US20080058794A1 - Electrophysiology System for Mapping and Ablating Arrhythmias - Google Patents

Abstract

An electrophysiology system for mapping and/or ablating tissue includes a catheter having a plurality of electrically active sites. The system includes a controller providing a user interface through which the plurality of sites may be controlled. The sites may be accessed individually or in groups. In addition, the order and timing of the accessing of specific electrically active sites may be controlled in a manual or automated fashion.

Description

RELATED APPLICATIONS
• This application claims priority under 35 U.S.C. § 119(e) to U.S. Provisional Application Ser. No. 60/571,781, entitled “MAPPING AND ABLATION METHOD AND APPARATUS FOR THE TREATMENT OF IDIOPATHIC VENTRICULAR TACHYCARDIA ORIGINATING FROM RVOT OR LVOT,” filed on May 17, 2004, which is herein incorporated by reference in its entirety, and U.S. Provisional Application Ser. No. 60/571,843, entitled “MAPPING AND ABLATION METHOD AND APPARATUS FOR THE TREATMENT OF IDIOPATHIC VENTRICULAR TACHYCARDIA,” filed on May 17, 2004, which is herein incorporated by reference in its entirety. This application claims priority under 35 U.S.C. § 119(e) to U.S. Provisional Application Ser. No. 60/571,821, entitled “METHOD AND APPARATUS FOR MAPPING AND/OR ABLATION OF CARDIAC TISSUE,” filed on May 17, 2004, which is herein incorporated by reference in its entirety.
BACKGROUND OF INVENTION
• 1. Field of Invention
• The invention relates generally to medical devices for performing mapping and ablation procedures. More particularly, the invention relates to a system for mapping and/or ablating cardiac walls.
• 2. Discussion of Related Art
• The human heart is a very complex organ, which relies on both muscle contraction and electrical impulses to function properly. The electrical impulses travel through the heart walls, first through the atria and then the ventricles, causing the corresponding muscle tissue in the atria and ventricles to contract. Thus, the atria contract first, followed by the ventricles. This order is essential for proper functioning of the heart.
• Over time, the electrical impulses traveling through the heart can begin to travel in improper directions, thereby causing the heart chambers to contract at improper times. Such a condition is generally termed a cardiac arrhythmia, and can take many different forms. When the chambers contract at improper times, the amount of blood pumped by the heart decreases, which can result in premature death of the person.
• Techniques have been developed which are used to locate cardiac regions responsible for the cardiac arrhythmia, and also to disable the short-circuit function of these areas. According to these techniques, electrical energy is applied to a portion of the heart tissue to ablate that tissue and produce scars which interrupt the reentrant conduction pathways or terminate the focal initiation. The regions to be ablated are usually first determined by endocardial mapping techniques. Mapping may be active or passive. Active mapping, sometimes called “pace mapping,” typically involves percutaneously introducing a catheter having one or more electrodes into the patient, passing the catheter through a blood vessel (e.g. the femoral vein or artery) and into an endocardial site (e.g., the atrium or ventricle of the heart), and deliberately inducing an arrhythmia so that a continuous, simultaneous recording can be made with a multichannel recorder at each of several different endocardial positions. Passive mapping techniques typically involve sensing electrical signals from the electrodes on the catheter.
• When an arrythormogenic focus or inappropriate circuit is located, as indicated in the electrocardiogram recording, it is marked by various imaging or localization means so that cardiac arrhythmias emanating from that region can be blocked by ablating tissue. An ablation catheter with one or more electrodes can then transmit electrical energy to the tissue adjacent the electrode to create a lesion in the tissue. One or more suitably positioned lesions will typically create a region of necrotic tissue which serves to disable the propagation of the errant impulse caused by the arrythromogenic focus. Ablation is carried out by applying energy to the catheter electrodes. The ablation energy can be, for example, RF, DC, ultrasound, microwave, or laser radiation.
• Atrial fibrillation together with atrial flutter are the most common sustained arrhythmias found in clinical practice. Current understanding is that atrial fibrillation is frequently initiated by a focal trigger from the orifice of or within one of the pulmonary veins. Though mapping and ablation of these triggers appears to be curative in patients with paroxysmal atrial fibrillation, there are a number of limitations to ablating focal triggers via mapping and ablating the earliest site of activation with a “point” radiofrequency lesion. One way to circumvent these limitations is to determine precisely the point of earliest activation. Once the point of earliest activation is identified, a lesion can be generated to electrically isolate the trigger with a lesion; firing from within those veins would then be eliminated or unable to reach the body of the atrium, and thus could not trigger atrial fibrillation.
• Another method to treat focal arrhythmias is to create a continuous, annular lesion around the ostia (i.e., the openings) of either the veins or the arteries leading to or from the atria, thus “corralling” the signals emanating from any points distal to the annular lesion. Conventional techniques include applying multiple point sources around the ostia in an effort to create such a continuous lesion. Such a technique is relatively involved, and requires significant skill and attention from the clinician performing the procedures.
• Another source of arrhythmias may be from reentrant circuits in the myocardium itself. Such circuits may not necessarily be associated with vessel ostia, but may be interrupted by means of ablating tissue either within the circuit or circumscribing the region of the circuit. It should be noted that a complete “fence” around a circuit or tissue region is not always required in order to block the propagation of the arrhythmia; in many cases simply increasing the propagation path length for a signal may be sufficient. Conventional means for establishing such lesion “fences” include a multiplicity of point-by-point lesions, dragging a single electrode across tissue while delivering energy, or creating an enormous lesion intended to inactivate a substantive volume of myocardial tissue.
• U.S. Pat. No. 6,315,778 B1, entitled “Apparatus For Creating A Continuous Annular Lesion,” which is herein incorporated by reference, discloses a medical device which is capable of ablating a ring of tissue around the ostia of either veins or arteries leading to or from the atria. The medical device includes a protrusion that inserts into an ostium, thereby allowing electrodes to contact tissue near the ostium.
• In some instances, it is desirable to perform mapping and/or ablation procedures on a cardiac wall (or other tissue) that is not located near an ostium. In such a scenario, the lack of a protrusion may help to allow electrodes of a device contact the cardiac wall or other tissue. In other cases, mapping and/or ablation may be desired at several locations around an ostium and it would be helpful to be able to position electrodes without concern for a protrusion that may hinder contact between electrodes and the cardiac wall.
• Another type of arrhythmia is Ventricular tachycardia. Ventricular tachycardia (VT) usually arises in diseased myocardium. However, VT can occur in the absence of structural heart disease, or at least in hearts in which current diagnostic techniques fail to identify any anatomic or functional abnormalities. These arrhythmias have been termed “idiopathic VTs”. The mechanisms underlying idiopathic VT are varied and include reentry and triggered activity due to delayed after depolarizations.
• Idiopathic VTs that arise from the right to left ventricular outflow tract (RVOT VT and LVOT VT) have been reported. Thus RVOT VT and LVOT VT patients could be treated with RF ablation. However, the success rate of ablation therapy for treatment of VT is affected by many factors, such as the inability to induce tachycardia to permit mapping, and the presence of deep, often septal sites of origin that are resistant to RF ablation with conventional ablation catheters, usually a 4-mm ablation catheter. Treating VT in the area of the outflow track with ablation therapy has been difficult.
SUMMARY OF INVENTION
• Embodiments of the present invention encompass apparatus and methods for mapping electrical activity within the heart. Embodiments of the present invention also encompass methods and apparatus for creating lesions in the heart tissue (ablating) to create a region of necrotic tissue which serves to disable the propagation of errant electrical impulses caused by an arrhythmia. The apparatus and methods described herein also may be used for mapping and ablating of tissue other than heart tissue.
