	6913	CG	GLU	H	497	1.651	−1.515	−43.476	1.00	20.00	B	C
  ATOM	6914	CD	GLU	H	497	2.193	−2.884	−43.108	1.00	20.00	B	C
  ATOM	6915	OE1	GLU	H	497	1.402	−3.851	−43.058	1.00	20.00	B	O
  ATOM	6916	OE2	GLU	H	497	3.419	−3.001	−42.899	1.00	20.00	B	O
  ATOM	6917	C	GLU	H	497	−1.724	−0.306	−44.781	1.00	49.77	B	C
  ATOM	6918	O	GLU	H	497	−1.680	−0.352	−46.011	1.00	42.88	B	O
  ATOM	6919	N	LYS	H	498	−2.846	−0.477	−44.088	1.00	41.82	B	N
  ATOM	6920	CA	LYS	H	498	−4.141	−0.621	−44.741	1.00	53.60	B	C
  ATOM	6921	CB	LYS	H	498	−5.174	−1.179	−43.761	1.00	20.00	B	C
  ATOM	6922	CG	LYS	H	498	−4.967	−2.641	−43.403	1.00	20.00	B	C
  ATOM	6923	CD	LYS	H	498	−6.078	−3.148	−42.491	1.00	20.00	B	C
  ATOM	6924	CE	LYS	H	498	−5.896	−4.624	−42.160	1.00	20.00	B	C
  ATOM	6925	NZ	LYS	H	498	−6.862	−5.090	−41.127	1.00	20.00	B	N
  ATOM	6926	C	LYS	H	498	−4.622	0.716	−45.298	1.00	55.29	B	C
  ATOM	6927	O	LYS	H	498	−5.273	0.766	−46.340	1.00	61.06	B	O
  ATOM	6928	N	ILE	H	499	−4.359	1.789	−44.558	1.00	52.22	B	N
  ATOM	6929	CA	ILE	H	499	−4.606	3.140	−45.052	1.00	48.26	B	C
  ATOM	6930	CB	ILE	H	499	−4.213	4.205	−44.012	1.00	20.00	B	C
  ATOM	6931	CG1	ILE	H	499	−5.137	4.139	−42.797	1.00	20.00	B	C
  ATOM	6932	CD1	ILE	H	499	−4.719	5.058	−41.669	1.00	20.00	B	C
  ATOM	6933	CG2	ILE	H	499	−4.246	5.594	−44.631	1.00	20.00	B	C
  ATOM	6934	C	ILE	H	499	−3.809	3.400	−46.323	1.00	49.07	B	C
  ATOM	6935	O	ILE	H	499	−4.273	4.090	−47.232	1.00	58.45	B	O
  ATOM	6936	N	ASN	H	500	−2.600	2.849	−46.371	1.00	51.02	B	N
  ATOM	6937	CA	ASN	H	500	−1.718	3.000	−47.524	1.00	52.06	B	C
  ATOM	6938	CB	ASN	H	500	−0.284	2.663	−47.120	1.00	20.00	B	C
  ATOM	6939	CG	ASN	H	500	0.707	2.898	−48.233	1.00	20.00	B	C
  ATOM	6940	OD1	ASN	H	500	0.607	3.875	−48.973	1.00	20.00	B	O
  ATOM	6941	ND2	ASN	H	500	1.740	2.071	−48.275	1.00	20.00	B	N
  ATOM	6942	C	ASN	H	500	−2.151	2.149	−48.719	1.00	48.31	B	C
  ATOM	6943	O	ASN	H	500	−1.841	2.469	−49.867	1.00	56.89	B	O
  ATOM	6944	N	GLN	H	501	−2.872	1.067	−48.438	1.00	55.87	B	N
  ATOM	6945	CA	GLN	H	501	−3.511	0.269	−49.480	1.00	53.55	B	C
  ATOM	6946	CB	GLN	H	501	−3.879	−1.116	−48.940	1.00	20.00	B	C
  ATOM	6947	CG	GLN	H	501	−2.685	−1.963	−48.513	1.00	20.00	B	C
  ATOM	6948	CD	GLN	H	501	−3.093	−3.333	−47.996	1.00	20.00	B	C
  ATOM	6949	OE1	GLN	H	501	−4.169	−3.495	−47.420	1.00	20.00	B	O
  ATOM	6950	NE2	GLN	H	501	−2.215	−4.317	−48.162	1.00	20.00	B	N
  ATOM	6951	C	GLN	H	501	−4.755	0.964	−50.023	1.00	45.67	B	C
  ATOM	6952	O	GLN	H	501	−4.984	0.994	−51.232	1.00	58.31	B	O
  ATOM	6953	N	SER	H	502	−5.525	1.570	−49.124	1.00	43.44	B	N
  ATOM	6954	CA	SER	H	502	−6.702	2.345	−49.508	1.00	45.40	B	C
  ATOM	6955	CB	SER	H	502	−7.471	2.800	−48.264	1.00	20.00	B	C
  ATOM	6956	OG	SER	H	502	−6.684	3.664	−47.464	1.00	20.00	B	O
  ATOM	6957	C	SER	H	502	−6.319	3.555	−50.358	1.00	55.15	B	C
  ATOM	6958	O	SER	H	502	−7.049	3.943	−51.270	1.00	52.57	B	O
  ATOM	6959	N	LEU	H	503	−5.160	4.135	−50.060	1.00	55.35	B	N
  ATOM	6960	CA	LEU	H	503	−4.662	5.286	−50.805	1.00	52.12	B	C
  ATOM	6961	CB	LEU	H	503	−3.529	5.973	−50.037	1.00	20.00	B	C
  ATOM	6962	CG	LEU	H	503	−3.896	6.598	−48.688	1.00	20.00	B	C
  ATOM	6963	CD1	LEU	H	503	−2.646	7.032	−47.948	1.00	20.00	B	C
  ATOM	6964	CD2	LEU	H	503	−4.847	7.769	−48.868	1.00	20.00	B	C
  ATOM	6965	C	LEU	H	503	−4.187	4.882	−52.197	1.00	55.74	B	C
  ATOM	6966	O	LEU	H	503	−4.339	5.636	−53.159	1.00	57.75	B	O
  ATOM	6967	N	ALA	H	504	−3.608	3.691	−52.295	1.00	57.22	B	N
  ATOM	6968	CA	ALA	H	504	−3.204	3.150	−53.584	1.00	59.12	B	C
  ATOM	6969	CB	ALA	H	504	−2.319	1.930	−53.394	1.00	20.00	B	C
  ATOM	6970	C	ALA	H	504	−4.423	2.802	−54.427	1.00	58.10	B	C
  ATOM	6971	O	ALA	H	504	−4.488	3.145	−55.608	1.00	63.64	B	O
  ATOM	6972	N	PHE	H	505	−5.421	2.194	−53.793	1.00	58.17	B	N
  ATOM	6973	CA	PHE	H	505	−6.683	1.909	−54.464	1.00	56.56	B	C
  ATOM	6974	CB	PHE	H	505	−7.657	1.198	−53.517	1.00	20.00	B	C
  ATOM	6975	CG	PHE	H	505	−7.174	−0.142	−53.045	1.00	20.00	B	C
  ATOM	6976	CD1	PHE	H	505	−7.297	−1.263	−53.851	1.00	20.00	B	C
  ATOM	6977	CE1	PHE	H	505	−6.817	−2.490	−53.432	1.00	20.00	B	C
  ATOM	6978	CZ	PHE	H	505	−6.236	−2.610	−52.183	1.00	20.00	B	C
  ATOM	6979	CE2	PHE	H	505	−6.106	−1.497	−51.373	1.00	20.00	B	C
  ATOM	6980	CD2	PHE	H	505	−6.566	−0.272	−51.809	1.00	20.00	B	C
  ATOM	6981	C	PHE	H	505	−7.307	3.189	−55.020	1.00	60.12	B	C
  ATOM	6982	O	PHE	H	505	−7.761	3.223	−56.166	1.00	65.46	B	O
  ATOM	6983	N	ILE	H	506	−7.214	4.267	−54.247	1.00	56.10	B	N
  ATOM	6984	CA	ILE	H	506	−7.762	5.552	−54.667	1.00	57.32	B	C
  ATOM	6985	CB	ILE	H	506	−7.716	6.599	−53.536	1.00	20.00	B	C
  ATOM	6986	CG1	ILE	H	506	−8.610	6.163	−52.376	1.00	20.00	B	C
  ATOM	6987	CD1	ILE	H	506	−8.728	7.191	−51.274	1.00	20.00	B	C
  ATOM	6988	CG2	ILE	H	506	−8.177	7.956	−54.049	1.00	20.00	B	C
  ATOM	6989	C	ILE	H	506	−7.013	6.084	−55.883	1.00	67.33	B	C
  ATOM	6990	O	ILE	H	506	−7.625	6.563	−56.839	1.00	76.99	B	O
  ATOM	6991	N	ARG	H	507	−5.694	5.913	−55.876	1.00	67.87	B	N
  ATOM	6992	CA	ARG	H	507	−4.858	6.338	−56.993	1.00	62.11	B	C
  ATOM	6993	CB	ARG	H	507	−3.381	6.153	−56.657	1.00	20.00	B	C
  ATOM	6994	CG	ARG	H	507	−2.862	7.130	−55.630	1.00	20.00	B	C
  ATOM	6995	CD	ARG	H	507	−1.380	6.930	−55.386	1.00	20.00	B	C
  ATOM	6996	NE	ARG	H	507	−0.903	7.783	−54.303	1.00	20.00	B	N
  ATOM	6997	CZ	ARG	H	507	0.322	7.729	−53.792	1.00	20.00	B	C
  ATOM	6998	NH1	ARG	H	507	1.215	6.883	−54.288	1.00	20.00	B	N
  ATOM	6999	NH2	ARG	H	507	0.656	8.530	−52.791	1.00	20.00	B	N
  ATOM	7000	C	ARG	H	507	−5.191	5.565	−58.258	1.00	67.30	B	C
  ATOM	7001	O	ARG	H	507	−5.255	6.139	−59.344	1.00	67.02	B	O
  ATOM	7002	N	LYS	H	508	−5.222	4.243	−58.139	1.00	66.83	B	N
  ATOM	7003	CA	LYS	H	508	−5.694	3.391	−59.220	1.00	68.12	B	C
  ATOM	7004	CB	LYS	H	508	−5.743	1.932	−58.763	1.00	20.00	B	C
  ATOM	7005	CG	LYS	H	508	−4.368	1.325	−58.543	1.00	20.00	B	C
  ATOM	7006	CD	LYS	H	508	−4.433	−0.159	−58.230	1.00	20.00	B	C
  ATOM	7007	CE	LYS	H	508	−3.037	−0.710	−57.973	1.00	20.00	B	C
  ATOM	7008	NZ	LYS	H	508	−3.053	−2.129	−57.525	1.00	20.00	B	N
  ATOM	7009	C	LYS	H	508	−7.065	3.839	−59.705	1.00	65.22	B	C
  ATOM	7010	O	LYS	H	508	−7.245	4.154	−60.881	1.00	72.34	B	O
  ATOM	7011	N	SER	H	509	−7.996	3.977	−58.767	1.00	64.87	B	N
  ATOM	7012	CA	SER	H	509	−9.366	4.349	−59.095	1.00	56.47	B	C
  ATOM	7013	CB	SER	H	509	−10.227	4.420	−57.832	1.00	20.00	B	C
  ATOM	7014	OG	SER	H	509	−9.862	5.523	−57.023	1.00	20.00	B	O
  ATOM	7015	C	SER	H	509	−9.418	5.673	−59.851	1.00	56.96	B	C
  ATOM	7016	O	SER	H	509	−10.124	5.796	−60.854	1.00	65.57	B	O
  ATOM	7017	N	ASP	H	510	−8.670	6.661	−59.368	1.00	64.34	B	N
  ATOM	7018	CA	ASP	H	510	−8.624	7.971	−60.009	1.00	64.83	B	C
  ATOM	7019	CB	ASP	H	510	−7.774	8.944	−59.192	1.00	20.00	B	C
  ATOM	7020	CG	ASP	H	510	−8.421	9.315	−57.872	1.00	20.00	B	C
  ATOM	7021	OD1	ASP	H	510	−9.589	8.927	−57.652	1.00	20.00	B	O
  ATOM	7022	OD2	ASP	H	510	−7.729	9.904	−57.015	1.00	20.00	B	O
  ATOM	7023	C	ASP	H	510	−8.087	7.873	−61.431	1.00	62.11	B	C
  ATOM	7024	O	ASP	H	510	−8.711	8.358	−62.373	1.00	67.61	B	O
  ATOM	7025	N	GLU	H	511	−6.939	7.222	−61.584	1.00	64.95	B	N
  ATOM	7026	CA	GLU	H	511	−6.330	7.042	−62.896	1.00	60.64	B	C
  ATOM	7027	CB	GLU	H	511	−5.117	6.109	−62.804	1.00	20.00	B	C
  ATOM	7028	CG	GLU	H	511	−3.959	6.673	−61.982	1.00	20.00	B	C
  ATOM	7029	CD	GLU	H	511	−2.858	5.655	−61.716	1.00	20.00	B	C
  ATOM	7030	OE1	GLU	H	511	−3.140	4.438	−61.756	1.00	20.00	B	O
  ATOM	7031	OE2	GLU	H	511	−1.749	6.076	−61.324	1.00	20.00	B	O
  ATOM	7032	C	GLU	H	511	−7.340	6.528	−63.928	1.00	59.91	B	C
  ATOM	7033	O	GLU	H	511	−7.417	7.043	−65.045	1.00	55.45	B	O
  ATOM	7034	N	LEU	H	512	−8.137	5.537	−63.533	1.00	44.35	B	N
  ATOM	7035	CA	LEU	H	512	−9.117	4.929	−64.432	1.00	49.60	B	C
  ATOM	7036	CB	LEU	H	512	−9.744	3.682	−63.796	1.00	20.00	B	C
  ATOM	7037	CG	LEU	H	512	−8.841	2.462	−63.572	1.00	20.00	B	C
  ATOM	7038	CD1	LEU	H	512	−9.594	1.368	−62.825	1.00	20.00	B	C
  ATOM	7039	CD2	LEU	H	512	−8.295	1.930	−64.892	1.00	20.00	B	C
  ATOM	7040	C	LEU	H	512	−10.208	5.920	−64.821	1.00	58.00	B	C
  ATOM	7041	O	LEU	H	512	−10.524	6.073	−66.000	1.00	55.11	B	O
  ATOM	7042	N	LEU	H	513	−10.814	6.552	−63.820	1.00	57.91	B	N
  ATOM	7043	CA	LEU	H	513	−11.866	7.536	−64.057	1.00	57.49	B	C
  ATOM	7044	CB	LEU	H	513	−12.390	8.097	−62.733	1.00	20.00	B	C
  ATOM	7045	CG	LEU	H	513	−13.077	7.088	−61.815	1.00	20.00	B	C
  ATOM	7046	CD1	LEU	H	513	−13.388	7.705	−60.461	1.00	20.00	B	C
  ATOM	7047	CD2	LEU	H	513	−14.336	6.556	−62.474	1.00	20.00	B	C
  ATOM	7048	C	LEU	H	513	−11.384	8.676	−64.949	1.00	58.78	B	C
  ATOM	7049	O	LEU	H	513	−12.154	9.220	−65.740	1.00	59.88	B	O
  ATOM	7050	N	HIS	H	514	−10.131	9.086	−64.764	1.00	60.07	B	N
  ATOM	7051	CA	HIS	H	514	−9.544	10.151	−65.578	1.00	62.82	B	C
  ATOM	7052	CB	HIS	H	514	−8.240	10.665	−64.951	1.00	20.00	B	C
  ATOM	7053	CG	HIS	H	514	−8.406	11.218	−63.567	1.00	20.00	B	C
  ATOM	7054	ND1	HIS	H	514	−9.083	12.390	−63.308	1.00	20.00	B	N
  ATOM	7055	CE1	HIS	H	514	−9.060	12.634	−62.010	1.00	20.00	B	C
  ATOM	7056	NE2	HIS	H	514	−8.393	11.660	−61.416	1.00	20.00	B	N
  ATOM	7057	CD2	HIS	H	514	−7.960	10.770	−62.368	1.00	20.00	B	C
  ATOM	7058	C	HIS	H	514	−9.305	9.679	−67.014	1.00	65.10	B	C
  ATOM	7059	O	HIS	H	514	−9.352	10.475	−67.953	1.00	66.73	B	O
  ATOM	7060	N	ASN	H	515	−9.179	8.365	−67.187	1.00	63.45	B	N
  ATOM	7061	CA	ASN	H	515	−9.028	7.768	−68.513	1.00	56.53	B	C
  ATOM	7062	CB	ASN	H	515	−8.367	6.392	−68.409	1.00	20.00	B	C
  ATOM	7063	CG	ASN	H	515	−6.901	6.476	−68.035	1.00	20.00	B	C
  ATOM	7064	OD1	ASN	H	515	−6.233	7.470	−68.319	1.00	20.00	B	O
  ATOM	7065	ND2	ASN	H	515	−6.375	5.399	−67.462	1.00	20.00	B	N
  ATOM	7066	C	ASN	H	515	−10.357	7.651	−69.254	1.00	60.06	B	C
  ATOM	7067	O	ASN	H	515	−10.414	7.816	−70.473	1.00	66.48	B	O
  ATOM	7068	N	VAL	H	516	−11.402	7.275	−68.522	1.00	54.29	B	N
  ATOM	7069	CA	VAL	H	516	−12.765	7.256	−69.056	1.00	52.70	B	C
  ATOM	7070	CB	VAL	H	516	−13.775	6.751	−68.001	1.00	20.00	B	C
  ATOM	7071	CG1	VAL	H	516	−15.194	6.825	−68.541	1.00	20.00	B	C
  ATOM	7072	CG2	VAL	H	516	−13.431	5.333	−67.568	1.00	20.00	B	C
  ATOM	7073	C	VAL	H	516	−13.206	8.633	−69.557	1.00	60.10	B	C
  ATOM	7074	O	VAL	H	516	−13.761	8.759	−70.649	1.00	61.55	B	O
  ATOM	7075	N	ASN	H	517	−12.957	9.661	−68.752	1.00	69.10	B	N
  ATOM	7076	CA	ASN	H	517	−13.297	11.030	−69.125	1.00	67.75	B	C
  ATOM	7077	CB	ASN	H	517	−12.850	12.012	−68.038	1.00	20.00	B	C
  ATOM	7078	CG	ASN	H	517	−13.685	11.907	−66.774	1.00	20.00	B	C
  ATOM	7079	OD1	ASN	H	517	−14.835	11.471	−66.813	1.00	20.00	B	O
  ATOM	7080	ND2	ASN	H	517	−13.126	12.355	−65.653	1.00	20.00	B	N
  ATOM	7081	C	ASN	H	517	−12.686	11.424	−70.465	1.00	71.17	B	C
  ATOM	7082	O	ASN	H	517	−13.289	12.169	−71.238	1.00	66.42	B	O
  ATOM	7083	N	ALA	H	518	−11.489	10.912	−70.739	1.00	72.11	B	N
  ATOM	7084	CA	ALA	H	518	−10.794	11.202	−71.989	1.00	74.82	B	C
  ATOM	7085	CB	ALA	H	518	−9.318	10.855	−71.867	1.00	20.00	B	C
  ATOM	7086	C	ALA	H	518	−11.421	10.450	−73.155	1.00	70.11	B	C
  ATOM	7087	O	ALA	H	518	−11.593	11.001	−74.242	1.00	65.18	B	O
  ATOM	7088	N	GLY	H	519	−11.665	9.160	−72.952	1.00	56.07	B	N
  ATOM	7089	CA	GLY	H	519	−12.395	8.360	−73.926	1.00	53.01	B	C
  ATOM	7090	C	GLY	H	519	−13.763	8.941	−74.222	1.00	63.58	B	C
  ATOM	7091	O	GLY	H	519	−14.203	8.960	−75.371	1.00	69.35	B	O
  ATOM	7092	N	LYS	H	520	−14.422	9.444	−73.183	1.00	58.33	B	N
  ATOM	7093	CA	LYS	H	520	−15.716	10.101	−73.333	1.00	53.44	B	C
  ATOM	7094	CB	LYS	H	520	−16.241	10.557	−71.975	1.00	20.00	B	C
  ATOM	7095	CG	LYS	H	520	−16.441	9.429	−70.996	1.00	20.00	B	C
  ATOM	7096	CD	LYS	H	520	−16.739	9.961	−69.616	1.00	20.00	B	C
  ATOM	7097	CE	LYS	H	520	−17.296	8.868	−68.730	1.00	20.00	B	C
  ATOM	7098	NZ	LYS	H	520	−17.807	9.424	−67.452	1.00	20.00	B	N
  ATOM	7099	C	LYS	H	520	−15.623	11.296	−74.268	1.00	58.24	B	C
  ATOM	7100	O	LYS	H	520	−16.579	11.621	−74.972	1.00	48.60	B	O
  ATOM	7101	N	SER	H	521	−14.489	11.986	−74.219	1.00	67.19	B	N
  ATOM	7102	CA	SER	H	521	−14.232	13.101	−75.120	1.00	60.42	B	C
  ATOM	7103	CB	SER	H	521	−12.938	13.821	−74.727	1.00	20.00	B	C
  ATOM	7104	OG	SER	H	521	−11.894	12.898	−74.459	1.00	20.00	B	O
  ATOM	7105	C	SER	H	521	−14.167	12.636	−76.573	1.00	54.19	B	C
  ATOM	7106	O	SER	H	521	−14.886	13.151	−77.430	1.00	65.36	B	O
  ATOM	7107	N	THR	H	522	−13.362	11.609	−76.825	1.00	50.09	B	N
  ATOM	7108	CA	THR	H	522	−13.259	11.025	−78.158	1.00	57.59	B	C
  ATOM	7109	CB	THR	H	522	−12.299	9.817	−78.179	1.00	20.00	B	C
  ATOM	7110	OG1	THR	H	522	−12.774	8.810	−77.278	1.00	20.00	B	O
  ATOM	7111	CG2	THR	H	522	−10.894	10.235	−77.767	1.00	20.00	B	C
  ATOM	7112	C	THR	H	522	−14.625	10.565	−78.646	1.00	59.16	B	C
  ATOM	7113	O	THR	H	522	−15.044	10.893	−79.755	1.00	65.90	B	O
  ATOM	7114	N	THR	H	523	−15.338	9.849	−77.783	1.00	52.59	B	N
  ATOM	7115	CA	THR	H	523	−16.665	9.347	−78.112	1.00	42.19	B	C
  ATOM	7116	CB	THR	H	523	−17.298	8.599	−76.922	1.00	20.00	B	C
  ATOM	7117	OG1	THR	H	523	−17.543	9.516	−75.848	1.00	20.00	B	O
  ATOM	7118	CG2	THR	H	523	−16.373	7.492	−76.435	1.00	20.00	B	C
  ATOM	7119	C	THR	H	523	−17.596	10.466	−78.566	1.00	48.90	B	C
  ATOM	7120	O	THR	H	523	−18.331	10.314	−79.541	1.00	63.19	B	O
  ATOM	7121	N	ASN	H	524	−17.535	11.601	−77.881	1.00	52.51	B	N
  ATOM	7122	CA	ASN	H	524	−18.341	12.752	−78.258	1.00	57.54	B	C
  ATOM	7123	CB	ASN	H	524	−18.235	13.853	−77.202	1.00	20.00	B	C
  ATOM	7124	CG	ASN	H	524	−19.015	13.528	−75.945	1.00	20.00	B	C
  ATOM	7125	OD1	ASN	H	524	−19.910	12.682	−75.959	1.00	20.00	B	O
  ATOM	7126	ND2	ASN	H	524	−18.683	14.203	−74.850	1.00	20.00	B	N
  ATOM	7127	C	ASN	H	524	−17.956	13.287	−79.633	1.00	54.12	B	C
  ATOM	7128	O	ASN	H	524	−18.812	13.463	−80.500	1.00	61.31	B	O
  ATOM	7129	N	SER	H	525	−16.656	13.422	−79.866	1.00	48.97	B	N
  ATOM	7130	CA	SER	H	525	−16.165	13.913	−81.145	1.00	64.81	B	C
  ATOM	7131	CB	SER	H	525	−14.636	13.940	−81.151	1.00	61.22	B	C
  ATOM	7132	OG	SER	H	525	−14.141	14.856	−80.191	1.00	85.90	B	O
  ATOM	7133	C	SER	H	525	−16.689	13.053	−82.292	1.00	69.67	B	C
  ATOM	7134	O	SER	H	525	−17.013	13.563	−83.367	1.00	72.60	B	O
  ATOM	7135	N	LYS	H	526	−16.849	11.760	−82.029	1.00	66.06	B	N
  ATOM	7136	CA	LYS	H	526	−17.335	10.831	−83.043	1.00	63.67	B	C
  ATOM	7137	CB	LYS	H	526	−17.003	9.383	−82.660	1.00	70.55	B	C
  ATOM	7138	CG	LYS	H	526	−15.562	8.963	−82.939	1.00	75.29	B	C
  ATOM	7139	CD	LYS	H	526	−15.205	7.681	−82.194	1.00	85.03	B	C
  ATOM	7140	CE	LYS	H	526	−13.700	7.525	−82.041	1.00	82.65	B	C
  ATOM	7141	NZ	LYS	H	526	−13.347	6.537	−80.984	1.00	73.89	B	N
  ATOM	7142	C	LYS	H	526	−18.838	10.987	−83.239	1.00	55.36	B	C
  ATOM	7143	O	LYS	H	526	−19.333	10.950	−84.365	1.00	70.69	B	O
  ATOM	7144	N	ILE	H	527	−19.560	11.149	−82.135	1.00	57.52	B	N
  ATOM	7145	CA	ILE	H	527	−20.995	11.389	−82.189	1.00	58.48	B	C
  ATOM	7146	CB	ILE	H	527	−21.569	11.642	−80.787	1.00	57.00	B	C
  ATOM	7147	CG1	ILE	H	527	−21.356	10.420	−79.891	1.00	49.07	B	C
  ATOM	7148	CD1	ILE	H	527	−21.790	9.118	−80.517	1.00	46.18	B	C
  ATOM	7149	CG2	ILE	H	527	−23.035	12.029	−80.872	1.00	52.63	B	C
  ATOM	7150	C	ILE	H	527	−21.317	12.586	−83.075	1.00	65.20	B	C
  ATOM	7151	O	ILE	H	527	−22.228	12.532	−83.900	1.00	66.48	B	O
  ATOM	7152	N	TYR	H	528	−20.590	13.681	−82.870	1.00	69.78	B	N
  ATOM	7153	CA	TYR	H	528	−20.780	14.884	−83.673	1.00	72.52	B	C
  ATOM	7154	CB	TYR	H	528	−19.738	15.948	−83.316	1.00	73.16	B	C
  ATOM	7155	CG	TYR	H	528	−19.707	16.343	−81.856	1.00	76.94	B	C
  ATOM	7156	CD1	TYR	H	528	−18.615	17.018	−81.327	1.00	70.95	B	C
  ATOM	7157	CE1	TYR	H	528	−18.584	17.406	−80.000	1.00	67.73	B	C
  ATOM	7158	CZ	TYR	H	528	−19.653	17.114	−79.180	1.00	71.89	B	C
  ATOM	7159	OH	TYR	H	528	−19.626	17.490	−77.856	1.00	75.44	B	O
  ATOM	7160	CE2	TYR	H	528	−20.759	16.464	−79.687	1.00	77.03	B	C
  ATOM	7161	CD2	TYR	H	528	−20.782	16.084	−81.018	1.00	77.84	B	C
  ATOM	7162	C	TYR	H	528	−20.678	14.551	−85.157	1.00	71.63	B	C
  ATOM	7163	O	TYR	H	528	−21.609	14.797	−85.925	1.00	84.20	B	O
  ATOM	7164	N	HIS	H	529	−19.526	14.025	−85.559	1.00	67.69	B	N
  ATOM	7165	CA	HIS	H	529	−19.265	13.733	−86.962	1.00	60.28	B	C
  ATOM	7166	CB	HIS	H	529	−17.883	13.102	−87.131	1.00	67.84	B	C
  ATOM	7167	CG	HIS	H	529	−16.752	14.042	−86.853	1.00	88.54	B	C
  ATOM	7168	ND1	HIS	H	529	−15.514	13.914	−87.444	1.00	93.34	B	N
  ATOM	7169	CE1	HIS	H	529	−14.718	14.874	−87.007	1.00	86.23	B	C
  ATOM	7170	NE2	HIS	H	529	−15.394	15.614	−86.145	1.00	91.95	B	N
  ATOM	7171	CD2	HIS	H	529	−16.667	15.110	−86.026	1.00	93.77	B	C
  ATOM	7172	C	HIS	H	529	−20.333	12.817	−87.546	1.00	63.30	B	C
  ATOM	7173	O	HIS	H	529	−20.803	13.034	−88.663	1.00	61.02	B	O
  ATOM	7174	N	ILE	H	530	−20.710	11.791	−86.791	1.00	59.79	B	N
  ATOM	7175	CA	ILE	H	530	−21.800	10.915	−87.201	1.00	45.70	B	C
  ATOM	7176	CB	ILE	H	530	−22.019	9.780	−86.190	1.00	40.57	B	C
  ATOM	7177	CG1	ILE	H	530	−20.879	8.765	−86.292	1.00	42.86	B	C
  ATOM	7178	CD1	ILE	H	530	−20.826	7.775	−85.154	1.00	51.01	B	C
  ATOM	7179	CG2	ILE	H	530	−23.360	9.108	−86.437	1.00	35.31	B	C
  ATOM	7180	C	ILE	H	530	−23.085	11.717	−87.331	1.00	57.52	B	C
  ATOM	7181	O	ILE	H	530	−23.779	11.645	−88.345	1.00	71.18	B	O
  ATOM	7182	N	GLU	H	531	−23.322	12.569	−86.341	1.00	67.55	B	N
  ATOM	7183	CA	GLU	H	531	−24.479	13.449	−86.325	1.00	69.79	B	C
  ATOM	7184	CB	GLU	H	531	−24.440	14.327	−85.074	1.00	84.02	B	C
  ATOM	7185	CG	GLU	H	531	−25.803	14.718	−84.541	1.00	104.22	B	C
  ATOM	7186	CD	GLU	H	531	−25.706	15.531	−83.270	1.00	116.08	B	C
  ATOM	7187	OE1	GLU	H	531	−25.017	15.079	−82.331	1.00	118.71	B	O
  ATOM	7188	OE2	GLU	H	531	−26.222	16.669	−83.251	1.00	119.69	B	O
  ATOM	7189	C	GLU	H	531	−24.506	14.328	−87.569	1.00	64.87	B	C
  ATOM	7190	O	GLU	H	531	−25.517	14.404	−88.269	1.00	55.58	B	O
  ATOM	7191	N	ASN	H	532	−23.394	15.011	−87.821	1.00	65.70	B	N
  ATOM	7192	CA	ASN	H	532	−23.273	15.890	−88.979	1.00	64.16	B	C
  ATOM	7193	CB	ASN	H	532	−21.931	16.625	−88.953	1.00	60.58	B	C
  ATOM	7194	CG	ASN	H	532	−21.793	17.621	−90.085	1.00	67.75	B	C
  ATOM	7195	OD1	ASN	H	532	−22.591	18.550	−90.206	1.00	53.59	B	O
  ATOM	7196	ND2	ASN	H	532	−20.822	17.392	−90.961	1.00	61.81	B	N
  ATOM	7197	C	ASN	H	532	−23.418	15.119	−90.284	1.00	72.17	B	C
  ATOM	7198	O	ASN	H	532	−24.041	15.593	−91.233	1.00	85.75	B	O
  ATOM	7199	N	GLU	H	533	−22.870	13.909	−90.300	1.00	79.68	B	N
  ATOM	7200	CA	GLU	H	533	−22.922	13.044	−91.468	1.00	71.96	B	C
  ATOM	7201	CB	GLU	H	533	−22.010	11.837	−91.264	1.00	67.87	B	C
  ATOM	7202	CG	GLU	H	533	−21.638	11.131	−92.547	1.00	81.94	B	C
  ATOM	7203	CD	GLU	H	533	−20.906	12.037	−93.515	1.00	92.79	B	C
  ATOM	7204	OE1	GLU	H	533	−19.930	12.692	−93.094	1.00	95.90	B	O
  ATOM	7205	OE2	GLU	H	533	−21.247	12.025	−94.716	1.00	93.14	B	O
  ATOM	7206	C	GLU	H	533	−24.342	12.570	−91.747	1.00	68.54	B	C
  ATOM	7207	O	GLU	H	533	−24.667	12.175	−92.866	1.00	79.29	B	O
  ATOM	7208	N	ILE	H	534	−25.137	12.470	−90.688	1.00	69.50	B	N
  ATOM	7209	CA	ILE	H	534	−26.529	12.076	−90.817	1.00	72.55	B	C
  ATOM	7210	CB	ILE	H	534	−27.056	11.467	−89.514	1.00	79.55	B	C
  ATOM	7211	CG1	ILE	H	534	−26.263	10.209	−89.164	1.00	80.41	B	C
  ATOM	7212	CD1	ILE	H	534	−25.562	9.592	−90.348	1.00	89.38	B	C
  ATOM	7213	CG2	ILE	H	534	−28.526	11.138	−89.645	1.00	78.63	B	C
  ATOM	7214	C	ILE	H	534	−27.389	13.273	−91.189	1.00	74.92	B	C
  ATOM	7215	O	ILE	H	534	−28.479	13.120	−91.740	1.00	81.01	B	O
  ATOM	7216	N	ALA	H	535	−26.880	14.465	−90.903	1.00	79.52	B	N
  ATOM	7217	CA	ALA	H	535	−27.559	15.690	−91.290	1.00	82.64	B	C
  ATOM	7218	CB	ALA	H	535	−27.016	16.867	−90.498	1.00	75.39	B	C
  ATOM	7219	C	ALA	H	535	−27.440	15.939	−92.795	1.00	81.39	B	C
  ATOM	7220	O	ALA	H	535	−28.408	16.341	−93.443	1.00	85.54	B	O
  ATOM	7221	N	ARG	H	536	−26.274	15.630	−93.358	1.00	78.41	B	N
  ATOM	7222	CA	ARG	H	536	−26.044	15.812	−94.791	1.00	83.27	B	C
  ATOM	7223	CB	ARG	H	536	−24.545	15.814	−95.106	1.00	84.58	B	C
  ATOM	7224	CG	ARG	H	536	−23.776	16.993	−94.527	1.00	103.24	B	C
  ATOM	7225	CD	ARG	H	536	−22.638	17.422	−95.449	1.00	114.72	B	C
  ATOM	7226	NE	ARG	H	536	−21.692	16.343	−95.722	1.00	117.80	B	N
  ATOM	7227	CZ	ARG	H	536	−20.692	16.430	−96.594	1.00	116.66	B	C
  ATOM	7228	NH1	ARG	H	536	−20.522	17.538	−97.303	1.00	114.57	B	N
  ATOM	7229	NH2	ARG	H	536	−19.885	15.396	−96.786	1.00	116.38	B	N
  ATOM	7230	C	ARG	H	536	−26.744	14.727	−95.606	1.00	82.20	B	C
  ATOM	7231	O	ARG	H	536	−27.369	15.011	−96.627	1.00	86.28	B	O
  ATOM	7232	N	ILE	H	537	−26.598	13.479	−95.172	1.00	77.08	B	N
  ATOM	7233	CA	ILE	H	537	−27.315	12.371	−95.782	1.00	66.79	B	C
  ATOM	7234	CB	ILE	H	537	−26.955	11.038	−95.113	1.00	64.76	B	C
  ATOM	7235	CG1	ILE	H	537	−25.523	10.627	−95.476	1.00	66.92	B	C
  ATOM	7236	CD1	ILE	H	537	−24.906	9.625	−94.519	1.00	70.83	B	C
  ATOM	7237	CG2	ILE	H	537	−27.960	9.964	−95.497	1.00	51.02	B	C
  ATOM	7238	C	ILE	H	537	−28.817	12.585	−95.674	1.00	74.94	B	C
  ATOM	7239	O	ILE	H	537	−29.587	12.070	−96.482	1.00	97.16	B	O
  ATOM	7240	N	LYS	H	538	−29.232	13.337	−94.661	1.00	75.09	B	N
  ATOM	7241	CA	LYS	H	538	−30.640	13.666	−94.485	1.00	90.28	B	C
  ATOM	7242	CB	LYS	H	538	−30.958	13.868	−93.003	1.00	93.73	B	C
  ATOM	7243	CG	LYS	H	538	−32.344	13.390	−92.575	1.00	96.60	B	C
  ATOM	7244	CD	LYS	H	538	−32.640	13.787	−91.126	1.00	95.37	B	C
  ATOM	7245	CE	LYS	H	538	−34.127	13.714	−90.798	1.00	100.63	B	C
  ATOM	7246	NZ	LYS	H	538	−34.398	14.067	−89.375	1.00	99.58	B	N
  ATOM	7247	C	LYS	H	538	−31.022	14.911	−95.284	1.00	102.20	B	C
  ATOM	7248	O	LYS	H	538	−32.166	15.360	−95.235	1.00	112.11	B	O
  ATOM	7249	N	LYS	H	539	−30.069	15.444	−96.043	1.00	105.15	B	N
  ATOM	7250	CA	LYS	H	539	−30.317	16.603	−96.899	1.00	105.65	B	C
  ATOM	7251	CB	LYS	H	539	−29.144	17.589	−96.823	1.00	110.12	B	C
  ATOM	7252	CG	LYS	H	539	−29.408	18.944	−97.481	1.00	113.31	B	C
  ATOM	7253	CD	LYS	H	539	−28.182	19.854	−97.435	1.00	114.26	B	C
  ATOM	7254	CE	LYS	H	539	−28.426	21.145	−98.205	1.00	118.39	B	C
  ATOM	7255	NZ	LYS	H	539	−27.168	21.897	−98.470	1.00	121.77	B	N
  ATOM	7256	C	LYS	H	539	−30.572	16.187	−98.347	1.00	108.88	B	C
  ATOM	7257	O	LYS	H	539	−30.886	17.021	−99.195	1.00	110.77	B	O
  ATOM	7258	N	LEU	H	540	−30.515	14.884	−98.605	1.00	111.50	B	N
  ATOM	7259	CA	LEU	H	540	−30.796	14.356	−99.935	1.00	110.31	B	C
  ATOM	7260	CB	LEU	H	540	−29.690	13.389	−100.368	1.00	101.19	B	C
  ATOM	7261	CG	LEU	H	540	−28.270	13.889	−100.078	1.00	94.26	B	C
  ATOM	7262	CD1	LEU	H	540	−27.249	12.769	−100.179	1.00	86.40	B	C
  ATOM	7263	CD2	LEU	H	540	−27.896	15.059	−100.984	1.00	84.54	B	C
  ATOM	7264	C	LEU	H	540	−32.157	13.675	−99.961	1.00	118.37	B	C
  ATOM	7265	O	LEU	H	540	−32.531	13.039	−100.945	1.00	116.71	B	O
  ATOM	7266	N	ILE	H	541	−32.923	13.883	−98.896	1.00	130.80	B	N
  ATOM	7267	CA	ILE	H	541	−34.267	13.339	−98.801	1.00	140.48	B	C
  ATOM	7268	CB	ILE	H	541	−34.250	11.862	−98.372	1.00	138.99	B	C
  ATOM	7269	CG1	ILE	H	541	−33.319	11.059	−99.282	1.00	133.30	B	C
  ATOM	7270	CD1	ILE	H	541	−33.895	10.789	−100.656	1.00	136.26	B	C
  ATOM	7271	CG2	ILE	H	541	−35.653	11.281	−98.432	1.00	136.12	B	C
  ATOM	7272	C	ILE	H	541	−35.146	14.139	−97.839	1.00	144.97	B	C
  ATOM	7273	O	ILE	H	541	−36.372	14.063	−97.905	1.00	145.83	B	O
  ATOM	7274	N	GLY	H	542	−34.523	14.940	−96.979	1.00	148.77	B	N
  ATOM	7275	CA	GLY	H	542	−35.267	15.725	−95.991	1.00	153.58	B	C
  ATOM	7276	C	GLY	H	542	−35.358	17.210	−96.308	1.00	160.45	B	C
  ATOM	7277	O	GLY	H	542	−35.594	17.599	−97.454	1.00	163.41	B	O
  ATOM	7278	N	GLU	H	543	−35.275	18.034	−95.267	1.00	163.83	B	N
  ATOM	7279	CA	GLU	H	543	−35.152	19.480	−95.430	1.00	165.52	B	C
  ATOM	7280	CB	GLU	H	543	−35.727	20.205	−94.211	1.00	158.94	B	C
  ATOM	7285	C	GLU	H	543	−33.698	19.890	−95.644	1.00	168.27	B	C
  ATOM	7286	O	GLU	H	543	−32.778	19.116	−95.373	1.00	167.37	B	O
  ATOM	7287	N	GLN	I	26	21.181	−26.937	−9.836	1.00	23.62	C	N
  ATOM	7288	CA	GLN	I	26	21.159	−25.618	−10.530	1.00	23.82	C	C
  ATOM	7289	CB	GLN	I	26	21.607	−24.503	−9.580	1.00	23.94	C	C
  ATOM	7290	CG	GLN	I	26	20.888	−24.492	−8.237	1.00	28.83	C	C
  ATOM	7291	CD	GLN	I	26	21.323	−25.626	−7.329	1.00	36.36	C	C
  ATOM	7292	OE1	GLN	I	26	20.813	−26.740	−7.428	1.00	39.09	C	O
  ATOM	7293	NE2	GLN	I	26	22.207	−25.325	−6.384	1.00	37.86	C	N
  ATOM	7294	C	GLN	I	26	22.043	−25.641	−11.774	1.00	23.09	C	C
  ATOM	7295	O	GLN	I	26	22.946	−26.471	−11.888	1.00	24.21	C	O
  ATOM	7296	N	ASN	I	27	21.670	−24.835	−12.765	1.00	20.98	C	N
  ATOM	7297	CA	ASN	I	27	22.435	−24.709	−14.004	1.00	19.70	C	C
  ATOM	7298	CB	ASN	I	27	22.165	−25.904	−14.928	1.00	20.41	C	C
  ATOM	7299	CG	ASN	I	27	22.952	−25.833	−16.231	1.00	23.56	C	C
  ATOM	7300	OD1	ASN	I	27	24.156	−25.579	−16.199	1.00	24.42	C	O
  ATOM	7301	ND2	ASN	I	27	22.227	−25.693	−17.339	1.00	27.70	C	N
  ATOM	7302	C	ASN	I	27	22.086	−23.414	−14.727	1.00	18.42	C	C
  ATOM	7303	O	ASN	I	27	21.539	−23.447	−15.830	1.00	18.47	C	O
  ATOM	7304	N	ILE	I	28	22.230	−22.288	−14.033	1.00	16.54	C	N
  ATOM	7305	CA	ILE	I	28	21.853	−21.004	−14.611	1.00	14.59	C	C
  ATOM	7306	CB	ILE	I	28	21.526	−19.932	−13.546	1.00	14.01	C	C
  ATOM	7307	CG1	ILE	I	28	22.461	−20.055	−12.343	1.00	15.60	C	C
  ATOM	7308	CD1	ILE	I	28	23.710	−19.205	−12.454	1.00	16.26	C	C
  ATOM	7309	CG2	ILE	I	28	20.065	−20.023	−13.122	1.00	12.57	C	C
  ATOM	7310	C	ILE	I	28	22.915	−20.484	−15.561	1.00	13.86	C	C
  ATOM	7311	O	ILE	I	28	24.111	−20.702	−15.363	1.00	13.70	C	O
  ATOM	7312	N	THR	I	29	22.442	−20.013	−16.703	1.00	13.23	C	N
  ATOM	7313	CA	THR	I	29	23.301	−19.589	−17.786	1.00	12.65	C	C
  ATOM	7314	CB	THR	I	29	23.241	−20.586	−18.948	1.00	12.69	C	C
  ATOM	7315	OG1	THR	I	29	22.805	−21.861	−18.463	1.00	12.62	C	O
  ATOM	7316	CG2	THR	I	29	24.603	−20.727	−19.608	1.00	12.92	C	C
  ATOM	7317	C	THR	I	29	22.740	−18.277	−18.281	1.00	12.47	C	C
  ATOM	7318	O	THR	I	29	21.531	−18.051	−18.220	1.00	12.53	C	O
  ATOM	7319	N	GLU	I	30	23.596	−17.467	−18.884	1.00	11.98	C	N
  ATOM	7320	CA	GLU	I	30	23.135	−16.364	−19.702	1.00	11.68	C	C
  ATOM	7321	CB	GLU	I	30	23.508	−15.035	−19.049	1.00	11.98	C	C
  ATOM	7322	CG	GLU	I	30	22.537	−13.901	−19.321	1.00	13.38	C	C
  ATOM	7323	CD	GLU	I	30	22.687	−12.767	−18.325	1.00	16.03	C	C
  ATOM	7324	OE1	GLU	I	30	23.820	−12.269	−18.155	1.00	16.65	C	O
  ATOM	7325	OE2	GLU	I	30	21.684	−12.412	−17.673	1.00	17.06	C	O
  ATOM	7326	C	GLU	I	30	23.814	−16.480	−21.047	1.00	11.39	C	C
  ATOM	7327	O	GLU	I	30	25.000	−16.799	−21.124	1.00	11.50	C	O
  ATOM	7328	N	GLU	I	31	23.036	−16.344	−22.111	1.00	11.11	C	N
  ATOM	7329	CA	GLU	I	31	23.626	−16.233	−23.427	1.00	11.06	C	C
  ATOM	7330	CB	GLU	I	31	23.376	−17.494	−24.251	1.00	11.48	C	C
  ATOM	7331	CG	GLU	I	31	22.395	−17.322	−25.391	1.00	13.90	C	C
  ATOM	7332	CD	GLU	I	31	22.329	−18.546	−26.280	1.00	17.27	C	C
  ATOM	7333	OE1	GLU	I	31	22.658	−18.428	−27.478	1.00	17.55	C	O
  ATOM	7334	OE2	GLU	I	31	21.999	−19.638	−25.769	1.00	18.73	C	O
  ATOM	7335	C	GLU	I	31	23.177	−14.989	−24.167	1.00	10.47	C	C
  ATOM	7336	O	GLU	I	31	22.010	−14.597	−24.118	1.00	10.12	C	O
  ATOM	7337	N	PHE	I	32	24.139	−14.352	−24.816	1.00	10.15	C	N
  ATOM	7338	CA	PHE	I	32	23.986	−12.994	−25.289	1.00	9.62	C	C
  ATOM	7339	CB	PHE	I	32	25.267	−12.204	−25.017	1.00	9.42	C	C
  ATOM	7340	CG	PHE	I	32	25.384	−10.939	−25.822	1.00	9.27	C	C
  ATOM	7341	CD1	PHE	I	32	24.529	−9.871	−25.585	1.00	9.37	C	C
  ATOM	7342	CE1	PHE	I	32	24.614	−8.713	−26.339	1.00	9.52	C	C
  ATOM	7343	CZ	PHE	I	32	25.594	−8.593	−27.306	1.00	9.82	C	C
  ATOM	7344	CE2	PHE	I	32	26.458	−9.651	−27.548	1.00	10.13	C	C
  ATOM	7345	CD2	PHE	I	32	26.372	−10.802	−26.786	1.00	10.06	C	C
  ATOM	7346	C	PHE	I	32	23.715	−13.038	−26.782	1.00	9.64	C	C
  ATOM	7347	O	PHE	I	32	24.336	−13.811	−27.512	1.00	9.84	C	O
  ATOM	7348	N	TYR	I	33	22.764	−12.229	−27.228	1.00	9.59	C	N
  ATOM	7349	CA	TYR	I	33	22.384	−12.221	−28.629	1.00	9.67	C	C
  ATOM	7350	CB	TYR	I	33	20.874	−12.414	−28.771	1.00	9.52	C	C
  ATOM	7351	CG	TYR	I	33	20.408	−13.802	−28.397	1.00	10.94	C	C
  ATOM	7352	CD1	TYR	I	33	19.978	−14.084	−27.107	1.00	12.23	C	C
  ATOM	7353	CE1	TYR	I	33	19.587	−15.359	−26.750	1.00	12.93	C	C
  ATOM	7354	CZ	TYR	I	33	19.675	−16.381	−27.670	1.00	13.47	C	C
  ATOM	7355	OH	TYR	I	33	19.297	−17.656	−27.315	1.00	14.54	C	O
  ATOM	7356	CE2	TYR	I	33	20.151	−16.137	−28.941	1.00	13.56	C	C
  ATOM	7357	CD2	TYR	I	33	20.538	−14.858	−29.288	1.00	12.96	C	C
  ATOM	7358	C	TYR	I	33	22.832	−10.933	−29.306	1.00	9.94	C	C
  ATOM	7359	O	TYR	I	33	22.138	−9.917	−29.257	1.00	10.16	C	O
  ATOM	7360	N	GLN	I	34	24.036	−10.964	−29.865	1.00	10.06	C	N
  ATOM	7361	CA	GLN	I	34	24.713	−9.751	−30.294	1.00	10.01	C	C
  ATOM	7362	CB	GLN	I	34	26.105	−10.085	−30.819	1.00	10.22	C	C
  ATOM	7363	CG	GLN	I	34	26.862	−8.884	−31.336	1.00	11.12	C	C
  ATOM	7364	CD	GLN	I	34	28.323	−9.187	−31.577	1.00	13.13	C	C
  ATOM	7365	OE1	GLN	I	34	28.674	−9.887	−32.528	1.00	14.24	C	O
  ATOM	7366	NE2	GLN	I	34	29.183	−8.693	−30.693	1.00	13.79	C	N
  ATOM	7367	C	GLN	I	34	23.914	−9.028	−31.370	1.00	9.94	C	C
  ATOM	7368	O	GLN	I	34	24.051	−7.818	−31.550	1.00	10.08	C	O
  ATOM	7369	N	SER	I	35	23.079	−9.781	−32.081	1.00	9.87	C	N
  ATOM	7370	CA	SER	I	35	22.336	−9.255	−33.225	1.00	9.91	C	C
  ATOM	7371	CB	SER	I	35	21.995	−10.382	−34.206	1.00	10.03	C	C
  ATOM	7372	OG	SER	I	35	21.241	−11.403	−33.574	1.00	10.81	C	O
  ATOM	7373	C	SER	I	35	21.059	−8.555	−32.775	1.00	9.56	C	C
  ATOM	7374	O	SER	I	35	20.248	−8.124	−33.595	1.00	9.59	C	O
  ATOM	7375	N	THR	I	36	20.823	−8.581	−31.472	1.00	9.21	C	N
  ATOM	7376	CA	THR	I	36	19.592	−8.066	−30.903	1.00	9.06	C	C
  ATOM	7377	CB	THR	I	36	18.648	−9.214	−30.517	1.00	9.49	C	C
  ATOM	7378	OG1	THR	I	36	18.292	−9.956	−31.691	1.00	10.82	C	O
  ATOM	7379	CG2	THR	I	36	17.392	−8.673	−29.860	1.00	9.45	C	C
  ATOM	7380	C	THR	I	36	19.966	−7.274	−29.661	1.00	8.77	C	C
  ATOM	7381	O	THR	I	36	19.112	−6.915	−28.848	1.00	8.60	C	O
  ATOM	7382	N	CYS	I	37	21.266	−7.035	−29.515	1.00	8.69	C	N
  ATOM	7383	CA	CYS	I	37	21.818	−6.428	−28.314	1.00	8.69	C	C
  ATOM	7384	CB	CYS	I	37	21.917	−4.911	−28.490	1.00	8.81	C	C
  ATOM	7385	SG	CYS	I	37	23.280	−4.138	−27.602	1.00	10.80	C	S
  ATOM	7386	C	CYS	I	37	20.954	−6.758	−27.107	1.00	8.27	C	C
  ATOM	7387	O	CYS	I	37	20.341	−5.872	−26.513	1.00	8.27	C	O
  ATOM	7388	N	SER	I	38	20.825	−8.045	−26.808	1.00	7.92	C	N
  ATOM	7389	CA	SER	I	38	19.990	−8.476	−25.699	1.00	7.51	C	C
  ATOM	7390	CB	SER	I	38	18.537	−8.626	−26.150	1.00	7.63	C	C
  ATOM	7391	OG	SER	I	38	18.429	−9.583	−27.190	1.00	8.54	C	O
  ATOM	7392	C	SER	I	38	20.496	−9.784	−25.110	1.00	7.02	C	C
  ATOM	7393	O	SER	I	38	21.196	−10.546	−25.776	1.00	6.83	C	O
  ATOM	7394	N	ALA	I	39	20.214	−9.995	−23.830	1.00	6.64	C	N
  ATOM	7395	CA	ALA	I	39	20.727	−11.159	−23.127	1.00	6.58	C	C
  ATOM	7396	CB	ALA	I	39	21.834	−10.761	−22.174	1.00	6.67	C	C
  ATOM	7397	C	ALA	I	39	19.615	−11.885	−22.388	1.00	6.93	C	C
  ATOM	7398	O	ALA	I	39	18.683	−11.263	−21.878	1.00	7.38	C	O
  ATOM	7399	N	VAL	I	40	19.675	−13.211	−22.415	1.00	6.87	C	N
  ATOM	7400	CA	VAL	I	40	18.707	−14.034	−21.706	1.00	6.55	C	C
  ATOM	7401	CB	VAL	I	40	17.905	−14.928	−22.668	1.00	6.22	C	C
  ATOM	7402	CG1	VAL	I	40	17.196	−16.031	−21.899	1.00	6.52	C	C
  ATOM	7403	CG2	VAL	I	40	16.905	−14.098	−23.456	1.00	6.62	C	C
  ATOM	7404	C	VAL	I	40	19.394	−14.909	−20.670	1.00	6.73	C	C
  ATOM	7405	O	VAL	I	40	20.351	−15.620	−20.977	1.00	6.83	C	O
  ATOM	7406	N	SER	I	41	18.916	−14.822	−19.434	1.00	6.86	C	N
  ATOM	7407	CA	SER	I	41	19.298	−15.760	−18.388	1.00	6.75	C	C
  ATOM	7408	CB	SER	I	41	19.221	−15.082	−17.022	1.00	7.06	C	C
  ATOM	7409	OG	SER	I	41	18.745	−13.752	−17.148	1.00	7.50	C	O
  ATOM	7410	C	SER	I	41	18.399	−16.988	−18.409	1.00	6.56	C	C
  ATOM	7411	O	SER	I	41	17.174	−16.873	−18.403	1.00	6.08	C	O
  ATOM	7412	N	LYS	I	42	19.019	−18.163	−18.409	1.00	7.02	C	N
  ATOM	7413	CA	LYS	I	42	18.311	−19.409	−18.665	1.00	7.83	C	C
  ATOM	7414	CB	LYS	I	42	18.835	−20.066	−19.943	1.00	8.15	C	C
  ATOM	7415	CG	LYS	I	42	18.753	−19.192	−21.182	1.00	9.75	C	C
  ATOM	7416	CD	LYS	I	42	19.416	−19.872	−22.369	1.00	12.62	C	C
  ATOM	7417	CE	LYS	I	42	19.087	−19.162	−23.671	1.00	14.04	C	C
  ATOM	7418	NZ	LYS	I	42	19.298	−20.046	−24.851	1.00	14.96	C	N
  ATOM	7419	C	LYS	I	42	18.489	−20.367	−17.495	1.00	7.80	C	C
  ATOM	7420	O	LYS	I	42	19.512	−20.336	−16.810	1.00	8.15	C	O
  ATOM	7421	N	GLY	I	43	17.581	−21.330	−17.389	1.00	7.59	C	N
  ATOM	7422	CA	GLY	I	43	17.783	−22.472	−16.508	1.00	7.35	C	C
  ATOM	7423	C	GLY	I	43	17.031	−22.326	−15.202	1.00	7.10	C	C
  ATOM	7424	O	GLY	I	43	17.428	−22.883	−14.179	1.00	7.13	C	O
  ATOM	7425	N	TYR	I	44	15.907	−21.621	−15.253	1.00	7.01	C	N
  ATOM	7426	CA	TYR	I	44	15.095	−21.391	−14.066	1.00	6.89	C	C
  ATOM	7427	CB	TYR	I	44	14.678	−19.924	−13.982	1.00	6.88	C	C
  ATOM	7428	CG	TYR	I	44	15.828	−18.979	−13.738	1.00	6.41	C	C
  ATOM	7429	CD1	TYR	I	44	16.374	−18.238	−14.776	1.00	6.62	C	C
  ATOM	7430	CE1	TYR	I	44	17.430	−17.376	−14.558	1.00	6.48	C	C
  ATOM	7431	CZ	TYR	I	44	17.946	−17.240	−13.287	1.00	6.88	C	C
  ATOM	7432	OH	TYR	I	44	18.989	−16.371	−13.062	1.00	7.50	C	O
  ATOM	7433	CE2	TYR	I	44	17.438	−17.984	−12.245	1.00	6.68	C	C
  ATOM	7434	CD2	TYR	I	44	16.388	−18.851	−12.475	1.00	5.91	C	C
  ATOM	7435	C	TYR	I	44	13.859	−22.275	−14.065	1.00	6.86	C	C
  ATOM	7436	O	TYR	I	44	13.320	−22.602	−15.122	1.00	7.14	C	O
  ATOM	7437	N	LEU	I	45	13.309	−22.498	−12.875	1.00	6.44	C	N
  ATOM	7438	CA	LEU	I	45	12.131	−23.342	−12.733	1.00	6.12	C	C
  ATOM	7439	CB	LEU	I	45	12.479	−24.650	−12.019	1.00	6.31	C	C
  ATOM	7440	CG	LEU	I	45	13.457	−25.536	−12.798	1.00	6.38	C	C
  ATOM	7441	CD1	LEU	I	45	14.250	−26.452	−11.877	1.00	7.05	C	C
  ATOM	7442	CD2	LEU	I	45	12.736	−26.332	−13.874	1.00	7.05	C	C
  ATOM	7443	C	LEU	I	45	10.924	−22.641	−12.096	1.00	5.84	C	C
  ATOM	7444	O	LEU	I	45	10.954	−22.268	−10.921	1.00	5.94	C	O
  ATOM	7445	N	SER	I	46	9.806	−22.689	−12.821	1.00	5.43	C	N
  ATOM	7446	CA	SER	I	46	8.639	−21.822	−12.611	1.00	5.26	C	C
  ATOM	7447	CB	SER	I	46	7.803	−21.796	−13.891	1.00	5.21	C	C
  ATOM	7448	OG	SER	I	46	7.441	−23.112	−14.280	1.00	4.95	C	O
  ATOM	7449	C	SER	I	46	7.793	−22.404	−11.485	1.00	5.51	C	C
  ATOM	7450	O	SER	I	46	8.086	−23.500	−11.013	1.00	6.03	C	O
  ATOM	7451	N	ALA	I	47	6.787	−21.679	−11.001	1.00	5.24	C	N
  ATOM	7452	CA	ALA	I	47	6.265	−22.042	−9.688	1.00	4.83	C	C
  ATOM	7453	CB	ALA	I	47	7.391	−22.094	−8.675	1.00	5.01	C	C
  ATOM	7454	C	ALA	I	47	5.061	−21.315	−9.106	1.00	4.35	C	C
  ATOM	7455	O	ALA	I	47	5.100	−20.099	−8.920	1.00	4.45	C	O
  ATOM	7456	N	LEU	I	48	4.246	−22.119	−8.428	1.00	3.67	C	N
  ATOM	7457	CA	LEU	I	48	3.120	−21.630	−7.645	1.00	3.15	C	C
  ATOM	7458	CB	LEU	I	48	1.802	−21.948	−8.359	1.00	2.78	C	C
  ATOM	7459	CG	LEU	I	48	1.785	−21.864	−9.889	1.00	2.18	C	C
  ATOM	7460	CD1	LEU	I	48	0.350	−21.834	−10.383	1.00	2.00	C	C
  ATOM	7461	CD2	LEU	I	48	2.544	−20.643	−10.386	1.00	3.94	C	C
  ATOM	7462	C	LEU	I	48	3.128	−22.240	−6.239	1.00	3.06	C	C
  ATOM	7463	O	LEU	I	48	3.433	−23.422	−6.065	1.00	3.27	C	O
  ATOM	7464	N	ARG	I	49	2.926	−21.394	−5.233	1.00	2.91	C	N
  ATOM	7465	CA	ARG	I	49	2.903	−21.846	−3.846	1.00	2.88	C	C
  ATOM	7466	CB	ARG	I	49	3.036	−20.658	−2.887	1.00	2.69	C	C
  ATOM	7467	CG	ARG	I	49	3.904	−20.942	−1.663	1.00	2.15	C	C
  ATOM	7468	CD	ARG	I	49	3.321	−20.322	−0.404	1.00	2.00	C	C
  ATOM	7469	NE	ARG	I	49	2.284	−21.163	0.190	1.00	5.18	C	N
  ATOM	7470	CZ	ARG	I	49	1.050	−20.748	0.463	1.00	7.68	C	C
  ATOM	7471	NH1	ARG	I	49	0.699	−19.492	0.217	1.00	8.32	C	N
  ATOM	7472	NH2	ARG	I	49	0.181	−21.570	1.036	1.00	8.12	C	N
  ATOM	7473	C	ARG	I	49	1.625	−22.619	−3.544	1.00	3.09	C	C
  ATOM	7474	O	ARG	I	49	0.527	−22.170	−3.873	1.00	3.08	C	O
  ATOM	7475	N	THR	I	50	1.774	−23.803	−2.956	1.00	3.37	C	N
  ATOM	7476	CA	THR	I	50	0.625	−24.551	−2.456	1.00	3.55	C	C
  ATOM	7477	CB	THR	I	50	0.042	−25.503	−3.512	1.00	3.25	C	C
  ATOM	7478	OG1	THR	I	50	1.091	−26.292	−4.086	1.00	2.66	C	O
  ATOM	7479	CG2	THR	I	50	−0.670	−24.723	−4.605	1.00	3.46	C	C
  ATOM	7480	C	THR	I	50	0.919	−25.349	−1.195	1.00	4.07	C	C
  ATOM	7481	O	THR	I	50	0.137	−25.308	−0.247	1.00	4.35	C	O
  ATOM	7482	N	GLY	I	51	1.892	−26.248	−1.274	1.00	4.24	C	N
  ATOM	7483	CA	GLY	I	51	2.393	−26.864	−0.060	1.00	4.78	C	C
  ATOM	7484	C	GLY	I	51	2.414	−25.769	0.981	1.00	4.98	C	C
  ATOM	7485	O	GLY	I	51	3.082	−24.754	0.786	1.00	5.00	C	O
  ATOM	7486	N	TRP	I	52	1.481	−25.829	1.923	1.00	5.34	C	N
  ATOM	7487	CA	TRP	I	52	1.440	−24.823	2.974	1.00	5.42	C	C
  ATOM	7488	CB	TRP	I	52	0.124	−24.048	2.951	1.00	5.75	C	C
  ATOM	7489	CG	TRP	I	52	−0.090	−23.284	1.696	1.00	6.38	C	C
  ATOM	7490	CD1	TRP	I	52	−1.020	−23.544	0.734	1.00	7.27	C	C
  ATOM	7491	NE1	TRP	I	52	−0.899	−22.647	−0.297	1.00	7.46	C	N
  ATOM	7492	CE2	TRP	I	52	0.129	−21.785	−0.018	1.00	7.15	C	C
  ATOM	7493	CD2	TRP	I	52	0.671	−22.164	1.228	1.00	7.02	C	C
  ATOM	7494	CE3	TRP	I	52	1.741	−21.428	1.752	1.00	6.83	C	C
  ATOM	7495	CZ3	TRP	I	52	2.221	−20.347	1.027	1.00	6.73	C	C
  ATOM	7496	CH2	TRP	I	52	1.664	−20.000	−0.214	1.00	7.13	C	C
  ATOM	7497	CZ2	TRP	I	52	0.621	−20.706	−0.751	1.00	6.82	C	C
  ATOM	7498	C	TRP	I	52	1.680	−25.408	4.354	1.00	5.34	C	C
  ATOM	7499	O	TRP	I	52	1.222	−26.507	4.667	1.00	5.47	C	O
  ATOM	7500	N	TYR	I	53	2.237	−24.581	5.227	1.00	5.29	C	N
  ATOM	7501	CA	TYR	I	53	2.492	−24.977	6.598	1.00	5.58	C	C
  ATOM	7502	CB	TYR	I	53	4.002	−25.087	6.829	1.00	5.51	C	C
  ATOM	7503	CG	TYR	I	53	4.401	−25.463	8.239	1.00	6.59	C	C
  ATOM	7504	CD1	TYR	I	53	4.613	−26.791	8.591	1.00	8.25	C	C
  ATOM	7505	CE1	TYR	I	53	5.010	−27.136	9.872	1.00	9.40	C	C
  ATOM	7506	CZ	TYR	I	53	5.280	−26.145	10.790	1.00	9.24	C	C
  ATOM	7507	OH	TYR	I	53	5.693	−26.480	12.058	1.00	9.61	C	O
  ATOM	7508	CE2	TYR	I	53	5.162	−24.818	10.437	1.00	8.78	C	C
  ATOM	7509	CD2	TYR	I	53	4.758	−24.485	9.157	1.00	7.93	C	C
  ATOM	7510	C	TYR	I	53	1.869	−23.950	7.539	1.00	5.74	C	C
  ATOM	7511	O	TYR	I	53	2.281	−22.790	7.558	1.00	6.19	C	O
  ATOM	7512	N	THR	I	54	0.756	−24.328	8.159	1.00	6.04	C	N
  ATOM	7513	CA	THR	I	54	0.075	−23.456	9.109	1.00	6.67	C	C
  ATOM	7514	CB	THR	I	54	−1.298	−24.028	9.513	1.00	6.97	C	C
  ATOM	7515	OG1	THR	I	54	−2.247	−23.782	8.467	1.00	7.51	C	O
  ATOM	7516	CG2	THR	I	54	−1.790	−23.384	10.800	1.00	7.98	C	C
  ATOM	7517	C	THR	I	54	0.928	−23.266	10.359	1.00	6.97	C	C
  ATOM	7518	O	THR	I	54	1.713	−24.141	10.723	1.00	7.32	C	O
  ATOM	7519	N	SER	I	55	0.775	−22.120	11.013	1.00	7.24	C	N
  ATOM	7520	CA	SER	I	55	1.085	−22.019	12.433	1.00	7.65	C	C
  ATOM	7521	CB	SER	I	55	2.589	−21.862	12.654	1.00	7.69	C	C
  ATOM	7522	OG	SER	I	55	2.868	−21.507	13.998	1.00	7.51	C	O
  ATOM	7523	C	SER	I	55	0.338	−20.878	13.104	1.00	8.03	C	C
  ATOM	7524	O	SER	I	55	0.238	−19.778	12.560	1.00	8.43	C	O
