US20080300586A1

Movatterモバイル変換

Info

Publication number: US20080300586A1
Application number: US12/222,157
Authority: US
Inventors: Roni Zvuloni
Original assignee: Galil Medical Ltd
Current assignee: Galil Medical Ltd
Priority date: 2000-10-24
Filing date: 2008-08-04
Publication date: 2008-12-04
Also published as: US20050224085A1; US20020068929A1; US7407501B2

Abstract

An apparatus for compressing a gas and its uses are disclosed. The apparatus comprises a fixed-volume container having a hollow and a moveable element subdividing said hollow into a first variable-volume portion and a second variable-volume portion, the second variable-volume portion having an opening for introducing therein a hydraulic and/or pneumatic fluid under pressure, for causing an increase in the volume of said second variable-portion by moving said moveable element, thereby, consequently, decreasing the volume of the first variable-volume portion and compressing a gas contained therein.

Description

This is a continuation of U.S. patent application Ser. No. 09/987,689, filed Nov. 15, 2001, which is a continuation-in-part of U.S. patent application Ser. No. 09/860,486, filed May 21, 2001, now U.S. Pat. No. 6,706,037, which claims the benefit of priority from U.S. Provisional Patent Application No. 60/242,455, filed Oct. 24, 2000, now expired.

FIELD AND BACKGROUND OF THE INVENTION

The present invention relates to apparatus and method for compressing and/or re-compressing gas and further to the use of in situ gas compression as a source of compressed gas to a compressed gas utilizing application, such as a cryoablation apparatus.

Many methods are known in the art for mechanically compressing (pressurizing) gas, for storing compressed (pressurized) gas in containers, for transporting compressed gas to sites where the compressed gas is to be used, and for utilizing compressed gasses for a variety of purposes in a variety of utility applications.

Gas compression is most typically accomplished using single stage or multiple stage reciprocating piston systems powered by independent power sources such as electric motors or internal combustion engines.

Alternatively, low and medium pressure gasses are sometimes raised to a higher pressure via the use of what is known in the art as “booster” pumps. One popular form of a booster pump does not require external power sources. In these pumps the pressure of the input gas itself is applied over the surface of a large area piston which, by mechanical linkage, induces movement in a small area piston. The small area piston is used to compress a portion of the input gas to a higher level of compression.

In many usages of compressed gas, heavy-duty equipment for pressurizing gas is located at a gas supply facility distant from the utilization site itself. Pressurized gas is typically transported to the utilization site in pressurized gas containers such as gas cylinders. At the utilization site, the gas containers are coupled to the application that utilizes the compressed gas. During utilization, the gas containers are gradually emptied until the residual pressure of the gas in the containers becomes too low for the particular application. The containers are then typically uncoupled from the application and returned to the gas supply facility, where they are refilled and re-pressurized.

For many industrial, domestic, recreational, and other uses, these prior art methods are adequate. With respect to some applications, however, limitations and disadvantages of these prior art methods are apparent.

Reciprocating piston compression systems typically require lubrication, and volatilization of the lubricants can compromise the purity of the compressed gas.

Thus there is a widely recognized need for, and it would be highly advantageous to have, a method and apparatus for gas compression not involving the large rapid and continuous mechanical movements typical of reciprocating piston systems, and not requiring lubrication of the moving parts.

The phrases “medium pressure” and “medium pressure gas” are used herein to refer to gasses in a range of pressures customarily used in industrial processes, and customarily supplied by industrial supply sources. Compressed argon, used for a variety of industrial purposes, is typically supplied at a pressure of about 2500 PSI. For argon, pressures in this range are referred to herein as “medium” pressures.

The phrases “high pressure” and “high pressure gas” are used herein to refer to gasses in a range of pressures above medium pressure. Various compressed gas utilizing applications require the use of high pressure gas. Compressed argon for use in cryosurgery applications, for example, is typically required to be in the range of 3000-4500 PSI and above.

The prior art methods of supplying high pressure gas to high pressure gas applications are problematic in several respects.

One practical problem encountered in using high pressure gas in applications is that some high pressure gasses are simply not commercially available in many regions of the world. This problem exists even in some highly industrialized regions. In Japan, for example, argon gas, which is used in welding and other industrial processes, is available in popular industrial medium-pressure concentrations, yet high pressure argon gas is not commercially available in Japan. A Japanese utilization site, such as a cryosurgery site, requiring high pressure argon gas, must import this gas from outside the country.

A second practical problem in the use of prior art methods for supplying high pressure gas to a high pressure gas application is that transporting high pressurize gas can be inconvenient and/or dangerous. High pressure gas requires containers that are stronger and heavier than containers used for housing moderate pressurize gas. Transportation is more problematic as well. It may be considered more dangerous to transport high pressurize gas by air transportation, for example.

Thus, there is a widely recognized need for, and it would be highly advantageous to have, a method and apparatus for supplying high pressurize gas to a high pressurize gas application, using gas from popularly available medium pressure sources. Such an apparatus and method would overcome the practical difficulties of acquiring high pressure gas and the practical difficulties of transporting high pressurize gas.

A third problem in the use of prior art methods for supplying gas to high pressure gas applications is that a significant portion of gas so supplied cannot be used for its intended purpose. When gas is supplied in pressurized containers connected directly to the utilization mechanisms, the pressure of the gas in the supplied container gradually falls as the gas is used. Gas pressure in the container eventually drops to a point where it is lower than the minimum pressure required for the high-pressure application. At this point, considerable gas still remains in the container. This situation has the practical disadvantage that the container must then be returned to the gas supplier for refilling while still containing a significant quantity of unused gas, which is inconvenient. It also has the commercial disadvantage that in many cases suppliers do not credit their customers for the returned gas, so that the customer often pays for gas which was supplied to him but which he could not use.

There is, thus, also a widely recognized need for, and it would be highly advantageous to have, a method and apparatus for utilizing compressed gas which enables full use of all, or at least substantially most, of the gas supplied in a gas supply container.

There are, of course, some compressed gas utilizing applications in which re-pressurization and re-use of gasses is impractical. In some uses of compressed gas the cost of pressurizing and transporting the gas is relatively greater than the cost of manufacturing or isolating the gas. Pressurized air provides an example. For such gasses there would be little point in recycling the gas after use. In other cases, a pressurized gas is chemically transformed during utilization. Flammable gasses used for combustion are an example. Here too, recycling the gas is not generally practical.

In some applications, however, recycling is possible and in many cases eminently desirable. This is the case, for example, in compressed gas utilizing applications utilizing a gas which is rare, or is expensive to produce or to isolate, and in which the gas is not chemically transformed when utilized. A cryosurgery system utilizing krypton gas is an example of such an application.

Cryosurgery systems based on Joule-Thomson heat exchangers (also commonly referred to as Joule-Thomson devices) use compressed gas for heating and intense cooling of therapeutic cryoprobes used to ablate tissues within the body. The design of such applications is based on the fact that a compressed gas changes temperature as it moves from a region of high pressure to a region of low pressure. The gasses used do not enter into chemical interactions with their environment, they simply expand and contract, liquefy and evaporate.

Krypton presents advantages over the more popular argon gas for this to application. For reasons connected with the physical characteristics of the gas, a krypton-based cryosurgery system can function at a lower pressure than an argon-based system, consequently is easier to build, maintain, and use. Yet krypton is considerably more expensive than argon, on the order of one hundred times more expensive in today's market. In a prior art system, where the compressed gas used in cryosurgery is, after decompression through use, simply vented to the atmosphere, use of the otherwise desirable krypton gas would be wasteful and expensive.

Thus, there is a widely recognized need for, and it would be highly advantageous to have, system and method for re-pressurizing and reusing gasses utilized in compressed gas utilizing applications, cryosurgery applications in particular.

