US20070270750A1 - Drug delivery device - Google Patents
Drug delivery deviceDownload PDFInfo
- Publication number
- US20070270750A1 US20070270750A1US11/435,906US43590606AUS2007270750A1US 20070270750 A1US20070270750 A1US 20070270750A1US 43590606 AUS43590606 AUS 43590606AUS 2007270750 A1US2007270750 A1US 2007270750A1
- Authority
- US
- United States
- Prior art keywords
- handpiece
- tip
- drug
- delivery device
- drug delivery
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000012377drug deliveryMethods0.000titleclaimsdescription11
- 230000007246mechanismEffects0.000claimsdescription11
- 239000003814drugSubstances0.000abstractdescription24
- 229940079593drugDrugs0.000abstractdescription24
- 239000007788liquidSubstances0.000abstractdescription11
- 230000007704transitionEffects0.000abstractdescription11
- 238000010276constructionMethods0.000description6
- 208000002780macular degenerationDiseases0.000description4
- 206010064930age-related macular degenerationDiseases0.000description3
- 238000002347injectionMethods0.000description3
- 239000007924injectionSubstances0.000description3
- 230000000649photocoagulationEffects0.000description3
- 201000004569BlindnessDiseases0.000description2
- 229940121369angiogenesis inhibitorDrugs0.000description2
- 239000004037angiogenesis inhibitorSubstances0.000description2
- 239000011521glassSubstances0.000description2
- 239000002184metalSubstances0.000description2
- 238000000034methodMethods0.000description2
- 210000001525retinaAnatomy0.000description2
- 206010025421MaculeDiseases0.000description1
- 239000013543active substanceSubstances0.000description1
- 210000004204blood vesselAnatomy0.000description1
- 238000005516engineering processMethods0.000description1
- 230000008713feedback mechanismEffects0.000description1
- 239000012530fluidSubstances0.000description1
- 239000007943implantSubstances0.000description1
- 238000012986modificationMethods0.000description1
- 230000004048modificationEffects0.000description1
- 230000000750progressive effectEffects0.000description1
- 230000000306recurrent effectEffects0.000description1
- 230000000717retained effectEffects0.000description1
Images
Classifications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
- A61M5/14546—Front-loading type injectors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0266—Shape memory materials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/82—Internal energy supply devices
- A61M2205/8206—Internal energy supply devices battery-operated
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/82—Internal energy supply devices
- A61M2205/8262—Internal energy supply devices connectable to external power source, e.g. connecting to automobile battery through the cigarette lighter
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0612—Eyes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/48—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for varying, regulating, indicating or limiting injection pressure
- A61M5/484—Regulating injection pressure
Definitions
- the present inventiongenerally pertains to the delivery of ophthalmically acceptable pharmaceutically active agents to the back of the eye and more particularly to an apparatus for delivery of precise amounts of a liquid or phase transition drug under controlled back pressure and flow conditions.
- Age related macular degenerationis the leading cause of blindness in the elderly. It attacks the center of vision and blurs it, making reading, driving, and other detailed tasks difficult or impossible. Current estimates reveal that approximately forty percent of the population over age 75, and approximately twenty percent of the population over age 60, suffer from some degree of macular degeneration. In “wet” ARMD, the type that most often causes blindness, newly formed choroidal blood vessels (CNV) leak fluid and cause progressive damage to the retina. Two main methods of treatment are currently being performed, (a) photocoagulation and (b) the use of angiogenesis inhibitors.
- CNVchoroidal blood vessels
- Photocoagulationcan be harmful to the retina and is impractical when the CNV is in proximity of the fovea. Furthermore, photocoagulation often results in recurrent CNV over time.
- Angiogenesis inhibitorsmay be administered orally, by intraocular injections, by extraocular sub-Tennon injections, or by local implants.
- a physiciandisposes the tip of a curved needle externally around the eye near the macula, and releases a precise amount of the drug.
- a concern with sub-Tenon deliveryis that the drug must be administered slowly and under relatively low pressure so as to be retained in the tissue rather than leaking back out, around the needle.
- the present inventionimproves upon the prior art by providing a syringe-like device having a drug dispensing tip connected to a motorized handpiece.
- the tipmay be packaged pre-loaded with an amount of a liquid or phase transition drug or may be shipped empty and loaded with a liquid or phase transition drug by the user.
