US20100256742A1 - Tapered Polymeric Stent And Method Of Fabricating Same - Google Patents

Abstract

A polymeric stent has an inner surface with an inner diameter that tapers continuously in size. A method for manufacturing a stent includes blow molding a polymeric tube within a mold having a tapered, cylindrical cavity such that the polymeric tube attains a corresponding tapered shape. The tapered tube is used as a substrate from which a laser cuts interconnecting stent struts.

Description

CROSS-REFERENCE TO RELATED APPLICATION
• This application is a divisional of application Ser. No. 11/479,111, filed Jun. 30, 2006, now U.S. Pat. No. 7,740,791, the entire contents of which is incorporated herein by reference.
FIELD OF THE INVENTION
• This invention relates to a method of fabricating a stent.
BACKGROUND OF THE INVENTION
• This invention relates to radially expandable endoprostheses which are adapted to be implanted in a body lumen. An “endoprosthesis” corresponds to an artificial implantable medical device that is placed inside the body. A “lumen” refers to a cavity of a tubular organ such as a blood vessel. These endoprostheses are commonly referred to as stents. Stents are generally cylindrically shaped devices which function to hold open and sometimes expand a segment of a blood vessel or other anatomical lumen such as urinary tracts and bile ducts. Stents are often used in the treatment of atherosclerotic stenosis in blood vessels. “Stenosis” refers to a narrowing or constriction of the diameter of a bodily passage or orifice. In such treatments, stents reinforce body vessels and prevent restenosis following angioplasty in the vascular system. “Restenosis” refers to the reoccurrence of stenosis in a blood vessel or heart valve after it has been treated (as by balloon angioplasty or valvuloplasty) with apparent success.
• The cylindrical structure of stents is typically composed of a scaffolding that includes a pattern or network of interconnecting structural elements or struts. The scaffolding can be formed from wires, tubes, or planar films of material rolled into a cylindrical shape. In addition, a medicated stent may be fabricated by coating the surface of either a metallic or polymeric scaffolding with a polymeric carrier. The polymeric carrier can include an active agent or drug. Furthermore, the pattern that makes up the stent allows the stent to be radially expandable and longitudinally flexible. Longitudinal flexibility facilitates delivery of the stent and radial rigidity is needed to hold open a body lumen. The pattern should be designed to maintain the necessary longitudinal flexibility and radial rigidity of the stent.
• A number of techniques have been suggested to fabricate stents from tubes and planar films or sheets. One such technique involves laser cutting or etching a pattern onto a material. Laser cutting may be performed on a planar film of a material which is then rolled into a tube. Alternatively, a desired pattern may be etched directly onto a tube. Fabricating a stent from a tube is preferable due to time and cost considerations. Other techniques involve cutting a desired pattern into a sheet or a tube via chemical etching or electrical discharge machining. Laser cutting of stents has been described in a number of publications including U.S. Pat. No. 5,780,807 to Saunders, U.S. Pat. No. 5,922,005 to Richter and U.S. Pat. No. 5,906,759 to Richter.
• It is desirable for a stent to have certain mechanical properties to facilitate delivery and deployment of a stent, especially in the bending portions of the stent that are bent during crimping and expansion of the stent. For example, longitudinal flexibility is important for successful delivery of the stent. In addition, radial rigidity and strength are vital characteristics in deployment and for holding open a body lumen. The pattern that makes up the stent allows the stent to be radially expandable and longitudinally flexible. The pattern should be designed to maintain the necessary longitudinal flexibility and radial rigidity of the stent. One technique for strengthening the bending portions of a stent is to laser cut the stent such as to widen the bending portions of the stent. However, upon crimping a stent that includes wider bending portions, oftentimes the stent flips upwards or “chip” when the strut is bent during crimping and/or expansion.
• What is needed in the art is a method of fabricating a stent to mechanically strengthen the stent in selected portions.
SUMMARY OF THE INVENTION
• Briefly and in general terms, the present invention is directed to a stent and a method of manufacturing a stent.
• In aspects of the invention, a method comprises disposing a polymeric tube into a cylindrical mold, the cylindrical mold having a variable diameter along a portion of the inside surface of the mold; radially expanding the tube by blowing a gas or liquid into the cylindrical mold, the outside surface of the tube conforming to the variable diameter portion of the inside surface of the mold, causing the radially expanded tube to have a variable diameter along the conformed length of the tube; and fabricating a stent from the expanded tube.