The limitations and disadvantages of the prior art in the field of gas compression and the use of compressed gasses are particularly clear in the context of cryosurgery. Various medical conditions require the ablation of unhealthy tissues within the body. Techniques for cryoablation developed in recent years present various advantages over other ablation techniques, in particular the advantage of causing less damage to healthy tissues in proximity to the tissues whose removal or destruction is desired. Invasive surgical procedures require cutting or destroying tissues between the exterior of the body and the particular site whose destruction is desired. Less invasive procedures have been used, which bring about the destruction of selected tissues using probes which penetrate to the area to be operated and destroy the selected tissue by transferring energy to those tissues. RF energy, light (laser) energy, microwave energy, and high-frequency ultra-sound energy have been used in this context. However all such methods have the common disadvantage that while they raise the temperature of the tissues whose destruction is intended, they transfer heat to healthy tissues as well, causing their destruction, partial destruction, or functional impairment. Moreover, in some cases tissues exposed to thermal energy or other forms of energy that raise their temperatures secrete substances toxic to adjacent healthy tissues. For these and other reasons, cryoablation has become a popular method for certain types of ablation procedures. Examples are the treatment of prostate tumors and of benign prostate hyperplasia (BPH), and the creation of trans-myocardial channels to effect trans-myocardial revascularization.

According to a popular cryosurgical methodology, highly compressed gas is employed to cool and to heat surgical probes used for cryoablation of tissues. A preferred technology for effecting cryoablation involves the use of Joule-Thomson heat exchangers (also popularly known as “Joule-Thomson devices”) for cooling and for heating of cryoprobes at the site of tissues to be cryoablated. U.S. Pat. No. 6,142,991 to Schatzberger and U.S. Pat. No. 5,978,697 to Maytal, et al., provide examples of systems using such devices.

To cool a cryosurgical apparatus utilizing a Joule-Thomson heat exchanger, a gas such as argon, nitrogen, air, krypton, CF₄, xenon, N₂O, or a mixture of similar gasses, under high pressure, is allowed to pass through an orifice into a chamber where the gas can expand. Expansion of the gas causes it to cool and may cause it to liquefy, or further liquefy. This process cools the chamber. Gasses which cool such a chamber after passing through such an orifice from an area of high pressure to an area of lower pressure are referred to herein as “cooling gasses.” If the chamber is constructed of thermally conductive material such as a metal, cooling the chamber cools materials in proximity to the chamber as well. Cryoprobes for cryoablation are typically designed and constructed according to this principle. Cryoprobes using expansion of a high-pressure cooling gas through a Joule-Thomson orifice into a chamber constructed of thermally conductive material are used to cool body tissues in close proximity to the cryoprobe, to effect cryoablation.

Cryosurgical procedures sometimes also require heating of cryoprobes. Tissues undergoing cryoablation tend to adhere to the cold cryoprobe. Heating the cryoprobe subsequent to cryoablation causes melting at areas of contact between the cryoprobe and the tissues, thereby eliminating adherence of the tissues to the cryoprobe and allowing the cryoprobe to be easily removed from the cryoablation site. Cryoprobes may be heated, as well as cooled, using a Joule-Thomson heat exchanger. High-pressure helium or a similar gas passing through a Joule-Thomson orifice and expanding in a chamber, heats the chamber. Gasses which heat such a chamber after passing through such an orifice from an area of high pressure to an area of lower pressure are referred to herein as “heating gasses.” If the chamber is constructed of thermally conductive material such as a metal, heating the chamber has the effect of heating materials in proximity to the chamber. This effect is used in the construction and utilization of cryoprobes to melt material adjacent to a cryoprobe subsequent to cryoablation, thereby enabling disengagement of the cryoprobe from the operated tissues.

Cryosurgical equipment using Joule-Thomson heat exchangers and utilizing popular and easily available cooling gasses, such as argon, require for their efficient operation a source of high pressure cooling gas, typically in the pressure range of 3000 PSI to 4500 PSI.

The need for high pressure gasses for efficient operation of cryosurgical equipment raises the several practical problems discussed hereinabove. Argon, for example, is a preferred gas for cooling in cryosurgical equipment based on Joule-Thomson devices. High pressure argon is more expensive than argon at standard industrial pressures, and in some locations, such as Japan, high pressure argon is not available at all. Argon can of course be purchased from standard industrial supply sources, but only at the medium pressures customarily used in industrial processes, typically around 2500 PSI. The pressure of easily commercially available industrial compressed argon is lower than the pressures required for efficient cooling of cryosurgical equipment using argon in a Joule-Thomson heat exchanger.

Thus, there is a widely recognized need for, and it would be highly advantageous to have, a method and apparatus for cryoablation wherein containers of gas pressurized to moderate pressure, such as are available from standard industrial sources of supply, are used to supply gas to a cryosurgery apparatus requiring gas of high pressure to effect cryogenic cooling.

An additional problem connected with the high-pressure requirements of cryosurgery is that even in regions of the world where high-pressure cooling and heating gasses are commercially available, their utilization is awkward and expensive. Gasses supplied in a high-pressure container can be utilized only until the pressure of gas in the container falls to the minimum pressure usable in cryosurgery. According to the methods of prior art, once pressure in a gas supply container falls below the minimum pressure required for cryosurgery, the gas supply container can no longer be utilized as a cryosurgery gas source, despite the fact that a considerable amount of cooling (or heating) gas may yet remain in the tank. If for example a cryoprobe requires a pressure of 4500 PSI (a typical figure) and a full container of gas is initially pressured to 6000 PSI, then only 25% of the supplied gas can be used for cryosurgery. As soon as more than one fourth of the gas initially contained in the container has been used, pressure in the container falls below the 4500 PSI minimum required by such a cryoprobe. In the case of a cryoprobe operating at 3250 PSI the situation is only slightly better: only approximately 46% of the gas contained in a 6000 PSI container can be used before pressure in the container falls below the minimum pressure required for operation of the cryoprobe.

Once pressure in a gas supply container falls below the minimum required for operation of a cryoprobe, the container must be returned to a gas supplier re-filling. In practice, some suppliers credit users for the unused gas returned to them in such a container. Other suppliers do not. In either case, the expense and bother occasioned by the necessity of switching containers, and the necessity of returning containers to a supplier for refilling while they yet contain substantial amounts of useful gas, are significant disadvantages of cryosurgical equipment and procedures, according to the known methods of prior art.

Thus, it would be desirable and advantageous to have a method and system for utilization of compressed gas in cryosurgery, and in similar applications, permitting utilization of substantially all or most of the contents of each container of supplied gas.

Prior art cryosurgery systems also suffer from the disadvantage that they do not re-use pressurized gas. The advantages (lower pressure requirements) of krypton gas over argon gas for use in cryosurgery systems are well known. Yet, it is largely impractical to use Krypton gas in prior art cryogenic systems, wherein the cooling gas is used for cryogenic cooling only once, and then is allowed to escape to the atmosphere.

Thus, there is a widely recognized need for, and it would be highly advantageous to have, an apparatus and method for re-pressurizing and re-utilizing the pressurized gasses in some compressed gas systems, particularly systems which utilize gasses that are rare or expensive to produce or isolate, and in which the gasses are not chemically altered when used. In cryosurgery there is a particular need for such methods and systems.

SUMMARY OF THE INVENTION

According to one aspect of the present invention there is provided an apparatus for compressing a gas, including a fixed-volume container having a hollow and a moveable element subdividing the hollow into a first variable-volume portion and a second variable-volume portion, the second variable-volume portion having an opening for introducing therein a hydraulic and/or pneumatic fluid under pressure, for causing an increase in the volume of the second variable-portion by moving the moveable element, thereby, consequently, decreasing the volume of the first variable-volume portion and compressing a gas contained therein.

