US20050288693A1 - Connector, applicator and method for mechanically connecting hollow structures, in particular small blood vessels - Google Patents

Abstract

The invention relates to a connector, applicator and method for mechanically connecting hollow structures, in particular small blood vessels, in order to make an anastomosis. The connector incorporates various features to create a reliable engagement with the vessel walls to make a good connection thereof. The connector comprises knife members to make an arteriotomy in and punch a hole in one of the vessel walls, comprises an expansion portion to cause a large expansion with a minimum profile, and comprises anvil members to reliably bring the staple-like elements to the joining position.

Description

• This application is a divisional of U.S. patent application Ser. No. 09/708,617, filed on Nov. 9, 2000.
• The present invention relates to a connector and applicator for mechanically connecting hollow structures, in particular small blood vessels, through so called anastomoses. Such means may for example be used when making a bypass past narrowings or occlusions of arteries caused by arteriosclerosis.
• One such connector and applicator are known from WO-A-99/21491 of applicants. This document discloses several embodiments of connectors which are made up of an annular member and circumferentially spaced joining means for holding the vessel walls together in order to make the joint between the vessels. The connectors as disclosed are suitable both for end-to-side and side-to-side anastomoses.
• The object of the present invention is to further improve the connector and applicator for making mechanical connections between hollow structures.
• To obtain this object, the present invention provides a connector for mechanically connecting hollow structures, in particular small vessels, comprising:
• an annular member of deformable material, said member having a center line and being adapted to be permanently deformed by expansion from a first size in a starting position in which it is delivered to a desired anastomoses site, to a second, larger size in a joining position in which it connects the hollow structures, and
• circumferentially spaced means for joining abutting walls of the hollow structures together, said means including staple-like elements being adapted to be permanently deformed from a starting position in which the connector is delivered to a desired site, to a joining position in which they engage the hollow structures to connect them, said staple-like elements having at least two free ends and being attached to the annular member between its free ends and being tapered from the annular member towards their free ends.
• This connector according to the invention has various advantages. The expandability of the annular member is advantageous because, as a result, the size of the connector is small during delivery, whereas the size of the annular member can be adapted to the size of the vessels on the site of the anastomosis. The staple-like elements are very suitable for holding together adjacent vessel walls of the vessels to be connected. Due to the tapering, the predictability of the plastic deformation, which is required to close the staples, is improved. If the staples should be curved according to a certain curvature, the deformation will start at the tips and progress towards the annular member, which leads to a predictable deformation. The tapering can take various forms. The staple-like elements may for example be conically or wedge-shaped towards the free ends. Preferably, the radial thickness of the staple-like elements is diminished towards the respective free ends, but also the width may be tapered.
• In a preferred embodiment, the staple-like elements are substantially straight and parallel to the center line of the annular member. With this arrangement, the connector can have a minimum diameter which facilitates easy handling during an operation. From this straight starting position, the staple-like elements can be deformed either to a C-shape to form a perfect or overlapping circle, or to a B-shape or an overlapping B-shape.
• In order to further increase the predictability of the deformation phase of the staple-like elements, the staple-like elements may be provided with extreme tips which are preformed into the anticipated curve of the deformation to the joining position.
• It is not necessary that the portions of the staple-like elements on either side of the point of attachments to the annular member are mirror shaped. The length, thickness and slope towards the free ends can be varied to accommodate required bending characteristics or vessel wall thicknesses.
• It is preferred to make the connector according to the invention from one piece of material, preferably metal, for example stainless steel 316L or titanium. Connectors which are sufficiently small for use in coronary artery bypass surgery can be manufactured from one piece of metal by using a combination of cutting with a lathe and subsequently using laser techniques or electric erosion techniques. In this way, the connector is made directly in 3D. Alternatively, 2D-techniques like photo-etching and electroplating can be used to make 2D pieces out of thin, flat material. These can be converted into 3D, either by forcing a 2D shape into 3D, or by bending and welding together the beginning and end of the 2D shape.
• An easily expandable annular member is obtained if the annular member is made up from a continuous elongated piece of material having a sinusoidal pattern meandering about a circle line through the annular member. In this case, the staple-like elements are preferably formed at an apex of the sinusoidal pattern.
• In order to increase the maximum size of the annular member in the joining position, it is preferred to have the main plane of the annular member at an angle to the center line of the annular member.