• In one aspect, the invention relates to a computer-readable medium comprising computer-executable instructions for controlling an electrophysiology system of the type having a catheter with a plurality of electrically active sites. The computer-executable instructions performing acts of providing at least one display area through which a user may specify a set of the electrically active sites to be used in sensing signals from the heart; providing at least one display area through which a user may specify a set of the electrically active sites to be used in sending stimulation signals to the heart; and providing at least one display area through which a user may specify a set of the electrically active sites to be used in sending an ablation signal to the heart.
• In another aspect, the invention relates to a computer-readable medium comprising computer-executable instructions for controlling an electrophysiology system of the type having a catheter with a plurality of electrically active sites. The computer-executable instructions for performing acts of, for each of a plurality of sets of electrically active sites, receiving from a user a specification of the electrically active sites in the set; and receiving from the user a specification of a specified order of the plurality of sets; and for each of the sets, successively in the specified order, controlling the electrophysiology system to access the electrically active sites of the set.
• In a further aspect, the invention relates to a method of providing and selecting from a menu on a display in an electrophysiology system having a catheter with a plurality of electrically active sites and a computer having a graphical user interface, the method involves: displaying on the display a graphical representation of each of the plurality of electrically active sites on the catheter; receiving at least one selection signal indicative of the user interface selection device pointing at a graphical representation of a selected one of the plurality of electrically active sites; and controlling the electrophysiology system to selectively access at least one of the electrically active sites based on the at least one selection signal.
BRIEF DESCRIPTION OF DRAWINGS
• The accompanying drawings are not intended to be drawn to scale. In the drawings, like components that are illustrated in various figures are represented by a like numeral. For purposes of clarity, not every component may be labeled in every drawing. In the drawings:
• FIG. 1 illustrates an overview of an electrophysiology system in accordance with one embodiment of the present invention;
• FIG. 2 illustrates a braided conductive member in an undeployed state that may be used in one embodiment of the invention;
• FIG. 3 illustrates a braided conductive member in a partially expanded state that may be used in one embodiment of the invention;
• FIG. 4 illustrates a braided conductive member in an inverted state that may be used in one embodiment of the invention;
• FIG. 5 illustrates a braided conductive member in an inverted state where a distal end of the braided conductive member does not protrude distally from the inverted braided conductive member that may be used in one embodiment of the invention;
• FIG. 6 illustrates a braided conductive member including support elements that may be used in one embodiment of the invention;
• FIG. 7 illustrates a braided conductive member that may be used in another embodiment of the invention;
• FIG. 8 illustrates an alternate embodiment of the braided conductive member that may be used in another embodiment of the invention;
• FIG. 9 illustrates the use of irrigation that may be used in one embodiment of the invention;
• FIG. 10 illustrates the use of irrigation that may be used in another embodiment of the invention;
• FIG. 10A is an enlarged cross-sectional view of a filament used in the braided conductive member illustrated inFIG. 10;
• FIG. 11 illustrates one embodiment of a method of using a catheter and the braided conductive member;
• FIG. 12 is a sketch showing the electrophysiology system ofFIG. 1 in greater detail;
• FIGS. 13A and 13B are sketches of graphical user interfaces in embodiments of the electrophysiology system ofFIG. 12; and
• FIG. 14 is a flow chart of a method of operation of the electrophysiology system ofFIG. 12.
DETAILED DESCRIPTION
• This invention is not limited in its application to the details of construction and the arrangement of components and acts set forth in the following description or illustrated in the drawings. The invention is capable of other embodiments and of being practiced or of being carried out in various ways. Also, the phraseology and terminology used herein is for the purpose of description and should not be regarded as limiting. The use of “including,” “comprising,” or “having,” “containing”, “involving”, and variations thereof herein, is meant to encompass the items listed thereafter and equivalents thereof as well as additional items.
• System Overview
• Reference is now made toFIG. 1, which illustrates an overview of an electrophysiology system, such as may be used for mapping and/or ablation to detect and treat cardiac arrhythmia. The system includes acatheter10 having ashaft portion12, acontrol handle14, aconnector portion16, and a braidedconductive member28. Acontroller8 is connected toconnector portion16 viacable6.Ablation energy generator4 may be connected tocontroller8 viacable3. Arecording device2 may be connected tocontroller8 viacable1. When used in an ablation application,controller8 is used to control ablation energy provided tocatheter10 byablation energy generator4. When used in a mapping application,controller8 is used to process signals coming fromcatheter10 and to provide these signals torecording device2. Although illustrated as separate devices,recording device2,ablation energy generator4, andcontroller8 could be incorporated into a single device or two devices.
• In this description, various aspects and features of exemplary embodiments of the present invention will be described. These aspects and features are discussed separately for clarity. One skilled in the art will appreciate that the features may be selectively combined in a device depending upon the particular application. Furthermore, any of the various features may be incorporated in a system and associated method of use for either mapping and/or ablation procedures.
• Catheter Overview
• Reference is now made toFIGS. 2-5, which illustrate a catheter that may be used in the electrophysiology system ofFIG. 1. Embodiments of the present invention generally include a catheter and methods of its use for mapping and ablation in electrophysiology procedures.
• FIG. 2 illustrates braidedconductive member28 in an unexpanded state. In this embodiment, the unexpanded state of the braided conductive member is an undeployed configuration. Braidedconductive member28 is, in one embodiment of the invention, a plurality of interlaced, electricallyconductive filaments34 which are attached at adistal end18 with acap24 and also at aproximal end19 with an anchoringelement32. Of course any suitable element or method may be used to attach oranchor filaments34.
• FIG. 3 illustrates braidedconductive member28 in a partially expanded state. Each ofFIGS. 2 and 3 show a state in which braidedconductive member28 is completely everted.
• FIG. 4 illustrates braidedconductive member28 in a first deployed configuration option which may be used to locate braidedconductive member28 at an ostium. InFIG. 4,distal end18 of braidedconductive member28 is partially inverted. The terms “partially invert” and “partially inverted”, for purposes herein, refer to a configuration in which portions of filaments are retracted within the braided conductive member such that they are at least partially surrounded by other portions of filaments. A tip, or other portions of the braided conductive member may protrude distally from any distally-facing surface of the braided conductive member when the braided conductive member is partially inverted.
• FIG. 5 illustrates braidedconductive member28 in a second deployed configuration option which may be used to effect contact between an annular surface of braidedconductive member28 and a cardiac wall (see, for example,FIG. 11) other cardiac tissue, or other target tissue. InFIG. 5, the distal tip of braidedconductive member28 is inverted. The terms “invert” or “inverted”, for purposes herein, refer to a configuration in which the distal tip or distal end of the braided conductive member is retracted such that the distal tip does not protrude distally from a distally-facing surface of the braided conductive member. For purposes herein, the terms “evert” or “everted” refer to a configuration in which the distal tip or distal end of the braided conductive member protrudes distally from any distally-facing annular surface that is present. An everted configuration does not, however, require that a distally-facing annular surface be present. In some embodiments, such as the embodiment illustrated inFIG. 2, the braided conductive member is fully elongated in an everted configuration. The term “completely everted”, when referring to a distal region of a braided conductive member, refers to a configuration in which no portion of the distal region of the braided conductive member is inverted within itself.