According to further features in preferred embodiments of the invention described below, the first variable-volume portion is designed and constructed so as to be couplable during a first phase of operation to a mechanism for introducing a gas into the first variable-volume portion, and to be couplable during a second phase of operation to a mechanism for transporting a compressed gas from the first variable-volume portion to a compressed gas utilizing application, for supplying a compressed gas to said compressed gas utilizing application.

According to still further features in the described preferred embodiments, the first variable-volume portion is coupled during the first phase of operation to a source of a gas, and is coupled during a second phase of operation to a mechanism for transporting a compressed gas from the first variable-volume portion to a compressed gas utilizing application.

According to still further features in the described preferred embodiments, the second variable-volume portion is designed and constructed to be couplable during the second phase of operation to a source of hydraulic and/or pneumatic fluid under pressure.

According to still further features in the described preferred embodiments, the second variable-volume portion is coupled during the second phase of operation to a source of hydraulic and/or pneumatic fluid under pressure.

According to still further features in the described preferred embodiments, the moveable element is constructed of a rigid material.

According to still further features in the described preferred embodiments, the moveable element is a piston.

According to still further features in the described preferred embodiments, the moveable element is at least partially constructed of a flexible material, such as an elastomer, or a reinforced rubber.

According to still further features in the described preferred embodiments, the moveable element is a diaphragm.

According to still further features in the described preferred embodiments, the moveable element is a bladder. The first variable-volume portion forms a portion of said hollow and may be defined by the bladder, or it may be defined by the fixed volume container and outside the bladder.

According to another aspect of the present invention there is provided a method for compressing a gas, utilizing a fixed-volume container having a hollow and a moveable element subdividing the hollow into a first variable-volume portion and a second variable-volume portion, including the steps of introducing a gas into the first variable-volume portion of the hollow during a first phase of operation; and introducing a hydraulic and/or pneumatic fluid under pressure into the second variable-volume portion of the hollow during a second phase of operation, thereby increasing the volume of the second variable-volume portion by moving the moveable element, thereby, consequently decreasing the volume of the first variable-volume portion and compressing the gas contained therein.

According to yet another aspect of the present invention there is provided a method for supplying a compressed gas to a compressed gas utilizing application, utilizing a fixed-volume container having a hollow and a moveable element subdividing the hollow into a first variable-volume portion and a second variable-volume portion, including the steps of introducing a gas into the first variable-volume portion of the hollow during a first phase of operation; introducing a hydraulic and/or pneumatic fluid under pressure into the second variable-volume portion of the hollow during a second phase of operation, thereby increasing the volume of the second variable-volume portion by moving the moveable element, thereby consequently decreasing the volume of the first variable-volume portion and compressing the gas contained therein, and transferring a gas during the second phase of operation from the first variable-volume portion of the hollow to the compressed gas utilizing application.

According to still another aspect of the present invention there is provided a compressed gas utilization system including a first gas compression apparatus for compressing a gas, including a fixed-volume container having a hollow and a moveable element subdividing the hollow into a first variable-volume portion and a second variable-volume portion, the second variable-volume portion having an opening for introducing therein a hydraulic and/or pneumatic fluid under pressure, for causing an increase in the volume of the second variable-volume portion by moving the moveable element, thereby consequently decreasing the volume of the first variable-volume portion and compressing a gas contained therein, the system further including a compressed gas utilizing application utilizing compressed gas, and a first mechanism for transporting a compressed gas from the first variable-volume portion of the first gas compression apparatus to the compressed gas utilizing application.

According to further features in preferred embodiments of the invention described below, the first variable-volume portion of the first gas compression apparatus is coupled during a first phase of operation to a mechanism for introducing a gas into the first variable-volume portion of the first gas compression apparatus, and the first variable-volume portion of the first gas compression apparatus is coupled during a second phase of operation to the mechanism for transporting a compressed gas from the first variable-volume portion of the first gas compression apparatus to the compressed gas utilizing application.

According to still further features in the described preferred embodiments, the system further includes a second gas compression apparatus including a fixed-volume container having a hollow and a moveable element subdividing the hollow into a first variable-volume portion and a second variable-volume portion, the second variable-volume portion having an opening for introducing therein a hydraulic and/or pneumatic fluid under pressure, for causing an increase in the volume of the second variable-volume portion by moving the moveable element, thereby consequently decreasing a volume of the first variable-volume portion and compressing a gas contained therein, and further includes a second mechanism for transporting a compressed gas from the first variable-volume portion of the second gas compression apparatus to the compressed gas utilizing application.

According to still further features in the described preferred embodiments, the system is designed and constructed so as to enable the first gas compression apparatus to be in the first phase of operation while the second gas compression apparatus is in the second phase of operation, and the first gas compression apparatus to be in the second phase of operation while the second gas compression apparatus is in the first phase of operation.

According to still further features in the described preferred embodiments, the system is designed and constructed so that the first gas compression apparatus is in the first phase of operation when the second gas compression apparatus is in the second phase of operation, and the first gas compression apparatus is in the second phase of operation when the second gas compression apparatus is in the first phase of operation.

According to an additional aspect of the present invention there is provided a cryosurgery system including a first gas compressor for compressing gas, a cryoablation apparatus utilizing compressed gas, and a mechanism for transporting compressed gas from the gas compressor to the cryoablation apparatus during use.

According to further features in the described preferred embodiments, the cryoablation apparatus includes a Joule-Thomson heat exchanger for cooling a portion of the cryoablation apparatus.

According to still further features in the described preferred embodiments, the system includes a mechanism for re-pressurizing a gas depressurized by use in the Joule-Thomson heat exchanger.

According to still further features in the described preferred embodiments, the system further includes a mechanism for transporting a gas depressurized by use in a Joule-Thomson heat exchanger from the cryoablation apparatus to the gas compressor. The mechanism may include a second gas compressor, and may also include a gas reservoir.

According to still further features in the described preferred embodiments, the first gas compressor includes a fixed-volume container having a hollow and a moveable element subdividing the hollow into a first variable-volume portion and a second variable-volume portion, the second variable-volume portion having an opening for introducing therein a hydraulic and/or pneumatic fluid under pressure, for causing an increase in a volume of the second variable-volume portion by moving the moveable element, thereby consequently decreasing a volume of the first variable-volume portion and compressing a gas contained therein.

According to still further features in the described preferred embodiments, the first variable-volume portion of the first gas compression apparatus is coupled during a first phase of operation to a mechanism for introducing a gas into the first variable-volume portion of the first gas compression apparatus, and the first variable-volume portion of the first gas compression apparatus is coupled during a second phase of operation to the mechanism for transporting a compressed gas from the first variable-volume portion of the first gas compression apparatus to the compressed gas utilizing application.

According to yet an additional aspect of the present invention there is provided a method for cryosurgery, involving in situ compression of gas, including using a first in situ gas compressor to compress a gas, thereby transforming the gas into a first compressed gas at a first gas pressure, transferring the first compressed gas at the first gas pressure from the first gas compressor to a cryoablation apparatus utilizing the first compressed gas at the first gas pressure; and using the cryoablation apparatus to perform cryoablation, thereby creating a decompressed gas at a second gas pressure.

According to further features in the described preferred embodiments, the method further includes the steps of transferring the depressurized gas at the second gas pressure to the first gas compressor, for recompression and reuse, and recompressing and reusing the depressurized gas.

According to still further features in the described preferred embodiments, the method further includes the steps of transferring said depressurized gas at the second gas pressure to a second gas compressor, for recompression and reuse, and recompressing and reusing the depressurized gas.