• Due to this feature, the orifice area of the anastomosis can be increased without increasing the size of the connector and applicator, which is limited by the diameter of the hollow structures through which the applicator is inserted. The above feature results in an elliptical anastomosis with an increased orifice area as compared to a circular anastomosis, while the size of the applicator can remain unchanged. In case the main plane of the annular member is at an angle of for example 45°, the area is increased by a factor √2=1.41. Practically the staple-like elements of the connector will remain parallel to the center line of the applicator and connector.
• The present invention also includes an applicator for delivering and deploying a connector for mechanically connecting hollow structures, comprising:
• a shank-like element;
• a head formed at a distal end of the shank-like element, said head being adjustable in such a manner that the annular member and the staple-like elements of the connector are deformed from the starting position to the joining position when said adjusting takes place,
• said head including an inner member and an outer member which are longitudinally slidable and include longitudinally opposite anvil formations which are movable to and for upon relative sliding movements of the inner and outer members in order to deform the staple-like elements to their joining position;
• wherein both the inner and outer members are expandable to deform the connector to the joining position.
• Due to the expandability of both the inner and outer members, it is possible to minimize the radial dimensions of the applicator. It is now possible to make the head of the applicator smaller than the radial size of the connector in the joining position, since the outer member of the head of the applicator is enabled to expand together with the connector.
• A simple manner to obtain the expandability of the inner and outer members is to slit or cut them in axial direction. Preferably, the outer member includes at least first slits and second slits, said first slits are arranged at an end of the outer member which forms part of the head and extends between the anvil formations, said second slits being spaced from said and of the outer member, and alternate with the first slits and are configured in overlapping arrangement.
• Due to this configuration of the slits or cuts, the radial as well as the tangential stiffness of the delicate material between the slits is increased. This further assists in diminishing the dimensions of the head of the applicator.
• Another advantageous feature to minimize the radial dimensions of the head is the feature that the anvil formations, on their sides facing each other, have curved surfaces dictating the deformation of the staple-like elements, said curved surfaces being formed to such an extent that they terminate at an angle to the longitudinal axis of the head which is slightly beyond 90°, for example 91°-120°.
• These “low profile” anvil formations make the applicator head as slender as possible, but nonetheless allow for a predictable bending of the staple-like elements of the connector.
• An alternative applicator according to the invention comprises a shank-like element, and a head formed at a distal end of the shank-like element, said head being adjustable in such a manner that the annular member and the staple-like elements of the connector are deformed from the starting position to the joining position when said adjusting takes place. The head includes an inner member and an outer member which are longitudinally slidable and include longitudinally opposite anvil formations which are movable to and from upon relative sliding movements of the inner and outer members in order to deform the staple-like elements to their joining position. The head further includes an expansion member comprising wedges adapted to slide underneath the annular member.
• In this embodiment of the applicator according to the invention, the expansion of the annular member of the connector is effected by the wedges of the expansion member which slide underneath the annular member and thereby urging the annular member outwardly.
• One way of enabling the wedges to slide underneath the annular member is to make the expansion member slidable relative to the inner and outer members, and in this embodiment it is advantageous if the wedges are interleaved with the anvil formations, since the head of the applicator can then be made as small as possible.
• In this embodiment of the applicator, the simplest design thereof is obtained if the staple-like elements are first deformed to their joining position, whereafter the annular member is expanded by the wedges of the expansion member. In that case it is not necessary to make the outer member expandable and in a preferred embodiment it is even possible to expand the annular member of the connector and remove it from the head of the applicator in distal direction over the anvil formations of the inner member in a continued operation.
• In another embodiment of the applicator according to the invention, the head includes not only an anastomosis portion which is adjustable in such a manner that the annular member and the joining elements of the connector are deformed from the starting position to the joining position when said adjusting takes place, but also a punching portion distally of the anastomosis portion and including two relatively movable parts configured to cause a punching action on a wall of the hollow structure and to catch or trap a punched-out part of said wall.
• With such applicator it is possible to both cut a hole in the vessel wall in order to enable the applicator to enter the vessel, and to perform the anastomosis with the same instrument. This simplifies the procedure and reduces time and cost.
