US20060030881A1 - Ventricular partitioning device - Google Patents

Abstract

This invention is directed to a partitioning device for separating a patient's heart chamber into a productive portion and a non-productive portion. The device is particularly suitable for treating patients with congestive heart failure. The partitioning device has a frame-reinforced, expandable membrane which separates the productive and non-productive portions of the heart chamber. The proximal ends of the ribs of the frame have tissue penetrating elements about the periphery thereof which are configured to penetrate tissue lining the heart wall at an angle approximately perpendicular to a longitudinal axis of the partitioning device. The partitioning device has a hub with a non-traumatic distal end to engage the ventricular wall.

Description

FIELD OF THE INVENTION
• The present invention relates generally to the field of treating congestive heart failure and more specifically, to a device and method for partitioning a patient's heart chamber and a system for delivering the treatment device.
BACKGROUND OF THE INVENTION
• Congestive heart failure (CHF) is characterized by a progressive enlargement of the heart, particularly the left ventricle and is a major cause of death and disability in the United States. Approximately 500,000 cases occur annually in the U.S. alone. As the patient's heart enlarges, it cannot efficiently pump blood forward with each heart beat. In time, the heart becomes so enlarged the heart cannot adequately supply blood to the body. Even in healthy hearts only a certain percentage of the blood in a patient's left ventricle is pumped out or ejected from the chamber during each stroke of the heart. The pumped percentage, commonly referred to as the “ejection fraction”, is typically about sixty percent for a healthy heart. A patient with congestive heart failure can have an ejection fraction of less than 40% and sometimes lower. As a result of the low ejection fraction, a patient with congestive heart failure is fatigued, unable to perform even simple tasks requiring exertion and experiences pain and discomfort. Further, as the heart enlarges, the internal heart valves such as the mitral valve, cannot adequately close. An incompetent mitral valve allows regurgitation of blood from the left ventricle back into the left atrium, further reducing the heart's ability to pump blood forewardly.
• Congestive heart failure can result from a variety of conditions, including viral infections, incompetent heart valves (e.g. mitral valve), ischemic conditions in the heart wall or a combination of these conditions. Prolonged ischemia and occlusion of coronary arteries can result in myocardial tissue in the ventricular wall dying and becoming scar tissue. Once the myocardial tissue dies, it is less contractile (sometimes non-contractile) and no longer contributes to the pumping action of the heart. It is referred to as hypokinetic. As the disease progresses, a local area of compromised myocardium may bulge out during the heart contractions, further decreasing the heart's ability to pump blood and further reducing the ejection fraction. In this instance, the heart wall is referred to as dyskinetic or akinetic. The dyskinetic region of the heart wall may stretch and eventually form an aneurysmic bulge.
• Patients suffering from congestive heart failure are commonly grouped into four classes, Classes I, II, III and IV. In the early stages, Classes I and II, drug therapy is presently the most commonly prescribed treatment. Drug therapy typically treats the symptoms of the disease and may slow the progression of the disease, but it can not cure the disease. Presently, the only permanent treatment for congestive heart disease is heart transplantation, but heart transplant procedures are very risky, extremely invasive and expensive and are performed on a small percentage of patients. Many patient's do not qualify for heart transplant for failure to meet any one of a number of qualifying criteria, and, furthermore, there are not enough hearts available for transplant to meet the needs of CHF patients who do qualify.
• Substantial effort has been made to find alternative treatments for congestive heart disease. For example, surgical procedures have been developed to dissect and remove weakened portions of the ventricular wall in order to reduce heart volume. This procedure is highly invasive, risky and expensive and is commonly only done in conjunction with other procedures (such as heart valve replacement or coronary artery by-pass graft). Additionally, the surgical treatment is usually limited to Class IV patients and, accordingly, is not an option for patients facing ineffective drug treatment prior to Class IV. Finally, if the procedure fails, emergency heart transplant is the only presently available option.
