US20050267454A1 - Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions - Google Patents

Abstract

A method of thermal ablation using high intensity focused ultrasound energy includes the steps of positioning an ultrasound emitting member, emitting ultrasound energy from the ultrasound emitting member, focusing the ultrasound energy, ablating with the focused ultrasound energy to form an ablated tissue area and removing the ultrasound emitting member.

Description

CROSS-REFERENCE TO RELATED PATENT APPLICATIONS
• This application is a continuation of co-pending U.S. patent application Ser. No. 09/629,194 filed Jul. 31, 2000, which is a continuation-in-part of prior U.S. patent application Ser. No. 09/487,705 filed Jan. 19, 2000, now abandoned, the disclosures of which are incorporated herein by reference.
• This application is related to U.S. patent application Ser. No. 09/487,708 filed Jan. 19, 2000, now abandoned and entitled Methods of Soft Palate Reduction By Thermal Ablation Using High Intensity Focused Ultrasound, Ser. No. 09/487,707 filed Jan. 19, 2000, now U.S. Pat. No. 6,413,254 and entitled Methods of Tongue Reduction By Thermal Ablation Using High Intensity Focused Ultrasound, Ser. No. 09/487,709 filed Jan. 19, 2000, now abandoned and entitled Methods of Tonsil Reduction By Thermal Ablation Using High Intensity Focused Ultrasound, Ser. No. 09/487,706 filed Jan. 19, 2000, now abandoned and entitled Methods of Turbinate Or Other Soft Tissue Reduction By Thermal Ablation Using High Intensity Focused Ultrasound, Ser. No. 09/488,844 filed Jan. 21, 2000, now U.S. Pat. No. 6,361,531 and entitled Focused Ultrasound Ablation Devices Having Malleable Handle Shafts and Methods of Using the Same, and Ser. No. 09/487,710 filed Jan. 19, 2000, co-pending and entitled Focused Ultrasound Ablation Devices Having Selectively Actuatable Ultrasound Emitting Elements and Methods of Using the Same, the disclosures of which are incorporated herein by reference.
• This application is also related to U.S. patent application Ser. No. 09/629,195 filed Jul. 31, 2000, entitled Methods of Soft Palate Reduction Using High Intensity Focused Ultrasound To Form An Ablated Tissue Area Containing A Plurality of Lesions, Ser. No. 09/629,197 filed Jul. 31, 2000, now U.S. Pat. No. 6,409,720 and entitled Methods of Tongue Reduction Using High Intensity Focused Ultrasound To Form An Ablated Tissue Area Containing A Plurality of Lesions, Ser. No. 09/629,842 filed Jul. 31, 2000, now U.S. Pat. No. 6,451,013 and entitled Methods of Tonsil Reduction Using High Intensity Focused Ultrasound To Form An Ablated Tissue Area Containing A Plurality of Lesions and Methods of Turbinate Or Other Soft Tissue Reduction Using High Intensity Focused Ultrasound To Form An Ablated Tissue Area Containing A Plurality of Lesions, the disclosures of which are incorporated herein by reference.
BACKGROUND OF THE INVENTION
• 1. Field of the Invention
• The present invention relates generally to the treatment of anatomical tissue of the head and/or neck with high intensity focused ultrasound energy and, more particularly, to skin rejuvenation by thermal stimulation using high intensity focused ultrasound.
• 2. Brief Description of the Related Art
• When high intensity ultrasound energy is applied to anatomical tissue, significant physiological effects may be produced in the anatomical tissue resulting from thermal and/or mechanical changes or effects in the tissue. Thermal effects include heating of the anatomical tissue; and, when the tissue is heated to a sufficiently high temperature, tissue damage such as coagulative necrosis is produced. In order to produce thermal effects in anatomical tissue, ultrasound emitting members such as transducers have been used to emit ultrasound energy which is applied to anatomical tissue by positioning the ultrasound emitting members adjacent or in contact with the tissue or by coupling the ultrasound emitting members to the tissue via an acoustic coupling medium. By focusing the ultrasound energy at one or more specific focusing zones within the tissue, thermal effect can be confined to a defined location, region, volume or area, and such location, region, volume or area can be remote from the ultrasound emitting member.
• With the use of high intensity focused ultrasound (HIFU), one or more focusing zones at or within a designated target location, region, volume or area within a larger mass, body or area of anatomical tissue can be subjected to high intensity ultrasound energy while tissue surrounding the target area is subjected to much lower intensity ultrasound energy. In this manner, tissue in the target area can be heated to a sufficiently high temperature so as to cause a desired thermal effect such as tissue damage, ablation, coagulation, denaturation, destruction or necrosis while tissue surrounding the target area is not heated to damaging temperatures and, therefore, is preserved. Heating of tissue in a target location, volume, region or area to an ablative temperature creates an ablative lesion in the tissue in the target location, volume, region or area that is desirable in the treatment of various medical conditions, disorders or diseases. For example, the lesion may remain as tissue having altered characteristics or may be naturally degraded and absorbed by the patient's body and thusly eliminated such that the remaining body, mass or area of tissue is of smaller volume or size due to the absence of the ablated tissue.