• A braided conductive member adjustment element, such as acable22, is attached todistal end18 of braidedconductive member28.Cable22 may extend through a lumen (not shown) inshaft portion12 and through the interior of braidedconductive member28.Cable22 may be attached todistal end18 of braidedconductive member28 usingcap24, an anchor band, or any suitable attachment or anchoring element or method known in the art. At the control handle end,cable22 may be attached to a control element, such as a slide actuator for example, that allows a user to retract and advancecable22. It should be noted thatcable22 is a separate element fromcables1,3 and6. Of course, braided conductive member adjustment element need not be a cable as any suitable element for adjusting the braided conductive member may be used. For example, a sheath may be used to push the braided conductive member over the distal tip of the braided conductive member to invert braidedconductive member28.
• In operation, movingcable22 in the proximal direction causes braidedconductive member28 to compress longitudinally and/or to expand radially, as shown inFIG. 3. Further proximal movement ofcable22 causes a portion of braidedconductive member28 to invert as shown inFIG. 4. Even further proximal movement ofcable22 may retractdistal end18 such thatdistal end18 is encircled by a portion of braidedconductive member28. In some embodiments,distal end18 may be surrounded or partially surrounded by a portion of braidedconductive member28 that does not form a circle.
• In some embodiments, a certain amount of movement ofcable22 in the proximal direction may occur without user actuation due to the bias of the braidedconductive member28. For example, braidedconductive member28 may be longitudinally extended beyond a relaxed state by radially compressing braidedconductive member28 with a sheath33 (seeFIG. 2). Upon retraction ofsheath33, braidedconductive member28 may radially expand a certain amount due to its filament winding structure, or due to elastic or spring elements attached to the filaments. In further embodiments,cable22 may be used to urge braidedconductive member28 back into a longitudinally extended state by pushing oncap24 or other distal attachment portion.
• By retractingdistal end18 of braidedconductive member28 at least a certain distance in the proximal direction, a braided conductive memberannular surface30 may be formed in a plane that is substantially perpendicular to adistal end26 ofshaft portion12, as illustrated inFIG. 4. Retractingdistal end18 further removes the projection ofdistal end18 beyondannular surface30, as illustrated inFIG. 5, which may allowannular surface30 to be placed in contact with a cardiac wall or other cardiac tissue. If braidedconductive member28 is only partially inverted anddistal end18 projects beyondannular surface30 in the distal direction, it may hinder efforts to contact cardiac tissue with the annular surface. In some embodiments, however, it may be desirable to maintain a portion ofdistal end18 projecting from braidedconductive member28 so that braidedconductive member28 may be positioned relative to an ostium by insertingdistal end18 into the ostium. In some embodiments, the annular surface may be arranged such that it is contactable to a substantially flat area of tissue that has no ostia, even though an element may protrude distally from the annular surface. For example, a highly flexible element, such as a touch sensor, may protrude distally from the inverted braided conductive member and the annular surface would still be arranged such that it is contactable to a substantially flat area of tissue that has no ostia. The touch sensor may be a bend sensor that is positioned on the distal tip of the braided conductive member and protrudes slightly from the distally-facing surface when the braided conductive member is put into a deployed configuration. The bend sensor bends upon encountering a tissue wall and signals the controller that it has bent. The flexibility of the bend sensor allows the braided conductive member to contact the wall.
• For purposes herein, a “surface” of braidedconductive member28 refers to a plurality of interlaced conductive elements, such as filaments or wires, even though the interlaced elements may not fully occupy the space considered to be the surface. In some embodiments, wires or other conductive elements may be attached to or embedded in a flexible support material such that a solid surface is present.
• The annular surface formed by inverting the braidedconductive member28 may have electrodes spaced around the entire annular surface. In other embodiments, electrodes may be positioned only on a portion or portions of the ring-shaped surface.
• As illustrated inFIGS. 2-5, asheath33 may be provided.Sheath33 serves to protectshaft portion12 and braidedconductive member28 during manipulation through the patient's vasculature. In addition,sheath33 may shield braidedconductive member28 from the patient's tissue in the event ablation energy is prematurely delivered to the braidedconductive member28.
• Sheath33 may be advanced and retracted overshaft portion12 in any suitable manner. Control handle14 may be used to effect the advancement or retraction ofsheath33. U.S. Pat. Nos. 5,383,852, 5,462,527, and 5,611,777, which are herein incorporated by reference in their entireties, illustrate examples of control handles that can controlsheath33. As described in these patents, control handle14 may include a slide actuator which is axially displaceable relative to the handle. The slide actuator may be connected tosheath33 to retractsheath33 to expose braidedconductive member28 once the distal end of the catheter has been positioned within the heart or other target location.
• Braidedconductive member28 may be shape or biased such that whensheath33 is retracted, braidedconductive member28 expands slightly in the radial direction. In other embodiments, braidedconductive member28 may maintain its longitudinally extended shape untilcable22 or other adjustment element is pulled in the proximal direction to longitudinally compress braidedconductive member28. In still other embodiments, braidedconductive member28 may maintain a radial size similar to its relaxed state radial size whendistal tip18 is moved proximally, or even when braidedconductive member28 is inverted.
• Braidedconductive member28 is, in one embodiment of the invention, a plurality of interlaced, electricallyconductive filaments34. In some embodiments, braidedconductive member28 is a wire mesh. Thefilaments34 are preferably formed of metallic elements having relatively small cross sectional diameters, such that the filaments are flexible and the braided conductive member can be expanded radially outwardly. In one embodiment, the filaments may be round in cross-section, having a dimension on the order of about 0.001-0.030 inches in diameter. Alternatively, the filaments may have flat sides in cross-section, with thicknesses on the order of about 0.001-0.030 inches, and widths on the order of about 0.001-0.030 inches. The filaments may be formed of nitinol-type wire or other shaped memory alloys. Alternatively, the filaments may include non-metallic elements woven with metallic elements, with the non-metallic elements providing support to and/or separation of the metallic elements. A multiplicity ofindividual filaments34 may be provided in braidedconductive member28, for example three hundred or more filaments. Instead of a multiplicity or plurality of filaments, a smaller number of filaments, or even only one continuous filament may be arranged to form braidedconductive member28. For purposes herein, the terms “filaments” or “plurality of filaments” may refer to one continuous filament that is interlaced with itself to form a braided conductive member.
• Each of thefilaments34 may be electrically isolated from each other by an insulation coating. This insulation coating may be, for example, a polyamide type material. In one manner of forming an electrode, a portion of the insulation on the filaments forming an outer circumferential surface of braidedconductive member28 is removed. This arrangement allows each of thefilaments34 to form an isolated electrode, not in electrical contact with any other filament, that may be used for mapping and ablation. In some embodiments, an electrode may contact a coated section of another filament. Alternatively, specific electrodes may be permitted to contact each other to form a preselected grouping. Methods of removing insulation fromfilaments34 are disclosed in PCT Publication No. WO 02/087437, which is herein incorporated by reference in its entirety. The insulation may also be removed in a preferential manner so that a particular portion of the circumferential surface of afilament34 is exposed. In this manner, when braidedconductive member28 is radially expanded, the stripped portions of filaments may preferentially face an intended direction of mapping or ablation.
