US20090177032A1

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Info

Publication number: US20090177032A1
Application number: US12/350,637
Authority: US
Inventors: Jeffrey M. Garibaldi; Walter M. Blume; Gerard H. Epplin
Original assignee: Individual
Current assignee: Individual
Priority date: 1999-04-14
Filing date: 2009-01-08
Publication date: 2009-07-09
Also published as: AU4237600A; US6902528B1; WO2000060996A1; US20050033162A1

Abstract

A magnetically navigable endoscope system includes an endoscope having a proximal end and a distal end, the distal end having a magnetic body; a component which transmits an image, associated with the distal end; a display component for displaying the image; a magnetic field generating apparatus for generating a magnetic field to orient the magnetic body and thus the distal end of the endoscope; and a controller coordinated with the display for controlling the magnetic field generating apparatus to selectively change the magnetic field to change the orientation of the magnetic body and thus the distal end of the endoscope.

Description

FIELD OF THE INVENTION

This invention relates to magnetically controlling endoscopes, and in particular to a method and apparatus for magnetically controlling endoscopes in body lumens and cavities.

BACKGROUND OF THE INVENTION

Endoscopes, which allow viewing of the interior of body lumens and cavities, are increasingly used in conducting medical procedures. One of the greatest difficulties in using endoscopes is navigating the distal end of the endoscope within the body to the procedure site. Standard endoscopes are steered using articulation wires secured to the distal end and which extend to the proximal end, where they can be operated by mechanisms incorporated in the proximal end of the endoscope. The articulation wires pull the distal end of the endoscope, causing it to articulate in the desired direction. Some endoscopes have a single plane of articulation, and navigation is affected by a combination of articulation and rotation of the endoscope. Other endoscopes have two planes of articulation, and navigation is effected by combinations of movement in the two planes. Neither of these types of endoscopes provides simple and easy omnidirectional navigation. Another problem with wire-controlled endoscopes is that the control over the movement of the tip of the endoscope diminishes with each successive bend in the endoscope, so as the endoscope is navigated through a particularly tortuous path through the body, navigation becomes increasingly difficult.

Magnetic navigation of an endoscope eliminates the difficulties encountered with mechanical navigation. A magnetic field can be generated to orient the tip of the endoscope in virtually any direction, and is not limited to movement in one or two planes. Furthermore, tip deflection is based solely on the strength of the magnetic field, and thus navigation is not affected by the path of the endoscope. However, it can be difficult for a medical professional to quickly and easily control the magnetic field in order to effectively magnetically navigate an endoscope. What has been needed is an effective way of controlling the application of magnetic fields to both orient and move magnetic devices, such as endoscopes.

SUMMARY OF THE INVENTION

The present invention provides a method and apparatus for magnetically navigating devices such as an endoscope through body lumens and cavities. Generally the magnetically navigable endoscope system of the present invention comprises an endoscope with a magnetic member, a component in the endoscope which transmits an image associated with the endoscope's distal end, a display to view the image, an input device, a computer with image processing software and a magnetic field generating apparatus for generating a magnetic field to orient the magnetic member. The endoscope construction can be similar to a standard endoscope without the articulation wires. The magnetic member is contained in the distal segment of the endoscope to orient the endoscope upon the application of an external magnetic field. The video image (e.g., a optical, ultrasound, or infrared image) from the endoscope is sent to a computer with image processing software, which provides general graphics overlays (i.e. lines and text) and image rotation functions. An input device such as a controller connected to the computer allows a physician to specify the change in deflection angle of the endoscope's distal end. As the controller is moved to the left, right, forward or backward positions, the computer senses the controller's position and accordingly processes a change in the magnetic field direction. The computer then causes the magnetic field generating apparatus to apply the new magnetic field direction.

Generally the method of magnetically navigating endoscopes of the present invention comprises specifying the direction to orient the endoscope using a variety of input devices and user interfaces, while the endoscope is manually or automatically advanced in the body lumen or cavity.

The method of the present invention can also be used in navigating the distal end of an endoscope in the bronchia; navigating the distal end of an endoscope in the brain; navigating the distal end of an endoscope in the colon and/or intestines; and navigating the distal end of the endoscope in the heart.