• The use of high intensity focused ultrasound to eliminate tissue or to alter the characteristics of tissue in a target location, volume, region or area within a larger mass, body or area of anatomical tissue presents many advantages including minimization of trauma and pain for the patient, elimination of the need for a surgical incision, stitches and exposure of internal tissue, avoidance of damage to tissue other than that which is to be treated, altered or removed, lack of a harmful cumulative effect from the ultrasound energy on the surrounding non-target tissue, reduction in treatment costs, elimination of the need in many cases for general anesthesia, reduction of the risk of infection and other complications, avoidance of blood loss, and the ability for high intensity focused ultrasound procedures to be performed in non-hospital sites and/or on an out-patient basis.
• Various devices and/or methods for treating anatomical tissue with ultrasound have been proposed as represented by U.S. Patents No. Re. 33,590 to Dory, U.S. Pat. No. 3,990,452 to Murry et al, U.S. Pat. No. 4,658,828 to Dory, U.S. Pat. No. 4,807,633 to Fry, U.S. Pat. No. 4,858,613 to Fry et al, U.S. Pat. No. 4,951,653 to Fry et al, U.S. Pat. No. 4,955,365 to Fry et al, U.S. Pat. No. 5,033,456 to Pell et al, U.S. Pat. No. 5,036,855 to Fry et al, U.S. Pat. No. 5,054,470 to Fry et al, No. U.S. Pat. No. 5,065,761 to Pell, U.S. Pat. No. 5,080,101 to Dory, U.S. Pat. No. 5,080,102 to Dory, U.S. Pat. No. 5,117,832 to Sanghvi et al, U.S. Pat. No. 5,134,988 to Pell et al, U.S. Pat. No. 5,143,074 to Dory, U.S. Pat. No. 5,150,711 to Dory, U.S. Pat. No. 5,150,712 to Dory, U.S. Pat. No. 5,158,070 to Dory, U.S. Pat. No. 5,222,501 to Ideker et al, U.S. Pat. No. 5,267,954 to Nita, U.S. Pat. No. 5,269,291 to Carter, U.S. Pat. No. 5,269,297 to Weng et al, U.S. Pat. No. 5,295,484 to Marcus et al, U.S. Pat. No. 5,304,115 to Pflueger et al, U.S. Pat. No. 5,312,328 to Nita et al, U.S. Pat. No. 5,318,014 to Carter, U.S. Pat. No. 5,342,292 to Nita et al, U.S. Pat. No. 5,354,258 to Dory, U.S. Pat. No. 5,380,274 to Nita, U.S. Pat. No. 5,391,197 to Burdette et al, U.S. Pat. No. 5,397,301 to Pflueger et al, U.S. Pat. No. 5,409,002 to Pell, U.S. Pat. No. 5,417,672 to Nita et al, U.S. Pat. No. 5,431,621 to Dory, U.S. Pat. No. 5,431,663 to Carter, U.S. Pat. No. 5,447,509 to Mills et al, U.S. Pat. No. 5,474,530 to Passafaro et al, U.S. Pat. No. 5,492,126 to Hennige et al, U.S. Pat. No. 5,501,655 to Rolt et al, U.S. Pat. No. 5,520,188 to Hennige et al, U.S. Pat. No. 5,542,917 to Nita et al, U.S. Pat. No. 5,620,479 to Diederich, U.S. Pat. No. 5,676,692 to Sanghvi et al, U.S. Pat. No. 5,728,094 to Edwards, U.S. Pat. No. 5,730,719 to Edwards, U.S. Pat. No. 5,733,315 to Burdette et al, U.S. Pat. No. 5,735,280 to Sherman et al, U.S. Pat. No. 5,738,114 to Edwards, U.S. Pat. No. 5,746,224 to Edwards, U.S. Pat. No. 5,762,066 to Law et al, U.S. Pat. No. 5,800,379 to Edwards, U.S. Pat. No. 5,800,429 to Edwards, U.S. Pat. No. 5,800,482 to Pomeranz et al, U.S. Pat. No. 5,807,308 to Edwards, U.S. Pat. No. 5,817,049 to Edwards, U.S. Pat. No. 5,823,197 to Edwards, U.S. Pat. No. 5,827,277 to Edwards, U.S. Pat. No. 5,843,077 to Edwards, U.S. Pat. No. 5,871, 524 to Knowlton, U.S. Pat. No. 5,873,845 to Cline et al, U.S. Pat. No. 5,873,902 to Sanghvi et al, U.S. Pat. No. 5,879,349 to Edwards, U.S. Pat. No. 5,882,302 to Driscoll, Jr. et al, U.S. Pat. No. 5,895,356 to Andrus et al, U.S. Pat. No. 5,928,169 to Schatzle et al and U.S. Pat. No. 5,938,608 to Bieger et al.