  ATOM	7525	N	VAL	I	56	−0.094	−21.121	14.335	1.00	8.14	C	N
  ATOM	7526	CA	VAL	I	56	−1.029	−20.234	15.006	1.00	8.41	C	C
  ATOM	7527	CB	VAL	I	56	−2.209	−21.014	15.598	1.00	8.72	C	C
  ATOM	7528	CG1	VAL	I	56	−3.403	−20.094	15.787	1.00	9.29	C	C
  ATOM	7529	CG2	VAL	I	56	−2.569	−22.184	14.695	1.00	9.51	C	C
  ATOM	7530	C	VAL	I	56	−0.331	−19.478	16.123	1.00	8.19	C	C
  ATOM	7531	O	VAL	I	56	0.075	−20.066	17.122	1.00	8.54	C	O
  ATOM	7532	N	ILE	I	57	−0.187	−18.171	15.943	1.00	7.91	C	N
  ATOM	7533	CA	ILE	I	57	0.639	−17.368	16.832	1.00	7.64	C	C
  ATOM	7534	CB	ILE	I	57	1.675	−16.539	16.051	1.00	7.35	C	C
  ATOM	7535	CG1	ILE	I	57	2.612	−17.461	15.262	1.00	7.25	C	C
  ATOM	7536	CD1	ILE	I	57	3.526	−16.730	14.294	1.00	8.42	C	C
  ATOM	7537	CG2	ILE	I	57	2.457	−15.632	16.993	1.00	7.52	C	C
  ATOM	7538	C	ILE	I	57	−0.222	−16.445	17.680	1.00	7.69	C	C
  ATOM	7539	O	ILE	I	57	−1.150	−15.810	17.178	1.00	7.79	C	O
  ATOM	7540	N	THR	I	58	−0.024	−16.523	18.989	1.00	7.85	C	N
  ATOM	7541	CA	THR	I	58	−0.929	−15.900	19.938	1.00	8.15	C	C
  ATOM	7542	CB	THR	I	58	−1.660	−16.954	20.777	1.00	8.14	C	C
  ATOM	7543	OG1	THR	I	58	−1.584	−18.225	20.120	1.00	8.62	C	O
  ATOM	7544	CG2	THR	I	58	−3.116	−16.566	20.957	1.00	7.94	C	C
  ATOM	7545	C	THR	I	58	−0.152	−14.983	20.869	1.00	8.20	C	C
  ATOM	7546	O	THR	I	58	0.808	−15.408	21.510	1.00	8.18	C	O
  ATOM	7547	N	ILE	I	59	−0.539	−13.713	20.903	1.00	8.54	C	N
  ATOM	7548	CA	ILE	I	59	0.226	−12.694	21.616	1.00	9.23	C	C
  ATOM	7549	CB	ILE	I	59	0.863	−11.690	20.634	1.00	8.92	C	C
  ATOM	7550	CG1	ILE	I	59	1.868	−12.391	19.717	1.00	9.27	C	C
  ATOM	7551	CD1	ILE	I	59	2.587	−11.453	18.770	1.00	10.89	C	C
  ATOM	7552	CG2	ILE	I	59	1.516	−10.544	21.390	1.00	8.74	C	C
  ATOM	7553	C	ILE	I	59	−0.691	−11.920	22.553	1.00	10.02	C	C
  ATOM	7554	O	ILE	I	59	−1.692	−11.357	22.113	1.00	10.20	C	O
  ATOM	7555	N	GLU	I	60	−0.439	−12.007	23.853	1.00	10.95	C	N
  ATOM	7556	CA	GLU	I	60	−1.462	−11.602	24.808	1.00	12.13	C	C
  ATOM	7557	CB	GLU	I	60	−0.963	−11.829	26.248	1.00	12.44	C	C
  ATOM	7558	CG	GLU	I	60	−0.554	−13.288	26.547	1.00	15.04	C	C
  ATOM	7559	CD	GLU	I	60	−0.560	−13.630	28.036	1.00	19.34	C	C
  ATOM	7560	OE1	GLU	I	60	0.413	−13.267	28.733	1.00	20.63	C	O
  ATOM	7561	OE2	GLU	I	60	−1.469	−14.368	28.478	1.00	21.19	C	O
  ATOM	7562	C	GLU	I	60	−1.856	−10.131	24.547	1.00	12.46	C	C
  ATOM	7563	O	GLU	I	60	−0.984	−9.259	24.567	1.00	12.68	C	O
  ATOM	7564	N	LEU	I	61	−3.138	−9.818	24.298	1.00	12.80	C	N
  ATOM	7565	CA	LEU	I	61	−3.535	−8.473	24.718	1.00	12.71	C	C
  ATOM	7566	CB	LEU	I	61	−5.021	−8.120	24.699	1.00	12.55	C	C
  ATOM	7567	CG	LEU	I	61	−5.052	−6.753	25.421	1.00	12.39	C	C
  ATOM	7568	CD1	LEU	I	61	−4.358	−5.650	24.625	1.00	13.14	C	C
  ATOM	7569	CD2	LEU	I	61	−6.421	−6.318	25.899	1.00	12.50	C	C
  ATOM	7570	C	LEU	I	61	−3.097	−8.585	26.133	1.00	12.94	C	C
  ATOM	7571	O	LEU	I	61	−3.578	−9.474	26.843	1.00	12.78	C	O
  ATOM	7572	N	SER	I	62	−1.846	−8.190	26.260	1.00	13.61	C	N
  ATOM	7573	CA	SER	I	62	−1.183	−8.231	27.527	1.00	14.70	C	C
  ATOM	7574	CB	SER	I	62	0.326	−8.252	27.325	1.00	14.52	C	C
  ATOM	7575	OG	SER	I	62	0.724	−9.440	26.664	1.00	14.80	C	O
  ATOM	7576	C	SER	I	62	−1.605	−6.983	28.261	1.00	15.48	C	C
  ATOM	7577	O	SER	I	62	−1.206	−5.880	27.893	1.00	15.50	C	O
  ATOM	7578	N	ASN	I	63	−2.602	−7.135	29.121	1.00	16.61	C	N
  ATOM	7579	CA	ASN	I	63	−3.232	−5.978	29.716	1.00	17.77	C	C
  ATOM	7580	CB	ASN	I	63	−4.616	−6.314	30.263	1.00	17.73	C	C
  ATOM	7581	CG	ASN	I	63	−5.566	−5.142	30.175	1.00	18.52	C	C
  ATOM	7582	OD1	ASN	I	63	−5.140	−3.987	30.185	1.00	18.29	C	O
  ATOM	7583	ND2	ASN	I	63	−6.837	−5.433	29.933	1.00	19.40	C	N
  ATOM	7584	C	ASN	I	63	−2.369	−5.335	30.787	1.00	18.53	C	C
  ATOM	7585	O	ASN	I	63	−1.589	−6.007	31.463	1.00	18.82	C	O
  ATOM	7586	N	ILE	I	64	−2.403	−4.010	30.819	1.00	19.60	C	N
  ATOM	7587	CA	ILE	I	64	−1.812	−3.252	31.908	1.00	21.04	C	C
  ATOM	7588	CB	ILE	I	64	−1.433	−1.836	31.448	1.00	20.60	C	C
  ATOM	7589	CG1	ILE	I	64	−0.845	−1.878	30.038	1.00	20.13	C	C
  ATOM	7590	CD1	ILE	I	64	−0.383	−0.534	29.522	1.00	20.19	C	C
  ATOM	7591	CG2	ILE	I	64	−0.451	−1.211	32.416	1.00	20.74	C	C
  ATOM	7592	C	ILE	I	64	−2.778	−3.148	33.082	1.00	22.58	C	C
  ATOM	7593	O	ILE	I	64	−3.951	−2.832	32.900	1.00	23.07	C	O
  ATOM	7594	N	LYS	I	65	−2.259	−3.322	34.292	1.00	24.21	C	N
  ATOM	7595	CA	LYS	I	65	−2.904	−2.779	35.482	1.00	25.86	C	C
  ATOM	7596	CB	LYS	I	65	−2.929	−3.822	36.602	1.00	25.90	C	C
  ATOM	7597	CG	LYS	I	65	−2.083	−5.056	36.323	1.00	26.69	C	C
  ATOM	7598	CD	LYS	I	65	−0.616	−4.698	36.160	1.00	28.26	C	C
  ATOM	7599	CE	LYS	I	65	0.273	−5.606	36.992	1.00	28.67	C	C
  ATOM	7600	NZ	LYS	I	65	1.600	−4.983	37.247	1.00	28.95	C	N
  ATOM	7601	C	LYS	I	65	−2.215	−1.500	35.961	1.00	26.81	C	C
  ATOM	7602	O	LYS	I	65	−1.160	−1.557	36.591	1.00	26.72	C	O
  ATOM	7603	N	GLU	I	66	−2.903	−0.371	35.798	1.00	27.90	C	N
  ATOM	7604	CA	GLU	I	66	−2.291	0.962	35.878	1.00	28.82	C	C
  ATOM	7605	CB	GLU	I	66	−3.184	1.983	35.163	1.00	28.88	C	C
  ATOM	7606	CG	GLU	I	66	−3.354	3.309	35.901	1.00	30.33	C	C
  ATOM	7607	CD	GLU	I	66	−4.570	4.084	35.431	1.00	33.17	C	C
  ATOM	7608	OE1	GLU	I	66	−4.590	5.323	35.595	1.00	35.05	C	O
  ATOM	7609	OE2	GLU	I	66	−5.488	3.457	34.860	1.00	33.14	C	O
  ATOM	7610	C	GLU	I	66	−2.102	1.393	37.333	1.00	29.12	C	C
  ATOM	7611	O	GLU	I	66	−3.002	1.204	38.148	1.00	29.28	C	O
  ATOM	7612	N	ASN	I	67	−0.975	2.029	37.653	1.00	29.32	C	N
  ATOM	7613	CA	ASN	I	67	−0.630	2.266	39.065	1.00	29.39	C	C
  ATOM	7614	CB	ASN	I	67	0.664	1.550	39.473	1.00	29.62	C	C
  ATOM	7615	CG	ASN	I	67	0.399	0.206	40.133	1.00	29.84	C	C
  ATOM	7616	OD1	ASN	I	67	−0.154	0.147	41.233	1.00	29.93	C	O
  ATOM	7617	ND2	ASN	I	67	0.655	−0.875	39.400	1.00	29.22	C	N
  ATOM	7618	C	ASN	I	67	−0.670	3.712	39.571	1.00	29.15	C	C
  ATOM	7619	O	ASN	I	67	0.352	4.281	39.962	1.00	29.06	C	O
  ATOM	7620	N	LYS	I	68	−1.872	4.284	39.584	1.00	28.87	C	N
  ATOM	7621	CA	LYS	I	68	−2.302	5.212	40.630	1.00	28.78	C	C
  ATOM	7622	CB	LYS	I	68	−3.436	4.596	41.454	1.00	28.89	C	C
  ATOM	7623	CG	LYS	I	68	−4.461	3.838	40.617	1.00	29.26	C	C
  ATOM	7624	CD	LYS	I	68	−5.357	2.964	41.483	1.00	29.68	C	C
  ATOM	7625	CE	LYS	I	68	−5.626	3.615	42.835	1.00	29.46	C	C
  ATOM	7626	NZ	LYS	I	68	−6.764	2.972	43.555	1.00	29.58	C	N
  ATOM	7627	C	LYS	I	68	−1.171	5.722	41.535	1.00	28.60	C	C
  ATOM	7628	O	LYS	I	68	−1.082	5.347	42.703	1.00	28.64	C	O
  ATOM	7629	N	CYS	I	69	−0.274	6.525	40.961	1.00	28.09	C	N
  ATOM	7630	CA	CYS	I	69	0.585	7.455	41.715	1.00	27.63	C	C
  ATOM	7631	CB	CYS	I	69	2.068	7.270	41.326	1.00	27.07	C	C
  ATOM	7632	SG	CYS	I	69	2.742	8.433	40.058	1.00	28.01	C	S
  ATOM	7633	C	CYS	I	69	0.143	8.893	41.433	1.00	27.69	C	C
  ATOM	7634	O	CYS	I	69	−0.588	9.134	40.473	1.00	27.41	C	O
  ATOM	7635	N	ASN	I	70	0.615	9.855	42.226	1.00	28.06	C	N
  ATOM	7636	CA	ASN	I	70	0.603	11.259	41.794	1.00	28.87	C	C
  ATOM	7637	CB	ASN	I	70	−0.364	12.119	42.626	1.00	30.52	C	C
  ATOM	7638	CG	ASN	I	70	−1.286	11.299	43.518	1.00	39.60	C	C
  ATOM	7639	OD1	ASN	I	70	−2.181	10.602	43.040	1.00	44.97	C	O
  ATOM	7640	ND2	ASN	I	70	−1.073	11.402	44.831	1.00	51.04	C	N
  ATOM	7641	C	ASN	I	70	1.978	11.934	41.727	1.00	26.97	C	C
  ATOM	7642	O	ASN	I	70	2.563	12.257	42.761	1.00	26.50	C	O
  ATOM	7643	N	GLY	I	71	2.371	12.349	40.523	1.00	25.46	C	N
  ATOM	7644	CA	GLY	I	71	3.643	13.052	40.316	1.00	23.67	C	C
  ATOM	7645	C	GLY	I	71	3.501	14.565	40.288	1.00	22.81	C	C
  ATOM	7646	O	GLY	I	71	2.415	15.094	40.516	1.00	22.79	C	O
  ATOM	7647	N	THR	I	72	4.585	15.268	39.975	1.00	21.93	C	N
  ATOM	7648	CA	THR	I	72	4.526	16.721	39.835	1.00	21.30	C	C
  ATOM	7649	CB	THR	I	72	5.923	17.363	39.940	1.00	21.12	C	C
  ATOM	7650	OG1	THR	I	72	6.624	17.194	38.702	1.00	19.87	C	O
  ATOM	7651	CG2	THR	I	72	6.725	16.723	41.063	1.00	20.76	C	C
  ATOM	7652	C	THR	I	72	3.864	17.132	38.518	1.00	21.50	C	C
  ATOM	7653	O	THR	I	72	4.384	16.852	37.438	1.00	21.85	C	O
  ATOM	7654	N	ASP	I	73	2.703	17.774	38.617	1.00	21.43	C	N
  ATOM	7655	CA	ASP	I	73	1.767	17.891	37.494	1.00	21.46	C	C
  ATOM	7656	CB	ASP	I	73	2.361	18.743	36.368	1.00	21.69	C	C
  ATOM	7657	CG	ASP	I	73	1.457	18.812	35.149	1.00	22.46	C	C
  ATOM	7658	OD1	ASP	I	73	0.542	17.969	35.035	1.00	23.01	C	O
  ATOM	7659	OD2	ASP	I	73	1.682	19.690	34.289	1.00	23.09	C	O
  ATOM	7660	C	ASP	I	73	1.323	16.536	36.950	1.00	20.96	C	C
  ATOM	7661	O	ASP	I	73	2.128	15.792	36.390	1.00	20.61	C	O
  ATOM	7662	N	ALA	I	74	0.019	16.285	36.989	1.00	20.42	C	N
  ATOM	7663	CA	ALA	I	74	−0.512	14.977	36.622	1.00	20.38	C	C
  ATOM	7664	CB	ALA	I	74	−1.027	14.248	37.855	1.00	20.11	C	C
  ATOM	7665	C	ALA	I	74	−1.602	15.058	35.556	1.00	20.45	C	C
  ATOM	7666	O	ALA	I	74	−2.490	14.208	35.509	1.00	20.46	C	O
  ATOM	7667	N	LYS	I	75	−1.583	16.114	34.750	1.00	20.67	C	N
  ATOM	7668	CA	LYS	I	75	−2.473	16.188	33.596	1.00	20.99	C	C
  ATOM	7669	CB	LYS	I	75	−2.421	17.583	32.970	1.00	21.20	C	C
  ATOM	7670	CG	LYS	I	75	−2.967	18.684	33.865	1.00	22.02	C	C
  ATOM	7671	CD	LYS	I	75	−1.927	19.766	34.106	1.00	23.66	C	C
  ATOM	7672	CE	LYS	I	75	−1.971	20.263	35.542	1.00	24.93	C	C
  ATOM	7673	NZ	LYS	I	75	−0.622	20.658	36.036	1.00	25.55	C	N
  ATOM	7674	C	LYS	I	75	−2.025	15.144	32.587	1.00	20.92	C	C
  ATOM	7675	O	LYS	I	75	−2.801	14.680	31.751	1.00	20.92	C	O
  ATOM	7676	N	VAL	I		76	−0.731	14.853	32.634	1.00	20.63	C	N
  ATOM	7677	CA	VAL	I	76	−0.147	13.700	31.971	1.00	20.36	C	C
  ATOM	7678	CB	VAL	I	76	1.386	13.792	32.017	1.00	20.25	C	C
  ATOM	7679	CG1	VAL	I	76	2.009	12.475	31.612	1.00	20.82	C	C
  ATOM	7680	CG2	VAL	I	76	1.873	14.923	31.130	1.00	20.09	C	C
  ATOM	7681	C	VAL	I	76	−0.586	12.393	32.629	1.00	20.29	C	C
  ATOM	7682	O	VAL	I		76	−0.452	12.225	33.840	1.00	20.21	C	O
  ATOM	7683	N	LYS	I	77	−1.106	11.471	31.826	1.00	20.17	C	N
  ATOM	7684	CA	LYS	I	77	−1.642	10.218	32.348	1.00	20.17	C	C
  ATOM	7685	CB	LYS	I	77	−3.103	10.393	32.760	1.00	20.62	C	C
  ATOM	7686	CG	LYS	I	77	−3.297	10.767	34.215	1.00	23.31	C	C
  ATOM	7687	CD	LYS	I	77	−4.508	11.664	34.388	1.00	26.74	C	C
  ATOM	7688	CE	LYS	I	77	−4.529	12.291	35.767	1.00	28.32	C	C
  ATOM	7689	NZ	LYS	I	77	−5.869	12.836	36.105	1.00	29.66	C	N
  ATOM	7690	C	LYS	I	77	−1.523	9.105	31.317	1.00	19.45	C	C
  ATOM	7691	O	LYS	I	77	−2.517	8.496	30.921	1.00	19.36	C	O
  ATOM	7692	N	LEU	I	78	−0.297	8.863	30.871	1.00	18.70	C	N
  ATOM	7693	CA	LEU	I	78	−0.064	8.098	29.659	1.00	17.98	C	C
  ATOM	7694	CB	LEU	I	78	1.419	7.775	29.528	1.00	17.72	C	C
  ATOM	7695	CG	LEU	I	78	2.275	9.033	29.591	1.00	17.51	C	C
  ATOM	7696	CD1	LEU	I	78	3.746	8.676	29.494	1.00	17.41	C	C
  ATOM	7697	CD2	LEU	I	78	1.859	9.984	28.480	1.00	17.62	C	C
  ATOM	7698	C	LEU	I	78	−0.882	6.820	29.656	1.00	17.77	C	C
  ATOM	7699	O	LEU	I	78	−1.665	6.576	28.739	1.00	17.89	C	O
  ATOM	7700	N	ILE	I	79	−0.749	6.036	30.717	1.00	17.29	C	N
  ATOM	7701	CA	ILE	I	79	−1.319	4.703	30.726	1.00	17.00	C	C
  ATOM	7702	CB	ILE	I	79	−0.968	3.948	32.005	1.00	16.96	C	C
  ATOM	7703	CG1	ILE	I	79	0.550	3.801	32.113	1.00	17.21	C	C
  ATOM	7704	CD1	ILE	I	79	1.020	3.244	33.429	1.00	17.51	C	C
  ATOM	7705	CG2	ILE	I	79	−1.643	2.587	32.005	1.00	17.30	C	C
  ATOM	7706	C	ILE	I	79	−2.828	4.750	30.547	1.00	16.83	C	C
  ATOM	7707	O	ILE	I	79	−3.365	4.160	29.609	1.00	17.02	C	O
  ATOM	7708	N	LYS	I	80	−3.616	5.565	31.220	1.00	16.55	C	N
  ATOM	7709	CA	LYS	I	80	−5.043	5.447	30.835	1.00	16.38	C	C
  ATOM	7710	CB	LYS	I	80	−5.918	6.332	31.725	1.00	16.73	C	C
  ATOM	7711	CG	LYS	I	80	−7.025	7.055	30.971	1.00	17.99	C	C
  ATOM	7712	CD	LYS	I	80	−8.237	7.295	31.854	1.00	20.71	C	C
  ATOM	7713	CE	LYS	I	80	−9.171	6.094	31.833	1.00	22.92	C	C
  ATOM	7714	NZ	LYS	I	80	−8.439	4.818	32.068	1.00	24.75	C	N
  ATOM	7715	C	LYS	I	80	−5.386	5.716	29.328	1.00	15.79	C	C
  ATOM	7716	O	LYS	I	80	−6.140	4.942	28.677	1.00	15.32	C	O
  ATOM	7717	N	GLN	I	81	−4.802	6.770	28.763	1.00	15.48	C	N
  ATOM	7718	CA	GLN	I	81	−5.092	7.178	27.383	1.00	15.33	C	C
  ATOM	7719	CB	GLN	I	81	−4.378	8.495	27.068	1.00	15.70	C	C
  ATOM	7720	CG	GLN	I	81	−4.522	9.557	28.146	1.00	17.88	C	C
  ATOM	7721	CD	GLN	I	81	−3.631	10.759	27.903	1.00	20.46	C	C
  ATOM	7722	OE1	GLN	I	81	−3.065	10.916	26.822	1.00	21.59	C	O
  ATOM	7723	NE2	GLN	I	81	−3.498	11.613	28.913	1.00	20.26	C	N
  ATOM	7724	C	GLN	I	81	−4.708	6.125	26.341	1.00	14.63	C	C
  ATOM	7725	O	GLN	I	81	−5.438	5.881	25.360	1.00	14.60	C	O
  ATOM	7726	N	GLU	I	82	−3.556	5.500	26.560	1.00	13.81	C	N
  ATOM	7727	CA	GLU	I	82	−3.078	4.470	25.657	1.00	13.37	C	C
  ATOM	7728	CB	GLU	I	82	−1.705	3.958	26.094	1.00	13.20	C	C
  ATOM	7729	CG	GLU	I	82	−0.528	4.666	25.439	1.00	15.04	C	C
  ATOM	7730	CD	GLU	I	82	−0.472	4.436	23.942	1.00	17.51	C	C
  ATOM	7731	OE1	GLU	I	82	0.319	3.576	23.502	1.00	18.22	C	O
  ATOM	7732	OE2	GLU	I	82	−1.211	5.121	23.205	1.00	17.87	C	O
  ATOM	7733	C	GLU	I	82	−4.079	3.333	25.659	1.00	12.99	C	C
  ATOM	7734	O	GLU	I	82	−4.400	2.779	24.610	1.00	12.89	C	O
  ATOM	7735	N	LEU	I	83	−4.593	3.001	26.838	1.00	12.89	C	N
  ATOM	7736	CA	LEU	I	83	−5.558	1.919	26.944	1.00	13.08	C	C
  ATOM	7737	CB	LEU	I	83	−5.923	1.668	28.407	1.00	13.26	C	C
  ATOM	7738	CG	LEU	I		83	−4.774	1.250	29.325	1.00	14.18	C	C
  ATOM	7739	CD1	LEU	I	83	−5.293	0.948	30.721	1.00	15.11	C	C
  ATOM	7740	CD2	LEU	I	83	−4.036	0.051	28.748	1.00	14.79	C	C
  ATOM	7741	C	LEU	I	83	−6.808	2.252	26.144	1.00	13.18	C	C
  ATOM	7742	O	LEU	I	83	−7.310	1.410	25.386	1.00	13.05	C	O
  ATOM	7743	N	ASP	I	84	−7.286	3.490	26.251	1.00	13.56	C	N
  ATOM	7744	CA	ASP	I	84	−8.478	3.834	25.467	1.00	14.15	C	C
  ATOM	7745	CB	ASP	I	84	−8.946	5.258	25.781	1.00	14.80	C	C
  ATOM	7746	CG	ASP	I	84	−9.044	5.529	27.268	1.00	18.26	C	C
  ATOM	7747	OD1	ASP	I	84	−10.133	5.330	27.846	1.00	21.11	C	O
  ATOM	7748	OD2	ASP	I	84	−8.032	5.959	27.858	1.00	22.12	C	O
  ATOM	7749	C	ASP	I	84	−8.226	3.703	23.954	1.00	13.56	C	C
  ATOM	7750	O	ASP	I	84	−9.062	3.149	23.192	1.00	13.70	C	O
  ATOM	7751	N	LYS	I	85	−7.062	4.182	23.517	1.00	12.87	C	N
  ATOM	7752	CA	LYS	I	85	−6.752	4.121	22.089	1.00	12.31	C	C
  ATOM	7753	CB	LYS	I	85	−5.424	4.816	21.793	1.00	12.41	C	C
  ATOM	7754	CG	LYS	I	85	−5.118	4.954	20.308	1.00	12.26	C	C
  ATOM	7755	CD	LYS	I	85	−3.659	5.305	20.076	1.00	12.72	C	C
  ATOM	7756	CE	LYS	I	85	−2.751	4.171	20.519	1.00	14.40	C	C
  ATOM	7757	NZ	LYS	I	85	−1.316	4.445	20.230	1.00	16.45	C	N
  ATOM	7758	C	LYS	I	85	−6.691	2.671	21.621	1.00	11.85	C	C
  ATOM	7759	O	LYS	I	85	−7.187	2.312	20.537	1.00	11.66	C	O
  ATOM	7760	N	TYR	I	86	−6.085	1.836	22.457	1.00	11.32	C	N
  ATOM	7761	CA	TYR	I	86	−5.931	0.432	22.135	1.00	11.07	C	C
  ATOM	7762	CB	TYR	I	86	−5.115	−0.290	23.203	1.00	11.12	C	C
  ATOM	7763	CG	TYR	I	86	−5.391	−1.773	23.243	1.00	11.30	C	C
  ATOM	7764	CD1	TYR	I	86	−4.884	−2.621	22.268	1.00	12.16	C	C
  ATOM	7765	CE1	TYR	I	86	−5.140	−3.977	22.297	1.00	12.39	C	C
  ATOM	7766	CZ	TYR	I	86	−5.916	−4.500	23.308	1.00	12.62	C	C
  ATOM	7767	OH	TYR	I	86	−6.174	−5.852	23.343	1.00	12.72	C	O
  ATOM	7768	CE2	TYR	I	86	−6.434	−3.680	24.286	1.00	11.38	C	C
  ATOM	7769	CD2	TYR	I	86	−6.173	−2.325	24.248	1.00	11.05	C	C
  ATOM	7770	C	TYR	I	86	−7.290	−0.219	22.008	1.00	10.75	C	C
  ATOM	7771	O	TYR	I	86	−7.517	−1.004	21.098	1.00	10.45	C	O
  ATOM	7772	N	LYS	I	87	−8.204	0.123	22.908	1.00	10.66	C	N
  ATOM	7773	CA	LYS	I	87	−9.533	−0.467	22.847	1.00	11.03	C	C
  ATOM	7774	CB	LYS	I	87	−10.389	0.010	24.021	1.00	11.36	C	C
  ATOM	7775	CG	LYS	I	87	−9.786	−0.270	25.384	1.00	12.79	C	C
  ATOM	7776	CD	LYS	I	87	−10.675	0.264	26.495	1.00	14.76	C	C
  ATOM	7777	CE	LYS	I	87	−10.068	−0.017	27.859	1.00	15.29	C	C
  ATOM	7778	NZ	LYS	I	87	−10.924	0.485	28.970	1.00	16.27	C	N
  ATOM	7779	C	LYS	I	87	−10.208	−0.098	21.530	1.00	10.83	C	C
  ATOM	7780	O	LYS	I	87	−10.800	−0.963	20.857	1.00	11.11	C	O
  ATOM	7781	N	ASN	I	88	−10.089	1.168	21.126	1.00	10.52	C	N
  ATOM	7782	CA	ASN	I	88	−10.721	1.545	19.858	1.00	10.21	C	C
  ATOM	7783	CB	ASN	I	88	−10.592	3.050	19.614	1.00	10.61	C	C
  ATOM	7784	CG	ASN	I	88	−11.178	3.480	18.281	1.00	11.81	C	C
  ATOM	7785	OD1	ASN	I	88	−12.114	2.864	17.772	1.00	12.97	C	O
  ATOM	7786	ND2	ASN	I	88	−10.625	4.543	17.709	1.00	13.82	C	N
  ATOM	7787	C	ASN	I	88	−10.128	0.767	18.674	1.00	9.42	C	C
  ATOM	7788	O	ASN	I	88	−10.858	0.237	17.796	1.00	8.94	C	O
  ATOM	7789	N	ALA	I	89	−8.802	0.652	18.677	1.00	8.77	C	N
  ATOM	7790	CA	ALA	I	89	−8.130	−0.041	17.586	1.00	8.21	C	C
  ATOM	7791	CB	ALA	I	89	−6.623	0.040	17.751	1.00	7.99	C	C
  ATOM	7792	C	ALA	I	89	−8.588	−1.493	17.543	1.00	7.78	C	C
  ATOM	7793	O	ALA	I	89	−8.826	−2.057	16.472	1.00	7.88	C	O
  ATOM	7794	N	VAL	I		90	−8.718	−2.086	18.724	1.00	7.01	C	N
  ATOM	7795	CA	VAL	I	90	−9.124	−3.474	18.849	1.00	6.26	C	C
  ATOM	7796	CB	VAL	I	90	−9.079	−3.943	20.313	1.00	5.91	C	C
  ATOM	7797	CG1	VAL	I		90	−9.557	−5.381	20.422	1.00	5.92	C	C
  ATOM	7798	CG2	VAL	I		90	−7.671	−3.802	20.871	1.00	5.26	C	C
  ATOM	7799	C	VAL	I		90	−10.524	−3.689	18.299	1.00	6.25	C	C
  ATOM	7800	O	VAL	I	90	−10.765	−4.663	17.592	1.00	6.32	C	O
  ATOM	7801	N	THR	I	91	−11.445	−2.776	18.592	1.00	6.24	C	N
  ATOM	7802	CA	THR	I	91	−12.799	−2.932	18.065	1.00	6.68	C	C
  ATOM	7803	CB	THR	I	91	−13.734	−1.829	18.584	1.00	6.62	C	C
  ATOM	7804	OG1	THR	I	91	−13.711	−1.819	20.017	1.00	7.19	C	O
  ATOM	7805	CG2	THR	I	91	−15.157	−2.071	18.106	1.00	7.27	C	C
  ATOM	7806	C	THR	I	91	−12.768	−2.885	16.536	1.00	7.02	C	C
  ATOM	7807	O	THR	I	91	−13.430	−3.703	15.833	1.00	7.16	C	O
  ATOM	7808	N	GLU	I	92	−11.970	−1.955	16.011	1.00	7.31	C	N
  ATOM	7809	CA	GLU	I	92	−11.889	−1.863	14.558	1.00	7.81	C	C
  ATOM	7810	CB	GLU	I	92	−11.017	−0.680	14.131	1.00	8.23	C	C
  ATOM	7811	CG	GLU	I	92	−11.774	0.630	13.973	1.00	10.91	C	C
  ATOM	7812	CD	GLU	I	92	−12.907	0.529	12.969	1.00	14.95	C	C
  ATOM	7813	OE1	GLU	I	92	−12.739	1.010	11.830	1.00	16.14	C	O
  ATOM	7814	OE2	GLU	I	92	−13.968	−0.027	13.320	1.00	16.53	C	O
  ATOM	7815	C	GLU	I	92	−11.349	−3.164	13.959	1.00	7.47	C	C
  ATOM	7816	O	GLU	I	92	−11.911	−3.691	12.994	1.00	7.32	C	O
  ATOM	7817	N	LEU	I	93	−10.303	−3.716	14.568	1.00	7.30	C	N
  ATOM	7818	CA	LEU	I	93	−9.703	−4.950	14.062	1.00	7.47	C	C
  ATOM	7819	CB	LEU	I	93	−8.429	−5.299	14.830	1.00	7.15	C	C
  ATOM	7820	CG	LEU	I	93	−7.212	−4.438	14.490	1.00	7.20	C	C
  ATOM	7821	CD1	LEU	I	93	−5.977	−4.957	15.204	1.00	7.93	C	C
  ATOM	7822	CD2	LEU	I	93	−6.989	−4.392	12.984	1.00	6.91	C	C
  ATOM	7823	C	LEU	I	93	−10.705	−6.097	14.123	1.00	7.89	C	C
  ATOM	7824	O	LEU	I	93	−10.764	−6.947	13.235	1.00	7.94	C	O
  ATOM	7825	N	GLN	I	94	−11.486	−6.094	15.193	1.00	8.31	C	N
  ATOM	7826	CA	GLN	I	94	−12.514	−7.088	15.461	1.00	9.05	C	C
  ATOM	7827	CB	GLN	I	94	−13.131	−6.862	16.845	1.00	9.18	C	C
  ATOM	7828	CG	GLN	I	94	−12.158	−7.052	17.996	1.00	10.79	C	C
  ATOM	7829	CD	GLN	I	94	−12.831	−6.966	19.353	1.00	13.82	C	C
  ATOM	7830	OE1	GLN	I	94	−14.042	−6.762	19.448	1.00	14.98	C	O
  ATOM	7831	NE2	GLN	I	94	−12.047	−7.125	20.412	1.00	15.25	C	N
  ATOM	7832	C	GLN	I	94	−13.615	−7.127	14.405	1.00	9.25	C	C
  ATOM	7833	O	GLN	I	94	−14.122	−8.204	14.093	1.00	9.43	C	O
  ATOM	7834	N	LEU	I	95	−14.007	−5.977	13.858	1.00	9.55	C	N
  ATOM	7835	CA	LEU	I	95	−15.128	−6.009	12.888	1.00	10.17	C	C
  ATOM	7836	CB	LEU	I	95	−15.535	−4.582	12.510	1.00	9.79	C	C
  ATOM	7837	CG	LEU	I	95	−16.117	−3.716	13.628	1.00	8.86	C	C
  ATOM	7838	CD1	LEU	I	95	−16.419	−2.315	13.117	1.00	8.31	C	C
  ATOM	7839	CD2	LEU	I	95	−17.367	−4.359	14.211	1.00	7.62	C	C
  ATOM	7840	C	LEU	I	95	−14.958	−6.865	11.591	1.00	11.22	C	C
  ATOM	7841	O	LEU	I	95	−15.902	−7.505	11.125	1.00	11.55	C	O
  ATOM	7842	N	LEU	I	96	−13.751	−6.843	11.039	1.00	12.40	C	N
  ATOM	7843	CA	LEU	I	96	−13.313	−7.374	9.755	1.00	13.66	C	C
  ATOM	7844	CB	LEU	I	96	−11.796	−7.246	9.601	1.00	13.38	C	C
  ATOM	7845	CG	LEU	I	96	−11.288	−5.847	9.244	1.00	13.32	C	C
  ATOM	7846	CD1	LEU	I	96	−9.901	−5.910	8.624	1.00	12.84	C	C
  ATOM	7847	CD2	LEU	I	96	−12.256	−5.161	8.301	1.00	13.38	C	C
  ATOM	7848	C	LEU	I	96	−13.765	−8.817	9.534	1.00	14.97	C	C
  ATOM	7849	O	LEU	I	96	−13.908	−9.257	8.395	1.00	15.21	C	O
  ATOM	7850	N	MET	I	97	−14.125	−9.501	10.615	1.00	16.74	C	N
  ATOM	7851	CA	MET	I	97	−14.122	−10.962	10.625	1.00	18.96	C	C
  ATOM	7852	CB	MET	I	97	−13.987	−11.498	12.053	1.00	19.12	C	C
  ATOM	7853	CG	MET	I	97	−12.742	−11.021	12.784	1.00	21.87	C	C
  ATOM	7854	SD	MET	I	97	−11.220	−11.692	12.090	1.00	27.46	C	S
  ATOM	7855	CE	MET	I	97	−11.585	−11.630	10.338	1.00	24.25	C	C
  ATOM	7856	C	MET	I	97	−15.339	−11.576	9.929	1.00	20.09	C	C
  ATOM	7857	O	MET	I	97	−15.246	−12.655	9.343	1.00	20.58	C	O
  ATOM	7858	N	GLN	I	98	−16.462	−10.865	9.950	1.00	21.33	C	N
  ATOM	7859	CA	GLN	I	98	−17.706	−11.392	9.401	1.00	22.21	C	C
  ATOM	7860	CB	GLN	I	98	−18.708	−11.678	10.521	1.00	22.53	C	C
  ATOM	7861	CG	GLN	I	98	−18.099	−12.341	11.742	1.00	23.85	C	C
  ATOM	7862	CD	GLN	I	98	−17.673	−11.337	12.792	1.00	25.21	C	C
  ATOM	7863	OE1	GLN	I	98	−16.838	−10.469	12.535	1.00	24.47	C	O
  ATOM	7864	NE2	GLN	I	98	−18.199	−11.489	14.002	1.00	24.85	C	N
  ATOM	7865	C	GLN	I	98	−18.318	−10.439	8.378	1.00	22.15	C	C
  ATOM	7866	O	GLN	I	98	−17.765	−9.376	8.095	1.00	21.77	C	O
  ATOM	7867	N	PHE	I	137	−22.709	−16.921	4.271	1.00	33.25	C	N
  ATOM	7868	CA	PHE	I	137	−21.644	−16.142	3.651	1.00	36.79	C	C
  ATOM	7869	CB	PHE	I	137	−21.061	−16.892	2.453	1.00	20.00	C	C
  ATOM	7870	CG	PHE	I	137	−20.354	−18.166	2.825	1.00	20.00	C	C
  ATOM	7871	CD1	PHE	I	137	−19.059	−18.134	3.318	1.00	20.00	C	C
  ATOM	7872	CE1	PHE	I	137	−18.416	−19.301	3.700	1.00	20.00	C	C
  ATOM	7873	CZ	PHE	I	137	−19.092	−20.504	3.660	1.00	20.00	C	C
  ATOM	7874	CE2	PHE	I	137	−20.414	−20.534	3.260	1.00	20.00	C	C
  ATOM	7875	CD2	PHE	I	137	−21.046	−19.365	2.871	1.00	20.00	C	C
  ATOM	7876	C	PHE	I	137	−22.138	−14.765	3.226	1.00	48.73	C	C
  ATOM	7877	O	PHE	I	137	−21.342	−13.888	2.890	1.00	49.28	C	O
  ATOM	7878	N	LEU	I	138	−23.454	−14.580	3.253	1.00	42.04	C	N
  ATOM	7879	CA	LEU	I	138	−24.055	−13.275	2.999	1.00	44.26	C	C
  ATOM	7880	CB	LEU	I	138	−25.581	−13.366	3.047	1.00	20.00	C	C
  ATOM	7881	CG	LEU	I	138	−26.248	−14.219	1.966	1.00	20.00	C	C
  ATOM	7882	CD1	LEU	I	138	−27.748	−14.301	2.197	1.00	20.00	C	C
  ATOM	7883	CD2	LEU	I	138	−25.944	−13.673	0.580	1.00	20.00	C	C
  ATOM	7884	C	LEU	I	138	−23.565	−12.242	4.006	1.00	43.68	C	C
  ATOM	7885	O	LEU	I	138	−23.730	−11.038	3.804	1.00	50.27	C	O
  ATOM	7886	N	GLY	I	139	−22.983	−12.724	5.100	1.00	38.56	C	N
  ATOM	7887	CA	GLY	I	139	−22.415	−11.853	6.126	1.00	47.99	C	C
  ATOM	7888	C	GLY	I	139	−21.274	−10.985	5.625	1.00	44.53	C	C
  ATOM	7889	O	GLY	I	139	−20.971	−9.947	6.213	1.00	32.21	C	O
  ATOM	7890	N	PHE	I		140	−20.649	−11.402	4.528	1.00	46.33	C	N
  ATOM	7891	CA	PHE	I	140	−19.494	−10.693	3.986	1.00	42.95	C	C
  ATOM	7892	CB	PHE	I	140	−18.549	−11.668	3.281	1.00	20.00	C	C
  ATOM	7893	CG	PHE	I	140	−17.916	−12.677	4.202	1.00	20.00	C	C
  ATOM	7894	CD1	PHE	I	140	−16.781	−12.356	4.929	1.00	20.00	C	C
  ATOM	7895	CE1	PHE	I		140	−16.194	−13.284	5.769	1.00	20.00	C	C
  ATOM	7896	CZ	PHE	I	140	−16.731	−14.551	5.879	1.00	20.00	C	C
  ATOM	7897	CE2	PHE	I	140	−17.854	−14.888	5.150	1.00	20.00	C	C
  ATOM	7898	CD2	PHE	I		140	−18.434	−13.958	4.308	1.00	20.00	C	C
  ATOM	7899	C	PHE	I	140	−19.898	−9.568	3.032	1.00	38.13	C	C
  ATOM	7900	O	PHE	I	140	−19.052	−8.795	2.581	1.00	57.33	C	O
  ATOM	7901	N	LEU	I	141	−21.191	−9.475	2.736	1.00	35.20	C	N
  ATOM	7902	CA	LEU	I	141	−21.690	−8.512	1.759	1.00	27.01	C	C
  ATOM	7903	CB	LEU	I	141	−21.184	−7.103	2.079	1.00	20.00	C	C
  ATOM	7904	CG	LEU	I	141	−21.717	−6.450	3.356	1.00	20.00	C	C
  ATOM	7905	CD1	LEU	I	141	−20.991	−5.144	3.632	1.00	20.00	C	C
  ATOM	7906	CD2	LEU	I	141	−23.216	−6.216	3.252	1.00	20.00	C	C
  ATOM	7907	C	LEU	I	141	−21.292	−8.918	0.341	1.00	35.79	C	C
  ATOM	7908	O	LEU	I	141	−21.674	−9.989	−0.130	1.00	46.92	C	O
  ATOM	7909	N	LEU	I	142	−20.469	−8.099	−0.306	1.00	38.67	C	N
  ATOM	7910	CA	LEU	I	142	−19.832	−8.492	−1.559	1.00	33.84	C	C
  ATOM	7911	CB	LEU	I	142	−20.017	−7.408	−2.618	1.00	20.00	C	C
  ATOM	7912	CG	LEU	I	142	−21.465	−7.163	−3.040	1.00	20.00	C	C
  ATOM	7913	CD1	LEU	I	142	−21.584	−5.883	−3.848	1.00	20.00	C	C
  ATOM	7914	CD2	LEU	I	142	−21.999	−8.350	−3.827	1.00	20.00	C	C
  ATOM	7915	C	LEU	I	142	−18.352	−8.799	−1.363	1.00	36.89	C	C
  ATOM	7916	O	LEU	I	142	−17.604	−7.979	−0.831	1.00	45.42	C	O
  ATOM	7917	N	GLY	I	143	−17.970	−10.034	−1.673	1.00	26.84	C	N
  ATOM	7918	CA	GLY	I	143	−16.624	−10.516	−1.387	1.00	27.41	C	C
  ATOM	7919	C	GLY	I	143	−15.977	−11.154	−2.599	1.00	29.08	C	C
  ATOM	7920	O	GLY	I	143	−16.645	−11.813	−3.396	1.00	40.24	C	O
  ATOM	7921	N	VAL	I	144	−14.672	−10.957	−2.742	1.00	30.17	C	N
  ATOM	7922	CA	VAL	I	144	−13.928	−11.605	−3.814	1.00	34.15	C	C
  ATOM	7923	CB	VAL	I	144	−12.559	−10.921	−4.058	1.00	20.00	C	C
  ATOM	7924	CG1	VAL	I	144	−11.826	−11.591	−5.212	1.00	20.00	C	C
  ATOM	7925	CG2	VAL	I	144	−12.750	−9.434	−4.339	1.00	20.00	C	C
  ATOM	7926	C	VAL	I	144	−13.732	−13.091	−3.508	1.00	36.67	C	C
  ATOM	7927	O	VAL	I	144	−14.071	−13.558	−2.419	1.00	42.49	C	O
  ATOM	7928	N	GLY	I	145	−13.320	−13.847	−4.521	1.00	47.09	C	N
  ATOM	7929	CA	GLY	I	145	−12.893	−15.227	−4.321	1.00	44.51	C	C
  ATOM	7930	C	GLY	I	145	−11.950	−15.377	−3.141	1.00	44.94	C	C
  ATOM	7931	O	GLY	I	145	−12.181	−16.196	−2.253	1.00	40.58	C	O
  ATOM	7932	N	SER	I	146	−10.905	−14.560	−3.085	1.00	42.06	C	N
  ATOM	7933	CA	SER	I	146	−9.931	−14.673	−2.000	1.00	47.39	C	C
  ATOM	7934	CB	SER	I	146	−8.758	−13.718	−2.236	1.00	20.00	C	C
  ATOM	7935	OG	SER	I	146	−9.200	−12.373	−2.297	1.00	20.00	C	O
  ATOM	7936	C	SER	I	146	−10.535	−14.425	−0.613	1.00	51.48	C	C
  ATOM	7937	O	SER	I	146	−10.211	−15.129	0.351	1.00	47.45	C	O
  ATOM	7938	N	ALA	I	147	−11.415	−13.434	−0.514	1.00	39.51	C	N
  ATOM	7939	CA	ALA	I	147	−12.026	−13.082	0.766	1.00	43.38	C	C
  ATOM	7940	CB	ALA	I	147	−12.866	−11.821	0.621	1.00	20.00	C	C
  ATOM	7941	C	ALA	I	147	−12.865	−14.218	1.348	1.00	47.39	C	C
  ATOM	7942	O	ALA	I	147	−12.823	−14.476	2.554	1.00	50.18	C	O
  ATOM	7943	N	ILE	I	148	−13.624	−14.894	0.492	1.00	44.67	C	N
  ATOM	7944	CA	ILE	I	148	−14.453	−16.007	0.937	1.00	43.56	C	C
  ATOM	7945	CB	ILE	I	148	−15.322	−16.558	−0.208	1.00	20.00	C	C
  ATOM	7946	CG1	ILE	I	148	−16.249	−15.466	−0.746	1.00	20.00	C	C
  ATOM	7947	CD1	ILE	I	148	−17.141	−15.925	−1.878	1.00	20.00	C	C
  ATOM	7948	CG2	ILE	I	148	−16.127	−17.759	0.265	1.00	20.00	C	C
  ATOM	7949	C	ILE	I	148	−13.575	−17.126	1.483	1.00	51.18	C	C
  ATOM	7950	O	ILE	I	148	−13.886	−17.736	2.510	1.00	39.17	C	O
  ATOM	7951	N	ALA	I	149	−12.468	−17.382	0.794	1.00	42.17	C	N
  ATOM	7952	CA	ALA	I	149	−11.531	−18.412	1.217	1.00	36.76	C	C
  ATOM	7953	CB	ALA	I	149	−10.424	−18.578	0.189	1.00	20.00	C	C
  ATOM	7954	C	ALA	I	149	−10.949	−18.044	2.574	1.00	45.19	C	C
  ATOM	7955	O	ALA	I	149	−10.806	−18.897	3.451	1.00	47.83	C	O
  ATOM	7956	N	SER	I	150	−10.632	−16.765	2.748	1.00	43.64	C	N
  ATOM	7957	CA	SER	I	150	−10.084	−16.296	4.014	1.00	43.46	C	C
  ATOM	7958	CB	SER	I	150	−9.701	−14.818	3.919	1.00	20.00	C	C
  ATOM	7959	OG	SER	I	150	−10.828	−14.018	3.605	1.00	20.00	C	O
  ATOM	7960	C	SER	I	150	−11.093	−16.507	5.138	1.00	44.80	C	C
  ATOM	7961	O	SER	I	150	−10.733	−16.932	6.238	1.00	41.55	C	O
  ATOM	7962	N	GLY	I	151	−12.361	−16.222	4.854	1.00	27.01	C	N
  ATOM	7963	CA	GLY	I	151	−13.413	−16.410	5.836	1.00	35.21	C	C
  ATOM	7964	C	GLY	I	151	−13.553	−17.871	6.219	1.00	42.40	C	C
  ATOM	7965	O	GLY	I	151	−13.742	−18.212	7.394	1.00	45.11	C	O
  ATOM	7966	N	VAL	I	152	−13.454	−18.742	5.219	1.00	40.20	C	N
  ATOM	7967	CA	VAL	I	152	−13.548	−20.175	5.458	1.00	46.73	C	C
  ATOM	7968	CB	VAL	I	152	−13.505	−20.973	4.144	1.00	20.00	C	C
  ATOM	7969	CG1	VAL	I	152	−13.606	−22.464	4.426	1.00	20.00	C	C
  ATOM	7970	CG2	VAL	I	152	−14.621	−20.523	3.214	1.00	20.00	C	C
  ATOM	7971	C	VAL	I	152	−12.396	−20.615	6.351	1.00	48.62	C	C
  ATOM	7972	O	VAL	I	152	−12.579	−21.411	7.273	1.00	49.32	C	O
  ATOM	7973	N	ALA	I	153	−11.212	−20.074	6.083	1.00	35.09	C	N
  ATOM	7974	CA	ALA	I	153	−10.030	−20.403	6.867	1.00	42.37	C	C
  ATOM	7975	CB	ALA	I	153	−8.798	−19.741	6.274	1.00	20.00	C	C
  ATOM	7976	C	ALA	I	153	−10.231	−19.965	8.310	1.00	37.79	C	C
  ATOM	7977	O	ALA	I	153	−9.860	−20.676	9.244	1.00	39.25	C	O
  ATOM	7978	N	VAL	I	154	−10.825	−18.789	8.486	1.00	38.88	C	N
  ATOM	7979	CA	VAL	I	154	−11.100	−18.270	9.819	1.00	35.53	C	C
  ATOM	7980	CB	VAL	I	154	−11.680	−16.845	9.762	1.00	20.00	C	C
  ATOM	7981	CG1	VAL	I	154	−11.955	−16.328	11.165	1.00	20.00	C	C
  ATOM	7982	CG2	VAL	I	154	−10.731	−15.916	9.021	1.00	20.00	C	C
  ATOM	7983	C	VAL	I	154	−12.071	−19.175	10.572	1.00	41.00	C	C
  ATOM	7984	O	VAL	I	154	−11.884	−19.441	11.759	1.00	50.08	C	O
  ATOM	7985	N	SER	I	155	−13.105	−19.652	9.882	1.00	37.82	C	N
  ATOM	7986	CA	SER	I	155	−14.071	−20.556	10.508	1.00	44.68	C	C
  ATOM	7987	CB	SER	I	155	−15.239	−20.834	9.561	1.00	20.00	C	C
  ATOM	7988	OG	SER	I	155	−14.790	−21.436	8.360	1.00	20.00	C	O
  ATOM	7989	C	SER	I	155	−13.400	−21.867	10.917	1.00	41.82	C	C
  ATOM	7990	O	SER	I	155	−13.667	−22.425	11.982	1.00	49.37	C	O
  ATOM	7991	N	LYS	I	156	−12.525	−22.338	10.038	1.00	36.99	C	N
  ATOM	7992	CA	LYS	I	156	−11.772	−23.575	10.184	1.00	35.11	C	C
  ATOM	7993	CB	LYS	I	156	−11.122	−23.965	8.856	1.00	20.00	C	C
  ATOM	7994	CG	LYS	I	156	−12.116	−24.339	7.768	1.00	20.00	C	C
  ATOM	7995	CD	LYS	I	156	−11.408	−24.786	6.499	1.00	20.00	C	C
  ATOM	7996	CE	LYS	I	156	−12.400	−25.265	5.452	1.00	20.00	C	C
  ATOM	7997	NZ	LYS	I	156	−11.733	−25.581	4.158	1.00	20.00	C	N
  ATOM	7998	C	LYS	I	156	−10.715	−23.451	11.275	1.00	35.98	C	C
  ATOM	7999	O	LYS	I	156	−10.361	−24.436	11.922	1.00	42.31	C	O
  ATOM	8000	N	VAL	I	157	−10.260	−22.224	11.514	1.00	37.88	C	N
  ATOM	8001	CA	VAL	I	157	−9.225	−21.960	12.515	1.00	50.94	C	C
  ATOM	8002	CB	VAL	I	157	−8.267	−20.831	12.062	1.00	20.00	C	C
  ATOM	8003	CG1	VAL	I	157	−7.261	−20.505	13.162	1.00	20.00	C	C
  ATOM	8004	CG2	VAL	I	157	−7.552	−21.219	10.771	1.00	20.00	C	C
  ATOM	8005	C	VAL	I	157	−9.832	−21.596	13.871	1.00	47.82	C	C
  ATOM	8006	O	VAL	I	157	−9.116	−21.443	14.863	1.00	56.87	C	O
  ATOM	8007	N	LEU	I	158	−11.156	−21.533	13.947	1.00	39.52	C	N
  ATOM	8008	CA	LEU	I	158	−11.838	−20.969	15.112	1.00	50.27	C	C
  ATOM	8009	CB	LEU	I	158	−13.351	−20.935	14.869	1.00	20.00	C	C
  ATOM	8010	CG	LEU	I	158	−13.827	−20.109	13.673	1.00	20.00	C	C
  ATOM	8011	CD1	LEU	I	158	−15.343	−20.163	13.552	1.00	20.00	C	C
  ATOM	8012	CD2	LEU	I	158	−13.346	−18.671	13.788	1.00	20.00	C	C
  ATOM	8013	C	LEU	I	158	−11.550	−21.631	16.465	1.00	54.47	C	C
  ATOM	8014	O	LEU	I	158	−11.417	−20.934	17.477	1.00	49.26	C	O
  ATOM	8015	N	HIS	I	159	−11.447	−22.954	16.501	1.00	59.45	C	N
  ATOM	8016	CA	HIS	I	159	−11.205	−23.636	17.768	1.00	49.11	C	C
  ATOM	8017	CB	HIS	I	159	−11.225	−25.153	17.573	1.00	20.00	C	C
  ATOM	8018	CG	HIS	I	159	−12.522	−25.676	17.038	1.00	20.00	C	C
  ATOM	8019	ND1	HIS	I	159	−13.559	−26.070	17.855	1.00	20.00	C	N
  ATOM	8020	CE1	HIS	I	159	−14.570	−26.484	17.112	1.00	20.00	C	C
  ATOM	8021	NE2	HIS	I	159	−14.225	−26.373	15.842	1.00	20.00	C	N
  ATOM	8022	CD2	HIS	I	159	−12.949	−25.871	15.768	1.00	20.00	C	C
  ATOM	8023	C	HIS	I	159	−9.874	−23.203	18.385	1.00	44.09	C	C
  ATOM	8024	O	HIS	I	159	−9.780	−22.977	19.596	1.00	42.13	C	O
  ATOM	8025	N	LEU	I	160	−8.851	−23.072	17.546	1.00	37.55	C	N
  ATOM	8026	CA	LEU	I	160	−7.536	−22.649	18.011	1.00	43.52	C	C
  ATOM	8027	CB	LEU	I	160	−6.520	−22.704	16.869	1.00	20.00	C	C
  ATOM	8028	CG	LEU	I	160	−6.299	−24.073	16.224	1.00	20.00	C	C
  ATOM	8029	CD1	LEU	I	160	−5.268	−23.982	15.109	1.00	20.00	C	C
  ATOM	8030	CD2	LEU	I	160	−5.877	−25.097	17.266	1.00	20.00	C	C
  ATOM	8031	C	LEU	I	160	−7.599	−21.240	18.591	1.00	47.22	C	C
  ATOM	8032	O	LEU	I	160	−6.984	−20.951	19.619	1.00	43.25	C	O
  ATOM	8033	N	GLU	I	161	−8.351	−20.368	17.927	1.00	40.88	C	N
  ATOM	8034	CA	GLU	I	161	−8.512	−18.996	18.388	1.00	40.61	C	C
  ATOM	8035	CB	GLU	I	161	−9.325	−18.182	17.381	1.00	20.00	C	C
  ATOM	8036	CG	GLU	I	161	−8.702	−18.104	15.997	1.00	20.00	C	C
  ATOM	8037	CD	GLU	I	161	−9.537	−17.292	15.027	1.00	20.00	C	C
  ATOM	8038	OE1	GLU	I	161	−9.126	−17.158	13.855	1.00	20.00	C	O
  ATOM	8039	OE2	GLU	I	161	−10.604	−16.788	15.436	1.00	20.00	C	O
  ATOM	8040	C	GLU	I	161	−9.195	−18.983	19.749	1.00	39.76	C	C
  ATOM	8041	O	GLU	I	161	−8.816	−18.221	20.642	1.00	44.02	C	O
  ATOM	8042	N	GLY	I	162	−10.199	−19.840	19.906	1.00	34.18	C	N
  ATOM	8043	CA	GLY	I	162	−10.907	−19.934	21.169	1.00	35.01	C	C
  ATOM	8044	C	GLY	I	162	−9.967	−20.387	22.269	1.00	34.86	C	C
  ATOM	8045	O	GLY	I	162	−9.997	−19.864	23.386	1.00	47.81	C	O
  ATOM	8046	N	GLU	I	163	−9.112	−21.352	21.945	1.00	40.78	C	N
  ATOM	8047	CA	GLU	I	163	−8.143	−21.856	22.911	1.00	37.20	C	C
  ATOM	8048	CB	GLU	I	163	−7.365	−23.036	22.326	1.00	20.00	C	C
  ATOM	8049	CG	GLU	I	163	−8.235	−24.218	21.931	1.00	20.00	C	C
  ATOM	8050	CD	GLU	I	163	−7.430	−25.368	21.357	1.00	20.00	C	C
  ATOM	8051	OE1	GLU	I	163	−8.037	−26.397	20.995	1.00	20.00	C	O
  ATOM	8052	OE2	GLU	I	163	−6.191	−25.241	21.268	1.00	20.00	C	O
  ATOM	8053	C	GLU	I	163	−7.183	−20.745	23.324	1.00	46.12	C	C
  ATOM	8054	O	GLU	I	163	−6.837	−20.611	24.501	1.00	58.66	C	O
  ATOM	8055	N	VAL	I	164	−6.761	−19.944	22.350	1.00	42.23	C	N
  ATOM	8056	CA	VAL	I	164	−5.857	−18.834	22.620	1.00	35.45	C	C
  ATOM	8057	CB	VAL	I	164	−5.429	−18.124	21.323	1.00	20.00	C	C
  ATOM	8058	CG1	VAL	I	164	−4.487	−16.971	21.635	1.00	20.00	C	C
  ATOM	8059	CG2	VAL	I	164	−4.775	−19.112	20.369	1.00	20.00	C	C
  ATOM	8060	C	VAL	I	164	−6.522	−17.823	23.548	1.00	46.32	C	C
  ATOM	8061	O	VAL	I	164	−5.892	−17.301	24.472	1.00	45.08	C	O
  ATOM	8062	N	ASN	I	165	−7.802	−17.558	23.304	1.00	40.82	C	N
  ATOM	8063	CA	ASN	I	165	−8.548	−16.631	24.144	1.00	46.48	C	C
  ATOM	8064	CB	ASN	I	165	−9.952	−16.403	23.581	1.00	20.00	C	C
  ATOM	8065	CG	ASN	I	165	−9.930	−15.822	22.181	1.00	20.00	C	C
  ATOM	8066	OD1	ASN	I	165	−10.975	−15.504	21.612	1.00	20.00	C	O
  ATOM	8067	ND2	ASN	I	165	−8.736	−15.681	21.617	1.00	20.00	C	N
  ATOM	8068	C	ASN	I	165	−8.631	−17.160	25.569	1.00	50.90	C	C
  ATOM	8069	O	ASN	I	165	−8.474	−16.412	26.536	1.00	47.11	C	O
  ATOM	8070	N	LYS	I	166	−8.857	−18.464	25.688	1.00	48.36	C	N
  ATOM	8071	CA	LYS	I	166	−8.945	−19.120	26.986	1.00	38.71	C	C
  ATOM	8072	CB	LYS	I	166	−9.329	−20.592	26.818	1.00	20.00	C	C
  ATOM	8073	CG	LYS	I	166	−10.649	−20.811	26.097	1.00	20.00	C	C
  ATOM	8074	CD	LYS	I	166	−10.952	−22.292	25.936	1.00	20.00	C	C
  ATOM	8075	CE	LYS	I	166	−12.264	−22.511	25.200	1.00	20.00	C	C
  ATOM	8076	NZ	LYS	I	166	−12.569	−23.958	25.028	1.00	20.00	C	N
  ATOM	8077	C	LYS	I	166	−7.623	−19.006	27.738	1.00	45.07	C	C
  ATOM	8078	O	LYS	I	166	−7.600	−18.823	28.955	1.00	56.09	C	O
  ATOM	8079	N	ILE	I	167	−6.525	−19.121	26.999	1.00	42.02	C	N
  ATOM	8080	CA	ILE	I	167	−5.184	−19.080	27.576	1.00	43.86	C	C
  ATOM	8081	CB	ILE	I	167	−4.207	−19.975	26.789	1.00	20.00	C	C
  ATOM	8082	CG1	ILE	I	167	−4.685	−21.429	26.804	1.00	20.00	C	C
  ATOM	8083	CD1	ILE	I	167	−3.778	−22.377	26.050	1.00	20.00	C	C
  ATOM	8084	CG2	ILE	I	167	−2.803	−19.865	27.362	1.00	20.00	C	C
  ATOM	8085	C	ILE	I	167	−4.599	−17.669	27.665	1.00	49.02	C	C
  ATOM	8086	O	ILE	I	167	−3.448	−17.497	28.066	1.00	37.71	C	O
  ATOM	8087	N	LYS	I	168	−5.382	−16.664	27.282	1.00	33.87	C	N
  ATOM	8088	CA	LYS	I	168	−4.890	−15.285	27.251	1.00	35.11	C	C
  ATOM	8089	CB	LYS	I	168	−5.939	−14.363	26.622	1.00	20.00	C	C
  ATOM	8090	CG	LYS	I	168	−6.275	−14.698	25.178	1.00	20.00	C	C
  ATOM	8091	CD	LYS	I	168	−7.292	−13.723	24.607	1.00	20.00	C	C
  ATOM	8092	CE	LYS	I	168	−7.612	−14.046	23.157	1.00	20.00	C	C
  ATOM	8093	NZ	LYS	I	168	−8.599	−13.092	22.580	1.00	20.00	C	N
  ATOM	8094	C	LYS	I	168	−4.431	−14.704	28.600	1.00	39.27	C	C
  ATOM	8095	O	LYS	I	168	−3.414	−14.012	28.655	1.00	32.39	C	O
  ATOM	8096	N	SER	I	169	−5.164	−14.973	29.677	1.00	41.30	C	N
  ATOM	8097	CA	SER	I	169	−4.797	−14.446	30.987	1.00	43.23	C	C
  ATOM	8098	CB	SER	I	169	−5.756	−14.957	32.064	1.00	20.00	C	C
  ATOM	8099	OG	SER	I	169	−5.739	−16.371	32.127	1.00	20.00	C	O
  ATOM	8100	C	SER	I	169	−3.359	−14.795	31.353	1.00	41.44	C	C
  ATOM	8101	O	SER	I	169	−2.580	−13.924	31.740	1.00	44.82	C	O
  ATOM	8102	N	ALA	I	170	−3.013	−16.072	31.235	1.00	39.78	C	N
  ATOM	8103	CA	ALA	I	170	−1.644	−16.517	31.469	1.00	41.01	C	C
  ATOM	8104	CB	ALA	I	170	−1.541	−18.025	31.320	1.00	20.00	C	C
  ATOM	8105	C	ALA	I	170	−0.674	−15.820	30.523	1.00	46.04	C	C
  ATOM	8106	O	ALA	I	170	0.396	−15.373	30.935	1.00	46.67	C	O
  ATOM	8107	N	LEU	I	171	−1.061	−15.718	29.258	1.00	34.26	C	N
  ATOM	8108	CA	LEU	I	171	−0.245	−15.030	28.269	1.00	37.69	C	C
  ATOM	8109	CB	LEU	I	171	−0.942	−15.036	26.912	1.00	20.00	C	C
  ATOM	8110	CG	LEU	I	171	−1.226	−16.424	26.346	1.00	20.00	C	C
  ATOM	8111	CD1	LEU	I	171	−1.873	−16.311	24.972	1.00	20.00	C	C
  ATOM	8112	CD2	LEU	I	171	0.060	−17.242	26.293	1.00	20.00	C	C
  ATOM	8113	C	LEU	I	171	0.053	−13.598	28.702	1.00	44.67	C	C
  ATOM	8114	O	LEU	I	171	1.173	−13.109	28.538	1.00	34.27	C	O
  ATOM	8115	N	LEU	I	172	−0.935	−12.955	29.314	1.00	34.80	C	N
  ATOM	8116	CA	LEU	I	172	−0.817	−11.555	29.692	1.00	28.87	C	C
  ATOM	8117	CB	LEU	I	172	−2.199	−10.971	29.993	1.00	20.00	C	C
  ATOM	8118	CG	LEU	I	172	−3.198	−10.968	28.835	1.00	20.00	C	C
  ATOM	8119	CD1	LEU	I	172	−4.534	−10.393	29.283	1.00	20.00	C	C
  ATOM	8120	CD2	LEU	I	172	−2.643	−10.187	27.668	1.00	20.00	C	C
  ATOM	8121	C	LEU	I	172	0.099	−11.400	30.901	1.00	29.90	C	C
  ATOM	8122	O	LEU	I	172	0.896	−10.462	30.972	1.00	41.09	C	O
  ATOM	8123	N	SER	I	173	0.016	−12.355	31.824	1.00	35.08	C	N
  ATOM	8124	CA	SER	I	173	0.740	−12.276	33.092	1.00	35.53	C	C
  ATOM	8125	CB	SER	I	173	0.110	−13.206	34.132	1.00	20.00	C	C
  ATOM	8126	OG	SER	I	173	0.148	−14.555	33.701	1.00	20.00	C	O
  ATOM	8127	C	SER	I	173	2.218	−12.610	32.919	1.00	35.07	C	C
  ATOM	8128	O	SER	I	173	3.042	−12.300	33.779	1.00	51.28	C	O
  ATOM	8129	N	THR	I	174	2.537	−13.275	31.817	1.00	46.35	C	N
  ATOM	8130	CA	THR	I	174	3.894	−13.733	31.561	1.00	43.83	C	C
  ATOM	8131	CB	THR	I	174	3.889	−14.970	30.641	1.00	20.00	C	C
  ATOM	8132	OG1	THR	I	174	3.327	−14.620	29.371	1.00	20.00	C	O
  ATOM	8133	CG2	THR	I	174	3.056	−16.081	31.260	1.00	20.00	C	C
  ATOM	8134	C	THR	I	174	4.722	−12.626	30.910	1.00	52.54	C	C
  ATOM	8135	O	THR	I	174	4.393	−12.154	29.821	1.00	64.10	C	O
  ATOM	8136	N	ASN	I	175	5.771	−12.188	31.599	1.00	55.57	C	N
  ATOM	8137	CA	ASN	I	175	6.735	−11.267	31.008	1.00	40.58	C	C
  ATOM	8138	CB	ASN	I	175	7.507	−10.521	32.099	1.00	20.00	C	C
  ATOM	8139	CG	ASN	I	175	6.646	−9.518	32.845	1.00	20.00	C	C
  ATOM	8140	OD1	ASN	I	175	5.640	−9.033	32.324	1.00	20.00	C	O
  ATOM	8141	ND2	ASN	I	175	7.043	−9.196	34.072	1.00	20.00	C	N
