US20110178463A1 - Cartridge interface assembly with driving plunger - Google Patents
Cartridge interface assembly with driving plungerDownload PDFInfo
- Publication number
- US20110178463A1 US20110178463A1US12/689,250US68925010AUS2011178463A1US 20110178463 A1US20110178463 A1US 20110178463A1US 68925010 AUS68925010 AUS 68925010AUS 2011178463 A1US2011178463 A1US 2011178463A1
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- US
- United States
- Prior art keywords
- cartridge
- plunger
- driving plunger
- driver
- interface assembly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
- A61M5/14566—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir for receiving a piston rod of the pump
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M5/2422—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
- A61M5/2425—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by compression of deformable ampoule or carpule wall
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M2005/14506—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons mechanically driven, e.g. spring or clockwork
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
- A61M5/1456—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir
Definitions
- the present inventiongenerally relates to external drug pumps, and particularly to an assembly for pushing a drug from a cartridge, in which the assembly interfaces between an actuator, e.g., a motor, and a pushing device, e.g., a plunger in the cartridge.
- an actuatore.g., a motor
- a pushing devicee.g., a plunger in the cartridge.
- External drug pumpsare typically used to deliver to patients substances which contain large molecules which cannot be digested when administered orally, such as insulin, biogenic drugs or protein drugs among others.
- the pumpis adhered to the abdomen or chest of the patient and delivers the substance to the patient via a cannula or needle that is inserted into the patient's skin.
- PCT Patent Application PCT/IL2008/001312(published as WO 2009/044401) to Gross and Cabiri (as well as U.S. patent applications Ser. Nos. 12/244,666 and 12/244,668, the disclosures of which are incorporated herein by reference), describes an external drug pump.
- a vialis provided that contains a substance to be administered to a subject.
- drugand “substance” are used interchangeably throughout the specification and claims, and encompass any material administered to a subject.
- carrierthroughout the specification and claims encompasses any container for a drug, such as but not limited to, a cartridge, vial, syringe, bottle, ampoule and many more, and is not limited to any size or shape.
- the cartridgeis sealed by a stopper, and has first and second threaded elements (e.g., a screw and a nut) that are threadedly coupled to each other.
- the distal end of the second threaded elementdefines a coupling portion that couples the second threaded element to the stopper.
- the first threaded elementis rotatable with respect to the cartridge, and is linearly immobile with respect to the cartridge during rotation of the first threaded element.
- the first threaded elementrotated by a motor, is configured to linearly advance the stopper and at least the distal end of the second threaded element toward the distal end of the cartridge, without substantially rotating the second threaded element and the stopper.
- FIG. 1illustrates the relevant elements of the prior art cartridge assembly of WO 2009/044401 (based on FIG. 4 of that application), wherein a cartridge 22 is inserted into a housing base.
- cartridge 22is inserted into a cartridge piercing mechanism 44 , which pierces a seal at the distal end of cartridge 22 having a stopper 24 therein (the stopper being an example of a plunger, piston or pushing device; the stopper will also be referred to as a plunger).
- Cartridge 22is then lowered into the housing base.
- opposing resilient arms 70support the cartridge upon the housing base.
- a first cog 52engages a second cog 54 .
- First cog 52is rotated by the motor, not shown here.
- first threaded element 26protrudes a distance h from the proximal end of the cartridge.
- the proximal end of the first threaded element(or of second cog 54 ) comprises a rounded portion 74 .
- Portion 34 of the housing basecomprises an angled face 76 .
- the motor(not shown) turns cog 52 , which turns cog 54 . This linearly advances stopper 24 towards the distal end of the cartridge 22 , thereby administering the substance from cartridge 22 .
- FIG. 2illustrates cartridge 22 with plunger 24 in an initial position before cartridge 22 has been filled.
- the cartridgeis either pre-filled by the manufacturer or filled by the user, such as with a hypodermic needle 15 inserted through a septum 17 in cartridge 22 ( FIG. 3 ) or through a septum 19 in the housing of the drug pump ( FIG. 4 ).