• In particular, the use of high intensity focused ultrasound to thermally damage, ablate, coagulate, denature, cauterize, necrotize or destroy a target volume of tissue is exemplified by U.S. patents No. Re. 33,590 to Dory, U.S. Pat. No. 4,658,828 to Dory, U.S. Pat. No. 4,807,633 to Fry, U.S. Pat. No. 4,858,613 to Fry et al, U.S. Pat. No. 4,951,653 to Fry et al, U.S. Pat. No. 4,955,365 to Fry et al, U.S. Pat. No. 5,036,855 to Fry et al, U.S. Pat. No. 5,054,470 to Fry et al, U.S. Pat. No. 5,080,101 to Dory, U.S. Pat. No. 5,080,102 to Dory, U.S. Pat. No. 5,117,832 to Sanghvi et al, U.S. Pat. No. 5,143,074 to Dory, U.S. Pat. No. 5,150,711 to Dory, U.S. Pat. No. 5,150,712 to Dory, U.S. Pat. No. 5,295,484 to Marcus et al, U.S. Pat. No. 5,354,258 to Dory, U.S. Pat. No. 5,391,197 to Burdette et al, U.S. Pat. No. 5,431,621 to Dory, U.S. Pat. No. 5,492,126 to Hennige et al, U.S. Pat. No. 5,501,655 to Rolt et al, U.S. Pat. No. 5,520,188 to Hennige et al, U.S. Pat. No. 5,676,692 to Sanghvi et al, U.S. Pat. No. 5,733,315 to Burdette et al, U.S. Pat. No. 5,762,066 to Law et al, U.S. Pat. No. 5,871,524 to Knowlton, U.S. Pat. No. 5,873,845 to Cline et al, U.S. Pat. No. 5,873,902 to Sanghvi et al, U.S. Pat. No. 5,882,302 to Driscoll, Jr. et al, U.S. Pat. No. 5,895,356 to Andrus et al, U.S. Pat. No. 5,928,169 to Schatzle et al and U.S. Pat. No. 5,938,608 to Bieger et al.
• The skin is the largest organ of the body and is highly vulnerable to deterioration due to natural aging and/or exposure to environmental conditions such as sun, wind, heat and cold. The skin includes two primary layers, i.e. the epidermis and the dermis. The epidermis is the outermost layer of the skin and presents a barrier to deter the entry of UV radiation, germs, heat, cold, dirt and gases while deterring the egress of water, blood, minerals, vitamins, hormones and protein. The epidermis is composed of a plurality of sub-layers including several layers of stratified epithelial tissue. The basilar layer of the epidermis includes melanocytes and other epithelial cells. Melanin is produced by the melanocytes and serves to protect the skin from harmful effects of ultraviolet radiation. Skin cells are continuously moving from the lower layers to the upper layers of the epidermis and are sloughed off after they reach the skin surface. The dermis is comprised of dense, irregular connective tissue and contains blood vessels, sweat glands, sebaceous glands, nerves, collagen and elastin. Collagen contributes to the firmness of the skin, and elastin imparts flexibility and durability to the skin. The potential outcome of increased collagen levels in facial skin is a reduction of wrinkles with enhanced skin resilience and a more youthful appearance.
• There is a great demand for methods or procedures to reduce the effects of aging and/or environmental exposure in skin and, in particular, facial skin. Conventional techniques for removing facial wrinkles include cosmetic or plastic surgery, one technique being commonly known as “skin resurfacing”. Cosmetic surgery has numerous drawbacks including invasiveness, trauma, scarring, pain, significant recovery times and high financial cost. Conventional, non-surgical techniques for removing facial wrinkles involve destruction of the epidermis and/or dermis by laser energy used to vaporize the tissue, chemical burns or peels, physical debridement using drills and blasting the skin with a pressurized stream of beads. Such non-surgical techniques typically destroy the epidermis, resulting in temporary and possibly permanent impairment of the skin. For example, patients may be left with various pigmentation problems including blotchiness, a predominantly white complexion and/or the inability to tan.
• U.S. Pat. No. 5,743,904 to Edwards discloses RF ablation of body structures, including fatty tissues in the cheeks, jaw and near the eyes, via electrodes inserted in the tissue. U.S. Pat. No. 5,871,524 to Knowlton discloses the use of RF electrodes and an electrolytic solution to create a reverse thermal gradient in the skin to effect partial denaturation and shrinkage of collagen resulting in tightening of the skin. Ultrasound is alluded to as a possible source of radiant energy to create the reverse thermal gradient. The stimulation of collagen growth by delivery of energy into the superficial layers of the dermis has also been recognized. Lasers having wavelengths that penetrate the epidermis without damage thereto and stimulate the dermis to create collagen are being developed and marketed.
• It has not been previously recognized to thermally stimulate collagen growth by delivery of focused ultrasound energy into superficial layers of the dermis, while avoiding damage to the epidermis, in a minimally invasive, non-traumatic procedure not requiring physical penetration or wounding of the skin and while confining thermal stimulation to a specific target area or areas within the skin.
SUMMARY OF THE INVENTION
• Accordingly, it is a primary object of the present invention to overcome the various disadvantages of prior methods of skin rejuvenation.
• It is also an object of the present invention to effect skin rejuvenation by using high intensity focused ultrasound to stimulate collagen growth.
• Another object of the present invention is to utilize high intensity focused ultrasound to effect wrinkle reduction by increasing collagen levels in skin.
• It is also an object of the present invention to use high intensity focused ultrasound to thermally stimulate collagen growth in skin without impairing the epidermis.
• The present invention also has as an object to use high intensity focused ultrasound to thermally stimulate superficial layers of the dermis to increase collagen growth without damaging the epidermis.
• Still a further object of the present invention is to focus ultrasound energy within the skin to form an internal ablated tissue area beginning a predetermined distance beneath an external surface of the skin in order to stimulate collagen production.