  ATOM	8142	C	ASN	I	175	7.708	−11.986	30.075	1.00	43.65	C	C
  ATOM	8143	O	ASN	I	175	8.525	−12.793	30.521	1.00	53.11	C	O
  ATOM	8144	N	LYS	I	176	7.546	−11.768	28.773	1.00	44.89	C	N
  ATOM	8145	CA	LYS	I	176	8.402	−12.407	27.776	1.00	46.42	C	C
  ATOM	8146	CB	LYS	I	176	8.150	−13.917	27.740	1.00	20.00	C	C
  ATOM	8147	CG	LYS	I	176	8.510	−14.625	29.034	1.00	20.00	C	C
  ATOM	8148	CD	LYS	I	176	8.270	−16.122	28.943	1.00	20.00	C	C
  ATOM	8149	CE	LYS	I	176	8.994	−16.863	30.063	1.00	20.00	C	C
  ATOM	8150	NZ	LYS	I	176	9.447	−18.223	29.648	1.00	20.00	C	N
  ATOM	8151	C	LYS	I	176	8.192	−11.798	26.392	1.00	45.00	C	C
  ATOM	8152	O	LYS	I	176	7.084	−11.379	26.053	1.00	60.64	C	O
  ATOM	8153	N	ALA	I	177	9.280	−11.645	25.643	1.00	46.01	C	N
  ATOM	8154	CA	ALA	I	177	9.189	−11.237	24.242	1.00	43.65	C	C
  ATOM	8155	CB	ALA	I	177	10.555	−10.847	23.706	1.00	20.00	C	C
  ATOM	8156	C	ALA	I	177	8.592	−12.349	23.395	1.00	41.42	C	C
  ATOM	8157	O	ALA	I	177	7.695	−12.116	22.584	1.00	45.37	C	O
  ATOM	8158	N	VAL	I	178	9.140	−13.549	23.545	1.00	35.70	C	N
  ATOM	8159	CA	VAL	I	178	8.580	−14.725	22.902	1.00	43.93	C	C
  ATOM	8160	CB	VAL	I	178	9.495	−15.243	21.780	1.00	20.00	C	C
  ATOM	8161	CG1	VAL	I	178	8.898	−16.490	21.143	1.00	20.00	C	C
  ATOM	8162	CG2	VAL	I	178	9.714	−14.159	20.734	1.00	20.00	C	C
  ATOM	8163	C	VAL	I	178	8.363	−15.829	23.922	1.00	34.16	C	C
  ATOM	8164	O	VAL	I	178	9.115	−15.950	24.889	1.00	44.45	C	O
  ATOM	8165	N	VAL	I	179	7.271	−16.565	23.760	1.00	44.87	C	N
  ATOM	8166	CA	VAL	I	179	6.916	−17.608	24.708	1.00	38.47	C	C
  ATOM	8167	CB	VAL	I	179	6.234	−17.027	25.960	1.00	20.00	C	C
  ATOM	8168	CG1	VAL	I	179	5.785	−18.147	26.887	1.00	20.00	C	C
  ATOM	8169	CG2	VAL	I	179	7.174	−16.076	26.680	1.00	20.00	C	C
  ATOM	8170	C	VAL	I	179	6.003	−18.648	24.074	1.00	44.79	C	C
  ATOM	8171	O	VAL	I	179	5.097	−18.317	23.310	1.00	51.88	C	O
  ATOM	8172	N	SER	I	180	6.270	−19.911	24.378	1.00	45.23	C	N
  ATOM	8173	CA	SER	I	180	5.428	−21.002	23.914	1.00	48.99	C	C
  ATOM	8174	CB	SER	I	180	6.171	−22.334	24.038	1.00	20.00	C	C
  ATOM	8175	OG	SER	I	180	6.627	−22.542	25.364	1.00	20.00	C	O
  ATOM	8176	C	SER	I	180	4.118	−21.053	24.698	1.00	48.15	C	C
  ATOM	8177	O	SER	I	180	4.116	−21.309	25.901	1.00	60.42	C	O
  ATOM	8178	N	LEU	I	181	3.009	−20.782	24.016	1.00	42.42	C	N
  ATOM	8179	CA	LEU	I	181	1.684	−20.959	24.605	1.00	43.22	C	C
  ATOM	8180	CB	LEU	I	181	0.610	−20.369	23.693	1.00	20.00	C	C
  ATOM	8181	CG	LEU	I	181	0.738	−18.866	23.467	1.00	20.00	C	C
  ATOM	8182	CD1	LEU	I	181	−0.514	−18.314	22.808	1.00	20.00	C	C
  ATOM	8183	CD2	LEU	I	181	1.008	−18.184	24.795	1.00	20.00	C	C
  ATOM	8184	C	LEU	I	181	1.388	−22.428	24.863	1.00	29.14	C	C
  ATOM	8185	O	LEU	I	181	1.144	−23.194	23.931	1.00	43.42	C	O
  ATOM	8186	N	SER	I	182	1.361	−22.807	26.136	1.00	41.83	C	N
  ATOM	8187	CA	SER	I	182	1.272	−24.214	26.503	1.00	53.52	C	C
  ATOM	8188	CB	SER	I	182	2.491	−24.642	27.324	1.00	20.00	C	C
  ATOM	8189	OG	SER	I	182	2.601	−23.890	28.521	1.00	20.00	C	O
  ATOM	8190	C	SER	I	182	−0.025	−24.557	27.236	1.00	44.76	C	C
  ATOM	8191	O	SER	I	182	−0.492	−23.802	28.090	1.00	37.73	C	O
  ATOM	8192	N	ASN	I	183	−0.652	−25.649	26.815	1.00	47.84	C	N
  ATOM	8193	CA	ASN	I	183	−1.684	−26.308	27.603	1.00	59.45	C	C
  ATOM	8194	CB	ASN	I	183	−3.002	−26.334	26.822	1.00	20.00	C	C
  ATOM	8195	CG	ASN	I	183	−3.598	−24.951	26.632	1.00	20.00	C	C
  ATOM	8196	OD1	ASN	I	183	−3.426	−24.069	27.473	1.00	20.00	C	O
  ATOM	8197	ND2	ASN	I	183	−4.381	−24.785	25.572	1.00	20.00	C	N
  ATOM	8198	C	ASN	I	183	−1.232	−27.732	27.905	1.00	75.41	C	C
  ATOM	8199	O	ASN	I	183	−0.535	−28.342	27.096	1.00	102.31	C	O
  ATOM	8200	N	GLY	I	184	−1.489	−28.200	29.121	1.00	79.30	C	N
  ATOM	8201	CA	GLY	I	184	−1.001	−29.510	29.549	1.00	88.92	C	C
  ATOM	8202	C	GLY	I	184	−0.204	−30.239	28.479	1.00	101.85	C	C
  ATOM	8203	O	GLY	I	184	−0.764	−30.990	27.680	1.00	113.48	C	O
  ATOM	8204	N	VAL	I	185	1.103	−29.994	28.448	1.00	86.84	C	N
  ATOM	8205	CA	VAL	I	185	2.047	−30.825	27.696	1.00	81.80	C	C
  ATOM	8206	CB	VAL	I	185	1.899	−32.323	28.027	1.00	20.00	C	C
  ATOM	8207	CG1	VAL	I	185	2.803	−33.155	27.126	1.00	20.00	C	C
  ATOM	8208	CG2	VAL	I	185	2.219	−32.578	29.491	1.00	20.00	C	C
  ATOM	8209	C	VAL	I	185	1.997	−30.638	26.179	1.00	81.69	C	C
  ATOM	8210	O	VAL	I	185	2.634	−31.388	25.439	1.00	99.84	C	O
  ATOM	8211	N	SER	I	186	1.282	−29.618	25.718	1.00	70.63	C	N
  ATOM	8212	CA	SER	I	186	1.132	−29.398	24.284	1.00	72.29	C	C
  ATOM	8213	CB	SER	I	186	−0.201	−29.962	23.792	1.00	20.00	C	C
  ATOM	8214	OG	SER	I	186	−1.291	−29.357	24.467	1.00	20.00	C	O
  ATOM	8215	C	SER	I	186	1.247	−27.923	23.915	1.00	62.99	C	C
  ATOM	8216	O	SER	I	186	0.649	−27.064	24.565	1.00	58.35	C	O
  ATOM	8217	N	VAL	I	187	2.013	−27.638	22.865	1.00	66.49	C	N
  ATOM	8218	CA	VAL	I	187	2.203	−26.266	22.398	1.00	57.36	C	C
  ATOM	8219	CB	VAL	I	187	3.581	−26.078	21.735	1.00	20.00	C	C
  ATOM	8220	CG1	VAL	I	187	3.748	−24.643	21.256	1.00	20.00	C	C
  ATOM	8221	CG2	VAL	I	187	4.691	−26.452	22.699	1.00	20.00	C	C
  ATOM	8222	C	VAL	I	187	1.116	−25.863	21.405	1.00	53.67	C	C
  ATOM	8223	O	VAL	I	187	0.949	−26.501	20.365	1.00	50.10	C	O
  ATOM	8224	N	LEU	I	188	0.381	−24.803	21.731	1.00	43.20	C	N
  ATOM	8225	CA	LEU	I	188	−0.676	−24.302	20.858	1.00	41.76	C	C
  ATOM	8226	CB	LEU	I	188	−1.749	−23.580	21.674	1.00	20.00	C	C
  ATOM	8227	CG	LEU	I	188	−2.557	−24.455	22.632	1.00	20.00	C	C
  ATOM	8228	CD1	LEU	I	188	−3.533	−23.609	23.429	1.00	20.00	C	C
  ATOM	8229	CD2	LEU	I	188	−3.287	−25.542	21.865	1.00	20.00	C	C
  ATOM	8230	C	LEU	I	188	−0.102	−23.361	19.813	1.00	44.75	C	C
  ATOM	8231	O	LEU	I	188	−0.674	−23.184	18.738	1.00	45.28	C	O
  ATOM	8232	N	THR	I	189	1.054	−22.786	20.124	1.00	39.28	C	N
  ATOM	8233	CA	THR	I	189	1.675	−21.805	19.250	1.00	36.51	C	C
  ATOM	8234	CB	THR	I	189	0.614	−20.957	18.526	1.00	20.00	C	C
  ATOM	8235	OG1	THR	I	189	−0.113	−20.177	19.481	1.00	20.00	C	O
  ATOM	8236	CG2	THR	I	189	−0.360	−21.858	17.785	1.00	20.00	C	C
  ATOM	8237	C	THR	I	189	2.615	−20.901	20.039	1.00	45.83	C	C
  ATOM	8238	O	THR	I	189	3.150	−21.304	21.072	1.00	42.57	C	O
  ATOM	8239	N	SER	I	190	2.853	−19.698	19.530	1.00	40.44	C	N
  ATOM	8240	CA	SER	I	190	3.792	−18.785	20.166	1.00	41.82	C	C
  ATOM	8241	CB	SER	I	190	5.022	−18.584	19.283	1.00	20.00	C	C
  ATOM	8242	OG	SER	I	190	4.664	−18.015	18.038	1.00	20.00	C	O
  ATOM	8243	C	SER	I	190	3.146	−17.444	20.491	1.00	33.81	C	C
  ATOM	8244	O	SER	I	190	2.391	−16.897	19.687	1.00	49.61	C	O
  ATOM	8245	N	LYS	I	191	3.454	−16.920	21.674	1.00	37.37	C	N
  ATOM	8246	CA	LYS	I	191	2.986	−15.598	22.086	1.00	41.23	C	C
  ATOM	8247	CB	LYS	I	191	2.358	−15.664	23.478	1.00	20.00	C	C
  ATOM	8248	CG	LYS	I	191	1.069	−16.459	23.525	1.00	20.00	C	C
  ATOM	8249	CD	LYS	I	191	0.505	−16.514	24.931	1.00	20.00	C	C
  ATOM	8250	CE	LYS	I	191	−0.626	−17.531	25.037	1.00	20.00	C	C
  ATOM	8251	NZ	LYS	I	191	−0.791	−18.032	26.435	1.00	20.00	C	N
  ATOM	8252	C	LYS	I		191	4.112	−14.568	22.069	1.00	35.03	C	C
  ATOM	8253	O	LYS	I	191	5.120	−14.728	22.757	1.00	40.06	C	O
  ATOM	8254	N	VAL	I	192	3.920	−13.495	21.308	1.00	33.70	C	N
  ATOM	8255	CA	VAL	I	192	4.967	−12.498	21.120	1.00	27.61	C	C
  ATOM	8256	CB	VAL	I	192	5.392	−12.392	19.646	1.00	20.00	C	C
  ATOM	8257	CG1	VAL	I	192	6.395	−11.267	19.465	1.00	20.00	C	C
  ATOM	8258	CG2	VAL	I	192	5.972	−13.709	19.165	1.00	20.00	C	C
  ATOM	8259	C	VAL	I	192	4.550	−11.121	21.624	1.00	31.74	C	C
  ATOM	8260	O	VAL	I	192	3.376	−10.755	21.573	1.00	25.58	C	O
  ATOM	8261	N	LEU	I	193	5.526	−10.364	22.114	1.00	28.88	C	N
  ATOM	8262	CA	LEU	I	193	5.316	−8.973	22.488	1.00	34.36	C	C
  ATOM	8263	CB	LEU	I	193	5.118	−8.855	23.998	1.00	20.00	C	C
  ATOM	8264	CG	LEU	I	193	3.893	−9.566	24.567	1.00	20.00	C	C
  ATOM	8265	CD1	LEU	I	193	3.915	−9.514	26.084	1.00	20.00	C	C
  ATOM	8266	CD2	LEU	I	193	2.623	−8.947	24.019	1.00	20.00	C	C
  ATOM	8267	C	LEU	I	193	6.507	−8.126	22.059	1.00	33.03	C	C
  ATOM	8268	O	LEU	I	193	7.592	−8.238	22.627	1.00	44.93	C	O
  ATOM	8269	N	ASP	I	194	6.304	−7.294	21.042	1.00	35.09	C	N
  ATOM	8270	CA	ASP	I	194	7.409	−6.702	20.288	1.00	41.39	C	C
  ATOM	8271	CB	ASP	I	194	6.892	−6.027	19.014	1.00	20.00	C	C
  ATOM	8272	CG	ASP	I	194	6.375	−7.023	17.994	1.00	20.00	C	C
  ATOM	8273	OD1	ASP	I	194	6.659	−8.229	18.141	1.00	20.00	C	O
  ATOM	8274	OD2	ASP	I	194	5.654	−6.606	17.064	1.00	20.00	C	O
  ATOM	8275	C	ASP	I	194	8.255	−5.712	21.094	1.00	38.04	C	C
  ATOM	8276	O	ASP	I	194	9.349	−5.339	20.670	1.00	48.03	C	O
  ATOM	8277	N	LEU	I	195	7.723	−5.232	22.215	1.00	43.64	C	N
  ATOM	8278	CA	LEU	I	195	8.360	−4.139	22.947	1.00	35.97	C	C
  ATOM	8279	CB	LEU	I	195	7.417	−2.935	23.045	1.00	20.00	C	C
  ATOM	8280	CG	LEU	I	195	7.024	−2.281	21.714	1.00	20.00	C	C
  ATOM	8281	CD1	LEU	I	195	5.965	−1.195	21.915	1.00	20.00	C	C
  ATOM	8282	CD2	LEU	I	195	8.249	−1.730	20.980	1.00	20.00	C	C
  ATOM	8283	C	LEU	I	195	8.858	−4.546	24.335	1.00	43.63	C	C
  ATOM	8284	O	LEU	I	195	9.609	−3.811	24.972	1.00	34.71	C	O
  ATOM	8285	N	ASN	I	196	8.535	−5.769	24.742	1.00	44.30	C	N
  ATOM	8286	CA	ASN	I	196	8.824	−6.238	26.095	1.00	42.38	C	C
  ATOM	8287	CB	ASN	I	196	8.399	−7.701	26.254	1.00	20.00	C	C
  ATOM	8288	CG	ASN	I	196	6.892	−7.874	26.221	1.00	20.00	C	C
  ATOM	8289	OD1	ASN	I	196	6.146	−6.952	26.545	1.00	20.00	C	O
  ATOM	8290	ND2	ASN	I	196	6.438	−9.055	25.817	1.00	20.00	C	N
  ATOM	8291	C	ASN	I	196	10.282	−6.058	26.511	1.00	43.66	C	C
  ATOM	8292	O	ASN	I	196	10.568	−5.610	27.622	1.00	33.62	C	O
  ATOM	8293	N	ASN	I	197	11.199	−6.448	25.633	1.00	34.31	C	N
  ATOM	8294	CA	ASN	I	197	12.621	−6.414	25.950	1.00	38.83	C	C
  ATOM	8295	CB	ASN	I	197	13.437	−7.021	24.812	1.00	20.00	C	C
  ATOM	8296	CG	ASN	I	197	13.306	−8.527	24.747	1.00	20.00	C	C
  ATOM	8297	OD1	ASN	I	197	13.064	−9.180	25.764	1.00	20.00	C	O
  ATOM	8298	ND2	ASN	I	197	13.315	−9.069	23.533	1.00	20.00	C	N
  ATOM	8299	C	ASN	I	197	13.106	−5.005	26.239	1.00	39.90	C	C
  ATOM	8300	O	ASN	I	197	13.745	−4.752	27.261	1.00	39.04	C	O
  ATOM	8301	N	TYR	I	198	12.824	−4.095	25.314	1.00	35.09	C	N
  ATOM	8302	CA	TYR	I	198	13.109	−2.682	25.518	1.00	41.03	C	C
  ATOM	8303	CB	TYR	I	198	12.610	−1.859	24.332	1.00	20.00	C	C
  ATOM	8304	CG	TYR	I	198	13.298	−2.189	23.031	1.00	20.00	C	C
  ATOM	8305	CD1	TYR	I	198	14.497	−1.579	22.687	1.00	20.00	C	C
  ATOM	8306	CE1	TYR	I	198	15.110	−1.847	21.488	1.00	20.00	C	C
  ATOM	8307	CZ	TYR	I	198	14.536	−2.752	20.620	1.00	20.00	C	C
  ATOM	8308	OH	TYR	I	198	15.138	−3.016	19.411	1.00	20.00	C	O
  ATOM	8309	CE2	TYR	I	198	13.349	−3.378	20.941	1.00	20.00	C	C
  ATOM	8310	CD2	TYR	I	198	12.749	−3.109	22.148	1.00	20.00	C	C
  ATOM	8311	C	TYR	I	198	12.490	−2.163	26.811	1.00	43.65	C	C
  ATOM	8312	O	TYR	I	198	13.128	−1.410	27.549	1.00	52.37	C	O
  ATOM	8313	N	ILE	I	199	11.279	−2.622	27.115	1.00	35.86	C	N
  ATOM	8314	CA	ILE	I	199	10.573	−2.185	28.316	1.00	45.39	C	C
  ATOM	8315	CB	ILE	I	199	9.108	−2.624	28.306	1.00	20.00	C	C
  ATOM	8316	CG1	ILE	I	199	8.330	−1.808	27.272	1.00	20.00	C	C
  ATOM	8317	CD1	ILE	I	199	7.307	−2.607	26.505	1.00	20.00	C	C
  ATOM	8318	CG2	ILE	I	199	8.502	−2.461	29.691	1.00	20.00	C	C
  ATOM	8319	C	ILE	I	199	11.232	−2.684	29.595	1.00	37.89	C	C
  ATOM	8320	O	ILE	I	199	11.344	−1.943	30.572	1.00	45.28	C	O
  ATOM	8321	N	ASP	I	200	11.628	−3.953	29.597	1.00	37.36	C	N
  ATOM	8322	CA	ASP	I	200	12.325	−4.543	30.737	1.00	46.66	C	C
  ATOM	8323	CB	ASP	I	200	12.549	−6.040	30.507	1.00	20.00	C	C
  ATOM	8324	CG	ASP	I	200	11.269	−6.841	30.616	1.00	20.00	C	C
  ATOM	8325	OD1	ASP	I	200	10.283	−6.314	31.172	1.00	20.00	C	O
  ATOM	8326	OD2	ASP	I	200	11.248	−7.996	30.143	1.00	20.00	C	O
  ATOM	8327	C	ASP	I	200	13.655	−3.842	31.033	1.00	51.05	C	C
  ATOM	8328	O	ASP	I	200	14.077	−3.753	32.188	1.00	57.39	C	O
  ATOM	8329	N	LYS	I	201	14.284	−3.306	29.989	1.00	57.68	C	N
  ATOM	8330	CA	LYS	I	201	15.560	−2.605	30.126	1.00	44.02	C	C
  ATOM	8331	CB	LYS	I	201	16.228	−2.417	28.760	1.00	20.00	C	C
  ATOM	8332	CG	LYS	I	201	16.590	−3.716	28.055	1.00	20.00	C	C
  ATOM	8333	CD	LYS	I	201	17.363	−3.463	26.764	1.00	20.00	C	C
  ATOM	8334	CE	LYS	I	201	17.644	−4.764	26.018	1.00	20.00	C	C
  ATOM	8335	NZ	LYS	I	201	18.195	−4.531	24.654	1.00	20.00	C	N
  ATOM	8336	C	LYS	I	201	15.409	−1.254	30.827	1.00	43.56	C	C
  ATOM	8337	O	LYS	I	201	16.366	−0.743	31.407	1.00	51.34	C	O
  ATOM	8338	N	GLN	I	202	14.202	−0.694	30.795	1.00	46.06	C	N
  ATOM	8339	CA	GLN	I	202	13.987	0.689	31.223	1.00	44.95	C	C
  ATOM	8340	CB	GLN	I	202	13.366	1.518	30.101	1.00	20.00	C	C
  ATOM	8341	CG	GLN	I	202	14.344	1.932	29.024	1.00	20.00	C	C
  ATOM	8342	CD	GLN	I	202	13.660	2.551	27.823	1.00	20.00	C	C
  ATOM	8343	OE1	GLN	I	202	12.435	2.519	27.702	1.00	20.00	C	O
  ATOM	8344	NE2	GLN	I	202	14.452	3.135	26.932	1.00	20.00	C	N
  ATOM	8345	C	GLN	I	202	13.142	0.816	32.489	1.00	42.35	C	C
  ATOM	8346	O	GLN	I	202	13.166	1.853	33.151	1.00	47.00	C	O
  ATOM	8347	N	LEU	I	203	12.318	−0.189	32.766	1.00	49.55	C	N
  ATOM	8348	CA	LEU	I	203	11.397	−0.111	33.895	1.00	50.77	C	C
  ATOM	8349	CB	LEU	I	203	10.332	−1.205	33.796	1.00	20.00	C	C
  ATOM	8350	CG	LEU	I	203	9.392	−1.066	32.594	1.00	20.00	C	C
  ATOM	8351	CD1	LEU	I	203	8.616	−2.347	32.316	1.00	20.00	C	C
  ATOM	8352	CD2	LEU	I	203	8.447	0.111	32.787	1.00	20.00	C	C
  ATOM	8353	C	LEU	I	203	12.134	−0.184	35.231	1.00	52.51	C	C
  ATOM	8354	O	LEU	I	203	13.096	−0.937	35.379	1.00	46.02	C	O
  ATOM	8355	N	LEU	I	204	11.747	0.686	36.159	1.00	51.45	C	N
  ATOM	8356	CA	LEU	I	204	12.308	0.682	37.507	1.00	58.44	C	C
  ATOM	8357	CB	LEU	I	204	12.055	2.021	38.187	1.00	20.00	C	C
  ATOM	8358	CG	LEU	I	204	12.780	3.206	37.565	1.00	20.00	C	C
  ATOM	8359	CD1	LEU	I	204	12.380	4.480	38.291	1.00	20.00	C	C
  ATOM	8360	CD2	LEU	I	204	14.286	2.982	37.637	1.00	20.00	C	C
  ATOM	8361	C	LEU	I	204	11.700	−0.425	38.354	1.00	54.99	C	C
  ATOM	8362	O	LEU	I	204	10.489	−0.633	38.319	1.00	55.13	C	O
  ATOM	8363	N	PRO	I	205	12.498	−0.979	39.277	1.00	58.64	C	N
  ATOM	8364	CA	PRO	I	205	12.014	−2.145	39.995	1.00	52.19	C	C
  ATOM	8365	CB	PRO	I	205	13.198	−2.496	40.896	1.00	20.00	C	C
  ATOM	8366	CG	PRO	I	205	13.924	−1.175	41.116	1.00	20.00	C	C
  ATOM	8367	CD	PRO	I	205	13.404	−0.175	40.112	1.00	20.00	C	C
  ATOM	8368	C	PRO	I	205	10.799	−1.765	40.840	1.00	54.30	C	C
  ATOM	8369	O	PRO	I	205	10.014	−2.630	41.235	1.00	70.22	C	O
  ATOM	8370	N	ILE	I	206	10.656	−0.465	41.096	1.00	62.70	C	N
  ATOM	8371	CA	ILE	I	206	9.491	0.087	41.787	1.00	68.19	C	C
  ATOM	8372	CB	ILE	I	206	9.725	0.181	43.311	1.00	20.00	C	C
  ATOM	8373	CG1	ILE	I	206	9.753	−1.214	43.941	1.00	20.00	C	C
  ATOM	8374	CD1	ILE	I	206	10.200	−1.220	45.389	1.00	20.00	C	C
  ATOM	8375	CG2	ILE	I	206	8.656	1.047	43.966	1.00	20.00	C	C
  ATOM	8376	C	ILE	I	206	9.175	1.484	41.253	1.00	62.35	C	C
  ATOM	8377	O	ILE	I	206	10.081	2.268	40.973	1.00	67.16	C	O
  ATOM	8378	N	VAL	I	207	7.894	1.749	41.015	1.00	52.22	C	N
  ATOM	8379	CA	VAL	I	207	7.461	3.050	40.521	1.00	51.31	C	C
  ATOM	8380	CB	VAL	I	207	6.469	2.918	39.345	1.00	20.00	C	C
  ATOM	8381	CG1	VAL	I	207	5.891	4.279	38.984	1.00	20.00	C	C
  ATOM	8382	CG2	VAL	I	207	7.149	2.291	38.139	1.00	20.00	C	C
  ATOM	8383	C	VAL	I	207	6.800	3.846	41.634	1.00	62.09	C	C
  ATOM	8384	O	VAL	I	207	5.644	3.607	41.980	1.00	58.88	C	O
  ATOM	8385	N	ASN	I	208	7.557	4.759	42.229	1.00	71.72	C	N
  ATOM	8386	CA	ASN	I	208	7.023	5.625	43.267	1.00	70.92	C	C
  ATOM	8387	CB	ASN	I	208	8.004	5.721	44.433	1.00	20.00	C	C
  ATOM	8388	CG	ASN	I	208	8.100	4.428	45.222	1.00	20.00	C	C
  ATOM	8389	OD1	ASN	I	208	7.170	3.620	45.228	1.00	20.00	C	O
  ATOM	8390	ND2	ASN	I	208	9.234	4.221	45.884	1.00	20.00	C	N
  ATOM	8391	C	ASN	I	208	6.699	7.015	42.735	1.00	63.05	C	C
  ATOM	8392	O	ASN	I	208	6.780	7.264	41.532	1.00	61.34	C	O
  ATOM	8393	N	LYS	I	209	6.391	7.933	43.645	1.00	68.91	C	N
  ATOM	8394	CA	LYS	I	209	5.953	9.273	43.274	1.00	59.11	C	C
  ATOM	8395	CB	LYS	I	209	5.349	9.992	44.482	1.00	20.00	C	C
  ATOM	8396	CG	LYS	I	209	4.044	9.391	44.979	1.00	20.00	C	C
  ATOM	8397	CD	LYS	I	209	3.507	10.158	46.179	1.00	20.00	C	C
  ATOM	8398	CE	LYS	I	209	2.159	9.612	46.629	1.00	20.00	C	C
  ATOM	8399	NZ	LYS	I	209	1.583	10.385	47.765	1.00	20.00	C	N
  ATOM	8400	C	LYS	I	209	7.100	10.100	42.702	1.00	50.69	C	C
  ATOM	8401	O	LYS	I	209	6.883	11.178	42.152	1.00	51.01	C	O
  ATOM	8402	N	GLN	I	210	8.326	9.638	42.920	1.00	44.68	C	N
  ATOM	8403	CA	GLN	I	210	9.495	10.293	42.349	1.00	49.52	C	C
  ATOM	8404	CB	GLN	I	210	10.724	10.052	43.223	1.00	20.00	C	C
  ATOM	8405	CG	GLN	I	210	10.667	10.739	44.573	1.00	20.00	C	C
  ATOM	8406	CD	GLN	I	210	11.865	10.409	45.435	1.00	20.00	C	C
  ATOM	8407	OE1	GLN	I	210	12.517	9.385	45.239	1.00	20.00	C	O
  ATOM	8408	NE2	GLN	I	210	12.173	11.286	46.383	1.00	20.00	C	N
  ATOM	8409	C	GLN	I	210	9.755	9.786	40.938	1.00	62.08	C	C
  ATOM	8410	O	GLN	I	210	9.786	10.560	39.983	1.00	80.43	C	O
  ATOM	8411	N	SER	I	211	9.902	8.472	40.813	1.00	58.92	C	N
  ATOM	8412	CA	SER	I	211	10.076	7.840	39.514	1.00	47.88	C	C
  ATOM	8413	CB	SER	I	211	9.987	6.319	39.647	1.00	20.00	C	C
  ATOM	8414	OG	SER	I	211	8.735	5.930	40.184	1.00	20.00	C	O
  ATOM	8415	C	SER	I	211	9.050	8.344	38.503	1.00	57.32	C	C
  ATOM	8416	O	SER	I	211	9.372	8.538	37.331	1.00	50.74	C	O
  ATOM	8417	N	CYS	I	212	7.845	8.647	38.979	1.00	44.34	C	N
  ATOM	8418	CA	CYS	I	212	6.690	8.758	38.095	1.00	57.52	C	C
  ATOM	8419	CB	CYS	I	212	5.453	9.307	38.834	1.00	20.00	C	C
  ATOM	8420	SG	CYS	I	212	4.771	8.198	40.141	1.00	20.00	C	S
  ATOM	8421	C	CYS	I	212	7.005	9.537	36.808	1.00	60.91	C	C
  ATOM	8422	O	CYS	I	212	6.991	8.952	35.727	1.00	52.17	C	O
  ATOM	8423	N	SER	I	213	7.305	10.827	36.916	1.00	21.55	C	N
  ATOM	8424	CA	SER	I	213	7.501	11.624	35.711	1.00	21.67	C	C
  ATOM	8425	CB	SER	I	213	7.747	13.090	36.075	1.00	21.81	C	C
  ATOM	8426	OG	SER	I	213	6.648	13.630	36.788	1.00	23.00	C	O
  ATOM	8427	C	SER	I	213	8.650	11.098	34.858	1.00	21.45	C	C
  ATOM	8428	O	SER	I	213	8.509	10.969	33.640	1.00	21.98	C	O
  ATOM	8429	N	ILE	I	214	9.775	10.772	35.484	1.00	20.90	C	N
  ATOM	8430	CA	ILE	I	214	10.875	10.168	34.746	1.00	20.45	C	C
  ATOM	8431	CB	ILE	I	214	12.127	10.002	35.624	1.00	20.53	C	C
  ATOM	8432	CG1	ILE	I	214	12.599	11.363	36.141	1.00	20.46	C	C
  ATOM	8433	CD1	ILE	I	214	13.831	11.289	37.016	1.00	21.75	C	C
  ATOM	8434	CG2	ILE	I	214	13.235	9.309	34.846	1.00	20.34	C	C
  ATOM	8435	C	ILE	I	214	10.423	8.802	34.247	1.00	20.15	C	C
  ATOM	8436	O	ILE	I	214	10.647	8.427	33.090	1.00	19.91	C	O
  ATOM	8437	N	SER	I	215	9.751	8.075	35.136	1.00	19.84	C	N
  ATOM	8438	CA	SER	I	215	9.240	6.749	34.827	1.00	19.58	C	C
  ATOM	8439	CB	SER	I	215	8.632	6.104	36.073	1.00	19.76	C	C
  ATOM	8440	OG	SER	I	215	8.132	4.810	35.785	1.00	19.97	C	O
  ATOM	8441	C	SER	I	215	8.201	6.841	33.724	1.00	19.34	C	C
  ATOM	8442	O	SER	I	215	8.172	6.013	32.818	1.00	19.54	C	O
  ATOM	8443	N	ASN	I	216	7.351	7.858	33.804	1.00	18.80	C	N
  ATOM	8444	CA	ASN	I	216	6.324	8.059	32.796	1.00	18.36	C	C
  ATOM	8445	CB	ASN	I	216	5.406	9.218	33.187	1.00	18.41	C	C
  ATOM	8446	CG	ASN	I	216	4.701	8.983	34.508	1.00	19.55	C	C
  ATOM	8447	OD1	ASN	I	216	3.922	9.819	34.967	1.00	20.52	C	O
  ATOM	8448	ND2	ASN	I	216	4.971	7.840	35.128	1.00	20.43	C	N
  ATOM	8449	C	ASN	I	216	6.958	8.324	31.440	1.00	17.78	C	C
  ATOM	8450	O	ASN	I	216	6.509	7.800	30.421	1.00	17.91	C	O
  ATOM	8451	N	ILE	I	217	8.016	9.130	31.433	1.00	17.02	C	N
  ATOM	8452	CA	ILE	I	217	8.714	9.439	30.194	1.00	16.60	C	C
  ATOM	8453	CB	ILE	I	217	9.833	10.472	30.417	1.00	16.46	C	C
  ATOM	8454	CG1	ILE	I	217	9.252	11.776	30.969	1.00	16.26	C	C
  ATOM	8455	CD1	ILE	I	217	10.289	12.849	31.217	1.00	16.44	C	C
  ATOM	8456	CG2	ILE	I	217	10.589	10.727	29.122	1.00	16.70	C	C
  ATOM	8457	C	ILE	I	217	9.314	8.168	29.609	1.00	16.73	C	C
  ATOM	8458	O	ILE	I	217	9.247	7.931	28.398	1.00	16.80	C	O
  ATOM	8459	N	GLU	I	218	9.885	7.339	30.478	1.00	17.02	C	N
  ATOM	8460	CA	GLU	I	218	10.485	6.090	30.031	1.00	17.70	C	C
  ATOM	8461	CB	GLU	I	218	11.172	5.376	31.197	1.00	18.20	C	C
  ATOM	8462	CG	GLU	I	218	12.289	6.178	31.844	1.00	21.31	C	C
  ATOM	8463	CD	GLU	I	218	12.951	5.437	32.989	1.00	25.72	C	C
  ATOM	8464	OE1	GLU	I	218	13.884	5.998	33.602	1.00	26.96	C	O
  ATOM	8465	OE2	GLU	I	218	12.538	4.294	33.277	1.00	27.07	C	O
  ATOM	8466	C	GLU	I	218	9.419	5.192	29.418	1.00	17.29	C	C
  ATOM	8467	O	GLU	I	218	9.642	4.555	28.387	1.00	17.62	C	O
  ATOM	8468	N	THR	I	219	8.253	5.156	30.055	1.00	16.62	C	N
  ATOM	8469	CA	THR	I	219	7.146	4.342	29.577	1.00	15.95	C	C
  ATOM	8470	CB	THR	I	219	5.952	4.387	30.547	1.00	15.95	C	C
  ATOM	8471	OG1	THR	I	219	6.356	3.894	31.831	1.00	15.63	C	O
  ATOM	8472	CG2	THR	I	219	4.806	3.536	30.021	1.00	15.97	C	C
  ATOM	8473	C	THR	I	219	6.696	4.825	28.207	1.00	15.64	C	C
  ATOM	8474	O	THR	I	219	6.414	4.022	27.321	1.00	15.93	C	O
  ATOM	8475	N	VAL	I	220	6.639	6.141	28.037	1.00	14.98	C	N
  ATOM	8476	CA	VAL	I	220	6.235	6.720	26.764	1.00	14.51	C	C
  ATOM	8477	CB	VAL	I	220	6.143	8.254	26.844	1.00	14.29	C	C
  ATOM	8478	CG1	VAL	I	220	5.716	8.830	25.502	1.00	14.24	C	C
  ATOM	8479	CG2	VAL	I	220	5.176	8.671	27.942	1.00	14.10	C	C
  ATOM	8480	C	VAL	I	220	7.233	6.334	25.682	1.00	14.64	C	C
  ATOM	8481	O	VAL	I	220	6.850	5.992	24.560	1.00	14.79	C	O
  ATOM	8482	N	ILE	I	221	8.516	6.375	26.028	1.00	14.43	C	N
  ATOM	8483	CA	ILE	I	221	9.556	6.013	25.075	1.00	14.36	C	C
  ATOM	8484	CB	ILE	I	221	10.962	6.235	25.661	1.00	14.03	C	C
  ATOM	8485	CG1	ILE	I	221	11.156	7.704	26.041	1.00	13.72	C	C
  ATOM	8486	CD1	ILE	I	221	11.011	8.660	24.877	1.00	14.17	C	C
  ATOM	8487	CG2	ILE	I	221	12.027	5.791	24.671	1.00	13.91	C	C
  ATOM	8488	C	ILE	I	221	9.404	4.552	24.672	1.00	14.82	C	C
  ATOM	8489	O	ILE	I	221	9.531	4.204	23.496	1.00	14.82	C	O
  ATOM	8490	N	GLU	I	222	9.112	3.703	25.652	1.00	15.51	C	N
  ATOM	8491	CA	GLU	I	222	8.936	2.281	25.392	1.00	16.52	C	C
  ATOM	8492	CB	GLU	I	222	8.730	1.517	26.701	1.00	16.80	C	C
  ATOM	8493	CG	GLU	I	222	9.889	1.635	27.677	1.00	19.14	C	C
  ATOM	8494	CD	GLU	I	222	9.653	0.861	28.959	1.00	22.62	C	C
  ATOM	8495	OE1	GLU	I	222	10.539	0.882	29.840	1.00	24.35	C	O
  ATOM	8496	OE2	GLU	I	222	8.583	0.230	29.086	1.00	23.98	C	O
  ATOM	8497	C	GLU	I	222	7.750	2.064	24.464	1.00	16.65	C	C
  ATOM	8498	O	GLU	I	222	7.802	1.238	23.553	1.00	16.95	C	O
  ATOM	8499	N	PHE	I	223	6.681	2.817	24.701	1.00	16.70	C	N
  ATOM	8500	CA	PHE	I	223	5.482	2.717	23.885	1.00	16.95	C	C
  ATOM	8501	CB	PHE	I	223	4.370	3.600	24.453	1.00	16.85	C	C
  ATOM	8502	CG	PHE	I	223	3.058	3.460	23.736	1.00	17.23	C	C
  ATOM	8503	CD1	PHE	I	223	2.127	2.519	24.145	1.00	17.98	C	C
  ATOM	8504	CE1	PHE	I	223	0.919	2.387	23.488	1.00	18.28	C	C
  ATOM	8505	CZ	PHE	I	223	0.629	3.199	22.409	1.00	18.19	C	C
  ATOM	8506	CE2	PHE	I	223	1.548	4.140	21.991	1.00	18.14	C	C
  ATOM	8507	CD2	PHE	I	223	2.755	4.267	22.653	1.00	17.75	C	C
  ATOM	8508	C	PHE	I	223	5.790	3.119	22.450	1.00	17.28	C	C
  ATOM	8509	O	PHE	I	223	5.324	2.482	21.506	1.00	17.17	C	O
  ATOM	8510	N	GLN	I	224	6.581	4.175	22.287	1.00	17.62	C	N
  ATOM	8511	CA	GLN	I	224	6.954	4.619	20.952	1.00	18.16	C	C
  ATOM	8512	CB	GLN	I	224	7.759	5.918	21.021	1.00	18.51	C	C
  ATOM	8513	CG	GLN	I	224	7.015	7.075	21.669	1.00	20.06	C	C
  ATOM	8514	CD	GLN	I	224	7.842	8.344	21.718	1.00	22.03	C	C
  ATOM	8515	OE1	GLN	I	224	7.387	9.376	22.214	1.00	22.15	C	O
  ATOM	8516	NE2	GLN	I	224	9.064	8.275	21.203	1.00	22.11	C	N
  ATOM	8517	C	GLN	I	224	7.767	3.532	20.261	1.00	18.04	C	C
  ATOM	8518	O	GLN	I	224	7.561	3.238	19.083	1.00	18.17	C	O
  ATOM	8519	N	GLN	I	225	8.688	2.933	21.009	1.00	17.90	C	N
  ATOM	8520	CA	GLN	I	225	9.508	1.840	20.500	1.00	17.95	C	C
  ATOM	8521	CB	GLN	I	225	10.599	1.474	21.509	1.00	18.13	C	C
  ATOM	8522	CG	GLN	I	225	11.551	2.613	21.833	1.00	19.04	C	C
  ATOM	8523	CD	GLN	I	225	12.619	2.213	22.831	1.00	21.22	C	C
  ATOM	8524	OE1	GLN	I	225	12.659	1.072	23.292	1.00	22.55	C	O
  ATOM	8525	NE2	GLN	I	225	13.493	3.154	23.172	1.00	22.48	C	N
  ATOM	8526	C	GLN	I	225	8.664	0.611	20.172	1.00	17.84	C	C
  ATOM	8527	O	GLN	I	225	8.892	−0.068	19.171	1.00	17.71	C	O
  ATOM	8528	N	LYS	I	226	7.693	0.334	21.036	1.00	17.95	C	N
  ATOM	8529	CA	LYS	I	226	6.848	−0.831	20.912	1.00	18.00	C	C
  ATOM	8530	CB	LYS	I	226	6.821	−1.593	22.234	1.00	18.21	C	C
  ATOM	8531	CG	LYS	I	226	8.189	−1.697	22.905	1.00	18.50	C	C
  ATOM	8532	CD	LYS	I	226	8.132	−2.591	24.132	1.00	19.87	C	C
  ATOM	8533	CE	LYS	I	226	9.357	−2.411	25.004	1.00	21.36	C	C
  ATOM	8534	NZ	LYS	I	226	9.268	−3.230	26.248	1.00	21.83	C	N
  ATOM	8535	C	LYS	I	226	5.446	−0.408	20.499	1.00	17.84	C	C
  ATOM	8536	O	LYS	I	226	4.672	−1.220	19.998	1.00	17.94	C	O
  ATOM	8537	N	ASN	I	227	5.209	0.900	20.514	1.00	17.70	C	N
  ATOM	8538	CA	ASN	I	227	4.173	1.494	19.683	1.00	17.66	C	C
  ATOM	8539	CB	ASN	I	227	3.153	2.256	20.549	1.00	17.36	C	C
  ATOM	8540	CG	ASN	I	227	2.612	1.411	21.710	1.00	17.40	C	C
  ATOM	8541	OD1	ASN	I	227	2.451	0.196	21.589	1.00	17.84	C	O
  ATOM	8542	ND2	ASN	I	227	2.333	2.059	22.834	1.00	17.22	C	N
  ATOM	8543	C	ASN	I	227	4.713	2.343	18.506	1.00	17.76	C	C
  ATOM	8544	O	ASN	I	227	3.943	2.750	17.635	1.00	17.92	C	O
  ATOM	8545	N	ASN	I	228	6.045	2.460	18.398	1.00	17.78	C	N
  ATOM	8546	CA	ASN	I	228	6.734	2.532	17.084	1.00	17.59	C	C
  ATOM	8547	CB	ASN	I	228	8.170	3.085	17.155	1.00	17.89	C	C
  ATOM	8548	CG	ASN	I	228	8.870	3.082	15.779	1.00	18.43	C	C
  ATOM	8549	OD1	ASN	I	228	9.451	2.077	15.366	1.00	18.74	C	O
  ATOM	8550	ND2	ASN	I	228	8.682	4.157	15.022	1.00	18.61	C	N
  ATOM	8551	C	ASN	I	228	6.765	1.204	16.358	1.00	17.09	C	C
  ATOM	8552	O	ASN	I	228	6.004	0.992	15.417	1.00	17.17	C	O
  ATOM	8553	N	ARG	I	229	7.685	0.328	16.745	1.00	16.33	C	N
  ATOM	8554	CA	ARG	I	229	7.664	−1.016	16.195	1.00	15.76	C	C
  ATOM	8555	CB	ARG	I	229	8.624	−1.952	16.933	1.00	15.70	C	C
  ATOM	8556	CG	ARG	I	229	9.369	−2.904	16.000	1.00	14.99	C	C
  ATOM	8557	CD	ARG	I	229	9.887	−4.135	16.728	1.00	15.33	C	C
  ATOM	8558	NE	ARG	I	229	9.601	−5.376	16.008	1.00	15.59	C	N
  ATOM	8559	CZ	ARG	I	229	9.926	−6.587	16.451	1.00	15.85	C	C
  ATOM	8560	NH1	ARG	I	229	10.559	−6.725	17.609	1.00	16.20	C	N
  ATOM	8561	NH2	ARG	I	229	9.650	−7.660	15.722	1.00	16.63	C	N
  ATOM	8562	C	ARG	I	229	6.238	−1.559	16.223	1.00	15.62	C	C
  ATOM	8563	O	ARG	I	229	5.666	−1.860	15.175	1.00	15.73	C	O
  ATOM	8564	N	LEU	I	230	5.601	−1.468	17.387	1.00	15.46	C	N
  ATOM	8565	CA	LEU	I	230	4.191	−1.829	17.511	1.00	15.22	C	C
  ATOM	8566	CB	LEU	I	230	3.735	−1.792	18.974	1.00	15.08	C	C
  ATOM	8567	CG	LEU	I	230	2.252	−2.079	19.224	1.00	14.70	C	C
  ATOM	8568	CD1	LEU	I	230	2.003	−3.572	19.359	1.00	15.19	C	C
  ATOM	8569	CD2	LEU	I	230	1.743	−1.335	20.449	1.00	15.46	C	C
  ATOM	8570	C	LEU	I	230	3.302	−0.931	16.655	1.00	15.31	C	C
  ATOM	8571	O	LEU	I	230	2.417	−1.415	15.950	1.00	15.46	C	O
  ATOM	8572	N	LEU	I	231	3.519	0.377	16.745	1.00	15.48	C	N
  ATOM	8573	CA	LEU	I	231	2.678	1.338	16.038	1.00	15.75	C	C
  ATOM	8574	CB	LEU	I	231	3.187	2.763	16.257	1.00	15.90	C	C
  ATOM	8575	CG	LEU	I	231	2.906	3.379	17.628	1.00	16.63	C	C
  ATOM	8576	CD1	LEU	I	231	3.382	4.819	17.676	1.00	18.45	C	C
  ATOM	8577	CD2	LEU	I	231	1.425	3.292	17.961	1.00	16.67	C	C
  ATOM	8578	C	LEU	I	231	2.653	1.025	14.551	1.00	15.76	C	C
  ATOM	8579	O	LEU	I	231	1.606	1.092	13.908	1.00	15.84	C	O
  ATOM	8580	N	GLU	I	232	3.828	0.750	13.997	1.00	15.71	C	N
  ATOM	8581	CA	GLU	I	232	3.973	0.563	12.562	1.00	15.93	C	C
  ATOM	8582	CB	GLU	I	232	5.447	0.626	12.163	1.00	16.15	C	C
  ATOM	8583	CG	GLU	I	232	6.142	1.913	12.568	1.00	18.59	C	C
  ATOM	8584	CD	GLU	I	232	6.407	2.823	11.387	1.00	21.47	C	C
  ATOM	8585	OE1	GLU	I	232	5.892	2.532	10.286	1.00	22.14	C	O
  ATOM	8586	OE2	GLU	I	232	7.214	3.765	11.530	1.00	23.34	C	O
  ATOM	8587	C	GLU	I	232	3.377	−0.767	12.124	1.00	15.45	C	C
  ATOM	8588	O	GLU	I	232	2.921	−0.908	10.990	1.00	15.95	C	O
  ATOM	8589	N	ILE	I	233	3.432	−1.757	13.007	1.00	14.54	C	N
  ATOM	8590	CA	ILE	I	233	2.713	−3.000	12.776	1.00	13.69	C	C
  ATOM	8591	CB	ILE	I	233	2.998	−4.028	13.873	1.00	13.63	C	C
  ATOM	8592	CG1	ILE	I	233	4.500	−4.093	14.151	1.00	13.58	C	C
  ATOM	8593	CD1	ILE	I	233	4.854	−4.786	15.444	1.00	13.55	C	C
  ATOM	8594	CG2	ILE	I	233	2.458	−5.392	13.469	1.00	13.88	C	C
  ATOM	8595	C	ILE	I	233	1.219	−2.728	12.735	1.00	13.28	C	C
  ATOM	8596	O	ILE	I	233	0.528	−3.137	11.802	1.00	13.04	C	O
  ATOM	8597	N	THR	I	234	0.764	−1.898	13.667	1.00	13.18	C	N
  ATOM	8598	CA	THR	I	234	−0.651	−1.590	13.796	1.00	13.39	C	C
  ATOM	8599	CB	THR	I	234	−0.913	−0.636	14.974	1.00	13.21	C	C
  ATOM	8600	OG1	THR	I	234	−0.476	−1.248	16.193	1.00	13.15	C	O
  ATOM	8601	CG2	THR	I	234	−2.395	−0.311	15.078	1.00	13.22	C	C
  ATOM	8602	C	THR	I	234	−1.208	−0.981	12.514	1.00	13.76	C	C
  ATOM	8603	O	THR	I	234	−2.230	−1.432	11.997	1.00	13.95	C	O
  ATOM	8604	N	ARG	I	235	−0.535	0.045	12.003	1.00	14.26	C	N
  ATOM	8605	CA	ARG	I	235	−0.945	0.670	10.752	1.00	14.92	C	C
  ATOM	8606	CB	ARG	I	235	−0.051	1.874	10.432	1.00	15.30	C	C
  ATOM	8607	CG	ARG	I	235	0.875	1.681	9.240	1.00	16.27	C	C
  ATOM	8608	CD	ARG	I	235	2.190	2.436	9.413	1.00	18.52	C	C
  ATOM	8609	NE	ARG	I	235	2.083	3.558	10.344	1.00	17.86	C	N
  ATOM	8610	CZ	ARG	I	235	1.516	4.724	10.051	1.00	16.91	C	C
  ATOM	8611	NH1	ARG	I	235	0.855	4.874	8.912	1.00	16.59	C	N
  ATOM	8612	NH2	ARG	I	235	1.511	5.703	10.946	1.00	16.86	C	N
  ATOM	8613	C	ARG	I	235	−0.904	−0.353	9.620	1.00	15.05	C	C
  ATOM	8614	O	ARG	I	235	−1.939	−0.693	9.045	1.00	15.15	C	O
  ATOM	8615	N	GLU	I	236	0.240	−1.020	9.504	1.00	15.18	C	N
  ATOM	8616	CA	GLU	I	236	0.451	−2.047	8.490	1.00	15.24	C	C
  ATOM	8617	CB	GLU	I	236	1.725	−2.835	8.801	1.00	15.69	C	C
  ATOM	8618	CG	GLU	I	236	2.432	−3.396	7.580	1.00	18.22	C	C
  ATOM	8619	CD	GLU	I	236	3.760	−4.040	7.926	1.00	21.59	C	C
  ATOM	8620	OE1	GLU	I	236	4.381	−4.645	7.027	1.00	24.41	C	O
  ATOM	8621	OE2	GLU	I	236	4.182	−3.944	9.097	1.00	21.59	C	O
  ATOM	8622	C	GLU	I	236	−0.735	−2.999	8.400	1.00	14.61	C	C
  ATOM	8623	O	GLU	I	236	−1.191	−3.334	7.307	1.00	14.82	C	O
  ATOM	8624	N	PHE	I	237	−1.184	−3.485	9.552	1.00	14.05	C	N
  ATOM	8625	CA	PHE	I	237	−2.318	−4.397	9.602	1.00	13.84	C	C
  ATOM	8626	CB	PHE	I	237	−2.466	−4.996	11.003	1.00	14.04	C	C
  ATOM	8627	CG	PHE	I	237	−1.643	−6.235	11.225	1.00	14.84	C	C
  ATOM	8628	CD1	PHE	I	237	−0.734	−6.296	12.267	1.00	15.30	C	C
  ATOM	8629	CE1	PHE	I	237	−0.006	−7.446	12.503	1.00	15.15	C	C
  ATOM	8630	CZ	PHE	I	237	−0.197	−8.557	11.708	1.00	15.19	C	C
  ATOM	8631	CE2	PHE	I	237	−1.110	−8.514	10.673	1.00	15.02	C	C
  ATOM	8632	CD2	PHE	I	237	−1.831	−7.360	10.439	1.00	15.03	C	C
  ATOM	8633	C	PHE	I	237	−3.607	−3.689	9.195	1.00	13.51	C	C
  ATOM	8634	O	PHE	I	237	−4.387	−4.213	8.399	1.00	13.43	C	O
  ATOM	8635	N	SER	I	238	−3.830	−2.503	9.754	1.00	13.11	C	N
  ATOM	8636	CA	SER	I	238	−5.032	−1.729	9.460	1.00	12.82	C	C
  ATOM	8637	CB	SER	I	238	−5.049	−0.438	10.279	1.00	12.86	C	C
  ATOM	8638	OG	SER	I	238	−5.205	−0.711	11.660	1.00	12.76	C	O
  ATOM	8639	C	SER	I	238	−5.104	−1.400	7.977	1.00	12.69	C	C
  ATOM	8640	O	SER	I	238	−6.187	−1.237	7.414	1.00	12.63	C	O
  ATOM	8641	N	VAL	I	239	−3.937	−1.313	7.349	1.00	12.59	C	N
  ATOM	8642	CA	VAL	I	239	−3.858	−1.042	5.923	1.00	12.80	C	C
  ATOM	8643	CB	VAL	I	239	−2.482	−0.473	5.524	1.00	12.71	C	C
  ATOM	8644	CG1	VAL	I	239	−2.390	−0.321	4.012	1.00	13.63	C	C
  ATOM	8645	CG2	VAL	I	239	−2.239	0.859	6.214	1.00	13.57	C	C
  ATOM	8646	C	VAL	I	239	−4.144	−2.286	5.090	1.00	12.94	C	C
  ATOM	8647	O	VAL	I	239	−4.320	−2.190	3.877	1.00	13.10	C	O
  ATOM	8648	N	ASN	I	240	−4.139	−3.458	5.721	1.00	4.15	C	N
  ATOM	8649	CA	ASN	I	240	−4.166	−4.709	4.966	1.00	4.33	C	C
  ATOM	8650	CB	ASN	I	240	−2.941	−5.569	5.281	1.00	4.59	C	C
  ATOM	8651	CG	ASN	I	240	−1.674	−5.027	4.647	1.00	5.36	C	C
  ATOM	8652	OD1	ASN	I	240	−1.524	−5.043	3.423	1.00	6.27	C	O
  ATOM	8653	ND2	ASN	I	240	−0.816	−4.427	5.465	1.00	7.15	C	N
  ATOM	8654	C	ASN	I	240	−5.454	−5.529	5.074	1.00	4.19	C	C
  ATOM	8655	O	ASN	I	240	−5.634	−6.507	4.347	1.00	4.19	C	O
  ATOM	8656	N	ALA	I	241	−6.385	−5.073	5.904	1.00	3.93	C	N
  ATOM	8657	CA	ALA	I	241	−7.593	−5.840	6.186	1.00	3.90	C	C
  ATOM	8658	CB	ALA	I	241	−8.563	−5.749	5.020	1.00	3.86	C	C
  ATOM	8659	C	ALA	I	241	−7.253	−7.297	6.491	1.00	4.22	C	C
  ATOM	8660	O	ALA	I	241	−7.778	−8.212	5.856	1.00	4.47	C	O
  ATOM	8661	N	GLY	I	242	−6.289	−7.497	7.386	1.00	4.53	C	N
  ATOM	8662	CA	GLY	I	242	−6.124	−8.774	8.078	1.00	4.65	C	C
  ATOM	8663	C	GLY	I	242	−5.398	−9.848	7.282	1.00	4.67	C	C
  ATOM	8664	O	GLY	I	242	−5.496	−11.034	7.600	1.00	5.27	C	O
  ATOM	8665	N	VAL	I	243	−4.611	−9.433	6.292	1.00	4.37	C	N
  ATOM	8666	CA	VAL	I	243	−3.780	−10.366	5.531	1.00	4.32	C	C
  ATOM	8667	CB	VAL	I	243	−4.570	−11.042	4.389	1.00	3.99	C	C
  ATOM	8668	CG1	VAL	I	243	−3.987	−12.411	4.078	1.00	4.22	C	C
  ATOM	8669	CG2	VAL	I	243	−6.042	−11.154	4.748	1.00	3.85	C	C
  ATOM	8670	C	VAL	I	243	−2.571	−9.658	4.932	1.00	4.61	C	C
  ATOM	8671	O	VAL	I	243	−2.704	−8.607	4.308	1.00	4.89	C	O
  ATOM	8672	N	THR	I	244	−1.402	−10.269	5.072	1.00	4.95	C	N
  ATOM	8673	CA	THR	I	244	−0.168	−9.654	4.604	1.00	5.71	C	C
  ATOM	8674	CB	THR	I	244	0.678	−9.128	5.775	1.00	6.11	C	C
  ATOM	8675	OG1	THR	I	244	−0.078	−9.209	6.989	1.00	7.17	C	O
  ATOM	8676	CG2	THR	I	244	1.091	−7.686	5.532	1.00	7.55	C	C
  ATOM	8677	C	THR	I	244	0.664	−10.649	3.813	1.00	5.61	C	C
  ATOM	8678	O	THR	I	244	0.811	−11.803	4.214	1.00	5.85	C	O
  ATOM	8679	N	THR	I	245	1.346	−10.150	2.791	1.00	5.53	C	N
  ATOM	8680	CA	THR	I	245	2.556	−10.791	2.308	1.00	5.81	C	C
  ATOM	8681	CB	THR	I	245	2.426	−11.170	0.818	1.00	6.13	C	C
  ATOM	8682	OG1	THR	I	245	1.421	−12.181	0.668	1.00	8.11	C	O
  ATOM	8683	CG2	THR	I	245	3.746	−11.696	0.281	1.00	6.63	C	C
  ATOM	8684	C	THR	I	245	3.748	−9.865	2.542	1.00	5.73	C	C
  ATOM	8685	O	THR	I	245	3.568	−8.705	2.916	1.00	5.86	C	O
  ATOM	8686	N	PRO	I	246	4.963	−10.337	2.223	1.00	5.68	C	N
  ATOM	8687	CA	PRO	I	246	5.942	−10.579	3.269	1.00	5.11	C	C
  ATOM	8688	CB	PRO	I	246	6.802	−9.317	3.210	1.00	5.19	C	C
  ATOM	8689	CG	PRO	I	246	6.717	−8.878	1.734	1.00	5.90	C	C
  ATOM	8690	CD	PRO	I	246	5.613	−9.691	1.074	1.00	6.36	C	C
  ATOM	8691	C	PRO	I	246	5.360	−10.786	4.664	1.00	4.85	C	C
  ATOM	8692	O	PRO	I	246	4.465	−10.053	5.084	1.00	5.25	C	O
  ATOM	8693	N	VAL	I	247	5.795	−11.859	5.316	1.00	4.35	C	N
  ATOM	8694	CA	VAL	I	247	5.555	−12.048	6.739	1.00	3.82	C	C
  ATOM	8695	CB	VAL	I	247	5.603	−13.536	7.127	1.00	3.52	C	C
  ATOM	8696	CG1	VAL	I	247	5.206	−13.717	8.584	1.00	3.62	C	C
  ATOM	8697	CG2	VAL	I	247	4.694	−14.347	6.218	1.00	3.60	C	C
  ATOM	8698	C	VAL	I	247	6.576	−11.271	7.558	1.00	3.69	C	C
  ATOM	8699	O	VAL	I	247	7.744	−11.653	7.641	1.00	3.36	C	O
  ATOM	8700	N	SER	I	248	6.172	−10.077	7.973	1.00	3.72	C	N
  ATOM	8701	CA	SER	I	248	7.077	−9.138	8.611	1.00	3.96	C	C
  ATOM	8702	CB	SER	I	248	6.291	−7.973	9.214	1.00	4.07	C	C
  ATOM	8703	OG	SER	I	248	5.661	−8.356	10.425	1.00	4.13	C	O
  ATOM	8704	C	SER	I	248	7.885	−9.830	9.695	1.00	4.35	C	C
  ATOM	8705	O	SER	I	248	7.453	−10.838	10.257	1.00	4.36	C	O
  ATOM	8706	N	THR	I	249	9.008	−9.223	10.057	1.00	4.53	C	N
  ATOM	8707	CA	THR	I	249	9.752	−9.638	11.235	1.00	4.61	C	C
  ATOM	8708	CB	THR	I	249	11.104	−8.916	11.329	1.00	4.70	C	C
  ATOM	8709	OG1	THR	I	249	10.889	−7.544	11.679	1.00	5.42	C	O
  ATOM	8710	CG2	THR	I	249	11.833	−8.984	9.999	1.00	4.88	C	C
  ATOM	8711	C	THR	I	249	8.955	−9.383	12.509	1.00	4.47	C	C
  ATOM	8712	O	THR	I	249	9.321	−9.861	13.584	1.00	4.74	C	O
  ATOM	8713	N	TYR	I	250	7.864	−8.633	12.388	1.00	4.32	C	N
  ATOM	8714	CA	TYR	I	250	6.956	−8.435	13.512	1.00	4.42	C	C
  ATOM	8715	CB	TYR	I	250	6.195	−7.113	13.381	1.00	4.91	C	C
  ATOM	8716	CG	TYR	I	250	7.072	−5.881	13.272	1.00	6.81	C	C
  ATOM	8717	CD1	TYR	I	250	6.791	−4.897	12.333	1.00	8.89	C	C
  ATOM	8718	CE1	TYR	I	250	7.556	−3.752	12.243	1.00	10.73	C	C
  ATOM	8719	CZ	TYR	I	250	8.587	−3.549	13.137	1.00	12.28	C	C
  ATOM	8720	OH	TYR	I	250	9.370	−2.421	13.032	1.00	12.24	C	O
  ATOM	8721	CE2	TYR	I	250	8.851	−4.483	14.121	1.00	12.15	C	C
  ATOM	8722	CD2	TYR	I	250	8.067	−5.621	14.209	1.00	9.81	C	C
  ATOM	8723	C	TYR	I	250	5.973	−9.592	13.662	1.00	4.21	C	C
  ATOM	8724	O	TYR	I	250	5.525	−9.893	14.768	1.00	4.20	C	O
  ATOM	8725	N	MET	I	251	5.574	−10.183	12.541	1.00	4.14	C	N
  ATOM	8726	CA	MET	I	251	4.731	−11.372	12.574	1.00	4.15	C	C
  ATOM	8727	CB	MET	I	251	4.160	−11.662	11.187	1.00	4.14	C	C
  ATOM	8728	CG	MET	I	251	3.297	−10.547	10.630	1.00	4.51	C	C
  ATOM	8729	SD	MET	I	251	1.731	−10.386	11.505	1.00	3.81	C	S
  ATOM	8730	CE	MET	I	251	0.800	−9.412	10.327	1.00	4.55	C	C
  ATOM	8731	C	MET	I	251	5.540	−12.565	13.057	1.00	4.13	C	C
  ATOM	8732	O	MET	I	251	5.127	−13.289	13.964	1.00	4.24	C	O
  ATOM	8733	N	LEU	I	252	6.728	−12.718	12.487	1.00	4.23	C	N
  ATOM	8734	CA	LEU	I	252	7.586	−13.848	12.792	1.00	4.22	C	C
  ATOM	8735	CB	LEU	I	252	7.586	−14.839	11.631	1.00	4.14	C	C
  ATOM	8736	CG	LEU	I	252	6.703	−16.071	11.816	1.00	4.05	C	C
  ATOM	8737	CD1	LEU	I	252	7.171	−17.204	10.918	1.00	5.22	C	C
  ATOM	8738	CD2	LEU	I	252	6.692	−16.508	13.273	1.00	6.20	C	C
  ATOM	8739	C	LEU	I	252	8.998	−13.356	13.040	1.00	4.62	C	C
  ATOM	8740	O	LEU	I	252	9.599	−12.712	12.182	1.00	4.97	C	O
  ATOM	8741	N	THR	I	253	9.531	−13.670	14.212	1.00	4.90	C	N
  ATOM	8742	CA	THR	I	253	10.942	−13.463	14.472	1.00	5.57	C	C
  ATOM	8743	CB	THR	I	253	11.265	−13.708	15.946	1.00	5.55	C	C
  ATOM	8744	OG1	THR	I	253	10.337	−12.987	16.765	1.00	6.43	C	O
  ATOM	8745	CG2	THR	I	253	12.673	−13.251	16.259	1.00	6.28	C	C
  ATOM	8746	C	THR	I	253	11.753	−14.424	13.622	1.00	6.03	C	C
  ATOM	8747	O	THR	I	253	11.315	−15.541	13.349	1.00	6.68	C	O
  ATOM	8748	N	ASN	I	254	12.961	−14.015	13.255	1.00	6.39	C	N
  ATOM	8749	CA	ASN	I	254	13.951	−14.973	12.800	1.00	6.79	C	C
  ATOM	8750	CB	ASN	I	254	15.341	−14.348	12.762	1.00	6.85	C	C
  ATOM	8751	CG	ASN	I	254	16.324	−15.177	11.964	1.00	6.81	C	C
  ATOM	8752	OD1	ASN	I	254	16.152	−15.366	10.760	1.00	7.67	C	O
  ATOM	8753	ND2	ASN	I	254	17.271	−15.799	12.657	1.00	6.19	C	N
  ATOM	8754	C	ASN	I	254	13.964	−16.211	13.686	1.00	7.08	C	C
  ATOM	8755	O	ASN	I	254	13.654	−17.312	13.231	1.00	6.90	C	O
  ATOM	8756	N	SER	I	255	14.283	−16.017	14.962	1.00	7.21	C	N
  ATOM	8757	CA	SER	I	255	14.292	−17.112	15.929	1.00	7.37	C	C
  ATOM	8758	CB	SER	I	255	14.338	−16.568	17.360	1.00	8.09	C	C
  ATOM	8759	OG	SER	I	255	14.953	−15.293	17.407	1.00	10.47	C	O
  ATOM	8760	C	SER	I	255	13.078	−18.024	15.750	1.00	6.82	C	C
  ATOM	8761	O	SER	I	255	13.205	−19.249	15.768	1.00	6.99	C	O
  ATOM	8762	N	GLU	I	256	11.901	−17.422	15.611	1.00	6.17	C	N
  ATOM	8763	CA	GLU	I	256	10.658	−18.184	15.544	1.00	6.13	C	C
  ATOM	8764	CB	GLU	I	256	9.452	−17.266	15.742	1.00	6.22	C	C