• Further, in some embodiments some offilaments34 may be used for mapping or electrical measurement, while others offilaments34 may be used for ablation. The mapping and ablation filaments may be activated independently or may be activated concurrently. One application of dedicating some filaments for mapping and others for ablation is using a single braidedconductive member28 to both form a lesion and measure the quality of the lesion. Such an arrangement can avoid a change of catheters during a medical procedure. Temperature sensors (not shown) also may be included oncatheter shaft12 or braidedconductive member28.
• A wire (not shown) may run from each of thefilaments34 toconnector portion16 via conductors (not shown). A multiplexer or switch box (see, for example,switch matrix1230,FIG. 12) may be connected to the conductors so that eachfilament34 may be controlled individually. This function may be incorporated intocontroller8. In some embodiments, a number offilaments34 may be grouped together for mapping and ablation. Alternatively, eachindividual filament34 may be used as a separate mapping channel for mapping individual electrical activity at a single point. Using a switch box or multiplexer to configure the signals being received byfilaments34 or ablation energy sent tofilaments34 results in a large number of possible combinations of filaments for detecting electrical activity during mapping procedures and for applying energy during an ablation procedure.
• Catheter10 may also have a reference electrode (not shown) mounted onshaft12 so that the reference electrode is located outside the heart during unipolar mapping operations.
• Individual control of the electrical signals received fromfilaments34 allowscatheter10 to be used for bipolar (differential or between filament) type mapping as well as unipolar (one filament with respect to a reference electrode) type mapping.
• Catheter10 may be a steerable device, in some embodiments, in that thedistal end26 may be deflected by an actuator contained within control handle14. Control handle14 may include a rotatable thumb wheel which can be used by a user to deflectdistal end26 of the catheter. The thumb wheel (or any other suitable actuating device) is connected to one or more pull wires (not shown) which extend throughshaft portion12 and connect todistal end18 of the catheter at an off-axis location, whereby tension applied to one or more of the pull wires causes the distal portion of the catheter to curve in a predetermined direction or directions. U.S. Pat. Nos. 5,383,852, 5,462,527, and 5,611,777 illustrate various embodiments of control handle14 that may be used for steeringcatheter10.
• In some embodiments, a proximal portion of braidedconductive member28 includes support elements to aid in maintaining the shape and/or structural integrity of portions of braidedconductive member28 whendistal end18 is moved in the proximal direction. For example, support elements may includesupport filaments34′ that are stronger, thicker or more rigid at their proximal ends than at their distal ends, as illustrated inFIG. 6. In other embodiments, splines35 or other non-filament elements may be included, such as by interlacing support elements amongfilaments34, as illustrated inFIG. 7. In still further embodiments, support elements which are not interlaced withfilaments34 may be included. In some embodiments, support elements attach to aproximal anchoring element32 at a first end and to cap24 orfilaments34 at a second end.
• Referring toFIG. 7, an embodiment of the invention having a longitudinally asymmetrically shaped braidedconductive member28 is illustrated. In this embodiment, amaximum diameter36 of braidedconductive member28 is located closer todistal end18 than toproximal anchoring element32. In one embodiment,maximum diameter36 is longitudinally located more than two-thirds of the way from the proximal anchoring location to the distal attachment location. Ascable22 is drawn in the proximal direction to movecap24, splines35 support the more proximal region of braidedconductive member28.
• Reference is now made toFIG. 8 which illustrates another shape of braidedconductive member28. As described above regarding various embodiments of the invention, braidedconductive member28 may be generally radially symmetrical. However, certain anatomical structures may have complex three-dimensional shapes that are not easily approximated by a geometrically symmetrical mapping or ablation structure. To successfully contact these types of anatomical structures, braidedconductive member28 can be “preformed” to a close approximation of that anatomy, and yet still be flexible enough to adapt to variations found in specific patients. Alternatively, braidedconductive member28 can be of sufficient strength (as by choice of materials, configuration, etc.) to force the tissue to conform to variations found in specific patients. For example,FIG. 8 illustrates braidedconductive member28 disposed aboutshaft12 in an off-center or non-concentric manner such that braidedconductive member28 is radially asymmetrically-shaped. In addition, braidedconductive member28 may also be constructed so that the annular surface of the braided conductive member in its expanded configuration is a non-circular surface so as to improve tissue contact.FIG. 8 illustrates an example of this type of configuration where the braidedconductive member28 is constructed and arranged to be non-concentric with respect to a longitudinal axis of braidedconductive member28 and also, in its expanded configuration, to have an asymmetric shape. In some embodiments, the asymmetric expanded configurations and the eccentricity of braidedconductive member28 with respect to the longitudinal axis can be produced by providing additional structural supports in braidedconductive member28, for example, by adding nitinol wire, ribbon wire, splines, and so on. Other suitable methods of creating the eccentric and/or asymmetric shape include: varying the winding pitch; varying individual filament size and/or placement; deforming selective filaments in braidedconductive member28; and any other suitable method known to those skilled in the art.
• An asymmetrically-shaped braided conductive member may allow for the formation of a ring-shaped surface that is disposed at an angle to general longitudinal direction of the braided member and/or the distal end of the catheter. The angled surface may permit better contact with certain tissue areas. In still other embodiments, inverting the braided conductive member may form a non-planar surface. For example, differing filament diameters may allow for the formation of a ring-shaped surface which includes a section that is substantially perpendicular to the catheter and a section that is disposed at an angle to the catheter. The angle of the surface relative to the catheter may change continuously across the surface in still other embodiments.
• In some embodiments of the present invention,catheter10 may be coated with a number of coatings that enhance the operating properties of braidedconductive member28. The coatings may be applied by any of a number of techniques and the coatings may include a wide range of polymers and other materials.
• Braidedconductive member28 may be coated to reduce its coefficient of friction, thus reducing the possibility of thrombi adhesion to the braided conductive member as well as the possibility of vascular or atrial damage. These coatings can be combined with insulation (if present) on the filaments that make up braidedconductive member28. These coatings may be included in the insulation itself, or the coatings may be applied over the insulation layer.
• Braidedconductive member28 also may be coated to increase or decrease its thermal conduction, which can improve the safety or efficacy of the braidedconductive member28. This change in thermal conduction may be achieved by incorporating thermally conductive elements or thermally insulating elements into the electrical insulation of the filaments that make up braidedconductive member28, or by adding a coating to the assembly. Polymer mixing, IBAD, or similar technology could be used to add Ag, Pt, Pd, Au, Ir, Cobalt, and others into the insulation or to coat braidedconductive member28.
• In some embodiments, radioopaque coatings or markers may be used to provide a reference point for orientation of braidedconductive member28 when viewed during fluoroscopic imaging. The materials that provide radiopacity include, for example, Au, Pt, Ir, and others known to those skilled in the art. These materials may be incorporated and used as coatings as described above.