• The invention further includes a method of delivering and deploying a connector for mechanically connecting hollow structures. This method comprises the steps of:
• providing a connector for joining adjacent walls of the hollow structures,
• providing an applicator for said connector, said applicator including cutting means,
• making an arteriotomy in the wall of one of the hollow structures,
• inserting the cutting means of the applicator partly into said one of the hollow structures through the arteriotomy, so as to cut a hole in the wall,
• advancing the applicator up to a desired position,
• deploying the connector by means of the applicator so as to connect the walls of the hollow structures.
• The invention will further be described with reference to the drawings showing embodiments of the invention by way of example.
• FIG. 1 is a perspective view of an embodiment of the connector according to the invention.
• FIG. 2 is a view of the connector ofFIG. 1 in radial direction.
• FIG. 3 is a view of the connector ofFIG. 1 in axial direction.
• FIG. 4 is a perspective view of an applicator for use with the connector ofFIGS. 1-3, on a smaller scale.
• FIG. 5 is a front view of the applicator ofFIG. 4.
• FIG. 6 is a sectional view of the applicator ofFIG. 4, along the plane VI-VI inFIG. 5.
• FIG. 7 is an axial view of the outer member of the applicator ofFIG. 4, on a larger scale.
• FIG. 8 is a sectional view of the outer member ofFIG. 7 along the plane VIII-VIII.
• FIG. 9 is an axial view of the inner member of the applicator ofFIG. 4, on a larger scale.
• FIG. 10 is a sectional view of the inner member ofFIG. 9, taken along the line X-X.
• FIG. 11 is a very schematic perspective view of members forming the head of an alternative embodiment of the applicator according to the invention.
• FIG. 12 is a sectional view along the line XII-XII inFIG. 11.
• FIGS. 13A-13C are longitudinal sectional views of the applicator head ofFIG. 11, in three different positions during deployment of the connector.
• FIG. 14 is a very schematic side view of an alternative embodiment of the connector according to the invention.
• FIG. 15 is a very schematic side view of the head of an applicator for delivering and deploying the connector ofFIG. 14.
• FIG. 16 is a very schematic, partly cut-away side view of the head of a further embodiment of an applicator according to the invention.
• FIGS. 1-3 show an embodiment of a connector for mechanically connecting hollow structures, in particular small blood vessels, such as coronary arteries. The connector is specially designed for making a side-to-side anastomosis but may also be used or adapted to make other connections, for example an end-to-side anastomoses or other joints.
• The connector as shown comprises an annular one and a plurality of joining means in the form of staple-like elements to spaced around the circumference of theannular member1. The annular member and staple-like elements are preferably formed from one piece of material, preferably metal such as stainless steel 316L or titanium.
• The annular member as shown inFIGS. 1-3 comprises a continuous elongated element having a sinusoidal pattern meandering about a circle line through the annular member. The alternatingwaves3 and4 of the pattern have a different wave length in order to accommodate the staple-like elements2 which are formed at eachwave4, at the apex thereof. The meandering pattern of theannular member1 creates the expandability of the annular member by widening the meanders or waves of the pattern thereby increasing the diameter of theannular member1. The deformation of theannular member1 is plastically, so that theannular member1 will retain its shape after expansion.
• The configuration of theannular member1 may vary within a broad range, including the length of theannular member1. The term annular also covers tubular members.
• The staple-like elements2 comprise twostaple portions5,6 which extend from the point of attachment to theannular member1 in opposite directions. In the embodiment shown, bothstaple portions5,6 are aligned and are substantially each other's mirror image, but it should be kept in mind that that need not be the case. Instead thereof, the length, thickness and slope towards the free ends of thestaple portions5,6 can be varied to accommodate required bending characteristics or vessel wall thicknesses.
• As is shown inFIGS. 1-3, in which the connector is shown in its starting position in which it is delivered to the anastomosis site, the staple-like elements are substantially straight and extend parallel to the center axis of the annular member. Thestaple portions5,6 are slightly tapered towards their free ends, both in radial thickness and in circumferential width. The tapering is on the outer side of thestaple portions5,6, whereas the radial inner side of thestaple portions5,6 extends parallel to the center axis. The circumferential sides of thestaple portions5,6 are inclined relative to a radial plane through the center of thestaple portions5,6 such that the width of a staple-like element2 is smaller on the radial inner side than on the radial outer side. If desired, the extreme tips of thestaple portions5,6 may be preformed into the anticipated curve, to increase the predictability of the deformation of thestaple portions5,6. Thewaves3 may also be slightly tapered, i.e. having a diminishing thickness in axial direction in the same manner as theadjacent staple portions5.