- the motorized handpiececontains suitable sensors and controllers for precisely actuating the tip for the controlled delivery of the liquid or phase transition drug in the tip.
- the handpiecemay contain an internal power source, such as a battery, or may be connected to an external power source and/or control unit.
- one objective of the present inventionis to provide a syringe-like device having a drug dispensing tip.
- Another objective of the present inventionis to provide a device for the delivery of a drug to the human eye and having a drug dispensing tip actuated by a motorized handpiece.
- Yet another objective of the present inventionis to provide a drug delivery device wherein the flow rate of the drug being delivered can be controlled.
- FIG. 1is an enlarged, schematical view of a first embodiment of the drug deliver device of the present invention.
- FIG. 2is an enlarged, schematical view of a second embodiment of the drug deliver device of the present invention.
- drug delivery device 10 of the present inventiongenerally comprises tip 12 and handpiece 14 .
- Tip 12generally contains delivery cannula or needle 16 and body 18 .
- Needle 16may be any suitably sized needle of conventional construction.
- Body 18generally is of a construction similar to a standard hypodermic syringe, e.g., cylindrical and tubular, made from glass, metal or a suitable plastic. Body 18 is sized and shaped to hold a suitable amount of a liquid or phase transition drug.
- Handpiece 14generally is sized and shape similar to body 18 , e.g., cylindrical, and has distal end 20 adapted to allow tip 12 to be mechanically connected to handpiece 14 .
- Handpiece 14contains drive mechanism 22 , with associated driver electronics 24 , to push plunger 21 in body 18 to force the liquid or phase transition drug contained in body 18 out needle 16 .
- Suitable drive mechanismsinclude, for example, piezoelectric linear motors, such motors being well-known in the art (as described in U.S. Pat. No. 6,940,209 (Henderson)), and available from sources such as New Scale Technologies, Inc., Victor, N.Y.
- power for driver 22 and control electronics 24is provided from power source 26 , such as a battery, located internal to handpiece 14 .
- power source 26such as a battery, located internal to handpiece 14 .
- electronics 24can provide a feedback mechanism that senses the back pressure being exerted against the expression of the drug out of needle 16 and make appropriate adjustments to the speed and direction of motor 22 .
- drug delivery device 110 of the present inventionmay also generally comprise tip 112 and handpiece 114 .
- Tip 112generally contains delivery cannula or needle 116 and body 118 .
- Needle 116may be any suitably sized needle of conventional construction.
- Body 118is generally is of construction similar to a standard hypodermic syringe, e.g., cylindrical and tubular, made from glass, metal or a suitable plastic. Body 118 is sized and shaped to hold a suitable amount of a liquid or phase transition drug.
- Handpiece 114generally is sized and shaped similar to body 118 , e.g., cylindrical, and has distal end 120 adapted so allow tip 112 to be mechanically connected to handpiece 114 .
- Handpiece 114contains drive mechanism 122 , with associated driver electronics 124 , to push plunger 121 in body 118 to force the liquid or phase transition drug contained in body 118 out needle 116 .
- control electronics 124are located external to handpiece 114 and power and control signals are provided to drive mechanism 122 through cable 123 .
- Power for driver 122 and electronics 124is provided from external source 126 through electrical cable 128 . Such a construction allows for a smaller handpiece 114 .
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
Abstract
Description
- The present invention generally pertains to the delivery of ophthalmically acceptable pharmaceutically active agents to the back of the eye and more particularly to an apparatus for delivery of precise amounts of a liquid or phase transition drug under controlled back pressure and flow conditions.
- Age related macular degeneration (ARMD) is the leading cause of blindness in the elderly. It attacks the center of vision and blurs it, making reading, driving, and other detailed tasks difficult or impossible. Current estimates reveal that approximately forty percent of the population over age 75, and approximately twenty percent of the population over age 60, suffer from some degree of macular degeneration. In “wet” ARMD, the type that most often causes blindness, newly formed choroidal blood vessels (CNV) leak fluid and cause progressive damage to the retina. Two main methods of treatment are currently being performed, (a) photocoagulation and (b) the use of angiogenesis inhibitors.
- Photocoagulation can be harmful to the retina and is impractical when the CNV is in proximity of the fovea. Furthermore, photocoagulation often results in recurrent CNV over time.