• The present invention also has as an object to focus ultrasound energy, emitted by an ultrasound emitting member, within the skin to form an internal ablated tissue area beginning a predetermined distance from an active face of the ultrasound emitting member in order to stimulate collagen production.
• It is another object of the present invention to use high intensity focused ultrasound to form an ablated tissue area in the skin to a predetermined depth so that deep layers of the skin are not damaged.
• An additional object of the present invention is to focus ultrasound energy within the skin to form an ablated tissue area in the superficial layer of the dermis but not the deep layer of the dermis.
• Some of the advantages of the present invention are that varying intensity levels of ultrasound energy can be delivered to the skin for varying periods of time depending on desired ablative effect, the duration of ultrasound energy delivery or application to the skin needed to accomplish a desired stimulation may be relatively brief depending on desired size for the lesions of the ablated tissue area and/or desired thermal effect on the tissue, the transducer or other member used to emit the ultrasound energy may be stationary or may be movable in order to scan a target area with focused ultrasound, a plurality of individual ablated tissue areas can be formed in the skin with the ablated tissue areas being separate and discontinuous or being contacting, abutting, contiguous or overlapping to form a single continuous ablated tissue area of desired size and/or shape, the ultrasound emitting member can remain stationary or can be moved along the skin to scan a target area with focused ultrasound, the transducer or other member may be designed with a focusing configuration designed to ensure that the lesions of the ablated tissue area have a desired cross-sectional size, begin a desired depth within the skin and have a desired depth, the superficial dermis is thermally damaged to stimulate collagen growth with minimal trauma and pain for the patient, the transducer or other member is positioned externally adjacent or in contact with an external surface of the skin or is acoustically coupled with the skin to form an internal ablated tissue area without damaging the external skin surface and, in particular, the epidermis, no external wound is presented since the epidermis is preserved, and an ablated tissue area of definitive size can be repeatedly and consistently produced.
• These and other objects, advantages and benefits are realized with the present invention as generally characterized in a method of skin rejuvenation or wrinkle reduction by thermal stimulation using high intensity focused ultrasound wherein an ultrasound emitting member is positioned adjacent an external surface of the skin, and ultrasound energy is emitted from the ultrasound emitting member into the tissue of the skin. The Ultrasound energy is focused within the skin at a plurality of focusing zones disposed beneath the external skin surface and contained in a target area coincident with or containing the superficial dermis. The focusing zones are spaced from one another and, due to focusing of the ultrasound energy at the focusing zones, the ultrasound energy is of higher or greater intensity in the tissue at the focusing zones than in the tissue surrounding the focusing zones. The tissue of the skin is heated at the focusing zones by the focused ultrasound energy, thereby forming an ablated tissue area below the external skin surface containing unablated skin tissue and a plurality of lesions at the focusing zones, respectively, at which the tissue of the skin is ablated. Once an ablated tissue area of desired extent has been obtained in the skin, the ultrasound emitting member is removed. In reaction to the lesions, natural production of collagen in the dermis is stimulated. Collagen levels in the skin are thusly increased, resulting in a reduction of wrinkles and enhanced skin resilience for a more youthful appearance.
• The ultrasound emitting member has a focusing configuration causing the ultrasound energy to be focused a predetermined distance from an active face of the ultrasound emitting member and, therefore, from the external surface of the skin, so that the epidermis is undamaged and preserved. Also, the focusing configuration results in formation of lesions of predetermined or known depth in accordance with the length of the focusing zones, the selected ultrasound energy intensities and the selected duration times for ultrasound energy delivery. The lesion depths are selected so that the lesions do not extend deeper than desired in the skin, thereby avoiding damage to the deep layer of the dermis. The plurality of lesions may be non-contacting, with each lesion surrounded by unablated skin tissue. One or more of the plurality of lesions may contact another one of the plurality of lesions. The cross-sectional size of the lesions and the location and arrangement of the focusing zones in the skin result in formation of a specific size ablated tissue area having a specific cross-sectional configuration. A single, discrete ablated tissue area or a plurality of single, discrete ablated tissue areas can be formed in the skin in a single procedure or treatment performed at one time or in multiple procedures or treatments performed at different times. Where a plurality of ablated tissue areas are formed, the ablated tissue areas can be contiguous, contacting, overlapping or in abutment with one another so that the ablated tissue areas together form or create a single ablated tissue area of larger cross-sectional size and/or of a desired cross-sectional configuration.
• Other objects and advantages of the present invention will become apparent from the following description of the preferred embodiments taken in conjunction with the accompanying drawings, wherein like parts in each of the several figures are identified by the same reference characters.
BRIEF DESCRIPTION OF THE DRAWINGS
• FIG. 1 is a broken perspective view, partly schematic, illustrating a high intensity focused ultrasound stimulation or ablation assembly for use in the methods of the present invention.
• FIG. 2 is a broken bottom view of an ultrasound emitting member of a focused ultrasound ablation device of the high intensity focused ultrasound stimulation or ablation assembly.
• FIG. 3 is a broken side view, partly in section, of the ultrasound emitting member and depicting focusing of ultrasound energy in the skin to form an ablated tissue area containing unablated skin tissue and a plurality of lesions at which the skin tissue is ablated.
• FIG. 4 is a broken top view illustrating the surface or cross-sectional configuration of the ablated tissue area ofFIG. 3.