The present invention successfully addresses the shortcomings of the presently known configurations by providing a method and apparatus for compressing gas which does not depend on a rapidly moving reciprocating piston system, and therefore does not require lubrication which might contaminate the purity of the compressed gas.

The present invention further successfully addresses the shortcomings of the presently known configurations by providing a method and apparatus for supplying gas of substantially constant pressure to a compressed-gas application, using standard cylinders of compressed gas as a source of gas.

The present invention further successfully addresses the shortcomings of the presently known configurations by providing a method and apparatus for supplying gas of high pressure to an application using high-pressure compressed gas, utilizing standard cylinders of moderate pressure compressed gas as a source of gas. In particular, the present invention successfully addresses the shortcomings of the presently known configurations of cryosurgery systems by providing a method and apparatus for cryoablation that efficiently uses gas for Joule-Thomson cooling (or heating) from a gas source whose initial pressure is lower than that required for efficient operation of a Joule-Thomson device, and is in the range of gas pressures available from standard industrial gas sources. This is in sharp distinction to methods of prior art, which require specialized high-pressure gas sources for operation of a cryosurgery device.

The present invention further successfully addresses the shortcomings of the presently known configurations by providing a method and apparatus for supplying gas of high pressure while nevertheless utilizing substantially most or all of the compressed gas supplied in standard compressed gas cylinders. In particular, the present invention successfully addresses the shortcomings of the presently known configurations of cryosurgery systems by providing a method and apparatus for cryoablation in which substantially most of the cooling gasses supplied in a tank of cooling gas can be used for cooling a cryoprobe, and substantially most of the heating gasses supplied in a tank of heating gas can be used for heating a cryoprobe. This is in distinction to methods of prior art is wherein a substantial portion of the contents of each tank of cooling gas cannot be used for cooling a cryoprobe, and a substantial portion of the contents of each tank of heating gas cannot be used for used for heating a cryoprobe.

The present invention further successfully addresses the shortcomings of the presently known configurations by providing a method and apparatus for re-pressurizing and reusing gas supplied from a high-pressure source and depressurized by utilization in an application. In particular, the present invention successfully addresses the shortcomings of presently known configurations of cryosurgery systems by providing a method and apparatus for the practical and economical use of rare and expensive gasses in such systems through the use of method and apparatus for re-pressurizing and reusing such gasses.

BRIEF DESCRIPTION OF THE DRAWINGS

The invention is herein described, by way of example only, with reference to the accompanying drawings. With specific reference now to drawings in detail, it is stressed that the particulars shown are by way of example and for purposes of illustrative discussion of the preferred embodiments of the present invention only, and are presented in the cause of providing what is believed to be the most useful and readily understood description of the principles and conceptual aspects of the invention. In this regard, no attempt is made to show structural details of the invention in more detail than is necessary for a fundamental understanding of the invention, the description taken with the drawings making apparent to those skilled in the art how the several forms of the invention may be embodied in practice.

In the drawings:

FIG. 1 is a gas compression apparatus utilizing a piston, according to the present invention;

FIG. 2 is a gas compression apparatus utilizing a diaphragm, according to the present invention;

FIG. 3 is a gas compression apparatus utilizing a bladder, according to the present invention;

FIG. 4 is an alternative construction of a gas compression apparatus utilizing a bladder, according to the present invention;

FIG. 5 is an exemplary compressed gas utilization system in the form of a cryosurgery apparatus utilizing in situ compressed gas, according to the present invention;

FIG. 6 is a compressed gas delivery module, according to the present invention;

FIG. 7 is a compressed gas utilization system incorporating a rechargeable gas compression apparatus, according to the present invention; and

FIG. 8 is a compressed gas utilization system utilizing a plurality of gas compression apparati.

DESCRIPTION OF THE PREFERRED EMBODIMENTS

The present invention is of apparatus and method for compressing and/or re-compressing gas which can be used for in situ gas compression as a method of supplying compressed gas to a compressed gas utilizing application, such as a cryoablation apparatus. More specifically, the present invention can be used to compress a gas for use in a compressed gas utilizing application. The present invention can further be used to raise the pressure of a compressed gas, to thereby supply high pressure gas to a compressed gas utilizing application using medium pressure gas sources. It can further be used to supply compressed gas at a constant selected pressure to a compressed gas utilizing application. It can further be used to supply compressed gas to a compressed gas utilizing application, while utilizing all or substantially most of the gas supplied in conventional gas cylinders or similar containers.

In one particular and presently preferred embodiment, the present invention is used to supply high pressure gas to a cryosurgery apparatus and enables re-pressurization and re-use of a compressed gas used in a Joule-Thomson heat exchanger for heating and cryogenic cooling.

To enhance clarity of the following descriptions, the following terms and phrases will first be defined:

The terms “compression” and “pressurization” are used herein interchangeably. A “compressed gas” is a pressurized gas, a gas held under a pressure higher than atmospheric pressure.

A “compressed gas utilizing application” is a device, apparatus, or system utilizing compressed gas while operating.

The phrase “medium pressure” is used herein to refer to a degree of pressurization in or near the range of pressurization typical of gasses sold by industrial supply sources when supplying gasses used for common industrial purposes. By way of example, compressed argon is commonly sold by industrial supply sources pressurized to about 2500 PSI. It is noted that other particular types of gasses may be typically available in other pressure ranges. The term “medium pressure”, as used herein, is not limited to a particular pressure, but is used generally to refer to a pressure range typically commercially available for each type of gas, and is contrasted with “high pressure” defined hereinbelow.

The phrase “high pressure” is used herein to refer to a degree of pressurization higher than the range of pressurization typical of gasses sold by industrial supply houses when supplying gasses used for common industrial purposes. By way of example, compressed argon used in cryosurgery apparatus is typically pressurized to the range of 3000-4500 PSI, which range, for argon, is referred to herein as a high pressure, and argon gasses at such pressure are referred to herein as high pressure gasses. The term “high pressure” as used herein is not, however, limited to that particular pressure range. Rather, the term “high pressure” is used herein to refer to that pressure which, for any particular type of gas, is higher than the “medium pressure” at which that particular type of gas is typically easily and economically commercially available.

The phrase “low pressure” is used herein to refer to a degree of pressurization lower than the range of pressurization typical of gasses sold for use in compressed gas utilizing applications. A gas may be at “low pressure”, and yet be at a pressure higher than atmospheric pressure.

The phrase “depressurized gas” and the term “depressurization” are used herein to refer particularly to the pressurization state of a gas which has been used by a compressed gas utilizing application, and which is consequently at a low pressure subsequent to having been so used.

The phrase “Joule-Thomson heat exchanger” refers, in general, to any device used for cryogenic cooling or for heating, in which a gas is passed from a first region of the device, wherein it is held under higher pressure, to a second region of the device, wherein it is enabled to expand to lower pressure. Such devices are also commonly referred to as Joule-Thomson devices. A Joule-Thomson heat exchanger may be a simple conduit, or it may include an orifice through which gas passes from the first, higher pressure, region of the device to the second, lower pressure, region of the device. The expansion of certain gasses (referred to herein as “cooling gasses”) in a Joule-Thomson heat exchanger, when passing from a region of higher pressure to a region of lower pressure, causes these gasses to cool and may cause them to liquefy, creating a cryogenic pool of liquefied gas. This process cools the Joule-Thomson heat exchanger itself, and also cools any thermally conductive materials in contact therewith. The expansion of certain other gasses (referred to herein as “heating gasses”) in a Joule-Thomson heat exchanger causes the gasses to heat, thereby heating the Joule-Thomson heat exchanger itself and also heating any thermally conductive materials in contact therewith.

The principles and operation of a gas compression apparatus and of a compressed gas utilization system according to the present invention may be better understood with reference to the drawings and accompanying descriptions.