- Angiogenesis inhibitors may be administered orally, by intraocular injections, by extraocular sub-Tennon injections, or by local implants. In the sub-Tenon injection method, a physician disposes the tip of a curved needle externally around the eye near the macula, and releases a precise amount of the drug. However, a concern with sub-Tenon delivery is that the drug must be administered slowly and under relatively low pressure so as to be retained in the tissue rather than leaking back out, around the needle.
- Therefore, a need exists in the field of ophthalmology for an improved apparatus for controlled delivery of a drug to the human eye.
- The present invention improves upon the prior art by providing a syringe-like device having a drug dispensing tip connected to a motorized handpiece. The tip may be packaged pre-loaded with an amount of a liquid or phase transition drug or may be shipped empty and loaded with a liquid or phase transition drug by the user. The motorized handpiece contains suitable sensors and controllers for precisely actuating the tip for the controlled delivery of the liquid or phase transition drug in the tip. The handpiece may contain an internal power source, such as a battery, or may be connected to an external power source and/or control unit.
- Accordingly, one objective of the present invention is to provide a syringe-like device having a drug dispensing tip.
- Another objective of the present invention is to provide a device for the delivery of a drug to the human eye and having a drug dispensing tip actuated by a motorized handpiece.
- Yet another objective of the present invention is to provide a drug delivery device wherein the flow rate of the drug being delivered can be controlled.
- Yet another objective of the present invention is to provide a drug delivery device wherein the amount of the drug being delivered can be controlled.
- These and other advantages and objectives of the present invention will become apparent from the detailed description and claims that follow.
FIG. 1 is an enlarged, schematical view of a first embodiment of the drug deliver device of the present invention.FIG. 2 is an enlarged, schematical view of a second embodiment of the drug deliver device of the present invention.- As best seen in
FIG. 1 ,drug delivery device 10 of the present invention generally comprisestip 12 andhandpiece 14.Tip 12 generally contains delivery cannula orneedle 16 andbody 18.Needle 16 may be any suitably sized needle of conventional construction.Body 18 generally is of a construction similar to a standard hypodermic syringe, e.g., cylindrical and tubular, made from glass, metal or a suitable plastic.Body 18 is sized and shaped to hold a suitable amount of a liquid or phase transition drug.Handpiece 14 generally is sized and shape similar tobody 18, e.g., cylindrical, and hasdistal end 20 adapted to allowtip 12 to be mechanically connected tohandpiece 14.Handpiece 14 containsdrive mechanism 22, with associateddriver electronics 24, to pushplunger 21 inbody 18 to force the liquid or phase transition drug contained inbody 18 outneedle 16. Suitable drive mechanisms include, for example, piezoelectric linear motors, such motors being well-known in the art (as described in U.S. Pat. No. 6,940,209 (Henderson)), and available from sources such as New Scale Technologies, Inc., Victor, N.Y. In the embodiment illustrated inFIG. 1 , power fordriver 22 andcontrol electronics 24 is provided frompower source 26, such as a battery, located internal tohandpiece 14. Such a construction allows for very precise and controlled movement ofplunger 21. In addition,electronics 24 can provide a feedback mechanism that senses the back pressure being exerted against the expression of the drug out ofneedle 16 and make appropriate adjustments to the speed and direction ofmotor 22. - As best seen in
FIG. 2 ,drug delivery device 110 of the present invention may also generally comprisetip 112 andhandpiece 114.Tip 112 generally contains delivery cannula or needle116 andbody 118. Needle116 may be any suitably sized needle of conventional construction.Body 118 is generally is of construction similar to a standard hypodermic syringe, e.g., cylindrical and tubular, made from glass, metal or a suitable plastic.Body 118 is sized and shaped to hold a suitable amount of a liquid or phase transition drug.Handpiece 114 generally is sized and shaped similar tobody 118, e.g., cylindrical, and hasdistal end 120 adapted so allowtip 112 to be mechanically connected tohandpiece 114.Handpiece 114 containsdrive mechanism 122, with associateddriver electronics 124, to pushplunger 121 inbody 118 to force the liquid or phase transition drug contained inbody 118 out needle116. In the embodiment illustrated inFIG. 2 ,control electronics 124 are located external tohandpiece 114 and power and control signals are provided to drivemechanism 122 throughcable 123. Power fordriver 122 andelectronics 124 is provided fromexternal source 126 throughelectrical cable 128. Such a construction allows for asmaller handpiece 114. - This description is given for purposes of illustration and explanation. It will be apparent to those skilled in the relevant art that changes and modifications may be made to the invention described above without departing from its scope or spirit.