• Other efforts to treat CHF include the use of an elastic support, such as an artificial elastic sock placed around the heart to prevent further deleterious remodeling.
• Additionally, mechanical assist devices have been developed as intermediate procedures for treating congestive heart disease. Such devices include left ventricular assist devices and total artificial hearts. A left ventricular assist device includes a mechanical pump for increasing blood flow from the left ventricle into the aorta. Total artificial heart devices, such as the Jarvik heart, are usually used only as temporary measures while a patient awaits a donor heart for transplant.
• Recently, improvements have been made in treating patient's with CHF by implanting pacing leads in both sides of the heart in order to coordinate the contraction of both ventricles of the heart. This technique has been shown to improve hemodynamic performance and can result in increased ejection fraction from the right ventricle to the patient's lungs and the ejection fraction from the left ventricle to the patient's aorta. While this procedure has been found to be successful in providing some relief from CHF symtoms and slowed the progression of the disease, it has not been able to stop the disease.
SUMMARY OF THE INVENTION
• The present invention is directed to a ventricular partitioning device and method of employing the device in the treatment of a patient with congestive heart failure (CHF). Specifically, the device partitions a chamber of the patient's heart into a main productive portion and a secondary non-productive portion. This partitioning reduces the total volume of the heart chamber, reduces the stress applied to the heart and, as a result, improves the ejection fraction thereof.
• A partitioning device embodying features of the invention has a reinforced partitioning component with a concave, pressure receiving surface which defines in part the main productive portion of the partitioned heart chamber when secured within the patient's heart chamber.
• The reinforced partitioning component preferably includes a hub and a membrane forming the pressure receiving surface. The partitioning component is reinforced by a radially expandable frame component formed of a plurality of ribs.
• The ribs of the expandable frame have distal ends secured to the central hub and free proximal ends. The distal ends are preferably secured to the central hub to facilitate radial self expansion of the free proximal ends of the ribs away from a centerline axis. The distal ends of the ribs may be pivotally mounted to the hub and biased outwardly or fixed to the hub and formed of material such as superelastic NiTi alloy which allows for compressing the free proximal ends of the ribs toward a centerline axis into a contracted configuration and when released allow for their self expansion to an expanded configuration.
• The free proximal ends of the ribs are configured to engage and preferably penetrate the tissue lining the heart chamber to be partitioned so as to secure the peripheral edge of the partitioning component to the heart wall and fix the partitioning component within the chamber so as to partition the chamber in a desired manner. The tissue penetrating proximal tips are configured to penetrate the tissue lining at an angle approximately perpendicular to a center line axis of the partitioning device. The tissue penetrating proximal tips of the ribs may be provided with barbs, hooks and the like which prevent withdrawal from the tips from the heart wall.
• The ribs in their expanded configuration angle outwardly from the hub and the free proximal ends curve outwardly so that the membrane secured to the ribs of the expanded frame forms a trumpet-shaped, pressure receiving surface.
• The partitioning membrane in the expanded configuration has radial dimensions from about 10 to about 160 mm, preferably about 50 to about 100 mm, as measured from the center line axis.
• The partitioning device may be delivered percutaneously or intraoperatively. One particularly suitable delivery catheter has an elongated shaft, a releasable securing device on the distal end of the shaft for holding the partitioning device on the distal end and an expandable member such as an inflatable balloon on a distal portion of the shaft proximal to the distal end to press the interior of the recess formed by the pressure receiving surface to ensure that the tissue penetrating tips or elements on the periphery of the partitioning device penetrate sufficiently into the heart wall to hold the partitioning device in a desired position to effectively partition the heart chamber.