Before explaining at least one embodiment of the invention in detail, it is to be understood that the invention is not limited in its application to the details of construction and the arrangement of the components set forth in the following description or illustrated in the drawings. The invention is capable of other embodiments or of being practiced or carried out in various ways. Also, it is to be understood that the phraseology and terminology employed herein is for the purpose of description and should not be regarded as limiting.

Referring now to the drawings,FIG. 1 presents a preferred embodiment of a gas compression apparatus according to the present invention. For convenience and clarity, a gas compression apparatus according to the present invention will be referred to hereinbelow as a “bi-pump”18.

InFIG. 1,bi-pump18 comprises acontainer20, rigidly constructed of a strong material such as a metal and designed to withstand high pressures.Container20 is optionally surrounded by a thermally insulatinglayer16.Container20 has a hollow22 and amoveable element28.Moveable element28 serves to divide hollow22 into a first variable-volume portion, referred to herein asgas portion24, and a second variable-volume portion, referred to herein asfluid portion26.

Gas portion

24 is for receiving, holding, and compressing a gas. A gas to be compressed is introduced intogas portion24 through agas input coupling46.Gas input coupling46 is forcoupling bi-pump18 to a source of gas which is to undergo compression. The input gas introduced intobi-pump18 may be an uncompressed gas, or may be a pressurized gas at a pressure lower than a pressure which is desired to be obtained, e.g., for use in a compressedgas utilizing application42. Agas output coupling40 is provided forcoupling gas portion24 to compressedgas utilizing application42, or to some other destination for the compressed gas. Thus, compressed gas may be transferred to compressedgas utilizing application42 or to any other destination throughgas output coupling40. Optionally,gas input coupling46 includes agas input valve41 for controlling flow of input gas. Optionally,gas output coupling40 includes agas output valve43 for controlling flow of output gas.

The gas introduced intogas portion24 can be any gas, including, but not limited to argon, nitrogen, air, krypton, CF₄, N₂O, CO₂, and helium.

Fluid portion

26 is for receiving and holding a pressurizingfluid32. Pressurizingfluid32 entersfluid portion26 through a pressurizingfluid input coupling48, and can be drained from the apparatus through pressurizingfluid output coupling50.

During a first phase of operation, a gas is introduced intogas portion24 throughinput gas coupling46. Also during the first phase of operation, pressurizingfluid32 present influid portion26 as a result of previous iterations of the process is allowed to drain fromfluid portion26 through pressurizingfluid output coupling50.

During a second phase of operation, pressurizingfluid32 is introduced intofluid portion26 in order to exert pressure onmoveable element28. Pressurizingfluid32 is any fluid capable of exerting such pressure, such as a hydraulic fluid such as oil or water, or such as a pneumatic fluid such as a compressed gas, or such as a mixture of a hydraulic fluid such as oil mixed with a pneumatic fluid such as a compressed gas. Use of a hydraulic liquid as pressurizingfluid32 is the currently preferred choice in preferred embodiments of the invention.

During a second phase of operation,fluid pressurizer33

supplies pressurizing fluid

32 under pressure. Pressurized pressurizingfluid32 is introduced intofluid portion26 through pressurizingfluid input coupling48. In a preferred embodiment,fluid pressurizer33 is ahydraulic unit35, capable of supplying a hydraulic liquid at a selected pressure, according to methods well known in the art. Pressurizingfluid32 exerts pressure onmoveable element28, causingmoveable element28 to move.

The movement ofmoveable element28 in response to pressure exerted by pressurizingfluid32 causes the volume offluid portion26 of hollow22 to increase.Gas portion24 andfluid portion26 share the same fixed total volume, which is the volume of hollow22 exclusive of the volume ofmoveable element28, which in preferred embodiments is relatively non-compressible.

Consequently, an increase in the volume offluid portion26 coincides with a decrease in the volume ofgas portion24. Thus, the movement ofmoveable element28 forces the gas contained ingas portion24 into a smaller volume, and the gas is thereby compressed proportionally.

Moreover,moveable element28 moves relatively freely, hencemoveable element28 will tend to move in such a manner as to equalize pressure betweengas portion24 andfluid portion26. In consequence, changes in pressure of pressurizingfluid32 as supplied byfluid pressurizer33 are rapidly reflected as corresponding changes in pressure of the gas being compressed withingas portion24. Thus, pressure of gas compressed ingas portion24 is substantially controlled by pressure of pressurizingfluid32.Fluid pressurizer33 is capable of supplying fluid at a selected pressure, using techniques well known to one schooled in the art. Control of output pressure offluid pressurizer33 constitutes control of pressure of gas compressed bygas portion24. Thus, bi-pump18 can compress gas to a selected and controlled pressurize.

Thus, according to another aspect of the present invention there is provided a method for compressing a gas, utilizing a fixed-volume container having a hollow and a moveable element subdividing the hollow into a first variable-volume portion and a second variable-volume portion. The method according to this aspect of the invention is effected by introducing a gas into the first variable-volume portion of the hollow during a first phase of operation; and thereafter introducing a hydraulic or pneumatic fluid under pressure into the second variable-volume portion of the hollow during a second phase of operation, thereby increasing a volume of the second variable-volume portion by moving the moveable element, thereby, consequently decreasing a volume of the first variable-volume portion and compressing the gas contained therein.

According to methods of use in currently preferred embodiments of the present invention, during a second phase of operation, compressed gas fromgas portion24 is allowed to pass throughgas output coupling40, from where it can serve as a supply of compressed gas to compressedgas utilizing application42 or other needs.

Gas input coupling

46 andgas output coupling40 are shown as different couplings, yet in an optional construction they may be a combined input/output gas coupling. Similarly, pressurizingfluid input coupling48 and pressurizingfluid output coupling50 are shown as different couplings, yet in an optional construction they may be a combined pressurizing fluid input/output coupling.

Moveable element

28 will either move rigidly, changing position withincontainer20, or else it will move elastically, changing shape. An example of rigid movement is presented by the embodiment ofFIG. 1. Examples of elastic movement are given by the embodiments presented byFIGS. 2,3 and4.

In a preferred embodiment of the present invention, specifically shown inFIG. 1,moveable element28 is constructed of a rigid material, such as a metal or a hard non-deformable polymeric material or composite material. In thispreferred embodiment container20 is cylindrical, andmoveable element28 is designed and constructed in the form of apiston34.Piston34 is able to move longitudinally withincylindrical container20. During a second phase of operation, when pressurized pressurizingfluid32 is introduced intofluid portion26 it exerts pressure onpiston34.Piston34 responds to the pressure by moving longitudinally incontainer20 towardsgas portion24. The volume ofgas portion24 is thereby reduced and the gas contained therein is compressed.

FIGS. 2,3 and4 present preferred embodiments in which at least a part ofmoveable element28 is constructed of flexible material, such as a reinforced rubber or an elastomer.

In a preferred embodiment of the present invention shown inFIG. 2,moveable element28 is adiaphragm36.Diaphragm36 is anchored at a fixed in position withincontainer20, yetflexible area38 ofdiaphragm36 is constructed of an elastic material. During the second phase of operation, high-pressure pressurizing fluid32 is introduced intofluid portion26. Pressure exerted by pressurizingfluid32 ondiaphragm36 causesflexible area38 ofdiaphragm36 to distend towardsgas portion24. The volume ofgas portion24 is thereby reduced and the gas contained therein is compressed.

In preferred embodiments of the present invention shown inFIGS. 3 and 4,moveable element28 is abladder44.Bladder44 is preferably constructed of a strong but very flexible material, and has a shape something similar to the shape of a child's balloon. At its maximum expansion,bladder44 extends to fill substantially all of the volume of hollow22. At its minimum expansion,bladder44 takes up little more volume than the volume of the materials of whichbladder44 is composed. In a preferred embodiment the volume ofbladder44 at minimum expansion is typically approximately 15% of the volume of hollow22.