Claims (6)
1. A drug delivery device, comprising:
a) a handpiece;
b) a tip having a body, the body being removably attached to the handpiece;
c) a cannula generally located on the body opposite the handpiece;
d) a plunger located in the tip body; and
e) a drive mechanism located in the handpiece, the drive mechanism providing movement of the plunger when the tip is connected to the handpiece.
2. The drug delivery device ofclaim 1 wherein the drive mechanism comprises a piezoelectric linear motor.
3. The drug delivery device ofclaim 1 wherein the handpiece further comprises an internal power source for the drive mechanism.
4. The drug delivery device ofclaim 1 wherein the handpiece further comprises internal control electronics for the drive mechanism.
5. The drug delivery device ofclaim 1 further comprising external control electronics for the drive mechanism.
6. The drug delivery device ofclaim 1 wherein the handpiece further comprises an external power source for the drive mechanism.
Priority Applications (30)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/435,906US20070270750A1 (en) | 2006-05-17 | 2006-05-17 | Drug delivery device |
| US11/688,573US7811252B2 (en) | 2006-05-17 | 2007-03-20 | Dosage control device |
| CA002588519ACA2588519A1 (en) | 2006-05-17 | 2007-05-15 | Drug delivery device |
| EP07108293AEP1857130A1 (en) | 2006-05-17 | 2007-05-15 | Drug delivery device |
| MX2007005846AMX2007005846A (en) | 2006-05-17 | 2007-05-16 | Drug delivery device. |
| TW096117365ATW200744558A (en) | 2006-05-17 | 2007-05-16 | Drug delivery device |
| BRPI0702340-5ABRPI0702340A (en) | 2006-05-17 | 2007-05-16 | drug delivery device |
| ARP070102129AAR061002A1 (en) | 2006-05-17 | 2007-05-17 | FARMACOS ADMINISTRATION DEVICE |
| JP2007131544AJP2007307376A (en) | 2006-05-17 | 2007-05-17 | Drug delivery device |
| CNA200710104927XACN101073682A (en) | 2006-05-17 | 2007-05-17 | Medicine conveying device |
| AU2007202216AAU2007202216A1 (en) | 2006-05-17 | 2007-05-17 | Drug delivery device |
| KR1020070048065AKR20070111394A (en) | 2006-05-17 | 2007-05-17 | Drug delivery devices |
| IL183295AIL183295A0 (en) | 2006-05-17 | 2007-05-17 | Drug delivery device |
| US11/752,011US20070270768A1 (en) | 2006-05-17 | 2007-05-22 | Mechanical Linkage Mechanism For Ophthalmic Injection Device |
| US11/752,064US7862540B2 (en) | 2006-05-17 | 2007-05-22 | Ophthalmic injection device using shape memory alloy |
| US11/751,981US7674243B2 (en) | 2006-05-17 | 2007-05-22 | Ophthalmic injection device using piezoelectric array |
| US11/751,934US20070268340A1 (en) | 2006-05-17 | 2007-05-22 | Ophthalmic Injection System and Method Using Piezoelectric Array |
| US11/762,844US7762981B2 (en) | 2006-05-17 | 2007-06-14 | Temperature release mechanism for injection device |
| US11/777,408US8821440B2 (en) | 2006-05-17 | 2007-07-13 | Dual thermal coefficient dispensing chamber |
| US11/832,333US7815603B2 (en) | 2006-05-17 | 2007-08-01 | Ophthalmic injection method |
| US11/832,301US7887521B2 (en) | 2006-05-17 | 2007-08-01 | Ophthalmic injection system |
| US11/832,243US7871399B2 (en) | 2006-05-17 | 2007-08-01 | Disposable ophthalmic injection device |
| US11/832,364US20070270744A1 (en) | 2006-05-17 | 2007-08-01 | Limited Reuse Assembly For Ophthalmic Injection Device |
| US11/833,471US20080021412A1 (en) | 2006-05-17 | 2007-08-03 | Plunger Linkage and Seal For Ophthalmic Medical Device |
| US11/833,518US20080021419A1 (en) | 2006-05-17 | 2007-08-03 | Plunger Linkage Method For Ophthalmic Medical Device |