• The partitioning device embodying features of the invention is relatively easy to install and it substantially improves the pumping action of the heart and provides an increase in the ejection fraction of the patient's heart chamber. These and other advantages of the invention will become more apparent from the following detailed description of the invention and the accompanying exemplary drawings.
BRIEF DESCRIPTION OF THE DRAWINGS
• FIG. 1 is an elevational view of a partitioning device embodying features of the invention in an expanded configuration.
• FIG. 2 is a plan view of the partitioning device shown inFIG. 1.
• FIG. 3 is a partial longitudinal cross-sectional view of the hub of the partitioning device shown inFIG. 1.
• FIG. 4 is a transverse cross sectional view of the hub shown inFIG. 3 taken along the lines4-4.
• FIG. 5 is a schematic elevational view of a delivery system for the partitioning device shown inFIGS. 1 and 2.
• FIG. 6 is a transverse cross-sectional view of the delivery system shown inFIG. 5 taken along the lines6-6.
• FIG. 7 is an elevational view, partially in section, of the hub shown inFIG. 3 secured to the helical coil of the delivery system shown inFIG. 5.
• FIGS. 8A-8E are schematic views of a patient's left ventricular chamber illustrating the deployment of the partitioning device shown inFIGS. 1 and 2 with the delivery system shown inFIG. 5 to partition the heart chamber into a primary productive portion and a secondary, non-productive portion.
• FIG. 9 is a partial schematic view of the expandable frame of the partitioning device shown inFIGS. 1 and 2 in an unrestricted configuration.
• FIG. 10 is a top view of the expandable frame shown inFIG. 9.
• FIGS. 11-13 are schematic illustrations of a method of forming the partitioning device shown inFIGS. 1 and 2 from the expandable frame shown inFIGS. 9 and 10.
DETAILED DESCRIPTION OF EMBODIMENTS OF THE INVENTION
• FIGS. 1-4 illustrate apartitioning component10 which embodies features of the invention and which includes apartitioning membrane11, ahub12, preferably centrally located on the partitioning device, and a radially expandable reinforcingframe13 formed of a plurality ofribs14. Preferably, thepartitioning membrane11 is secured to the proximal or pressure side of theframe13 as shown inFIG. 1. Theribs14 have distal ends15 which are secured to thehub12 and free proximal ends16 which are configured to curve or flare away from acenter line axis17. Radial expansion of the free proximal ends16 unfurls themembrane11 secured to theframe13 so that the membrane presents a relatively smooth,pressure receiving surface18 which defines in part the productive portion of the patient's partitioned heart chamber.
• As shown in more detail inFIGS. 3 and 4, the distal ends15 of theribs14 are secured within thehub12 and a transversely disposedconnector bar20 is secured within the hub which is configured to secure thehub12 and thus thepartitioning component10 to a delivery system such as shown inFIG. 5 and6. The curved free proximal ends16 ofribs14 are provided withsharp tip elements21 which are configured to hold theframe13 and themembrane11 secured thereto in a deployed position within the patient's heart chamber. Preferably, thesharp tip elements21 of theframe13 penetrate into tissue of the patient's heart wall in order to secure thepartitioning component10 within the heart chamber so as to partition the ventricular chamber into a productive portion and a non-productive portion.
• Theconnector bar20 of thehub12, as will be described later, allows thepartitioning device10 to be secured to a delivery system delivery and to be released from the delivery system within the patient's heart chamber. The distal ends15 of the reinforcingribs14 are secured within thehub12 in a suitable manner or they may be secured to the surface defining the inner lumen or they may be disposed within channels or bores in the wall of thehub12. Theribs14 are preshaped so that when not constrained other than by themembrane11 secured thereto (as shown inFIGS. 1 and 2), the free proximal ends16 thereof expand to a desired angular displacement away from acenter line axis17 which is about 20° to about 90°, preferably about 50° to about 80°.
• FIGS. 5-7 illustrate asuitable delivery system30 delivering thepartitioning component10 shown inFIGS. 1 and 2 into a patient's heart chamber and deploying thepartitioning component10 to partition the heart chamber as shown inFIGS. 8A-8E. Thedelivery system30 includes aguide catheter31 and adelivery catheter32.
• The guide catheter has aninner lumen33 extending between theproximal end34 anddistal end35. A hemostatic valve (not shown) may be provided at theproximal end34 of theguide catheter31. Aflush port36 on theproximal end34 ofguide catheter31 is in fluid communication with theinner lumen33.