• Antithrombogenic coatings, such as heparin and BH, can also be applied to braidedconductive member28 to reduce thrombogenicity to prevent blood aggregation on braidedconductive member28. These coatings can be applied by dipping or spraying, for example.
• As noted above, thefilament34 of braidedconductive member28 may be constructed of metal wire materials. These materials may be, for example, MP35N, nitinol, or stainless steel.Filaments34 may also be composites of these materials in combination with a core of another material such as silver or platinum. The combination of a highly conductive electrical core material with another material forming the shell of the wire allows the mechanical properties of the shell material to be combined with the electrical conductivity of the core material to achieve better and/or selectable performance. The choice and percentage of core material used in combination with the choice and percentage of shell material used can be selected based on the desired performance characteristics and mechanical/electrical properties desired for a particular application.
• There may be times during ablation or mapping procedures whencatheter10 passes through difficult or tortuous vasculature. During these times, it may be helpful to have a guiding sheath (not shown) through which to passcatheter10 so as to allow easier passage through the patient's vasculature.
• Irrigation
• It is known that for a given electrode side and tissue contact area, the size of a lesion created by radiofrequency (RF) energy is a function of the RF power level and the exposure time. At higher powers, however, the exposure time can be limited by an increase in impedance that occurs when the temperature at the electrode-tissue interface approaches 100° C. One way of maintaining the temperature less than or equal to this limit is to irrigate the ablation electrode with saline to provide convective cooling so as to control the electrode-tissue interface temperature and thereby prevent an increase in impedance. Accordingly, irrigation of braidedconductive member28 and the tissue site at which a lesion is to be created can be provided in the present invention.FIG. 9 illustrates the use of an irrigation manifold within braidedconductive member28. Anirrigation manifold100 is disposed alongshaft12 inside braidedconductive member28.Irrigation manifold100 may be one or more polyimide tubes. Within braidedconductive member28, the irrigation manifold splits into a number ofsmaller tubes102 that are woven into braidedconductive member28 along arespective filament34. A series ofholes104 may be provided in each of thetubes102. These holes can be oriented in any number of ways to target a specific site or portion of braidedconductive member28 for irrigation.Irrigation manifold100 runs throughcatheter shaft12 and may be connected to an irrigation delivery device outside the patient used to inject an irrigation fluid, such as saline, for example, such as during an ablation procedure.
• The irrigation system can also be used to deliver a contrast fluid for verifying location or changes in vessel diameter. For example, a contrast medium may be perfused prior to ablation and then after an ablation procedure to verify that there have been no changes in the blood vessel diameter. The contrast medium can also be used during mapping procedures to verify placement of braidedconductive member28. In either ablation or mapping procedures, antithrombogenic fluids, such as heparin can also be perfused to reduce thrombogenicity.FIG. 10 illustrates another way of providing perfusion/irrigation incatheter10. As illustrated inFIG. 10, thefilaments34 that comprise braidedconductive member28 may be composed of acomposite wire110. Thecomposite wire110 includes alumen114 containing an electricallyconductive wire112 that is used for delivering ablation energy in an ablation procedure or for detecting electrical activity during a mapping procedure.Composite wire110 also contains aperfusion lumen116.Perfusion lumen116 is used to deliver irrigation fluid or a contrast fluid as described in connection withFIG. 9. Once braidedconductive member28 has been constructed withcomposite wire110, theinsulation118 surroundingwire filament112 can be stripped away to form an electrode surface. Holes can then be provided inperfusion lumen116 to then allow perfusion at targeted sites along the electrode surface. As with the embodiment illustrated inFIG. 9, the perfusion lumens can be connected together to form a manifold which manifold can then be connected to, for example,perfusion tube120 and connected to a fluid delivery device.
• Methods of Use
• Reference is now made toFIG. 11 which illustrates how a catheter according to certain embodiments of the present invention may be used in endocardial applications.
• In an endocardial procedure,shaft portion12 is introduced into a patient'sheart150. Appropriate imaging guidance (direct visual assessment, camera port, fluoroscopy, echocardiographic, magnetic resonance, etc.) can be used.FIG. 11 in particular illustratesshaft portion12 being placed in the left atrium of the patient's heart, though a catheter using a braidedconductive member28 is well suited for mapping and ablating in other structures, such as ventricles, particularly near the ventricular outflow tract. Onceshaft portion12 reaches the patient's left atrium,sheath33 may be retracted and braidedconductive member28 may be inverted to its deployed state, where, in the illustrated embodiment, braidedconductive member28 forms a cone-type shape including a distally-facing, ring-shaped surface. External pressure may be applied alongshaft portion12 to achieve the desired level of contact between braidedconductive member28 and the cardiac tissue. In one embodiment, mapping of electrical impulses may be achieved with braidedconductive member28. In another embodiment, energy is applied to the cardiac tissue in contact with braidedconductive member28 to create an annular lesion. The energy used may be RF (radiofrequency), DC, microwave, ultrasonic, cryothermal, optical, etc.
• In some embodiments, the braided conductive member may be configured such that it forms a distally-facing, ring-shaped surface before the braided conductive member is introduced to the heart.
• Controller
• FIG. 12 shows further details of an embodiment of thecontroller8 ofFIG. 1. In this embodiment, the controller includes acomputer1210.Computer1210 has adisplay1216 through whichcomputer1210 may provide a graphical user interface through which a user may input commands or receive information gathered by the electrophysiology system. For example, the user interface allows a user to operate the system to apply electrical signals to braidedconductive member28 during a method of diagnosing or treating an arrhythmia.
• Computer1210 may be used in the performance of procedures and data processing operations, such as are described in copending patent applications, such as an application entitled METHODS FOR PROCESSING ELECTROCARDIAC SIGNALS HAVING SUPERIMPOSED COMPLEXES published as US 2002-0091330 A1 on Jul. 11, 2002; an application entitled SOFTWARE CONTROLLED ELECTROPHYSIOLOGY DATA MANAGEMENT published as US 2002-0065459 A1 on May 30, 2002; an application entitled MULTI-COLOR DISPLAY OF CLOSELY PROXIMATE AND OVERLAPPING CARDIAC SIGNALS, published as WO 2005/008418 A2 on Jan. 27, 2005, all of which are hereby incorporated by reference.
• Computer1210 may be a standard computer, such as is widely used in business settings, with a standard operating system that executes desired application programs. Such a computer may be equipped with data acquisition and control boards, as are known in the art, to receive data and control other components of a system. Alternatively,computer1210 may be a custom designed computer having a form factor and other characteristics customized for use in an electrophysiology laboratory. Such a computer may contain one or more general purpose or special purpose processors that may be integrated with data acquisition and control hardware. However, the specific construction ofcomputer1210 is not a limitation of the invention.
• Computer1210 includes user input devices which may include a touch pad, a touch screen, a pointing wheel, buttons and/or other devices. In the illustrated embodiment,computer1210 includes akeyboard1212 and amouse1214 that serve as user input devices.Mouse1214 may serve as a user interface selection device that works in cooperation with a graphical user interface presented ondisplay1216. A user may use known motions, such as movingmouse1214 to place a cursor over an object appearing as part of the graphical user interface and “clicking” on the object to invoke a function associated with that object.