  ATOM	8765	CG	GLU	I	256	9.210	−16.863	17.185	1.00	8.41	C	C
  ATOM	8766	CD	GLU	I	256	8.527	−15.516	17.299	1.00	10.26	C	C
  ATOM	8767	OE1	GLU	I	256	8.232	−14.907	16.248	1.00	11.90	C	O
  ATOM	8768	OE2	GLU	I	256	8.275	−15.070	18.437	1.00	9.55	C	O
  ATOM	8769	C	GLU	I	256	10.535	−18.895	14.209	1.00	5.76	C	C
  ATOM	8770	O	GLU	I	256	10.154	−20.064	14.154	1.00	5.93	C	O
  ATOM	8771	N	LEU	I	257	10.669	−18.124	13.134	1.00	5.67	C	N
  ATOM	8772	CA	LEU	I	257	10.638	−18.679	11.787	1.00	5.37	C	C
  ATOM	8773	CB	LEU	I	257	11.010	−17.613	10.753	1.00	5.03	C	C
  ATOM	8774	CG	LEU	I	257	11.316	−18.130	9.344	1.00	3.65	C	C
  ATOM	8775	CD1	LEU	I	257	10.067	−18.702	8.689	1.00	2.00	C	C
  ATOM	8776	CD2	LEU	I	257	11.917	−17.030	8.485	1.00	2.14	C	C
  ATOM	8777	C	LEU	I	257	11.580	−19.871	11.670	1.00	5.64	C	C
  ATOM	8778	O	LEU	I	257	11.234	−20.895	11.079	1.00	5.81	C	O
  ATOM	8779	N	LEU	I	258	12.764	−19.741	12.259	1.00	5.75	C	N
  ATOM	8780	CA	LEU	I	258	13.808	−20.739	12.081	1.00	5.91	C	C
  ATOM	8781	CB	LEU	I	258	15.156	−20.215	12.583	1.00	6.10	C	C
  ATOM	8782	CG	LEU	I	258	16.059	−19.626	11.495	1.00	5.75	C	C
  ATOM	8783	CD1	LEU	I	258	17.208	−18.836	12.101	1.00	6.33	C	C
  ATOM	8784	CD2	LEU	I	258	16.577	−20.724	10.577	1.00	7.33	C	C
  ATOM	8785	C	LEU	I	258	13.464	−22.074	12.736	1.00	6.03	C	C
  ATOM	8786	O	LEU	I	258	13.589	−23.125	12.109	1.00	5.73	C	O
  ATOM	8787	N	SER	I	259	12.980	−22.030	13.974	1.00	6.47	C	N
  ATOM	8788	CA	SER	I	259	12.538	−23.243	14.662	1.00	6.95	C	C
  ATOM	8789	CB	SER	I	259	12.400	−23.000	16.168	1.00	7.05	C	C
  ATOM	8790	OG	SER	I	259	11.147	−23.460	16.650	1.00	6.86	C	O
  ATOM	8791	C	SER	I	259	11.220	−23.759	14.097	1.00	6.74	C	C
  ATOM	8792	O	SER	I	259	10.905	−24.943	14.213	1.00	6.86	C	O
  ATOM	8793	N	LEU	I	260	10.411	−22.844	13.576	1.00	6.31	C	N
  ATOM	8794	CA	LEU	I	260	9.188	−23.211	12.880	1.00	6.09	C	C
  ATOM	8795	CB	LEU	I	260	8.407	−21.957	12.484	1.00	6.09	C	C
  ATOM	8796	CG	LEU	I	260	7.140	−21.665	13.291	1.00	6.24	C	C
  ATOM	8797	CD1	LEU	I	260	6.291	−20.595	12.611	1.00	6.53	C	C
  ATOM	8798	CD2	LEU	I	260	6.337	−22.944	13.521	1.00	5.98	C	C
  ATOM	8799	C	LEU	I	260	9.497	−24.047	11.644	1.00	6.25	C	C
  ATOM	8800	O	LEU	I	260	8.809	−25.028	11.361	1.00	6.37	C	O
  ATOM	8801	N	ILE	I	261	10.452	−23.580	10.847	1.00	6.63	C	N
  ATOM	8802	CA	ILE	I	261	10.952	−24.360	9.723	1.00	7.19	C	C
  ATOM	8803	CB	ILE	I	261	12.165	−23.681	9.061	1.00	7.09	C	C
  ATOM	8804	CG1	ILE	I	261	11.703	−22.635	8.046	1.00	7.46	C	C
  ATOM	8805	CD1	ILE	I	261	12.646	−21.460	7.909	1.00	8.38	C	C
  ATOM	8806	CG2	ILE	I	261	13.055	−24.718	8.391	1.00	6.61	C	C
  ATOM	8807	C	ILE	I	261	11.389	−25.723	10.228	1.00	8.01	C	C
  ATOM	8808	O	ILE	I	261	10.967	−26.758	9.713	1.00	8.26	C	O
  ATOM	8809	N	ASN	I	262	12.206	−25.708	11.273	1.00	9.05	C	N
  ATOM	8810	CA	ASN	I	262	12.640	−26.935	11.912	1.00	9.88	C	C
  ATOM	8811	CB	ASN	I	262	13.220	−26.636	13.292	1.00	9.99	C	C
  ATOM	8812	CG	ASN	I	262	14.327	−27.590	13.672	1.00	11.16	C	C
  ATOM	8813	OD1	ASN	I	262	14.709	−28.457	12.886	1.00	12.70	C	O
  ATOM	8814	ND2	ASN	I	262	14.912	−27.379	14.844	1.00	13.20	C	N
  ATOM	8815	C	ASN	I	262	11.500	−27.939	12.023	1.00	10.17	C	C
  ATOM	8816	O	ASN	I	262	11.661	−29.108	11.675	1.00	10.52	C	O
  ATOM	8817	N	ASP	I	263	10.315	−27.444	12.368	1.00	10.62	C	N
  ATOM	8818	CA	ASP	I	263	9.203	−28.311	12.741	1.00	11.02	C	C
  ATOM	8819	CB	ASP	I	263	8.230	−27.584	13.675	1.00	11.49	C	C
  ATOM	8820	CG	ASP	I	263	7.026	−28.435	14.040	1.00	12.80	C	C
  ATOM	8821	OD1	ASP	I	263	7.219	−29.586	14.487	1.00	14.72	C	O
  ATOM	8822	OD2	ASP	I	263	5.886	−27.978	13.811	1.00	13.88	C	O
  ATOM	8823	C	ASP	I	263	8.460	−28.855	11.520	1.00	10.92	C	C
  ATOM	8824	O	ASP	I	263	7.619	−29.748	11.642	1.00	10.96	C	O
  ATOM	8825	N	MET	I	264	8.807	−28.346	10.341	1.00	10.91	C	N
  ATOM	8826	CA	MET	I	264	8.105	−28.707	9.110	1.00	10.78	C	C
  ATOM	8827	CB	MET	I	264	8.397	−27.687	8.007	1.00	10.51	C	C
  ATOM	8828	CG	MET	I	264	7.934	−26.276	8.329	1.00	11.26	C	C
  ATOM	8829	SD	MET	I	264	8.142	−25.144	6.942	1.00	12.70	C	S
  ATOM	8830	CE	MET	I	264	9.799	−25.565	6.411	1.00	13.92	C	C
  ATOM	8831	C	MET	I	264	8.466	−30.116	8.631	1.00	10.85	C	C
  ATOM	8832	O	MET	I	264	9.644	−30.472	8.578	1.00	11.03	C	O
  ATOM	8833	N	PRO	I	265	7.451	−30.900	8.230	1.00	10.88	C	N
  ATOM	8834	CA	PRO	I	265	7.647	−32.293	7.841	1.00	11.09	C	C
  ATOM	8835	CB	PRO	I	265	6.215	−32.820	7.685	1.00	11.28	C	C
  ATOM	8836	CG	PRO	I	265	5.387	−31.612	7.438	1.00	11.24	C	C
  ATOM	8837	CD	PRO	I	265	6.025	−30.534	8.255	1.00	11.03	C	C
  ATOM	8838	C	PRO	I	265	8.400	−32.420	6.521	1.00	11.19	C	C
  ATOM	8839	O	PRO	I	265	7.889	−33.027	5.580	1.00	11.47	C	O
  ATOM	8840	N	ILE	I	266	9.642	−31.940	6.488	1.00	11.54	C	N
  ATOM	8841	CA	ILE	I	266	10.448	−31.980	5.266	1.00	12.15	C	C
  ATOM	8842	CB	ILE	I	266	10.586	−30.587	4.621	1.00	12.22	C	C
  ATOM	8843	CG1	ILE	I	266	11.051	−29.559	5.654	1.00	12.53	C	C
  ATOM	8844	CD1	ILE	I	266	11.557	−28.269	5.047	1.00	12.40	C	C
  ATOM	8845	CG2	ILE	I	266	9.271	−30.157	3.984	1.00	12.74	C	C
  ATOM	8846	C	ILE	I	266	11.839	−32.574	5.485	1.00	12.29	C	C
  ATOM	8847	O	ILE	I	266	12.291	−32.724	6.619	1.00	12.36	C	O
  ATOM	8848	N	THR	I	267	12.498	−32.936	4.388	1.00	12.29	C	N
  ATOM	8849	CA	THR	I	267	13.868	−33.435	4.440	1.00	12.43	C	C
  ATOM	8850	CB	THR	I	267	14.386	−33.809	3.039	1.00	12.40	C	C
  ATOM	8851	OG1	THR	I	267	15.460	−32.934	2.674	1.00	13.21	C	O
  ATOM	8852	CG2	THR	I	267	13.274	−33.699	2.010	1.00	12.21	C	C
  ATOM	8853	C	THR	I	267	14.797	−32.391	5.046	1.00	12.37	C	C
  ATOM	8854	O	THR	I	267	14.403	−31.244	5.251	1.00	12.29	C	O
  ATOM	8855	N	ASN	I	268	16.045	−32.779	5.282	1.00	12.47	C	N
  ATOM	8856	CA	ASN	I	268	16.965	−31.945	6.045	1.00	12.57	C	C
  ATOM	8857	CB	ASN	I	268	18.041	−32.800	6.715	1.00	12.69	C	C
  ATOM	8858	CG	ASN	I	268	17.682	−33.171	8.138	1.00	13.65	C	C
  ATOM	8859	OD1	ASN	I	268	16.611	−32.820	8.631	1.00	14.37	C	O
  ATOM	8860	ND2	ASN	I	268	18.569	−33.905	8.800	1.00	15.74	C	N
  ATOM	8861	C	ASN	I	268	17.608	−30.843	5.211	1.00	12.43	C	C
  ATOM	8862	O	ASN	I	268	17.775	−29.717	5.680	1.00	12.51	C	O
  ATOM	8863	N	ASP	I	269	18.038	−31.194	4.005	1.00	12.34	C	N
  ATOM	8864	CA	ASP	I	269	18.574	−30.211	3.072	1.00	12.33	C	C
  ATOM	8865	CB	ASP	I	269	19.015	−30.891	1.777	1.00	12.89	C	C
  ATOM	8866	CG	ASP	I	269	20.071	−31.950	2.007	1.00	14.84	C	C
  ATOM	8867	OD1	ASP	I	269	21.002	−31.699	2.800	1.00	16.90	C	O
  ATOM	8868	OD2	ASP	I	269	19.952	−33.047	1.422	1.00	17.65	C	O
  ATOM	8869	C	ASP	I	269	17.539	−29.138	2.769	1.00	11.60	C	C
  ATOM	8870	O	ASP	I	269	17.861	−27.952	2.696	1.00	11.65	C	O
  ATOM	8871	N	GLN	I	270	16.295	−29.564	2.585	1.00	10.62	C	N
  ATOM	8872	CA	GLN	I	270	15.182	−28.633	2.501	1.00	10.01	C	C
  ATOM	8873	CB	GLN	I	270	13.853	−29.384	2.525	1.00	10.18	C	C
  ATOM	8874	CG	GLN	I	270	12.845	−28.862	1.525	1.00	11.49	C	C
  ATOM	8875	CD	GLN	I	270	12.012	−29.968	0.918	1.00	14.38	C	C
  ATOM	8876	OE1	GLN	I	270	10.789	−29.863	0.836	1.00	16.38	C	O
  ATOM	8877	NE2	GLN	I	270	12.665	−31.057	0.530	1.00	15.41	C	N
  ATOM	8878	C	GLN	I	270	15.228	−27.620	3.636	1.00	9.48	C	C
  ATOM	8879	O	GLN	I	270	15.310	−26.415	3.400	1.00	9.12	C	O
  ATOM	8880	N	LYS	I	271	15.170	−28.112	4.868	1.00	9.19	C	N
  ATOM	8881	CA	LYS	I	271	15.211	−27.240	6.035	1.00	8.89	C	C
  ATOM	8882	CB	LYS	I	271	15.253	−28.064	7.322	1.00	8.52	C	C
  ATOM	8883	CG	LYS	I	271	13.948	−28.773	7.643	1.00	9.14	C	C
  ATOM	8884	CD	LYS	I	271	13.927	−29.280	9.076	1.00	10.72	C	C
  ATOM	8885	CE	LYS	I	271	13.274	−30.648	9.163	1.00	10.79	C	C
  ATOM	8886	NZ	LYS	I	271	12.712	−30.914	10.514	1.00	9.77	C	N
  ATOM	8887	C	LYS	I	271	16.405	−26.295	5.973	1.00	8.83	C	C
  ATOM	8888	O	LYS	I	271	16.257	−25.082	6.127	1.00	9.05	C	O
  ATOM	8889	N	LYS	I	272	17.583	−26.854	5.707	1.00	8.65	C	N
  ATOM	8890	CA	LYS	I	272	18.796	−26.058	5.548	1.00	8.50	C	C
  ATOM	8891	CB	LYS	I	272	19.977	−26.948	5.145	1.00	9.14	C	C
  ATOM	8892	CG	LYS	I	272	21.158	−26.189	4.547	1.00	11.58	C	C
  ATOM	8893	CD	LYS	I	272	22.213	−27.138	3.991	1.00	15.78	C	C
  ATOM	8894	CE	LYS	I	272	23.576	−26.464	3.891	1.00	17.65	C	C
  ATOM	8895	NZ	LYS	I	272	24.667	−27.446	3.641	1.00	19.68	C	N
  ATOM	8896	C	LYS	I	272	18.599	−24.956	4.514	1.00	7.88	C	C
  ATOM	8897	O	LYS	I	272	18.919	−23.794	4.761	1.00	8.12	C	O
  ATOM	8898	N	LEU	I	273	18.111	−25.336	3.338	1.00	6.95	C	N
  ATOM	8899	CA	LEU	I	273	17.867	−24.375	2.271	1.00	5.70	C	C
  ATOM	8900	CB	LEU	I	273	17.235	−25.063	1.060	1.00	5.85	C	C
  ATOM	8901	CG	LEU	I	273	16.754	−24.131	−0.054	1.00	4.65	C	C
  ATOM	8902	CD1	LEU	I	273	17.928	−23.571	−0.841	1.00	4.57	C	C
  ATOM	8903	CD2	LEU	I	273	15.777	−24.846	−0.972	1.00	3.69	C	C
  ATOM	8904	C	LEU	I	273	16.969	−23.244	2.755	1.00	5.14	C	C
  ATOM	8905	O	LEU	I	273	17.345	−22.074	2.702	1.00	5.25	C	O
  ATOM	8906	N	MET	I	274	15.776	−23.601	3.221	1.00	4.52	C	N
  ATOM	8907	CA	MET	I	274	14.828	−22.616	3.723	1.00	4.59	C	C
  ATOM	8908	CB	MET	I	274	13.599	−23.308	4.314	1.00	4.35	C	C
  ATOM	8909	CG	MET	I	274	12.709	−23.975	3.279	1.00	4.50	C	C
  ATOM	8910	SD	MET	I	274	11.194	−24.645	3.989	1.00	5.51	C	S
  ATOM	8911	CE	MET	I	274	10.326	−23.138	4.417	1.00	5.26	C	C
  ATOM	8912	C	MET	I	274	15.479	−21.720	4.768	1.00	5.18	C	C
  ATOM	8913	O	MET	I	274	15.279	−20.505	4.771	1.00	5.61	C	O
  ATOM	8914	N	SER	I	275	16.315	−22.319	5.610	1.00	5.89	C	N
  ATOM	8915	CA	SER	I	275	16.961	−21.588	6.688	1.00	6.18	C	C
  ATOM	8916	CB	SER	I	275	17.607	−22.555	7.682	1.00	6.33	C	C
  ATOM	8917	OG	SER	I	275	16.654	−23.470	8.193	1.00	5.91	C	O
  ATOM	8918	C	SER	I	275	17.996	−20.603	6.157	1.00	6.58	C	C
  ATOM	8919	O	SER	I	275	18.181	−19.526	6.721	1.00	7.03	C	O
  ATOM	8920	N	ASN	I	276	18.615	−20.940	5.030	1.00	7.07	C	N
  ATOM	8921	CA	ASN	I	276	19.593	−20.050	4.412	1.00	7.86	C	C
  ATOM	8922	CB	ASN	I	276	20.696	−20.854	3.711	1.00	8.34	C	C
  ATOM	8923	CG	ASN	I	276	21.868	−21.177	4.633	1.00	9.77	C	C
  ATOM	8924	OD1	ASN	I	276	22.167	−20.430	5.567	1.00	11.84	C	O
  ATOM	8925	ND2	ASN	I	276	22.557	−22.278	4.349	1.00	11.15	C	N
  ATOM	8926	C	ASN	I	276	18.976	−19.029	3.453	1.00	7.71	C	C
  ATOM	8927	O	ASN	I	276	19.695	−18.349	2.722	1.00	7.84	C	O
  ATOM	8928	N	ASN	I	277	17.655	−18.870	3.509	1.00	7.77	C	N
  ATOM	8929	CA	ASN	I	277	16.938	−18.098	2.491	1.00	7.85	C	C
  ATOM	8930	CB	ASN	I	277	16.575	−18.987	1.304	1.00	7.58	C	C
  ATOM	8931	CG	ASN	I	277	17.725	−19.157	0.335	1.00	8.29	C	C
  ATOM	8932	OD1	ASN	I	277	18.053	−18.240	−0.417	1.00	9.04	C	O
  ATOM	8933	ND2	ASN	I	277	18.427	−20.279	0.443	1.00	9.57	C	N
  ATOM	8934	C	ASN	I	277	15.697	−17.371	3.006	1.00	7.86	C	C
  ATOM	8935	O	ASN	I	277	14.826	−16.977	2.229	1.00	7.85	C	O
  ATOM	8936	N	VAL	I	278	15.593	−17.272	4.328	1.00	7.67	C	N
  ATOM	8937	CA	VAL	I	278	14.554	−16.489	4.998	1.00	7.77	C	C
  ATOM	8938	CB	VAL	I	278	15.120	−15.739	6.215	1.00	7.98	C	C
  ATOM	8939	CG1	VAL	I	278	15.116	−16.638	7.440	1.00	7.21	C	C
  ATOM	8940	CG2	VAL	I	278	16.524	−15.234	5.918	1.00	8.99	C	C
  ATOM	8941	C	VAL	I	278	13.813	−15.497	4.105	1.00	7.76	C	C
  ATOM	8942	O	VAL	I	278	12.583	−15.441	4.123	1.00	7.84	C	O
  ATOM	8943	N	GLN	I	279	14.562	−14.581	3.501	1.00	7.47	C	N
  ATOM	8944	CA	GLN	I	279	13.966	−13.446	2.809	1.00	7.07	C	C
  ATOM	8945	CB	GLN	I	279	15.038	−12.668	2.045	1.00	7.62	C	C
  ATOM	8946	CG	GLN	I	279	14.870	−11.159	2.116	1.00	10.35	C	C
  ATOM	8947	CD	GLN	I	279	15.712	−10.430	1.091	1.00	13.70	C	C
  ATOM	8948	OE1	GLN	I	279	16.199	−11.027	0.132	1.00	15.06	C	O
  ATOM	8949	NE2	GLN	I	279	15.865	−9.124	1.275	1.00	13.97	C	N
  ATOM	8950	C	GLN	I	279	12.868	−13.901	1.851	1.00	6.02	C	C
  ATOM	8951	O	GLN	I	279	11.734	−13.423	1.912	1.00	5.45	C	O
  ATOM	8952	N	ILE	I	280	13.249	−14.748	0.901	1.00	5.25	C	N
  ATOM	8953	CA	ILE	I	280	12.304	−15.343	−0.031	1.00	4.74	C	C
  ATOM	8954	CB	ILE	I	280	12.978	−16.451	−0.860	1.00	4.58	C	C
  ATOM	8955	CG1	ILE	I	280	14.333	−15.973	−1.385	1.00	4.16	C	C
  ATOM	8956	CD1	ILE	I	280	14.238	−15.065	−2.587	1.00	3.88	C	C
  ATOM	8957	CG2	ILE	I	280	12.065	−16.900	−1.996	1.00	3.92	C	C
  ATOM	8958	C	ILE	I	280	11.122	−15.946	0.716	1.00	4.43	C	C
  ATOM	8959	O	ILE	I	280	9.972	−15.547	0.516	1.00	4.39	C	O
  ATOM	8960	N	VAL	I	281	11.409	−16.970	1.513	1.00	4.05	C	N
  ATOM	8961	CA	VAL	I	281	10.390	−17.623	2.319	1.00	3.58	C	C
  ATOM	8962	CB	VAL	I	281	11.010	−18.335	3.534	1.00	3.13	C	C
  ATOM	8963	CG1	VAL	I	281	10.006	−19.291	4.158	1.00	2.34	C	C
  ATOM	8964	CG2	VAL	I	281	12.277	−19.073	3.127	1.00	2.21	C	C
  ATOM	8965	C	VAL	I	281	9.373	−16.601	2.806	1.00	3.96	C	C
  ATOM	8966	O	VAL	I	281	8.186	−16.694	2.495	1.00	4.15	C	O
  ATOM	8967	N	ARG	I	282	9.857	−15.593	3.522	1.00	4.23	C	N
  ATOM	8968	CA	ARG	I	282	8.995	−14.530	4.016	1.00	4.45	C	C
  ATOM	8969	CB	ARG	I	282	9.829	−13.427	4.656	1.00	3.96	C	C
  ATOM	8970	CG	ARG	I	282	10.637	−13.896	5.841	1.00	2.99	C	C
  ATOM	8971	CD	ARG	I	282	10.550	−12.909	6.979	1.00	2.28	C	C
  ATOM	8972	NE	ARG	I	282	11.505	−13.236	8.029	1.00	2.00	C	N
  ATOM	8973	CZ	ARG	I	282	11.175	−13.463	9.297	1.00	2.44	C	C
  ATOM	8974	NH1	ARG	I	282	9.914	−13.339	9.690	1.00	2.04	C	N
  ATOM	8975	NH2	ARG	I	282	12.099	−13.847	10.167	1.00	3.44	C	N
  ATOM	8976	C	ARG	I	282	8.144	−13.952	2.898	1.00	5.32	C	C
  ATOM	8977	O	ARG	I	282	6.924	−13.854	3.022	1.00	5.95	C	O
  ATOM	8978	N	GLN	I	283	8.794	−13.551	1.812	1.00	5.50	C	N
  ATOM	8979	CA	GLN	I	283	8.083	−12.995	0.671	1.00	5.80	C	C
  ATOM	8980	CB	GLN	I	283	9.064	−12.580	−0.421	1.00	6.19	C	C
  ATOM	8981	CG	GLN	I	283	9.908	−11.381	−0.047	1.00	9.68	C	C
  ATOM	8982	CD	GLN	I	283	11.088	−11.192	−0.971	1.00	13.92	C	C
  ATOM	8983	OE1	GLN	I	283	11.266	−11.939	−1.934	1.00	16.20	C	O
  ATOM	8984	NE2	GLN	I	283	11.885	−10.164	−0.706	1.00	14.17	C	N
  ATOM	8985	C	GLN	I	283	7.071	−13.988	0.120	1.00	5.44	C	C
  ATOM	8986	O	GLN	I	283	6.069	−13.598	−0.479	1.00	5.43	C	O
  ATOM	8987	N	GLN	I	284	7.302	−15.269	0.387	1.00	5.26	C	N
  ATOM	8988	CA	GLN	I	284	6.465	−16.321	−0.172	1.00	5.18	C	C
  ATOM	8989	CB	GLN	I	284	7.303	−17.549	−0.517	1.00	5.32	C	C
  ATOM	8990	CG	GLN	I	284	7.689	−17.619	−1.981	1.00	6.85	C	C
  ATOM	8991	CD	GLN	I	284	8.548	−18.821	−2.304	1.00	9.21	C	C
  ATOM	8992	OE1	GLN	I	284	9.398	−19.227	−1.511	1.00	9.74	C	O
  ATOM	8993	NE2	GLN	I	284	8.332	−19.400	−3.477	1.00	9.79	C	N
  ATOM	8994	C	GLN	I	284	5.345	−16.705	0.779	1.00	4.67	C	C
  ATOM	8995	O	GLN	I	284	4.485	−17.520	0.447	1.00	4.19	C	O
  ATOM	8996	N	SER	I	285	5.367	−16.116	1.968	1.00	4.51	C	N
  ATOM	8997	CA	SER	I	285	4.457	−16.516	3.027	1.00	4.39	C	C
  ATOM	8998	CB	SER	I	285	5.218	−16.729	4.336	1.00	4.13	C	C
  ATOM	8999	OG	SER	I	285	6.328	−17.588	4.146	1.00	4.40	C	O
  ATOM	9000	C	SER	I	285	3.359	−15.481	3.220	1.00	4.44	C	C
  ATOM	9001	O	SER	I	285	3.483	−14.335	2.785	1.00	4.82	C	O
  ATOM	9002	N	TYR	I	286	2.268	−15.908	3.842	1.00	4.53	C	N
  ATOM	9003	CA	TYR	I	286	1.194	−15.002	4.213	1.00	4.80	C	C
  ATOM	9004	CB	TYR	I	286	−0.116	−15.441	3.559	1.00	4.88	C	C
  ATOM	9005	CG	TYR	I	286	−0.135	−15.272	2.059	1.00	5.68	C	C
  ATOM	9006	CD1	TYR	I	286	0.713	−16.013	1.245	1.00	7.34	C	C
  ATOM	9007	CE1	TYR	I	286	0.695	−15.864	−0.126	1.00	9.02	C	C
  ATOM	9008	CZ	TYR	I	286	−0.190	−14.979	−0.701	1.00	9.40	C	C
  ATOM	9009	OH	TYR	I	286	−0.206	−14.824	−2.066	1.00	10.44	C	O
  ATOM	9010	CE2	TYR	I	286	−1.054	−14.244	0.083	1.00	9.38	C	C
  ATOM	9011	CD2	TYR	I	286	−1.024	−14.395	1.453	1.00	7.39	C	C
  ATOM	9012	C	TYR	I	286	1.037	−14.978	5.726	1.00	4.76	C	C
  ATOM	9013	O	TYR	I	286	1.499	−15.883	6.421	1.00	5.25	C	O
  ATOM	9014	N	SER	I	287	0.403	−13.929	6.234	1.00	4.52	C	N
  ATOM	9015	CA	SER	I	287	−0.072	−13.924	7.609	1.00	4.45	C	C
  ATOM	9016	CB	SER	I	287	0.779	−12.989	8.470	1.00	4.57	C	C
  ATOM	9017	OG	SER	I	287	0.113	−12.662	9.678	1.00	4.38	C	O
  ATOM	9018	C	SER	I	287	−1.535	−13.516	7.675	1.00	4.61	C	C
  ATOM	9019	O	SER	I	287	−1.920	−12.460	7.172	1.00	4.40	C	O
  ATOM	9020	N	ILE	I	288	−2.364	−14.425	8.171	1.00	5.11	C	N
  ATOM	9021	CA	ILE	I	288	−3.788	−14.171	8.302	1.00	5.81	C	C
  ATOM	9022	CB	ILE	I	288	−4.610	−15.393	7.863	1.00	5.52	C	C
  ATOM	9023	CG1	ILE	I	288	−3.811	−16.253	6.878	1.00	5.47	C	C
  ATOM	9024	CD1	ILE	I	288	−3.975	−15.852	5.429	1.00	6.23	C	C
  ATOM	9025	CG2	ILE	I	288	−5.939	−14.957	7.271	1.00	6.22	C	C
  ATOM	9026	C	ILE	I	288	−4.123	−13.848	9.750	1.00	6.71	C	C
  ATOM	9027	O	ILE	I	288	−3.759	−14.593	10.660	1.00	7.30	C	O
  ATOM	9028	N	MET	I	289	−4.874	−12.771	9.952	1.00	7.71	C	N
  ATOM	9029	CA	MET	I	289	−5.451	−12.476	11.257	1.00	8.57	C	C
  ATOM	9030	CB	MET	I	289	−6.099	−11.090	11.246	1.00	8.71	C	C
  ATOM	9031	CG	MET	I	289	−6.131	−10.412	12.603	1.00	9.70	C	C
  ATOM	9032	SD	MET	I	289	−7.100	−8.895	12.581	1.00	12.59	C	S
  ATOM	9033	CE	MET	I	289	−8.569	−9.452	11.721	1.00	12.41	C	C
  ATOM	9034	C	MET	I	289	−6.477	−13.538	11.658	1.00	9.12	C	C
  ATOM	9035	O	MET	I	289	−7.322	−13.925	10.851	1.00	9.31	C	O
  ATOM	9036	N	SER	I	290	−6.406	−13.998	12.907	1.00	9.80	C	N
  ATOM	9037	CA	SER	I	290	−7.290	−15.062	13.388	1.00	10.49	C	C
  ATOM	9038	CB	SER	I	290	−6.494	−16.195	14.035	1.00	10.64	C	C
  ATOM	9039	OG	SER	I	290	−7.316	−17.328	14.257	1.00	11.99	C	O
  ATOM	9040	C	SER	I	290	−8.385	−14.573	14.335	1.00	10.75	C	C
  ATOM	9041	O	SER	I	290	−9.563	−14.595	13.980	1.00	10.89	C	O
  ATOM	9042	N	ILE	I	291	−8.018	−14.243	15.571	1.00	11.04	C	N
  ATOM	9043	CA	ILE	I	291	−8.955	−13.562	16.461	1.00	11.41	C	C
  ATOM	9044	CB	ILE	I	291	−9.796	−14.539	17.305	1.00	11.80	C	C
  ATOM	9045	CG1	ILE	I	291	−9.096	−15.893	17.419	1.00	11.81	C	C
  ATOM	9046	CD1	ILE	I	291	−8.227	−16.028	18.647	1.00	11.76	C	C
  ATOM	9047	CG2	ILE	I	291	−11.179	−14.707	16.700	1.00	12.39	C	C
  ATOM	9048	C	ILE	I	291	−8.349	−12.481	17.346	1.00	11.13	C	C
  ATOM	9049	O	ILE	I	291	−7.316	−12.681	17.986	1.00	10.55	C	O
  ATOM	9050	N	ILE	I	292	−9.034	−11.343	17.398	1.00	11.36	C	N
  ATOM	9051	CA	ILE	I	292	−8.605	−10.215	18.211	1.00	11.82	C	C
  ATOM	9052	CB	ILE	I	292	−8.651	−8.884	17.421	1.00	11.86	C	C
  ATOM	9053	CG1	ILE	I	292	−9.052	−9.127	15.963	1.00	13.42	C	C
  ATOM	9054	CD1	ILE	I	292	−7.968	−9.771	15.126	1.00	15.86	C	C
  ATOM	9055	CG2	ILE	I	292	−7.311	−8.160	17.508	1.00	10.85	C	C
  ATOM	9056	C	ILE	I	292	−9.486	−10.092	19.444	1.00	11.72	C	C
  ATOM	9057	O	ILE	I	292	−10.713	−10.029	19.346	1.00	11.28	C	O
  ATOM	9058	N	LYS	I	293	−8.857	−10.180	20.607	1.00	12.11	C	N
  ATOM	9059	CA	LYS	I	293	−9.479	−9.728	21.834	1.00	12.92	C	C
  ATOM	9060	CB	LYS	I	293	−9.599	−10.889	22.820	1.00	13.15	C	C
  ATOM	9061	CG	LYS	I	293	−10.034	−12.194	22.174	1.00	14.17	C	C
  ATOM	9062	CD	LYS	I	293	−10.958	−12.974	23.091	1.00	15.37	C	C
  ATOM	9063	CE	LYS	I	293	−11.869	−13.899	22.305	1.00	16.68	C	C
  ATOM	9064	NZ	LYS	I	293	−12.822	−14.614	23.197	1.00	18.18	C	N
  ATOM	9065	C	LYS	I	293	−8.670	−8.584	22.433	1.00	13.32	C	C
  ATOM	9066	O	LYS	I	293	−7.518	−8.366	22.055	1.00	13.17	C	O
  ATOM	9067	N	GLU	I	294	−9.337	−7.759	23.233	1.00	14.07	C	N
  ATOM	9068	CA	GLU	I	294	−8.714	−6.572	23.805	1.00	15.07	C	C
  ATOM	9069	CB	GLU	I	294	−9.608	−5.975	24.896	1.00	15.94	C	C
  ATOM	9070	CG	GLU	I	294	−10.872	−5.307	24.373	1.00	19.87	C	C
  ATOM	9071	CD	GLU	I	294	−11.569	−4.471	25.427	1.00	23.88	C	C
  ATOM	9072	OE1	GLU	I	294	−10.994	−3.449	25.854	1.00	23.75	C	O
  ATOM	9073	OE2	GLU	I	294	−12.723	−4.799	25.777	1.00	25.81	C	O
  ATOM	9074	C	GLU	I	294	−7.324	−6.878	24.362	1.00	14.40	C	C
  ATOM	9075	O	GLU	I	294	−6.433	−6.031	24.319	1.00	14.33	C	O
  ATOM	9076	N	GLU	I	295	−7.144	−8.092	24.879	1.00	13.97	C	N
  ATOM	9077	CA	GLU	I	295	−5.908	−8.452	25.568	1.00	13.84	C	C
  ATOM	9078	CB	GLU	I	295	−6.161	−8.721	27.055	1.00	14.67	C	C
  ATOM	9079	CG	GLU	I	295	−7.620	−8.914	27.427	1.00	17.56	C	C
  ATOM	9080	CD	GLU	I	295	−8.245	−10.112	26.743	1.00	21.41	C	C
  ATOM	9081	OE1	GLU	I	295	−8.990	−9.909	25.761	1.00	22.35	C	O
  ATOM	9082	OE2	GLU	I	295	−8.090	−11.241	27.257	1.00	23.20	C	O
  ATOM	9083	C	GLU	I	295	−5.166	−9.630	24.933	1.00	12.77	C	C
  ATOM	9084	O	GLU	I	295	−4.166	−10.100	25.476	1.00	12.58	C	O
  ATOM	9085	N	VAL	I	296	−5.701	−10.162	23.838	1.00	11.72	C	N
  ATOM	9086	CA	VAL	I	296	−4.970	−11.150	23.051	1.00	10.65	C	C
  ATOM	9087	CB	VAL	I	296	−5.245	−12.589	23.517	1.00	10.47	C	C
  ATOM	9088	CG1	VAL	I	296	−4.277	−13.546	22.846	1.00	9.77	C	C
  ATOM	9089	CG2	VAL	I	296	−5.118	−12.688	25.026	1.00	11.31	C	C
  ATOM	9090	C	VAL	I	296	−5.245	−11.039	21.562	1.00	10.26	C	C
  ATOM	9091	O	VAL	I	296	−6.395	−10.940	21.133	1.00	10.09	C	O
  ATOM	9092	N	LEU	I	297	−4.184	−11.178	20.777	1.00	9.77	C	N
  ATOM	9093	CA	LEU	I	297	−4.302	−11.269	19.332	1.00	8.97	C	C
  ATOM	9094	CB	LEU	I	297	−3.577	−10.097	18.672	1.00	8.64	C	C
  ATOM	9095	CG	LEU	I	297	−3.382	−10.209	17.160	1.00	9.01	C	C
  ATOM	9096	CD1	LEU	I	297	−4.721	−10.384	16.459	1.00	9.79	C	C
  ATOM	9097	CD2	LEU	I	297	−2.645	−8.994	16.620	1.00	9.43	C	C
  ATOM	9098	C	LEU	I	297	−3.725	−12.587	18.829	1.00	8.34	C	C
  ATOM	9099	O	LEU	I	297	−2.565	−12.908	19.089	1.00	8.64	C	O
  ATOM	9100	N	ALA	I	298	−4.545	−13.352	18.116	1.00	7.21	C	N
  ATOM	9101	CA	ALA	I	298	−4.095	−14.600	17.515	1.00	6.33	C	C
  ATOM	9102	CB	ALA	I	298	−4.908	−15.770	18.047	1.00	6.68	C	C
  ATOM	9103	C	ALA	I	298	−4.207	−14.524	16.002	1.00	5.85	C	C
  ATOM	9104	O	ALA	I	298	−5.179	−13.991	15.468	1.00	5.96	C	O
  ATOM	9105	N	TYR	I	299	−3.197	−15.040	15.314	1.00	5.28	C	N
  ATOM	9106	CA	TYR	I	299	−3.197	−15.042	13.861	1.00	4.63	C	C
  ATOM	9107	CB	TYR	I	299	−2.583	−13.749	13.324	1.00	4.36	C	C
  ATOM	9108	CG	TYR	I	299	−1.177	−13.490	13.812	1.00	4.34	C	C
  ATOM	9109	CD1	TYR	I	299	−0.080	−13.970	13.110	1.00	4.48	C	C
  ATOM	9110	CE1	TYR	I	299	1.207	−13.733	13.549	1.00	4.55	C	C
  ATOM	9111	CZ	TYR	I	299	1.409	−13.011	14.705	1.00	3.72	C	C
  ATOM	9112	OH	TYR	I	299	2.690	−12.775	15.149	1.00	2.38	C	O
  ATOM	9113	CE2	TYR	I	299	0.336	−12.526	15.422	1.00	4.13	C	C
  ATOM	9114	CD2	TYR	I	299	−0.947	−12.767	14.975	1.00	4.38	C	C
  ATOM	9115	C	TYR	I	299	−2.440	−16.243	13.322	1.00	4.32	C	C
  ATOM	9116	O	TYR	I	299	−1.602	−16.822	14.012	1.00	4.67	C	O
  ATOM	9117	N	VAL	I	300	−2.746	−16.622	12.087	1.00	3.87	C	N
  ATOM	9118	CA	VAL	I	300	−2.130	−17.792	11.486	1.00	3.57	C	C
  ATOM	9119	CB	VAL	I	300	−3.169	−18.702	10.805	1.00	3.52	C	C
  ATOM	9120	CG1	VAL	I	300	−2.475	−19.749	9.943	1.00	3.44	C	C
  ATOM	9121	CG2	VAL	I	300	−4.053	−19.368	11.851	1.00	3.90	C	C
  ATOM	9122	C	VAL	I		300	−1.060	−17.392	10.482	1.00	3.53	C	C
  ATOM	9123	O	VAL	I		300	−1.299	−16.575	9.593	1.00	3.68	C	O
  ATOM	9124	N	VAL	I	301	0.148	−17.899	10.695	1.00	3.41	C	N
  ATOM	9125	CA	VAL	I	301	1.193	−17.816	9.689	1.00	3.36	C	C
  ATOM	9126	CB	VAL	I	301	2.593	−17.825	10.324	1.00	3.24	C	C
  ATOM	9127	CG1	VAL	I	301	3.655	−18.061	9.261	1.00	3.76	C	C
  ATOM	9128	CG2	VAL	I	301	2.849	−16.519	11.059	1.00	3.10	C	C
  ATOM	9129	C	VAL	I	301	1.084	−18.962	8.695	1.00	3.48	C	C
  ATOM	9130	O	VAL	I	301	0.647	−20.061	9.037	1.00	3.92	C	O
  ATOM	9131	N	GLN	I	302	1.466	−18.684	7.456	1.00	3.21	C	N
  ATOM	9132	CA	GLN	I	302	1.274	−19.625	6.368	1.00	3.01	C	C
  ATOM	9133	CB	GLN	I	302	0.090	−19.202	5.504	1.00	3.24	C	C
  ATOM	9134	CG	GLN	I	302	−0.067	−20.021	4.239	1.00	5.21	C	C
  ATOM	9135	CD	GLN	I	302	−1.479	−19.984	3.701	1.00	7.54	C	C
  ATOM	9136	OE1	GLN	I	302	−2.435	−19.784	4.449	1.00	7.28	C	O
  ATOM	9137	NE2	GLN	I	302	−1.616	−20.143	2.390	1.00	9.27	C	N
  ATOM	9138	C	GLN	I	302	2.533	−19.693	5.523	1.00	2.42	C	C
  ATOM	9139	O	GLN	I	302	2.881	−18.736	4.832	1.00	2.40	C	O
  ATOM	9140	N	LEU	I	303	3.292	−20.765	5.707	1.00	2.00	C	N
  ATOM	9141	CA	LEU	I	303	4.607	−20.868	5.104	1.00	2.00	C	C
  ATOM	9142	CB	LEU	I	303	5.628	−21.358	6.130	1.00	2.00	C	C
  ATOM	9143	CG	LEU	I	303	5.663	−20.559	7.434	1.00	2.00	C	C
  ATOM	9144	CD1	LEU	I	303	6.712	−21.118	8.382	1.00	2.00	C	C
  ATOM	9145	CD2	LEU	I	303	5.918	−19.085	7.154	1.00	2.00	C	C
  ATOM	9146	C	LEU	I	303	4.564	−21.805	3.909	1.00	2.00	C	C
  ATOM	9147	O	LEU	I	303	3.658	−22.630	3.794	1.00	2.45	C	O
  ATOM	9148	N	PRO	I	304	5.499	−21.620	2.970	1.00	2.00	C	N
  ATOM	9149	CA	PRO	I	304	5.617	−22.519	1.840	1.00	2.07	C	C
  ATOM	9150	CB	PRO	I	304	6.326	−21.656	0.803	1.00	2.00	C	C
  ATOM	9151	CG	PRO	I	304	7.221	−20.775	1.620	1.00	2.00	C	C
  ATOM	9152	CD	PRO	I	304	6.564	−20.601	2.973	1.00	2.06	C	C
  ATOM	9153	C	PRO	I	304	6.492	−23.711	2.194	1.00	2.11	C	C
  ATOM	9154	O	PRO	I	304	7.544	−23.530	2.809	1.00	2.13	C	O
  ATOM	9155	N	ALA	I	305	5.903	−24.902	2.097	1.00	30.00	C	N
  ATOM	9156	CA	ALA	I	305	6.371	−25.959	1.180	1.00	30.00	C	C
  ATOM	9157	CB	ALA	I	305	5.841	−27.314	1.627	1.00	30.00	C	C
  ATOM	9158	C	ALA	I	305	6.011	−25.690	−0.310	1.00	30.00	C	C
  ATOM	9159	O	ALA	I	305	5.614	−24.571	−0.624	1.00	30.00	C	O
  ATOM	9160	N	TYR	I	306	5.840	−26.756	−1.125	1.00	13.49	C	N
  ATOM	9161	CA	TYR	I	306	6.433	−26.943	−2.522	1.00	13.70	C	C
  ATOM	9162	CB	TYR	I	306	7.412	−28.117	−2.435	1.00	13.93	C	C
  ATOM	9163	CG	TYR	I	306	8.486	−28.217	−3.491	1.00	14.08	C	C
  ATOM	9164	CD1	TYR	I	306	8.717	−29.447	−4.102	1.00	14.59	C	C
  ATOM	9165	CE1	TYR	I	306	9.982	−29.819	−4.531	1.00	14.82	C	C
  ATOM	9166	CZ	TYR	I	306	11.002	−28.893	−4.523	1.00	14.52	C	C
  ATOM	9167	OH	TYR	I	306	12.189	−29.164	−5.167	1.00	13.02	C	O
  ATOM	9168	CE2	TYR	I	306	10.781	−27.632	−4.011	1.00	15.22	C	C
  ATOM	9169	CD2	TYR	I	306	9.534	−27.303	−3.495	1.00	14.61	C	C
  ATOM	9170	C	TYR	I	306	5.391	−27.297	−3.661	1.00	13.68	C	C
  ATOM	9171	O	TYR	I	306	4.296	−27.738	−3.325	1.00	13.95	C	O
  ATOM	9172	N	GLY	I	307	5.786	−27.316	−4.962	1.00	13.54	C	N
  ATOM	9173	CA	GLY	I	307	5.057	−28.108	−6.046	1.00	13.37	C	C
  ATOM	9174	C	GLY	I	307	5.290	−27.995	−7.585	1.00	13.47	C	C
  ATOM	9175	O	GLY	I	307	5.871	−27.017	−8.054	1.00	13.90	C	O
  ATOM	9176	N	VAL	I	308	4.808	−28.976	−8.370	1.00	13.31	C	N
  ATOM	9177	CA	VAL	I	308	3.931	−28.717	−9.548	1.00	13.30	C	C
  ATOM	9178	CB	VAL	I	308	3.187	−27.383	−9.404	1.00	13.03	C	C
  ATOM	9179	CG1	VAL	I	308	1.935	−27.380	−10.261	1.00	13.62	C	C
  ATOM	9180	CG2	VAL	I	308	2.849	−27.116	−7.951	1.00	12.86	C	C
  ATOM	9181	C	VAL	I	308	4.596	−28.668	−10.927	1.00	13.58	C	C
  ATOM	9182	O	VAL	I	308	5.407	−29.530	−11.271	1.00	13.71	C	O
  ATOM	9183	N	ILE	I	309	4.541	−27.470	−11.498	1.00	4.08	C	N
  ATOM	9184	CA	ILE	I	309	5.611	−26.532	−11.251	1.00	4.84	C	C
  ATOM	9185	CB	ILE	I	309	6.204	−26.810	−9.854	1.00	4.89	C	C
  ATOM	9186	CG1	ILE	I	309	5.086	−26.815	−8.801	1.00	5.85	C	C
  ATOM	9187	CD1	ILE	I	309	4.233	−25.561	−8.803	1.00	8.12	C	C
  ATOM	9188	CG2	ILE	I	309	7.308	−25.817	−9.517	1.00	4.44	C	C
  ATOM	9189	C	ILE	I	309	6.637	−26.814	−12.345	1.00	5.23	C	C
  ATOM	9190	O	ILE	I	309	6.299	−27.437	−13.352	1.00	5.92	C	O
  ATOM	9191	N	ASP	I	310	7.864	−26.330	−12.187	1.00	5.33	C	N
  ATOM	9192	CA	ASP	I	310	9.004	−26.924	−12.889	1.00	5.83	C	C
  ATOM	9193	CB	ASP	I	310	9.086	−28.423	−12.589	1.00	6.21	C	C
  ATOM	9194	CG	ASP	I	310	9.193	−28.716	−11.104	1.00	7.19	C	C
  ATOM	9195	OD1	ASP	I	310	8.350	−29.478	−10.583	1.00	7.74	C	O
  ATOM	9196	OD2	ASP	I	310	10.151	−28.228	−10.467	1.00	7.58	C	O
  ATOM	9197	C	ASP	I	310	8.997	−26.705	−14.408	1.00	6.02	C	C
  ATOM	9198	O	ASP	I	310	9.656	−27.438	−15.146	1.00	6.05	C	O
  ATOM	9199	N	THR	I	311	8.273	−25.687	−14.866	1.00	6.24	C	N
  ATOM	9200	CA	THR	I	311	8.429	−25.173	−16.229	1.00	6.14	C	C
  ATOM	9201	CB	THR	I	311	7.231	−24.299	−16.630	1.00	5.69	C	C
  ATOM	9202	OG1	THR	I	311	6.093	−24.646	−15.830	1.00	5.34	C	O
  ATOM	9203	CG2	THR	I	311	6.897	−24.500	−18.092	1.00	7.10	C	C
  ATOM	9204	C	THR	I	311	9.682	−24.313	−16.335	1.00	6.78	C	C
  ATOM	9205	O	THR	I	311	9.970	−23.530	−15.430	1.00	7.33	C	O
  ATOM	9206	N	PRO	I	312	10.330	−24.318	−17.509	1.00	7.00	C	N
  ATOM	9207	CA	PRO	I	312	11.470	−23.419	−17.668	1.00	7.23	C	C
  ATOM	9208	CB	PRO	I	312	12.060	−23.834	−19.020	1.00	7.00	C	C
  ATOM	9209	CG	PRO	I	312	10.936	−24.505	−19.747	1.00	6.59	C	C
  ATOM	9210	CD	PRO	I	312	10.098	−25.159	−18.697	1.00	6.99	C	C
  ATOM	9211	C	PRO	I	312	11.016	−21.962	−17.703	1.00	7.69	C	C
  ATOM	9212	O	PRO	I	312	9.943	−21.670	−18.228	1.00	7.55	C	O
  ATOM	9213	N	CYS	I	313	11.755	−21.077	−17.041	1.00	8.10	C	N
  ATOM	9214	CA	CYS	I	313	11.668	−19.654	−17.353	1.00	8.54	C	C
  ATOM	9215	CB	CYS	I	313	11.082	−18.852	−16.186	1.00	8.77	C	C
  ATOM	9216	SG	CYS	I	313	10.025	−19.785	−15.057	1.00	10.74	C	S
  ATOM	9217	C	CYS	I	313	13.000	−19.058	−17.780	1.00	8.19	C	C
  ATOM	9218	O	CYS	I	313	14.035	−19.725	−17.760	1.00	8.07	C	O
  ATOM	9219	N	TRP	I	314	12.964	−17.777	−18.126	1.00	7.93	C	N
  ATOM	9220	CA	TRP	I	314	14.162	−17.035	−18.473	1.00	7.80	C	C
  ATOM	9221	CB	TRP	I	314	14.563	−17.322	−19.919	1.00	8.13	C	C
  ATOM	9222	CG	TRP	I	314	13.457	−17.091	−20.902	1.00	9.09	C	C
  ATOM	9223	CD1	TRP	I	314	13.295	−16.003	−21.710	1.00	10.26	C	C
  ATOM	9224	NE1	TRP	I	314	12.219	−16.189	−22.546	1.00	10.86	C	N
  ATOM	9225	CE2	TRP	I	314	11.671	−17.421	−22.298	1.00	10.68	C	C
  ATOM	9226	CD2	TRP	I	314	12.426	−18.020	−21.269	1.00	10.49	C	C
  ATOM	9227	CE3	TRP	I	314	12.083	−19.308	−20.842	1.00	11.67	C	C
  ATOM	9228	CZ3	TRP	I	314	11.009	−19.946	−21.447	1.00	12.98	C	C
  ATOM	9229	CH2	TRP	I	314	10.268	−19.318	−22.457	1.00	12.74	C	C
  ATOM	9230	CZ2	TRP	I	314	10.580	−18.059	−22.895	1.00	11.73	C	C
  ATOM	9231	C	TRP	I	314	13.899	−15.550	−18.298	1.00	7.34	C	C
  ATOM	9232	O	TRP	I	314	12.764	−15.091	−18.427	1.00	7.47	C	O
  ATOM	9233	N	LYS	I	315	14.936	−14.815	−17.920	1.00	6.75	C	N
  ATOM	9234	CA	LYS	I	315	14.833	−13.372	−17.823	1.00	6.37	C	C
  ATOM	9235	CB	LYS	I	315	15.493	−12.875	−16.541	1.00	6.38	C	C
  ATOM	9236	CG	LYS	I	315	14.992	−11.522	−16.065	1.00	6.55	C	C
  ATOM	9237	CD	LYS	I	315	15.692	−11.117	−14.778	1.00	8.01	C	C
  ATOM	9238	CE	LYS	I	315	15.198	−9.776	−14.269	1.00	8.78	C	C
  ATOM	9239	NZ	LYS	I	315	16.141	−9.189	−13.276	1.00	10.21	C	N
  ATOM	9240	C	LYS	I	315	15.468	−12.711	−19.036	1.00	6.32	C	C
  ATOM	9241	O	LYS	I	315	16.510	−13.153	−19.523	1.00	6.21	C	O
  ATOM	9242	N	LEU	I	316	14.766	−11.724	−19.584	1.00	6.58	C	N
  ATOM	9243	CA	LEU	I	316	15.231	−10.992	−20.758	1.00	7.02	C	C
  ATOM	9244	CB	LEU	I	316	14.122	−10.908	−21.809	1.00	6.64	C	C
  ATOM	9245	CG	LEU	I	316	14.308	−9.874	−22.922	1.00	6.21	C	C
  ATOM	9246	CD1	LEU	I	316	15.563	−10.150	−23.731	1.00	5.94	C	C
  ATOM	9247	CD2	LEU	I	316	13.082	−9.824	−23.819	1.00	6.57	C	C
  ATOM	9248	C	LEU	I	316	15.675	−9.588	−20.372	1.00	7.77	C	C
  ATOM	9249	O	LEU	I	316	14.865	−8.768	−19.941	1.00	8.47	C	O
  ATOM	9250	N	HIS	I	317	16.956	−9.302	−20.563	1.00	8.05	C	N
  ATOM	9251	CA	HIS	I	317	17.422	−7.929	−20.547	1.00	8.21	C	C
  ATOM	9252	CB	HIS	I	317	18.641	−7.786	−19.640	1.00	9.04	C	C
  ATOM	9253	CG	HIS	I	317	18.644	−8.734	−18.483	1.00	11.41	C	C
  ATOM	9254	ND1	HIS	I	317	18.314	−8.347	−17.202	1.00	13.62	C	N
  ATOM	9255	CE1	HIS	I	317	18.423	−9.383	−16.389	1.00	14.91	C	C
  ATOM	9256	NE2	HIS	I	317	18.811	−10.428	−17.097	1.00	14.25	C	N
  ATOM	9257	CD2	HIS	I	317	18.960	−10.048	−18.409	1.00	12.67	C	C
  ATOM	9258	C	HIS	I	317	17.760	−7.469	−21.950	1.00	7.39	C	C
  ATOM	9259	O	HIS	I	317	17.881	−8.278	−22.869	1.00	7.23	C	O
  ATOM	9260	N	THR	I	318	17.997	−6.172	−22.086	1.00	7.11	C	N
  ATOM	9261	CA	THR	I	318	17.745	−5.476	−23.333	1.00	6.56	C	C
  ATOM	9262	CB	THR	I	318	16.268	−5.093	−23.468	1.00	6.28	C	C
  ATOM	9263	OG1	THR	I	318	15.652	−5.909	−24.471	1.00	6.33	C	O
  ATOM	9264	CG2	THR	I	318	16.141	−3.634	−23.866	1.00	6.52	C	C
  ATOM	9265	C	THR	I	318	18.563	−4.201	−23.357	1.00	6.58	C	C
  ATOM	9266	O	THR	I	318	18.437	−3.356	−22.472	1.00	6.67	C	O
  ATOM	9267	N	SER	I	319	19.378	−4.044	−24.390	1.00	6.81	C	N
  ATOM	9268	CA	SER	I	319	20.173	−2.837	−24.533	1.00	7.31	C	C
  ATOM	9269	CB	SER	I	319	21.633	−3.105	−24.159	1.00	7.14	C	C
  ATOM	9270	OG	SER	I	319	22.309	−1.904	−23.825	1.00	6.84	C	O
  ATOM	9271	C	SER	I	319	20.069	−2.273	−25.945	1.00	7.93	C	C
  ATOM	9272	O	SER	I	319	19.736	−2.996	−26.887	1.00	8.65	C	O
  ATOM	9273	N	PRO	I	320	20.242	−0.952	−26.075	1.00	8.08	C	N
  ATOM	9274	CA	PRO	I	320	20.052	−0.299	−27.363	1.00	8.34	C	C
  ATOM	9275	CB	PRO	I	320	20.263	1.187	−27.047	1.00	7.99	C	C
  ATOM	9276	CG	PRO	I	320	20.887	1.228	−25.680	1.00	8.01	C	C
  ATOM	9277	CD	PRO	I	320	20.384	0.015	−24.977	1.00	8.10	C	C
  ATOM	9278	C	PRO	I	320	21.061	−0.770	−28.400	1.00	9.03	C	C
  ATOM	9279	O	PRO	I	320	22.135	−1.262	−28.053	1.00	8.74	C	O
  ATOM	9280	N	LEU	I	321	20.711	−0.594	−29.669	1.00	10.31	C	N
  ATOM	9281	CA	LEU	I	321	21.427	−1.228	−30.766	1.00	11.63	C	C
  ATOM	9282	CB	LEU	I	321	20.792	−2.576	−31.105	1.00	11.31	C	C
  ATOM	9283	CG	LEU	I	321	21.681	−3.600	−31.812	1.00	10.97	C	C
  ATOM	9284	CD1	LEU	I	321	20.835	−4.621	−32.549	1.00	10.04	C	C
  ATOM	9285	CD2	LEU	I	321	22.652	−2.914	−32.761	1.00	10.69	C	C
  ATOM	9286	C	LEU	I	321	21.412	−0.317	−31.989	1.00	12.92	C	C
  ATOM	9287	O	LEU	I	321	20.351	0.114	−32.441	1.00	13.29	C	O
  ATOM	9288	N	CYS	I	322	22.601	0.013	−32.486	1.00	13.39	C	N
  ATOM	9289	CA	CYS	I	322	22.751	0.987	−33.563	1.00	14.16	C	C
  ATOM	9290	CB	CYS	I	322	23.359	2.288	−33.036	1.00	13.72	C	C
  ATOM	9291	SG	CYS	I	322	22.632	2.898	−31.504	1.00	13.42	C	S
  ATOM	9292	C	CYS	I	322	23.622	0.441	−34.690	1.00	15.46	C	C
  ATOM	9293	O	CYS	I	322	24.646	−0.196	−34.446	1.00	15.94	C	O
  ATOM	9294	N	THR	I	323	23.265	0.802	−35.919	1.00	16.70	C	N
  ATOM	9295	CA	THR	I	323	24.152	0.675	−37.075	1.00	17.84	C	C
  ATOM	9296	CB	THR	I	323	23.429	1.117	−38.359	1.00	17.50	C	C
  ATOM	9297	OG1	THR	I	323	22.416	2.076	−38.031	1.00	15.70	C	O
  ATOM	9298	CG2	THR	I	323	22.786	−0.076	−39.047	1.00	18.05	C	C
  ATOM	9299	C	THR	I	323	25.403	1.536	−36.918	1.00	19.54	C	C
  ATOM	9300	O	THR	I	323	25.408	2.477	−36.124	1.00	19.84	C	O
  ATOM	9301	N	THR	I	324	26.352	1.379	−37.840	1.00	21.17	C	N
  ATOM	9302	CA	THR	I	324	27.430	2.358	−37.967	1.00	22.89	C	C
  ATOM	9303	CB	THR	I	324	28.687	1.950	−37.188	1.00	22.69	C	C
  ATOM	9304	OG1	THR	I	324	28.403	0.800	−36.381	1.00	22.10	C	O
  ATOM	9305	CG2	THR	I	324	29.150	3.094	−36.300	1.00	22.03	C	C
  ATOM	9306	C	THR	I	324	27.815	2.806	−39.378	1.00	24.39	C	C
  ATOM	9307	O	THR	I	324	28.495	3.820	−39.537	1.00	24.53	C	O
  ATOM	9308	N	ASN	I	325	27.330	2.106	−40.398	1.00	25.72	C	N
  ATOM	9309	CA	ASN	I	325	27.321	2.661	−41.751	1.00	27.01	C	C
  ATOM	9310	CB	ASN	I	325	28.628	2.344	−42.484	1.00	27.37	C	C
  ATOM	9311	CG	ASN	I	325	29.720	3.360	−42.199	1.00	28.46	C	C
  ATOM	9312	OD1	ASN	I	325	29.982	4.252	−43.007	1.00	30.37	C	O
  ATOM	9313	ND2	ASN	I	325	30.364	3.229	−41.045	1.00	28.78	C	N
  ATOM	9314	C	ASN	I	325	26.125	2.199	−42.576	1.00	27.36	C	C
  ATOM	9315	O	ASN	I	325	25.455	1.228	−42.226	1.00	27.94	C	O
  ATOM	9316	N	SER	I	330	24.776	3.883	−38.461	1.00	35.76	C	N
  ATOM	9317	CA	SER	I	330	24.479	5.303	−38.606	1.00	35.01	C	C
  ATOM	9318	CB	SER	I	330	24.922	5.803	−39.983	1.00	35.47	C	C
  ATOM	9319	OG	SER	I	330	24.296	5.067	−41.019	1.00	33.31	C	O
  ATOM	9320	C	SER	I	330	22.992	5.574	−38.405	1.00	34.35	C	C
  ATOM	9321	O	SER	I	330	22.148	4.769	−38.798	1.00	34.33	C	O
  ATOM	9322	N	ASN	I	331	22.677	6.688	−37.752	1.00	32.48	C	N
  ATOM	9323	CA	ASN	I	331	21.365	7.314	−37.886	1.00	30.72	C	C
  ATOM	9324	CB	ASN	I	331	21.065	7.642	−39.357	1.00	31.31	C	C
  ATOM	9325	CG	ASN	I	331	21.961	8.740	−39.916	1.00	32.11	C	C
  ATOM	9326	OD1	ASN	I	331	22.615	9.469	−39.170	1.00	32.54	C	O
  ATOM	9327	ND2	ASN	I	331	21.941	8.901	−41.235	1.00	31.30	C	N
  ATOM	9328	C	ASN	I	331	20.188	6.532	−37.282	1.00	28.71	C	C
  ATOM	9329	O	ASN	I	331	19.038	6.940	−37.444	1.00	29.07	C	O
  ATOM	9330	N	ILE	I	332	20.450	5.399	−36.629	1.00	25.44	C	N
  ATOM	9331	CA	ILE	I	332	19.354	4.517	−36.200	1.00	21.83	C	C
  ATOM	9332	CB	ILE	I	332	18.777	3.711	−37.387	1.00	21.42	C	C
  ATOM	9333	CG1	ILE	I	332	17.534	2.929	−36.961	1.00	19.89	C	C
  ATOM	9334	CD1	ILE	I	332	16.273	3.385	−37.652	1.00	17.67	C	C
  ATOM	9335	CG2	ILE	I	332	19.828	2.777	−37.965	1.00	20.61	C	C
  ATOM	9336	C	ILE	I	332	19.679	3.570	−35.035	1.00	20.37	C	C
  ATOM	9337	O	ILE	I	332	20.593	2.751	−35.134	1.00	19.95	C	O
  ATOM	9338	N	CYS	I	333	18.816	3.561	−34.019	1.00	18.27	C	N
  ATOM	9339	CA	CYS	I	333	18.930	2.597	−32.921	1.00	16.47	C	C
  ATOM	9340	CB	CYS	I	333	19.646	3.216	−31.720	1.00	16.14	C	C
  ATOM	9341	SG	CYS	I	333	21.144	4.124	−32.136	1.00	17.09	C	S
  ATOM	9342	C	CYS	I	333	17.615	1.958	−32.475	1.00	15.73	C	C
  ATOM	9343	O	CYS	I	333	16.556	2.586	−32.511	1.00	15.43	C	O
  ATOM	9344	N	LEU	I	334	17.761	0.811	−31.819	1.00	15.06	C	N
  ATOM	9345	CA	LEU	I	334	16.643	−0.021	−31.394	1.00	13.79	C	C
  ATOM	9346	CB	LEU	I	334	16.607	−1.319	−32.203	1.00	13.39	C	C
  ATOM	9347	CG	LEU	I	334	16.482	−1.230	−33.725	1.00	13.93	C	C
  ATOM	9348	CD1	LEU	I	334	15.861	−2.496	−34.287	1.00	14.20	C	C
  ATOM	9349	CD2	LEU	I	334	15.686	−0.009	−34.151	1.00	14.52	C	C
  ATOM	9350	C	LEU	I	334	16.852	−0.366	−29.928	1.00	13.22	C	C
  ATOM	9351	O	LEU	I	334	17.968	−0.685	−29.520	1.00	13.31	C	O
  ATOM	9352	N	THR	I	335	15.768	−0.423	−29.167	1.00	12.58	C	N
  ATOM	9353	CA	THR	I	335	15.790	−1.126	−27.892	1.00	12.17	C	C
  ATOM	9354	CB	THR	I	335	15.955	−0.158	−26.706	1.00	12.02	C	C
  ATOM	9355	OG1	THR	I	335	16.652	1.018	−27.139	1.00	12.64	C	O
  ATOM	9356	CG2	THR	I	335	16.739	−0.825	−25.582	1.00	11.47	C	C
  ATOM	9357	C	THR	I	335	14.523	−1.942	−27.703	1.00	11.97	C	C
  ATOM	9358	O	THR	I	335	13.423	−1.471	−27.990	1.00	11.93	C	O
  ATOM	9359	N	ARG	I	336	14.700	−3.216	−27.379	1.00	11.60	C	N
  ATOM	9360	CA	ARG	I	336	13.573	−4.131	−27.260	1.00	12.15	C	C
  ATOM	9361	CB	ARG	I	336	14.066	−5.579	−27.235	1.00	12.16	C	C
  ATOM	9362	CG	ARG	I	336	13.124	−6.566	−27.906	1.00	12.67	C	C
  ATOM	9363	CD	ARG	I	336	13.876	−7.491	−28.846	1.00	12.52	C	C
  ATOM	9364	NE	ARG	I	336	14.414	−8.649	−28.144	1.00	12.35	C	N
  ATOM	9365	CZ	ARG	I	336	13.675	−9.665	−27.713	1.00	12.54	C	C
  ATOM	9366	NH1	ARG	I	336	12.384	−9.718	−28.013	1.00	12.38	C	N
  ATOM	9367	NH2	ARG	I	336	14.249	−10.681	−27.084	1.00	12.48	C	N
  ATOM	9368	C	ARG	I	336	12.761	−3.833	−26.004	1.00	12.71	C	C
  ATOM	9369	O	ARG	I	336	13.272	−3.932	−24.890	1.00	12.62	C	O
  ATOM	9370	N	THR	I	337	11.501	−3.457	−26.186	1.00	13.70	C	N
  ATOM	9371	CA	THR	I	337	10.696	−2.998	−25.065	1.00	14.91	C	C
  ATOM	9372	CB	THR	I	337	9.353	−2.405	−25.516	1.00	15.27	C	C
  ATOM	9373	OG1	THR	I	337	9.571	−1.474	−26.584	1.00	16.65	C	O
  ATOM	9374	CG2	THR	I	337	8.694	−1.678	−24.356	1.00	15.94	C	C
  ATOM	9375	C	THR	I	337	10.438	−4.115	−24.064	1.00	15.16	C	C
  ATOM	9376	O	THR	I	337	10.515	−3.902	−22.857	1.00	15.60	C	O
  ATOM	9377	N	ASP	I	338	10.036	−5.277	−24.566	1.00	15.15	C	N
  ATOM	9378	CA	ASP	I	338	9.394	−6.289	−23.732	1.00	15.52	C	C
  ATOM	9379	CB	ASP	I	338	8.653	−7.306	−24.602	1.00	16.81	C	C