• FIG. 5 is a broken top view illustrating the surface or cross-sectional configuration of an alternative ablated tissue area created in the skin.
• FIG. 6 is a broken top view illustrating the surface or cross-sectional configuration of a plurality of further alternative ablated tissue areas created in the skin.
• FIG. 7 is a broken top view illustrating the surface or cross-sectional configuration of another alternative ablated tissue area created in the skin.
• FIG. 8 is a broken bottom view of an alternative focused ultrasound ablation device having a modified ultrasound emitting member for use in the methods of the present invention.
• FIG. 9 is a broken top view illustrating the surface or cross-sectional configuration of an additional alternative ablated tissue area formed in the skin.
DESCRIPTION OF THE PREFERRED EMBODIMENTS
• A high intensity focused ultrasound ablation or stimulation assembly orsystem10 for use in the methods of the present invention is illustrated inFIG. 1 and is similar to the high intensity focused ultrasound stimulation assembly described in parent U.S. patent application Ser. No. 09/487,705 and prior U.S. patent application Ser. No. 09/487,710, the disclosures of which are incorporated herein by reference. The high intensity focused ultrasound ablation orstimulation assembly10 includes a focused ultrasound ablation orstimulation device12, apower supply14 and acontroller16. The focused ultrasound ablation orstimulation device12 is similar to that described in U.S. patent application Ser. Nos. 09/487,705 and 09/487,710 and includes a focusedultrasound emitting member18, an elongate handle shaft orbody20 having a distal end at which the ultrasound emitting member is disposed and a handle orhandpiece22 coupled to a proximal end of thehandle shaft20. As shown inFIGS. 2 and 3, the ultrasound emitting member includes atransducer24 carried by or within a housing, carrier orcase26. The transducer, which includes one or more individual ultrasound emitting elements or transducer elements, is capable of generating and emitting ultrasound energy in response to being supplied with electrical power frompower supply14. In the case ofultrasound emitting member18, the transducer includes a plurality of individual ultrasound emitting elements ortransducer elements28, each including a piezoelectric element that vibrates to produce ultrasound energy when an electrical current or signal is supplied thereto. Thetransducer elements28 have a focusing configuration or geometry that results in the ultrasound energy produced thereby being focused a fixed distance from the ultrasound emitting member. Thetransducer elements28 have a partial spherical or concave configuration causing the ultrasound energy generated thereby to be focused, as shown by arrows inFIG. 3, at focusing zones F, respectively.
• Thetransducer elements28 are arranged in an array on or inhousing26; and, therefore, thetransducer24 may be considered a multi-array transducer. In the case ofultrasound emitting member18, the transducer elements are arranged in a planar array of three rows R and six columns C, although the transducer elements can be arranged in any number of rows and columns. In the case of focusedultrasound emitting member18, each row R has an equal number of transducer elements, and each column C has an equal number of transducer elements. It should be appreciated that any number of transducer elements can be provided in each row and column and that the number of transducer elements provided in each row and column can be the same or different.
• Thetransducer elements28 can be referenced by their location in the array. For example, thetransducer element28′ in the first row, first column can be designated transducer element R1C1, thetransducer element28″ in the first row, second column can be designated transducer element R1C2 and so on. The transducer elements may be disposed as close as possible to one another; however, it should be appreciated that the spacing between theindividual transducer elements28 of the array can vary so that adjacent transducer elements can be disposed closer together or further apart from one another. As explained further below, thetransducer elements28 are selectively, independently actuatable to selectively emit or not emit ultrasound energy.
• Thetransducer elements28 can be designed in various ways as known in the art. In the case oftransducer24, the transducer elements each comprise a piezoelectric element formed by a layer of piezoelectric material carried byhousing26. The piezoelectric elements are recessed from a planar external lower orbottom surface32 ofhousing26. The piezoelectric elements are curved in a direction inwardly ofsurface32 such that ultrasound energy generated by the piezoelectric elements is emitted from focusedultrasound emitting member18 in a direction perpendicular to surface32 for focusing at the focusing zones F, which are spaced outwardly ofsurface32. Accordingly,surface32 is an active surface or face of the ultrasound emitting member which, when positioned externally on, adjacent or in contact with skin S, results in the ultrasound energy emitted by the transducer being focused at zones F, which will be disposed within the skin S as shown inFIG. 3. When the ultrasound emitting member is positioned on, against or adjacent the skin S at a location aligned with a designatedtarget area34 within the skin S, thetarget area34 being shown in dotted lines inFIGS. 3 and 4, the focusing zones will be disposed at or within the target area as best shown inFIG. 3.
• Each focusing zone F consists of a single point or a plurality of points forming a zone at which the ultrasound energy is focused. Each focusing zone is in line with a central axis of the corresponding transducer element. Each focusing zone is disposed a fixed predetermined distance from a plane containing theactive face32, the predetermined distance for each focusing zone being perpendicular or normal to theactive face32. Therefore, the focusing zones F will also be disposed a predetermined perpendicular distance or a calculable or determinable perpendicular distance from anexternal surface36 of skin S with which theactive face32 is placed in contact or adjacent thereto. Where theactive face32 is placed in contact with theexternal skin surface36, the perpendicular distance that zones F are disposed fromexternal skin surface36 will be the same as the predetermined distance. Where theactive face32 is not placed in contact with theexternal skin surface36 but, rather, is spaced from theexternal skin surface36 by a known amount, for example, the perpendicular distance that zones F are disposed from the external skin surface will correspond to the predetermined distance minus the distance that theactive face32 is spaced from theexternal skin surface36. Where theactive face32 is spaced from theexternal skin surface36, an acoustic coupling medium can be disposed between theexternal skin surface36 and themember18.