• In other aspects of the invention, a method comprises disposing a polymeric tube into a cylindrical mold, the cylindrical mold comprising an inner surface facing the polymeric tube, the inner surface having an inner diameter that varies along an axial length of the cylindrical mold. The method further comprises expanding the polymeric tube in radially outward directions to form an expanded tube, the expanding including blowing a gas or liquid into the cylindrical mold so that an outer surface of the polymeric tube conforms to the inner surface of the cylindrical mold and so that the outer surface of the expanded tube has an outer diameter that varies along an axial length of the expanded tube. The method further comprises fabricating a stent from the expanded tube.
• In other aspects of the invention, a stent is formed from a polymeric tube that was disposed into a cylindrical mold, subsequently expanded in radially outward directions in the cylindrical mold, and subsequently removed from the cylindrical mold and cut to form interconnecting stent struts, wherein the polymeric tube has an outer surface with an outer diameter that, after being removed from the cylindrical mold, varies along an axial length of the polymeric tube.
BRIEF DESCRIPTION OF THE DRAWINGS
• FIG. 1 depicts a tube for use in forming a stent.
• FIG. 2 depicts a three-dimensional stent with a pattern.
• FIG. 3A depicts an axial cross-section of a polymeric tube inserted in a cylindrical mold having indentations.
• FIG. 3B depicts an axial cross-section of a radially expanded tube after blow molding a gas or liquid into the mold.
• FIG. 3C depicts an axial cross-section of a radially expanded tube having protrusions.
• FIG. 3D depicts another embodiment of an axial cross-section of a radially expanded tube having protrusions.
• FIG. 4A depicts an axial cross-section of a polymeric tube inserted in a cylindrical mold having protrusions.
• FIG. 4B depicts an axial cross-section of a radially expanded tube after blow molding a gas into the mold.
• FIG. 4C depicts an axial cross-section of a radially expanded tube having indentions.
• FIG. 5A depicts an axial cross-section of a polymeric tube inserted in a tapered cylindrical mold.
• FIG. 5B depicts an axial cross-section of a radially expanded tube after blowing a gas or liquid into the mold.
• FIG. 5C depicts an axial cross-section of a tapered radially expanded tube.
• FIG. 6A depicts a portion of a strut having a uniform thickness and a relatively wider bending portion.
• FIG. 6B depicts a portion of a strut after crimping, where portion of strut has a uniform thickness and the wider bending portion that has flipped upward.
• FIG. 7A depicts a portion of a strut before crimping having a relatively thicker bending portion.
• FIG. 7B depicts a portion of a strut after crimping having a relatively thicker bending portion.
• FIG. 7C depicts a portion of a strut having a relatively thicker bending portion, and, in addition, features on the abluminal or luminal side.
• FIG. 8 depicts one embodiment of a machine-controlled system for laser machining a tube, circumventing any features that have been formed on the stent.
• FIG. 9(a) depicts a close-up axial view of a region where a laser beam interacts with a tube having features.
• FIG. 9(b) depicts a close-up end view of a region where a laser beam interacts with a tube having features.
DETAILED DESCRIPTION OF THE INVENTION
• For the purposes of the present invention, the following terms and definitions apply:
• “Stress” refers to force per unit area, as in the force acting through a small area within a plane. Stress can be divided into components, normal and parallel to the plane, called normal stress and shear stress, respectively. True stress denotes the stress where force and area are measured at the same time. Conventional stress, as applied to tension and compression tests, is force divided by the original gauge length.
• “Elastic limit” refers to the maximum stress that a material will withstand without permanent deformation.
• “Strength” refers to the maximum stress in a direction in testing which a material will withstand prior to fracture. The ultimate strength is calculated from the maximum load applied during the test divided by the original cross-sectional area.
• “Strain” refers to the amount of elongation or compression that occurs in a material at a given stress or load. Elongation may be defined as the increase in length which occurs when subjected to stress. It is typically expressed as a percentage of the original length.
