US20080102193A1 - Method For Coating Implantable Devices - Google Patents

Abstract

A method of forming a coating for an implantable medical device, such as a stent, is provided which includes applying a composition to the device in an environment having a selected pressure.

Description

• This application is a Continuation from U.S. patent application Ser. No. 10/792,551, filed Dec. 5, 2003, which is a Divisional Application from U.S. patent application Ser. No. 09/872,816, filed on 31 May 2001, now U.S. Pat. No. 6,743,462, the entire disclosure of which is incorporated by reference.
FIELD OF THE INVENTION
• This invention relates to an apparatus and method for coating implantable devices such as stents.
DESCRIPTION OF THE BACKGROUND
• Stents act as scaffoldings, functioning to physically hold open and, if desired, to expand the wall of the passageway. Typically stents are capable of being compressed, so that they can be inserted through small cavities via catheters, and then expanded to a larger diameter once they are at the desired location. Mechanical intervention via stents has reduced the rate of restenosis; restenosis, however, is still a significant clinical problem. Accordingly, stents have been modified to perform not only as a mechanical scaffolding, but also to provide biological therapy.
• Biological therapy can be achieved by medicating the stents. Medicated stents provide for the local administration of a therapeutic substance at the diseased site. In order to provide an efficacious concentration to the treated site, systemic administration of such medication often produces adverse or toxic side effects for the patient. Local delivery is a preferred method of treatment in that smaller total levels of medication are administered in comparison to systemic dosages, but are concentrated at a specific site. Local delivery thus produces fewer side effects and achieves more favorable results.
• A common method of medicating a stent is by depositing a polymeric coating, impregnated with the therapeutic substance, on the surface of the stent. A polymer dissolved in a solvent is applied to the stent. A therapeutic substance can be dissolved or dispersed in the composition. The solvent is allowed to evaporate to form the coating. The application of the composition can be performed by spraying the composition on the stent or immersing the stent in the composition.
• The solvents employed with the composition can be categorized as having a high vapor pressure or low vapor pressure. Non-volatile solvents evaporate very slowly from the composition causing coating defects such as inconsistency in the coating thickness and formation of “cob webs” or “pool webs” between the stent struts. A solution to this problem is to coat the stent at elevated temperatures to increase the evaporation rate of the solvent. However, not all drugs are stable at elevated temperatures. Volatile solvents have the tendency to evaporate very quickly from the composition resulting in a coating which has a powdered consistency and adheres poorly to the surface of the stent. Accordingly, what is needed is an apparatus and process for coating stents that does not suffer from the aforementioned drawbacks.
SUMMARY OF THE INVENTION
• In accordance with one aspect of the invention, a method of forming a coating for an implantable medical device, such as a stent, is provided. The method comprises applying a composition to the stent in an environment having a pressure other than ambient pressure. For compositions including a non-volatile solvent, the pressure can be less that 760 torr; for compositions including a volatile solvent, the pressure can be greater than 760 torr. The composition can include a polymer, such as an ethylene vinyl alcohol copolymer dissolved in a solvent, such as dimethylacetamide. Optionally, a therapeutic substance can be added to the composition, such as actinomycin D, paclitaxel, docetaxel, or rapamycin. In accordance to one embodiment, the composition can be applied by spraying the composition on the stent. During the act of applying, the stent can be rotated and/or moved in a linear direction along the longitudinal axis of the stent. The stent can be a radially expandable stent, such as a balloon expandable or self-expandable type.
• In accordance with another aspect of the invention, a method of forming a coating for a stent is provided, comprising positioning a stent in a chamber; applying a fluid to the stent; and adjusting the pressure of the chamber to increase or decrease the evaporation rate of the fluid.
• In accordance with another aspect of the invention, an apparatus for coating implantable medical devices such as stents is provided. The apparatus includes a chamber for housing a stent and a pressure controller for adjusting the pressure of the chamber during the coating process to a pressure below or above 760 torr. In one embodiment, an applicator can be provided for spraying a composition at the stent. A support assembly holds the stents in the chamber and can be connected to a motor for providing rotational and/or translational motion to the stent. A temperature controller can also be provided for adjusting the temperature of the chamber.
BRIEF DESCRIPTION OF THE FIGURE
• FIG. 1 illustrate a pressure chamber for forming a coating on a stent.
DETAILED DESCRIPTION OF THE EMBODIMENTSEmbodiments of the Pressure Chamber