• Computer1210 typically includes at least some form of computer readable media. Computer readable media can be any available media that can be accessed byComputer1210. By way of example, and not limitation, computer readable media may comprise computer storage media and communication media. Computer storage media includes volatile and nonvolatile, removable and non-removable media implemented in any method or technology for storage of information such as computer readable instructions, data structures, program modules or other data. Computer storage media includes, but is not limited to, RAM, ROM, EEPROM, flash memory or other memory technology, CD-ROM, digital versatile disks (DVD) or other optical storage, magnetic cassettes, magnetic tape, magnetic disk storage or other magnetic storage devices, or any other medium which can be used to store the desired information and which can accessed byComputer1210. Communication media typically embodies computer readable instructions, data structures, program modules or other data in a modulated data signal such as a carrier wave or other transport mechanism and includes any information delivery media. Combinations of the any of the above should also be included within the scope of computer readable media.
• Computer-readable media may contain computer-executable instructions that causecomputer1210 to generate signals that control operation of the electrophysiology system or to gather and process data from the system. Computer-executable instructions may be in multiple forms, such as program modules, executed by one or more computers or other devices. Generally, program modules include routines, programs, objects, components, data structures, etc. that perform particular tasks or implement particular abstract data types. Typically the functionality of the program modules may be combined or distributed as desired in various embodiments.
• The computer-executable instructions may programcomputer1210 to perform multiple functions as are known in the art or are as described in greater detail herein.Computer1210 may, for example, issue control signals to configure braidedconductive member28 to perform specific operations. Braidedconductive member28 includes multiple electrically active sites. In use, the electrically active sites may be used to apply electrical signals or measure signals from a heart or other structure in contact with a surface of braidedconductive member28. Such electrically active sites may, for example, be formed by stripping insulation from conductive filaments forming braidedconductive member28. Braidedconductive member28 may be configured by connecting selected ones of the conductingfilaments34 to specific components of the electrophysiology system.Switch matrix1230 allows these connections to be made under control ofcomputer1210.
• In the illustrated embodiment, the electrophysiology system includes an RF generator124 that may be used to generate an RF signal for ablation. RF generator124 may be connected throughswitch matrix1230 tocable6, which contains wires that connect to the electricallyconductive filaments34.Switch matrix1230 may be controlled bycomputer1210 to connect RF generator124 to any one or more of the electricallyconductive filaments34. In this embodiment,RF controller1242 is used to extract information from connections made throughcatheter10. For example,controller1242 may detect impedances and temperates at the catheter to monitor an ablation process.RF controller1242 may also be used to control the power level applied. For example,controller1242 may provide a lower power while the system ofFIG. 12 is configured for pace mapping and a higher power when the system is configured for ablation.
• Similarly,recording device2 is coupled throughswitch matrix1230 tocable6. In this way, computer-executable instructions associated withcomputer1210 may configure, at any time, each of the electrically active sites to provide a stimulus signal to apply an ablation signal, to take a measurement or to perform no function.
• Computer1210 may also receive inputs from other components of the electrophysiology system. For example,computer1210 is shown connected to anavigation system1250.Navigation system1250 may be a navigation system as is known in the art. Such a system may output values representing the position of a catheter during a mapping or ablation procedure.Computer1210 may also receive inputs fromECG system1260. Such a system may be used in a pace mapping procedure. During pace mapping, stimulus signals provided to the heart throughcatheter10 may be detected externally throughECG system1260.Computer1210, may use this information to determine whether the applied stimulus triggered a response that is similar to the ECG measured for a patient during an arrhythmia episode.
• Computer1210 provides a user interface ondisplay1216 that may facilitate the use of electrophysiology system as pictured inFIG. 12, particularly one that includes a catheter that can be configured. In particular, braidedconductive member28 provides a substrate on which multiple electrically active sites are mounted. In use, the catheter is configured by selectively accessing groups of the electrically active sites.
• FIGS. 13A and 13B illustrate an embodiment in which a graphical user interfaced is used in configuring a catheter. The graphical user interface allows the electrically active sites to be accessed in one of multiple ways. Each electrically active site may be accessed individually. Alternatively, the electrically active sites may be formed into groups. The groups may then be accessed individually or may be accessed according to a pattern specified by a user.
• Turning toFIG. 13A, awindow1310 such as may appear ondisplay1216 is illustrated.Window1310 includes amenu bar1330 that allows a user to specify the operating mode of the electrophysiology system in which the site groupings specified are used. In this example, the electrophysiology system may be used for passive mapping, pace mapping or ablation. Accordingly,menu bar1330 includes acontrol1332, allowing the user to specify a configuration for passive mapping procedures.Window1310 likewise includescontrols1334 and1336 which allow the user to specify a site group for pace mapping procedures and ablation procedures, respectively.Window1310 includesgraphical component1320 representing the catheter. The individual electrically active sites are indicated by controls such as those indicated at1322A and1322B. In this embodiment, each electrically active site has a corresponding control displayed inwindow1310.
• In the mode displayed inFIG. 13A, a user may access an electrically active site individually. Any suitable method may be used to receive user input indicating a selection of a specific electrically active site. In the illustrated embodiment, traditional “point and click” commands are used. A user may manipulatemouse1214 or other user input selection device attached tocomputer1210 to position acurser1340 over the control indicating the selective electrically active site. By “clicking” the mouse or otherwise indicating a selection, the user may specify that the electrically active site corresponding to the control be accessed.
• Such a user interface may be implemented using programming techniques as are known in the art. For example, traditional software systems with graphical user interfaces associate program elements with controls appearing on a computer display. When a user selects a specific control, the software associated with the control is executed. In the example ofFIG. 13A, selecting a control representing an electrically active site may, for example, execute software oncomputer1210 that sends a signal to switchmatrix1230 to connect that electrically active site toRF generator1240. However, the specific action taken in response to a user selection of an electrically active site may depend on the operating mode selected. For example, when the user has selected a passive mapping operating mode throughmenu choice1332, the software executed in response to this selection may connect the selectively active site torecording device2.
• FIG. 13B shows an alternative user interface that may be used to access electrically active sites in groups.FIG. 13B shows awindow1350 that may, for example, appear ondisplay1216 as part of a graphical user interface presented to an operator of the electrophysiology system ofFIG. 12.Window1350 includes multiple controls, each representing a group of electrically active sites on a catheter that is used in connection with the electrophysiology system. In the illustrated example controls1351,1352 and1353 are shown, representing three subgroups of electrically active sites that have been defined. However, the number of groups is not a limitation on the invention.Computer1210 may be programmed to add or remove controls as subgroups of electrically active sites are defined.