• The “glass transition temperature,” Tg, is the temperature at which the amorphous domains of a polymer change from a brittle vitreous state to a plastic state at atmospheric pressure. In other words, the Tg corresponds to the temperature where the onset of segmental motion in the chains of the polymer occurs. Tg of a given polymer can be dependent on the heating rate and can be influenced by the thermal history of the polymer. Above Tg, molecular orientation may be induced with applied stress since rotation of polymer chains, and hence segmental mobility is possible. Between Tg and the melting temperature of the polymer, T_m, rotational barriers exist, however, the barriers are not great enough to substantially prevent segmental mobility. As the temperature of a polymer is increased above Tg, the energy barriers to rotation decrease and segmental mobility of polymer chains tend to increase. As a result, as the temperature increases, molecular orientation is more easily induced with applied stress.
• Embodiments of the method can be used to fabricate devices including, but not limited to, stents, balloon-expandable stents, stent-grafts, and grafts. Various embodiments to manufacture a stent with desirable features are described herein. Some embodiments to manufacture the device include fabricating the stent from a polymer conduit or tube. The tube may be cylindrical or substantially cylindrical in shape. For example,FIG. 1 depicts atube100.Tube100 is a cylinder with anoutside diameter110 and aninside diameter120.FIG. 1 also depicts anoutside surface130 and acylindrical axis140 oftube100. When referred to below, unless otherwise specified, the “diameter” of the tube refers to the outside diameter of tube.
• The polymeric tube may be used to fabricate a stent. Fabrication may include forming a pattern that includes at least one interconnecting element or strut on the elongated tube. The stent may be formed by laser cutting a pattern on the elongated tube. Representative examples of lasers that may be used include an ultra fast laser, excimer, carbon dioxide, and YAG. Chemical etching may also be used to form a pattern on the elongated tube.FIG. 2 depicts a three-dimensional view of astent150 which may be formed fromtube100 inFIG. 1.FIG. 2 depicts a pattern or network ofstruts160. The pattern is not limited to the depicted stent pattern.
• The polymeric tube for use in manufacturing a stent has a desired strength and flexibility in the longitudinal direction, as shown by anarrow135 inFIG. 1, and in the transverse or radial direction, as shown by anarrow145 inFIG. 1. The desired strength and flexibility can be induced by radial expansion and/or axial deformation. A tube can be radially deformed by blow molding. The invention provides blow molding a tube to form a tube having a variable diameter and/or features such as indentations. There are many advantages to fabricating tubes with a variable diameter and/or features such as indentions, such as increased stent retention and features such as pockets filled with drugs or radio-opaque substances.
• Several embodiments disclosed herein provide applying radial pressure to a polymeric tube by positioning the polymeric tube within a cylindrical mold. The cylindrical mold may include features where, upon conveying a gas or liquid at a selected pressure into a proximal end of the polymeric tube, the cylindrical mold acts to control the diameter of the expanded polymeric tube by limiting the expansion to the inside diameter of the cylindrical mold. The pressure of the conveyed gas may be used to control the expansion of the polymeric tube to a desired diameter, while a distal end of the polymeric tube may be closed. The inside diameter of the cylindrical mold with features corresponds to the desired shape and diameter of the formed polymeric tube. The inside surface of the mold may include features such as protrusions, projections, grooves, indentations, flanges, overhangs, and extensions. Other features are also possible. The embodiments disclosed herein allow formation of a tube with a variable diameter and/or features on the outside surface of the tube. The invention also provides fabricating a stent having portions that are thicker than other portions of the stent.
• FIG. 3A depicts an axial cross-section of apolymeric tube300 with an outside diameter310 positioned within acylindrical mold320 havingindentations330 on the inside surface of themold320.Cylindrical mold320 withindentations330 acts to limit the expansion ofpolymeric tube300 to the inside surface ofmold320. The indentations form atube300 with a variable diameter. When thepolymeric tube300 expands from diameter310 todiameter340,protrusions390 are formed on the outside surface of thepolymeric tube300.
• Polymeric tube300 may be closed at adistal end350 to conform to the outside surface ofmold320. Any gas, such as air, may be conveyed, as indicated by anarrow360, into an openproximal end370 ofpolymeric tube300. A liquid may also be conveyed into the openproximal end370 to provide pressure on the inside of the tube. The gas or liquid can be heated to a temperature sufficient to deform the polymeric tube. This temperature can be above the glass transition temperature of the polymer. The pressure of the gas is selected to sufficiently expand the polymeric tube to conform to the inside surface ofcylindrical mold320.Polymeric tube300 may be heated by the gas or liquid to a temperature above ambient temperature, for example above Tg of the polymer. Alternatively, heat may be applied to the exterior ofcylindrical mold320. The conveyed gas combined with the applied heat may act to radially expandpolymeric tube300, as indicated by anarrow380.