- the plunger 24moves linearly in the cartridge 22 as the cartridge is filled. Because no two cartridges will be filled with exactly the same amount of substance, such as due to tolerances, different injected volumes, different diameters or other dimensions, different plunger shapes, air bubbles or other factors, there is unfortunately no definitive position of the plunger 24 after cartridge 22 has been filled.
- the present inventionseeks to provide an improved assembly for pushing a drug from a cartridge, in which the assembly interfaces between an actuator, e.g., a motor, and a pushing device, e.g., a plunger in the cartridge, as is described more in detail hereinbelow.
- an actuatore.g., a motor
- a pushing devicee.g., a plunger in the cartridge
- a cartridge interface assemblyincluding a driving plunger including an outer shaft, and a driver including an inner shaft, the inner shaft mating with an intermediate shaft, the intermediate shaft mating with the outer shaft, so that the shafts are movable telescopically with respect to one another, wherein rotation of the driver causes the driving plunger to advance in a direction away from the driver.
- the drivermay include a gear wheel.
- the inner shaftis threadedly received inside a hollow portion of the intermediate shaft, and the intermediate shaft is threadedly received inside a hollow portion of the outer shaft.
- the cartridge interface assemblyis inserted in a cartridge in which a plunger is slidingly disposed, and rotation of the driver causes the driving plunger to advance distally in the cartridge until abutting the plunger.
- a method for interfacing between a driver and a plunger slidingly disposed in a cartridgeincluding inserting a cartridge interface assembly in the cartridge, the cartridge interface assembly including a driving plunger including an outer shaft, and a driver including an inner shaft, the inner shaft mating with an intermediate shaft, the intermediate shaft mating with the outer shaft, so that the shafts are movable telescopically with respect to one another, and rotating the driver to cause the driving plunger to advance distally in the cartridge until abutting the plunger.
- FIG. 1is a simplified illustration of a prior art cartridge assembly
- FIG. 2is a simplified illustration of the prior art cartridge with plunger in an initial position before the cartridge has been filled;
- FIG. 3is a simplified illustration of filling the prior art cartridge with a hypodermic needle inserted through a septum in the cartridge;
- FIG. 4is a simplified illustration of filling the prior art cartridge with a hypodermic needle inserted through a septum in a housing of a drug pump;
- FIGS. 5 and 6are simplified pictorial and sectional illustrations, respectively, of a cartridge interface assembly including a driving plunger, constructed and operative in accordance with an embodiment of the present invention.
- FIGS. 7 and 8are simplified illustrations of the cartridge interface assembly inserted in a cartridge, respectively before and after the driving plunger abuts against the plunger of the cartridge, in accordance with an embodiment of the present invention.
- FIGS. 5 and 6illustrate a cartridge interface assembly 80 , constructed and operative in accordance with a non-limiting embodiment of the present invention.
- Cartridge interface assembly 80includes a driving plunger 82 at the distal end of an outer shaft 84 .
- a driver 86such as but not limited to, a gear wheel, includes an inner shaft 88 .
- Inner shaft 88is received inside a hollow portion of an intermediate shaft 90 and threadedly mates therewith.
- Intermediate shaft 90is in turn received inside a hollow portion of outer shaft 84 and threadedly mates therewith.
- the shafts 84 , 88 and 90are arranged to move telescopically with respect to one another.
- Outer shaft 84may further include a proximal O-ring 92 .
- the driving plunger 82 and O-ring 92are preferably made of an elastomer, such as natural or synthetic rubber. The other parts may be made of plastic or metal.
- FIG. 7illustrates the cartridge interface assembly 80 inserted in cartridge 22 .
- Driving plunger 82is initially distanced somewhat from plunger 24 of cartridge 22 .
- Rotation of driver 86causes inner shaft 88 to rotate, which causes intermediate shaft 90 to rotate and advance linearly towards the distal end of cartridge interface assembly 80 , that is, in the direction towards driving plunger 82 as indicated by arrow 91 .
- the distal movement of intermediate shaft 90in turn causes outer shaft 84 to advance distally together with driving plunger 82 .
- the friction of driving plunger 82 against the inner wall of cartridge 22is such that it is much easier for driving plunger 82 to move linearly than to rotate, such that the rotation of inner shaft 88 and intermediate shaft 90 cause driving plunger 82 to advance distally in cartridge 22 until driving plunger 82 abuts against plunger 24 as shown in FIG. 8 .