The endoscopes used with the method of this invention are preferably constructed to facilitate the recovery and re-integration of the image bundle, the light bundle, and the magnetics into new endoscopes, so that the endoscopes can be made disposable. Thus the entire endoscope of the present invention can be made re-usable or disposable.

The magnetically navigable endoscope system of the present invention allows a health care professional to quickly and intuitively navigate the endoscopes through body lumens and cavities. In the preferred embodiment, the system interface allows the health care professional to move the endoscope through the body without having to get involved in directly controlling the magnetic field direction and strength. This is achieved by allowing the physician to directly visualize the body lumen or cavity in which the endoscope is located, and navigate based on this viewed image.

According to the method and apparatus of this invention, the distal end of an endoscope can be oriented in virtually any direction. Moreover, the navigation is unaffected by the path of the endoscope. These and other features and advantages will be in part apparent, and in part pointed out hereinafter.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a schematic view of an apparatus for magnetically controlling endoscopes according to the principles of this invention;

FIG. 2 is a schematic side elevation view of an endoscope for use with this invention;

FIG. 3 is a transverse cross-sectional view of the endoscope;

FIG. 4 is a side elevation view of the distal end portion of the endoscope;

FIG. 5 is a perspective view of a first alternate construction of the distal end portion of the endoscope;

FIG. 6 is a side elevation view of a second alternate construction of the distal end of the endoscope;

FIG. 7 is a longitudinal cross-sectional view of a third alternate construction of the distal end of the endoscope;

FIG. 8 is a side elevation view of an alternate endoscope construction, including an integral controller;

FIG. 9 is a front elevation view of a possible display for use in navigating endoscopes according to the present invention; and

FIG. 10 is an end elevation view of the distal end of an endoscope provided with a plurality of pressure sensors around the circumference of its distal end;

FIG. 11 is a perspective view of the distal end of the endoscope showing an exemplary construction of the pressure sensors

FIG. 12 is a view of the distal end of an endoscope being navigating within a kidney.

Corresponding reference numerals indicate corresponding parts throughout the several views of the drawings.

DETAILED DESCRIPTION OF THE INVENTION

A system for navigating endoscopes through body lumens and cavities is indicated generally as20 inFIG. 1. Thesystem20 comprises anendoscope22, alight source24 connected to the endoscope to provide light to illuminate the body lumen or cavity surrounding the distal end of the endoscope, animaging device26, for example a camera, for capturing images of the body lumen or cavity surrounding the distal end of the endoscope and acomputer28 for processing the image captured by theimaging device26 and displaying the image on adisplay30. Of course instead of a camera for capturing optical images, the imaging device could be an ultrasonic imaging device or an infrared imaging device, or some other suitable imaging device. Thecomputer28 is also connected to a controller, such as acontroller32, for receiving input for controllingendoscope22, and processing the input to create an output control signal to the magneticfield generating device34 to control the magnetic field applied to the distal end of the endoscope to move (orient and/or advance) the distal end of the endoscope in the desired direction.

The magneticfield generating device34 is one that is capable of generating a magnetic field of selected direction and strength in an operating volume within a patient. An example of such a system is that disclosed in co-assigned, copending U.S. utility patent application Ser. No. 09/211,723, field Dec. 14, 1998, entitled Open Field System for Magnetic Surgery, incorporated herein by reference. The magnetic field direction and field strength in this system can be controlled by controlling the currents applied to the electromagnetic coils comprising the system. One of ordinary skill in the art could easily implement a software algorithm to control a system which provides appropriate magnetic field direction and strength to achieve a selected orientation or movement. The magnetic field for navigating the endoscope in accordance with the present invention could also be provided with an articulated magnet, for example like that disclosed in co-assigned, co-pending U.S. Patent Application Ser. No. 60/118,959, filed Feb. 4, 1999, entitled An Efficient Permanent Magnet Means to Produce an Arbitrary Field and incorporated herein by reference.

Theendoscope22 is best shown inFIG. 2. Theendoscope22 has aproximal end36 and adistal end38. As shown inFIG. 3, the endoscope has a plurality of inner lumens, depending upon the application. In this preferred embodiment there are four

such lumens

42,44,46 and48.