• FIG. 3B depicts an axial cross-section of apolymeric tube300 havingprotrusions390 that are formed after blowing a gas at a selected temperature and pressure into thecylindrical mold320. As depicted inFIG. 3C,tube300 includesprotrusions390 that are formed during the blow molding process.
• FIG. 4A depicts an axial cross-section of apolymeric tube400 having an outside diameter310 positioned within acylindrical mold410 havingprotrusions420.Cylindrical mold410 withprotrusions420 acts to limit the expansion ofpolymeric tube400 to an expandeddiameter340, which conforms to the surface of the mold. When apolymeric tube400 expands from diameter310,indentations430 are formed inpolymeric tube400.Cylindrical mold410 includesprotrusions420.FIG. 4B depicts an axial cross-section of a radially expandedtube400 after blowing a gas or liquid at a selected temperature and pressure into thecylindrical mold410. As depicted inFIG. 4B,indentations430 are formed inpolymeric tube400 by blow moldingpolymeric tube400 againstcylindrical mold410 havingprotrusions420. As depicted inFIG. 4C,tube400 includesgrooves430 formed during the blow molding process. The indentations in the tube are arranged in the tube as desired. For example, if the indentations are to be used as depots to hold drugs, the indentations may be arranged linearly along the entire length of the tube. Also, the indentations may be arranged such that when the pattern is cut into the tube, the indentations encompass portions of the stent requiring flexibility. The indentations can be of any shape, not just circular. The indentations of the tube are formed to coincide with the specific parts of the stent pattern. For example,FIG. 4D depictsstent strut440 havingindentations450 and aprotrusion460 on the bendingportion465 of the stent portion. One advantage to forming features on a stent by blow molding rather than by laser cutting is that blow molding avoids deleterious effects on the mechanical portions of the stent caused by heat from lasers that create a heat affected zone.
• FIG. 5A depicts an axial cross-section of apolymeric tube500 with anoutside diameter520 positioned within acylindrical mold510, wherecylindrical mold510 is tapered along its length.Cylindrical mold510 acts to limit the expansion ofpolymeric tube500 to an expandeddiameter530 on one end of thepolymeric tube500 anddiameter540 on the other end of thepolymeric tube500.Cylindrical mold510 has a tapered diameter, such that thediameter540 on the end of formedtube500 is expanded more than theother end530 of tube upon blow molding.FIG. 5B depicts an axial cross-section of a radially expandedtube500 after blowing a gas at a selected temperature and pressure into thecylindrical mold510. A taperedpolymeric tube500 is formed by expandingpolymeric tube500 to conform to the inner surface ofcylindrical mold510. As depicted inFIG. 5C, formedtube500 includes a tapered diameter fromdiameter540 todiameter530. There are many advantages to using a tapered stent. For example, the tapered stent may be adapted to improve the attachment of the stent to the delivery system and facilitate the delivery of the mounted stent into and through a bodily lumen. AlthoughFIG. 5 depict a uniform tapering shape, the invention includes arbitrary axial cross-sections which can be formed by blow molding.
• As mentioned previously, selected portions of the stent using blow molding may be formed to have greater or lesser mass relative to other portions of the stent. For example, high strain regions may be made up of more polymeric mass relative to other portions of the stent. Similarly, lower strain regions that require flexibility may be of a lesser mass.
• FIG. 6A depicts a portion of astrut600 having a uniform thickness on thesidewall635 and a relativelywider bending portion620, where width is indicated by “W”. That is,thickness610 of bendingportion620 is substantially the same as the thickness ofends615 ofstrut600.Strut600 includes a luminal or abluminal side and aside wall625. The bendingportion620 ofstrut600 is bent during crimping the stent onto a balloon-catheter assembly and during expansion of the stent when the stent is deployed. If the abluminal orluminal surface625 of bendingportion620 is made wider, bendingportion620 ofstrut600 is caused to flip upwards or “chip” when the strut is bent600 during crimping and/or expansion as depicted byarrows630. Chipping can become problematic because stent protrusion and non-uniform apposition on the vessel wall is unwanted in a vessel wall.
• FIGS. 7A and 7B depicts a portion of astrut700 having a variable thickness. That is,thickness710 of the bendingportion720 is greater than the thickness of theends715 ofstrut700.Strut700 includes a bendingportion720 that is bent during crimping the stent onto a balloon-catheter assembly and/or during expanding the stent when the stent is deployed. As depicted inFIG. 7B, the bendingportion720 ofstrut700 may have a low or no tendency to flip outward when the strut is bent during crimping, for example. The greater thickness of thesidewall735 in bendingportion720 of thestent strut700 provides a greater strength with little or no out of plane bending as shown inFIG. 6B. In addition, strut portions requiring greater flexibility, such as linking struts, may be formed to be thinner than other strut portions. Therefore, with blow molding, parts having various thicknesses can be designed to be at selected portions of a stent.