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- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Description
- The present invention generally relates to external drug pumps, and particularly to an assembly for pushing a drug from a cartridge, in which the assembly interfaces between an actuator, e.g., a motor, and a pushing device, e.g., a plunger in the cartridge.
- External drug pumps are typically used to deliver to patients substances which contain large molecules which cannot be digested when administered orally, such as insulin, biogenic drugs or protein drugs among others. Typically, the pump is adhered to the abdomen or chest of the patient and delivers the substance to the patient via a cannula or needle that is inserted into the patient's skin.
- PCT Patent Application PCT/IL2008/001312 (published as WO 2009/044401) to Gross and Cabiri (as well as U.S. patent applications Ser. Nos. 12/244,666 and 12/244,668, the disclosures of which are incorporated herein by reference), describes an external drug pump. In this pump, a vial is provided that contains a substance to be administered to a subject. (The terms “drug” and “substance” are used interchangeably throughout the specification and claims, and encompass any material administered to a subject. The term “cartridge” throughout the specification and claims encompasses any container for a drug, such as but not limited to, a cartridge, vial, syringe, bottle, ampoule and many more, and is not limited to any size or shape.)
- The cartridge is sealed by a stopper, and has first and second threaded elements (e.g., a screw and a nut) that are threadedly coupled to each other. The distal end of the second threaded element defines a coupling portion that couples the second threaded element to the stopper. The first threaded element is rotatable with respect to the cartridge, and is linearly immobile with respect to the cartridge during rotation of the first threaded element. The first threaded element, rotated by a motor, is configured to linearly advance the stopper and at least the distal end of the second threaded element toward the distal end of the cartridge, without substantially rotating the second threaded element and the stopper.
- The following is provided to facilitate understanding of the above described assembly.
- Reference is made to
FIG. 1 , which illustrates the relevant elements of the prior art cartridge assembly of WO 2009/044401 (based onFIG. 4 of that application), wherein acartridge 22 is inserted into a housing base. - The distal end of
cartridge 22 is inserted into a cartridge piercing mechanism44, which pierces a seal at the distal end ofcartridge 22 having astopper 24 therein (the stopper being an example of a plunger, piston or pushing device; the stopper will also be referred to as a plunger). Cartridge22 is then lowered into the housing base. Typically, opposingresilient arms 70 support the cartridge upon the housing base. Ascartridge 22 is lowered into the housing base, a first cog52 engages a second cog54. (First cog52 is rotated by the motor, not shown here.) In some applications, before insertion ofcartridge 22 into the housing, first threaded element26 protrudes a distance h from the proximal end of the cartridge. The proximal end of the first threaded element (or of second cog54) comprises a rounded portion74.Portion 34 of the housing base comprises anangled face 76. As rounded portion74 slides past the angled face, the first threaded element is pushed the distance h inside the cartridge. As a result, the first and second threaded elements26 and28 and thestopper 24 are displaced towards the distal end of thecartridge 22. During operation, the motor (not shown) turns cog52, which turns cog54. This linearly advances stopper24 towards the distal end of thecartridge 22, thereby administering the substance fromcartridge 22. - Reference is now made to
FIG. 2 , which illustratescartridge 22 withplunger 24 in an initial position beforecartridge 22 has been filled. The cartridge is either pre-filled by the manufacturer or filled by the user, such as with ahypodermic needle 15 inserted through aseptum 17 in cartridge22 (FIG. 3 ) or through aseptum 19 in the housing of the drug pump (FIG. 4 ). As shown inFIG. 3 , theplunger 24 moves linearly in thecartridge 22 as the cartridge is filled. Because no two cartridges will be filled with exactly the same amount of substance, such as due to tolerances, different injected volumes, different diameters or other dimensions, different plunger shapes, air bubbles or other factors, there is unfortunately no definitive position of theplunger 24 aftercartridge 22 has been filled. This can cause a problem because it is possible that the overall length of the geared and threaded mechanism (which is predefined) that interfaces withplunger 24 may not meet the filled position of plunger24 (which is unknown), thereby causing a problem to properly push againstplunger 24 in order to administer the substance. - The present invention seeks to provide an improved assembly for pushing a drug from a cartridge, in which the assembly interfaces between an actuator, e.g., a motor, and a pushing device, e.g., a plunger in the cartridge, as is described more in detail hereinbelow. The invention solves the above mentioned problem of the prior art. Although the invention is described with reference to PCT Patent Application WO 2009/044401, nevertheless it is understood that the invention is applicable for many types of motor-driven drug cartridges.