• Thedelivery catheter32 has anouter shaft40 with aninner lumen41 and aproximal injection port42, aninner shaft43 disposed within theinner lumen41 with afirst lumen44 and asecond lumen45.Balloon inflation port46 is in fluid communication with thefirst lumen44 andflush port47 is in fluid communication with thesecond lumen45.Torque shaft48 is rotatably disposed within thesecond lumen44 of theinner shaft43 and has aninjection port49 provided at itsproximal end50 in fluid communication with theinner lumen51 of the torque shaft. Thetorque shaft48 is preferably formed at least in part of a hypotube formed of suitable material such as superelastic NITINOL or stainless steel. Atorque knob52 is secured to theproximal end50 oftorque shaft48 distal to theinjection port49. Ahelical coil screw53 is secured to the distal end54 of thetorque shaft48 and rotation of thetorque knob52 on theproximal end50 of thetorque shaft48 rotates thescrew53 on the distal end54 oftorque shaft48 to facilitate deployment of apartitioning device10. Ainflatable balloon55 is sealingly secured to the distal end of theinner shaft43 and has an interior56 in fluid communication with thefirst lumen44. Inflation fluid may be delivered to the interior56 throughport44ain the portion of theinner shaft43 extending through theballoon55. Inflation of theballoon55 by inflation fluid throughport57 facilitates securing thepartitioning component10.
• To deliver thepartitioning component10, it is secured to the distal end of thedelivery catheter32 by means of thehelical coil screw53. Thepartitioning component10 is collapsed to a first, delivery configuration which has small enough transverse dimensions to be slidably advanced through theinner lumen33 of theguide catheter31. Preferably, theguide catheter31 has been previously percutaneously introduced and advanced through the patient's vasculature, such as the femoral artery, in a conventional manner to the desired heart chamber. Thedelivery catheter32 with thepartitioning component10 attached is advanced through theinner lumen33 of theguide catheter31 until thepartitioning component10 is ready for deployment from the distal end of theguide catheter31 into the patient'sheart chamber58 to be partitioned.
• Thepartitioning component10 mounted on thescrew53 is urged partially out of theinner lumen33 of theguide catheter31 until thehub12 engages the heart wall as shown inFIG. 8B with the free proximal ends16 of theribs14 in a contracted configuration within the guide catheter. The guidingcatheter31 is withdrawn while thedelivery catheter32 is held in place until the proximal ends16 of theribs14 exit thedistal end35 of the guiding catheter. The free proximal ends16 ofribs14 expand outwardly to press the sharpproximal tips21 of theribs14 against and preferably into the tissue lining the heart chamber. This is shown inFIG. 8C.
• With the partitioning component deployed within the heart chamber and preferably partially secured therein, inflation fluid is introduced through theinflation port46 intofirst lumen44 ofinner shaft43 of thedelivery catheter32 where it is directed throughport44ainto theballoon interior56 to inflate the balloon. The inflated balloon presses against thepressure receiving surface18 of thepartitioning component10 to ensure that the sharpproximal tips21 are pressed well into the tissue lining the heart chamber.
• With thepartitioning device10 properly positioned within the heart chamber, theknob52 on thetorque shaft48 is rotated counter-clockwise to disengage thehelical coil screw53 of thedelivery catheter32 from thehub12. The counter-clockwise rotation of thetorque shaft48 rotates thehelical coil screw53 which rides on theconnector bar20 secured within thehub12. Once thehelical coil screw53 disengages theconnector bar20, thedelivery system30, including theguide catheter31 and thedelivery catheter32, may then be removed from the patient.
• The proximal end of theguide catheter31 is provided with anflush port36 to inject therapeutic or diagnostic fluids through theinner lumen33. Similarly, the proximal end of thedelivery catheter32 is provided with aflush port42 in communication withinner lumen41 for essentially the same purpose. Aninflation port46 is provided on the proximal portion of the delivery catheter for delivery of inflation fluid through the firstinner lumen44 to the interior56 of theballoon55.Flush port47 is provided in fluid communication with the secondinner lumen45 of theinner shaft43. Aninjection port49 is provided on the proximal end of thetorque shaft48 in fluid communication with theinner lumen51 of the torque shaft for delivery of a variety of fluids.