• Referring toFIG. 1, there is illustrated apressure chamber10 defining aworkspace12 for depositing a composition on astent14 for forming a coating. A chamber opening (number omitted) can be provided for allowing a user to gain access intoworkspace12. Ahatch16 can be placed over the chamber opening for tightly sealing the opening during the deposition process. The size ofworkspace12 needs to be large enough so as to enclose asupport assembly18, such as a mandrel, for adequately supportingstent14 during the coating process.Workspace12 can be large enough so as to support any suitable number ofsupport assemblies18 andstents14.
• In one embodiment,support assembly18 can be connected to afirst motor assembly20A for rotation ofsupport assembly18 along the central, longitudinal axis x ofstent14. Asecond motor assembly20B can be additionally provided for translational movement ofsupport assembly18 in a linear direction, back and forth, along arailing22. The rotational and translational motion ofstent14 during the application of the composition can result in a more uniform deposition of the coating.
• Anapplicator24, such as a spray valve, penetrates through the wall ofpressure chamber10 and is positioned in the vicinity ofstent14. Commercial applicators are available from Spray Systems Co., EFD International Inc., and Badger Air-Brush Co., one specific model of which is the EFD 780S spray device with VALVEMATE 7040 control system. To avoid spray rate alterations due to the pressure difference,applicator24 can be placed entirely withinpressure chamber10. The nose ofapplicator24 can be positioned at any suitable distance away fromstent14, for example at about 1 cm to about 10 cm. An operator should be capable of adjusting the distance depending on the particular circumstances of the deposition process.Applicator24 is capable of applying the composition at a pressure of, for example, about 10 torr to about 1000 torr. In accordance with an alternative embodiment,support element18 can be in a vertical position andapplicator24 spraying in a horizontal direction.
• A pressure controller such as apump26 is in fluid communication withworkspace12 so as to create pressures below or above 760 torr (1 atm) inpressure chamber10. In one embodiment, acold trap28 can be provided for preventing the solvent or condensation from penetrating intopump26 should pump26 be used to create a vacuum inpressure chamber10. Afilter30, such as a mist filter, can also be provided to prevent droplets of coating composition from possibly reaching and damagingpump26. Other components ofpressure chamber10 can include athrottle valve32 for opening and closing the communication line to pump26, abaratron vacuum gauge34 for measuring the pressure inworkspace12 independent of the type and composition of the solvent vapor, and an absorbent36 for capturing the bulk of the composition over-spray. Gas, such as air, can be pumped or bled intopressure chamber10 for creating a convection flow insidepressure chamber10, to actively scavenge the solvent vapor fromworkspace12 and out throughpump26 so as to prevent solvent vapor build-up. Adiffuser38 can be used to diffuse or “spread out” the flow of gas so as to minimize disturbance of the spraying process. Ableed valve40 can be used for adjusting the flow rate of gas throughdiffuser38. In addition to rapidly removing the solvent vapor frompressure chamber10, bleedvalve40 can also be used to control the chamber pressure by working in concert withthrottle valve32.
• Pressure chamber10 can also be connected to a heating and/or coolingsource44 so as to control the temperature ofworkspace12. A cooler deposition environment, such as temperatures of less than 50° C. may be preferred depending on the chemical stability of the therapeutic substance and the type solvent used. In lieu of providing and external heating source, an internal component, such as heating and/or cooling coils, can be provided.
Method of Applying the Composition
• To form a coating on a surface ofstent14, the surface ofstent14 should be clean and free from contaminants that may be introduced during manufacturing. However, the surface ofstent14 requires no particular surface treatment to retain the applied coating.Stent14 is mounted onmandrel18 and the composition is sprayed viaapplicator24 at a pressure of, for example between 10 to 1000 torr. During the spraying of the composition, stent can be rotated at about 1 to about 120 rotations per minute.Stent14 can also be moved in a linear direction at speed of about 1 to about 20 cm/sec. The temperature ofchamber10 should be maintained at a temperature that does not adversely affect the therapeutic substance or the coating process—for example at about 20° C. to about 50° C.
• For a solvent having a low vapor pressure (e.g., below 30 torr at the temperature of application), or in other words non-volatile substances, the solvent evaporates very slowly from the composition, leading to irregularities in the coating thickness and “cob webs” or “pool webs” between the stent struts. Accordingly, compositions have been applied in short bursts, interrupted by the drying of the composition between each application step to minimize coating defects. Reducing the pressure ofchamber10 below ambient pressure during the coating process allows the solvent to evaporate more rapidly. Rapid evaporation of the solvent allows the composition to be applied continuously for depositing a coating of a suitable thickness or weight while minimizing coating defects such as “pool webs.” The pressure employed inpressure camber10 depends on the type of solvent employed. Table 1 is an exemplary list of non-volatile solvents and the suitable range of pressure which can be used in the process of the present invention:

  	TABLE 1
  		Exemplary Pressure Ranges
  	Solvent	torr @ 20° C.
  	Dimethylsulfoxide	0.8-<760
  	Dimethlacetamide	0.9-<760
  	Dimethylformamide	5.4-<760

• For a solvent having a high vapor pressure (e.g., above 30 torr at the temperature of application), or in other words volatile solvents, the solvent evaporates extremely rapidly from the composition, leading to difficulties in the application of the composition to the stent. Application of such compositions often lead to coatings having powdered consistency and poor adhesion of the coating to the surface of the stent. Increasing the pressure inpressure chamber10 above ambient pressure causes the solvent to evaporate more slowly leading to a coating with a smoother surface, more uniform composition, and better adhesion. Table 2 is an exemplary list of volatile solvents and the suitable range of pressure which can be used in the process of the present invention:

  	TABLE 2
  		Exemplary Pressure Ranges
  	Solvent	torr @ 20° C.
  	Toluene	>760-2000
  	n-propanol	>760-3400
  	Acetone	>760-9000

The Composition
• The embodiments of the composition can be prepared by conventional methods wherein all components are combined, then blended. More particularly, in accordance to one embodiment, a predetermined amount of a polymer or combination of polymers can be added to a predetermined amount of a solvent or a combination of solvents. If necessary, heating, stirring and/or mixing can be employed to effect dissolution of the polymer(s) into the solvent(s)—for example in an 80° C. water bath for two hours. A therapeutic substance can be also added to the composition. The therapeutic substance should be in true solution or saturated in the blended composition. If the therapeutic substance is not completely soluble in the composition, operations including mixing, stirring, and/or agitation can be employed to effect homogeneity of the residues. The therapeutic substance may be added so that dispersion is in fine particles. The mixing of the therapeutic substance can be conducted at ambient pressure and at room temperature.
• The polymer or combination of polymers chosen must be biocompatible and minimize irritation to the vessel wall when the device is implanted. The polymer may be either a biostable or a bioabsorbable polymer. Bioabsorbable polymers that could be used include poly(hydroxyvalerate), poly(L-lactic acid), polycaprolactone, poly(lactide-co-glycolide), poly(hydroxybutyrate), poly(hydroxybutyrate-co-valerate), polydioxanone, polyorthoester, polyanhydride, poly(glycolic acid), poly(D,L-lactic acid), poly(glycolic acid-co-trimethylene carbonate), polyphosphoester, polyphosphoester urethane, poly(amino acids), cyanoacrylates, poly(trimethylene carbonate), poly(iminocarbonate), copoly(ether-esters) (e.g. PEO/PLA), polyalkylene oxalates, polyphosphazenes and biomolecules such as fibrin, fibrinogen, cellulose, starch, collagen and hyaluronic acid. Also, biostable polymers with a relatively low chronic tissue response such as polyurethanes, silicones, and polyesters could be used. Other polymers include polyolefins, polyisobutylene and ethylene-alphaolefin copolymers; acrylic polymers and copolymers; vinyl halide polymers and copolymers, such as polyvinyl chloride; polyvinyl ethers, such as polyvinyl methyl ether; polyvinylidene halides, such as polyvinylidene fluoride and polyvinylidene chloride; polyacrylonitrile; polyvinyl ketones; polyvinyl aromatics, such as polystyrene; polyvinyl esters, such as polyvinyl acetate; copolymers of vinyl monomers with each other and olefins, such as ethylene-methyl methacrylate copolymers, acrylonitrile-styrene copolymers, ABS resins, and ethylene-vinyl acetate copolymers; polyamides, such as Nylon 66 and polycaprolactam; alkyd resins; polycarbonates; polyoxymethylenes; polyimides; polyethers; epoxy resins; polyurethanes; rayon; rayon-triacetate; cellulose, cellulose acetate; cellulose butyrate; cellulose acetate butyrate; cellophane; cellulose nitrate; cellulose propionate; cellulose ethers; and carboxymethyl cellulose. Ethylene vinyl alcohol is functionally a very suitable choice of polymer. The copolymer possesses good adhesive qualities to the surface of a stent, particularly stainless steel surfaces, and has illustrated the ability to expand with a stent without any significant detachment of the copolymer from the surface of the stent. The copolymer, moreover, allows for good control capabilities over the release rate of the therapeutic substance.
• Representative examples of solvents include chloroform, acetone, water (buffered saline), dimethylsulfoxide (DMSO), propylene glycol methyl ether (PM,) iso-propylalcohol (IPA), n-propylalcohol, methanol, ethanol, tetrahydrofuran (THF), dimethylformamide (DMF), dimethyl acetamide (DMAC), benzene, toluene, xylene, hexane, cyclohexane, heptane, octane, nonane, decane, decalin, ethyl acetate, butyl acetate, isobutyl acetate, isopropyl acetate, butanol, diacetone alcohol, benzyl alcohol, acetone, 2-butanone, cyclohexanone, dioxane, methylene chloride, carbon tetrachloride, tetrachloro ethylene, tetrachloro ethane, chlorobenzene, 1,1,1-trichloroethane, formamide, and combination there of. The solvent should be capable of placing the selected polymer into dissolution at the selected concentration and should not adversely react with the therapeutic substance.