• Since the ultrasound is focused at focusing zones F, which are spaced from one another, the ultrasound is of greater or higher intensity at focusing zones F than in tissue surrounding the focusing zones F. Ultrasound energy is thusly focused or concentrated at the focusing zones F, causing the skin at the focusing zones F to be heated to an ablative temperature resulting in formation oflesions38 at the focusing zones, respectively. The tissue is ablated at thelesions38; and, as used herein, “ablated” tissue includes tissue that has been thermally damaged, altered, necrotized, denatured, destroyed, coagulated or cauterized. When all of thetransducer elements28 are actuated, as shown inFIG. 3, heating of skin S will occur at a focusing zone F for each transducer element, resulting in formation of alesion38 at each focusing zone F. The cross-sectional size of the lesions will normally depend on the width of the focusing zones. However, depending on the intensity and duration of the ultrasound energy, thelesions38 may “grow” or “spread” somewhat beyond the focusing zones due to thermal conduction causing the dispersal or spread of heat from the focusing zones. Therefore, depending on procedural parameters and the dimensions of the focusing zones, eachlesion38 has a predetermined or predictable cross-sectional size, i.e. length and width, as well as depth. As an example, eachlesion38 spreads radially outwardly somewhat from the corresponding focusing zone. Thelesions38 have a generally circular surface or cross-sectional configuration as shown inFIGS. 3 and 4 and a specific depth as shown inFIG. 3. Depending on procedural parameters, the dimensions of the focusing zones and/or the type of tissue being ablated, the lesions may or may not have a uniform cross-section along their depth. Where the focusing zones are sufficiently close together, and where the intensity of the ultrasound energy emitted from the transducer elements is sufficiently high and is applied to the tissue for a sufficient duration, the individual lesions may merge to form a single continuous lesion at the target area so that the target area is filled with ablated tissue. However, depending on the spacing between the focusing zones, and depending on the intensity of the ultrasound energy emitted from the transducer elements and the duration of ultrasound energy delivery to the tissue, thelesions38 may remain separate, discrete and not connected to one another as shown inFIGS. 3 and 4 so that thetarget area34 contains unablated skin tissue and thelesions38 at which the tissue of the skin is ablated.FIG. 4 illustrates alesion38 formed in skin S for each focusing zone F wherein thelesions38 are disposed within thetarget area34 but do not merge with, contact, overlap or abut one another. Rather, eachlesion38 is surrounded or circumscribed perimetrically by unablated skin tissue. Thenon-contacting lesions38 and unablated skin tissue are contained in anablated tissue area35 at, coincident, coextensive or aligned with thetarget area34.
• When all of thetransducer elements28 are actuated, an ablated tissue area of specific surface or cross-sectional configuration and size is created within the skin S for thetransducer24 in accordance with the configuration and size of the array, the intensity level of the emitted ultrasound energy, the duration or time of ultrasound energy delivery to the skin, and the size of the lesions. Accordingly, an ablated tissue area having a specific cross-sectional length, width and depth is formed in the skin, with the perimeter of the ablated tissue area circumscribing the array oflesions38.FIGS. 3 and 4 illustrate, in dotted lines, theablated tissue area35 formed in skin S when all of the transducer elements are actuated. Theablated tissue area35 has a generally rectangular surface or cross-sectional configuration or area with a predetermined cross-sectional length and width shown inFIG. 4 and a predetermined cross-sectional depth, shown inFIG. 3, the cross-sectional depth corresponding to the depth of thelesions38. When theultrasound emitting member18 is positioned on, against or adjacent the skin S at a location aligned with a designatedtarget area34 in the skin, theablated tissue area35 will be formed at or coincide with the target area as shown inFIGS. 3 and 4. The ablated tissue area is surrounded, bordered or circumscribed perimetrically by unablated skin tissue, as well as having unablated skin tissue above and below it. Since the focusing zones F begin the predetermined distance or the calculable or determinable distance below theexternal skin surface36, theablated tissue area35 is an internal or subsurface ablated tissue area beginning the predetermined distance or the calculable or determinable distance beneath the external skin surface. Accordingly, thelesions38 andablated tissue area35 begin at a beginning or startingmargin64 located the predetermined or calculable distance below theexternal tissue surface36 and end at an endingmargin66 disposed further below the external tissue surface than the beginning margin, the distance between the beginning and ending margins corresponding to the depth of thelesions38 and, therefore, the depth of theablated tissue area35.