Thelumen42 forms a workingchannel52 extending the entire length of theendoscope22, and providing a passage for one or more surgical instruments.

Thelumen44 forms a passage forlight bundle54 which is preferably a bundle of optical fibers extending substantially the length of theendoscope22. The proximal end of thelight bundle54 is optically connected to aconnector56 on the side of the proximal end portion of theendoscope22, and the distal end of thelight bundle54 terminates at thedistal end38 of the endoscope. Thelight source24 is connected viaconnector56 to thelight bundle54 to illuminate the area surrounding thedistal end38 of theendoscope22. Of course, with an imaging system other than an optical system, e.g., ultrasonic or infrared imaging, thelight source24 is not necessary.

Thelumen46 forms a passage forimage path56 which, in the case of anoptical imaging device26, is preferably a bundle of optical fibers extending substantially the length of theendoscope22. In the case of an ultrasonic orinfrared imaging device26, theimaging path56 could be a wire or cable. The proximal end of theimage path56 is connected to aconnector60 on the distal end of theendoscope22, and the distal end of theimage bundle56 terminates at thedistal end38 of the endoscope. Theimaging device26 is connected viaconnector60 to theimage path56 to receive images from the area surrounding thedistal end38 of theendoscope22. Theimaging device26 is in turn connected to thecomputer28, which processes the image signal from the imaging device and displays in the image on thedisplay30.

Thelumen48 forms anoptional magnet channel60 which allows one ormore magnets62 to be positioned along the length of theendoscope22 to permit the endoscope to be moved (oriented and/or advanced) by an applied magnetic field. The magnets could be made either of a permanent magnetic material, such as neodymium-iron-boron, or of a permeable magnetic material, such as cold rolled steel or Hiperco™. Themagnets62 are shaped to maximize their field strength for their size, and thus are typically cylindrical, and are preferably placed adjacent thedistal end38 of theendoscope22. The distal end portion of the endoscope, showing the position of themagnet62, is shown inFIG. 4.

Theendoscope22, and in particular the

lumens

42,44,46, and48, and the space surrounding the

lumens

42,44,46, and48, can be filled with a filler to secure the components in the endoscope. However portions of the filler along the length of the endoscope can be selectively removed by leaching to reduce the weight and stiffness of the catheter. For some applications, substantially all of the filler between the proximal and distal ends will be leached away, leaving the filler at the proximal and distal ends to hold the components in their proper orientation. It is also possible that selected portions of the filler material between the proximal and distal ends of the endoscope are leached.

The flexibility of the endoscope can vary along its length, to suit the particular function of the endoscope. In most embodiments, it is preferred that at least the distal end portion be highly flexible so that it can readily align with an applied magnetic field. For most applications, a highly flexible portion at least 3 cm long should be sufficient. The flexibility is preferably such that the distal end of the endoscope can bend at least about 120° with respect to the longitudinal axis of the immediately proximal portion of the endoscope, with a radius of curvature of about 2 cm or less.

A first alternate construction of the distal end of the endoscope is shown inFIG. 5. As shown inFIG. 5 the portion of the endoscope adjacent thedistal end38 can include ahelical coil64. Thecoil64 can be made of a highly flexible permeable magnetic material to provide an alignment force of the end portion of the endoscope under an applied magnetic field. Thecoil64 could also be made of a non-magnetic material to simply provide axial stiffness when the tip is arched by the magnetic field.

A second alternate construction of thedistal end38 of theendoscope22 is shown inFIG. 6, in which the distal end of the endoscope is provided with a machinedtip66, preferably made from a permanent or permeable magnetic material. The machinedtip66 can provide the sole or additional alignment force for the tip to orient with the externally applied magnetic field.

A third alternate construction of thedistal end38 of theendoscope22 is shown inFIG. 7, in which multiple magnet bodies are used to achieve greater magnetic torque. As shown inFIG. 7, the distal end section of the third alternate construction of the endoscope contains a plurality of magnet rings67. Therings67 are retained in the distal end section, and do not significantly impair the flexibility of the distal end section. Therings67 provide sufficient magnet material so that a substantial torque can be applied to the distal end of the endoscope.