- There is thus provided in accordance with an embodiment of the present invention a cartridge interface assembly including a driving plunger including an outer shaft, and a driver including an inner shaft, the inner shaft mating with an intermediate shaft, the intermediate shaft mating with the outer shaft, so that the shafts are movable telescopically with respect to one another, wherein rotation of the driver causes the driving plunger to advance in a direction away from the driver. The driver may include a gear wheel.
- In accordance with a non-limiting embodiment of the present invention the inner shaft is threadedly received inside a hollow portion of the intermediate shaft, and the intermediate shaft is threadedly received inside a hollow portion of the outer shaft.
- In accordance with an embodiment of the present invention the cartridge interface assembly is inserted in a cartridge in which a plunger is slidingly disposed, and rotation of the driver causes the driving plunger to advance distally in the cartridge until abutting the plunger.
- There is also provided in accordance with an embodiment of the present invention a method for interfacing between a driver and a plunger slidingly disposed in a cartridge, the method including inserting a cartridge interface assembly in the cartridge, the cartridge interface assembly including a driving plunger including an outer shaft, and a driver including an inner shaft, the inner shaft mating with an intermediate shaft, the intermediate shaft mating with the outer shaft, so that the shafts are movable telescopically with respect to one another, and rotating the driver to cause the driving plunger to advance distally in the cartridge until abutting the plunger.
- The present invention will be understood and appreciated more fully from the following detailed description taken in conjunction with the drawings in which:
FIG. 1 is a simplified illustration of a prior art cartridge assembly;FIG. 2 is a simplified illustration of the prior art cartridge with plunger in an initial position before the cartridge has been filled;FIG. 3 is a simplified illustration of filling the prior art cartridge with a hypodermic needle inserted through a septum in the cartridge;FIG. 4 is a simplified illustration of filling the prior art cartridge with a hypodermic needle inserted through a septum in a housing of a drug pump;FIGS. 5 and 6 are simplified pictorial and sectional illustrations, respectively, of a cartridge interface assembly including a driving plunger, constructed and operative in accordance with an embodiment of the present invention; andFIGS. 7 and 8 are simplified illustrations of the cartridge interface assembly inserted in a cartridge, respectively before and after the driving plunger abuts against the plunger of the cartridge, in accordance with an embodiment of the present invention.- Reference is now made to
FIGS. 5 and 6 , which illustrate acartridge interface assembly 80, constructed and operative in accordance with a non-limiting embodiment of the present invention. Cartridge interface assembly 80 includes adriving plunger 82 at the distal end of anouter shaft 84. Adriver 86, such as but not limited to, a gear wheel, includes aninner shaft 88.Inner shaft 88 is received inside a hollow portion of anintermediate shaft 90 and threadedly mates therewith.Intermediate shaft 90 is in turn received inside a hollow portion ofouter shaft 84 and threadedly mates therewith. Theshafts Outer shaft 84 may further include a proximal O-ring 92. The drivingplunger 82 and O-ring92 are preferably made of an elastomer, such as natural or synthetic rubber. The other parts may be made of plastic or metal.- Reference is now made to
FIG. 7 , which illustrates thecartridge interface assembly 80 inserted incartridge 22.Driving plunger 82 is initially distanced somewhat fromplunger 24 ofcartridge 22. Rotation of driver86 (such as by meshing with a rotating motor not shown) causesinner shaft 88 to rotate, which causesintermediate shaft 90 to rotate and advance linearly towards the distal end ofcartridge interface assembly 80, that is, in the direction towards drivingplunger 82 as indicated byarrow 91. The distal movement ofintermediate shaft 90 in turn causesouter shaft 84 to advance distally together with drivingplunger 82. The friction of driving plunger82 against the inner wall ofcartridge 22 is such that it is much easier for drivingplunger 82 to move linearly than to rotate, such that the rotation ofinner shaft 88 andintermediate shaft 90 cause drivingplunger 82 to advance distally incartridge 22 until drivingplunger 82 abuts againstplunger 24 as shown inFIG. 8 . - Thus, with the present invention, no matter what the final position of
plunger 24 is after fillingcartridge 22 with the substance to be administered, the driving mechanism for pushingplunger 24 will always properly contactplunger 24 viacartridge interface assembly 80 due to the distance compensating action ofcartridge interface assembly 80. - It will be appreciated by persons skilled in the art that the present invention is not limited by what has been particularly shown and described hereinabove. Rather the scope of the present invention includes both combinations and subcombinations of the features described hereinabove as well as modifications and variations thereof which would occur to a person of skill in the art upon reading the foregoing description and which are not in the prior art.