• Thehousing26 can have various external configurations and sizes and can be formed by a portion of the transducer or can mount the transducer elements in various ways. Thehandle shaft20 comprises an elongate, hollow or tubular member of sufficient length to position theultrasound emitting member18 at various operative sites in or on the body of a patient while thehandle22 is maintained at a remote location, typically externally of the patient's body. Thehandle shaft20 could be solid and may comprise a bar or other shaped member. Preferably, thehandle shaft20 is malleable as disclosed in U.S. patent application Ser. No. 09/488,844, the disclosure of which is incorporated herein by reference. Thehandle22 has a forward end coupled to the proximal end ofhandle shaft20 and has a rearward end. Thehandle22 preferably has a configuration to facilitate grasping by a surgeon or other operator. One or more controls or switches42 may be provided onhandle22 to effect operation of the focused ultrasound ablation device.
• One or moreelectrical transmission wires44 is/are connected to thetransducer24 and extend through thehandle shaft20 for connection withpower supply14 in order to transmit or supply electric current from the power supply to the transducer. The power supply may be disposed partly or entirely in the handle, or may be provided separately as a console or unit coupled to the handle shaft or the handle via one or more appropriate transmission wires, which may be the same or different from the one ormore transmission wires44. For example, an electrical cord of suitable length may be removably coupled between thehandle22 and thepower supply14. Thepower supply14 can be designed in various ways as a source or supply of electricity to activate or excitetransducer24 to generate and emit ultrasound energy. For example, the power supply can be designed to provide high frequency alternating electrical current to the transducer via the one or more transmission wires. The power supply may include an RF generator, with or without an amplifier, providing a constant current source. Electrical current provided by the power supply is selectively discharged into all or selected ones of the piezoelectric elements producing vibration of all or selected ones of the piezoelectric elements and, therefore, producing acoustic or ultrasonic waves or energy. The pQwer supply may be separate from the handle but may be operated viacontrols42 on the handle.
• In the case of focusedultrasound ablation device12, atransmission wire44 is provided for each piezoelectric element and, therefore, for each transducer element. As shown inFIG. 3, eachtransmission wire44 is connected to its corresponding piezoelectric element and to the power supply so that the transducer elements are individually driven by or supplied with current from the power supply. Thetransmission wires44 are disposed in respective passages within the housing and may be disposed within a sheath orsleeve46 extending throughshaft20. However, the transmission wires can be disposed externally of the housing and/or the shaft. Thetransmission wires44 are connected to switches (not shown), respectively, for controlling the supply or transmission of current from thepower supply14 to the piezoelectric elements, respectively. The switches can be incorporated in theultrasound emitting member18, thepower supply14 and/or thecontroller16.
• The controller orcontrol unit16 controls the supply of power frompower supply14 totransducer24 so that the transducer can be driven to deliver various intensity levels of ultrasound energy for various durations, periods or lengths of time. In particular, thecontroller16 controls the supply of power from the power supply to the individual piezoelectric elements so that the transducer elements can be individually driven or actuated to emit ultrasound energy. The controller, which may be designed as part of the power supply, will typically include a control panel and display monitor, one or more switches for current control, an input mechanism such as a keyboard, and/or a microprocessor including memory, storage and data processing capabilities for performing various functions. The controller is capable of selectively activating the switches for the transducer elements to “fire” or effect actuation of all or selected ones of the plurality of transducer elements to emit ultrasound energy. For example, switches on thecontroller16 and/or the controller keyboard can be used to selectively couple and decouple theindividual transducer elements28 with the electrical drive signal or current from thepower supply14.
• Input to thecontroller16 provided by the surgeon or other medical personnel determines thetransducer elements28 to be actuated. For example, data entered via the controller keyboard is used to identify the particular transducer elements to be actuated, the transducer elements being identified, for example, by their location or position in the array as explained above. In this manner, the switches of selected transducer elements can be activated to permit transmission of electrical current from the power supply to the piezoelectric elements of the selected transducer elements while the switches of other non-selected transducer elements can remain deactivated to prevent transmission of electrical current thereto when the power supply is actuated or switched to an “on” mode. It should be appreciated that various components and/or methodology can be incorporated in thedevice12, thepower supply14 and/or thecontroller16 to permit selective actuation of selected ones of thetransducer elements28 and that such components and/or methodology would be within the purview of one skilled in the art.
• Various transducers can be used in the methods of the present invention. The piezoelectric elements can be made of various piezoelectric materials such as PZT crystal materials, hard lead, zirconate/lead titanium, piezoelectric ceramic, or lithium-niobate piezoceramic material. The transducer elements can be of various sizes and can have various focusing geometries. The frequency ranges of the transducers can vary depending on clinical needs. Transducer frequencies may be in the range of 0.5 to 12 MHz and, more typically, in the range of 5 to 12 MHz. Preferably, the transducer frequency will allow thermal ablation of the skin to be effected in response to the application or delivery of ultrasound energy to the skin for a relatively short duration or length of time. In accordance with the present invention, the duration or length of time for ultrasound energy delivery or application to the skin preferably ranges from 2 to 60 seconds depending on desired lesion size and/or ablative effect.
• In accordance with the methods of the present invention, high intensity focused ultrasound is used to create an internal ablated tissue area within the skin containing unablated skin tissue and a plurality of lesions at which the tissue of the skin is ablated. In reaction to the lesions, collagen growth in the skin is stimulated. In this manner, collagen levels in the skin are increased resulting in a reduction of wrinkles, enhanced skin resilience and a more youthful appearance.