| US11/833,668US7887517B2 (en) | 2006-05-17 | 2007-08-03 | Drug casting |
| PCT/US2007/080505WO2008105954A2 (en) | 2006-05-17 | 2007-10-05 | Disposable ophthalmic injection device |
| PCT/US2007/080673WO2008105956A2 (en) | 2006-05-17 | 2007-10-08 | Ophthalmic injection method |
| US12/443,898US8118790B2 (en) | 2006-05-17 | 2007-10-09 | Battery operated surgical hand piece with disposable end |
| US12/109,079US20080197035A1 (en) | 2006-05-17 | 2008-04-24 | Sharps Container System for Two Piece Injection Device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/435,906US20070270750A1 (en) | 2006-05-17 | 2006-05-17 | Drug delivery device |
Related Child Applications (15)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US58162906AContinuation-In-Part | 2006-05-17 | 2006-10-16 | |
| US92149706PContinuation-In-Part | 2006-05-17 | 2006-10-16 | |
| US11/688,573Continuation-In-PartUS7811252B2 (en) | 2006-05-17 | 2007-03-20 | Dosage control device |
| US11/752,064Continuation-In-PartUS7862540B2 (en) | 2006-05-17 | 2007-05-22 | Ophthalmic injection device using shape memory alloy |
| US11/762,844Continuation-In-PartUS7762981B2 (en) | 2006-05-17 | 2007-06-14 | Temperature release mechanism for injection device |
| US11/777,408Continuation-In-PartUS8821440B2 (en) | 2006-05-17 | 2007-07-13 | Dual thermal coefficient dispensing chamber |
| US11/832,364Continuation-In-PartUS20070270744A1 (en) | 2006-05-17 | 2007-08-01 | Limited Reuse Assembly For Ophthalmic Injection Device |
| US11/832,333Continuation-In-PartUS7815603B2 (en) | 2006-05-17 | 2007-08-01 | Ophthalmic injection method |
| US11/832,301Continuation-In-PartUS7887521B2 (en) | 2006-05-17 | 2007-08-01 | Ophthalmic injection system |
| US11/832,243Continuation-In-PartUS7871399B2 (en) | 2006-05-17 | 2007-08-01 | Disposable ophthalmic injection device |
| US11/833,518Continuation-In-PartUS20080021419A1 (en) | 2006-05-17 | 2007-08-03 | Plunger Linkage Method For Ophthalmic Medical Device |
| US11/833,668Continuation-In-PartUS7887517B2 (en) | 2006-05-17 | 2007-08-03 | Drug casting |
| US11/833,471Continuation-In-PartUS20080021412A1 (en) | 2006-05-17 | 2007-08-03 | Plunger Linkage and Seal For Ophthalmic Medical Device |
| US12/443,898Continuation-In-PartUS8118790B2 (en) | 2006-05-17 | 2007-10-09 | Battery operated surgical hand piece with disposable end |
| US12/109,079Continuation-In-PartUS20080197035A1 (en) | 2006-05-17 | 2008-04-24 | Sharps Container System for Two Piece Injection Device |
Publications (1)
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| US20070270750A1true US20070270750A1 (en) | 2007-11-22 |
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| US11/435,906AbandonedUS20070270750A1 (en) | 2006-05-17 | 2006-05-17 | Drug delivery device |
| US11/762,844Expired - Fee RelatedUS7762981B2 (en) | 2006-05-17 | 2007-06-14 | Temperature release mechanism for injection device |
| US11/777,408Expired - Fee RelatedUS8821440B2 (en) | 2006-05-17 | 2007-07-13 | Dual thermal coefficient dispensing chamber |
| US11/833,518AbandonedUS20080021419A1 (en) | 2006-05-17 | 2007-08-03 | Plunger Linkage Method For Ophthalmic Medical Device |
| US11/833,471AbandonedUS20080021412A1 (en) | 2006-05-17 | 2007-08-03 | Plunger Linkage and Seal For Ophthalmic Medical Device |
| US11/833,668Expired - Fee RelatedUS7887517B2 (en) | 2006-05-17 | 2007-08-03 | Drug casting |
| US12/109,079AbandonedUS20080197035A1 (en) | 2006-05-17 | 2008-04-24 | Sharps Container System for Two Piece Injection Device |