An alternate endoscope for use with this invention is indicated generally as22′ inFIG. 8.Endoscope22′ is similar in construction toendoscope22, and corresponding parts are identified with corresponding reference numerals. Unlikeendoscope22,endoscope22′ includes anintegral controller68 which can be used instead of thecontroller32. This allows the physician to navigate theendoscope22′ without removing his or her hands from the endoscope. Thecontroller68 could consist of a joystick attached to the endoscope's proximal end which the physician can manipulate to control the distal end of the endoscope. Thecontroller68 could alternatively consist of one or one or more sensors for sensing the orientation of the proximal end of the endoscope, and in which this sensed orientation can indicate the desired direction for the distal end of the endoscope. Thus by simply manipulating the proximal end of the endoscope, the physician can control the distal end of the endoscope.

Thecomputer28 processes the image from theimaging device26, adds an overlay, such as that shown inFIG. 9, and displays the image in an orientation intuitively coordinated with thecontroller32. In this preferred embodiment, the controller and computer operate to control the externally applied magnetic field so that moving the controller left causes the magneticfield generating device24 to change the applied magnetic field and move thedistal end38 of theendoscope22 left as viewed on thedisplay30. Moving thecontroller32 right causes the magneticfield generating device24 to change the applied magnetic field and move thedistal end38 of theendoscope22 right as viewed on thedisplay30. Moving thecontroller32 forward causes the magneticfield generating device24 to change the applied magnetic field and move thedistal end38 of the endoscope down as viewed on thedisplay30. Moving thecontroller32 backward causes the magneticfield generating device24 to change the applied magnetic field and move thedistal end38 of theendoscope22 up as viewed on thedisplay30. However, these corresponding directions could be swapped, depending upon the user's preference.

To facilitate navigation it is desirable to have the display image coordinated with the controls for navigating the medical device. This can be accomplished in several different ways. The display image and the control can be periodically synchronized. The user can move the control in a preselected direction, for example, up, observe which direction the image on the display screen moves, and mark this direction on the display as the “up” direction. This marking can be conveniently done by moving a cursor or other indicator on the display with a mouse or similar input device. The user positions the cursor or other indicator to indicate the preselected direction and triggers the calibration, for example by clicking the mouse. The computer can then reprocess and reorient the image so that it is intuitively oriented with respect to the control. Alternatively one ormore indicia70, indicating the orientation of the image can be displayed on the display. The physician can use the indicia to properly operate the controller. For example, if the physician wants to move the endoscope in the direction of the “U”indicia70, the physician moves the controller back—regardless of where the “U” indicia is actually located on thedisplay30. Similarly, if the physician wants to move the controller in the direction of the “R”indicia70, the physician moves the controller to the right—regardless of where the “R” indicia is actually located on thedisplay30.

Another way of coordinating the display image with the controls for navigating the medical device is to provide some orientation indicator on the medical device so that the actual orientation can be determined. For example a radiopaque marker can be included on the medical device so that the orientation of the medical device can be determined visually on the display or automatically through image processing. Alternatively, some other system for remotely determining the orientation of the medical device, such as an optic sensor, a magnetic sensor, or an ultrasonic sensor can be used to obtain information about the orientation of the medical device. The computer can process the information about the orientation of the medical device and either re-orient the displayed image, or adjust the operation of the magnetic field control to intuitively coordinate the image and the operation of the control.

The magnetically navigable endoscope system of the present invention can also include one or more sensors80, triggered by contact with an anatomical structure such as the wall of a body lumen or cavity. As shown inFIGS. 10 and 11, these sensors80 can be distributed around the distal end of the endoscope to sense contact anywhere around the circumference of the distal end of the endoscope. The sensors may be, for example a spring contact82 projecting from the exterior sidewall of the endoscope, resiliently biased away from contact84, such that pressure (such as from the endoscope contacting an internal body structure such as the wall of a lumen or cavity) forces the contacts together. A controller, such as a computer, monitors the signals from the sensors and can control the magnetic field generating apparatus to selectively modify the magnetic field to change the orientation of the magnetic body such that the distal end of the endoscope remains in the desired position within the body lumen or cavity in which it is located. For example in some applications, it will be desirable that the endoscope remain substantially centered with a body lumen or cavity, to facilitate its advancement in the lumen or cavity. In other applications, it will be desirable that the endoscope remain in contact with one of the walls of the body lumen or cavity, for example for electrical mapping of the tissue or some other procedure. The system can include an advancing mechanism for advancing the endoscope, and an interlock for preventing operation of the advancing mechanism when a pre-determined number of sensors are triggered.