• FIGS. 4-10 show an embodiment of the applicator according to the invention. The applicator includes amain body7, agrip8 extending downwardly therefrom on the rear end, acontrol lever9 pivotally connected to the front end of themain body7 and extending downwardly, and astroke limiter10 pivotally attached to the lower end of thecontrol lever9 and slidably connected to the lower end of thegrip8. Apin slot connection11 between thestroke limiter10 and thegrip8 determines the maximum stroke of thecontrol lever10. The control arm may be locked in position by locking thestroke limiter10 to thegrip8. Thecontrol lever9 is pivotally connected to anintermediate pivot12 in order to provide along lever arm13 and ashort lever arm14. The end of theshort lever arm14 is pivotally connected to a slidingblock15, the sliding motion being guided and limited through abolt16.
• Attached to the slidingblock15 is anouter tube member17 and attached to themain body7 is aninner tube member18. The inner andouter members17,18 together form a shank-like element and on the free end thereof ahead20 adapted to accommodate a connector in order to deliver it to the anastomosis site and to deploy it into a joining position.FIGS. 7 and 8/8ashow theouter tube member17 andFIGS. 9 and 10/10ashow theinner tube member18 in more detail. Inside of the inner tube member is an expansion core connected to an expansion control means22.
• Theouter member17 is provided on its distal end with proximal anvil formations oranvils23 having acurved surface24 facing, in a assembled condition, correspondingcurved surfaces25 of distal anvil formations oranvils26 provided on the distal end of theinner member18. The number of distal andproximal anvils23,26 is equal to the number of staple-like elements2 of each connector, in thiscase8. Theanvils23,26 are distributed around the circumference of the inner andouter members17,18 in the same manner as the staple-like elements on the connector, in this case equally spaced around the circumference. Theinner member18 is provided with aseat27, proximal of theanvils26, to accommodate the connector during delivery and in this starting position of the applicator and connector, the inner andouter members17,18 have such relative position that the connector is positioned betweenadjacent anvils23 and26 of the inner andouter members17,18, with each staple-like element2 being aligned withrespective anvils23,26.
• In order to be able to expand the connector which is seated on theseat27 of theinner member18, this inner member is slitted with cuts or slits28 extending from the distal end of the inner member18 a distance in proximal direction. The length of the slits is such that the tongues left between theslits28 may undergo a sufficient radial deflection to expand the connector to a sufficient extent. The length of the slits may for example be 5-10 times the diameter of theinner member18. Thelumen29 through theinner tube member18 has aflaired end part30, in which the diameter of the lumen is increased in distal direction, for example at an angle of approximately 30°. Thisend part30 is adapted to accommodate the tapered end part of theexpansion core21, so that when theexpansion core21 is retracted in proximal direction by the expansion control means22, the tapered end part urges the tongues between theslits28 of theinner tube member18 outwardly so that the connector present on theseat27 is expanded.
• As is shown inFIGS. 7 and 8, also theouter tube member17 is slitted. Theouter tube member18 comprises first slits31 extending from the distal end of the outer tube member17 a distance in proximal direction, and partly overlappingsecond slits32 which alternate with thefirst slits31 and extend from a position intermediate the ends of thefirst slits31 to a position proximal of thefirst slits31. The total length of the first and second slits may for example be 5-10 times the diameter of theouter member18. Due to this slit arrangement, the radial and tangential strength of theouter member17 is increased.
• The operation of the applicator and connector as shown and described before is as follows.
• The shank-like element19 with a connector positioned on theseat27 of thehead20 is inserted into one of the vessels to be joined and is delivered to the site where the anastomosis should be accomplished. Thecontrol lever9 is in the position as shown inFIG. 4. If thehead20 and therefore the connector is positioned correctly with respect to vessel walls which are positioned around the connector, the expansion control means22 is actuated to retract theexpansion core21 so as to expand theinner member18 and therefore theannular member1 of the connector. Since theouter tube member17 is also slitted, it is possible for theouter member17 to follow the expansion of the inner member. As a result theanvil formations23 and26 remain substantially in their relative opposite positions, so that, after expansion of theannular member1 of the connector, it is possible to activate theanvils23,26 in order to deform the staple-like elements2 of the connector.