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| US11/762,844Expired - Fee RelatedUS7762981B2 (en) | 2006-05-17 | 2007-06-14 | Temperature release mechanism for injection device |
| US11/777,408Expired - Fee RelatedUS8821440B2 (en) | 2006-05-17 | 2007-07-13 | Dual thermal coefficient dispensing chamber |
| US11/833,518AbandonedUS20080021419A1 (en) | 2006-05-17 | 2007-08-03 | Plunger Linkage Method For Ophthalmic Medical Device |
| US11/833,471AbandonedUS20080021412A1 (en) | 2006-05-17 | 2007-08-03 | Plunger Linkage and Seal For Ophthalmic Medical Device |
| US11/833,668Expired - Fee RelatedUS7887517B2 (en) | 2006-05-17 | 2007-08-03 | Drug casting |
| US12/109,079AbandonedUS20080197035A1 (en) | 2006-05-17 | 2008-04-24 | Sharps Container System for Two Piece Injection Device |
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| US9486581B2 (en) | 2002-09-11 | 2016-11-08 | Becton, Dickinson And Company | Injector device with force lock-out and injection rate limiting mechanisms |
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| US8372036B2 (en) | 2009-05-06 | 2013-02-12 | Alcon Research, Ltd. | Multi-layer heat assembly for a drug delivery device |
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| US20130053816A1 (en)* | 2011-07-25 | 2013-02-28 | Tandem Diabetes Care, Inc. | Multi-reservoir infusion pump systems and methods |
| US9750871B2 (en) | 2012-05-17 | 2017-09-05 | Tandem Diabetes Care, Inc. | Pump device with multiple medicament reservoirs |
| US10258736B2 (en) | 2012-05-17 | 2019-04-16 | Tandem Diabetes Care, Inc. | Systems including vial adapter for fluid transfer |
| US9962486B2 (en) | 2013-03-14 | 2018-05-08 | Tandem Diabetes Care, Inc. | System and method for detecting occlusions in an infusion pump |
| US11147916B2 (en) | 2015-08-20 | 2021-10-19 | Tandem Diabetes Care, Inc. | Drive mechanism for infusion pump |
| US12268839B2 (en) | 2015-08-20 | 2025-04-08 | Tandem Diabetes Care, Inc | Drive mechanism for infusion pump |
| US10182939B2 (en) | 2015-09-16 | 2019-01-22 | Novartis Ag | Hydraulic injector and methods for intra-ocular lens insertion |
| US20180140461A1 (en)* | 2016-03-14 | 2018-05-24 | Virchow Biotech Pvt. Ltd. | Sterile protective cover comprising a device for opthalmic delivery |
| US10946141B2 (en)* | 2016-03-14 | 2021-03-16 | Virchow Biotech Pvt. Ltd. | Sterile protective cover comprising a device for opthalmic delivery |
| US11458246B2 (en) | 2018-02-05 | 2022-10-04 | Tandem Diabetes Care, Inc. | Methods and systems for detecting infusion pump conditions |
| US12296141B2 (en) | 2018-02-05 | 2025-05-13 | Tandem Diabetes Care, Inc | Methods and systems for detecting infusion pump conditions |
| CN111956905A (en)* | 2020-07-23 | 2020-11-20 | 中国人民解放军空军军医大学 | Local injection device for hypertrophic scar |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2007307376A (en) | 2007-11-29 |
| US20080097311A1 (en) | 2008-04-24 |
| TW200744558A (en) | 2007-12-16 |
| AU2007202216A1 (en) | 2007-12-06 |
| KR20070111394A (en) | 2007-11-21 |
| BRPI0702340A (en) | 2008-01-15 |
| US20080021412A1 (en) | 2008-01-24 |
| AR061002A1 (en) | 2008-07-30 |
| MX2007005846A (en) | 2008-12-01 |
| IL183295A0 (en) | 2007-12-03 |
| US7762981B2 (en) | 2010-07-27 |
| US20080021413A1 (en) | 2008-01-24 |
| US7887517B2 (en) | 2011-02-15 |
| CN101073682A (en) | 2007-11-21 |
| US20080021419A1 (en) | 2008-01-24 |
| US8821440B2 (en) | 2014-09-02 |
| US20080015545A1 (en) | 2008-01-17 |
| EP1857130A1 (en) | 2007-11-21 |
| US20080197035A1 (en) | 2008-08-21 |
| CA2588519A1 (en) | 2007-11-17 |
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