In a preferred mode of operation, the distal end of the endoscope is localized, for example by manually identifying the distal end of the endoscope on the displays of a bi-planar fluoroscopic imaging system. The physician can easily do this with a computer mouse or other input device, by manipulating a cursor over the end and clicking. Identifying the position of the distal end of the endoscope on two different planar images, uniquely identifies the end of the endoscope in three-dimensional space. The location of the distal end of the endoscope is then registered to a pre-operative image set such as an MR or CT image set. Once the distal end of the endoscope is registered on the pre-operative image set, the physician then identifies a direction on the preoperative image set. The magnetic field generating apparatus then generates the appropriate magnetic field to move (orient and/or advance) the distal end of the endoscope in the identified direction.

Alternatively, after the endoscope is localized, and the position registered on a pre-operative MR or CT image set, the physician could identify inputs a volume over which to move (orient and/or advance) the endoscope. This can be conveniently done by indicating the volume on a preoperative MR or CT image set. The magnetic field generating apparatus then generates the appropriate magnetic field to move (orient and/or advance) the distal end of the endoscope in the specified volume.

The method of the present invention can be used for navigating medical devices virtually anywhere in the body. For example the method of the present invention can be used with ureterscopes, navigating the distal end of the endoscope in the calix of the kidney, as shown inFIG. 12.

Claims

1. A magnetically navigable endoscope system comprising:

an endoscope having a proximal end and a distal end, the distal end having a magnetic body;

a sensor disposed on the distal end of the endoscope that is configured to to detect contact by the distal end of the endoscope with an anatomical structure;

an imaging device which transmits an image, associated with the distal end;

a display component for displaying the image;

a magnetic field generating apparatus for generating a magnetic field to move the magnetic body and thus the distal end of the endoscope;

a controller coordinated with the display for controlling the magnetic field generating apparatus to apply a magnetic field to change the position of the magnetic body and thus the position of the distal end of the endoscope, wherein the controller is configured to respond to the sensor detecting contact by the distal end of the endoscope with an anatomical structure by controlling the magnetic field generating apparatus to orient the distal end towards the center of a body cavity.

2. The magnetically navigable endoscope system according toclaim 1 wherein the controller controls the magnetic field generating apparatus to apply a magnetic field of a specific direction to change the orientation of the magnetic body and thus the orientation of the distal end of the endoscope.

3. The magnetically navigable endoscope system according toclaim 1 wherein the controller controls the magnetic field generating apparatus to apply a magnetic gradient to move the magnetic body and thus the location of the distal end of the endoscope.

4. The magnetically navigable endoscope system according toclaim 1 wherein the controller controls the magnetic field generating apparatus to apply a magnetic field and a magnetic gradient to apply a magnetic field of a specific direction to change the orientation of the magnetic body and to apply a magnetic gradient to move the magnetic body and thus the orientation and location of the distal end of the endoscope.

5. The magnetically navigable endoscope system according toclaim 1 wherein the controller is on the endoscope, adjacent the proximal end.

6. The magnetically navigable endoscope system according toclaim 1 wherein the controller is operable in at least two mutually perpendicular directions, movement in which causes the magnetic field generating apparatus to change the magnetic field to move the distal end of the endoscope in two mutually perpendicular directions.

7. The magnetically navigable endoscope system according toclaim 1 wherein the display includes indicia indicating an orientation of the displayed image, and wherein the controller is operable in at least two mutually perpendicular directions, and movement in the first direction causes the magnetic field generating apparatus to change the magnetic field to move the distal end of the endoscope in a first plane relative to the indicia, and movement in the second direction causes the magnetic field generating apparatus to change the magnetic field to move the distal end of the endoscope in a second plane, perpendicular to the first place.