• Thepartitioning component10 partitions the patient'sheart chamber57 into a main productive oroperational portion58 and a secondary, essentiallynon-productive portion59. Theoperational portion58 is much smaller than theoriginal ventricular chamber57 and provides for an improved ejection fraction. The partitioning increases the ejection fraction and provides an improvement in blood flow. Over time, thenon-productive portion59 fills first with thrombus and subsequently with cellular growth. Bio-resorbable fillers such as polylactic acid, polyglycolic acid, polycaprolactone and copolymers and blends may be employed to initially fill thenon-productive portion59. Fillers may be suitably supplied in a suitable solvent such as DMSO. Other materials which accelerate tissue growth or thrombus may be deployed in thenon-productive portion59.
• FIGS. 9 and 10 illustrate the reinforcingframe13 in an unstressed configuration and includes theribs14 and thehub12. Theribs14 have a length L of about 1 to about 8 cm, preferably, about 1.5 to about 4 cm for most left ventricle deployments. The proximal ends16 have a flared construction. To assist in properly locating the device during advancement and placement thereof into a patient's heart chamber, parts, e.g. the distal extremity, of one or more of the ribs and/or the hub may be provided with markers at desirable locations that provide enhanced visualization by eye, by ultrasound, by X-ray, or other imaging or visualization means. Radiopaque markers may be made with, for example, stainless steel, platinum, gold, iridium, tantalum, tungsten, silver, rhodium, nickel, bismuth, other radiopaque metals, alloys and oxides of these metals.
• Thepartitioning device10 is conveniently formed by placing athermoplastic tube60, e.g. polyethylene, over theribs14 of theframe13 as shown inFIG. 11 until the proximal ends16 of theribs14 extend out the ends of the thermoplastic tubes as shown inFIG. 12. A first expandedPTFE sheet61 of appropriate size is placed in thefemale platen62 of thepress63. Theframe13 withtubes60 slidably disposed over theribs14 is placed inplaten62 on top of theePTFE sheet61. The center portion of thesheet61 may be provided with an opening through which thehub12 extends. Asecond ePTFE sheet64 is placed on top of theribs14 offrame13 as shown in FIG.13. Themale platen65 is heated, preferably to about 500° F., so that thethermoplastic tubes60 disposed over theribs14 fuse into the porous matrix of theePTFE sheets61 and64. The fused thermoplastic material solidifies and secures thesheets61 and64 to theribs14 and prevents their delamination during use.
• While porous ePTFE material is preferred, themembrane11 may be formed of suitable biocompatitble polymeric material which include Nylon, PET (polyethylene terephthalate) and polyesters such as Hytrel. Themembrane11 is preferably foraminous in nature to facilitate tissue ingrowth after deployment within the patient's heart. Thedelivery catheter32 and the guidingcatheter31 may be formed of suitable high strength polymeric material such as PEEK (polyetheretherketone), polycarbonate, PET, Nylon, and the like. Braided composite shafts may also be employed.
• To the extent not otherwise described herein, the various components of the partitioning device and delivery system may be formed of conventional materials and in a conventional manner as will be appreciated by those skilled in the art.
• While particular forms of the invention have been illustrated and described herein, it will be apparent that various modifications and improvements can be made to the invention. Moreover, individual features of embodiments of the invention may be shown in some drawings and not in others, but those skilled in the art will recognize that individual features of one embodiment of the invention can be combined with any or all the features of another embodiment. Accordingly, it is not intended that the invention be limited to the specific embodiments illustrated. It is intended that this invention to be defined by the scope of the appended claims as broadly as the prior art will permit.
• Terms such a “element”, “member”, “device”, “section”, “portion”, “step”, “means” and words of similar import, when used herein shall not be construed as invoking the provisions of 35 U.S.C. §112(6) unless the following claims expressly use the terms “means” followed by a particular function without specific structure or “step” followed by a particular function without specific action. Accordingly, it is not intended that the invention be limited, except as by the appended claims. All patents and patent applications referred to above are hereby incorporated by reference in their entirety.