• The therapeutic substance can include any agent capable of exerting a therapeutic or prophylactic effect in the practice of the present invention such as inhibition of migration and/or proliferation of smooth muscle cells. The agent can also be for enhancing wound healing in a vascular site and improving the structural and elastic properties of the vascular site. Examples of agents include antiproliferative substances as well as antineoplastic, antiinflammatory, antiplatelet, anticoagulant, antifibrin, antithrombin, antimitotic, antibiotic, antioxidant, and combinations thereof. One suitable example of an antiproliferative substance includes actinomycin D—synonyms of which include dactinomycin, actinomycin IV, actinomycin I₁, actinomycin X₁, and actinomycin C₁. Examples of suitable antineoplastics include paclitaxel and docetaxel. Examples of suitable antiplatelets, anticoagulants, antifibrins, and antithrombins include sodium heparin, low molecular weight heparin, hirudin, argatroban, forskolin, vapiprost, prostacyclin and prostacyclin analogs, dextran, D-phe-pro-arg-chloromethylketone (synthetic antithrombin), dipyridamole, glycoprotein IIb/IIIa platelet membrane receptor antagonist, recombinant hirudin, thrombin inhibitor (available from Biogen), and 7E-3B® (an antiplatelet drug from Centocore). Examples of suitable antimitotic agents include methotrexate, azathioprine, vincristine, vinblastine, fluorouracil, adriamycin, and mutamycin. Examples of suitable cytostatic or antiproliferative agents include angiopeptin (a somatostatin analog from Ibsen), angiotensin converting enzyme inhibitors such as CAPTOPRIL (available from Squibb), CILAZAPRIL (available from Hoffman-LaRoche), or LISINOPRIL (available from Merck); calcium channel blockers (such as Nifedipine), colchicine, fibroblast growth factor (FGF) antagonists, fish oil (omega 3-fatty acid), histamine antagonist, LOVASTATIN (an inhibitor of HMG-CoA reductase, a cholesterol lowering drug from Merck), monoclonal antibodies (such as PDGF receptors), nitroprusside, phosphodiesterase inhibitors, prostaglandin inhibitor (available form Glazo), Seramin (a PDGF antagonist), serotonin blockers, steroids, thioprotease inhibitors, triazolopyrimidine (a PDGF antagonist), and nitric oxide. Other therapeutic substances or agents which may be appropriate include alpha-interferon, genetically engineered epithelial cells, rapamycin, and dexamethasone.
• The dosage or concentration of the active agent required to produce a favorable therapeutic effect should be less than the level at which the active agent produces toxic effects and greater than the level at which non-therapeutic results are obtained. The dosage or concentration of the active agent required to inhibit the desired cellular activity of the vascular region can depend upon factors such as the particular circumstances of the patient; the nature of the trauma; the nature of the therapy desired; the time over which the ingredient administered resides at the vascular site; and if other therapeutic agents are employed, the nature and type of the substance or combination of substances. Therapeutic effective dosages can be determined empirically, for example by infusing vessels from suitable animal model systems and using immunohistochemical, fluorescent or electron microscopy methods to detect the agent and its effects, or by conducting suitable in vitro studies. Standard pharmacological test procedures to determine dosages are understood by one of ordinary skill in the art.
• Stent is broadly intended to include self-expandable stents, balloon-expandable stents, and stent-grafts. One of ordinary skill in the art, however, understands that other medical devices on which a polymer can be coated can be used with the practice of the present invention, such as grafts (e.g., aortic grafts), endocardial leads, valves, and alike. The underlying structure of the device can be virtually any design. Stents are typically defined by tubular body having a plurality of bands or cylindrical elements interconnected by connecting elements. The device can be made of a metallic material or an alloy such as, but not limited to, cobalt chromium alloy (ELGILOY), stainless steel (316L), “MP35N,” “MP20N,” ELASTINITE (Nitinol), tantalum, nickel-titanium alloy, platinum-iridium alloy, gold, magnesium, or combinations thereof. “MP35N” and “MP20N” are trade names for alloys of cobalt, nickel, chromium and molybdenum available from standard Press Steel Co., Jenkintown, Pa. “MP35N” consists of 35% cobalt, 35% nickel, 20% chromium, and 10% molybdenum. “MP20N” consists of 50% cobalt, 20% nickel, 20% chromium, and 10% molybdenum. Devices made from bioabsorbable or biostable polymers could also be used with the blended composition.
• While particular embodiments of the present invention have been shown and described, it will be obvious to those skilled in the art that changes and modifications can be made without departing from the embodiments this invention in its broader aspects and, therefore, the appended claims are to encompass within their scope all such changes and modifications as fall within the true spirit and scope of the embodiments this invention.