• The activation of theanvils23,26 is effected by sliding theouter tube member17 in distal direction along theinner member18 so as to bring theopposite anvils23,26 closer to each other thereby engaging the initiallystraight staple portions5,6 of the staple-like elements2 and upon a further approaching movement ofanvils23,26 thestaple portions5,6 follow the curvature of thecurved surfaces24,25 of theanvils23,26. The curved surfaces24,25 are shaped as circular segments, which extend through approximately 91-120°, and preferably 115°, which is sufficient to allow a full deformation of eachstaple portion5,6. Depending on the lateral and radial curvature of thesurfaces24,25,staple portions5,6 are deformed either to a C-shape to form a perfect or overlapping circle, or to a B-shape or an overlapping B-shape. After both theannular member1 and the staple-like elements2 are deformed into their joining position, thestaple portions5,6 clamp the vessel walls of adjacent vessels between each other thereby effecting an anastomosis. Theexpansion core21 can then be moved back to the starting position so that both the inner and outer members are collapsed into their unexpanded condition in which the outer dimensions of thedistal anvil formations26 is smaller than the inner dimension of the anularmember1 of the connector in expanded condition, so that the applicator can be withdrawn from within theannular member1 of the connector so as to be removed from the vessel and the body of the patient.
• FIGS. 11-13 show an alternative embodiment of an applicator according to the invention, which may be used to deliver and deploy the connector ofFIGS. 1-3.FIGS. 11-13 show ahead120 of the shank-like element of the applicator, said head being formed by anouter member117 and aninner member118. The inner member has aseat127 anddistal anvils126. Theouter member17 hasproximal anvils123 between each twoadjacent anvils123. There is created agap133 of sufficient axial length to accommodatewedges134 and provided on the distal end of anexpansion member135. Theexpansion member135 fits slidingly around theouter member117 such that the wedges are positioned in theirrespective gap133 betweenadjacent anvils23 or distally thereof. Thewedges134 extend inwardly from the tube-like expansion member135 up to the outer diameter of theinner member118, so that the extreme tips of thewedges134 engage the outer surface of theinner member118. The extreme tips of thewedges134 are sharp so as to facilitate them to slide underneath theannular member1 so as to engage theannular member1 and upon a distal sliding movement of theexpansion member135 relative to the inner andouter members117,118, theannular member1 of theconnector1 is expanded by thewedges134.
• In this embodiment, the deformation of the staple-like elements2 take place before the expansion of theannular member1, so that the inner andouter members117,118 are actuated first in order to close the staple-like elements2 (FIG. 13a-13b), whereafter theexpansion member135 is moved in distal direction so as to expand theannular member1 and urge it over theanvil formations126 so as to remove the connector from thehead120 of the applicator (FIG. 13c).
• FIG. 14 shows an alternative embodiment of a connector for connecting the walls of hollow structures, in particular small vessels through an anastomosis. The connector includes anannular member201 having staple-like elements202. Theannular member201 and staple-like elements202 are very similar to those of the embodiment ofFIG. 1, with the exception of one aspect. The connector has a center line C which is in the center of the lumen through the connector. The connector also includes a main plane M which extends through the middle of the annular member. In this embodiment, the center line C is at an angle to the main plane M, which is different from 90°. In the present case, the angle within the plane of the drawing is circa 45°. The staple-like elements202 extend parallel to the center line C.
• The reason for using this embodiment is as follows. The maximum size (orifice area) of the anastomosis is limited by the size of the connector and applicator, which in turn is limited by the diameter of the vessel through which the applicator and connector are inserted. In order to increase the orifice area of the anastomosis, the plane of stapling can be tilted, for example 45°. After expansion to the joining position, this results in an elliptical anastomosis with an increased orifice area (in this case √2=1.41) as compared to a circular anastomosis, whereas the size of the applicator remains unchanged. Thus, it is possible to create bigger anastomoses through a blood vessel having a particular size.
• In practice, the staple-like elements202 of the connector will remain parallel to the central axis of the applicator, while the meandering ring will extend at an angle of 45° to a plane which is perpendicular to the center line C.The meandering waves203,204 are, however, within the circular cylinder around the center line C.