Claims (54)

1. A device for treating a patient with congestive heart failure by partitioning a chamber of the patient's heart into a primary productive portion and a secondary non-productive portion, comprising:

a. a partitioning component which has an expandable frame formed of a plurality of ribs having distal ends secured to a central hub and free outwardly flared proximal ends and which has a proximal, pressure receiving face forming a recess in an expanded, deployed configuration defining in part the primary productive portion of the patient's heart chamber to be partitioned; and

b. a plurality of tissue penetrating securing elements disposed at free ends of the ribs configured to penetrate tissue lining the heart chamber at an angle essentially perpendicular to the center line axis of the partitioning device to secure the periphery of the partitioning device to the heart chamber.

2. The device ofclaim 1 wherein reinforced partitioning component has a contracted configuration for delivery to patient's heart chamber to be partitioned.

3. The device ofclaim 1 wherein the pressure receiving surface of the partitioning component is formed at least in part of a membrane.

4. The device ofclaim 3 wherein the membrane is foraminous.

5. The device ofclaim 3 wherein the membrane is formed at least in part of a polymeric fabric.

6. The device ofclaim 5 wherein the polymeric fabric of the membrane is secured to the ribs by polymeric material fused in the polymeric fabric.

7. The device ofclaim 6 wherein the distal ends of the ribs are configured to facilitate abduction of the free proximal ends of the ribs away from a centerline axis to facilitate expansion of the reinforced partitioning component.

8. The device ofclaim 6 wherein the free proximal ends of the ribs are outwardly curved.

9. The device ofclaim 8 wherein the free proximal ends of the ribs have tips which penetrate the tissue lining the heart chamber at an angle of not more than 30° away from a line perpendicular to the center line axis of the partitioning device.

10. The device ofclaim 1 wherein the pressure receiving surface has radial dimensions from a center line axis of about 10 to about 160 mm.

11. The device ofclaim 1 wherein the pressure receiving surface has radial dimensions from a center line axis of about 5 to about 80 mm.

12. The device ofclaim 1 wherein the frame has about 3 to about 30 ribs.

13. The device ofclaim 1 wherein the frame has about 6 to about 16 ribs.

14. The device ofclaim 1 wherein the expandable frame is self expanding.

15. The device ofclaim 1 wherein the frame is formed of superelastic NiTi, alloy which is in an austenite phase when unstressed.

16. The device ofclaim 1 wherein the frame is in a stress maintained martensite phase when delivered through the patient's vasculature to the patient's heart chamber.

17. The device ofclaim 3 wherein the membrane is formed at least in part of expanded fluoropolymer.

18. The device ofclaim 17 wherein the expanded fluoropolymer is polytetrafluoroethylene.

19. A partitioning apparatus for a patients heart chamber to Improve cardiac ejection fraction, comprising:

a. a central hub component;

b. an expandable frame component having a plurality of ribs with free, outwardly flared proximal ends and distal ends secured to the central hub component;

c. a membrane component secured to the expandable frame ribs which defines a recessed, pressure receiving surface; and

d. tissue penetrating tips on a plurality of free, outwardly flared proximal ends which are configured to penetrate tissue lining the heart chamber to be partitioned at an angle essentially perpendicular to a center line axis of the partitioning device.

20. The partitioning apparatus ofclaim 30 wherein the hub has a non-traumatic distal tip to engage the region of the patients ventricular wall.