• In one embodiment, as depicted inFIG. 7C, a portion of astrut700 has athicker bending portion720 as well asprotrusions730 located at selected portions of abluminal orluminal surface725. In one embodiment, a portion of strut is made to be thicker as well as wider relative to other portions of the stent.
• In one embodiment, the polymeric tube may be heated such that the temperature of the polymeric tube is greater than or equal to Tg and less than T_mof the polymer. Heating above Tg facilitates expansion, since a polymer becomes more flexible above Tg.
• After the polymeric tube is radially expanded by blow molding the tube, it may be desirable to cool the radially expanded tube below the Tg of the polymer to retain induced molecular orientation. Some embodiments may include cooling the deformed tube prior to fabrication of the medical device. The deformed tube may be cooled at a temperature below an ambient temperature to below the Tg of the polymer. Alternatively, cooling the deformed polymer tube may include cooling the deformed polymer tube at a temperature at or near an ambient temperature to below the Tg of the polymer.
• After the polymeric tube is radially expanded by blow molding the tube, the tube may be laser cut to form a stent. A stent may be fabricated by use of a laser beam collimated to a 1 to 10 mm beam diameter. The tube is then cut by focusing a beam, such as a 0.5 to 2 mm wide beam, on the polymeric tube. A stent pattern may then be cut into the tube by moving the tube in an axial and rotary direction with respect to the cutting beam or by moving the beam.
• FIG. 8 depicts an embodiment of a portion of a machine-controlled system for laser machining a tube. InFIG. 8, apolymeric tube800 is disposed in a rotatable collet fixture810 of a machine-controlledapparatus820 forpositioning tube800 relative to alaser830. According to machine-encoded instructions,tube800 is rotated and moved axially relative tolaser830 which may also be machine-controlled. The laser selectively removes the material from the tube resulting in a pattern cut into thetube800. Thetube800 is therefore cut into the discrete pattern of a finished stent.
• The process of cutting a pattern for the stent into the tube is automated except for loading and unloading the length oftube800. Referring again toFIG. 8, the process may be done, for example, using a CNC-opposingcollet fixture840 for axial rotation of the length of tubing.Collet fixture840 may act in conjunction with a CNC X/Y table850 to move the length of tube axially relative to a machine-controlledlaser830 as described. The entire space between collets can be patterned using a laser set-up of the foregoing example. The program for control of the apparatus is dependent on the particular configuration used and the pattern formed. Therefore, a pattern that circumvents any features formed on the tube can be accomplished using the program for control of the apparatus.
• Machining a fine structure also requires the ability to manipulate the tube with precision. CNC equipment manufactured and sold by Anorad Corporation in Hauppauge, N.Y. may be used for positioning the tube. In addition, a unique rotary mechanism may be used that allows the computer program to be written as if the pattern were being machined from a flat sheet, allowing utilization of both circular and linear interpolation in programming. Thus, the axial and rotary motion may be controlled by a CNC system. A CNC controlled axis may also control the focus position on the polymeric tube. After indexing the CNC system to a specific position on tube, the system traces the pattern in the x, y, z coordinate system. Since the finished structure of the stent is very small, a precision drive mechanism is required that supports and drives both ends of the tubular structure as it is cut. Since both ends are driven, they are preferably aligned and precisely synchronized. Otherwise, as the stent is being cut, the stent may twist and distort.
• The stent produces stents with a fine precision structure cut from a small diameter thin-walled cylindrical tube. Cutting a fine structure around features on a stent surface created by the present invention (e.g., a 0.0035 inch strut width (0.889 mm)) requires precise laser focusing and minimal heat input. To satisfy these requirements, a laser technology adapted to micro-machine the tube may be implemented according to the present embodiments.
• Additionally,FIGS. 9(a) and9(b) show thatapparatus900 incorporates a monocular viewing, focusing, and cuttinghead930. Arotary axis940 andX-Y stages950 for rotating and translating the work piece are also shown. ACNC controller960 is also incorporated intoapparatus300.