  ATOM	9380	CG	ASP	I	338	9.242	−7.417	−26.000	1.00	20.57	C	C
  ATOM	9381	OD1	ASP	I	338	8.554	−7.950	−26.895	1.00	23.00	C	O
  ATOM	9382	OD2	ASP	I	338	10.395	−6.981	−26.200	1.00	22.92	C	O
  ATOM	9383	C	ASP	I	338	10.402	−7.004	−22.837	1.00	14.21	C	C
  ATOM	9384	O	ASP	I	338	10.930	−8.057	−23.196	1.00	14.00	C	O
  ATOM	9385	N	ARG	I	339	10.654	−6.432	−21.664	1.00	12.79	C	N
  ATOM	9386	CA	ARG	I	339	11.678	−6.949	−20.764	1.00	11.71	C	C
  ATOM	9387	CB	ARG	I	339	12.488	−5.810	−20.163	1.00	11.73	C	C
  ATOM	9388	CG	ARG	I	339	13.374	−5.080	−21.129	1.00	12.49	C	C
  ATOM	9389	CD	ARG	I	339	14.312	−4.211	−20.346	1.00	13.24	C	C
  ATOM	9390	NE	ARG	I	339	14.580	−2.944	−21.005	1.00	12.04	C	N
  ATOM	9391	CZ	ARG	I	339	15.717	−2.282	−20.858	1.00	11.74	C	C
  ATOM	9392	NH1	ARG	I	339	16.664	−2.771	−20.072	1.00	13.43	C	N
  ATOM	9393	NH2	ARG	I	339	15.904	−1.125	−21.475	1.00	9.80	C	N
  ATOM	9394	C	ARG	I	339	11.062	−7.727	−19.622	1.00	11.16	C	C
  ATOM	9395	O	ARG	I	339	10.029	−7.326	−19.087	1.00	11.37	C	O
  ATOM	9396	N	GLY	I	340	11.892	−8.572	−19.027	1.00	10.43	C	N
  ATOM	9397	CA	GLY	I	340	11.574	−9.178	−17.749	1.00	9.52	C	C
  ATOM	9398	C	GLY	I	340	11.463	−10.678	−17.876	1.00	8.80	C	C
  ATOM	9399	O	GLY	I	340	12.269	−11.313	−18.555	1.00	8.56	C	O
  ATOM	9400	N	TRP	I	341	10.532	−11.257	−17.129	1.00	8.25	C	N
  ATOM	9401	CA	TRP	I	341	10.462	−12.699	−17.005	1.00	7.98	C	C
  ATOM	9402	CB	TRP	I	341	10.018	−13.097	−15.605	1.00	7.79	C	C
  ATOM	9403	CG	TRP	I	341	11.120	−13.020	−14.622	1.00	7.67	C	C
  ATOM	9404	CD1	TRP	I	341	11.382	−11.986	−13.775	1.00	8.12	C	C
  ATOM	9405	NE1	TRP	I	341	12.511	−12.252	−13.042	1.00	8.60	C	N
  ATOM	9406	CE2	TRP	I	341	13.037	−13.447	−13.459	1.00	7.57	C	C
  ATOM	9407	CD2	TRP	I	341	12.217	−13.931	−14.495	1.00	7.52	C	C
  ATOM	9408	CE3	TRP	I	341	12.541	−15.150	−15.098	1.00	7.86	C	C
  ATOM	9409	CZ3	TRP	I	341	13.653	−15.837	−14.650	1.00	7.14	C	C
  ATOM	9410	CH2	TRP	I	341	14.457	−15.323	−13.625	1.00	6.39	C	C
  ATOM	9411	CZ2	TRP	I	341	14.164	−14.134	−13.017	1.00	7.30	C	C
  ATOM	9412	C	TRP	I	341	9.525	−13.288	−18.037	1.00	8.26	C	C
  ATOM	9413	O	TRP	I	341	8.322	−13.022	−18.031	1.00	8.35	C	O
  ATOM	9414	N	TYR	I	342	10.085	−14.100	−18.922	1.00	8.44	C	N
  ATOM	9415	CA	TYR	I	342	9.308	−15.102	−19.616	1.00	8.53	C	C
  ATOM	9416	CB	TYR	I	342	9.755	−15.202	−21.069	1.00	8.43	C	C
  ATOM	9417	CG	TYR	I	342	9.687	−13.885	−21.793	1.00	9.17	C	C
  ATOM	9418	CD1	TYR	I	342	10.592	−12.874	−21.499	1.00	10.32	C	C
  ATOM	9419	CE1	TYR	I	342	10.474	−11.625	−22.068	1.00	10.99	C	C
  ATOM	9420	CZ	TYR	I	342	9.395	−11.349	−22.873	1.00	11.00	C	C
  ATOM	9421	OH	TYR	I	342	9.267	−10.102	−23.435	1.00	12.82	C	O
  ATOM	9422	CE2	TYR	I	342	8.433	−12.307	−23.105	1.00	10.67	C	C
  ATOM	9423	CD2	TYR	I	342	8.569	−13.555	−22.542	1.00	10.41	C	C
  ATOM	9424	C	TYR	I	342	9.469	−16.437	−18.925	1.00	8.64	C	C
  ATOM	9425	O	TYR	I	342	10.376	−16.628	−18.115	1.00	8.40	C	O
  ATOM	9426	N	CYS	I	343	8.558	−17.351	−19.224	1.00	8.87	C	N
  ATOM	9427	CA	CYS	I	343	8.370	−18.516	−18.389	1.00	9.35	C	C
  ATOM	9428	CB	CYS	I	343	8.266	−18.116	−16.915	1.00	9.17	C	C
  ATOM	9429	SG	CYS	I	343	8.138	−19.512	−15.769	1.00	11.88	C	S
  ATOM	9430	C	CYS	I	343	7.151	−19.312	−18.831	1.00	9.42	C	C
  ATOM	9431	O	CYS	I	343	6.039	−18.788	−18.900	1.00	9.96	C	O
  ATOM	9432	N	ASP	I	344	7.408	−20.545	−19.254	1.00	9.36	C	N
  ATOM	9433	CA	ASP	I	344	6.483	−21.302	−20.083	1.00	9.24	C	C
  ATOM	9434	CB	ASP	I	344	7.122	−22.628	−20.500	1.00	9.34	C	C
  ATOM	9435	CG	ASP	I	344	7.796	−22.551	−21.856	1.00	10.72	C	C
  ATOM	9436	OD1	ASP	I	344	7.123	−22.161	−22.833	1.00	13.93	C	O
  ATOM	9437	OD2	ASP	I	344	9.003	−22.864	−21.942	1.00	11.87	C	O
  ATOM	9438	C	ASP	I	344	5.198	−21.576	−19.320	1.00	9.09	C	C
  ATOM	9439	O	ASP	I	344	5.233	−22.061	−18.192	1.00	9.39	C	O
  ATOM	9440	N	ASN	I	345	4.067	−21.385	−19.988	1.00	9.13	C	N
  ATOM	9441	CA	ASN	I	345	2.801	−21.924	−19.510	1.00	9.52	C	C
  ATOM	9442	CB	ASN	I	345	1.770	−20.804	−19.361	1.00	9.61	C	C
  ATOM	9443	CG	ASN	I	345	0.742	−21.101	−18.293	1.00	9.21	C	C
  ATOM	9444	OD1	ASN	I	345	1.075	−21.251	−17.118	1.00	6.21	C	O
  ATOM	9445	ND2	ASN	I	345	−0.511	−21.247	−18.706	1.00	11.05	C	N
  ATOM	9446	C	ASN	I	345	2.271	−23.022	−20.427	1.00	10.06	C	C
  ATOM	9447	O	ASN	I	345	3.005	−23.546	−21.267	1.00	11.10	C	O
  ATOM	9448	N	ALA	I	346	1.017	−23.411	−20.223	1.00	9.74	C	N
  ATOM	9449	CA	ALA	I	346	0.416	−24.492	−20.998	1.00	9.58	C	C
  ATOM	9450	CB	ALA	I	346	−1.062	−24.635	−20.650	1.00	9.60	C	C
  ATOM	9451	C	ALA	I	346	0.593	−24.278	−22.502	1.00	9.66	C	C
  ATOM	9452	O	ALA	I	346	−0.241	−23.639	−23.145	1.00	9.39	C	O
  ATOM	9453	N	GLY	I	347	1.655	−24.849	−23.065	1.00	10.04	C	N
  ATOM	9454	CA	GLY	I	347	1.836	−24.857	−24.513	1.00	10.68	C	C
  ATOM	9455	C	GLY	I	347	1.879	−23.454	−25.085	1.00	10.90	C	C
  ATOM	9456	O	GLY	I	347	1.661	−23.251	−26.280	1.00	11.46	C	O
  ATOM	9457	N	SER	I	348	2.016	−22.477	−24.193	1.00	10.30	C	N
  ATOM	9458	CA	SER	I	348	2.256	−21.088	−24.567	1.00	9.94	C	C
  ATOM	9459	CB	SER	I	348	0.933	−20.322	−24.613	1.00	9.88	C	C
  ATOM	9460	OG	SER	I	348	0.000	−20.969	−25.461	1.00	10.09	C	O
  ATOM	9461	C	SER	I	348	3.194	−20.462	−23.538	1.00	9.60	C	C
  ATOM	9462	O	SER	I	348	3.700	−21.157	−22.660	1.00	9.59	C	O
  ATOM	9463	N	VAL	I	349	3.494	−19.178	−23.689	1.00	9.54	C	N
  ATOM	9464	CA	VAL	I	349	4.452	−18.532	−22.800	1.00	9.56	C	C
  ATOM	9465	CB	VAL	I	349	5.700	−18.047	−23.558	1.00	9.28	C	C
  ATOM	9466	CG1	VAL	I	349	6.722	−17.476	−22.589	1.00	9.24	C	C
  ATOM	9467	CG2	VAL	I	349	6.303	−19.183	−24.370	1.00	9.94	C	C
  ATOM	9468	C	VAL	I	349	3.832	−17.367	−22.041	1.00	9.59	C	C
  ATOM	9469	O	VAL	I	349	3.179	−16.506	−22.631	1.00	9.69	C	O
  ATOM	9470	N	SER	I	350	4.073	−17.326	−20.735	1.00	9.93	C	N
  ATOM	9471	CA	SER	I	350	3.559	−16.252	−19.896	1.00	10.44	C	C
  ATOM	9472	CB	SER	I	350	2.926	−16.815	−18.620	1.00	10.04	C	C
  ATOM	9473	OG	SER	I	350	1.578	−17.196	−18.841	1.00	8.41	C	O
  ATOM	9474	C	SER	I	350	4.629	−15.218	−19.557	1.00	11.45	C	C
  ATOM	9475	O	SER	I	350	5.746	−15.561	−19.168	1.00	11.58	C	O
  ATOM	9476	N	PHE	I	351	4.259	−13.948	−19.679	1.00	12.28	C	N
  ATOM	9477	CA	PHE	I	351	5.200	−12.847	−19.543	1.00	13.04	C	C
  ATOM	9478	CB	PHE	I	351	5.320	−12.089	−20.867	1.00	12.87	C	C
  ATOM	9479	CG	PHE	I	351	6.094	−10.809	−20.763	1.00	13.52	C	C
  ATOM	9480	CD1	PHE	I	351	7.344	−10.788	−20.172	1.00	13.76	C	C
  ATOM	9481	CE1	PHE	I	351	8.066	−9.613	−20.085	1.00	14.10	C	C
  ATOM	9482	CZ	PHE	I	351	7.541	−8.442	−20.588	1.00	14.07	C	C
  ATOM	9483	CE2	PHE	I	351	6.305	−8.452	−21.197	1.00	14.14	C	C
  ATOM	9484	CD2	PHE	I	351	5.580	−9.629	−21.270	1.00	13.92	C	C
  ATOM	9485	C	PHE	I	351	4.742	−11.899	−18.441	1.00	13.84	C	C
  ATOM	9486	O	PHE	I	351	3.579	−11.499	−18.394	1.00	13.96	C	O
  ATOM	9487	N	PHE	I	352	5.655	−11.574	−17.534	1.00	14.72	C	N
  ATOM	9488	CA	PHE	I	352	5.344	−10.699	−16.412	1.00	15.98	C	C
  ATOM	9489	CB	PHE	I	352	5.570	−11.435	−15.093	1.00	15.75	C	C
  ATOM	9490	CG	PHE	I	352	5.295	−12.909	−15.169	1.00	15.51	C	C
  ATOM	9491	CD1	PHE	I	352	6.188	−13.762	−15.803	1.00	15.05	C	C
  ATOM	9492	CE1	PHE	I	352	5.926	−15.116	−15.902	1.00	14.05	C	C
  ATOM	9493	CZ	PHE	I	352	4.745	−15.624	−15.402	1.00	13.28	C	C
  ATOM	9494	CE2	PHE	I	352	3.833	−14.777	−14.796	1.00	13.71	C	C
  ATOM	9495	CD2	PHE	I	352	4.099	−13.425	−14.704	1.00	14.94	C	C
  ATOM	9496	C	PHE	I	352	6.195	−9.438	−16.453	1.00	17.56	C	C
  ATOM	9497	O	PHE	I	352	7.419	−9.509	−16.360	1.00	17.74	C	O
  ATOM	9498	N	PRO	I	353	5.541	−8.271	−16.525	1.00	19.05	C	N
  ATOM	9499	CA	PRO	I	353	6.188	−7.074	−17.055	1.00	20.40	C	C
  ATOM	9500	CB	PRO	I	353	5.010	−6.146	−17.365	1.00	20.26	C	C
  ATOM	9501	CG	PRO	I	353	3.839	−7.052	−17.522	1.00	19.71	C	C
  ATOM	9502	CD	PRO	I	353	4.073	−8.155	−16.545	1.00	18.97	C	C
  ATOM	9503	C	PRO	I	353	7.136	−6.408	−16.058	1.00	21.94	C	C
  ATOM	9504	O	PRO	I	353	8.087	−5.745	−16.470	1.00	22.29	C	O
  ATOM	9505	N	GLN	I	354	6.858	−6.544	−14.763	1.00	23.38	C	N
  ATOM	9506	CA	GLN	I	354	7.646	−5.847	−13.743	1.00	24.64	C	C
  ATOM	9507	CB	GLN	I	354	6.943	−4.569	−13.274	1.00	24.93	C	C
  ATOM	9508	CG	GLN	I	354	5.458	−4.509	−13.587	1.00	26.00	C	C
  ATOM	9509	CD	GLN	I	354	4.646	−5.481	−12.756	1.00	25.92	C	C
  ATOM	9510	OE1	GLN	I	354	4.710	−5.474	−11.527	1.00	25.67	C	O
  ATOM	9511	NE2	GLN	I	354	3.870	−6.324	−13.427	1.00	24.27	C	N
  ATOM	9512	C	GLN	I	354	8.048	−6.707	−12.543	1.00	24.85	C	C
  ATOM	9513	O	GLN	I	354	7.280	−7.556	−12.088	1.00	24.51	C	O
  ATOM	9514	N	ALA	I	355	9.200	−6.384	−11.959	1.00	25.22	C	N
  ATOM	9515	CA	ALA	I	355	9.818	−7.215	−10.926	1.00	25.34	C	C
  ATOM	9516	CB	ALA	I	355	10.949	−6.458	−10.245	1.00	25.09	C	C
  ATOM	9517	C	ALA	I	355	8.809	−7.711	−9.892	1.00	24.92	C	C
  ATOM	9518	O	ALA	I	355	8.679	−8.915	−9.669	1.00	25.23	C	O
  ATOM	9519	N	GLU	I	356	8.278	−6.771	−9.115	1.00	23.93	C	N
  ATOM	9520	CA	GLU	I	356	7.089	−6.998	−8.295	1.00	22.77	C	C
  ATOM	9521	CB	GLU	I	356	5.993	−5.995	−8.658	1.00	23.22	C	C
  ATOM	9522	CG	GLU	I	356	6.412	−4.545	−8.500	1.00	26.33	C	C
  ATOM	9523	CD	GLU	I	356	7.250	−4.314	−7.258	1.00	30.93	C	C
  ATOM	9524	OE1	GLU	I	356	8.490	−4.231	−7.380	1.00	31.97	C	O
  ATOM	9525	OE2	GLU	I	356	6.668	−4.227	−6.156	1.00	32.21	C	O
  ATOM	9526	C	GLU	I	356	6.547	−8.419	−8.377	1.00	21.31	C	C
  ATOM	9527	O	GLU	I	356	6.338	−9.070	−7.354	1.00	21.01	C	O
  ATOM	9528	N	THR	I	357	6.137	−8.809	−9.577	1.00	19.51	C	N
  ATOM	9529	CA	THR	I	357	5.358	−10.023	−9.766	1.00	17.55	C	C
  ATOM	9530	CB	THR	I	357	4.829	−10.115	−11.207	1.00	17.30	C	C
  ATOM	9531	OG1	THR	I	357	5.071	−8.873	−11.882	1.00	17.32	C	O
  ATOM	9532	CG2	THR	I	357	3.335	−10.387	−11.203	1.00	17.72	C	C
  ATOM	9533	C	THR	I	357	6.178	−11.268	−9.433	1.00	16.62	C	C
  ATOM	9534	O	THR	I	357	5.631	−12.286	−9.008	1.00	17.29	C	O
  ATOM	9535	N	CYS	I	358	7.498	−11.146	−9.526	1.00	14.88	C	N
  ATOM	9536	CA	CYS	I	358	8.365	−12.317	−9.566	1.00	13.15	C	C
  ATOM	9537	CB	CYS	I	358	8.955	−12.501	−10.961	1.00	13.04	C	C
  ATOM	9538	SG	CYS	I	358	7.735	−12.899	−12.228	1.00	14.02	C	S
  ATOM	9539	C	CYS	I	358	9.478	−12.255	−8.529	1.00	12.08	C	C
  ATOM	9540	O	CYS	I	358	10.186	−11.252	−8.417	1.00	12.15	C	O
  ATOM	9541	N	LYS	I	359	9.640	−13.345	−7.788	1.00	11.35	C	N
  ATOM	9542	CA	LYS	I	359	10.793	−13.519	−6.918	1.00	11.01	C	C
  ATOM	9543	CB	LYS	I	359	10.349	−13.675	−5.460	1.00	11.16	C	C
  ATOM	9544	CG	LYS	I	359	8.858	−13.470	−5.229	1.00	13.28	C	C
  ATOM	9545	CD	LYS	I	359	8.607	−12.427	−4.150	1.00	16.11	C	C
  ATOM	9546	CE	LYS	I	359	7.124	−12.287	−3.850	1.00	17.91	C	C
  ATOM	9547	NZ	LYS	I	359	6.818	−11.012	−3.145	1.00	20.99	C	N
  ATOM	9548	C	LYS	I	359	11.592	−14.739	−7.349	1.00	10.46	C	C
  ATOM	9549	O	LYS	I	359	11.091	−15.589	−8.085	1.00	10.70	C	O
  ATOM	9550	N	VAL	I	360	12.791	−14.880	−6.798	1.00	9.99	C	N
  ATOM	9551	CA	VAL	I	360	13.720	−15.885	−7.282	1.00	9.84	C	C
  ATOM	9552	CB	VAL	I	360	14.452	−15.412	−8.541	1.00	9.42	C	C
  ATOM	9553	CG1	VAL	I	360	15.135	−14.066	−8.288	1.00	10.07	C	C
  ATOM	9554	CG2	VAL	I		360	15.454	−16.473	−8.996	1.00	9.56	C	C
  ATOM	9555	C	VAL	I	360	14.738	−16.297	−6.229	1.00	9.98	C	C
  ATOM	9556	O	VAL	I	360	15.380	−15.457	−5.598	1.00	9.96	C	O
  ATOM	9557	N	GLN	I	361	14.900	−17.604	−6.071	1.00	10.39	C	N
  ATOM	9558	CA	GLN	I	361	15.781	−18.150	−5.052	1.00	11.53	C	C
  ATOM	9559	CB	GLN	I	361	14.966	−18.692	−3.880	1.00	12.03	C	C
  ATOM	9560	CG	GLN	I	361	15.810	−19.254	−2.750	1.00	16.44	C	C
  ATOM	9561	CD	GLN	I	361	15.388	−18.722	−1.398	1.00	25.16	C	C
  ATOM	9562	OE1	GLN	I	361	14.773	−19.434	−0.604	1.00	29.01	C	O
  ATOM	9563	NE2	GLN	I	361	15.686	−17.453	−1.141	1.00	27.20	C	N
  ATOM	9564	C	GLN	I	361	16.613	−19.271	−5.641	1.00	11.15	C	C
  ATOM	9565	O	GLN	I	361	16.114	−20.375	−5.854	1.00	11.80	C	O
  ATOM	9566	N	SER	I	362	17.877	−18.986	−5.925	1.00	10.90	C	N
  ATOM	9567	CA	SER	I	362	18.671	−19.921	−6.695	1.00	10.30	C	C
  ATOM	9568	CB	SER	I	362	18.610	−21.302	−6.040	1.00	10.47	C	C
  ATOM	9569	OG	SER	I	362	19.659	−22.138	−6.491	1.00	11.17	C	O
  ATOM	9570	C	SER	I	362	18.088	−19.980	−8.103	1.00	9.58	C	C
  ATOM	9571	O	SER	I	362	17.759	−18.946	−8.683	1.00	9.48	C	O
  ATOM	9572	N	ASN	I	363	17.806	−21.188	−8.577	1.00	9.12	C	N
  ATOM	9573	CA	ASN	I	363	17.229	−21.365	−9.904	1.00	8.73	C	C
  ATOM	9574	CB	ASN	I	363	17.821	−22.602	−10.568	1.00	9.01	C	C
  ATOM	9575	CG	ASN	I	363	17.547	−23.864	−9.781	1.00	9.29	C	C
  ATOM	9576	OD1	ASN	I	363	16.903	−23.826	−8.732	1.00	9.82	C	O
  ATOM	9577	ND2	ASN	I	363	17.981	−25.000	−10.314	1.00	10.08	C	N
  ATOM	9578	C	ASN	I	363	15.716	−21.503	−9.827	1.00	8.12	C	C
  ATOM	9579	O	ASN	I	363	15.084	−22.042	−10.736	1.00	8.10	C	O
  ATOM	9580	N	ARG	I	364	15.168	−21.165	−8.665	1.00	7.20	C	N
  ATOM	9581	CA	ARG	I	364	13.731	−21.222	−8.445	1.00	6.82	C	C
  ATOM	9582	CB	ARG	I	364	13.427	−21.658	−7.012	1.00	6.91	C	C
  ATOM	9583	CG	ARG	I	364	12.287	−22.649	−6.908	1.00	7.92	C	C
  ATOM	9584	CD	ARG	I	364	12.520	−23.817	−7.843	1.00	8.20	C	C
  ATOM	9585	NE	ARG	I	364	11.374	−24.061	−8.711	1.00	8.70	C	N
  ATOM	9586	CZ	ARG	I	364	11.056	−25.255	−9.196	1.00	8.88	C	C
  ATOM	9587	NH1	ARG	I	364	11.800	−26.309	−8.894	1.00	8.57	C	N
  ATOM	9588	NH2	ARG	I	364	9.976	−25.403	−9.950	1.00	10.59	C	N
  ATOM	9589	C	ARG	I	364	13.110	−19.861	−8.694	1.00	6.58	C	C
  ATOM	9590	O	ARG	I	364	13.540	−18.861	−8.121	1.00	6.65	C	O
  ATOM	9591	N	VAL	I	365	12.031	−19.846	−9.466	1.00	6.64	C	N
  ATOM	9592	CA	VAL	I	365	11.325	−18.609	−9.756	1.00	6.54	C	C
  ATOM	9593	CB	VAL	I	365	11.399	−18.261	−11.254	1.00	5.95	C	C
  ATOM	9594	CG1	VAL	I	365	10.374	−17.196	−11.608	1.00	5.48	C	C
  ATOM	9595	CG2	VAL	I	365	12.801	−17.804	−11.623	1.00	6.22	C	C
  ATOM	9596	C	VAL	I	365	9.866	−18.723	−9.335	1.00	7.35	C	C
  ATOM	9597	O	VAL	I	365	9.271	−19.799	−9.416	1.00	8.33	C	O
  ATOM	9598	N	PHE	I	366	9.309	−17.619	−8.843	1.00	7.37	C	N
  ATOM	9599	CA	PHE	I	366	7.919	−17.584	−8.401	1.00	7.44	C	C
  ATOM	9600	CB	PHE	I	366	7.840	−17.604	−6.875	1.00	7.30	C	C
  ATOM	9601	CG	PHE	I	366	8.426	−18.834	−6.255	1.00	6.70	C	C
  ATOM	9602	CD1	PHE	I	366	9.799	−18.991	−6.163	1.00	6.70	C	C
  ATOM	9603	CE1	PHE	I	366	10.345	−20.120	−5.588	1.00	5.94	C	C
  ATOM	9604	CZ	PHE	I	366	9.520	−21.083	−5.055	1.00	5.71	C	C
  ATOM	9605	CE2	PHE	I	366	8.149	−20.934	−5.130	1.00	5.96	C	C
  ATOM	9606	CD2	PHE	I	366	7.609	−19.805	−5.710	1.00	6.52	C	C
  ATOM	9607	C	PHE	I	366	7.236	−16.335	−8.919	1.00	7.45	C	C
  ATOM	9608	O	PHE	I	366	7.530	−15.225	−8.476	1.00	7.45	C	O
  ATOM	9609	N	CYS	I	367	6.282	−16.524	−9.819	1.00	8.00	C	N
  ATOM	9610	CA	CYS	I	367	5.626	−15.400	−10.450	1.00	8.90	C	C
  ATOM	9611	CB	CYS	I	367	5.985	−15.338	−11.934	1.00	9.46	C	C
  ATOM	9612	SG	CYS	I	367	7.712	−14.929	−12.259	1.00	10.79	C	S
  ATOM	9613	C	CYS	I	367	4.121	−15.484	−10.268	1.00	9.09	C	C
  ATOM	9614	O	CYS	I	367	3.591	−16.493	−9.799	1.00	9.24	C	O
  ATOM	9615	N	ASP	I	368	3.449	−14.382	−10.568	1.00	9.54	C	N
  ATOM	9616	CA	ASP	I	368	2.034	−14.255	−10.285	1.00	10.55	C	C
  ATOM	9617	CB	ASP	I	368	1.792	−13.067	−9.349	1.00	10.53	C	C
  ATOM	9618	CG	ASP	I	368	0.421	−13.102	−8.698	1.00	11.11	C	C
  ATOM	9619	OD1	ASP	I	368	−0.574	−13.335	−9.415	1.00	11.42	C	O
  ATOM	9620	OD2	ASP	I	368	0.323	−12.765	−7.499	1.00	11.35	C	O
  ATOM	9621	C	ASP	I	368	1.266	−14.073	−11.590	1.00	11.45	C	C
  ATOM	9622	O	ASP	I	368	1.418	−13.061	−12.274	1.00	12.05	C	O
  ATOM	9623	N	THR	I	369	0.563	−15.122	−12.003	1.00	12.41	C	N
  ATOM	9624	CA	THR	I	369	−0.399	−15.013	−13.089	1.00	13.00	C	C
  ATOM	9625	CB	THR	I	369	−1.513	−16.063	−12.953	1.00	12.69	C	C
  ATOM	9626	OG1	THR	I	369	−0.935	−17.374	−12.929	1.00	11.72	C	O
  ATOM	9627	CG2	THR	I	369	−2.488	−15.962	−14.115	1.00	13.33	C	C
  ATOM	9628	C	THR	I	369	−1.034	−13.632	−13.093	1.00	14.13	C	C
  ATOM	9629	O	THR	I	369	−0.895	−12.874	−14.051	1.00	14.72	C	O
  ATOM	9630	N	MET	I	370	−1.675	−13.289	−11.984	1.00	15.25	C	N
  ATOM	9631	CA	MET	I	370	−2.681	−12.240	−11.975	1.00	16.60	C	C
  ATOM	9632	CB	MET	I	370	−2.538	−11.361	−10.734	1.00	17.42	C	C
  ATOM	9633	CG	MET	I		370	−3.744	−11.411	−9.811	1.00	20.31	C	C
  ATOM	9634	SD	MET	I		370	−5.284	−10.974	−10.642	1.00	26.43	C	S
  ATOM	9635	CE	MET	I		370	−5.320	−12.185	−11.963	1.00	24.07	C	C
  ATOM	9636	C	MET	I	370	−2.700	−11.396	−13.249	1.00	16.54	C	C
  ATOM	9637	O	MET	I		370	−3.707	−11.367	−13.953	1.00	16.74	C	O
  ATOM	9638	N	ASN	I	371	−1.610	−10.691	−13.540	1.00	16.35	C	N
  ATOM	9639	CA	ASN	I	371	−1.614	−9.772	−14.680	1.00	16.07	C	C
  ATOM	9640	CB	ASN	I	371	−1.375	−8.326	−14.232	1.00	16.41	C	C
  ATOM	9641	CG	ASN	I	371	−2.619	−7.690	−13.634	1.00	16.71	C	C
  ATOM	9642	OD1	ASN	I	371	−3.501	−7.228	−14.356	1.00	15.75	C	O
  ATOM	9643	ND2	ASN	I	371	−2.722	−7.724	−12.310	1.00	17.76	C	N
  ATOM	9644	C	ASN	I	371	−0.698	−10.167	−15.842	1.00	15.55	C	C
  ATOM	9645	O	ASN	I	371	−0.650	−9.478	−16.862	1.00	15.84	C	O
  ATOM	9646	N	SER	I	372	−0.166	−11.383	−15.771	1.00	14.76	C	N
  ATOM	9647	CA	SER	I	372	0.540	−11.990	−16.894	1.00	13.91	C	C
  ATOM	9648	CB	SER	I	372	0.561	−13.512	−16.746	1.00	14.04	C	C
  ATOM	9649	OG	SER	I	372	−0.696	−14.071	−17.084	1.00	15.09	C	O
  ATOM	9650	C	SER	I	372	−0.071	−11.614	−18.242	1.00	13.07	C	C
  ATOM	9651	O	SER	I	372	−1.291	−11.511	−18.373	1.00	13.02	C	O
  ATOM	9652	N	LEU	I	373	0.781	−11.525	−19.263	1.00	12.23	C	N
  ATOM	9653	CA	LEU	I	373	0.352	−11.621	−20.658	1.00	11.45	C	C
  ATOM	9654	CB	LEU	I	373	0.999	−10.504	−21.485	1.00	11.43	C	C
  ATOM	9655	CG	LEU	I	373	0.250	−9.176	−21.636	1.00	11.04	C	C
  ATOM	9656	CD1	LEU	I	373	−0.580	−8.867	−20.406	1.00	11.76	C	C
  ATOM	9657	CD2	LEU	I	373	1.213	−8.035	−21.928	1.00	10.49	C	C
  ATOM	9658	C	LEU	I	373	0.727	−12.982	−21.247	1.00	11.17	C	C
  ATOM	9659	O	LEU	I	373	1.819	−13.492	−21.000	1.00	11.27	C	O
  ATOM	9660	N	THR	I	374	−0.164	−13.546	−22.056	1.00	10.70	C	N
  ATOM	9661	CA	THR	I	374	0.062	−14.869	−22.633	1.00	10.23	C	C
  ATOM	9662	CB	THR	I	374	−1.187	−15.768	−22.531	1.00	10.24	C	C
  ATOM	9663	OG1	THR	I	374	−1.999	−15.346	−21.429	1.00	11.25	C	O
  ATOM	9664	CG2	THR	I	374	−0.785	−17.224	−22.338	1.00	10.52	C	C
  ATOM	9665	C	THR	I	374	0.481	−14.772	−24.091	1.00	9.54	C	C
  ATOM	9666	O	THR	I	374	−0.164	−14.097	−24.893	1.00	9.70	C	O
  ATOM	9667	N	LEU	I	375	1.576	−15.444	−24.422	1.00	8.83	C	N
  ATOM	9668	CA	LEU	I	375	2.236	−15.253	−25.704	1.00	7.83	C	C
  ATOM	9669	CB	LEU	I	375	3.470	−14.361	−25.547	1.00	7.38	C	C
  ATOM	9670	CG	LEU	I	375	3.309	−13.047	−24.780	1.00	5.06	C	C
  ATOM	9671	CD1	LEU	I	375	4.669	−12.411	−24.533	1.00	2.41	C	C
  ATOM	9672	CD2	LEU	I	375	2.397	−12.098	−25.535	1.00	4.31	C	C
  ATOM	9673	C	LEU	I	375	2.644	−16.600	−26.283	1.00	7.79	C	C
  ATOM	9674	O	LEU	I	375	2.703	−17.598	−25.565	1.00	7.92	C	O
  ATOM	9675	N	PRO	I	376	2.914	−16.629	−27.595	1.00	7.51	C	N
  ATOM	9676	CA	PRO	I	376	3.325	−17.826	−28.323	1.00	7.90	C	C
  ATOM	9677	CB	PRO	I	376	2.852	−17.538	−29.748	1.00	7.90	C	C
  ATOM	9678	CG	PRO	I	376	2.913	−16.062	−29.858	1.00	7.97	C	C
  ATOM	9679	CD	PRO	I	376	2.537	−15.534	−28.505	1.00	7.40	C	C
  ATOM	9680	C	PRO	I	376	4.838	−18.023	−28.310	1.00	8.35	C	C
  ATOM	9681	O	PRO	I	376	5.589	−17.062	−28.484	1.00	8.71	C	O
  ATOM	9682	N	SER	I	377	5.263	−19.283	−28.263	1.00	9.11	C	N
  ATOM	9683	CA	SER	I	377	6.682	−19.622	−28.207	1.00	9.91	C	C
  ATOM	9684	CB	SER	I	377	6.880	−21.137	−28.330	1.00	10.23	C	C
  ATOM	9685	OG	SER	I	377	5.713	−21.842	−27.939	1.00	10.90	C	O
  ATOM	9686	C	SER	I	377	7.438	−18.911	−29.319	1.00	10.14	C	C
  ATOM	9687	O	SER	I	377	8.660	−19.024	−29.425	1.00	10.08	C	O
  ATOM	9688	N	GLU	I	378	6.683	−18.286	−30.215	1.00	10.71	C	N
  ATOM	9689	CA	GLU	I	378	7.256	−17.563	−31.339	1.00	11.40	C	C
  ATOM	9690	CB	GLU	I	378	6.177	−17.256	−32.379	1.00	11.65	C	C
  ATOM	9691	CG	GLU	I	378	5.858	−18.418	−33.312	1.00	13.46	C	C
  ATOM	9692	CD	GLU	I	378	5.249	−19.608	−32.588	1.00	16.20	C	C
  ATOM	9693	OE1	GLU	I	378	4.999	−19.505	−31.368	1.00	15.73	C	O
  ATOM	9694	OE2	GLU	I	378	4.989	−20.636	−33.250	1.00	18.38	C	O
  ATOM	9695	C	GLU	I	378	7.922	−16.274	−30.873	1.00	11.27	C	C
  ATOM	9696	O	GLU	I	378	8.776	−15.722	−31.567	1.00	11.28	C	O
  ATOM	9697	N	VAL	I	379	7.570	−15.827	−29.672	1.00	11.31	C	N
  ATOM	9698	CA	VAL	I	379	8.268	−14.708	−29.056	1.00	11.59	C	C
  ATOM	9699	CB	VAL	I	379	7.849	−14.504	−27.591	1.00	11.27	C	C
  ATOM	9700	CG1	VAL	I	379	8.894	−13.674	−26.858	1.00	11.60	C	C
  ATOM	9701	CG2	VAL	I	379	6.486	−13.833	−27.520	1.00	11.54	C	C
  ATOM	9702	C	VAL	I	379	9.779	−14.907	−29.124	1.00	12.16	C	C
  ATOM	9703	O	VAL	I	379	10.533	−13.943	−29.255	1.00	12.51	C	O
  ATOM	9704	N	ASN	I	380	10.219	−16.158	−29.030	1.00	12.98	C	N
  ATOM	9705	CA	ASN	I	380	11.637	−16.453	−28.854	1.00	14.00	C	C
  ATOM	9706	CB	ASN	I	380	11.854	−17.947	−28.579	1.00	14.59	C	C
  ATOM	9707	CG	ASN	I	380	11.318	−18.381	−27.224	1.00	17.09	C	C
  ATOM	9708	OD1	ASN	I	380	12.070	−18.488	−26.256	1.00	20.41	C	O
  ATOM	9709	ND2	ASN	I	380	10.045	−18.763	−27.186	1.00	18.86	C	N
  ATOM	9710	C	ASN	I	380	12.477	−16.006	−30.051	1.00	13.96	C	C
  ATOM	9711	O	ASN	I	380	13.619	−15.576	−29.890	1.00	14.38	C	O
  ATOM	9712	N	LEU	I	381	11.925	−16.159	−31.252	1.00	13.61	C	N
  ATOM	9713	CA	LEU	I	381	12.638	−15.798	−32.475	1.00	13.72	C	C
  ATOM	9714	CB	LEU	I	381	11.742	−15.996	−33.698	1.00	13.79	C	C
  ATOM	9715	CG	LEU	I	381	10.720	−17.130	−33.607	1.00	14.92	C	C
  ATOM	9716	CD1	LEU	I	381	9.817	−17.138	−34.830	1.00	15.56	C	C
  ATOM	9717	CD2	LEU	I	381	11.421	−18.470	−33.446	1.00	15.78	C	C
  ATOM	9718	C	LEU	I	381	13.093	−14.349	−32.401	1.00	13.62	C	C
  ATOM	9719	O	LEU	I	381	14.017	−13.934	−33.100	1.00	13.57	C	O
  ATOM	9720	N	CYS	I	382	12.473	−13.607	−31.494	1.00	13.47	C	N
  ATOM	9721	CA	CYS	I	382	12.727	−12.187	−31.357	1.00	13.57	C	C
  ATOM	9722	CB	CYS	I	382	11.613	−11.538	−30.545	1.00	13.62	C	C
  ATOM	9723	SG	CYS	I	382	10.346	−10.770	−31.551	1.00	15.64	C	S
  ATOM	9724	C	CYS	I	382	14.073	−11.928	−30.696	1.00	13.33	C	C
  ATOM	9725	O	CYS	I	382	14.690	−10.887	−30.923	1.00	13.57	C	O
  ATOM	9726	N	ASN	I	383	14.565	−12.914	−29.948	1.00	13.21	C	N
  ATOM	9727	CA	ASN	I	383	15.925	−12.865	−29.415	1.00	13.22	C	C
  ATOM	9728	CB	ASN	I	383	16.191	−14.054	−28.491	1.00	13.18	C	C
  ATOM	9729	CG	ASN	I	383	15.154	−14.186	−27.400	1.00	13.42	C	C
  ATOM	9730	OD1	ASN	I	383	14.774	−13.202	−26.769	1.00	13.68	C	O
  ATOM	9731	ND2	ASN	I	383	14.660	−15.402	−27.199	1.00	14.32	C	N
  ATOM	9732	C	ASN	I	383	16.959	−12.845	−30.530	1.00	13.28	C	C
  ATOM	9733	O	ASN	I	383	18.081	−12.374	−30.344	1.00	13.50	C	O
  ATOM	9734	N	VAL	I	384	16.605	−13.451	−31.657	1.00	13.24	C	N
  ATOM	9735	CA	VAL	I	384	17.532	−13.584	−32.767	1.00	13.29	C	C
  ATOM	9736	CB	VAL	I	384	17.484	−14.992	−33.387	1.00	13.28	C	C
  ATOM	9737	CG1	VAL	I	384	18.046	−14.970	−34.800	1.00	13.73	C	C
  ATOM	9738	CG2	VAL	I	384	18.251	−15.977	−32.518	1.00	12.76	C	C
  ATOM	9739	C	VAL	I	384	17.292	−12.529	−33.842	1.00	13.57	C	C
  ATOM	9740	O	VAL	I	384	18.239	−12.070	−34.480	1.00	13.31	C	O
  ATOM	9741	N	ASP	I	385	16.038	−12.140	−34.049	1.00	14.07	C	N
  ATOM	9742	CA	ASP	I	385	15.711	−11.380	−35.249	1.00	14.61	C	C
  ATOM	9743	CB	ASP	I	385	15.049	−12.246	−36.318	1.00	14.71	C	C
  ATOM	9744	CG	ASP	I	385	15.608	−11.980	−37.701	1.00	16.69	C	C
  ATOM	9745	OD1	ASP	I	385	16.308	−10.959	−37.872	1.00	18.63	C	O
  ATOM	9746	OD2	ASP	I	385	15.367	−12.800	−38.612	1.00	19.10	C	O
  ATOM	9747	C	ASP	I	385	15.014	−10.029	−35.092	1.00	14.63	C	C
  ATOM	9748	O	ASP	I	385	15.412	−9.054	−35.728	1.00	14.34	C	O
  ATOM	9749	N	ILE	I	386	13.937	−9.980	−34.314	1.00	14.54	C	N
  ATOM	9750	CA	ILE	I	386	13.154	−8.752	−34.212	1.00	14.46	C	C
  ATOM	9751	CB	ILE	I	386	14.074	−7.521	−34.137	1.00	13.83	C	C
  ATOM	9752	CG1	ILE	I	386	14.932	−7.584	−32.875	1.00	13.44	C	C
  ATOM	9753	CD1	ILE	I	386	16.315	−7.018	−33.048	1.00	12.39	C	C
  ATOM	9754	CG2	ILE	I	386	13.253	−6.241	−34.161	1.00	13.51	C	C
  ATOM	9755	C	ILE	I	386	12.274	−8.602	−35.443	1.00	14.73	C	C
  ATOM	9756	O	ILE	I	386	11.048	−8.692	−35.369	1.00	14.68	C	O
  ATOM	9757	N	PHE	I	387	12.917	−8.301	−36.564	1.00	14.71	C	N
  ATOM	9758	CA	PHE	I	387	12.294	−8.428	−37.868	1.00	14.78	C	C
  ATOM	9759	CB	PHE	I	387	12.993	−7.528	−38.876	1.00	14.77	C	C
  ATOM	9760	CG	PHE	I	387	13.269	−6.154	−38.354	1.00	14.75	C	C
  ATOM	9761	CD1	PHE	I	387	14.538	−5.818	−37.909	1.00	15.03	C	C
  ATOM	9762	CE1	PHE	I	387	14.790	−4.572	−37.366	1.00	14.62	C	C
  ATOM	9763	CZ	PHE	I	387	13.743	−3.702	−37.131	1.00	14.55	C	C
  ATOM	9764	CE2	PHE	I	387	12.452	−4.074	−37.463	1.00	14.68	C	C
  ATOM	9765	CD2	PHE	I	387	12.219	−5.303	−38.052	1.00	14.61	C	C
  ATOM	9766	C	PHE	I	387	12.291	−9.864	−38.352	1.00	14.91	C	C
  ATOM	9767	O	PHE	I	387	13.339	−10.461	−38.604	1.00	14.86	C	O
  ATOM	9768	N	ASN	I	388	11.102	−10.448	−38.325	1.00	15.11	C	N
  ATOM	9769	CA	ASN	I	388	10.866	−11.776	−38.850	1.00	15.38	C	C
  ATOM	9770	CB	ASN	I	388	11.522	−12.817	−37.947	1.00	14.86	C	C
  ATOM	9771	CG	ASN	I	388	11.029	−12.733	−36.519	1.00	14.86	C	C
  ATOM	9772	OD1	ASN	I	388	10.004	−13.318	−36.170	1.00	12.80	C	O
  ATOM	9773	ND2	ASN	I	388	11.708	−11.934	−35.707	1.00	15.97	C	N
  ATOM	9774	C	ASN	I	388	9.363	−11.982	−38.843	1.00	16.11	C	C
  ATOM	9775	O	ASN	I	388	8.688	−11.570	−37.902	1.00	15.92	C	O
  ATOM	9776	N	PRO	I	389	8.817	−12.450	−39.969	1.00	16.99	C	N
  ATOM	9777	CA	PRO	I	389	7.464	−12.988	−39.920	1.00	17.40	C	C
  ATOM	9778	CB	PRO	I	389	7.376	−13.815	−41.204	1.00	17.72	C	C
  ATOM	9779	CG	PRO	I	389	8.776	−14.223	−41.477	1.00	17.47	C	C
  ATOM	9780	CD	PRO	I	389	9.618	−13.063	−41.043	1.00	17.05	C	C
  ATOM	9781	C	PRO	I	389	7.304	−13.894	−38.706	1.00	17.86	C	C
  ATOM	9782	O	PRO	I	389	8.297	−14.397	−38.181	1.00	18.45	C	O
  ATOM	9783	N	LYS	I	390	6.068	−14.106	−38.269	1.00	17.97	C	N
  ATOM	9784	CA	LYS	I	390	5.813	−14.937	−37.098	1.00	18.06	C	C
  ATOM	9785	CB	LYS	I	390	6.986	−15.889	−36.844	1.00	17.92	C	C
  ATOM	9786	CG	LYS	I	390	7.066	−17.065	−37.806	1.00	18.58	C	C
  ATOM	9787	CD	LYS	I	390	6.331	−18.283	−37.264	1.00	20.61	C	C
  ATOM	9788	CE	LYS	I	390	6.758	−19.556	−37.982	1.00	21.48	C	C
  ATOM	9789	NZ	LYS	I	390	6.197	−19.645	−39.360	1.00	23.16	C	N
  ATOM	9790	C	LYS	I	390	5.557	−14.087	−35.858	1.00	18.01	C	C
  ATOM	9791	O	LYS	I	390	4.552	−14.267	−35.171	1.00	18.43	C	O
  ATOM	9792	N	TYR	I	391	6.490	−13.192	−35.548	1.00	17.68	C	N
  ATOM	9793	CA	TYR	I	391	6.267	−12.216	−34.492	1.00	17.33	C	C
  ATOM	9794	CB	TYR	I	391	7.026	−12.599	−33.224	1.00	17.42	C	C
  ATOM	9795	CG	TYR	I	391	6.220	−12.376	−31.971	1.00	17.27	C	C
  ATOM	9796	CD1	TYR	I	391	4.863	−12.657	−31.951	1.00	17.29	C	C
  ATOM	9797	CE1	TYR	I	391	4.108	−12.437	−30.822	1.00	17.32	C	C
  ATOM	9798	CZ	TYR	I	391	4.678	−11.809	−29.739	1.00	16.51	C	C
  ATOM	9799	OH	TYR	I	391	3.934	−11.601	−28.602	1.00	16.65	C	O
  ATOM	9800	CE2	TYR	I	391	6.005	−11.441	−29.765	1.00	16.52	C	C
  ATOM	9801	CD2	TYR	I	391	6.756	−11.689	−30.893	1.00	17.24	C	C
  ATOM	9802	C	TYR	I	391	6.623	−10.796	−34.910	1.00	17.43	C	C
  ATOM	9803	O	TYR	I	391	7.786	−10.491	−35.175	1.00	17.70	C	O
  ATOM	9804	N	ASP	I	392	5.647	−9.899	−34.813	1.00	17.56	C	N
  ATOM	9805	CA	ASP	I	392	5.944	−8.487	−34.609	1.00	17.69	C	C
  ATOM	9806	CB	ASP	I	392	4.779	−7.590	−35.045	1.00	17.89	C	C
  ATOM	9807	CG	ASP	I	392	3.556	−8.380	−35.472	1.00	18.86	C	C
  ATOM	9808	OD1	ASP	I	392	2.911	−8.993	−34.596	1.00	20.34	C	O
  ATOM	9809	OD2	ASP	I	392	3.162	−8.272	−36.653	1.00	18.51	C	O
  ATOM	9810	C	ASP	I	392	6.342	−8.188	−33.169	1.00	17.11	C	C
  ATOM	9811	O	ASP	I	392	5.674	−8.609	−32.222	1.00	17.04	C	O
  ATOM	9812	N	CYS	I	393	7.356	−7.342	−33.026	1.00	16.33	C	N
  ATOM	9813	CA	CYS	I	393	8.347	−7.491	−31.975	1.00	16.17	C	C
  ATOM	9814	CB	CYS	I	393	9.656	−8.022	−32.554	1.00	16.11	C	C
  ATOM	9815	SG	CYS	I	393	10.738	−8.792	−31.342	1.00	20.23	C	S
  ATOM	9816	C	CYS	I	393	8.587	−6.139	−31.330	1.00	15.37	C	C
  ATOM	9817	O	CYS	I	393	9.066	−5.209	−31.980	1.00	15.15	C	O
  ATOM	9818	N	LYS	I	394	8.077	−5.982	−30.115	1.00	14.91	C	N
  ATOM	9819	CA	LYS	I	394	7.988	−4.668	−29.502	1.00	14.50	C	C
  ATOM	9820	CB	LYS	I	394	7.163	−4.724	−28.214	1.00	14.60	C	C
  ATOM	9821	CG	LYS	I	394	5.909	−5.591	−28.313	1.00	16.44	C	C
  ATOM	9822	CD	LYS	I	394	4.799	−5.101	−27.382	1.00	20.45	C	C
  ATOM	9823	CE	LYS	I	394	4.989	−5.604	−25.955	1.00	23.05	C	C
  ATOM	9824	NZ	LYS	I	394	5.685	−4.608	−25.094	1.00	24.13	C	N
  ATOM	9825	C	LYS	I	394	9.370	−4.087	−29.239	1.00	14.00	C	C
  ATOM	9826	O	LYS	I	394	10.260	−4.760	−28.720	1.00	14.14	C	O
  ATOM	9827	N	ILE	I	395	9.497	−2.797	−29.507	1.00	13.28	C	N
  ATOM	9828	CA	ILE	I	395	10.750	−2.193	−29.919	1.00	12.89	C	C
  ATOM	9829	CB	ILE	I	395	10.960	−2.334	−31.435	1.00	12.75	C	C
  ATOM	9830	CG1	ILE	I	395	11.556	−3.695	−31.786	1.00	13.58	C	C
  ATOM	9831	CD1	ILE	I	395	11.347	−4.084	−33.236	1.00	15.33	C	C
  ATOM	9832	CG2	ILE	I	395	11.838	−1.216	−31.951	1.00	12.16	C	C
  ATOM	9833	C	ILE	I	395	10.534	−0.722	−29.648	1.00	13.15	C	C
  ATOM	9834	O	ILE	I	395	9.437	−0.210	−29.867	1.00	13.45	C	O
  ATOM	9835	N	MET	I	396	11.597	−0.002	−29.330	1.00	13.06	C	N
  ATOM	9836	CA	MET	I	396	11.526	1.433	−29.454	1.00	13.00	C	C
  ATOM	9837	CB	MET	I	396	11.421	2.114	−28.088	1.00	13.34	C	C
  ATOM	9838	CG	MET	I	396	12.738	2.594	−27.506	1.00	14.30	C	C
  ATOM	9839	SD	MET	I	396	12.483	3.421	−25.925	1.00	18.50	C	S
  ATOM	9840	CE	MET	I	396	11.067	2.515	−25.304	1.00	17.80	C	C
  ATOM	9841	C	MET	I	396	12.646	2.009	−30.288	1.00	12.96	C	C
  ATOM	9842	O	MET	I	396	13.704	1.405	−30.453	1.00	13.04	C	O
  ATOM	9843	N	THR	I	397	12.360	3.167	−30.862	1.00	12.78	C	N
  ATOM	9844	CA	THR	I	397	13.158	3.744	−31.917	1.00	12.51	C	C
  ATOM	9845	CB	THR	I	397	12.261	4.048	−33.134	1.00	12.39	C	C
  ATOM	9846	OG1	THR	I	397	12.048	2.845	−33.883	1.00	12.50	C	O
  ATOM	9847	CG2	THR	I	397	12.895	5.107	−34.026	1.00	12.55	C	C
  ATOM	9848	C	THR	I	397	13.633	5.062	−31.330	1.00	12.58	C	C
  ATOM	9849	O	THR	I	397	12.815	5.911	−31.001	1.00	12.88	C	O
  ATOM	9850	N	SER	I	398	14.919	5.217	−31.088	1.00	12.55	C	N
  ATOM	9851	CA	SER	I	398	15.538	6.442	−31.506	1.00	12.76	C	C
  ATOM	9852	CB	SER	I	398	16.509	6.920	−30.432	1.00	12.52	C	C
  ATOM	9853	OG	SER	I	398	17.486	7.787	−30.978	1.00	12.72	C	O
  ATOM	9854	C	SER	I	398	16.262	5.826	−32.632	1.00	12.99	C	C
  ATOM	9855	O	SER	I	398	16.219	6.314	−33.761	1.00	13.13	C	O
  ATOM	9856	N	LYS	I	399	16.463	4.540	−32.418	1.00	13.01	C	N
  ATOM	9857	CA	LYS	I	399	17.619	4.000	−32.989	1.00	13.29	C	C
  ATOM	9858	CB	LYS	I	399	17.475	4.221	−34.500	1.00	13.79	C	C
  ATOM	9859	CG	LYS	I	399	15.997	4.359	−34.942	1.00	14.34	C	C
  ATOM	9860	CD	LYS	I	399	15.854	4.556	−36.445	1.00	16.43	C	C
  ATOM	9861	CE	LYS	I	399	15.114	3.394	−37.093	1.00	17.37	C	C
  ATOM	9862	NZ	LYS	I	399	15.524	3.199	−38.511	1.00	16.62	C	N
  ATOM	9863	C	LYS	I	399	18.632	4.961	−32.349	1.00	13.09	C	C
  ATOM	9864	O	LYS	I	399	19.670	5.257	−32.934	1.00	12.87	C	O
  ATOM	9865	N	THR	I	400	18.236	5.572	−31.225	1.00	13.04	C	N
  ATOM	9866	CA	THR	I	400	19.072	6.571	−30.513	1.00	13.38	C	C
  ATOM	9867	CB	THR	I	400	18.218	7.723	−29.906	1.00	13.74	C	C
  ATOM	9868	OG1	THR	I	400	16.861	7.632	−30.365	1.00	14.38	C	O
  ATOM	9869	CG2	THR	I	400	18.798	9.072	−30.296	1.00	14.32	C	C
  ATOM	9870	C	THR	I	400	19.991	5.980	−29.408	1.00	13.20	C	C
  ATOM	9871	O	THR	I	400	19.748	4.866	−28.945	1.00	13.12	C	O
  ATOM	9872	N	ASP	I	401	20.881	6.801	−28.834	1.00	12.97	C	N
  ATOM	9873	CA	ASP	I	401	22.197	6.333	−28.331	1.00	12.50	C	C
  ATOM	9874	CB	ASP	I	401	23.307	7.270	−28.816	1.00	12.73	C	C
  ATOM	9875	CG	ASP	I	401	24.212	6.623	−29.841	1.00	13.98	C	C
  ATOM	9876	OD1	ASP	I	401	23.677	6.029	−30.801	1.00	16.55	C	O
  ATOM	9877	OD2	ASP	I	401	25.430	6.903	−29.814	1.00	14.80	C	O
  ATOM	9878	C	ASP	I	401	22.414	6.066	−26.816	1.00	12.13	C	C
  ATOM	9879	O	ASP	I	401	21.541	6.376	−26.002	1.00	12.31	C	O
  ATOM	9880	N	VAL	I	402	23.721	6.022	−26.502	1.00	11.49	C	N
  ATOM	9881	CA	VAL	I	402	24.382	5.380	−25.316	1.00	10.74	C	C
  ATOM	9882	CB	VAL	I	402	23.454	5.112	−24.128	1.00	10.60	C	C
  ATOM	9883	CG1	VAL	I	402	24.200	4.335	−23.060	1.00	11.26	C	C
  ATOM	9884	CG2	VAL	I	402	22.942	6.425	−23.556	1.00	10.99	C	C
  ATOM	9885	C	VAL	I	402	25.452	4.251	−25.504	1.00	10.24	C	C
  ATOM	9886	O	VAL	I	402	25.773	3.895	−26.638	1.00	10.30	C	O
  ATOM	9887	N	SER	I	403	25.962	3.665	−24.400	1.00	9.76	C	N
  ATOM	9888	CA	SER	I	403	27.019	2.595	−24.456	1.00	9.18	C	C
  ATOM	9889	CB	SER	I	403	28.324	3.145	−25.036	1.00	9.41	C	C
  ATOM	9890	OG	SER	I	403	28.274	4.554	−25.165	1.00	10.82	C	O
  ATOM	9891	C	SER	I	403	27.325	1.652	−23.238	1.00	8.51	C	C
  ATOM	9892	O	SER	I	403	27.347	2.099	−22.088	1.00	8.30	C	O
  ATOM	9893	N	SER	I	404	27.642	0.376	−23.530	1.00	8.35	C	N
  ATOM	9894	CA	SER	I	404	28.574	−0.482	−22.733	1.00	8.18	C	C
  ATOM	9895	CB	SER	I	404	28.123	−0.585	−21.276	1.00	8.18	C	C
  ATOM	9896	OG	SER	I	404	27.698	−1.901	−20.968	1.00	8.83	C	O
  ATOM	9897	C	SER	I	404	28.789	−1.907	−23.310	1.00	7.62	C	C
  ATOM	9898	O	SER	I	404	28.422	−2.171	−24.455	1.00	7.57	C	O
  ATOM	9899	N	SER	I	405	29.368	−2.817	−22.514	1.00	7.08	C	N
  ATOM	9900	CA	SER	I	405	29.672	−4.192	−22.973	1.00	6.53	C	C
  ATOM	9901	CB	SER	I	405	31.139	−4.335	−23.400	1.00	6.42	C	C
  ATOM	9902	OG	SER	I	405	31.467	−5.695	−23.651	1.00	5.66	C	O
  ATOM	9903	C	SER	I	405	29.300	−5.333	−22.012	1.00	6.28	C	C
  ATOM	9904	O	SER	I	405	29.334	−5.169	−20.791	1.00	5.98	C	O
  ATOM	9905	N	VAL	I	406	29.215	−6.535	−22.576	1.00	6.22	C	N
  ATOM	9906	CA	VAL	I	406	28.714	−7.705	−21.866	1.00	6.50	C	C
  ATOM	9907	CB	VAL	I	406	27.208	−7.894	−22.099	1.00	6.45	C	C
  ATOM	9908	CG1	VAL	I	406	26.661	−8.972	−21.181	1.00	7.66	C	C
  ATOM	9909	CG2	VAL	I	406	26.470	−6.577	−21.903	1.00	7.38	C	C
  ATOM	9910	C	VAL	I	406	29.424	−8.942	−22.388	1.00	6.24	C	C
  ATOM	9911	O	VAL	I	406	29.397	−9.228	−23.584	1.00	6.14	C	O
  ATOM	9912	N	ILE	I	407	30.041	−9.689	−21.485	1.00	6.32	C	N
  ATOM	9913	CA	ILE	I	407	30.831	−10.838	−21.881	1.00	6.60	C	C
  ATOM	9914	CB	ILE	I	407	32.035	−11.021	−20.959	1.00	6.27	C	C
  ATOM	9915	CG1	ILE	I	407	33.112	−9.989	−21.295	1.00	6.19	C	C
  ATOM	9916	CD1	ILE	I	407	33.720	−9.323	−20.073	1.00	8.34	C	C
  ATOM	9917	CG2	ILE	I	407	32.567	−12.438	−21.053	1.00	6.42	C	C
  ATOM	9918	C	ILE	I	407	29.995	−12.110	−21.882	1.00	7.20	C	C
  ATOM	9919	O	ILE	I	407	29.246	−12.376	−20.944	1.00	7.42	C	O
  ATOM	9920	N	THR	I	408	30.163	−12.914	−22.925	1.00	7.57	C	N
  ATOM	9921	CA	THR	I	408	29.355	−14.113	−23.103	1.00	8.19	C	C
  ATOM	9922	CB	THR	I	408	28.681	−14.138	−24.483	1.00	8.15	C	C
  ATOM	9923	OG1	THR	I	408	29.684	−14.218	−25.503	1.00	8.88	C	O
  ATOM	9924	CG2	THR	I	408	27.853	−12.888	−24.693	1.00	7.93	C	C
  ATOM	9925	C	THR	I	408	30.192	−15.376	−22.966	1.00	8.55	C	C
  ATOM	9926	O	THR	I	408	31.419	−15.333	−23.065	1.00	9.07	C	O
  ATOM	9927	N	SER	I	409	29.503	−16.512	−22.970	1.00	8.70	C	N
  ATOM	9928	CA	SER	I	409	30.146	−17.813	−22.838	1.00	9.20	C	C
  ATOM	9929	CB	SER	I	409	29.126	−18.935	−23.044	1.00	9.72	C	C
  ATOM	9930	OG	SER	I	409	27.946	−18.700	−22.297	1.00	10.75	C	O
  ATOM	9931	C	SER	I	409	31.268	−17.958	−23.848	1.00	9.01	C	C
  ATOM	9932	O	SER	I	409	32.299	−18.571	−23.567	1.00	9.02	C	O
  ATOM	9933	N	LEU	I	410	31.027	−17.458	−25.053	1.00	8.91	C	N
  ATOM	9934	CA	LEU	I	410	31.814	−17.858	−26.204	1.00	9.29	C	C
  ATOM	9935	CB	LEU	I	410	31.024	−18.828	−27.081	1.00	9.61	C	C
  ATOM	9936	CG	LEU	I	410	31.702	−20.180	−27.323	1.00	9.70	C	C
  ATOM	9937	CD1	LEU	I	410	31.975	−20.908	−26.014	1.00	11.11	C	C
  ATOM	9938	CD2	LEU	I	410	30.895	−21.057	−28.274	1.00	9.16	C	C
  ATOM	9939	C	LEU	I	410	32.250	−16.644	−27.009	1.00	9.12	C	C
  ATOM	9940	O	LEU	I	410	32.844	−16.774	−28.077	1.00	9.08	C	O
  ATOM	9941	N	GLY	I	411	32.016	−15.462	−26.454	1.00	9.03	C	N
  ATOM	9942	CA	GLY	I	411	32.612	−14.247	−26.984	1.00	8.44	C	C
  ATOM	9943	C	GLY	I	411	32.234	−13.047	−26.146	1.00	7.91	C	C
  ATOM	9944	O	GLY	I	411	32.175	−13.131	−24.921	1.00	7.85	C	O
  ATOM	9945	N	ALA	I	412	31.868	−11.961	−26.816	1.00	7.30	C	N
  ATOM	9946	CA	ALA	I	412	31.416	−10.757	−26.130	1.00	6.92	C	C
  ATOM	9947	CB	ALA	I	412	32.609	−9.925	−25.672	1.00	6.90	C	C
  ATOM	9948	C	ALA	I	412	30.502	−9.934	−27.029	1.00	6.99	C	C
  ATOM	9949	O	ALA	I	412	30.597	−10.004	−28.255	1.00	6.94	C	O
  ATOM	9950	N	ILE	I	413	29.567	−9.216	−26.418	1.00	7.29	C	N
  ATOM	9951	CA	ILE	I	413	28.808	−8.200	−27.136	1.00	7.49	C	C
  ATOM	9952	CB	ILE	I	413	27.296	−8.285	−26.846	1.00	7.24	C	C
  ATOM	9953	CG1	ILE	I	413	26.703	−9.550	−27.480	1.00	7.18	C	C
  ATOM	9954	CD1	ILE	I	413	25.397	−9.315	−28.241	1.00	7.70	C	C
  ATOM	9955	CG2	ILE	I	413	26.585	−7.051	−27.397	1.00	7.70	C	C
  ATOM	9956	C	ILE	I	413	29.304	−6.811	−26.776	1.00	7.94	C	C
  ATOM	9957	O	ILE	I	413	29.806	−6.591	−25.674	1.00	8.39	C	O
  ATOM	9958	N	VAL	I	414	29.155	−5.871	−27.703	1.00	8.22	C	N
  ATOM	9959	CA	VAL	I	414	29.498	−4.485	−27.420	1.00	8.77	C	C
  ATOM	9960	CB	VAL	I	414	30.965	−4.158	−27.782	1.00	8.57	C	C
  ATOM	9961	CG1	VAL	I	414	31.293	−4.627	−29.197	1.00	9.12	C	C
  ATOM	9962	CG2	VAL	I	414	31.245	−2.669	−27.607	1.00	8.90	C	C
  ATOM	9963	C	VAL	I	414	28.536	−3.470	−28.028	1.00	8.92	C	C
  ATOM	9964	O	VAL	I	414	28.246	−3.497	−29.227	1.00	9.00	C	O
  ATOM	9965	N	SER	I	415	27.947	−2.665	−27.152	1.00	8.97	C	N
  ATOM	9966	CA	SER	I	415	27.023	−1.623	−27.552	1.00	9.02	C	C
  ATOM	9967	CB	SER	I	415	25.805	−1.623	−26.629	1.00	8.98	C	C
  ATOM	9968	OG	SER	I	415	25.203	−2.903	−26.581	1.00	9.54	C	O
  ATOM	9969	C	SER	I	415	27.727	−0.277	−27.480	1.00	9.36	C	C
  ATOM	9970	O	SER	I	415	27.996	0.230	−26.392	1.00	9.61	C	O
  ATOM	9971	N	CYS	I	416	28.219	0.177	−28.626	1.00	9.57	C	N
  ATOM	9972	CA	CYS	I	416	28.920	1.447	−28.701	1.00	9.61	C	C
  ATOM	9973	CB	CYS	I	416	30.167	1.320	−29.572	1.00	9.62	C	C
  ATOM	9974	SG	CYS	I	416	31.508	2.403	−29.060	1.00	11.33	C	S
  ATOM	9975	C	CYS	I	416	28.011	2.519	−29.270	1.00	9.61	C	C
  ATOM	9976	O	CYS	I	416	27.619	2.458	−30.434	1.00	9.80	C	O
  ATOM	9977	N	TYR	I	417	27.662	3.493	−28.441	1.00	9.48	C	N
  ATOM	9978	CA	TYR	I	417	26.667	4.475	−28.829	1.00	9.28	C	C
  ATOM	9979	CB	TYR	I	417	25.305	4.117	−28.235	1.00	9.17	C	C
  ATOM	9980	CG	TYR	I	417	24.629	2.955	−28.924	1.00	8.71	C	C
  ATOM	9981	CD1	TYR	I	417	23.902	2.024	−28.199	1.00	8.54	C	C
  ATOM	9982	CE1	TYR	I	417	23.228	0.999	−28.830	1.00	9.56	C	C
  ATOM	9983	CZ	TYR	I	417	23.289	0.886	−30.201	1.00	9.83	C	C
  ATOM	9984	OH	TYR	I	417	22.658	−0.162	−30.829	1.00	10.51	C	O
  ATOM	9985	CE2	TYR	I	417	24.025	1.783	−30.942	1.00	9.36	C	C
  ATOM	9986	CD2	TYR	I	417	24.675	2.818	−30.305	1.00	8.95	C	C
  ATOM	9987	C	TYR	I	417	27.076	5.885	−28.422	1.00	9.35	C	C