21. The partitioning apparatus ofclaim 30 wherein the non-traumatic distal tip has a bullet shape.

22. The partitioning apparatus ofclaim 30 wherein the membrane component is secured to the proximal side of the ribs.

23. The partitioning apparatus ofclaim 30 wherein the membrane component is secured to the distal side of the ribs.

24. An intracorporeal delivery catheter for a ventricular partitioning device for treating a patient with CHF, comprising:

a. an elongated shaft which has proximal and distal ends, a port proximal to the distal end and an inner lumen In fluid communication with the port;

b. a releasable securing element on the distal end of the elongated shaft configured to secure and release a ventricular partitioning device; and

c. an inflatable member on a distal portion of the elongated shaft having an interior in fluid communication with the inner lumen in the elongated shaft through the port therein which Is configured to expand a reinforced membrane of the partitioning device.

25. The intracorporeal delivery catheter ofclaim 24 wherein the elongated shaft has an outer shaft member with an inner lumen and an inner shaft member disposed within the inner lumen of the outer shaft, which has proximal and distal end, which has a first inner lumen extending within the inner shaft to the port proximal to the distal end of the inner shaft member to provide inflation fluid to the interior of the inflatable member, which has a second port in the distal end thereof and a second inner lumen extending within the inner shaft to the port in the distal end thereof.

26. The intracorporeal delivery catheter ofclaim 25 including a torque shaft which has proximal and distal ends, which is rotatably disposed within the second inner lumen of the inner shaft member and which has the releasable securing element on the distal end thereof for securing and releasing a ventricular partitioning device.

27. The intracorporeal delivery catheter ofclaim 26 wherein the releasable securing element on the distal end of the torque shaft is a helical screw connection element.

28. The intracorporeal delivery catheter ofclaim 27 wherein the helical screw connection element on the distal end of the torque shaft is configured to engage a connector bar on the partitioning device.

29. An intracorporeal delivery catheter for a ventricular partitioning device for treating a patient with CHF, comprising:

a. an elongated outer shaft with an inner lumen;

b. an inner shaft which is disposed within the inner lumen of the outer shaft, which has a first inner lumen extending within the inner shaft to a port proximal to the distal end thereof, which has a second inner lumen extending within the inner shaft to the distal end thereof; a balloon mounted on a distal portion of the inner shaft having an interior in fluid communication with the first inner lumen through the port;

c. a torque shaft which has proximal and distal ends, which is rotatably disposed within the second inner lumen of the inner shaft, which has a screw connection element on the distal end thereof extending out of the distal end of the inner shaft and configured to receive a partitioning device; and

d. an inflation port in fluid communication with the first inner lumen of the inner shaft for delivery of inflation fluid therethrough to the interior of the balloon.

30. An Intracorporeal partitioning component comprising:

a. a frame having a plurality of ribs with radially extending proximal ends and with distal ends secured to a hub; and

b. at least one porous sheet material secured to the ribs of the frame by fused thermoplastic material within the porous sheet material.

31. The intracorporeal partitioning component ofclaim 30 wherein at least one porous sheet is secured to the upper portion of the ribs of the frame and at least one sheet is secured to the lower portion of the ribs of the frame by thermoplastic material within the porous sheets.

32. A method of securing a porous polymeric sheet material to rib components of a frame structure, comprising:

a. sliding a thermoplastic tube over one or more rib components of the frame;

b. applying a porous sheet to the ribs covered with the thermoplastic polymeric tubes to form an assembly; and

c. heating the assembly to fuse the polymeric material of the thermoplastic tubes within the porous sheet.

33. The method ofclaim 32 wherein a porous sheet is applied to the upper surface of the frame.

34. The method ofclaim 32 wherein a porous sheet is applied to the lower surface of the frame.

35. The method ofclaim 32 wherein a first porous sheet is applied to the upper surface of the frame and a second porous sheet is applied to the lower surface of the frame.

36. The method ofclaim 35 wherein the assembly is placed onto a receiving platen of a press and a hot pressing platen is pressed against the assembly to fuse the thermoplastic polymeric material on the ribs of the frame within one or both of the porous membranes.