• FIG. 13B shows one way in which electrically active sites may be assigned to each of the subgroups. A drop downlist box1360 is shown in connection withcontrol1353 corresponding to one of the groups of electrically active sites. In this example, drop downlist1360 includes an entry for each possible electrically active site that may be added to the third subgroup. For simplicity of illustration onlyentries1361 and1362 are numbered. Each entry such as1361 and1362 includes a checkbox such as1371 or1372. The check box may itself be a control through which a user using the graphical user interface may provide input. By “clicking” on the checkbox, a user may specify that a site belongs to the group. By “clicking” on a checkbox that is already checked, the user may specify that a site should be removed from the group.
• A drop down list box may be associated with each of thecontrols1351,1352 and1353 may be accessed in any suitable way. Where a multi-button mouse is used, the drop down list such as drop downlist1360, for example, may be accessed by pressing the right button on the mouse whencurser1340 is positioned over a control such as1353. However, any suitable method of assigning electrically active sites to groups, including receiving text input, may be used.
• Once groups of electrically active sites have been defined, the groups may be used in controlling the electrophysiology system. For example, accessing one of the controls through the user interface, such as by “clicking” on one of thecontrols1351,1352 or1353, may cause all of the electrically active sites defined to be in the group to be accessed. In a pace mapping mode, accessing a group may cause all of the electronically active sites in that group to be connected toRF generator1240 throughswitch matrix1230. In passive mapping mode, accessing a group may cause each of the electrically active sites in that group to be connected through switch matrix1232 torecording device2.
• Once groups of electrically active sites have been defined, groups may be accessed in an order and with the timing specified by the user. One way for a user to specify the timing and access to groups of sites is by manipulating curser1340 to indicate one of the controls such as1351,1352, or1353 associated with a group. The user may manually use a selection device, such as a button onmouse1214, to select the control. Upon selecting a control, the electrically active sites in the group associated in the group associated with that control may be accessed. In this way, the groups will be accessed in an order specified by the user at times specified by the user.
• Computer1210 may alternatively be programmed to provide an alternative method for a user to specify the order and timing of access to groups of electrically active sites. For example,computer1210 may implement a user interface in which the controls such ascontrol1351,1352, and1353 are movable objects on the graphical user interface. In this embodiment, the user may specify the order of access to the groups by moving the controls into a desired order.
• The user may specify timing of access to the groups in any suitable way. For example,computer1210 may provide a user interface with an input section (not shown), through which the user may specify a time when each group of electrically active sites is accessed. Alternatively,computer1210 may receive inputs that specify the duration for which each group is accessed or the delay between accesses of successive groups. The information about ordering and timing of access to the groups, regardless of how specified by the user, creates a form of program that may be executed by the electrophysiology system ofFIG. 12. Accordingly,window1350 includes a control1370 that the user may access. Access and control1370 may, for example, invoke a program that accesses groups of electrically active sites in the order and with the timing specified by the user. Such a function may be used in the course of a mapping procedure to gather data intended to identify the focus of an arrhythmia. Alternatively, such a procedure may be used in connection with an ablation procedure where the focus of the arrhythmia has been identified and a specific pattern of applied RF energy has been selected for treating the arrhythmia.
• Turning now toFIG. 14, a process of accessing groups of electrically active sites is illustrated. The process ofFIG. 14 may, for example, be implemented by software programmed incomputer1210. The process begins atblock1410 where a group is specified. A group may be specified by input from a user. The user input may be obtained through a graphical user interface as depicted inFIGS. 13A and 13B. However, any suitable method of specifying a group may be used.
• The process illustrated inFIG. 14 continues todecision block1412. If it is determined atdecision block1412 that further groups remain to be specified, processing loops back tostep1410.
• When there are no further groups to specify, processing continues to block1414. Atblock1414, the electrophysiology system waits until the programmed time for the first group to be processed is reached. At the programmed time, processing proceeds to block1416. Atblock1416 the electrophysiology system is configured for the group being processed. In the example ofFIG. 12, configuration may include providing control information to switchmatrix1230. Other devices within the electrophysiology system may likewise be controlled to obtain the desired configuration.
• Atblock1418, the desired function of the electrophysiology system is applied. In this block, the function may be applied by providing an RF signal of the appropriate magnitude or by making a measurement from each of the electrically active sites in the subgroup, depending on the specific operating mode of the system.
• The process proceeds todecision block1420. Atdecision block1420 it is determined if there are more groups of electrically active sites to be processed. If more groups remain, processing returns to block1414. The process waits atblock1414 until the time for processing the next group. At that time, the process inblocks1416,1418, anddecision block1420 is repeated.
• In this way, the electrophysiology system allows a user to control a catheter with electrically multiple active sites. Flexible control is provided to allow the user to access these sites singly or in groups and in a manual or automated fashion. Such control capability when combined with a catheter that has multiple electrically active sites on a substrate that may cover a relatively large area, speeds procedures performed with the electrophysiology system.
• For example, the above described U.S. Published application, US 2002/0065459-A1, entitled “SOFTWARE CONTROLLED ELECTROPHYSIOLOGY DATA MANAGEMENT” describes the use of a roving catheter. That patent application describes managing discrete data capture requests throughout the course of an electrophysiology procedure. A catheter as described above having a plurality of electrically active sites that may be selected in groups may be used in place of a roving catheter. Rather than repositioning a roving catheter between independent data capture events, different groups of the electrically active sites may be selected without moving the catheter. The selection of groups may be made in response to manual user inputs or may be performed programmatically based on a predefined sequence for accessing groups of electrically active sites.
• As another example, published U.S. Patent Application US 2002/0091330-A1, entitled “METHODS FOR PROCESSING ELECTROCARDIAC SIGNALS HAVING SUPERIMPOSED COMPLEXES” describes a reference ECG waveform compared to an ECG waveform captured during pace mapping. As part of such a method, a quality of match indicator is computed. For pace mapping, the heart is stimulated with a roving intercardiac catheter. A catheter having a plurality of individually accessible electrically active sites as described above may be used to perform such a procedure without moving a roving catheter. Rather, stimulus may be provided to the heart in a predictable, defined manner by selecting groups of the electrically active sites on a single catheter.
• More generally the catheter and controller described above may be used in any procedure where accessing different locations is desired. The access may be to sense signals in a passive mapping procedure. Alternatively, the access may be to supply signals, such as in a pace mapping or ablation process. Regardless of the specific purpose of the access, allowing access in a predictable, defined manner is advantageous. It avoids the random “hit and miss” approach that characterizes many current procedures in which locations in the heart are accessed through manipulation of a tip of a catheter.
• Having thus described several aspects of at least one embodiment of this invention, it is to be appreciated that various alterations, modifications, and improvements will readily occur to those skilled in the art. Such alterations, modifications, and improvements are intended to be part of this disclosure, and are intended to be within the spirit and scope of the invention. Accordingly, the foregoing description and drawings are by way of example only.