• FIG. 9(a) depicts a close-up axial view of the region where the laser beam interacts with the substrate target material. Alaser beam900 is focused by a focusinglens910 on atube920 is supported by a CNC controlledrotary collet930 at one end and atube support pin940 at another end.
• As shown byFIG. 9(a), the laser can incorporate a coaxialgas jet assembly950 having acoaxial gas jet960 and anozzle970 that helps to remove debris from the kerf and cools the region where the beam interacts with the material as the beam cuts and vaporizes a substrate. Coaxial gas jet nozzle970 (e.g., 0.018 inch diameter (0.457 mm)) is centered around afocused beam980 with approximately 0.010 inch (2.54 mm) between atip990 ofnozzle970 and atube920. In certain embodiments, an optical system for modifying a laser beam according to the embodiments described herein may be positioned between cutting head930 (depicted inFIGS. 9(a) and9(b)) and the substrate target material.
• It may also be necessary to blocklaser beam980 as it cuts through the top surface of the tube to prevent the beam, along with the molten material and debris from the cut, from impinging on the inside opposite surface oftube990. To this end, a mandrel992 (e.g., approx. 0.034 inch diameter (0.864 mm)) supported by amandrel beam block995 is placed inside the tube and is allowed to roll on the bottom of thetube985 as the pattern is cut, which acts as a beam/debris block protecting the far wall inner diameter. A close-up end view alongmandrel beam block995 showslaser beam980 impinging ontube985 inFIG. 9(b).
• Hence, the laser enables the machining of narrow kerf widths to circumvent the features formed on the stent surface, while minimizing the heat input into the material. In this way, smooth, narrow cuts in a tube with very fine geometries are made without damaging the narrow struts that define the stent structure.
• The stent can be made partially or completely from a biodegradable, bioabsorbable, or biostable polymer. Biostable refers to polymers that are not biodegradable. The terms biodegradable, bioabsorbable, and bioerodable are used interchangeably and refer to polymers that are capable of being completely degraded and/or eroded when exposed to bodily fluids such as blood and can be gradually resorbed, absorbed and/or eliminated by the body. The processes of breaking down and eventual absorption and elimination of the polymer can be caused by, for example, hydrolysis, metabolic processes, bulk or surface erosion, and the like. For stents made from a biodegradable polymer, the stent is intended to remain in the body for a duration of time until its intended function is accomplished.
• Representative examples of polymers that may be used to fabricate a stent using the methods disclosed herein include poly(N-acetylglucosamine) (Chitin), Chitoson, poly(hydroxyvalerate), poly(lactide-co-glycolide), poly(hydroxybutyrate), poly(hydroxybutyrate-co-valerate), polyorthoester, polyanhydride, poly(glycolic acid), poly(D,L-lactic acid), poly(glycolic acid-co-trimethylene carbonate), poly(trimethylene carbonate), co-poly(ether-esters) (e.g. PEO/PLA), polyphosphazenes, biomolecules (such as fibrin, fibrinogen, cellulose, starch, collagen and hyaluronic acid), polyurethanes, silicones, polyesters, polyolefins, polyisobutylene and ethylene-alphaolefin copolymers, acrylic polymers and copolymers other than polyacrylates, vinyl halide polymers and copolymers (such as polyvinyl chloride), polyvinyl ethers (such as polyvinyl methyl ether), polyvinylidene halides (such as polyvinylidene chloride), polyacrylonitrile, polyvinyl ketones, polyvinyl aromatics (such as polystyrene), polyvinyl esters (such as polyvinyl acetate), acrylonitrile-styrene copolymers, ABS resins, polyamides (such as Nylon 66 and polycaprolactam), polycarbonates, polyoxymethylenes, polyimides, polyethers, polyurethanes, rayon, rayon-triacetate, cellulose, cellulose acetate, cellulose butyrate, cellulose acetate butyrate, cellophane, cellulose nitrate, cellulose propionate, cellulose ethers, and carboxymethyl cellulose. Additional representative examples of polymers that may be especially well suited for use in fabricating a stent according to the methods disclosed herein include ethylene vinyl alcohol copolymer (commonly known by the generic name EVOH or by the trade name EVAL), poly(butyl methacrylate), poly(vinylidene fluoride-co-hexafluororpropene) (e.g., SOLEF 21508, available from Solvay Solexis PVDF, Thorofare, N.J.), polyvinylidene fluoride (otherwise known as KYNAR, available from ATOFINA Chemicals, Philadelphia, Pa.), poly(L-lactic acid), poly(caprolactone), ethylene-vinyl acetate copolymers, and polyethylene glycol.
• While particular embodiments of the present invention have been shown and described, it will be obvious to those skilled in the art that changes and modifications can be made without departing from this invention in its broader aspects. Therefore, the appended claims are to encompass within their scope all such changes and modifications as fall within the true spirit and scope of this invention.