• FIG. 15 shows a head220 of an applicator to deliver and deploy the connector according toFIG. 14. As is shown, the position of the proximal anddistal anvil formations223,226 are adapted to the relative position of the staple-like elements202.
• FIG. 16 shows a further embodiment of an applicator for making anastomoses. In anastomosis procedures, it is often desirable to punch out a hole in the vessel wall at the site of the anticipated anastomosis. This is especially the case when doing the proximal anastomosis in CABG (coronary artery bypass grafting) operations, where for example a piece of saphenous vein graft has to be connected to the ascending aorta, which is a big (30 mm) artery and has a significant wall thickness (2-3 mm). However, on a much more delicate scale, punching out a small hole for the distal anastomosis on the coronary artery itself could also prove to be advantageous.
• The embodiment of the applicator according toFIG. 16 has means to punch out a hole in the vessel wall incorporated in the head thereof.FIG. 16 shows that the head of this embodiment includes ananastomosis portion336 and a punchingportion337. This punchingportion337 is positioned distally of theanastomoses portion336. The punchingportion337 includes two relatively movable parts, adistal part338 and aproximal part339. Thedistal part338 is mounted on acore340 running through the head and shank and is adapted to be operated in order to move axially with respect to theproximal part339. On their sides facing each other, bothparts338 and339 are provided with cutting means, including acircular knife341 on theproximal portion339 and acounter edge342. Thecircular knife341 is sized to accurately slide over thedistal part338 while performing a cutting action in cooperation with theedge342. The distal front of thedistal part338 is rounded for easy insertion into an arteriotomy. Alternatively, this rounded front can be replaced by a knife or a conical shape, ending in a sharp point. This configuration permits creating an arteriotomy, punching out a hole and securing the anastomosis with one instrument and requiring only one instrument insertion. To punch the hole this rounded front of thedistal part338 is inserted into the arteriotomy, subsequently thisdistal part338 is pulled against thecircular knife341 of theproximal part339. A circular piece of vessel wall is then cut out and remains trapped between and inside the distal andproximal parts338,339 which together enclose this vessel wall piece. This entrapment is important since loose tissue fragments can embolize.
• Subsequently, the applicator is pushed further inwardly so that theanastomosis portion336 is brought in line with the vessel walls to be joined. The expansion mechanism of theanastomosis portion336 is activated by further retracting thecore340 anddistal part338 in order to push the expansion core321 (formed on the proximal part339) in proximal direction with respect to theanastomosis portion336 so as to expand theseat327 where the connector is positioned. The further operation of the applicator is similar to that of the embodiment ofFIGS. 4-10.
• This embodiment has the unique feature of being capable to punch a hole and secure the anastomosis during one instrument insertion. Because it is not necessary to remove the applicator between these two manipulations, there is very limited blood loss and maximum control. This makes the applicator very suitable for making proximal anastomoses on the aorta in port access CABG.
• Alternatively, the punch mechanism could be replaced by a single, linear knife, which makes a linear arteriotomy. The applicator is than advanced through this arteriotomy and deforms it to a more circular shape.
• From the foregoing it is clear that the present invention provides a connector, applicator and method for mechanically connecting small blood vessels and the like in a simple, reliable and efficient manner.
• The punch mechanism could also be replaced by a simple, circular knife. A pointed wire with a simple retaining mechanism like a hook, extending distally to the circular knife would puncture the vessel wall before cutting and would hold the piece of vessel wall after cutting to prevent it from embolizing in the patient.
• The invention is not restricted to the embodiments shown in the drawing and described herein before and can be varied within the scope of the accompanying claims.

Claims (2)

1. A connector for mechanically connecting hollow structures, in particular small vessels, comprising:

an annular member of deformable material, said member having a center line and a main plane, and being adapted to be permanently deformed by expansion from a first size in a starting position in which it is delivered to a desired anastomosis site, to a second, larger size in a joining position in which it connects the hollow structures,

circumferentially spaced means for joining abutting walls of the hollow structures together, said means including staple-like elements being adapted to be permanently deformed from a starting position in which the connector is delivered to a desired site, to a joining position in which they engage the hollow structures to connect them, said staple-like elements having at least two free ends and being attached to the annular member between its free ends and being tapered from the annular member towards their free ends.

2.-39. (canceled)

Images