  ATOM	9988	O	TYR	I	417	28.046	6.075	−27.687	1.00	9.11	C	O
  ATOM	9989	N	GLY	I	418	26.357	6.872	−28.946	1.00	9.71	C	N
  ATOM	9990	CA	GLY	I	418	26.662	8.270	−28.679	1.00	9.95	C	C
  ATOM	9991	C	GLY	I	418	28.094	8.602	−29.035	1.00	10.09	C	C
  ATOM	9992	O	GLY	I	418	28.623	8.112	−30.033	1.00	10.17	C	O
  ATOM	9993	N	LYS	I	419	28.768	9.307	−28.136	1.00	10.17	C	N
  ATOM	9994	CA	LYS	I	419	30.104	9.810	−28.415	1.00	10.50	C	C
  ATOM	9995	CB	LYS	I	419	30.381	11.077	−27.607	1.00	11.09	C	C
  ATOM	9996	CG	LYS	I	419	29.942	12.351	−28.300	1.00	12.94	C	C
  ATOM	9997	CD	LYS	I	419	30.697	13.553	−27.770	1.00	15.52	C	C
  ATOM	9998	CE	LYS	I	419	30.546	14.735	−28.708	1.00	17.07	C	C
  ATOM	9999	NZ	LYS	I	419	29.200	14.756	−29.349	1.00	19.30	C	N
  ATOM	10000	C	LYS	I	419	31.201	8.777	−28.168	1.00	10.23	C	C
  ATOM	10001	O	LYS	I	419	32.380	9.063	−28.374	1.00	10.58	C	O
  ATOM	10002	N	THR	I	420	30.823	7.592	−27.697	1.00	10.10	C	N
  ATOM	10003	CA	THR	I	420	31.789	6.687	−27.076	1.00	9.74	C	C
  ATOM	10004	CB	THR	I	420	31.106	5.656	−26.158	1.00	9.28	C	C
  ATOM	10005	OG1	THR	I	420	29.766	6.076	−25.878	1.00	9.21	C	O
  ATOM	10006	CG2	THR	I	420	31.870	5.521	−24.851	1.00	9.03	C	C
  ATOM	10007	C	THR	I	420	32.671	5.966	−28.096	1.00	9.95	C	C
  ATOM	10008	O	THR	I	420	32.289	5.800	−29.254	1.00	10.35	C	O
  ATOM	10009	N	LYS	I	421	33.880	5.608	−27.674	1.00	10.07	C	N
  ATOM	10010	CA	LYS	I	421	34.808	4.863	−28.521	1.00	10.21	C	C
  ATOM	10011	CB	LYS	I	421	36.194	5.513	−28.495	1.00	10.30	C	C
  ATOM	10012	CG	LYS	I	421	36.445	6.496	−29.626	1.00	12.43	C	C
  ATOM	10013	CD	LYS	I	421	37.766	7.225	−29.441	1.00	15.12	C	C
  ATOM	10014	CE	LYS	I	421	37.752	8.578	−30.134	1.00	15.21	C	C
  ATOM	10015	NZ	LYS	I	421	38.779	9.500	−29.575	1.00	15.98	C	N
  ATOM	10016	C	LYS	I	421	34.908	3.412	−28.063	1.00	10.09	C	C
  ATOM	10017	O	LYS	I	421	34.979	3.137	−26.866	1.00	10.36	C	O
  ATOM	10018	N	CYS	I	422	34.937	2.486	−29.017	1.00	9.81	C	N
  ATOM	10019	CA	CYS	I	422	35.063	1.075	−28.681	1.00	9.56	C	C
  ATOM	10020	CB	CYS	I	422	33.696	0.396	−28.633	1.00	9.72	C	C
  ATOM	10021	SG	CYS	I	422	32.479	1.300	−27.664	1.00	11.42	C	S
  ATOM	10022	C	CYS	I	422	36.012	0.311	−29.590	1.00	9.18	C	C
  ATOM	10023	O	CYS	I	422	36.111	0.582	−30.787	1.00	9.27	C	O
  ATOM	10024	N	THR	I	423	36.636	−0.710	−29.016	1.00	8.93	C	N
  ATOM	10025	CA	THR	I	423	37.825	−1.322	−29.583	1.00	8.64	C	C
  ATOM	10026	CB	THR	I	423	39.104	−0.757	−28.940	1.00	8.32	C	C
  ATOM	10027	OG1	THR	I	423	39.059	0.675	−28.954	1.00	7.97	C	O
  ATOM	10028	CG2	THR	I	423	40.336	−1.230	−29.695	1.00	8.36	C	C
  ATOM	10029	C	THR	I	423	37.771	−2.810	−29.287	1.00	8.86	C	C
  ATOM	10030	O	THR	I	423	37.514	−3.214	−28.153	1.00	9.26	C	O
  ATOM	10031	N	ALA	I	424	37.993	−3.625	−30.310	1.00	8.74	C	N
  ATOM	10032	CA	ALA	I	424	38.356	−5.018	−30.097	1.00	8.79	C	C
  ATOM	10033	CB	ALA	I	424	37.512	−5.927	−30.977	1.00	8.94	C	C
  ATOM	10034	C	ALA	I	424	39.839	−5.233	−30.371	1.00	8.84	C	C
  ATOM	10035	O	ALA	I	424	40.316	−4.985	−31.477	1.00	9.24	C	O
  ATOM	10036	N	SER	I	425	40.570	−5.661	−29.347	1.00	8.81	C	N
  ATOM	10037	CA	SER	I	425	41.990	−5.958	−29.492	1.00	8.85	C	C
  ATOM	10038	CB	SER	I	425	42.803	−5.192	−28.446	1.00	8.94	C	C
  ATOM	10039	OG	SER	I	425	42.091	−4.060	−27.976	1.00	7.69	C	O
  ATOM	10040	C	SER	I	425	42.253	−7.456	−29.368	1.00	9.01	C	C
  ATOM	10041	O	SER	I	425	41.541	−8.163	−28.656	1.00	8.63	C	O
  ATOM	10042	N	ASN	I	426	43.246	−7.944	−30.102	1.00	9.54	C	N
  ATOM	10043	CA	ASN	I	426	43.519	−9.374	−30.153	1.00	10.19	C	C
  ATOM	10044	CB	ASN	I	426	44.105	−9.764	−31.511	1.00	9.77	C	C
  ATOM	10045	CG	ASN	I	426	45.597	−9.506	−31.599	1.00	9.43	C	C
  ATOM	10046	OD1	ASN	I	426	46.249	−9.211	−30.597	1.00	9.01	C	O
  ATOM	10047	ND2	ASN	I	426	46.146	−9.616	−32.803	1.00	9.01	C	N
  ATOM	10048	C	ASN	I	426	44.434	−9.853	−29.029	1.00	11.16	C	C
  ATOM	10049	O	ASN	I	426	44.674	−9.138	−28.056	1.00	11.06	C	O
  ATOM	10050	N	LYS	I	427	44.921	−11.083	−29.170	1.00	12.38	C	N
  ATOM	10051	CA	LYS	I	427	45.803	−11.703	−28.185	1.00	13.52	C	C
  ATOM	10052	CB	LYS	I	427	46.418	−12.978	−28.765	1.00	14.00	C	C
  ATOM	10053	CG	LYS	I	427	45.683	−14.255	−28.398	1.00	16.18	C	C
  ATOM	10054	CD	LYS	I	427	46.510	−15.478	−28.758	1.00	18.24	C	C
  ATOM	10055	CE	LYS	I	427	46.211	−16.641	−27.828	1.00	19.72	C	C
  ATOM	10056	NZ	LYS	I	427	46.794	−16.434	−26.474	1.00	21.43	C	N
  ATOM	10057	C	LYS	I	427	46.915	−10.758	−27.741	1.00	13.71	C	C
  ATOM	10058	O	LYS	I	427	47.180	−10.611	−26.547	1.00	13.63	C	O
  ATOM	10059	N	ASN	I	428	47.634	−10.210	−28.716	1.00	14.28	C	N
  ATOM	10060	CA	ASN	I	428	48.816	−9.400	−28.447	1.00	14.60	C	C
  ATOM	10061	CB	ASN	I	428	49.709	−9.331	−29.689	1.00	14.57	C	C
  ATOM	10062	CG	ASN	I	428	49.589	−10.565	−30.563	1.00	13.24	C	C
  ATOM	10063	OD1	ASN	I	428	49.765	−11.690	−30.096	1.00	9.74	C	O
  ATOM	10064	ND2	ASN	I	428	49.319	−10.358	−31.847	1.00	12.83	C	N
  ATOM	10065	C	ASN	I	428	48.466	−7.989	−27.982	1.00	14.83	C	C
  ATOM	10066	O	ASN	I	428	49.330	−7.255	−27.499	1.00	15.25	C	O
  ATOM	10067	N	ARG	I	429	47.225	−7.580	−28.226	1.00	14.78	C	N
  ATOM	10068	CA	ARG	I	429	46.775	−6.234	−27.885	1.00	14.74	C	C
  ATOM	10069	CB	ARG	I	429	47.695	−5.603	−26.837	1.00	14.93	C	C
  ATOM	10070	CG	ARG	I	429	47.475	−6.121	−25.424	1.00	16.26	C	C
  ATOM	10071	CD	ARG	I	429	46.452	−5.279	−24.677	1.00	19.79	C	C
  ATOM	10072	NE	ARG	I	429	45.979	−5.940	−23.464	1.00	22.68	C	N
  ATOM	10073	CZ	ARG	I	429	46.735	−6.172	−22.396	1.00	23.54	C	C
  ATOM	10074	NH1	ARG	I	429	48.013	−5.817	−22.394	1.00	22.87	C	N
  ATOM	10075	NH2	ARG	I	429	46.219	−6.777	−21.335	1.00	23.53	C	N
  ATOM	10076	C	ARG	I	429	46.689	−5.339	−29.117	1.00	14.35	C	C
  ATOM	10077	O	ARG	I	429	46.093	−4.262	−29.073	1.00	14.62	C	O
  ATOM	10078	N	GLY	I	430	47.270	−5.798	−30.221	1.00	13.67	C	N
  ATOM	10079	CA	GLY	I	430	46.898	−5.304	−31.540	1.00	12.80	C	C
  ATOM	10080	C	GLY	I	430	45.397	−5.149	−31.683	1.00	12.11	C	C
  ATOM	10081	O	GLY	I	430	44.634	−6.038	−31.306	1.00	12.18	C	O
  ATOM	10082	N	ILE	I	431	44.972	−4.001	−32.199	1.00	11.58	C	N
  ATOM	10083	CA	ILE	I	431	43.552	−3.678	−32.300	1.00	10.76	C	C
  ATOM	10084	CB	ILE	I	431	43.321	−2.162	−32.138	1.00	10.43	C	C
  ATOM	10085	CG1	ILE	I	431	43.649	−1.718	−30.711	1.00	10.95	C	C
  ATOM	10086	CD1	ILE	I	431	44.264	−0.337	−30.628	1.00	12.08	C	C
  ATOM	10087	CG2	ILE	I	431	41.892	−1.796	−32.507	1.00	10.07	C	C
  ATOM	10088	C	ILE	I	431	43.011	−4.108	−33.660	1.00	10.68	C	C
  ATOM	10089	O	ILE	I	431	43.474	−3.623	−34.693	1.00	10.40	C	O
  ATOM	10090	N	ILE	I	432	42.063	−5.041	−33.669	1.00	10.90	C	N
  ATOM	10091	CA	ILE	I	432	41.497	−5.518	−34.931	1.00	11.42	C	C
  ATOM	10092	CB	ILE	I	432	41.106	−7.008	−34.884	1.00	11.63	C	C
  ATOM	10093	CG1	ILE	I	432	41.784	−7.712	−33.709	1.00	12.68	C	C
  ATOM	10094	CD1	ILE	I	432	41.172	−9.055	−33.369	1.00	13.89	C	C
  ATOM	10095	CG2	ILE	I	432	41.453	−7.689	−36.201	1.00	12.24	C	C
  ATOM	10096	C	ILE	I	432	40.290	−4.703	−35.381	1.00	11.41	C	C
  ATOM	10097	O	ILE	I	432	40.172	−4.362	−36.558	1.00	11.63	C	O
  ATOM	10098	N	LYS	I	433	39.315	−4.555	−34.492	1.00	11.52	C	N
  ATOM	10099	CA	LYS	I	433	38.076	−3.878	−34.848	1.00	11.96	C	C
  ATOM	10100	CB	LYS	I	433	36.864	−4.767	−34.566	1.00	12.31	C	C
  ATOM	10101	CG	LYS	I	433	35.552	−4.201	−35.092	1.00	14.42	C	C
  ATOM	10102	CD	LYS	I	433	34.622	−5.301	−35.578	1.00	16.74	C	C
  ATOM	10103	CE	LYS	I	433	33.367	−4.723	−36.216	1.00	17.08	C	C
  ATOM	10104	NZ	LYS	I	433	33.135	−5.263	−37.585	1.00	17.30	C	N
  ATOM	10105	C	LYS	I	433	37.934	−2.543	−34.128	1.00	11.65	C	C
  ATOM	10106	O	LYS	I	433	38.620	−2.281	−33.140	1.00	11.48	C	O
  ATOM	10107	N	THR	I	434	37.059	−1.691	−34.651	1.00	11.28	C	N
  ATOM	10108	CA	THR	I	434	36.764	−0.407	−34.027	1.00	11.21	C	C
  ATOM	10109	CB	THR	I	434	37.809	0.653	−34.414	1.00	11.30	C	C
  ATOM	10110	OG1	THR	I	434	37.324	1.955	−34.062	1.00	11.83	C	O
  ATOM	10111	CG2	THR	I	434	38.088	0.608	−35.910	1.00	11.84	C	C
  ATOM	10112	C	THR	I	434	35.380	0.083	−34.446	1.00	10.94	C	C
  ATOM	10113	O	THR	I	434	34.982	−0.085	−35.597	1.00	10.93	C	O
  ATOM	10114	N	PHE	I	435	34.604	0.572	−33.484	1.00	11.10	C	N
  ATOM	10115	CA	PHE	I	435	33.176	0.281	−33.466	1.00	11.96	C	C
  ATOM	10116	CB	PHE	I	435	32.726	−0.248	−32.106	1.00	11.51	C	C
  ATOM	10117	CG	PHE	I	435	32.896	−1.732	−31.957	1.00	11.19	C	C
  ATOM	10118	CD1	PHE	I	435	33.805	−2.246	−31.047	1.00	10.86	C	C
  ATOM	10119	CE1	PHE	I	435	34.022	−3.608	−30.957	1.00	10.24	C	C
  ATOM	10120	CZ	PHE	I	435	33.375	−4.467	−31.823	1.00	9.89	C	C
  ATOM	10121	CE2	PHE	I	435	32.512	−3.963	−32.774	1.00	10.78	C	C
  ATOM	10122	CD2	PHE	I	435	32.300	−2.599	−32.858	1.00	11.14	C	C
  ATOM	10123	C	PHE	I	435	32.255	1.381	−33.984	1.00	13.00	C	C
  ATOM	10124	O	PHE	I	435	32.168	2.466	−33.407	1.00	13.03	C	O
  ATOM	10125	N	SER	I	436	31.429	1.001	−34.954	1.00	13.89	C	N
  ATOM	10126	CA	SER	I	436	30.556	1.929	−35.657	1.00	14.67	C	C
  ATOM	10127	CB	SER	I	436	30.282	1.417	−37.074	1.00	15.04	C	C
  ATOM	10128	OG	SER	I	436	30.877	2.256	−38.049	1.00	16.58	C	O
  ATOM	10129	C	SER	I	436	29.240	2.105	−34.903	1.00	14.75	C	C
  ATOM	10130	O	SER	I	436	28.192	1.626	−35.340	1.00	14.75	C	O
  ATOM	10131	N	ASN	I	437	29.302	2.785	−33.764	1.00	14.44	C	N
  ATOM	10132	CA	ASN	I	437	28.124	3.433	−33.203	1.00	14.35	C	C
  ATOM	10133	CB	ASN	I	437	27.891	4.781	−33.881	1.00	14.75	C	C
  ATOM	10134	CG	ASN	I	437	26.889	5.641	−33.139	1.00	15.51	C	C
  ATOM	10135	OD1	ASN	I	437	27.054	5.920	−31.951	1.00	16.85	C	O
  ATOM	10136	ND2	ASN	I	437	25.878	6.120	−33.856	1.00	16.10	C	N
  ATOM	10137	C	ASN	I	437	26.885	2.558	−33.345	1.00	13.69	C	C
  ATOM	10138	O	ASN	I	437	25.912	2.941	−33.995	1.00	13.40	C	O
  ATOM	10139	N	GLY	I	438	26.957	1.358	−32.782	1.00	13.39	C	N
  ATOM	10140	CA	GLY	I	438	25.931	0.345	−32.986	1.00	12.92	C	C
  ATOM	10141	C	GLY	I	438	26.000	−0.743	−31.934	1.00	12.72	C	C
  ATOM	10142	O	GLY	I	438	26.154	−0.459	−30.747	1.00	12.83	C	O
  ATOM	10143	N	CYS	I	439	25.949	−1.996	−32.375	1.00	12.17	C	N
  ATOM	10144	CA	CYS	I	439	26.014	−3.126	−31.456	1.00	11.52	C	C
  ATOM	10145	CB	CYS	I	439	24.672	−3.321	−30.750	1.00	11.68	C	C
  ATOM	10146	SG	CYS	I	439	24.046	−5.015	−30.795	1.00	12.89	C	S
  ATOM	10147	C	CYS	I	439	26.437	−4.411	−32.159	1.00	10.95	C	C
  ATOM	10148	O	CYS	I	439	25.714	−4.935	−33.007	1.00	10.77	C	O
  ATOM	10149	N	ASP	I	440	27.617	−4.909	−31.802	1.00	10.41	C	N
  ATOM	10150	CA	ASP	I	440	28.240	−6.017	−32.518	1.00	10.06	C	C
  ATOM	10151	CB	ASP	I	440	29.514	−5.548	−33.224	1.00	10.85	C	C
  ATOM	10152	CG	ASP	I	440	29.336	−5.417	−34.724	1.00	13.11	C	C
  ATOM	10153	OD1	ASP	I	440	29.376	−6.453	−35.422	1.00	14.97	C	O
  ATOM	10154	OD2	ASP	I	440	29.192	−4.275	−35.209	1.00	15.27	C	O
  ATOM	10155	C	ASP	I	440	28.566	−7.175	−31.578	1.00	9.01	C	C
  ATOM	10156	O	ASP	I	440	28.479	−7.040	−30.358	1.00	9.09	C	O
  ATOM	10157	N	TYR	I	441	29.027	−8.280	−32.159	1.00	7.92	C	N
  ATOM	10158	CA	TYR	I	441	29.448	−9.461	−31.403	1.00	7.24	C	C
  ATOM	10159	CB	TYR	I	441	28.448	−10.605	−31.610	1.00	7.04	C	C
  ATOM	10160	CG	TYR	I	441	28.862	−11.916	−30.979	1.00	6.77	C	C
  ATOM	10161	CD1	TYR	I	441	28.439	−12.256	−29.701	1.00	7.41	C	C
  ATOM	10162	CE1	TYR	I	441	28.805	−13.460	−29.122	1.00	6.79	C	C
  ATOM	10163	CZ	TYR	I	441	29.529	−14.381	−29.855	1.00	6.49	C	C
  ATOM	10164	OH	TYR	I	441	29.907	−15.573	−29.277	1.00	5.09	C	O
  ATOM	10165	CE2	TYR	I	441	29.946	−14.076	−31.134	1.00	7.52	C	C
  ATOM	10166	CD2	TYR	I	441	29.600	−12.853	−31.694	1.00	7.12	C	C
  ATOM	10167	C	TYR	I	441	30.833	−9.902	−31.872	1.00	6.89	C	C
  ATOM	10168	O	TYR	I	441	31.150	−9.809	−33.058	1.00	7.12	C	O
  ATOM	10169	N	VAL	I	442	31.664	−10.363	−30.944	1.00	6.73	C	N
  ATOM	10170	CA	VAL	I	442	32.959	−10.941	−31.301	1.00	6.78	C	C
  ATOM	10171	CB	VAL	I	442	34.133	−10.008	−30.925	1.00	6.51	C	C
  ATOM	10172	CG1	VAL	I	442	34.206	−8.830	−31.879	1.00	7.38	C	C
  ATOM	10173	CG2	VAL	I	442	34.007	−9.530	−29.488	1.00	6.00	C	C
  ATOM	10174	C	VAL	I	442	33.142	−12.285	−30.609	1.00	7.13	C	C
  ATOM	10175	O	VAL	I	442	32.307	−12.689	−29.800	1.00	7.77	C	O
  ATOM	10176	N	SER	I	443	34.241	−12.970	−30.908	1.00	7.12	C	N
  ATOM	10177	CA	SER	I	443	34.476	−14.283	−30.321	1.00	7.64	C	C
  ATOM	10178	CB	SER	I	443	33.940	−15.391	−31.233	1.00	7.83	C	C
  ATOM	10179	OG	SER	I	443	34.994	−16.091	−31.870	1.00	7.99	C	O
  ATOM	10180	C	SER	I	443	35.932	−14.541	−29.940	1.00	8.16	C	C
  ATOM	10181	O	SER	I	443	36.841	−13.847	−30.399	1.00	8.69	C	O
  ATOM	10182	N	ASN	I	444	36.135	−15.517	−29.058	1.00	8.73	C	N
  ATOM	10183	CA	ASN	I	444	37.473	−15.972	−28.692	1.00	9.50	C	C
  ATOM	10184	CB	ASN	I	444	37.408	−16.989	−27.546	1.00	9.65	C	C
  ATOM	10185	CG	ASN	I	444	36.105	−16.916	−26.772	1.00	10.64	C	C
  ATOM	10186	OD1	ASN	I	444	35.530	−15.839	−26.602	1.00	12.28	C	O
  ATOM	10187	ND2	ASN	I	444	35.617	−18.069	−26.325	1.00	11.75	C	N
  ATOM	10188	C	ASN	I	444	38.240	−16.558	−29.877	1.00	10.24	C	C
  ATOM	10189	O	ASN	I	444	37.657	−17.206	−30.748	1.00	9.89	C	O
  ATOM	10190	N	LYS	I	445	39.565	−16.467	−29.809	1.00	11.63	C	N
  ATOM	10191	CA	LYS	I	445	40.394	−16.179	−30.979	1.00	13.07	C	C
  ATOM	10192	CB	LYS	I	445	40.843	−17.470	−31.664	1.00	13.70	C	C
  ATOM	10193	CG	LYS	I	445	41.782	−17.255	−32.848	1.00	15.80	C	C
  ATOM	10194	CD	LYS	I	445	42.771	−16.114	−32.613	1.00	18.31	C	C
  ATOM	10195	CE	LYS	I	445	42.855	−15.717	−31.146	1.00	19.03	C	C
  ATOM	10196	NZ	LYS	I	445	43.703	−16.652	−30.355	1.00	20.02	C	N
  ATOM	10197	C	LYS	I	445	39.701	−15.268	−31.980	1.00	12.96	C	C
  ATOM	10198	O	LYS	I	445	38.486	−15.336	−32.159	1.00	13.24	C	O
  ATOM	10199	N	GLY	I	446	40.491	−14.448	−32.664	1.00	13.08	C	N
  ATOM	10200	CA	GLY	I	446	40.131	−13.057	−32.889	1.00	12.42	C	C
  ATOM	10201	C	GLY	I	446	40.305	−12.233	−31.631	1.00	11.83	C	C
  ATOM	10202	O	GLY	I	446	41.402	−11.756	−31.342	1.00	12.44	C	O
  ATOM	10203	N	VAL	I	447	39.264	−12.192	−30.808	1.00	10.63	C	N
  ATOM	10204	CA	VAL	I	447	39.157	−11.162	−29.785	1.00	10.01	C	C
  ATOM	10205	CB	VAL	I	447	37.758	−10.516	−29.764	1.00	9.97	C	C
  ATOM	10206	CG1	VAL	I	447	37.778	−9.225	−28.957	1.00	10.51	C	C
  ATOM	10207	CG2	VAL	I	447	37.287	−10.244	−31.180	1.00	10.50	C	C
  ATOM	10208	C	VAL	I	447	39.548	−11.648	−28.390	1.00	9.53	C	C
  ATOM	10209	O	VAL	I	447	39.184	−12.747	−27.967	1.00	9.61	C	O
  ATOM	10210	N	ASP	I	448	40.211	−10.766	−27.652	1.00	9.16	C	N
  ATOM	10211	CA	ASP	I	448	40.803	−11.093	−26.362	1.00	8.75	C	C
  ATOM	10212	CB	ASP	I	448	42.325	−11.159	−26.502	1.00	9.22	C	C
  ATOM	10213	CG	ASP	I	448	42.975	−12.024	−25.443	1.00	11.44	C	C
  ATOM	10214	OD1	ASP	I	448	42.372	−12.204	−24.365	1.00	13.83	C	O
  ATOM	10215	OD2	ASP	I	448	44.119	−12.472	−25.665	1.00	14.13	C	O
  ATOM	10216	C	ASP	I	448	40.427	−9.976	−25.398	1.00	8.18	C	C
  ATOM	10217	O	ASP	I	448	40.203	−10.209	−24.211	1.00	8.06	C	O
  ATOM	10218	N	THR	I	449	40.201	−8.794	−25.964	1.00	7.63	C	N
  ATOM	10219	CA	THR	I	449	39.894	−7.592	−25.197	1.00	6.80	C	C
  ATOM	10220	CB	THR	I	449	41.165	−6.750	−24.940	1.00	6.89	C	C
  ATOM	10221	OG1	THR	I	449	41.805	−7.196	−23.738	1.00	6.16	C	O
  ATOM	10222	CG2	THR	I	449	40.815	−5.275	−24.804	1.00	7.55	C	C
  ATOM	10223	C	THR	I	449	38.898	−6.751	−25.987	1.00	6.53	C	C
  ATOM	10224	O	THR	I	449	38.949	−6.708	−27.216	1.00	6.59	C	O
  ATOM	10225	N	VAL	I	450	37.947	−6.147	−25.288	1.00	6.07	C	N
  ATOM	10226	CA	VAL	I	450	37.318	−4.934	−25.781	1.00	6.02	C	C
  ATOM	10227	CB	VAL	I	450	35.839	−5.158	−26.121	1.00	5.61	C	C
  ATOM	10228	CG1	VAL	I	450	35.697	−6.278	−27.136	1.00	5.32	C	C
  ATOM	10229	CG2	VAL	I		450	35.047	−5.460	−24.860	1.00	5.55	C	C
  ATOM	10230	C	VAL	I	450	37.427	−3.837	−24.743	1.00	6.37	C	C
  ATOM	10231	O	VAL	I	450	37.359	−4.097	−23.542	1.00	6.54	C	O
  ATOM	10232	N	SER	I	451	37.704	−2.626	−25.207	1.00	6.41	C	N
  ATOM	10233	CA	SER	I	451	37.571	−1.451	−24.366	1.00	6.70	C	C
  ATOM	10234	CB	SER	I	451	38.845	−0.607	−24.422	1.00	7.13	C	C
  ATOM	10235	OG	SER	I	451	39.573	−0.864	−25.610	1.00	9.26	C	O
  ATOM	10236	C	SER	I	451	36.373	−0.626	−24.802	1.00	6.47	C	C
  ATOM	10237	O	SER	I	451	36.100	−0.493	−25.994	1.00	6.54	C	O
  ATOM	10238	N	VAL	I	452	35.577	−0.203	−23.830	1.00	6.56	C	N
  ATOM	10239	CA	VAL	I	452	34.627	0.872	−24.050	1.00	6.31	C	C
  ATOM	10240	CB	VAL	I	452	33.205	0.448	−23.647	1.00	5.74	C	C
  ATOM	10241	CG1	VAL	I	452	32.189	1.471	−24.130	1.00	5.06	C	C
  ATOM	10242	CG2	VAL	I	452	32.891	−0.929	−24.212	1.00	5.56	C	C
  ATOM	10243	C	VAL	I	452	35.056	2.087	−23.242	1.00	6.60	C	C
  ATOM	10244	O	VAL	I	452	35.499	1.950	−22.102	1.00	7.04	C	O
  ATOM	10245	N	GLY	I	453	35.141	3.234	−23.907	1.00	6.54	C	N
  ATOM	10246	CA	GLY	I	453	35.790	4.395	−23.314	1.00	6.43	C	C
  ATOM	10247	C	GLY	I	453	37.010	3.964	−22.525	1.00	6.09	C	C
  ATOM	10248	O	GLY	I	453	37.910	3.328	−23.071	1.00	5.90	C	O
  ATOM	10249	N	ASN	I	454	36.985	4.188	−21.216	1.00	6.02	C	N
  ATOM	10250	CA	ASN	I	454	38.156	3.904	−20.396	1.00	6.39	C	C
  ATOM	10251	CB	ASN	I	454	38.491	5.088	−19.491	1.00	6.81	C	C
  ATOM	10252	CG	ASN	I	454	39.518	6.009	−20.108	1.00	8.99	C	C
  ATOM	10253	OD1	ASN	I	454	40.718	5.817	−19.912	1.00	11.67	C	O
  ATOM	10254	ND2	ASN	I	454	39.073	6.836	−21.048	1.00	10.25	C	N
  ATOM	10255	C	ASN	I	454	38.053	2.617	−19.588	1.00	6.15	C	C
  ATOM	10256	O	ASN	I	454	39.041	2.154	−19.016	1.00	6.47	C	O
  ATOM	10257	N	THR	I	455	36.888	1.983	−19.635	1.00	5.40	C	N
  ATOM	10258	CA	THR	I	455	36.730	0.659	−19.057	1.00	4.53	C	C
  ATOM	10259	CB	THR	I	455	35.251	0.352	−18.737	1.00	4.70	C	C
  ATOM	10260	OG1	THR	I	455	34.662	1.471	−18.063	1.00	5.28	C	O
  ATOM	10261	CG2	THR	I	455	35.141	−0.878	−17.845	1.00	5.57	C	C
  ATOM	10262	C	THR	I	455	37.296	−0.399	−19.999	1.00	4.01	C	C
  ATOM	10263	O	THR	I	455	37.333	−0.204	−21.216	1.00	3.78	C	O
  ATOM	10264	N	LEU	I	456	37.885	−1.438	−19.414	1.00	3.87	C	N
  ATOM	10265	CA	LEU	I	456	38.439	−2.542	−20.189	1.00	4.05	C	C
  ATOM	10266	CB	LEU	I	456	39.946	−2.660	−19.955	1.00	3.95	C	C
  ATOM	10267	CG	LEU	I	456	40.690	−3.636	−20.868	1.00	3.76	C	C
  ATOM	10268	CD1	LEU	I	456	40.594	−3.192	−22.319	1.00	5.35	C	C
  ATOM	10269	CD2	LEU	I	456	42.142	−3.770	−20.440	1.00	4.10	C	C
  ATOM	10270	C	LEU	I	456	37.755	−3.858	−19.845	1.00	4.47	C	C
  ATOM	10271	O	LEU	I	456	37.769	−4.293	−18.694	1.00	4.94	C	O
  ATOM	10272	N	TYR	I	457	37.248	−4.534	−20.869	1.00	4.59	C	N
  ATOM	10273	CA	TYR	I	457	36.626	−5.839	−20.695	1.00	4.60	C	C
  ATOM	10274	CB	TYR	I	457	35.248	−5.861	−21.363	1.00	4.71	C	C
  ATOM	10275	CG	TYR	I	457	34.244	−4.912	−20.739	1.00	5.62	C	C
  ATOM	10276	CD1	TYR	I	457	34.230	−3.563	−21.074	1.00	7.09	C	C
  ATOM	10277	CE1	TYR	I	457	33.316	−2.697	−20.510	1.00	8.22	C	C
  ATOM	10278	CZ	TYR	I	457	32.408	−3.173	−19.588	1.00	8.06	C	C
  ATOM	10279	OH	TYR	I	457	31.469	−2.318	−19.059	1.00	8.80	C	O
  ATOM	10280	CE2	TYR	I	457	32.381	−4.513	−19.262	1.00	7.18	C	C
  ATOM	10281	CD2	TYR	I	457	33.302	−5.371	−19.827	1.00	6.66	C	C
  ATOM	10282	C	TYR	I	457	37.513	−6.932	−21.285	1.00	4.46	C	C
  ATOM	10283	O	TYR	I	457	38.049	−6.780	−22.383	1.00	4.92	C	O
  ATOM	10284	N	TYR	I	458	37.706	−8.009	−20.529	1.00	3.90	C	N
  ATOM	10285	CA	TYR	I	458	38.520	−9.138	−20.980	1.00	3.26	C	C
  ATOM	10286	CB	TYR	I	458	39.407	−9.632	−19.832	1.00	3.16	C	C
  ATOM	10287	CG	TYR	I	458	40.399	−8.610	−19.320	1.00	3.29	C	C
  ATOM	10288	CD1	TYR	I	458	40.076	−7.762	−18.269	1.00	3.93	C	C
  ATOM	10289	CE1	TYR	I	458	40.993	−6.848	−17.782	1.00	4.90	C	C
  ATOM	10290	CZ	TYR	I	458	42.245	−6.766	−18.354	1.00	5.12	C	C
  ATOM	10291	OH	TYR	I	458	43.156	−5.850	−17.881	1.00	5.42	C	O
  ATOM	10292	CE2	TYR	I	458	42.590	−7.599	−19.395	1.00	4.72	C	C
  ATOM	10293	CD2	TYR	I	458	41.677	−8.528	−19.858	1.00	3.89	C	C
  ATOM	10294	C	TYR	I	458	37.638	−10.293	−21.464	1.00	3.04	C	C
  ATOM	10295	O	TYR	I	458	36.897	−10.869	−20.672	1.00	3.37	C	O
  ATOM	10296	N	VAL	I	459	37.857	−10.755	−22.696	1.00	2.71	C	N
  ATOM	10297	CA	VAL	I	459	36.818	−11.487	−23.441	1.00	2.61	C	C
  ATOM	10298	CB	VAL	I	459	36.856	−11.172	−24.940	1.00	2.22	C	C
  ATOM	10299	CG1	VAL	I	459	35.936	−12.119	−25.698	1.00	2.62	C	C
  ATOM	10300	CG2	VAL	I	459	36.459	−9.728	−25.187	1.00	2.61	C	C
  ATOM	10301	C	VAL	I	459	36.847	−13.006	−23.279	1.00	3.03	C	C
  ATOM	10302	O	VAL	I	459	37.324	−13.520	−22.267	1.00	3.21	C	O
  ATOM	10303	N	ASN	I	460	36.301	−13.724	−24.263	1.00	106.93	C	N
  ATOM	10304	CA	ASN	I	460	36.733	−15.100	−24.460	1.00	95.54	C	C
  ATOM	10305	CB	ASN	I	460	37.469	−15.533	−23.198	1.00	20.00	C	C
  ATOM	10306	CG	ASN	I	460	38.132	−16.862	−23.352	1.00	20.00	C	C
  ATOM	10307	OD1	ASN	I	460	38.781	−17.118	−24.365	1.00	20.00	C	O
  ATOM	10308	ND2	ASN	I	460	37.824	−17.783	−22.448	1.00	20.00	C	N
  ATOM	10309	C	ASN	I	460	35.684	−16.173	−24.797	1.00	99.41	C	C
  ATOM	10310	O	ASN	I	460	35.555	−17.141	−24.047	1.00	108.91	C	O
  ATOM	10311	N	LYS	I	461	35.174	−16.182	−26.023	1.00	97.04	C	N
  ATOM	10312	CA	LYS	I	461	34.426	−17.350	−26.495	1.00	105.93	C	C
  ATOM	10313	CB	LYS	I	461	33.128	−17.516	−25.700	1.00	20.00	C	C
  ATOM	10314	CG	LYS	I	461	33.324	−18.050	−24.284	1.00	20.00	C	C
  ATOM	10315	CD	LYS	I	461	32.012	−18.071	−23.510	1.00	20.00	C	C
  ATOM	10316	CE	LYS	I	461	32.154	−18.798	−22.179	1.00	20.00	C	C
  ATOM	10317	NZ	LYS	I	461	30.869	−19.408	−21.736	1.00	20.00	C	N
  ATOM	10318	C	LYS	I	461	34.141	−17.231	−27.987	1.00	102.28	C	C
  ATOM	10319	O	LYS	I	461	34.601	−16.289	−28.627	1.00	105.02	C	O
  ATOM	10320	N	GLN	I	462	33.377	−18.164	−28.545	1.00	96.68	C	N
  ATOM	10321	CA	GLN	I	462	32.944	−18.040	−29.939	1.00	105.71	C	C
  ATOM	10322	CB	GLN	I	462	33.693	−19.032	−30.836	1.00	20.00	C	C
  ATOM	10323	CG	GLN	I	462	35.184	−18.748	−30.976	1.00	20.00	C	C
  ATOM	10324	CD	GLN	I	462	35.922	−19.829	−31.741	1.00	20.00	C	C
  ATOM	10325	OE1	GLN	I	462	35.456	−20.965	−31.841	1.00	20.00	C	O
  ATOM	10326	NE2	GLN	I	462	37.071	−19.475	−32.303	1.00	20.00	C	N
  ATOM	10327	C	GLN	I	462	31.440	−18.235	−30.082	1.00	101.50	C	C
  ATOM	10328	O	GLN	I	462	30.881	−19.193	−29.553	1.00	105.94	C	O
  ATOM	10329	N	GLU	I	463	30.787	−17.335	−30.809	1.00	98.92	C	N
  ATOM	10330	CA	GLU	I	463	29.339	−17.413	−30.975	1.00	108.59	C	C
  ATOM	10331	CB	GLU	I	463	28.684	−16.055	−30.712	1.00	20.00	C	C
  ATOM	10332	CG	GLU	I	463	28.617	−15.668	−29.238	1.00	20.00	C	C
  ATOM	10333	CD	GLU	I	463	28.032	−14.283	−29.019	1.00	20.00	C	C
  ATOM	10334	OE1	GLU	I	463	27.535	−13.682	−29.995	1.00	20.00	C	O
  ATOM	10335	OE2	GLU	I	463	27.975	−13.842	−27.851	1.00	20.00	C	O
  ATOM	10336	C	GLU	I	463	28.950	−17.934	−32.353	1.00	116.39	C	C
  ATOM	10337	O	GLU	I	463	29.396	−17.411	−33.375	1.00	118.70	C	O
  ATOM	10338	N	GLY	I	464	28.103	−18.957	−32.372	1.00	127.70	C	N
  ATOM	10339	CA	GLY	I	464	27.598	−19.512	−33.621	1.00	143.17	C	C
  ATOM	10340	C	GLY	I	464	26.466	−18.687	−34.200	1.00	149.77	C	C
  ATOM	10341	O	GLY	I	464	25.945	−17.784	−33.545	1.00	155.06	C	O
  ATOM	10342	N	LYS	I	465	26.088	−18.997	−35.435	1.00	153.73	C	N
  ATOM	10343	CA	LYS	I	465	25.034	−18.261	−36.124	1.00	153.69	C	C
  ATOM	10344	CB	LYS	I	465	23.750	−18.259	−35.293	1.00	20.00	C	C
  ATOM	10345	CG	LYS	I	465	23.099	−19.626	−35.151	1.00	20.00	C	C
  ATOM	10346	CD	LYS	I	465	21.848	−19.555	−34.292	1.00	20.00	C	C
  ATOM	10347	CE	LYS	I	465	21.188	−20.919	−34.164	1.00	20.00	C	C
  ATOM	10348	NZ	LYS	I	465	19.972	−20.869	−33.307	1.00	20.00	C	N
  ATOM	10349	C	LYS	I	465	25.466	−16.831	−36.426	1.00	155.37	C	C
  ATOM	10350	O	LYS	I	465	25.158	−16.292	−37.489	1.00	155.20	C	O
  ATOM	10351	N	GLU	I	472	20.477	−14.304	−43.583	1.00	145.47	C	N
  ATOM	10352	CA	GLU	I	472	19.435	−13.563	−44.284	1.00	151.12	C	C
  ATOM	10353	CB	GLU	I	472	18.367	−14.521	−44.821	1.00	20.00	C	C
  ATOM	10354	CG	GLU	I	472	18.856	−15.453	−45.922	1.00	20.00	C	C
  ATOM	10355	CD	GLU	I	472	17.778	−16.409	−46.402	1.00	20.00	C	C
  ATOM	10356	OE1	GLU	I	472	16.723	−16.504	−45.739	1.00	20.00	C	O
  ATOM	10357	OE2	GLU	I	472	17.996	−17.083	−47.430	1.00	20.00	C	O
  ATOM	10358	C	GLU	I	472	18.796	−12.521	−43.369	1.00	153.35	C	C
  ATOM	10359	O	GLU	I	472	18.205	−12.866	−42.345	1.00	159.41	C	O
  ATOM	10360	N	PRO	I	473	18.943	−11.236	−43.722	1.00	150.51	C	N
  ATOM	10361	CA	PRO	I	473	18.346	−10.158	−42.958	1.00	141.97	C	C
  ATOM	10362	CB	PRO	I	473	19.542	−9.243	−42.691	1.00	20.00	C	C
  ATOM	10363	CG	PRO	I	473	20.496	−9.502	−43.863	1.00	20.00	C	C
  ATOM	10364	CD	PRO	I	473	20.007	−10.730	−44.602	1.00	20.00	C	C
  ATOM	10365	C	PRO	I	473	17.331	−9.429	−43.824	1.00	135.14	C	C
  ATOM	10366	O	PRO	I	473	17.408	−9.503	−45.051	1.00	144.93	C	O
  ATOM	10367	N	ILE	I	474	16.371	−8.757	−43.197	1.00	118.07	C	N
  ATOM	10368	CA	ILE	I	474	15.320	−8.071	−43.939	1.00	105.14	C	C
  ATOM	10369	CB	ILE	I	474	14.440	−9.067	−44.737	1.00	20.00	C	C
  ATOM	10370	CG1	ILE	I	474	15.255	−9.730	−45.856	1.00	20.00	C	C
  ATOM	10371	CD1	ILE	I	474	14.525	−10.842	−46.588	1.00	20.00	C	C
  ATOM	10372	CG2	ILE	I	474	13.224	−8.354	−45.317	1.00	20.00	C	C
  ATOM	10373	C	ILE	I	474	14.436	−7.226	−43.022	1.00	104.75	C	C
  ATOM	10374	O	ILE	I	474	13.471	−7.725	−42.443	1.00	111.83	C	O
  ATOM	10375	N	ILE	I	475	14.746	−5.934	−42.932	1.00	94.65	C	N
  ATOM	10376	CA	ILE	I	475	14.105	−5.051	−41.957	1.00	79.88	C	C
  ATOM	10377	CB	ILE	I	475	15.105	−4.568	−40.885	1.00	20.00	C	C
  ATOM	10378	CG1	ILE	I	475	15.576	−5.737	−40.014	1.00	20.00	C	C
  ATOM	10379	CD1	ILE	I	475	16.791	−5.417	−39.163	1.00	20.00	C	C
  ATOM	10380	CG2	ILE	I	475	14.493	−3.458	−40.043	1.00	20.00	C	C
  ATOM	10381	C	ILE	I	475	13.459	−3.835	−42.617	1.00	79.52	C	C
  ATOM	10382	O	ILE	I	475	14.150	−2.913	−43.054	1.00	82.70	C	O
  ATOM	10383	N	ASN	I	476	12.133	−3.791	−42.590	1.00	69.64	C	N
  ATOM	10384	CA	ASN	I	476	11.404	−2.621	−43.048	1.00	68.88	C	C
  ATOM	10385	CB	ASN	I	476	9.979	−3.002	−43.442	1.00	20.00	C	C
  ATOM	10386	CG	ASN	I	476	9.939	−3.881	−44.672	1.00	20.00	C	C
  ATOM	10387	OD1	ASN	I	476	10.854	−3.856	−45.496	1.00	20.00	C	O
  ATOM	10388	ND2	ASN	I	476	8.918	−4.722	−44.762	1.00	20.00	C	N
  ATOM	10389	C	ASN	I	476	11.401	−1.512	−42.004	1.00	67.13	C	C
  ATOM	10390	O	ASN	I	476	11.491	−1.781	−40.806	1.00	73.10	C	O
  ATOM	10391	N	PHE	I	477	11.492	−0.273	−42.474	1.00	64.95	C	N
  ATOM	10392	CA	PHE	I	477	11.535	0.883	−41.585	1.00	68.13	C	C
  ATOM	10393	CB	PHE	I	477	12.064	2.118	−42.327	1.00	20.00	C	C
  ATOM	10394	CG	PHE	I	477	13.494	1.995	−42.778	1.00	20.00	C	C
  ATOM	10395	CD1	PHE	I	477	14.532	2.409	−41.955	1.00	20.00	C	C
  ATOM	10396	CE1	PHE	I	477	15.842	2.359	−42.391	1.00	20.00	C	C
  ATOM	10397	CZ	PHE	I	477	16.127	1.910	−43.665	1.00	20.00	C	C
  ATOM	10398	CE2	PHE	I	477	15.100	1.529	−44.506	1.00	20.00	C	C
  ATOM	10399	CD2	PHE	I	477	13.791	1.596	−44.070	1.00	20.00	C	C
  ATOM	10400	C	PHE	I	477	10.167	1.186	−40.968	1.00	65.57	C	C
  ATOM	10401	O	PHE	I	477	10.033	2.109	−40.165	1.00	49.83	C	O
  ATOM	10402	N	TYR	I	478	9.136	0.485	−41.432	1.00	51.97	C	N
  ATOM	10403	CA	TYR	I	478	7.811	0.580	−40.824	1.00	52.01	C	C
  ATOM	10404	CB	TYR	I	478	6.729	0.140	−41.815	1.00	20.00	C	C
  ATOM	10405	CG	TYR	I	478	6.638	1.012	−43.045	1.00	20.00	C	C
  ATOM	10406	CD1	TYR	I	478	5.883	2.179	−43.040	1.00	20.00	C	C
  ATOM	10407	CE1	TYR	I	478	5.824	2.997	−44.155	1.00	20.00	C	C
  ATOM	10408	CZ	TYR	I	478	6.512	2.642	−45.300	1.00	20.00	C	C
  ATOM	10409	OH	TYR	I	478	6.454	3.447	−46.414	1.00	20.00	C	O
  ATOM	10410	CE2	TYR	I	478	7.260	1.484	−45.333	1.00	20.00	C	C
  ATOM	10411	CD2	TYR	I	478	7.319	0.677	−44.210	1.00	20.00	C	C
  ATOM	10412	C	TYR	I	478	7.745	−0.269	−39.556	1.00	66.63	C	C
  ATOM	10413	O	TYR	I	478	6.674	−0.470	−38.983	1.00	63.45	C	O
  ATOM	10414	N	ASP	I	479	8.898	−0.790	−39.146	1.00	65.34	C	N
  ATOM	10415	CA	ASP	I	479	9.013	−1.509	−37.886	1.00	65.32	C	C
  ATOM	10416	CB	ASP	I	479	9.879	−2.758	−38.061	1.00	20.00	C	C
  ATOM	10417	CG	ASP	I	479	9.210	−3.815	−38.916	1.00	20.00	C	C
  ATOM	10418	OD1	ASP	I	479	7.967	−3.791	−39.028	1.00	20.00	C	O
  ATOM	10419	OD2	ASP	I	479	9.920	−4.701	−39.436	1.00	20.00	C	O
  ATOM	10420	C	ASP	I	479	9.590	−0.614	−36.796	1.00	64.83	C	C
  ATOM	10421	O	ASP	I	479	9.572	−0.976	−35.620	1.00	60.42	C	O
  ATOM	10422	N	PRO	I	480	10.076	0.579	−37.181	1.00	47.60	C	N
  ATOM	10423	CA	PRO	I	480	10.722	1.488	−36.253	1.00	46.52	C	C
  ATOM	10424	CB	PRO	I	480	11.789	2.143	−37.124	1.00	20.00	C	C
  ATOM	10425	CG	PRO	I	480	11.140	2.219	−38.487	1.00	20.00	C	C
  ATOM	10426	CD	PRO	I	480	10.043	1.155	−38.536	1.00	20.00	C	C
  ATOM	10427	C	PRO	I	480	9.736	2.550	−35.806	1.00	52.36	C	C
  ATOM	10428	O	PRO	I	480	9.629	3.601	−36.438	1.00	64.15	C	O
  ATOM	10429	N	LEU	I	481	8.945	2.229	−34.792	1.00	62.90	C	N
  ATOM	10430	CA	LEU	I	481	8.005	3.187	−34.233	1.00	54.24	C	C
  ATOM	10431	CB	LEU	I	481	6.576	2.656	−34.340	1.00	20.00	C	C
  ATOM	10432	CG	LEU	I	481	6.056	2.404	−35.756	1.00	20.00	C	C
  ATOM	10433	CD1	LEU	I	481	4.735	1.662	−35.704	1.00	20.00	C	C
  ATOM	10434	CD2	LEU	I	481	5.911	3.711	−36.524	1.00	20.00	C	C
  ATOM	10435	C	LEU	I	481	8.346	3.496	−32.783	1.00	59.81	C	C
  ATOM	10436	O	LEU	I	481	9.346	3.015	−32.250	1.00	64.98	C	O
  ATOM	10437	N	VAL	I	482	7.562	4.375	−32.176	1.00	59.66	C	N
  ATOM	10438	CA	VAL	I	482	7.706	4.645	−30.761	1.00	49.67	C	C
  ATOM	10439	CB	VAL	I	482	7.767	6.146	−30.484	1.00	20.00	C	C
  ATOM	10440	CG1	VAL	I	482	8.060	6.388	−29.015	1.00	20.00	C	C
  ATOM	10441	CG2	VAL	I	482	8.826	6.795	−31.358	1.00	20.00	C	C
  ATOM	10442	C	VAL	I	482	6.550	4.037	−29.987	1.00	53.03	C	C
  ATOM	10443	O	VAL	I	482	5.423	3.998	−30.476	1.00	46.27	C	O
  ATOM	10444	N	PHE	I	483	6.864	3.441	−28.842	1.00	61.61	C	N
  ATOM	10445	CA	PHE	I	483	5.847	2.831	−27.994	1.00	65.03	C	C
  ATOM	10446	CB	PHE	I	483	6.218	1.380	−27.662	1.00	20.00	C	C
  ATOM	10447	CG	PHE	I	483	6.212	0.463	−28.857	1.00	20.00	C	C
  ATOM	10448	CD1	PHE	I	483	5.036	−0.124	−29.292	1.00	20.00	C	C
  ATOM	10449	CE1	PHE	I	483	5.028	−0.963	−30.390	1.00	20.00	C	C
  ATOM	10450	CZ	PHE	I	483	6.201	−1.222	−31.068	1.00	20.00	C	C
  ATOM	10451	CE2	PHE	I	483	7.379	−0.653	−30.639	1.00	20.00	C	C
  ATOM	10452	CD2	PHE	I	483	7.382	0.185	−29.540	1.00	20.00	C	C
  ATOM	10453	C	PHE	I	483	5.627	3.653	−26.723	1.00	71.00	C	C
  ATOM	10454	O	PHE	I	483	5.934	3.199	−25.620	1.00	100.44	C	O
  ATOM	10455	N	PRO	I	484	5.255	4.928	−26.903	1.00	54.44	C	N
  ATOM	10456	CA	PRO	I	484	5.000	5.815	−25.781	1.00	47.46	C	C
  ATOM	10457	CB	PRO	I	484	6.136	6.828	−25.903	1.00	20.00	C	C
  ATOM	10458	CG	PRO	I	484	6.468	6.851	−27.406	1.00	20.00	C	C
  ATOM	10459	CD	PRO	I	484	5.760	5.686	−28.058	1.00	20.00	C	C
  ATOM	10460	C	PRO	I	484	3.661	6.533	−25.944	1.00	41.56	C	C
  ATOM	10461	O	PRO	I	484	3.430	7.190	−26.959	1.00	46.53	C	O
  ATOM	10462	N	SER	I	485	2.779	6.380	−24.964	1.00	46.30	C	N
  ATOM	10463	CA	SER	I	485	1.436	6.938	−25.048	1.00	49.30	C	C
  ATOM	10464	CB	SER	I	485	0.892	7.220	−23.649	1.00	20.00	C	C
  ATOM	10465	OG	SER	I	485	1.684	8.188	−22.983	1.00	20.00	C	O
  ATOM	10466	C	SER	I	485	1.380	8.204	−25.901	1.00	41.24	C	C
  ATOM	10467	O	SER	I	485	0.643	8.262	−26.883	1.00	46.93	C	O
  ATOM	10468	N	ASP	I	486	2.103	9.238	−25.482	1.00	49.48	C	N
  ATOM	10469	CA	ASP	I	486	2.085	10.518	−26.185	1.00	37.44	C	C
  ATOM	10470	CB	ASP	I	486	3.029	11.514	−25.511	1.00	20.00	C	C
  ATOM	10471	CG	ASP	I	486	2.509	11.993	−24.173	1.00	20.00	C	C
  ATOM	10472	OD1	ASP	I	486	1.314	11.773	−23.887	1.00	20.00	C	O
  ATOM	10473	OD2	ASP	I	486	3.299	12.566	−23.395	1.00	20.00	C	O
  ATOM	10474	C	ASP	I	486	2.456	10.359	−27.656	1.00	45.66	C	C
  ATOM	10475	O	ASP	I	486	1.752	10.848	−28.539	1.00	39.86	C	O
  ATOM	10476	N	GLU	I	487	3.559	9.665	−27.914	1.00	49.20	C	N
  ATOM	10477	CA	GLU	I	487	4.006	9.422	−29.280	1.00	45.70	C	C
  ATOM	10478	CB	GLU	I	487	5.346	8.684	−29.288	1.00	20.00	C	C
  ATOM	10479	CG	GLU	I	487	6.491	9.481	−28.685	1.00	20.00	C	C
  ATOM	10480	CD	GLU	I	487	7.766	8.669	−28.551	1.00	20.00	C	C
  ATOM	10481	OE1	GLU	I	487	7.722	7.447	−28.804	1.00	20.00	C	O
  ATOM	10482	OE2	GLU	I	487	8.794	9.238	−28.122	1.00	20.00	C	O
  ATOM	10483	C	GLU	I	487	2.966	8.648	−30.085	1.00	41.48	C	C
  ATOM	10484	O	GLU	I	487	2.656	9.011	−31.219	1.00	48.92	C	O
  ATOM	10485	N	PHE	I	488	2.402	7.606	−29.483	1.00	42.16	C	N
  ATOM	10486	CA	PHE	I	488	1.397	6.789	−30.155	1.00	39.33	C	C
  ATOM	10487	CB	PHE	I	488	0.968	5.623	−29.268	1.00	20.00	C	C
  ATOM	10488	CG	PHE	I	488	2.059	4.633	−29.005	1.00	20.00	C	C
  ATOM	10489	CD1	PHE	I	488	2.403	3.694	−29.958	1.00	20.00	C	C
  ATOM	10490	CE1	PHE	I	488	3.409	2.779	−29.715	1.00	20.00	C	C
  ATOM	10491	CZ	PHE	I	488	4.089	2.807	−28.517	1.00	20.00	C	C
  ATOM	10492	CE2	PHE	I	488	3.752	3.737	−27.560	1.00	20.00	C	C
  ATOM	10493	CD2	PHE	I	488	2.752	4.652	−27.810	1.00	20.00	C	C
  ATOM	10494	C	PHE	I	488	0.182	7.618	−30.540	1.00	43.06	C	C
  ATOM	10495	O	PHE	I	488	−0.328	7.508	−31.654	1.00	61.71	C	O
  ATOM	10496	N	ASP	I	489	−0.261	8.471	−29.624	1.00	41.95	C	N
  ATOM	10497	CA	ASP	I	489	−1.454	9.273	−29.851	1.00	42.75	C	C
  ATOM	10498	CB	ASP	I	489	−1.837	10.023	−28.581	1.00	20.00	C	C
  ATOM	10499	CG	ASP	I	489	−2.352	9.102	−27.504	1.00	20.00	C	C
  ATOM	10500	OD1	ASP	I	489	−2.808	7.989	−27.848	1.00	20.00	C	O
  ATOM	10501	OD2	ASP	I	489	−2.184	9.435	−26.313	1.00	20.00	C	O
  ATOM	10502	C	ASP	I	489	−1.255	10.256	−30.994	1.00	45.61	C	C
  ATOM	10503	O	ASP	I	489	−2.206	10.617	−31.689	1.00	54.39	C	O
  ATOM	10504	N	ALA	I	490	−0.020	10.714	−31.160	1.00	42.89	C	N
  ATOM	10505	CA	ALA	I	490	0.306	11.663	−32.215	1.00	38.40	C	C
  ATOM	10506	CB	ALA	I	490	1.684	12.262	−31.976	1.00	20.00	C	C
  ATOM	10507	C	ALA	I	490	0.240	10.994	−33.585	1.00	39.67	C	C
  ATOM	10508	O	ALA	I	490	−0.356	11.529	−34.521	1.00	56.80	C	O
  ATOM	10509	N	SER	I	491	0.803	9.793	−33.676	1.00	40.38	C	N
  ATOM	10510	CA	SER	I	491	0.721	8.992	−34.893	1.00	41.77	C	C
  ATOM	10511	CB	SER	I	491	1.611	7.752	−34.784	1.00	20.00	C	C
  ATOM	10512	OG	SER	I	491	1.132	6.864	−33.788	1.00	20.00	C	O
  ATOM	10513	C	SER	I	491	−0.717	8.580	−35.187	1.00	39.01	C	C
  ATOM	10514	O	SER	I	491	−1.142	8.563	−36.342	1.00	36.91	C	O
  ATOM	10515	N	ILE	I	492	−1.474	8.286	−34.135	1.00	38.11	C	N
  ATOM	10516	CA	ILE	I	492	−2.896	8.000	−34.280	1.00	41.21	C	C
  ATOM	10517	CB	ILE	I	492	−3.539	7.629	−32.938	1.00	20.00	C	C
  ATOM	10518	CG1	ILE	I	492	−2.964	6.311	−32.424	1.00	20.00	C	C
  ATOM	10519	CD1	ILE	I	492	−3.501	5.906	−31.076	1.00	20.00	C	C
  ATOM	10520	CG2	ILE	I	492	−5.050	7.533	−33.080	1.00	20.00	C	C
  ATOM	10521	C	ILE	I	492	−3.646	9.182	−34.883	1.00	39.22	C	C
  ATOM	10522	O	ILE	I	492	−4.494	9.008	−35.758	1.00	47.54	C	O
  ATOM	10523	N	SER	I	493	−3.334	10.383	−34.408	1.00	41.64	C	N
  ATOM	10524	CA	SER	I	493	−3.929	11.598	−34.952	1.00	35.15	C	C
  ATOM	10525	CB	SER	I	493	−3.483	12.820	−34.146	1.00	20.00	C	C
  ATOM	10526	OG	SER	I	493	−2.100	13.070	−34.322	1.00	20.00	C	O
  ATOM	10527	C	SER	I	493	−3.547	11.773	−36.416	1.00	47.90	C	C
  ATOM	10528	O	SER	I	493	−4.380	12.128	−37.250	1.00	50.94	C	O
  ATOM	10529	N	GLN	I	494	−2.296	11.457	−36.727	1.00	42.51	C	N
  ATOM	10530	CA	GLN	I	494	−1.784	11.587	−38.081	1.00	41.96	C	C
  ATOM	10531	CB	GLN	I	494	−0.263	11.405	−38.085	1.00	20.00	C	C
  ATOM	10532	CG	GLN	I	494	0.495	12.482	−37.308	1.00	20.00	C	C
  ATOM	10533	CD	GLN	I	494	1.989	12.210	−37.223	1.00	20.00	C	C
  ATOM	10534	OE1	GLN	I	494	2.410	11.104	−36.881	1.00	20.00	C	O
  ATOM	10535	NE2	GLN	I	494	2.790	13.248	−37.433	1.00	20.00	C	N
  ATOM	10536	C	GLN	I	494	−2.449	10.583	−39.023	1.00	33.86	C	C
  ATOM	10537	O	GLN	I	494	−2.944	10.950	−40.090	1.00	54.89	C	O
  ATOM	10538	N	VAL	I	495	−2.511	9.328	−38.594	1.00	34.99	C	N
  ATOM	10539	CA	VAL	I	495	−3.226	8.300	−39.341	1.00	38.42	C	C
  ATOM	10540	CB	VAL	I	495	−3.245	6.968	−38.576	1.00	20.00	C	C
  ATOM	10541	CG1	VAL	I	495	−4.032	5.922	−39.349	1.00	20.00	C	C
  ATOM	10542	CG2	VAL	I	495	−1.828	6.497	−38.309	1.00	20.00	C	C
  ATOM	10543	C	VAL	I	495	−4.661	8.731	−39.618	1.00	42.74	C	C
  ATOM	10544	O	VAL	I	495	−5.144	8.634	−40.747	1.00	44.00	C	O
  ATOM	10545	N	ASN	I	496	−5.314	9.268	−38.592	1.00	42.45	C	N
  ATOM	10546	CA	ASN	I	496	−6.705	9.685	−38.697	1.00	43.01	C	C
  ATOM	10547	CB	ASN	I	496	−7.232	10.134	−37.333	1.00	20.00	C	C
  ATOM	10548	CG	ASN	I	496	−7.416	8.977	−36.374	1.00	20.00	C	C
  ATOM	10549	OD1	ASN	I	496	−7.439	7.817	−36.784	1.00	20.00	C	O
  ATOM	10550	ND2	ASN	I	496	−7.495	9.283	−35.083	1.00	20.00	C	N
  ATOM	10551	C	ASN	I	496	−6.906	10.790	−39.727	1.00	43.13	C	C
  ATOM	10552	O	ASN	I	496	−7.893	10.793	−40.462	1.00	54.76	C	O
  ATOM	10553	N	GLU	I	497	−5.990	11.752	−39.744	1.00	42.08	C	N
  ATOM	10554	CA	GLU	I	497	−6.038	12.828	−40.726	1.00	43.13	C	C
  ATOM	10555	CB	GLU	I	497	−4.947	13.863	−40.443	1.00	20.00	C	C
  ATOM	10556	CG	GLU	I	497	−5.172	14.672	−39.175	1.00	20.00	C	C
  ATOM	10557	CD	GLU	I	497	−4.045	15.647	−38.896	1.00	20.00	C	C
  ATOM	10558	OE1	GLU	I	497	−3.007	15.574	−39.587	1.00	20.00	C	O
  ATOM	10559	OE2	GLU	I	497	−4.192	16.480	−37.977	1.00	20.00	C	O
  ATOM	10560	C	GLU	I	497	−5.884	12.275	−42.137	1.00	49.77	C	C
  ATOM	10561	O	GLU	I	497	−6.542	12.736	−43.071	1.00	42.88	C	O
  ATOM	10562	N	LYS	I	498	−5.051	11.249	−42.273	1.00	41.82	C	N
  ATOM	10563	CA	LYS	I	498	−4.855	10.579	−43.552	1.00	53.60	C	C
  ATOM	10564	CB	LYS	I	498	−3.676	9.609	−43.471	1.00	20.00	C	C
  ATOM	10565	CG	LYS	I	498	−2.336	10.274	−43.228	1.00	20.00	C	C
  ATOM	10566	CD	LYS	I	498	−1.193	9.356	−43.638	1.00	20.00	C	C
  ATOM	10567	CE	LYS	I	498	0.160	9.937	−43.247	1.00	20.00	C	C
  ATOM	10568	NZ	LYS	I	498	1.285	9.250	−43.942	1.00	20.00	C	N
  ATOM	10569	C	LYS	I	498	−6.109	9.830	−43.994	1.00	55.29	C	C
  ATOM	10570	O	LYS	I	498	−6.409	9.763	−45.186	1.00	61.06	C	O
  ATOM	10571	N	ILE	I	499	−6.766	9.165	−43.047	1.00	52.22	C	N
  ATOM	10572	CA	ILE	I	499	−8.038	8.500	−43.323	1.00	48.26	C	C
  ATOM	10573	CB	ILE	I	499	−8.586	7.785	−42.076	1.00	20.00	C	C
  ATOM	10574	CG1	ILE	I	499	−7.657	6.642	−41.667	1.00	20.00	C	C
  ATOM	10575	CD1	ILE	I	499	−7.934	6.102	−40.286	1.00	20.00	C	C
  ATOM	10576	CG2	ILE	I	499	−9.994	7.267	−42.333	1.00	20.00	C	C
  ATOM	10577	C	ILE	I	499	−9.067	9.516	−43.798	1.00	49.07	C	C
  ATOM	10578	O	ILE	I	499	−9.858	9.244	−44.701	1.00	58.45	C	O
  ATOM	10579	N	ASN	I	500	−8.961	10.726	−43.265	1.00	51.02	C	N
  ATOM	10580	CA	ASN	I	500	−9.845	11.812	−43.644	1.00	52.06	C	C
  ATOM	10581	CB	ASN	I	500	−9.741	12.940	−42.625	1.00	20.00	C	C
  ATOM	10582	CG	ASN	I	500	−10.861	13.933	−42.753	1.00	20.00	C	C
  ATOM	10583	OD1	ASN	I	500	−11.927	13.622	−43.286	1.00	20.00	C	O
  ATOM	10584	ND2	ASN	I	500	−10.647	15.126	−42.232	1.00	20.00	C	N
  ATOM	10585	C	ASN	I	500	−9.552	12.345	−45.041	1.00	48.31	C	C
  ATOM	10586	O	ASN	I	500	−10.448	12.834	−45.729	1.00	56.89	C	O