37. A method of treating a patient with congestive heart failure by partitioning the patient's heart chamber, comprising:

a. providing a reinforced membrane having a first contracted configuration for delivery to the patient's heart chamber and a second expanded configuration for deployment within the patient's heart chamber;

b. advancing the reinforced membrane in the first contracted configuration into the chamber of the patient's heart;

c. inflating an inflatable member disposed within the membrane to expand the reinforced membrane to the second expanded configuration to facilitate securing the reinforced membrane within the patient's heart chamber to partition the chamber into a primary productive portion and a secondary non-productive portion.

38. The method ofclaim 37 wherein the reinforced membrane is advanced into the patient's heart chamber through an inner lumen of a delivery catheter.

39. The method ofclaim 38 wherein the inflatable member is positioned on a distal portion of the delivery catheter.

40. The method ofclaim 37 wherein the expanding inflatable member secures a peripheral edge of the reinforced membrane to a wall defining at least in part the patients heart chamber.

41. The method ofclaim 37 wherein a central portion of the expanded reinforced membrane is spaced from a wall defining in part the patients heart chamber.

42. The method ofclaim 38 wherein the reinforced membrane is positioned within an inner lumen of the delivery catheter in the first contracted configuration, and advanced therein to a discharge port in the distal end of the delivery catheter and discharged from the discharge port into the patient's heart chamber where the contracted reinforced membrane expands to the second expanded configuration due at least in part to the expanding inflatable member.

43. The method ofclaim 38 wherein the delivery catheter is percutaneously introduced into the patient's vasculature and advanced therein until the distal end of the delivery catheter is disposed within the patients heart chamber.

44. The method ofclaim 40 wherein the edge of the reinforced membrane is secured to a wall defining at least in part the heart chamber by anchoring elements provided on the edge of the reinforced membrane.

45. The method ofclaim 37 wherein the reinforced membrane is in part self expanding.

46. A method of treating a patient with congestive heart failure, comprising:

a. providing an expandable reinforced membrane having a periphery with a plurality of anchoring elements thereon;

b. advancing the reinforced membrane in a contracted configuration within the patients vasculature until the reinforced member is disposed within a chamber of the patient's heart; and

c. inflating a balloon within the contracted reinforced membranes to expand the reinforced membrane into an expanded configuration within the heart chamber to secure the periphery of the reinforced membrane to the heart wall by the anchoring elements on the periphery of the reinforced membrane.

47. A method of treating a patient with congestive heart failure, comprising the steps of:

a. providing an expandable reinforced membrane having a periphery with a plurality of anchoring elements thereon;

b. advancing the reinforced membrane in a contracted configuration within the patient's vasculature until the reinforced member is disposed within a chamber of the patient's heart; and

c. inflating a balloon within the contracted reinforced membranes to expand the reinforced membrane into an expanded configuration within the heart chamber to secure the periphery of the reinforced membrane to the heart wall by the anchoring elements on the periphery of the reinforced membrane.

48. An intracorporeal product comprising:

a. a first component configured for intracorporeal deployment; and

b. at least one sheet of ePTFE material secured to the first component by fused thermoplastic material therebetween.

49. The intracorporeal product ofclaim 30 wherein a second ePTFE sheet is secured to the first component by thermoplastic material within the porous sheets.

50. A method of making an intracorporeal product securing a porous polymeric sheet material to rib components of a frame structure, comprising:

a. providing a ePTFE sheet;

b. providing an intracorporeal component;

c. deploying a thermoplastic element over at least part of the intracorporeal component;

d. applying the ePTFE sheet to at least a portion of the intracorporeal component covered by the at least one thermoplastic element to form an assembly; and

e. heating the assembly to fuse the thermoplastic material and secure the ePTFE sheet to the intracorporeal component.

51. The method ofclaim 50 wherein the ePTFE sheet is applied to an upper surface of the intracorporeal component.

52. The method ofclaim 50 wherein the ePTFE sheet is applied to a lower surface of the intracorporeal component.

53. The method ofclaim 51 wherein a second ePTFE sheet is applied to the lower surface of the intrecorporeal component.

54. The method ofclaim 50 wherein pressure is applied to the assembly at elevated temperature to fuse the thermoplastic polymeric material and secure the ePTFE sheet to the intracorporeal component.

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