Claims (17)

1. A computer-readable medium comprising computer-executable instructions for controlling an electrophysiology system of the type having a catheter with a plurality of electrically active sites, the computer-executable instructions for performing acts of:

(a) providing at least one display area through which a user may specify a set of the electrically active sites to be used in sensing signals from a heart;

(b) providing at least one display area through which a user may specify a set of the electrically active sites to be used in sending stimulation signals to the heart; and

(c) providing at least one display area through which a user may specify a set of the electrically active sites to be used in sending an ablation signal to the heart.

2. The computer-readable medium ofclaim 1, wherein the act (a) comprises providing at least one display area having a graphical representation of the plurality of electrically active sites.

3. The computer-readable medium ofclaim 2, wherein providing a graphical presentation of each of the plurality of electrically active sites comprises displaying on a computer display a control associated with the plurality of electrically active sites.

4. The computer-readable medium ofclaim 1, wherein the act (a) comprises providing at least one display area in response to a user selection of a passive mapping mode.

5. The computer-readable medium ofclaim 1, wherein the act (c) comprises providing at least one display area in response to the user activating a control to place the electrophysiology system in a ablation mode.

6. A computer-readable medium comprising computer-executable instructions for controlling an electrophysiology system of the type having a catheter with a plurality of electrically active sites, the computer-executable instructions for performing acts of:

(a) for each of a plurality of sets of electrically active sites, receiving from a user a specification of the electrically active sites in the set;

(b) receiving from the user a specification of a specified order of the plurality of sets; and

(c) for each of the sets, successively in the specified order, controlling the electrophysiology system to access the electrically active sites of the set.

7. The computer-readable medium ofclaim 6, wherein the act (a) comprises the acts of:

(i) providing a graphical user interface displaying a visual representation of the catheter and the plurality of electrically active sites; and

(ii) receiving user input through the graphical user interface specifying selected ones of the electrically active sites.

8. The computer-readable medium ofclaim 6, wherein the act (b) comprises the acts of:

(i) providing a graphical user interface with a selection area associated with each of the plurality of sets;

(ii) receiving a plurality of successive user inputs indicating a selection area; and

(iii) deriving the specified order of sets from an order in which the user accesses the specification areas.

9. The computer-readable medium ofclaim 8, wherein the act (c) comprises controlling the electrophysiology system to access the electrically active sites of the set as each of the plurality of successive user inputs is received.

10. The computer-readable medium ofclaim 8, wherein the act (c) comprises the acts of:

(i) recording the order of the plurality of user inputs at a first time; and

(ii) at a second time, later than the first time, for each of the sets, successively in the recorded order, controlling the electrophysiology system to access the electrically active sites of the set.

11. The computer readable medium of10, wherein the computer executable instructions additionally perform the act of:

(d) capturing an ECG waveform in synchronization with successive accesses for each of the sets of electrically active sites.

12. In an electrophysiology system having a catheter with a plurality of electrically active sites and a computer having a graphical user interface including a display and a user interface selection device, a method of providing and selecting from a menu on the display, comprising the acts of:

(a) displaying on the display a graphical representation of each of the plurality of electrically active sites on the catheter;

(b) receiving at least one selection signal indicative of the user interface selection device pointing at a graphical representation of a selected one of the plurality of electrically active sites; and

(c) controlling the electrophysiology system to selectively access at least one of the electrically active sites based on the at least one selection signal.

13. The electrophysiology system ofclaim 12, wherein the act (c) comprises controlling the electrophysiology system to selectively apply a stimulus signal to at least one of the electrically active sites based on the at least one selection signal.

14. The electrophysiology system ofclaim 12, wherein the act (c) comprises controlling the electrophysiology system to selectively apply a pace mapping signal.

15. The electrophysiology system ofclaim 13, wherein the act (c) comprises controlling the electrophysiology system to selectively apply an ablation signal.

16. The electrophysiology system ofclaim 13, wherein the method additionally comprises the act of:

(d) capturing data in conjunction with the selective access of the at least one of the electrically active sites.

17. The electrophysiology system ofclaim 12, wherein:

the method additionally comprises the act of (d) receiving a user input specifying an operating mode of the system; and

the act (c) comprises selectively driving or receiving a signal through at least one of the electrically active sites based on the user input specifying an operating mode.

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