  ATOM	10587	N	GLN	I	501	−8.283	12.300	−45.434	1.00	55.87	C	N
  ATOM	10588	CA	GLN	I	501	−7.900	12.610	−46.807	1.00	53.55	C	C
  ATOM	10589	CB	GLN	I	501	−6.384	12.797	−46.917	1.00	20.00	C	C
  ATOM	10590	CG	GLN	I	501	−5.851	13.987	−46.136	1.00	20.00	C	C
  ATOM	10591	CD	GLN	I	501	−4.338	14.093	−46.191	1.00	20.00	C	C
  ATOM	10592	OE1	GLN	I	501	−3.648	13.146	−46.576	1.00	20.00	C	O
  ATOM	10593	NE2	GLN	I	501	−3.814	15.247	−45.793	1.00	20.00	C	N
  ATOM	10594	C	GLN	I	501	−8.383	11.531	−47.777	1.00	45.67	C	C
  ATOM	10595	O	GLN	I	501	−8.980	11.837	−48.810	1.00	58.31	C	O
  ATOM	10596	N	SER	I	502	−8.234	10.273	−47.378	1.00	43.44	C	N
  ATOM	10597	CA	SER	I	502	−8.704	9.157	−48.189	1.00	45.40	C	C
  ATOM	10598	CB	SER	I	502	−8.367	7.830	−47.512	1.00	20.00	C	C
  ATOM	10599	OG	SER	I	502	−9.001	7.735	−46.250	1.00	20.00	C	O
  ATOM	10600	C	SER	I	502	−10.206	9.254	−48.413	1.00	55.15	C	C
  ATOM	10601	O	SER	I	502	−10.708	8.934	−49.490	1.00	52.57	C	O
  ATOM	10602	N	LEU	I	503	−10.920	9.673	−47.376	1.00	55.35	C	N
  ATOM	10603	CA	LEU	I	503	−12.366	9.798	−47.447	1.00	52.12	C	C
  ATOM	10604	CB	LEU	I	503	−12.950	10.025	−46.053	1.00	20.00	C	C
  ATOM	10605	CG	LEU	I	503	−12.783	8.856	−45.082	1.00	20.00	C	C
  ATOM	10606	CD1	LEU	I	503	−13.061	9.290	−43.653	1.00	20.00	C	C
  ATOM	10607	CD2	LEU	I	503	−13.685	7.704	−45.481	1.00	20.00	C	C
  ATOM	10608	C	LEU	I	503	−12.761	10.938	−48.371	1.00	55.74	C	C
  ATOM	10609	O	LEU	I	503	−13.782	10.869	−49.052	1.00	57.75	C	O
  ATOM	10610	N	ALA	I	504	−11.951	11.991	−48.382	1.00	57.22	C	N
  ATOM	10611	CA	ALA	I	504	−12.187	13.129	−49.261	1.00	59.12	C	C
  ATOM	10612	CB	ALA	I	504	−11.333	14.315	−48.831	1.00	20.00	C	C
  ATOM	10613	C	ALA	I	504	−11.902	12.760	−50.713	1.00	58.10	C	C
  ATOM	10614	O	ALA	I	504	−12.656	13.119	−51.618	1.00	63.64	C	O
  ATOM	10615	N	PHE	I	505	−10.813	12.029	−50.922	1.00	58.17	C	N
  ATOM	10616	CA	PHE	I	505	−10.485	11.505	−52.240	1.00	56.56	C	C
  ATOM	10617	CB	PHE	I	505	−9.180	10.698	−52.186	1.00	20.00	C	C
  ATOM	10618	CG	PHE	I	505	−7.971	11.517	−51.817	1.00	20.00	C	C
  ATOM	10619	CD1	PHE	I	505	−7.307	12.270	−52.773	1.00	20.00	C	C
  ATOM	10620	CE1	PHE	I	505	−6.230	13.063	−52.426	1.00	20.00	C	C
  ATOM	10621	CZ	PHE	I	505	−5.768	13.067	−51.125	1.00	20.00	C	C
  ATOM	10622	CE2	PHE	I	505	−6.376	12.270	−50.176	1.00	20.00	C	C
  ATOM	10623	CD2	PHE	I	505	−7.471	11.499	−50.524	1.00	20.00	C	C
  ATOM	10624	C	PHE	I	505	−11.625	10.637	−52.769	1.00	60.12	C	C
  ATOM	10625	O	PHE	I	505	−12.014	10.746	−53.934	1.00	65.46	C	O
  ATOM	10626	N	ILE	I	506	−12.214	9.844	−51.875	1.00	56.10	C	N
  ATOM	10627	CA	ILE	I	506	−13.355	8.991	−52.213	1.00	57.32	C	C
  ATOM	10628	CB	ILE	I	506	−13.782	8.109	−51.013	1.00	20.00	C	C
  ATOM	10629	CG1	ILE	I	506	−12.657	7.149	−50.619	1.00	20.00	C	C
  ATOM	10630	CD1	ILE	I	506	−12.804	6.591	−49.222	1.00	20.00	C	C
  ATOM	10631	CG2	ILE	I	506	−15.064	7.345	−51.330	1.00	20.00	C	C
  ATOM	10632	C	ILE	I	506	−14.556	9.818	−52.669	1.00	67.33	C	C
  ATOM	10633	O	ILE	I	506	−15.217	9.485	−53.652	1.00	76.99	C	O
  ATOM	10634	N	ARG	I	507	−14.855	10.878	−51.925	1.00	67.87	C	N
  ATOM	10635	CA	ARG	I	507	−15.936	11.788	−52.287	1.00	62.11	C	C
  ATOM	10636	CB	ARG	I	507	−16.087	12.898	−51.240	1.00	20.00	C	C
  ATOM	10637	CG	ARG	I	507	−16.795	12.450	−49.963	1.00	20.00	C	C
  ATOM	10638	CD	ARG	I	507	−16.736	13.504	−48.861	1.00	20.00	C	C
  ATOM	10639	NE	ARG	I	507	−17.140	12.957	−47.566	1.00	20.00	C	N
  ATOM	10640	CZ	ARG	I	507	−17.292	13.683	−46.463	1.00	20.00	C	C
  ATOM	10641	NH1	ARG	I	507	−17.083	14.992	−46.499	1.00	20.00	C	N
  ATOM	10642	NH2	ARG	I	507	−17.687	13.106	−45.335	1.00	20.00	C	N
  ATOM	10643	C	ARG	I	507	−15.685	12.391	−53.659	1.00	67.30	C	C
  ATOM	10644	O	ARG	I	507	−16.488	12.224	−54.574	1.00	67.02	C	O
  ATOM	10645	N	LYS	I	508	−14.518	13.001	−53.823	1.00	66.83	C	N
  ATOM	10646	CA	LYS	I	508	−14.125	13.546	−55.112	1.00	68.12	C	C
  ATOM	10647	CB	LYS	I	508	−12.693	14.086	−55.052	1.00	20.00	C	C
  ATOM	10648	CG	LYS	I	508	−12.522	15.286	−54.117	1.00	20.00	C	C
  ATOM	10649	CD	LYS	I	508	−11.072	15.750	−54.046	1.00	20.00	C	C
  ATOM	10650	CE	LYS	I	508	−10.912	16.933	−53.098	1.00	20.00	C	C
  ATOM	10651	NZ	LYS	I	508	−9.486	17.329	−52.912	1.00	20.00	C	N
  ATOM	10652	C	LYS	I	508	−14.275	12.499	−56.215	1.00	65.22	C	C
  ATOM	10653	O	LYS	I	508	−15.005	12.710	−57.183	1.00	72.34	C	O
  ATOM	10654	N	SER	I	509	−13.727	11.312	−55.973	1.00	64.87	C	N
  ATOM	10655	CA	SER	I	509	−13.783	10.230	−56.949	1.00	56.47	C	C
  ATOM	10656	CB	SER	I	509	−13.014	9.008	−56.445	1.00	20.00	C	C
  ATOM	10657	OG	SER	I	509	−13.561	8.528	−55.232	1.00	20.00	C	O
  ATOM	10658	C	SER	I	509	−15.220	9.847	−57.299	1.00	56.96	C	C
  ATOM	10659	O	SER	I	509	−15.537	9.599	−58.461	1.00	65.57	C	O
  ATOM	10660	N	ASP	I	510	−16.077	9.760	−56.285	1.00	64.34	C	N
  ATOM	10661	CA	ASP	I	510	−17.478	9.402	−56.500	1.00	64.83	C	C
  ATOM	10662	CB	ASP	I	510	−18.217	9.244	−55.161	1.00	20.00	C	C
  ATOM	10663	CG	ASP	I	510	−17.827	7.975	−54.416	1.00	20.00	C	C
  ATOM	10664	OD1	ASP	I	510	−17.292	7.044	−55.050	1.00	20.00	C	O
  ATOM	10665	OD2	ASP	I	510	−18.083	7.900	−53.197	1.00	20.00	C	O
  ATOM	10666	C	ASP	I	510	−18.173	10.458	−57.356	1.00	62.11	C	C
  ATOM	10667	O	ASP	I	510	−18.723	10.150	−58.412	1.00	67.61	C	O
  ATOM	10668	N	GLU	I	511	−18.078	11.713	−56.928	1.00	64.95	C	N
  ATOM	10669	CA	GLU	I	511	−18.673	12.822	−57.664	1.00	60.64	C	C
  ATOM	10670	CB	GLU	I	511	−18.175	14.162	−57.117	1.00	20.00	C	C
  ATOM	10671	CG	GLU	I	511	−18.700	14.509	−55.736	1.00	20.00	C	C
  ATOM	10672	CD	GLU	I	511	−18.061	15.767	−55.172	1.00	20.00	C	C
  ATOM	10673	OE1	GLU	I	511	−17.166	16.329	−55.841	1.00	20.00	C	O
  ATOM	10674	OE2	GLU	I	511	−18.506	16.237	−54.102	1.00	20.00	C	O
  ATOM	10675	C	GLU	I	511	−18.377	12.729	−59.159	1.00	59.91	C	C
  ATOM	10676	O	GLU	I	511	−19.245	13.008	−59.983	1.00	55.45	C	O
  ATOM	10677	N	LEU	I	512	−17.122	12.450	−59.503	1.00	44.35	C	N
  ATOM	10678	CA	LEU	I	512	−16.712	12.392	−60.904	1.00	49.60	C	C
  ATOM	10679	CB	LEU	I	512	−15.196	12.240	−61.021	1.00	20.00	C	C
  ATOM	10680	CG	LEU	I	512	−14.353	13.460	−60.658	1.00	20.00	C	C
  ATOM	10681	CD1	LEU	I	512	−12.894	13.181	−60.963	1.00	20.00	C	C
  ATOM	10682	CD2	LEU	I	512	−14.831	14.678	−61.424	1.00	20.00	C	C
  ATOM	10683	C	LEU	I	512	−17.396	11.239	−61.621	1.00	58.00	C	C
  ATOM	10684	O	LEU	I	512	−17.946	11.411	−62.708	1.00	55.11	C	O
  ATOM	10685	N	LEU	I	513	−17.306	10.051	−61.036	1.00	57.91	C	N
  ATOM	10686	CA	LEU	I	513	−17.901	8.870	−61.636	1.00	57.49	C	C
  ATOM	10687	CB	LEU	I	513	−17.632	7.629	−60.774	1.00	20.00	C	C
  ATOM	10688	CG	LEU	I	513	−16.169	7.179	−60.678	1.00	20.00	C	C
  ATOM	10689	CD1	LEU	I	513	−15.992	6.055	−59.670	1.00	20.00	C	C
  ATOM	10690	CD2	LEU	I	513	−15.637	6.768	−62.042	1.00	20.00	C	C
  ATOM	10691	C	LEU	I	513	−19.399	9.075	−61.852	1.00	58.78	C	C
  ATOM	10692	O	LEU	I	513	−19.913	8.812	−62.940	1.00	59.88	C	O
  ATOM	10693	N	HIS	I	514	−20.054	9.718	−60.888	1.00	60.07	C	N
  ATOM	10694	CA	HIS	I	514	−21.494	9.975	−60.982	1.00	62.82	C	C
  ATOM	10695	CB	HIS	I	514	−22.058	10.454	−59.635	1.00	20.00	C	C
  ATOM	10696	CG	HIS	I	514	−21.878	9.472	−58.517	1.00	20.00	C	C
  ATOM	10697	ND1	HIS	I	514	−22.551	8.269	−58.465	1.00	20.00	C	N
  ATOM	10698	CE1	HIS	I	514	−22.192	7.612	−57.376	1.00	20.00	C	C
  ATOM	10699	NE2	HIS	I	514	−21.304	8.342	−56.723	1.00	20.00	C	N
  ATOM	10700	CD2	HIS	I	514	−21.104	9.517	−57.407	1.00	20.00	C	C
  ATOM	10701	C	HIS	I	514	−21.799	10.989	−62.087	1.00	65.10	C	C
  ATOM	10702	O	HIS	I	514	−22.898	11.002	−62.647	1.00	66.73	C	O
  ATOM	10703	N	ASN	I	515	−20.795	11.787	−62.441	1.00	63.45	C	N
  ATOM	10704	CA	ASN	I	515	−20.932	12.782	−63.499	1.00	56.53	C	C
  ATOM	10705	CB	ASN	I	515	−19.903	13.909	−63.317	1.00	20.00	C	C
  ATOM	10706	CG	ASN	I	515	−20.243	14.838	−62.159	1.00	20.00	C	C
  ATOM	10707	OD1	ASN	I	515	−21.400	14.948	−61.756	1.00	20.00	C	O
  ATOM	10708	ND2	ASN	I	515	−19.238	15.544	−61.652	1.00	20.00	C	N
  ATOM	10709	C	ASN	I	515	−20.765	12.134	−64.868	1.00	60.06	C	C
  ATOM	10710	O	ASN	I	515	−21.518	12.422	−65.799	1.00	66.48	C	O
  ATOM	10711	N	VAL	I	516	−19.829	11.197	−64.959	1.00	54.29	C	N
  ATOM	10712	CA	VAL	I	516	−19.617	10.460	−66.195	1.00	52.70	C	C
  ATOM	10713	CB	VAL	I	516	−18.407	9.523	−66.097	1.00	20.00	C	C
  ATOM	10714	CG1	VAL	I	516	−18.398	8.554	−67.267	1.00	20.00	C	C
  ATOM	10715	CG2	VAL	I	516	−17.122	10.330	−66.063	1.00	20.00	C	C
  ATOM	10716	C	VAL	I	516	−20.850	9.645	−66.551	1.00	60.10	C	C
  ATOM	10717	O	VAL	I	516	−21.306	9.662	−67.693	1.00	61.55	C	O
  ATOM	10718	N	ASN	I	517	−21.432	8.998	−65.549	1.00	69.10	C	N
  ATOM	10719	CA	ASN	I	517	−22.648	8.224	−65.749	1.00	67.75	C	C
  ATOM	10720	CB	ASN	I	517	−23.135	7.652	−64.421	1.00	20.00	C	C
  ATOM	10721	CG	ASN	I	517	−22.254	6.530	−63.914	1.00	20.00	C	C
  ATOM	10722	OD1	ASN	I	517	−21.467	5.954	−64.667	1.00	20.00	C	O
  ATOM	10723	ND2	ASN	I	517	−22.368	6.226	−62.627	1.00	20.00	C	N
  ATOM	10724	C	ASN	I	517	−23.751	9.051	−66.394	1.00	71.17	C	C
  ATOM	10725	O	ASN	I	517	−24.535	8.544	−67.196	1.00	66.42	C	O
  ATOM	10726	N	ALA	I	518	−23.811	10.326	−66.028	1.00	72.11	C	N
  ATOM	10727	CA	ALA	I	518	−24.811	11.232	−66.571	1.00	74.82	C	C
  ATOM	10728	CB	ALA	I	518	−24.936	12.464	−65.692	1.00	20.00	C	C
  ATOM	10729	C	ALA	I	518	−24.471	11.628	−68.004	1.00	70.11	C	C
  ATOM	10730	O	ALA	I	518	−25.328	11.590	−68.886	1.00	65.18	C	O
  ATOM	10731	N	GLY	I	519	−23.212	11.989	−68.230	1.00	56.07	C	N
  ATOM	10732	CA	GLY	I	519	−22.709	12.224	−69.577	1.00	53.01	C	C
  ATOM	10733	C	GLY	I	519	−22.906	11.026	−70.483	1.00	63.58	C	C
  ATOM	10734	O	GLY	I	519	−23.221	11.174	−71.663	1.00	69.35	C	O
  ATOM	10735	N	LYS	I	520	−22.776	9.833	−69.912	1.00	58.33	C	N
  ATOM	10736	CA	LYS	I	520	−22.996	8.592	−70.647	1.00	53.44	C	C
  ATOM	10737	CB	LYS	I	520	−22.655	7.389	−69.767	1.00	20.00	C	C
  ATOM	10738	CG	LYS	I	520	−21.194	7.319	−69.368	1.00	20.00	C	C
  ATOM	10739	CD	LYS	I	520	−20.915	6.097	−68.525	1.00	20.00	C	C
  ATOM	10740	CE	LYS	I	520	−19.428	5.920	−68.314	1.00	20.00	C	C
  ATOM	10741	NZ	LYS	I	520	−19.148	4.767	−67.417	1.00	20.00	C	N
  ATOM	10742	C	LYS	I	520	−24.437	8.485	−71.121	1.00	58.24	C	C
  ATOM	10743	O	LYS	I	520	−24.714	7.920	−72.179	1.00	48.60	C	O
  ATOM	10744	N	SER	I	521	−25.354	8.971	−70.293	1.00	67.19	C	N
  ATOM	10745	CA	SER	I	521	−26.772	8.995	−70.632	1.00	60.42	C	C
  ATOM	10746	CB	SER	I	521	−27.588	9.481	−69.436	1.00	20.00	C	C
  ATOM	10747	OG	SER	I	521	−27.281	10.830	−69.130	1.00	20.00	C	O
  ATOM	10748	C	SER	I	521	−27.047	9.892	−71.837	1.00	54.19	C	C
  ATOM	10749	O	SER	I	521	−27.767	9.506	−72.758	1.00	65.36	C	O
  ATOM	10750	N	THR	I	522	−26.556	11.124	−71.770	1.00	50.09	C	N
  ATOM	10751	CA	THR	I	522	−26.650	12.048	−72.892	1.00	57.59	C	C
  ATOM	10752	CB	THR	I	522	−25.950	13.377	−72.579	1.00	20.00	C	C
  ATOM	10753	OG1	THR	I	522	−24.538	13.159	−72.466	1.00	20.00	C	O
  ATOM	10754	CG2	THR	I	522	−26.478	13.957	−71.275	1.00	20.00	C	C
  ATOM	10755	C	THR	I	522	−26.040	11.450	−74.153	1.00	59.16	C	C
  ATOM	10756	O	THR	I	522	−26.682	11.416	−75.202	1.00	65.90	C	O
  ATOM	10757	N	THR	I	523	−24.840	10.891	−74.020	1.00	52.59	C	N
  ATOM	10758	CA	THR	I	523	−24.151	10.267	−75.148	1.00	42.19	C	C
  ATOM	10759	CB	THR	I	523	−22.805	9.649	−74.725	1.00	20.00	C	C
  ATOM	10760	OG1	THR	I	523	−23.027	8.645	−73.726	1.00	20.00	C	O
  ATOM	10761	CG2	THR	I	523	−21.876	10.722	−74.172	1.00	20.00	C	C
  ATOM	10762	C	THR	I	523	−25.002	9.194	−75.822	1.00	48.90	C	C
  ATOM	10763	O	THR	I	523	−24.991	9.059	−77.047	1.00	63.19	C	O
  ATOM	10764	N	ASN	I	524	−25.694	8.395	−75.018	1.00	52.51	C	N
  ATOM	10765	CA	ASN	I	524	−26.597	7.386	−75.553	1.00	57.54	C	C
  ATOM	10766	CB	ASN	I	524	−27.089	6.458	−74.444	1.00	20.00	C	C
  ATOM	10767	CG	ASN	I	524	−26.002	5.533	−73.941	1.00	20.00	C	C
  ATOM	10768	OD1	ASN	I	524	−25.000	5.316	−74.620	1.00	20.00	C	O
  ATOM	10769	ND2	ASN	I	524	−26.153	5.050	−72.714	1.00	20.00	C	N
  ATOM	10770	C	ASN	I	524	−27.776	7.996	−76.302	1.00	54.12	C	C
  ATOM	10771	O	ASN	I	524	−28.076	7.601	−77.428	1.00	61.31	C	O
  ATOM	10772	N	SER	I	525	−28.372	9.027	−75.714	1.00	48.97	C	N
  ATOM	10773	CA	SER	I	525	−29.483	9.734	−76.336	1.00	64.81	C	C
  ATOM	10774	CB	SER	I	525	−29.930	10.885	−75.441	1.00	61.22	C	C
  ATOM	10775	OG	SER	I	525	−29.691	10.571	−74.078	1.00	85.90	C	O
  ATOM	10776	C	SER	I	525	−29.114	10.265	−77.713	1.00	69.67	C	C
  ATOM	10777	O	SER	I	525	−29.974	10.417	−78.580	1.00	72.60	C	O
  ATOM	10778	N	LYS	I	526	−27.853	10.647	−77.872	1.00	66.06	C	N
  ATOM	10779	CA	LYS	I	526	−27.365	11.130	−79.154	1.00	63.67	C	C
  ATOM	10780	CB	LYS	I	526	−26.043	11.874	−78.980	1.00	70.55	C	C
  ATOM	10781	CG	LYS	I	526	−26.196	13.332	−78.608	1.00	75.29	C	C
  ATOM	10782	CD	LYS	I	526	−24.898	13.870	−78.032	1.00	85.03	C	C
  ATOM	10783	CE	LYS	I	526	−25.144	15.017	−77.067	1.00	82.65	C	C
  ATOM	10784	NZ	LYS	I	526	−24.040	15.141	−76.075	1.00	73.89	C	N
  ATOM	10785	C	LYS	I	526	−27.182	9.975	−80.124	1.00	55.36	C	C
  ATOM	10786	O	LYS	I	526	−27.591	10.050	−81.283	1.00	70.69	C	O
  ATOM	10787	N	ILE	I	527	−26.593	8.892	−79.634	1.00	57.52	C	N
  ATOM	10788	CA	ILE	I	527	−26.355	7.723	−80.461	1.00	58.48	C	C
  ATOM	10789	CB	ILE	I	527	−25.712	6.589	−79.650	1.00	57.00	C	C
  ATOM	10790	CG1	ILE	I	527	−24.414	7.071	−78.993	1.00	49.07	C	C
  ATOM	10791	CD1	ILE	I	527	−23.516	7.882	−79.906	1.00	46.18	C	C
  ATOM	10792	CG2	ILE	I	527	−25.469	5.370	−80.530	1.00	52.63	C	C
  ATOM	10793	C	ILE	I	527	−27.649	7.230	−81.097	1.00	65.20	C	C
  ATOM	10794	O	ILE	I	527	−27.705	7.000	−82.304	1.00	66.48	C	O
  ATOM	10795	N	TYR	I	528	−28.705	7.141	−80.293	1.00	69.78	C	N
  ATOM	10796	CA	TYR	I	528	−30.027	6.783	−80.798	1.00	72.52	C	C
  ATOM	10797	CB	TYR	I	528	−31.080	6.916	−79.695	1.00	73.16	C	C
  ATOM	10798	CG	TYR	I	528	−30.768	6.138	−78.433	1.00	76.94	C	C
  ATOM	10799	CD1	TYR	I	528	−31.402	6.444	−77.233	1.00	70.95	C	C
  ATOM	10800	CE1	TYR	I	528	−31.123	5.739	−76.074	1.00	67.73	C	C
  ATOM	10801	CZ	TYR	I	528	−30.200	4.712	−76.103	1.00	71.89	C	C
  ATOM	10802	OH	TYR	I	528	−29.927	4.009	−74.954	1.00	75.44	C	O
  ATOM	10803	CE2	TYR	I	528	−29.534	4.407	−77.273	1.00	77.03	C	C
  ATOM	10804	CD2	TYR	I	528	−29.818	5.120	−78.431	1.00	77.84	C	C
  ATOM	10805	C	TYR	I	528	−30.414	7.661	−81.985	1.00	71.63	C	C
  ATOM	10806	O	TYR	I	528	−30.720	7.162	−83.069	1.00	84.20	C	O
  ATOM	10807	N	HIS	I	529	−30.470	8.966	−81.748	1.00	67.69	C	N
  ATOM	10808	CA	HIS	I	529	−30.934	9.902	−82.759	1.00	60.28	C	C
  ATOM	10809	CB	HIS	I	529	−30.900	11.336	−82.218	1.00	67.84	C	C
  ATOM	10810	CG	HIS	I	529	−31.927	11.615	−81.162	1.00	88.54	C	C
  ATOM	10811	ND1	HIS	I	529	−32.439	12.875	−80.934	1.00	93.34	C	N
  ATOM	10812	CE1	HIS	I	529	−33.289	12.828	−79.924	1.00	86.23	C	C
  ATOM	10813	NE2	HIS	I	529	−33.346	11.583	−79.486	1.00	91.95	C	N
  ATOM	10814	CD2	HIS	I	529	−32.495	10.807	−80.235	1.00	93.77	C	C
  ATOM	10815	C	HIS	I	529	−30.094	9.785	−84.029	1.00	63.30	C	C
  ATOM	10816	O	HIS	I	529	−30.632	9.642	−85.127	1.00	61.02	C	O
  ATOM	10817	N	ILE	I	530	−28.775	9.752	−83.867	1.00	59.79	C	N
  ATOM	10818	CA	ILE	I	530	−27.886	9.457	−84.984	1.00	45.70	C	C
  ATOM	10819	CB	ILE	I	530	−26.413	9.365	−84.536	1.00	40.57	C	C
  ATOM	10820	CG1	ILE	I	530	−25.854	10.764	−84.270	1.00	42.86	C	C
  ATOM	10821	CD1	ILE	I	530	−24.376	10.902	−84.570	1.00	51.01	C	C
  ATOM	10822	CG2	ILE	I	530	−25.575	8.662	−85.596	1.00	35.31	C	C
  ATOM	10823	C	ILE	I	530	−28.301	8.153	−85.660	1.00	57.52	C	C
  ATOM	10824	O	ILE	I	530	−28.637	8.136	−86.845	1.00	71.18	C	O
  ATOM	10825	N	GLU	I	531	−28.485	7.122	−84.841	1.00	67.55	C	N
  ATOM	10826	CA	GLU	I	531	−28.876	5.801	−85.321	1.00	69.79	C	C
  ATOM	10827	CB	GLU	I	531	−29.114	4.869	−84.134	1.00	84.02	C	C
  ATOM	10828	CG	GLU	I	531	−28.794	3.415	−84.402	1.00	104.22	C	C
  ATOM	10829	CD	GLU	I	531	−28.980	2.551	−83.170	1.00	116.08	C	C
  ATOM	10830	OE1	GLU	I	531	−28.474	2.927	−82.091	1.00	118.71	C	O
  ATOM	10831	OE2	GLU	I	531	−29.736	1.564	−83.255	1.00	119.69	C	O
  ATOM	10832	C	GLU	I	531	−30.145	5.890	−86.151	1.00	64.87	C	C
  ATOM	10833	O	GLU	I	531	−30.218	5.343	−87.250	1.00	55.58	C	O
  ATOM	10834	N	ASN	I	532	−31.177	6.489	−85.566	1.00	65.70	C	N
  ATOM	10835	CA	ASN	I	532	−32.459	6.657	−86.240	1.00	64.16	C	C
  ATOM	10836	CB	ASN	I	532	−33.475	7.303	−85.296	1.00	60.58	C	C
  ATOM	10837	CG	ASN	I	532	−34.859	7.396	−85.905	1.00	67.75	C	C
  ATOM	10838	OD1	ASN	I	532	−35.480	6.381	−86.221	1.00	53.59	C	O
  ATOM	10839	ND2	ASN	I	532	−35.352	8.618	−86.072	1.00	61.81	C	N
  ATOM	10840	C	ASN	I	532	−32.330	7.486	−87.517	1.00	72.17	C	C
  ATOM	10841	O	ASN	I	532	−32.999	7.220	−88.517	1.00	85.75	C	O
  ATOM	10842	N	GLU	I	533	−31.469	8.495	−87.470	1.00	79.68	C	N
  ATOM	10843	CA	GLU	I	533	−31.248	9.372	−88.611	1.00	71.96	C	C
  ATOM	10844	CB	GLU	I	533	−30.422	10.590	−88.186	1.00	67.87	C	C
  ATOM	10845	CG	GLU	I	533	−30.518	11.797	−89.125	1.00	81.94	C	C
  ATOM	10846	CD	GLU	I	533	−31.932	12.348	−89.256	1.00	92.79	C	C
  ATOM	10847	OE1	GLU	I	533	−32.529	12.729	−88.227	1.00	95.90	C	O
  ATOM	10848	OE2	GLU	I	533	−32.399	12.511	−90.403	1.00	93.14	C	O
  ATOM	10849	C	GLU	I	533	−30.546	8.622	−89.738	1.00	68.54	C	C
  ATOM	10850	O	GLU	I	533	−30.737	8.928	−90.914	1.00	79.29	C	O
  ATOM	10851	N	ILE	I	534	−29.742	7.631	−89.367	1.00	69.50	C	N
  ATOM	10852	CA	ILE	I	534	−29.047	6.796	−90.342	1.00	72.55	C	C
  ATOM	10853	CB	ILE	I	534	−27.786	6.137	−89.729	1.00	79.55	C	C
  ATOM	10854	CG1	ILE	I	534	−26.779	7.205	−89.298	1.00	80.41	C	C
  ATOM	10855	CD1	ILE	I	534	−26.687	8.374	−90.254	1.00	89.38	C	C
  ATOM	10856	CG2	ILE	I	534	−27.138	5.186	−90.724	1.00	78.63	C	C
  ATOM	10857	C	ILE	I	534	−29.972	5.707	−90.883	1.00	74.92	C	C
  ATOM	10858	O	ILE	I	534	−29.725	5.139	−91.948	1.00	81.01	C	O
  ATOM	10859	N	ALA	I	535	−31.028	5.411	−90.130	1.00	79.52	C	N
  ATOM	10860	CA	ALA	I	535	−32.056	4.474	−90.573	1.00	82.64	C	C
  ATOM	10861	CB	ALA	I	535	−32.890	4.001	−89.386	1.00	75.39	C	C
  ATOM	10862	C	ALA	I	535	−32.956	5.093	−91.645	1.00	81.39	C	C
  ATOM	10863	O	ALA	I	535	−33.323	4.435	−92.622	1.00	85.54	C	O
  ATOM	10864	N	ARG	I	536	−33.274	6.373	−91.474	1.00	78.41	C	N
  ATOM	10865	CA	ARG	I	536	−34.100	7.098	−92.435	1.00	83.27	C	C
  ATOM	10866	CB	ARG	I	536	−34.664	8.372	−91.804	1.00	84.58	C	C
  ATOM	10867	CG	ARG	I	536	−35.623	8.123	−90.651	1.00	103.24	C	C
  ATOM	10868	CD	ARG	I	536	−36.750	9.145	−90.630	1.00	114.72	C	C
  ATOM	10869	NE	ARG	I	536	−36.250	10.513	−90.521	1.00	117.80	C	N
  ATOM	10870	CZ	ARG	I	536	−37.009	11.598	−90.638	1.00	116.66	C	C
  ATOM	10871	NH1	ARG	I	536	−38.311	11.478	−90.863	1.00	114.57	C	N
  ATOM	10872	NH2	ARG	I	536	−36.470	12.803	−90.520	1.00	116.38	C	N
  ATOM	10873	C	ARG	I	536	−33.323	7.440	−93.703	1.00	82.20	C	C
  ATOM	10874	O	ARG	I	536	−33.838	7.298	−94.812	1.00	86.28	C	O
  ATOM	10875	N	ILE	I	537	−32.114	7.964	−93.532	1.00	77.08	C	N
  ATOM	10876	CA	ILE	I	537	−31.219	8.194	−94.659	1.00	66.79	C	C
  ATOM	10877	CB	ILE	I	537	−29.908	8.850	−94.204	1.00	64.76	C	C
  ATOM	10878	CG1	ILE	I	537	−30.176	10.251	−93.649	1.00	66.92	C	C
  ATOM	10879	CD1	ILE	I	537	−29.017	10.829	−92.869	1.00	70.83	C	C
  ATOM	10880	CG2	ILE	I	537	−28.926	8.905	−95.354	1.00	51.02	C	C
  ATOM	10881	C	ILE	I	537	−30.900	6.892	−95.397	1.00	74.94	C	C
  ATOM	10882	O	ILE	I	537	−30.628	6.898	−96.599	1.00	97.16	C	O
  ATOM	10883	N	LYS	I	538	−30.959	5.777	−94.675	1.00	75.09	C	N
  ATOM	10884	CA	LYS	I	538	−30.769	4.462	−95.275	1.00	90.28	C	C
  ATOM	10885	CB	LYS	I	538	−30.228	3.472	−94.240	1.00	93.73	C	C
  ATOM	10886	CG	LYS	I	538	−29.538	2.255	−94.850	1.00	96.60	C	C
  ATOM	10887	CD	LYS	I	538	−29.040	1.288	−93.786	1.00	95.37	C	C
  ATOM	10888	CE	LYS	I	538	−28.132	0.235	−94.399	1.00	100.63	C	C
  ATOM	10889	NZ	LYS	I	538	−27.652	−0.753	−93.397	1.00	99.58	C	N
  ATOM	10890	C	LYS	I	538	−32.062	3.927	−95.884	1.00	102.20	C	C
  ATOM	10891	O	LYS	I	538	−32.083	2.839	−96.461	1.00	112.11	C	O
  ATOM	10892	N	LYS	I	539	−33.126	4.722	−95.795	1.00	105.15	C	N
  ATOM	10893	CA	LYS	I	539	−34.422	4.355	−96.360	1.00	105.65	C	C
  ATOM	10894	CB	LYS	I	539	−35.548	4.745	−95.398	1.00	110.12	C	C
  ATOM	10895	CG	LYS	I	539	−36.926	4.269	−95.823	1.00	113.31	C	C
  ATOM	10896	CD	LYS	I	539	−38.013	4.785	−94.889	1.00	114.26	C	C
  ATOM	10897	CE	LYS	I	539	−39.395	4.373	−95.378	1.00	118.39	C	C
  ATOM	10898	NZ	LYS	I	539	−40.449	4.593	−94.352	1.00	121.77	C	N
  ATOM	10899	C	LYS	I	539	−34.646	5.008	−97.726	1.00	108.88	C	C
  ATOM	10900	O	LYS	I	539	−35.717	4.876	−98.321	1.00	110.77	C	O
  ATOM	10901	N	LEU	I	540	−33.612	5.675	−98.232	1.00	111.50	C	N
  ATOM	10902	CA	LEU	I	540	−33.668	6.309	−99.544	1.00	110.31	C	C
  ATOM	10903	CB	LEU	I	540	−33.272	7.777	−99.435	1.00	101.19	C	C
  ATOM	10904	CG	LEU	I	540	−34.219	8.611	−98.581	1.00	94.26	C	C
  ATOM	10905	CD1	LEU	I	540	−34.093	10.066	−98.978	1.00	86.40	C	C
  ATOM	10906	CD2	LEU	I	540	−35.646	8.133	−98.783	1.00	84.54	C	C
  ATOM	10907	C	LEU	I	540	−32.738	5.601	−100.513	1.00	118.37	C	C
  ATOM	10908	O	LEU	I	540	−32.526	6.059	−101.634	1.00	116.71	C	O
  ATOM	10909	N	ILE	I	541	−32.163	4.493	−100.056	1.00	130.80	C	N
  ATOM	10910	CA	ILE	I	541	−31.273	3.686	−100.882	1.00	140.48	C	C
  ATOM	10911	CB	ILE	I	541	−29.821	4.210	−100.840	1.00	138.99	C	C
  ATOM	10912	CG1	ILE	I	541	−29.770	5.686	−101.240	1.00	133.30	C	C
  ATOM	10913	CD1	ILE	I	541	−30.650	6.027	−102.420	1.00	136.26	C	C
  ATOM	10914	CG2	ILE	I	541	−28.924	3.372	−101.744	1.00	136.12	C	C
  ATOM	10915	C	ILE	I	541	−31.289	2.233	−100.426	1.00	144.97	C	C
  ATOM	10916	O	ILE	I	541	−30.938	1.333	−101.188	1.00	145.83	C	O
  ATOM	10917	N	GLY	I	542	−31.724	2.004	−99.191	1.00	148.77	C	N
  ATOM	10918	CA	GLY	I	542	−31.789	0.655	−98.645	1.00	153.58	C	C
  ATOM	10919	C	GLY	I	542	−33.208	0.136	−98.534	1.00	160.45	C	C
  ATOM	10920	O	GLY	I	542	−34.109	0.602	−99.233	1.00	163.41	C	O
  ATOM	10921	N	GLU	I	543	−33.412	−0.799	−97.611	1.00	163.83	C	N
  ATOM	10922	CA	GLU	I	543	−34.718	−1.409	−97.392	1.00	165.52	C	C
  ATOM	10923	CB	GLU	I	543	−34.576	−2.673	−96.538	1.00	158.94	C	C
  ATOM	10928	C	GLU	I	543	−35.680	−0.430	−96.729	1.00	168.27	C	C
  ATOM	10929	O	GLU	I	543	−35.373	0.753	−96.584	1.00	167.37	C	O
  ATOM	10930	C1	NAG	J	1535	24.849	−25.592	34.903	1.00	72.96		C
  ATOM	10931	C2	NAG	J	1535	24.818	−27.046	34.438	1.00	83.63		C
  ATOM	10932	N2	NAG	J	1535	23.774	−27.757	35.160	1.00	85.81		N
  ATOM	10933	C7	NAG	J	1535	23.087	−28.774	34.642	1.00	87.77		C
  ATOM	10934	O7	NAG	J	1535	23.376	−29.307	33.573	1.00	89.34		O
  ATOM	10935	C8	NAG	J	1535	21.991	−29.339	35.498	1.00	86.84		C
  ATOM	10936	C3	NAG	J	1535	26.183	−27.682	34.695	1.00	85.86		C
  ATOM	10937	O3	NAG	J	1535	27.009	−27.488	33.569	1.00	84.14		O
  ATOM	10938	C4	NAG	J	1535	26.823	−27.025	35.913	1.00	88.88		C
  ATOM	10939	O4	NAG	J	1535	27.730	−27.923	36.530	1.00	96.14		O
  ATOM	10940	C5	NAG	J	1535	25.692	−26.643	36.863	1.00	85.57		C
  ATOM	10941	C6	NAG	J	1535	26.185	−26.278	38.259	1.00	85.54		C
  ATOM	10942	O6	NAG	J	1535	27.307	−25.431	38.159	1.00	85.75		O
  ATOM	10943	O5	NAG	J	1535	24.941	−25.575	36.317	1.00	79.39		O
  ATOM	10944	C1	NAG	J	1536	29.076	−27.393	36.512	1.00	101.26		C
  ATOM	10945	C2	NAG	J	1536	29.807	−27.737	37.810	1.00	103.37		C
  ATOM	10946	N2	NAG	J	1536	30.222	−26.531	38.504	1.00	104.36		N
  ATOM	10947	C7	NAG	J	1536	30.339	−26.483	39.830	1.00	104.07		C
  ATOM	10948	O7	NAG	J	1536	30.062	−27.429	40.566	1.00	103.82		O
  ATOM	10949	C8	NAG	J	1536	30.810	−25.183	40.413	1.00	103.07		C
  ATOM	10950	C3	NAG	J	1536	31.013	−28.638	37.568	1.00	104.12		C
  ATOM	10951	O3	NAG	J	1536	31.411	−29.224	38.788	1.00	103.63		O
  ATOM	10952	C4	NAG	J	1536	30.689	−29.737	36.565	1.00	104.68		C
  ATOM	10953	O4	NAG	J	1536	31.865	−30.456	36.266	1.00	105.46		O
  ATOM	10954	C5	NAG	J	1536	30.104	−29.166	35.277	1.00	104.39		C
  ATOM	10955	C6	NAG	J	1536	28.856	−29.920	34.835	1.00	104.32		C
  ATOM	10956	O6	NAG	J	1536	28.929	−30.178	33.450	1.00	104.22		O
  ATOM	10957	O5	NAG	J	1536	29.840	−27.780	35.384	1.00	103.22		O
  ATOM	10958	C1	NAG	J	1545	−15.969	−4.075	−43.033	1.00	56.85		C
  ATOM	10959	C2	NAG	J	1545	−16.105	−5.488	−42.448	1.00	66.44		C
  ATOM	10960	N2	NAG	J	1545	−14.794	−6.111	−42.415	1.00	69.47		N
  ATOM	10961	C7	NAG	J	1545	−13.913	−5.853	−41.453	1.00	72.43		C
  ATOM	10962	O7	NAG	J	1545	−14.178	−5.152	−40.481	1.00	73.31		O
  ATOM	10963	C8	NAG	J	1545	−12.558	−6.484	−41.587	1.00	72.22		C
  ATOM	10964	C3	NAG	J	1545	−17.084	−6.379	−43.216	1.00	68.81		C
  ATOM	10965	O3	NAG	J	1545	−17.443	−7.508	−42.449	1.00	68.22		O
  ATOM	10966	C4	NAG	J	1545	−18.314	−5.557	−43.561	1.00	71.19		C
  ATOM	10967	O4	NAG	J	1545	−19.356	−6.295	−44.161	1.00	76.87		O
  ATOM	10968	C5	NAG	J	1545	−17.827	−4.416	−44.429	1.00	67.79		C
  ATOM	10969	C6	NAG	J	1545	−18.955	−3.707	−45.166	1.00	67.71		C
  ATOM	10970	O6	NAG	J	1545	−19.545	−2.754	−44.311	1.00	67.33		O
  ATOM	10971	O5	NAG	J	1545	−17.181	−3.544	−43.536	1.00	62.66		O
  ATOM	10972	C1	NAG	J	1546	−20.251	−6.690	−43.101	1.00	83.18		C
  ATOM	10973	C2	NAG	J	1546	−21.616	−5.983	−43.168	1.00	85.51		C
  ATOM	10974	N2	NAG	J	1546	−21.766	−5.147	−41.990	1.00	84.12		N
  ATOM	10975	C7	NAG	J	1546	−21.679	−3.817	−41.993	1.00	82.64		C
  ATOM	10976	O7	NAG	J	1546	−21.413	−3.148	−42.990	1.00	81.92		O
  ATOM	10977	C8	NAG	J	1546	−21.866	−3.149	−40.663	1.00	80.96		C
  ATOM	10978	C3	NAG	J	1546	−22.846	−6.884	−43.261	1.00	87.47		C
  ATOM	10979	O3	NAG	J	1546	−23.679	−6.482	−44.325	1.00	87.96		O
  ATOM	10980	C4	NAG	J	1546	−22.495	−8.356	−43.377	1.00	87.61		C
  ATOM	10981	O4	NAG	J	1546	−23.635	−9.125	−43.071	1.00	86.77		O
  ATOM	10982	C5	NAG	J	1546	−21.399	−8.665	−42.371	1.00	87.12		C
  ATOM	10983	C6	NAG	J	1546	−21.176	−10.167	−42.218	1.00	87.02		C
  ATOM	10984	O6	NAG	J	1546	−20.698	−10.439	−40.920	1.00	86.44		O
  ATOM	10985	O5	NAG	J	1546	−20.211	−8.081	−42.842	1.00	85.80		O
  ATOM	10986	C1	NAG	J	1525	19.621	34.609	−15.280	1.00	72.96		C
  ATOM	10987	C2	NAG	J	1525	20.014	34.434	−16.749	1.00	83.63		C
  ATOM	10988	N2	NAG	J	1525	21.459	34.306	−16.817	1.00	85.81		N
  ATOM	10989	C7	NAG	J	1525	22.104	33.549	−17.705	1.00	87.77		C
  ATOM	10990	O7	NAG	J	1525	21.559	33.036	−18.682	1.00	89.34		O
  ATOM	10991	C8	NAG	J	1525	23.597	33.493	−17.560	1.00	86.84		C
  ATOM	10992	C3	NAG	J	1525	19.546	35.624	−17.590	1.00	85.86		C
  ATOM	10993	O3	NAG	J	1525	18.248	35.381	−18.082	1.00	84.14		O
  ATOM	10994	C4	NAG	J	1525	19.548	36.890	−16.742	1.00	88.88		C
  ATOM	10995	O4	NAG	J	1525	19.800	38.032	−17.545	1.00	96.14		O
  ATOM	10996	C5	NAG	J	1525	20.649	36.717	−15.706	1.00	85.57		C
  ATOM	10997	C6	NAG	J	1525	20.983	38.020	−14.991	1.00	85.54		C
  ATOM	10998	O6	NAG	J	1525	19.792	38.678	−14.623	1.00	85.75		O
  ATOM	10999	O5	NAG	J	1525	20.253	35.757	−14.753	1.00	79.39		O
  ATOM	11000	C1	NAG	J	1526	18.686	38.953	−17.492	1.00	101.26		C
  ATOM	11001	C2	NAG	J	1526	19.171	40.401	−17.403	1.00	103.37		C
  ATOM	11002	N2	NAG	J	1526	18.643	41.051	−16.216	1.00	104.36		N
  ATOM	11003	C7	NAG	J	1526	19.298	42.039	−15.609	1.00	104.07		C
  ATOM	11004	O7	NAG	J	1526	20.406	42.432	−15.972	1.00	103.82		O
  ATOM	11005	C8	NAG	J	1526	18.641	42.635	−14.399	1.00	103.07		C
  ATOM	11006	C3	NAG	J	1526	18.781	41.209	−18.636	1.00	104.12		C
  ATOM	11007	O3	NAG	J	1526	19.553	42.388	−18.684	1.00	103.63		O
  ATOM	11008	C4	NAG	J	1526	19.007	40.409	−19.911	1.00	104.68		C
  ATOM	11009	O4	NAG	J	1526	18.509	41.133	−21.014	1.00	105.46		O
  ATOM	11010	C5	NAG	J	1526	18.320	39.050	−19.846	1.00	104.39		C
  ATOM	11011	C6	NAG	J	1526	19.260	37.926	−20.265	1.00	104.32		C
  ATOM	11012	O6	NAG	J	1526	18.612	37.103	−21.209	1.00	104.22		O
  ATOM	11013	O5	NAG	J	1526	17.776	38.800	−18.564	1.00	103.22		O
  ATOM	11014	C1	NAG	K	1535	41.248	18.154	31.115	1.00	72.96		C
  ATOM	11015	C2	NAG	K	1535	41.855	19.316	30.338	1.00	83.63		C
  ATOM	11016	N2	NAG	K	1535	43.088	18.851	29.728	1.00	85.81		N
  ATOM	11017	C7	NAG	K	1535	43.469	19.184	28.498	1.00	87.77		C
  ATOM	11018	O7	NAG	K	1535	42.908	20.051	27.830	1.00	89.34		O
  ATOM	11019	C8	NAG	K	1535	44.735	18.550	28.004	1.00	86.84		C
  ATOM	11020	C3	NAG	K	1535	42.118	20.499	31.270	1.00	85.86		C
  ATOM	11021	O3	NAG	K	1535	40.974	21.322	31.315	1.00	84.14		O
  ATOM	11022	C4	NAG	K	1535	42.448	20.012	32.677	1.00	88.88		C
  ATOM	11023	O4	NAG	K	1535	43.310	20.930	33.331	1.00	96.14		O
  ATOM	11024	C5	NAG	K	1535	43.123	18.655	32.535	1.00	85.57		C
  ATOM	11025	C6	NAG	K	1535	43.778	18.188	33.832	1.00	85.54		C
  ATOM	11026	O6	NAG	K	1535	43.027	18.627	34.942	1.00	85.75		O
  ATOM	11027	O5	NAG	K	1535	42.190	17.694	32.074	1.00	79.39		O
  ATOM	11028	C1	NAG	K	1536	42.680	21.487	34.509	1.00	101.26		C
  ATOM	11029	C2	NAG	K	1536	43.698	21.677	35.636	1.00	103.37		C
  ATOM	11030	N2	NAG	K	1536	43.310	20.938	36.825	1.00	104.36		N
  ATOM	11031	C7	NAG	K	1536	44.214	20.505	37.702	1.00	104.07		C
  ATOM	11032	O7	NAG	K	1536	45.425	20.656	37.545	1.00	103.82		O
  ATOM	11033	C8	NAG	K	1536	43.689	19.781	38.906	1.00	103.07		C
  ATOM	11034	C3	NAG	K	1536	43.900	23.146	35.994	1.00	104.12		C
  ATOM	11035	O3	NAG	K	1536	45.102	23.286	36.719	1.00	103.63		O
  ATOM	11036	C4	NAG	K	1536	43.966	24.019	34.748	1.00	104.68		C
  ATOM	11037	O4	NAG	K	1536	43.988	25.378	35.126	1.00	105.46		O
  ATOM	11038	C5	NAG	K	1536	42.782	23.769	33.821	1.00	104.39		C
  ATOM	11039	C6	NAG	K	1536	43.229	23.554	32.380	1.00	104.32		C
  ATOM	11040	O6	NAG	K	1536	42.483	24.396	31.530	1.00	104.22		O
  ATOM	11041	O5	NAG	K	1536	41.980	22.692	34.267	1.00	103.22		O
  ATOM	11042	C1	NAG	K	1545	2.615	1.983	−49.407	1.00	56.85		C
  ATOM	11043	C2	NAG	K	1545	2.918	2.869	−50.621	1.00	66.44		C
  ATOM	11044	N2	NAG	K	1545	1.785	3.731	−50.894	1.00	69.47		N
  ATOM	11045	C7	NAG	K	1545	1.517	4.812	−50.168	1.00	72.43		C
  ATOM	11046	O7	NAG	K	1545	2.154	5.121	−49.163	1.00	73.31		O
  ATOM	11047	C8	NAG	K	1545	0.302	5.589	−50.579	1.00	72.22		C
  ATOM	11048	C3	NAG	K	1545	3.247	2.088	−51.890	1.00	68.81		C
  ATOM	11049	O3	NAG	K	1545	3.890	2.929	−52.817	1.00	68.22		O
  ATOM	11050	C4	NAG	K	1545	4.146	0.927	−51.513	1.00	71.19		C
  ATOM	11051	O4	NAG	K	1545	4.688	0.219	−52.606	1.00	76.87		O
  ATOM	11052	C5	NAG	K	1545	3.310	0.066	−50.596	1.00	67.79		C
  ATOM	11053	C6	NAG	K	1545	3.861	−1.348	−50.446	1.00	67.71		C
  ATOM	11054	O6	NAG	K	1545	4.940	−1.351	−49.538	1.00	67.33		O
  ATOM	11055	O5	NAG	K	1545	3.330	0.760	−49.372	1.00	62.66		O
  ATOM	11056	C1	NAG	K	1546	5.996	0.777	−52.858	1.00	83.18		C
  ATOM	11057	C2	NAG	K	1546	7.149	−0.188	−52.527	1.00	85.51		C
  ATOM	11058	N2	NAG	K	1546	7.911	0.336	−51.403	1.00	84.12		N
  ATOM	11059	C7	NAG	K	1546	8.044	−0.298	−50.234	1.00	82.64		C
  ATOM	11060	O7	NAG	K	1546	7.581	−1.414	−50.007	1.00	81.92		O
  ATOM	11061	C8	NAG	K	1546	8.880	0.392	−49.197	1.00	80.96		C
  ATOM	11062	C3	NAG	K	1546	8.093	−0.539	−53.684	1.00	87.47		C
  ATOM	11063	O3	NAG	K	1546	8.280	−1.934	−53.775	1.00	87.96		O
  ATOM	11064	C4	NAG	K	1546	7.594	0.007	−55.013	1.00	87.61		C
  ATOM	11065	O4	NAG	K	1546	8.586	−0.124	−56.008	1.00	86.77		O
  ATOM	11066	C5	NAG	K	1546	7.269	1.469	−54.777	1.00	87.12		C
  ATOM	11067	C6	NAG	K	1546	7.145	2.266	−56.074	1.00	87.02		C
  ATOM	11068	O6	NAG	K	1546	7.707	3.548	−55.896	1.00	86.44		O
  ATOM	11069	O5	NAG	K	1546	6.050	1.508	−54.073	1.00	85.80		O
  ATOM	11070	C1	NAG	K	1525	−29.090	1.326	0.431	1.00	56.85		C
  ATOM	11071	C2	NAG	K	1525	−30.509	1.450	1.026	1.00	66.44		C
  ATOM	11072	N2	NAG	K	1525	−30.921	0.195	1.623	1.00	69.47		N
  ATOM	11073	C7	NAG	K	1525	−30.381	−0.257	2.752	1.00	72.43		C
  ATOM	11074	O7	NAG	K	1525	−29.481	0.332	3.347	1.00	73.31		O
  ATOM	11075	C8	NAG	K	1525	−30.965	−1.518	3.317	1.00	72.22		C
  ATOM	11076	C3	NAG	K	1525	−31.621	1.959	0.102	1.00	68.81		C
  ATOM	11077	O3	NAG	K	1525	−32.692	2.482	0.855	1.00	68.22		O
  ATOM	11078	C4	NAG	K	1525	−31.056	3.022	−0.817	1.00	71.19		C
  ATOM	11079	O4	NAG	K	1525	−32.040	3.689	−1.591	1.00	76.87		O
  ATOM	11080	C5	NAG	K	1525	−30.031	2.269	−1.642	1.00	67.79		C
  ATOM	11081	C6	NAG	K	1525	−29.635	3.028	−2.906	1.00	67.71		C
  ATOM	11082	O6	NAG	K	1525	−28.857	4.152	−2.561	1.00	67.33		O
  ATOM	11083	O5	NAG	K	1525	−28.906	2.013	−0.814	1.00	62.66		O
  ATOM	11084	C1	NAG	K	1526	−32.430	4.903	−0.902	1.00	83.18		C
  ATOM	11085	C2	NAG	K	1526	−31.984	6.181	−1.635	1.00	85.51		C
  ATOM	11086	N2	NAG	K	1526	−30.942	6.832	−0.859	1.00	84.12		N
  ATOM	11087	C7	NAG	K	1526	−29.678	6.943	−1.267	1.00	82.64		C
  ATOM	11088	O7	NAG	K	1526	−29.276	6.528	−2.353	1.00	81.92		O
  ATOM	11089	C8	NAG	K	1526	−28.739	7.632	−0.321	1.00	80.96		C
  ATOM	11090	C3	NAG	K	1526	−33.070	7.210	−1.965	1.00	87.47		C
  ATOM	11091	O3	NAG	K	1526	−32.990	7.586	−3.320	1.00	87.96		O
  ATOM	11092	C4	NAG	K	1526	−34.468	6.712	−1.644	1.00	87.61		C
  ATOM	11093	O4	NAG	K	1526	−35.385	7.783	−1.653	1.00	86.77		O
  ATOM	11094	C5	NAG	K	1526	−34.395	6.107	−0.257	1.00	87.12		C
  ATOM	11095	C6	NAG	K	1526	−35.779	5.918	0.354	1.00	87.02		C
  ATOM	11096	O6	NAG	K	1526	−35.724	6.194	1.736	1.00	86.44		O
  ATOM	11097	O5	NAG	K	1526	−33.754	4.862	−0.395	1.00	85.80		O
  ATOM	11098	C1	NAG	L	1535	−2.070	11.341	45.870	1.00	72.96		C
  ATOM	11099	C2	NAG	L	1535	−3.565	11.622	45.740	1.00	83.63		C
  ATOM	11100	N2	NAG	L	1535	−3.793	13.060	45.821	1.00	85.81		N
  ATOM	11101	C7	NAG	L	1535	−4.706	13.721	45.104	1.00	87.77		C
  ATOM	11102	O7	NAG	L	1535	−5.570	13.168	44.424	1.00	89.34		O
  ATOM	11103	C8	NAG	L	1535	−4.727	15.213	45.270	1.00	86.84		C
  ATOM	11104	C3	NAG	L	1535	−4.303	10.883	46.855	1.00	85.86		C
  ATOM	11105	O3	NAG	L	1535	−4.575	9.563	46.441	1.00	84.14		O
  ATOM	11106	C4	NAG	L	1535	−3.441	10.862	48.115	1.00	88.88		C
  ATOM	11107	O4	NAG	L	1535	−4.260	10.849	49.273	1.00	96.14		O
  ATOM	11108	C5	NAG	L	1535	−2.549	12.100	48.077	1.00	85.57		C
  ATOM	11109	C6	NAG	L	1535	−1.872	12.404	49.410	1.00	85.54		C
  ATOM	11110	O6	NAG	L	1535	−1.282	11.235	49.931	1.00	85.75		O
  ATOM	11111	O5	NAG	L	1535	−1.585	11.956	47.052	1.00	79.39		O
  ATOM	11112	C1	NAG	L	1536	−4.061	9.626	50.020	1.00	101.26		C
  ATOM	11113	C2	NAG	L	1536	−4.102	9.893	51.524	1.00	103.37		C
  ATOM	11114	N2	NAG	L	1536	−2.863	9.461	52.140	1.00	104.36		N
  ATOM	11115	C7	NAG	L	1536	−2.405	10.023	53.252	1.00	104.07		C
  ATOM	11116	O7	NAG	L	1536	−2.958	10.972	53.807	1.00	103.82		O
  ATOM	11117	C8	NAG	L	1536	−1.111	9.476	53.773	1.00	103.07		C
  ATOM	11118	C3	NAG	L	1536	−5.265	9.179	52.199	1.00	104.12		C
  ATOM	11119	O3	NAG	L	1536	−5.486	9.747	53.470	1.00	103.63		O
  ATOM	11120	C4	NAG	L	1536	−6.532	9.306	51.370	1.00	104.68		C
  ATOM	11121	O4	NAG	L	1536	−7.534	8.514	51.963	1.00	105.46		O
  ATOM	11122	C5	NAG	L	1536	−6.309	8.841	49.937	1.00	104.39		C
  ATOM	11123	C6	NAG	L	1536	−6.864	9.838	48.932	1.00	104.32		C
  ATOM	11124	O6	NAG	L	1536	−7.576	9.132	47.943	1.00	104.22		O
  ATOM	11125	O5	NAG	L	1536	−4.947	8.581	49.669	1.00	103.22		O
  ATOM	11126	C1	NAG	L	1545	−11.652	16.132	−42.376	1.00	56.85		C
  ATOM	11127	C2	NAG	L	1545	−11.811	17.208	−43.449	1.00	66.44		C
  ATOM	11128	N2	NAG	L	1545	−10.485	17.531	−43.934	1.00	69.47		N
  ATOM	11129	C7	NAG	L	1545	−9.803	16.702	−44.718	1.00	72.43		C
  ATOM	11130	O7	NAG	L	1545	−10.291	15.689	−45.219	1.00	73.31		O
  ATOM	11131	C8	NAG	L	1545	−8.341	16.997	−44.865	1.00	72.22		C
  ATOM	11132	C3	NAG	L	1545	−12.475	18.463	−42.898	1.00	68.81		C
  ATOM	11133	O3	NAG	L	1545	−12.890	19.301	−43.953	1.00	68.22		O
  ATOM	11134	C4	NAG	L	1545	−13.667	18.017	−42.071	1.00	71.19		C
  ATOM	11135	O4	NAG	L	1545	−14.509	19.077	−41.672	1.00	76.87		O
  ATOM	11136	C5	NAG	L	1545	−13.113	17.218	−40.907	1.00	67.79		C
  ATOM	11137	C6	NAG	L	1545	−14.125	17.020	−39.786	1.00	67.71		C
  ATOM	11138	O6	NAG	L	1545	−15.086	16.069	−40.180	1.00	67.33		O
  ATOM	11139	O5	NAG	L	1545	−12.727	15.986	−41.467	1.00	62.66		O
  ATOM	11140	C1	NAG	L	1546	−15.574	19.184	−42.644	1.00	83.18		C
  ATOM	11141	C2	NAG	L	1546	−16.945	18.806	−42.055	1.00	85.51		C
  ATOM	11142	N2	NAG	L	1546	−17.436	17.613	−42.723	1.00	84.12		N
  ATOM	11143	C7	NAG	L	1546	−17.522	16.433	−42.114	1.00	82.64		C
  ATOM	11144	O7	NAG	L	1546	−17.214	16.256	−40.937	1.00	81.92		O
  ATOM	11145	C8	NAG	L	1546	−18.068	15.302	−42.933	1.00	80.96		C
  ATOM	11146	C3	NAG	L	1546	−18.033	19.883	−42.093	1.00	87.47		C
  ATOM	11147	O3	NAG	L	1546	−18.679	19.995	−40.846	1.00	87.96		O
  ATOM	11148	C4	NAG	L	1546	−17.484	21.228	−42.533	1.00	87.61		C
  ATOM	11149	O4	NAG	L	1546	−18.538	22.132	−42.784	1.00	86.77		O
  ATOM	11150	C5	NAG	L	1546	−16.723	20.935	−43.810	1.00	87.12		C
  ATOM	11151	C6	NAG	L	1546	−16.525	22.183	−44.663	1.00	87.02		C
  ATOM	11152	O6	NAG	L	1546	−17.041	21.939	−45.954	1.00	86.44		O
  ATOM	11153	O5	NAG	L	1546	−15.492	20.356	−43.444	1.00	85.80		O
  ATOM	11154	C1	NAG	L	1525	21.793	−26.723	−18.244	1.00	56.85		C
  ATOM	11155	C2	NAG	L	1525	22.365	−27.060	−19.634	1.00	66.44		C
  ATOM	11156	N2	NAG	L	1525	22.402	−25.862	−20.460	1.00	69.47		N
  ATOM	11157	C7	NAG	L	1525	23.351	−24.934	−20.342	1.00	72.43		C
  ATOM	11158	O7	NAG	L	1525	24.279	−25.026	−19.540	1.00	73.31		O
  ATOM	11159	C8	NAG	L	1525	23.280	−23.766	−21.282	1.00	72.22		C
  ATOM	11160	C3	NAG	L	1525	21.624	−28.181	−20.369	1.00	68.81		C
  ATOM	11161	O3	NAG	L	1525	22.407	−28.687	−21.427	1.00	68.22		O
  ATOM	11162	C4	NAG	L	1525	21.308	−29.275	−19.364	1.00	71.19		C
  ATOM	11163	O4	NAG	L	1525	20.761	−30.454	−19.918	1.00	76.87		O
  ATOM	11164	C5	NAG	L	1525	20.389	−28.631	−18.348	1.00	67.79		C
  ATOM	11165	C6	NAG	L	1525	19.627	−29.660	−17.520	1.00	67.71		C
  ATOM	11166	O6	NAG	L	1525	20.442	−30.144	−16.478	1.00	67.33		O
  ATOM	11167	O5	NAG	L	1525	21.225	−27.824	−17.551	1.00	62.66		O
  ATOM	11168	C1	NAG	L	1526	21.846	−31.384	−20.124	1.00	83.18		C
  ATOM	11169	C2	NAG	L	1526	21.792	−32.604	−19.182	1.00	85.51		C
  ATOM	11170	N2	NAG	L	1526	22.928	−32.540	−18.274	1.00	84.12		N
  ATOM	11171	C7	NAG	L	1526	22.851	−32.639	−16.945	1.00	82.64		C
  ATOM	11172	O7	NAG	L	1526	21.797	−32.785	−16.328	1.00	81.92		O
  ATOM	11173	C8	NAG	L	1526	24.156	−32.563	−16.207	1.00	80.96		C
  ATOM	11174	C3	NAG	L	1526	21.773	−33.981	−19.854	1.00	87.47		C
  ATOM	11175	O3	NAG	L	1526	20.751	−34.790	−19.316	1.00	87.96		O
  ATOM	11176	C4	NAG	L	1526	21.648	−33.901	−21.365	1.00	87.61		C
  ATOM	11177	O4	NAG	L	1526	21.965	−35.150	−21.938	1.00	86.77		O
  ATOM	11178	C5	NAG	L	1526	22.647	−32.860	−21.827	1.00	87.12		C
  ATOM	11179	C6	NAG	L	1526	22.903	−32.944	−23.327	1.00	87.02		C
  ATOM	11180	O6	NAG	L	1526	24.294	−32.969	−23.563	1.00	86.44		O
  ATOM	11181	O5	NAG	L	1526	22.108	−31.604	−21.499	1.00	85.80		O
  END