8. The magnetically navigable endoscope system according toclaim 7 wherein the first plane is aligned with the indicia.

9. The magnetically navigable endoscope system according toclaim 6, wherein the display has vertical and horizontal directions, and wherein the movement of the controller in one of the mutually perpendicular directions causes the magnetic field generating apparatus to change the magnetic field to move the distal end of the endoscope in the vertical direction as displayed on the display, and wherein the movement of the controller in the other of the mutually perpendicular direction causes the magnetic field generating apparatus to change the magnetic field to move the distal end of the endoscope in the horizontal direction as displayed on the display.

10. The magnetically navigable endoscope system according toclaim 9 further comprising a signal processor orienting the image on the display so that the vertically “up” direction of the image is oriented at the top of the display regardless of the actual orientation of the axis of the endoscope.

11-17. (canceled)

18. A magnetically navigable endoscope system comprising:

a sensor disposed on the distal end of the endoscope, which provides a signal when triggered by contact with an anatomical structure;

a component which transmits an image, associated with the distal end;

a two-dimensional display for displaying the image from the image-transmitting component, the display having a vertical and horizontal direction;

a magnetic field generating apparatus for generating a magnetic field to move the magnetic body and thus the distal end of the endoscope; and

a controller for identifying the volume over which to orient the endoscope and controlling the magnetic field generating apparatus to selectively change the magnetic field to change the orientation of the magnetic body and thus the distal end of the endoscope over the specified volume, wherein the controller is configured to respond to a signal indicating contact by the distal end of the endoscope with an anatomical structure by controlling the magnetic field generating apparatus to orient the distal end towards the center of a body cavity.

19. A method of magnetically controlling an endoscope, having a plurality of sequentially aligned magnet bodies disposed on a distal end portion, in body lumens and cavities, the method comprising:

localizing the distal end of an endoscope;

registering the location of the distal end of the endoscope to a pre-operative image set such as an MR or CT;

identifying a direction on the pre-operative image set; and

using a sensor on the distal end of the endoscope to detect contact by the distal end of the endoscope with an anatomical structure;

controlling the magnetic field generating apparatus to move the distal end of the endoscope in the identified direction, wherein the magnetic field generating apparatus may be controlled in response to the sensor detecting contact by the distal end of the endoscope with an anatomical structure by controlling the magnetic field generating apparatus to orient the distal end towards the center of a body cavity.

20. The method of magnetically controlling an endoscope according toclaim 19 wherein the magnetic field generating apparatus generates a magnetic field in the identified direction to orient the distal end of the endoscope in the identified direction.

21. The method of magnetically controlling an endoscope according toclaim 19 wherein the magnetic field generating apparatus generates a magnetic field with a gradient in the identified direction to advance the distal end of the endoscope in the identified direction.

22-29. (canceled)

30. A magnetically navigable endoscope system comprising:

an imaging device which transmits an image, associated with the distal end;

a plurality of sensors triggered by contact with the wall of a body lumen or cavity, distributed around the distal end;

a two-dimensional display for displaying the image from the imaging device, the display having a vertical and horizontal direction;

a magnetic field generating apparatus for generating a magnetic field to orient the magnetic body and thus the distal end of the endoscope;

a computer which monitors feedback of the wall contact sensors and adjusts the magnetic field generating apparatus to selectively modify the magnetic field to change the orientation of the magnetic body such that the endoscope is automatically positioned within the body lumen or cavity.

31. The system according toclaim 30 wherein the computer that monitors the feedback of the wall contact sensors adjusts the magnetic field generating apparatus to selectively modify the magnetic field to position the endoscope in generally the center of the body lumen or cavity.

32. The system according toclaim 30 wherein the computer that monitors the feedback of the wall contact sensors adjusts the magnetic field generating apparatus to selectively modify the magnetic field to position the endoscope generally adjacent a selected wall of the body lumen or cavity.

33. The system according toclaim 30 further comprising an advancing mechanism for advancing the endoscope.

34. The system according toclaim 33 further comprising an interlock for preventing operation of the advancing mechanism when a predetermined number of wall-sensors are triggered.

35-39. (canceled)