Claims (3)
1. A combination cartridge and cartridge interface assembly comprising:
a rotationally immobile cartridge having an inner cylindrical surface, a first stopper slidingly inserted in the cartridge, a distal end and a substance therein for administration to a subject;
a driving plunger comprising an outer shaft; and
a driver comprising an inner shaft, said inner shaft mating with said outer shaft, so that said shafts are movable telescopically with respect to one another, wherein rotation of said driver causes said driving plunger to linearly advance in a direction away from said driver, the arrangement being such that on insertion of the cartridge interface assembly in the rotationally immobile cartridge, the driving plunger is in complementary sealing anti-rotation friction relation with the inner cylindrical surface such that rotation of said driver causes said driving plunger to linearly advance only towards the distal end until the driving plunger abuts against the stopper whereupon the driving lunger urges the stopper towards the distal end for metering substance from the cartridge.
7. A method for interfacing between a driver and plunger slidingly disposed in a rotationally immobile cartridge, the method comprising:
providing a a rotationally immobile cartridge having an inner cylindrical surface, a first stopper slidingly inserted in the cartridge, a distal end and a substance therein for administration to a subject
inserting a cartridge interface assembly in the rotationally immobile cartridge, said cartridge interface assembly comprising a driving plunger comprising an outer shaft, and a driver comprising an inner shaft, said inner shaft mating with said outer shaft, so that said shafts are moveable telescopically with respect to one another; and
rotating said driver to cause said driving plunger to linearly advance distally in said cartridge until abutting said plunger, the arrangement being such that on insertion of the cartridge interface assembly in the rotationally immobile cartridge, the driving plunger is in complementary sealing anti-rotation friction relation with the inner cylindrical surface such that rotation of said driver causes said driving plunger to linearly advance only towards the distal end until the driving plunger abuts against the stopper whereupon the driving plunger urges the stopper towards the distal end for metering substance from the cartridge.
8. The combination as recited inclaim 1 , wherein said complementary sealing anti-rotation friction relation is the only force impeding rotation of the driving plunger with respect to the cartridge.