In a preferred embodiment of the present invention shown inFIG. 3,gas portion24 is the interior volume ofbladder44 andfluid portion26 is the volume within hollow22 ofcontainer20 which is outside ofbladder44. During the first phase of operation, gas is introduced into the interior ofbladder44 throughgas input coupling46. During the second phase ofoperation pressurizing fluid32 is introduced into the volume within hollow22 ofcontainer20 which is outsidebladder44. Pressure exerted by pressurizingfluid32 onbladder44 causesbladder44 to contract, thereby exerting pressure on gas contained withinbladder44, and consequently compressing it.

In a preferred embodiment of the present invention shown inFIG. 4,gas portion24 is the volume within hollow22 ofcontainer20 which is outside ofbladder44. In this embodiment,fluid portion26 is the interior volume ofbladder44. During the first phase of operation gas is introduced into the portion of hollow22 which is exterior tobladder44, throughgas input coupling46, causingbladder44 to collapse. During the second phase ofoperation pressurizing fluid32 is introduced into the interior volume ofbladder44. Pressure exerted by pressurizingfluid32 on the interior ofbladder44 causesbladder44 to expand. Sincegas portion24 is the volume of hollow22 exterior tobladder44, expansion ofbladder44 causes a reduction of volume ofgas portion24, thereby compressing a gas therein.

It is to be noted that a configuration reversed with respect to those presented inFIG. 3 and inFIG. 4 is known in prior art, yet according to the teachings of the prior art the configuration is used to fulfill quite a different function. A device known in the art as an “accumulator” is used to pressurize a liquid, such as a hydraulic liquid, e.g., water or oil. An example is provided by the accumulator sold by Accumulators Inc. of 9042 Long Point Road, Huston Tex. 77055, part number A56100, or that sold by Ballas Engineering & Mechanization Ltd. of HaManor Street, Tel Aviv, Israel, and identified by part number SB800/1000. The function of this accumulator, and of all know usages of “accumulators” of similar design, according to the teachings of the prior art, is to pressurize a hydraulic liquid. For this purpose, a compressed gas is used. In other words, the usage of an accumulator according to the prior art is just the reverse of the usage presented herein. In a prior art accumulator, gas is introduced under pressure into a portion of the device, for the purpose of exerting a force on an extensible bladder in order to pressurize a liquid such as a hydraulic liquid like water or oil, which is then subsequently used in an application requiring a pressurized hydraulic liquid for operation. This is, of course, in sharp contrast to the configuration, purpose, and usages of the present invention, wherein a pressurizing fluid is used to compress a gas for use by a compressed gas utilizing application.

An advantage of an apparatus constructed in accordance with the teachings of the present invention is in the ability of the apparatus to supply gas at a constant and selected pressure. In each of the embodiments presented inFIGS. 1-4, pressure of a compressed gas held under pressure ingas portion24 will, during the second phase of operation, be substantially similar to pressure exerted by pressurizingfluid32 onmoveable element28. In a preferred mode of operation, pressurizingfluid32 is supplied byfluid pressurizer33 through pressurizingfluid input coupling48 at a constant pressure chosen to be an optimal pressure for a selected gas application.Bi-pump18 is thus enabled to supply compressed gas to compressedgas utilizing application42 at a substantially constant and optimized pressure. This is in sharp contrast to the configurations of prior art, in which compressed gas is typically supplied to compressed gas utilizing applications in the form of compressed gas containers, such as cylinders, of constant geometry. In such configurations, the pressure of compressed gas supplied to the application typically depends on the amount of gas remaining in the supplied container of gas. That pressure varies over time, pressure in the gas supply containers gradually falling as gas in the container is gradually used by the compressed gas utilizing application.

For some compressed gas utilizing applications, for example for the cryosurgery application discussed more fully hereinbelow, it is advantageous, for efficient operation of the application, to have a supply of compressed gas at a substantially constant pressure. Thus, the ability of a gas compression apparatus according to the present invention to supply compressed gas to a compressed gas utilizing application at a substantially constant and optimized pressure is an important advantage of the present invention over the configurations of the prior art.

An additional advantage of an apparatus according to the present invention lies in the ability of the apparatus to utilize, during the second phase of operation, substantially all of the gas supplied togas portion24 during the first phase of operation. Since the pressure of compressed gas supplied to compressedgas utilizing application42 throughgas output connector40 is not dependent on the amount of gas remaining in the apparatus, the second phase of operation can be continued until substantially all of the gas present ingas portion24 has been transferred throughgas output coupling40 to compressedgas utilizing application42. This is in sharp contrast to the typical situation of prior art, wherein the pressure of gas supplied in a gas cylinder or similar container gradually falls over time as gas is used. In such a system a point is reached at which the pressure of the gas supplied falls below the minimum pressure required by compressedgas utilizing application42. At that point the gas supply container must typically be returned for refilling by a supplier, despite the fact that a significant amount of valuable gas is still contained in the container. In a cryosurgery system, for example, the required gas pressure is typically so high that gas supply cylinders used by conventional cryosurgery systems are typically returned to a supplier for refilling with more than half the supplied gas still in the cylinder.

FIG. 5 presents a compressed gas utilization system according to the present invention.

At least onegas source100 supplies gas to aninput gas manifold102. Gas frominput gas manifold102 is compressed bygas compression apparatus104, then passes through an optionalcompressed gas manifold106 to a compressedgas delivery module108. In a preferred embodiment, compressedgas delivery module108 is a control module for controlling delivery of compressed gas to compressedgas utilizing application42, which utilizes the compressed gas.

Gas source

100 is a source of any gas. In a preferred embodiment of the present invention, a plurality ofgas sources100 are enabled to input gas to inputgas manifold102.

Gas source

100 may be a source of uncompressed gas, such as air.Gas source100 may also be a source of compressed gas at a low pressure, at a medium pressure, or at a high pressure. In a preferred embodiment,gas sources100 typically supply gas at a pressure lower than a pressure desired for a particular compressedgas utilizing application42. Examples ofcompressed gas sources100 include an industrial ‘always on’ compressed gas supply line, an external gas cylinder or similar gas container, a plurality of external gas cylinders or similar gas containers, an internal gas cylinder or similar gas container, and a plurality of internal gas cylinders or similar gas containers.

Gas fromgas sources100 is supplied throughinput gas manifold102 togas compression apparatus104.Gas compression apparatus104 is for raising the pressure of a gas from a first pressure, the gas pressure supplied bygas sources100, to a second pressure, a pressure appropriate for use by compressedgas utilizing application42. In a preferred embodiment,gas compression apparatus104 is a bi-pump18, described hereinabove.

Compressed gas fromgas compression apparatus104 passes through optionalcompressed gas manifold106 to compressedgas delivery module108, which controls delivery of compressed gas to compressedgas utilizing application42, where it is used.

An optionalgas recycling module118 is for recycling gas that is depressurized in consequence of having been utilized by compressedgas utilizing application42. Decompressed gas is recovered from compressedgas utilizing application42 or from compressedgas delivery module108 to agas recovery manifold120. Gas fromgas recovery manifold120 may optionally be repressurized or partially repressurized by an optionalrecycling gas pre-compressor122, and may further optionally be stored in a recoveredgas reservoir126. The recovered and repressurized gas is ultimately transported or guided to compressedgas utilizing application42, where it is re-used. In a preferred embodiment of the present invention presented inFIG. 5, the recovered gas, after optional pre-compression by recyclinggas pre-compressor122 and optional intermediate storage in recoveredgas reservoir126, is ultimately transported or guided to inputgas manifold102 for further repressurization bygas compression apparatus104, whence it is supplied for re-use by compressedgas utilizing application42.