Claims (30)

1. A pre-fusion respiratory syncytial virus (RSV) F polypeptide comprising at least two introduced cysteine residues, wherein said cysteines are in close proximity to one another and form an intrachain disulfide bond that stabilizes the pre-fusion RSV F polypeptide.

2. The pre-fusion RSV F polypeptide ofclaim 1, wherein said cysteine mutations are not more than about 10 Å away from each other.

3. The pre-fusion RSV F polypeptide ofclaim 1, wherein:

the HRB region and the DI and/or DII region contain an introduced cysteine residue, and a disulfide bond is formed between the introduced cysteine residue in the HRB region and the introduced cysteine residue in the DI or DII region;

(ii) the HRA region and the DIII region contain an introduced cysteine residue, and a disulfide bond is formed between the introduced cysteine residues in the HRA region and the DIII region; or

(iii) the HRA region contains at least two introduced cysteine residues, and a disulfide bond is formed between the introduced cysteine residues in the HRA region.

4. (canceled)

5. (canceled)

6. A pre-fusion respiratory syncytial virus (RSV) F polypeptide comprising a post-fusion modification selected from the group consisting of deletion of the HRA helix, deletion of the HRB helix, introduction of point mutations, addition of glycosylation sites and combinations thereof, wherein said post-fusion modification destabilizes the post-fusion conformation.

7. The pre-fusion RSV F polypeptide ofclaim 6, wherein said destabilizing post-fusion modification is deletion of the HRB helix.

8. The pre-fusion RSV F polypeptide ofclaim 7, further comprising deletion of the fusion peptide.

9. The pre-fusion RSV F polypeptide ofclaim 6, wherein said destabilizing post-fusion modification is addition of a glycosylation site.

10. (canceled)

11. (canceled)

12. The pre-fusion RSV F polypeptide ofclaim 1, wherein the pre-fusion RSV F polypeptide is a soluble ectodomain of RSV F or a trimer of soluble ectodomain of RSV F.

13. A chimeric pre-fusion F protein comprising a stabilized F protein from a virus other than RSV that contains one or more neutralizing epitope of RSV F.

14. The chimeric pre-fusion F protein ofclaim 13, wherein said stabilized F protein is:

from a parainfluenza virus F polypeptide or a metapneumovirus virus F polypeptide;

(ii) a PIV5 pre-fusion F polypeptide or a NDV pre-fusion F polypeptide; or

(iii) a soluble ectodomain.

15. (canceled)

16. (canceled)

17. The chimeric pre-fusion F protein ofclaim 13, wherein said neutralizing epitopes of RSV F are from the HRA region of RSV F.

18. The chimeric pre-fusion F protein ofclaim 13, wherein the neutralizing epitopes are selected from the group consisting of the epitopes that are recognized by motavizumab, palivizumab, mAb 11, mAb 151, mAb 1129, mAb 1153, mAb 1200, mAb 1214, mAb 1237, mAb 47F, mAb 7C2, mAb B4, Fab 19, mAb AK13A2, mAb 7.936, mAb 9.936, mAb 19, mAb 20, mAb 101F and combinations thereof.

19. The pre-fusion RSV F polypeptide ofclaim 1, further comprising a heterologous oligomerization domain, an epitope, or a signal peptide.

20. The pre-fusion RSV F polypeptide ofclaim 19, wherein said heterologous oligomerization domain is a trimerization domain.

21. The pre-fusion RSV F polypeptide ofclaim 20 wherein the trimerization domain is from influenza hemagglutinin, SARS spike, HIV gp41, NadA, modified GCN4, GCN4 or ATCase.

22. An immunogenic composition comprising the pre-fusion RSV F polypeptide ofclaims 1.

23. The immunogenic composition ofclaim 22, wherein said composition further comprises an adjuvant.

24. The immunogenic composition ofclaim 23, wherein the adjuvant is selected from the group consisting of: an aluminum salt, a squalene-in-water emulsion, a benzonaphthyridine compound, a phospholipid compound, a small molecule immunopotentiator and combinations of any of the foregoing.

25. An isolated nucleic acid encoding the pre-fusion RSV F polypeptide ofclaim 1.

26. The isolated nucleic acid ofclaim 25, which is a self-replicating RNA molecule.

27. An immunogenic composition comprising the self-replicating RNA molecule ofclaim 26.

28. The immunogenic composition ofclaim 27, further comprising an RNA delivery system.

29. A method of inducing an immune response to RSV F in a subject comprising administering an immunogenic composition ofclaim 22 to the subject.

30. A method of inducing an immune response to RSV F in a subject comprising administering an immunogenic composition ofclaim 27 to the subject.

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