Claims (20)

1. Method of manufacturing a stent, the method comprising:

disposing a polymeric tube into a cylindrical mold, the cylindrical mold comprising an inner surface facing the polymeric tube, the inner surface having an inner diameter that varies along an axial length of the cylindrical mold;

expanding the polymeric tube in radially outward directions to form an expanded tube, the expanding including blowing a gas or liquid into the cylindrical mold so that an outer surface of the polymeric tube conforms to the inner surface of the cylindrical mold and so that the outer surface of the expanded tube has an outer diameter that varies along an axial length of the expanded tube; and

fabricating a stent from the expanded tube.

2. The method ofclaim 1, wherein the outer surface of the expanded tube is tapered such that the outer diameter increases from an end segment of the expanded tube to an opposite end segment of the expanded tube.

3. The method ofclaim 2, wherein the outer diameter increases continuously from the end segment to the opposite end segment.

4. The method ofclaim 1, wherein the outer surface forms a conical shape.

5. The method ofclaim 1, wherein the expanded tube comprises a first end segment, a second end segment opposite the first end segment, and a central segment between the first and second end segments, and wherein the outer surface of the expanded tube is tapered such that the outer diameter is greater at the first end segment than at the central segment and is greater at the central segment than at the second end segment.

6. The method ofclaim 1, wherein the expanded tube comprises a first end segment, a second end segment opposite the first end segment, and a central segment between the first and second end segments, and wherein the outer diameter is larger at the central segment than at the first and second end segments.

7. The method ofclaim 1, wherein the expanded tube comprises a first end segment, a second end segment opposite the first end segment, and a central segment between the first and second end segments, and wherein the outer surface of the expanded tube is tapered such that the outer diameter increases from the first end segment to the central segment.

8. The method ofclaim 7, wherein the outer diameter increases from the second end segment to the central segment.

9. The method ofclaim 1, further comprising heating the polymeric tube to a temperature above Tg of the polymer either before or during the expanding.

10. The method ofclaim 1, further comprising heating the polymeric tube to a temperature above Tg of the polymer before and during the expanding.

11. The method ofclaim 10, wherein the polymeric tube is heated by the liquid or gas blown into the cylindrical mold.

12. The method ofclaim 1, wherein the fabricating includes cutting a pattern of interconnecting struts from the expanded tube.

13. The method ofclaim 12, wherein the pattern of interconnecting struts is configured to be crimped and expanded.

14. The method ofclaim 1, wherein the polymeric tube is a biodegradable and/or biostable polymer.

15. The method ofclaim 1, wherein the polymeric tube is made of poly(L-lactic acid).

16. The method ofclaim 1, wherein the polymeric tube is made of poly(lactide-co-glycolide).

17. A stent formed from a polymeric tube that was disposed into a cylindrical mold, subsequently expanded in radially outward directions in the cylindrical mold, and subsequently removed from the cylindrical mold and cut to form interconnecting stent struts, wherein the polymeric tube has an outer surface with an outer diameter that, after being removed from the cylindrical mold, varies along an axial length of the polymeric tube.

18. The stent ofclaim 17, wherein the cylindrical mold comprises an inner surface having an inner diameter that varies along an axial length of the cylindrical mold, and the outer surface of the polymeric tube has a shape corresponding to the inner surface of the cylindrical mold.

19. The method ofclaim 1, wherein the polymeric tube comprises a first end segment, a second end segment opposite the first end segment, and a central segment between the first and second end segments, and wherein after the polymeric tube is removed from the cylindrical mold, the outer surface of the polymeric tube is tapered such that the outer diameter is greater at the first end segment than at the central segment and is greater at the central segment than at the second end segment.

20. The method ofclaim 1, wherein the polymeric tube comprises a first end segment, a second end segment opposite the first end segment, and a central segment between the first and second end segments, and wherein after the polymeric tube is removed from the cylindrical mold, the outer diameter is larger at the central segment than at the first and second end segments.

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