A preferred embodiment of a compressed gas utilization system according to the present invention, wherein compressedgas utilizing application42 is acryosurgery application110, constitutes a departure from prior art, and presents several advantages over prior art configurations using compressed gas for cooling portions of a cryosurgery apparatus.

Referring again toFIG. 5, compressedgas utilizing application42 iscryosurgery application110, in which compressed gas is supplied to at least onecryoprobe112, preferably a plurality ofcryoprobes112.Cryoprobes112 utilize compressed gas in Joule-Thomson heat exchangers114 for cooling and optionally also forheating cryoprobes112. In a preferred embodiment, compressed cooling gasses are supplied tocryosurgery application110 to coolcryoprobes112, generally to affect cryoablation of tissues, and compressed heating gasses are supplied tocryosurgery application110 to heatcryoprobes112, generally to melt frozentissues touching cryoprobes112 so as to facilitate the disengagement ofcryoprobes112 from body tissues subsequent to cryoablation. In a preferred embodiment, gas decompressed by utilization incryoprobes112 is conducted, either directly or by way ofapplication42, togas recovery manifold120, for recompression and reuse as described hereinabove.

Prior art cryosurgery systems participate in the disadvantages of high pressure gas systems recited hereinabove. These disadvantages include the expense and inconvenience of acquiring high pressure gas for use in the systems, an inability to utilize substantially most of the high pressure gas supplied in high pressure gas cylinders or other gas containers, and the expense and wastefulness of systems which vent expensive gasses to the atmosphere after a single use.

A compressed gas utilization system according to the present invention, wherein compressedgas utilizing application42 iscryosurgery application110, overcomes these and other advantages of prior art systems.

Cryosurgery applications typically require high pressure gas for effective heating and cooling ofcryoprobes112. Argon, for example, is often used as a compressed gas for cryosurgery applications, and is optimally used at pressures in the range of 3000-4500 PSI. Industrial supply sources of compressed argon typically supply compressed argon at pressures of about 2500 PSI. Thus, a preferred embodiment of a compressed gas utilization system of the present invention enables to use argon gas compressed to medium pressure, which can conveniently be purchased from standard industrial sources, as agas source100, yet supplies high pressure argon to a compressedgas utilizing application42 such as acryosurgery application110. This ability constitutes a significant improvement over prior art.

In another preferred embodiment, also including acryosurgery application110 utilizingcryoprobes112, krypton gas is used as the compressed gas. Use of krypton gas instead of argon enables efficient cooling ofcryoprobes112 at lower pressures than those required for efficient cooling utilizing argon gas. Krypton gas enables efficient cooling at pressures in the neighborhood of 2,500 PSI, considerably lower than the pressures required for argon. Consequently, cryosurgery systems designed and constructed to be used with compressed krypton rather than compressed argon present various advantages, including relatively simplicity of construction and convenience of use.

In prior art cryosurgery systems compressed gas used for cooling a cryoprobe is typically subsequently vented to atmosphere rather than being recovered and recycled. Krypton gas, however, is expensive, and cannot be conveniently and economically used in such a prior art system. Thus a preferred embodiment of a compressed gas utilization system according to the present invention, wherein compressedgas utilizing application42 iscryosurgery application110, the embodiment further incorporating optionalgas recycling module118, enables efficient and economical use of compressed krypton in a cryosurgery application, thereby constituting a further significant improvement over prior art.

Thus, according to another aspect of the present invention there is provided a method for cryosurgery involving in situ compression of gas. The method according to this aspect of the invention is effected by using a first in situ gas compressor to compress a gas, thereby transforming the gas into a first compressed gas at a first gas pressure, transferring the first compressed gas at the first gas pressure from the first gas compressor to a cryoablation apparatus which utilizes the first compressed gas at the first gas pressure, and using the cryoablation apparatus to perform cryoablation.

According to yet another aspect of the present invention there is provided a method for cryosurgery, involving in situ compression of gas and further providing for re-compression and re-utilization of the gas. The method according to this aspect of the invention is effected by using a first in situ gas compressor to compress a gas, thereby transforming the gas into a first compressed gas at a first gas pressure, transferring the first compressed gas at the first gas pressure from the first gas compressor to a cryoablation apparatus which utilizes the first compressed gas at the first gas pressure, using the cryoablation apparatus to perform cryoablation, thereby creating a decompressed gas at a second gas pressure, transferring the depressurized gas at the second gas pressure either to the first gas compressor or to a second gas compressor for recompression and reuse, and recompressing and reusing the depressurized gas.

Still further advantages of a compressed gas utilization system according to the present invention may be particularly noted in preferred embodiments whereingas compression apparatus104 is a bi-pump18, bi-pump18 being a gas compression apparatus according to the present invention.

Use ofbi-pump18 enables to supply compressed gas at a continuous, even, selected pressure to compressedgas utilizing application42, irrespective of pressure levels ingas sources100. Use ofbi-pump18 further enables utilizing all or substantially most of a gas supplied in internal or external gas cylinders or other containers used asgas sources100. Use ofbi-pump18 presents the further advantage that bi-pump18 is not a rapidly reciprocating pump, therefore requires no lubrication and does not risk contamination of compressed gas by volatile lubricating materials.

Thus, according to another aspect of the present invention there is provided a method for supplying a compressed gas to a compressed gas utilizing application, utilizing a fixed-volume container having a hollow, and a moveable element subdividing the hollow into a first variable-volume portion and a second variable-volume portion. The method according to this aspect of the invention is effected by introducing a gas into the first variable-volume portion of the hollow during a first phase of operation, then introducing a hydraulic and/or pneumatic fluid under pressure into the second variable-volume portion of the hollow during a second phase of operation, thereby increasing a volume of the second variable-volume portion by moving the moveable element, thereby consequently decreasing a volume of the first variable-volume portion and compressing a gas contained therein, and transferring the compressed gas during the second phase of operation from the first variable-volume portion of the hollow to a compressed gas utilizing application.

Compressedgas delivery module108 may include various mechanisms such as valves, one-way valves, pressure re, dryers, filters and measuring devices for temperature and pressure, for managing the delivery of compressed gas to compressedgas utilizing application42, according to methods well known in the art.

In a preferred embodiment presented inFIG. 6, compressedgas delivery module108 further includes control elements for managing gas compression. Acontrol unit130 receives information fromapplication feedback element132. In the case a preferred embodiment in which compressedgas utilizing application42 is acryosurgery system110,application feedback element132 is plurality ofthermal sensors133, reporting on temperatures within various parts ofcryosurgery application110, such as withincryoprobes112. Other optional sensors included infeedback element132 are apressure sensor135 and amass flow sensor137.

Control unit

130 also receives information frominternal sensors136, which typically include pressure sensors and other, e.g., temperature sensors.

Control unit

130 also receives information and commands from anoptional command console134 for receiving commands from a user, and from optionalremote command module136, which is a data source such as an infrared remote control unit or other telecommunications device.

Control unit

130 optionally includes aprocessor140 andmemory142, used to coordinate and control various parts of the system. In a preferred embodiment,processor140 is operable to control gas compression and gas flow according to a set of programmed instructions stored inmemory142. Output fromcontrol unit130 goes to control elements of gasdelivery control system108, such as valves controlling flow of gas. In a preferredembodiment utilizing bi-pump18, output from control until130 also goes to control elements offluid pressurizer33 ofbi-pump18, for controlling the output pressure offluid pressurer33 and thereby controlling a compressed gas pressure of a compressed gas supplied bybi-pump18 through compressedgas manifold106 to compressedgas delivery module108.