Priority Applications (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/689,250US7967795B1 (en) | 2010-01-19 | 2010-01-19 | Cartridge interface assembly with driving plunger |
| EP11707942.6AEP2525846B1 (en) | 2010-01-19 | 2011-01-19 | Cartridge interface assembly |
| EP14171477.4AEP2774637B1 (en) | 2010-01-19 | 2011-01-19 | Cartridge interface assembly |
| BR112012017839ABR112012017839B1 (en) | 2010-01-19 | 2011-01-19 | combination of cartridge and cartridge interface assembly and method for interfacing between a driver and a piston slidably arranged in a cartridge |
| CN201180006571.0ACN102883761B (en) | 2010-01-19 | 2011-01-19 | Combinations of cartridges and cartridge connection assemblies and related methods |
| PCT/US2011/021605WO2011090956A2 (en) | 2010-01-19 | 2011-01-19 | Cartridge interface assembly |
| CN201410289204.1ACN104069563B (en) | 2010-01-19 | 2011-01-19 | Cylinder connects assembly |
| BR122019022494-3ABR122019022494B1 (en) | 2010-01-19 | 2011-01-19 | cartridge interface set |
| US13/521,181US9259532B2 (en) | 2010-01-19 | 2011-01-19 | Cartridge interface assembly |
| JP2012550069AJP5856077B2 (en) | 2010-01-19 | 2011-01-19 | Cartridge coupling mechanism |
| US13/874,017US9656019B2 (en) | 2007-10-02 | 2013-04-30 | Apparatuses for securing components of a drug delivery system during transport and methods of using same |
| US13/874,085US9345836B2 (en) | 2007-10-02 | 2013-04-30 | Disengagement resistant telescoping assembly and unidirectional method of assembly for such |
| US14/880,673US20160030665A1 (en) | 2010-01-19 | 2015-10-12 | Cartridge interface assembly |
| US15/461,727US10960131B2 (en) | 2007-10-02 | 2017-03-17 | Apparatuses for securing components of a drug delivery system during transport and methods of using same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/689,250US7967795B1 (en) | 2010-01-19 | 2010-01-19 | Cartridge interface assembly with driving plunger |
Related Child Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2011/021605Continuation-In-PartWO2011090956A2 (en) | 2007-10-02 | 2011-01-19 | Cartridge interface assembly |
| PCT/US2011/021605ContinuationWO2011090956A2 (en) | 2007-10-02 | 2011-01-19 | Cartridge interface assembly |
| US13/521,181Continuation-In-PartUS9259532B2 (en) | 2010-01-19 | 2011-01-19 | Cartridge interface assembly |
| US13/521,181ContinuationUS9259532B2 (en) | 2010-01-19 | 2011-01-19 | Cartridge interface assembly |
| US201213521181AContinuation | 2007-10-02 | 2012-07-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| US7967795B1 US7967795B1 (en) | 2011-06-28 |
| US20110178463A1true US20110178463A1 (en) | 2011-07-21 |
Family
ID=43903924
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US12/689,250ActiveUS7967795B1 (en) | 2007-10-02 | 2010-01-19 | Cartridge interface assembly with driving plunger |
| US13/521,181Active2031-10-16US9259532B2 (en) | 2010-01-19 | 2011-01-19 | Cartridge interface assembly |
| US14/880,673AbandonedUS20160030665A1 (en) | 2010-01-19 | 2015-10-12 | Cartridge interface assembly |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US13/521,181Active2031-10-16US9259532B2 (en) | 2010-01-19 | 2011-01-19 | Cartridge interface assembly |
| US14/880,673AbandonedUS20160030665A1 (en) | 2010-01-19 | 2015-10-12 | Cartridge interface assembly |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US7967795B1 (en) |
| EP (2) | EP2774637B1 (en) |
| JP (1) | JP5856077B2 (en) |
| CN (2) | CN104069563B (en) |
| BR (2) | BR112012017839B1 (en) |
| WO (1) | WO2011090956A2 (en) |
Cited By (24)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US8465455B2 (en) | 2009-09-15 | 2013-06-18 | Medimop Medical Projects Ltd. | Cartridge insertion assembly |
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Also Published As
| Publication number | Publication date |
|---|---|
| BR112012017839B1 (en) | 2020-04-07 |
| US9259532B2 (en) | 2016-02-16 |
| EP2525846A2 (en) | 2012-11-28 |
| EP2774637A1 (en) | 2014-09-10 |
| CN104069563B (en) | 2016-12-07 |
| JP5856077B2 (en) | 2016-02-09 |
| US20160030665A1 (en) | 2016-02-04 |
| CN102883761A (en) | 2013-01-16 |
| BR122019022494B1 (en) | 2020-10-27 |
| WO2011090956A3 (en) | 2011-11-24 |
| EP2525846B1 (en) | 2015-07-29 |
| CN102883761B (en) | 2016-01-20 |
| EP2774637B1 (en) | 2017-04-05 |
| US20130190691A1 (en) | 2013-07-25 |
| JP2013517095A (en) | 2013-05-16 |
| WO2011090956A2 (en) | 2011-07-28 |
| CN104069563A (en) | 2014-10-01 |
| US7967795B1 (en) | 2011-06-28 |
| BR112012017839A2 (en) | 2016-04-19 |
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