Claims (10)

1. A method of forming a coating for an implantable medical device, comprising

inserting the device into a chamber;

adjusting the pressure of the chamber to a pressure greater than ambient pressure;

followed by applying a composition comprising a solvent to the implantable device while the device is disposed in an environment having the pressure at greater than ambient pressure, wherein the pressure and temperature in the chamber are always less than the critical pressure and temperature of the solvent during the adjustment of the pressure and during the coating of the device.

2. The method ofclaim 1 wherein the composition comprises a polymer dissolved in the solvent and optionally a therapeutic substance added thereto.

3. The method ofclaim 2 wherein the therapeutic substance is

an antiproliferative antineoplastic, antiinflammatory, antiplatelet, anticoagulant, antifibrin, antithrombin, antimitotic, antioxidant, or a combination of these; or

an antibiotic combined with an antiproliferative antineoplastic, antiinflammatory, antiplatelet, anticoagulant, antifibrin, antithrombin, antimitotic, antioxidant, or a combination of these.

4. The method ofclaim 2 wherein the solvent comprises a compound selected from chloroform, acetone, water, buffered saline, dimethylsulfoxide, propylene glycol methyl ether, isopropyl alcohol, n-propyl alcohol, methanol, ethanol, tetrahydrofuran, dimethylformamide, dimethyl acetamide, benzene, toluene, xylene, hexane, cyclohexane, heptane, octane, nonane, decane, decalin, ethyl acetate, butyl acetate, isobutyl acetate, isopropyl acetate, butanol, diacetone alcohol, benzyl alcohol, acetone, 2-butanone, cyclohexanone, dioxane, methylene chloride, carbon tetrachloride, tetrachloroethylene, tetrachloroethane, chlorobenzene, 1,1,1-trichloroethane, formamide, and their combinations.

5. The method ofclaim 1 wherein the act of applying comprises spraying the composition on the implantable device.

6. The method ofclaim 1 wherein the implantable device is a stent and the act of applying comprises spraying the composition while rotating the stent about the longitudinal axis of the stent.

7. The method ofclaim 1 wherein the implantable device is a stent and the act of applying comprises spraying the composition while moving the stent in a linear direction along the longitudinal axis of the stent.

8. The method ofclaim 1 wherein the composition includes a therapeutic substance and wherein the temperature of the chamber is adjusted to a temperature that does not adversely affect the therapeutic substance.

9. The method ofclaim 8 wherein the composition comprises a polymer dissolved in the solvent.

10. A method of forming a coating for an implantable medical device, comprising

i) inserting the device into a chamber;

ii) adjusting the pressure of the chamber to a pressure greater than ambient pressure;

iii) followed by applying a composition comprising a solvent to the implantable device while the device is disposed in an environment having the pressure at greater than ambient pressure, wherein the pressure and temperature in the chamber are in a range of values such that the solvent evaporates during the formation of the coating on the device.

Images