Yet another embodiment of a compressed gas utilization system according to the present invention is presented byFIG. 7. In this preferred embodiment,gas source100 and bi-pump18 are combined into a single element, arechargeable bi-pump150. In a first phase of operation,rechargeable bi-pump150 is disconnected fromfluid pressurizer33 and fromcompressed gas manifold106, and is typically transported to a source of medium pressure gas, such as an industrial gas supply source, whererechargeable bi-pump150 is recharged with medium pressure gas in much the same way that classical gas cylinders are recharged with compressed gas.

In a second phase of operation, rechargedrechargeable bi-pump150 is re-connected tofluid pressurizer33 and togas output manifold106.Fluid pressurizer33 then applies pressure to pressurizingfluid32, as described hereinabove, further pressurizing gas ingas portion24 ofrechargeable bi-pump150, raising the pressure of a gas contained therein up to a pressure required by compressedgas utilizing application42. Compressed gas is then supplied throughgas output manifold106 and gasdelivery control module108 to compressedgas utilizing application42.

The embodiment ofFIG. 7 has several advantages over prior art, in particular the advantage that rechargeable bi-pump150 can be charged to medium pressure at an industrial gas supply source, yet can supply high pressure gas to compressedgas utilizing application42. The embodiment presents the further advantage that substantially all the gas supplied in a chargedrechargeable bi-pump150 can be delivered at high pressure to compressedgas utilizing application42, in distinct contrast to prior art systems in which a substantial portion of the gas supplied in a traditional gas supply cylinder or similar container cannot be so used. Further, the embodiment ofFIG. 7 presents the additional advantage of simplicity.

Yet, the embodiment ofFIG. 7 does present a disadvantage, in thatrechargeable bi-pump150 must contain sufficient gas to effect the entire operation of compressedgas utilizing application42, or else operation of compressedgas utilizing application42 must be interrupted while an emptiedrechargeable bi-pump150 is replaced by a rechargedrechargeable bi-pump150.

FIG. 8 presents an alternative construction of another preferred embodiment of the present invention, one which allows for continuous operation of compressedgas utilizing application42. In this embodimentgas input manifold102 supplies gas to a plurality ofbi-pumps18, represented inFIG. 8 by bi-pumps18aand18b.Gas input manifold102 supplies gas to bi-pumps18aand18bthrough one-way filters152 which allow gas to flow fromgas input manifold102 towards bi-pumps18aand18b, but do not allow gas to flow from bi-pumps18 towardsgas input manifold102.Control unit130 ofgas delivery module108 controls

fluid pressurizers

33aand33bin such a manner that when bi-pump18ais in its first phase ofoperation bi-pump18bis in its second phase of operation, and vice versa.

Thus, during a first period, bi-pump18ais in a first phase of operation, during which pressurizingfluid32ainfluid portion26ais not under pressure, and is indeed allowed to drain from bi-pump18aintofluid pressurizer33a. Gas pressure fromgas input manifold102, under pressure from at least onegas source100, exerts pressure on movingpartition18a, causinggas portion24ato expand and allowinggas portion24ato fill with gas fromgas input manifold102. Movement ofmoveable element28aalso causes orassists pressurizing fluid32ato drain fromfluid portion26a. Also during this first period, bi-pump18bis in its second phase of operation, during which pressurizingfluid32bis supplied byfluid pressurizer33bunder pressure, compressing gas ingas portion24b, which is then supplied throughgas output coupling40btooutput gas manifold106 and thence to compressedgas delivery module108 and thence to compressedgas utilizing application42.

During a second period, the roles of bi-pump18aand ofbi-pump18bare reversed. Bi-pump18aenters into its second phase of operation,fluid pressurizer33a

pressurizes pressurizing fluid

32a, thereby compressing a gas ingas portion24aof bi-pump18a. Compressed gas fromgas portion24ais supplied throughgas output coupling40atogas output manifold106 and then to compressedgas delivery module108 and thereafter to compressedgas utilizing application42. Also during this second period, bi-pump18b, which was partially or completely emptied of gas during the first period, is refilled: pressure fromfluid pressurizer33bis relaxed, pressurizingfluid32bis allowed to drain fromfluid portion26bofbi-pump18b, and the relaxed pressure influid portion24ballows gas pressure frominput gas manifold102 to movemoveable element28b, expandinggas portion24band fillinggas portion24bwith gas, while assisting in draining pressurizingfluid32bfromfluid portion26b.

Alternating first periods and second periods enables the system ofFIG. 8 to provide a continuous supply of pressurized gas to compressedgas utilizing application42. In the first period bi-pump18afills with gas while bi-pump18bsupplies compressed gas for compressedgas utilizing application42, then in thesecond period bi-pump18bfills with gas while bi-pump18asupplies compressed gas for compressedgas utilizing application42. The process then repeats, and can be repeated indefinitely, so long as agas source100 is available to supply gas togas input manifold102. An external or internal gas cylinder or other gas supply container can supply gas as many as several times to fill a bi-pump18, the gas being supplied each time at somewhat lower pressure as the supply cylinder gradually empties. Moreovermultiple gas sources100, multiple gas supply cylinders for example, may be connected togas input manifold102, hence it is possible to replace anempty gas source100 such as an empty gas supply cylinder with afull gas source100 such as a charged gas supply cylinder, without interrupting a flow of gas from at least onegas supply source100 togas input manifold102. Thus, the embodiment ofFIG. 8 enables continuous gas compression and continuous supply of compressed gas to compressedgas utilizing application42.

It is appreciated that certain features of the invention, which are, for clarity, described in the context of separate embodiments, may also be provided in combination in a single embodiment. Conversely, various features of the invention, which are, for brevity, described in the context of a single embodiment, may also be provided separately or in any suitable subcombination.

Although the invention has been described in conjunction with specific embodiments thereof, it is evident that many alternatives, modifications and variations will be apparent to those skilled in the art. Accordingly, it is intended to embrace all such alternatives, modifications and variations that fall within the spirit and broad scope of the appended claims.

Claims

1.-22. (canceled)

23. A method using in situ compression of gas during cryosurgery, comprising:

(a) using a first in situ gas compressor to compress a gas contained therein, thereby transforming said gas contained therein into a first compressed gas at a first gas pressure;

(b) transferring said first compressed gas at said first gas pressure from said first gas compressor to a cryoablation apparatus utilizing said first compressed gas at said first gas pressure;

(c) using said cryoablation apparatus to perform cryoablation, thereby creating a depressurized gas at a second gas pressure;

(d) transporting said depressurized gas to said first gas compressor for recompression and reuse; and

(e) recompressing and reusing said depressurized gas.

24. The method ofclaim 23, wherein said cryoablation apparatus comprises a Joule-Thomson heat exchanger for cooling a portion of said cryoablation apparatus.

25. The method ofclaim 23, wherein said transporting comprises using a mechanism which comprises a second gas compressor.

26. The method ofclaim 23, wherein said transporting comprises using a mechanism which comprises a gas reservoir.

27. The method ofclaim 23, wherein said first gas compressor comprises a volume which is coupled during a first phase of operation to a mechanism for transporting compressed gas from said volume to said cryoablation apparatus, and which is coupled during a second phase of operation to a mechanism for transporting gas depressurized by use in said cryoablation apparatus to said volume.

28. The method ofclaim 23, wherein said first gas compressor comprises a first refillable unit operable to be filled through a first input portal with a gas at one pressure while said first gas compressor supplies gas to said cryoablation apparatus at another pressure.

29. The method ofclaim 28, wherein said first gas compressor comprises a refillable volume which is detachable from said compressor and is portable.

30. The method ofclaim 28, wherein said first gas compressor comprises a second refillable unit.

31. The method ofclaim 30, further comprising refilling said first refillable unit with gas at one pressure while providing gas from said second refillable unit to said cryoablation apparatus at another pressure.