• The skin S, as shown inFIG. 3, includes an outer or external layer, known as the epidermis E, and an inner or internal layer, known as the dermis DE. The epidermis E is comprised of a plurality of sub-layers including several layers of stratified epithelial tissue and definesexternal skin surface36. The epidermis E has a basilar layer including melanocytes, which produce melanin serving to protect the skin from the harmful effects of ultraviolet radiation. The dermis DE, or “true skin”, is comprised of connective tissue with a varying amount of elastic fibers and numerous blood vessels, lymphatics, nerves and hair follicles H. The dermis DE includes a superficial layer, known as the superficial dermis or papillary layer L, and a deep layer, known as the deep dermis or reticular layer R. The superficial layer L may itself be considered as comprising a plurality of superficial sub-layers forming the superficial dermis. The reticular layer R contains collagen C and elastin, which impart firmness, flexibility and durability to the skin.
• As shown inFIG. 3, theultrasound emitting member18 is placed against the skin S of a patient to position theactive face32 in contact with theexternal skin surface36. The active face is placed at or on theskin surface36 at a location aligned with a desiredtarget area34 in the skin for creation of an ablated tissue area, such location corresponding to an area of the skin that is to be rejuvenated. Theshaft20 may be grasped and manipulated, as necessary, to facilitate positioning of the active face at the desired location on the external skin surface. Typically, the ultrasound emitting member will be placed in contact with skin of the patient's face at a location where a reduction in wrinkles is desired, such as the forehead, cheeks, and the areas around the mouth and eyes. Also, all or specific ones of the transducer elements are selected for actuation or “firing” in accordance with the desired size and configuration for the ablated tissue area and/or the desired number of lesions to be contained in the ablated tissue area. Theablation device12 is programmed via the controller to effect actuation or “firing” of the selected transducer elements when electric current or a signal is supplied to the transducer. Of course, selection and programming for actuation or “firing” of selected transducer elements can be perfomed prior to positioning ofmember18 on the skin surface.
• Once the active face is positioned in contact with the skin S at the desired location, the power supply is activated or switched to an “on” mode to transmit electrical energy to the previously selected transducer elements. In response thereto, the piezoelectric elements corresponding to the selected transducer elements vibrate and produce ultrasound energy, which is focused within the skin S at the corresponding focusing zones F. In the procedure ofFIG. 3, all of the transducer elements are “fired” to emit ultrasound energy, causing the skin to be heated to an ablative temperature at a focusing zone for each transducer element. The skin S at the focusing zones is heated to a temperature in the range of 60 to 90 degrees Celsius for the time required to achieve ablation or thermal damage in the skin. The focusing zones are contained in thetarget area34, which is coincident with or disposed in the superficial dermis L and is thusly disposed between the epidermis E and the deep dermis R. The skin S is heated at the focusing zones to a sufficiently high temperature so as to cause a plurality of subsurface orinternal lesions38 to be simultaneously formed in the skin S and, in particular, in the superficial dermis L, while theultrasound emitting member18 remains external of and does not physically penetrate the skin S.
• Lesions38 have a generally circular surface or cross-sectional configuration as shown inFIGS. 3 and 4 and do not contact or touch one another.Lesions38 contain ablated or damaged skin tissue while the skin tissue surrounding eachlesion38 is not heated to the ablative or thermally damaging temperature and, therefore, is unablated or undamaged. In this manner, eighteen discontinuous or non-contactingindividual lesions38 are formed in the skin as represented inFIG. 4.Lesions38 are contained in the internalablated tissue area35 coincident with thetarget area34, theablated tissue area35 containing thelesions38 and the unablated skin tissue betweenadjacent lesions38. Thelesions38 have a cross-sectional length and width and a depth of known parameters depending on the size and focusing geometry of the transducer elements, the intensity of the ultrasound energy, the temperature to which the skin is heated and the duration of ultrasound energy delivery or application to the skin.
• Due to the predetermined distance and the known length for the focusing zones, thelesions38 and, therefore, theablated tissue area35, begin at the beginning or startingmargin64 located a predetermined or known depth beneath or below theexternal skin surface36 and end at the endingmargin66 located a greater predetermined or known depth beneath theexternal skin surface36, the distance between the beginning and ending margins corresponding to the depth of the lesions and, therefore, the depth of theablated tissue area35. By selecting the appropriate focusing zone depth and treatment parameters, a desired thickness or depth of unablated or undamaged skin tissue between the beginningmargin64 and theexternal tissue surface36 is disposed outside the ablated tissue area. Preferably, the beginning margin is located 50 to 150 micrometers below the external skin surface. In the method ofFIGS. 3 and 4, a layer of unablated skin tissue about 100 micrometers thick is maintained between theexternal skin surface36 and the beginning or startingmargin64 of thelesions38, thusly preserving the epidermis E of the skin S. Thelesions38 have a depth of 50 to 150 micrometers and, preferably, a depth of about 100 micrometers, in the direction perpendicular toskin surface36 such that the ablated tissue area and the lesions terminate or end at the endingmargin66 disposed a depth of about 200 micrometers beneath theexternal skin surface36 at the transducer/tissue interface. Accordingly, there is a perpendicular distance of about 200 micrometers from the external skin surface to the ending margin of the ablated tissue area such that the deep dermis R is undamaged and preserved. By selecting the appropriate focusing zone length and treatment parameters, the depth of the endingmargin66 within the skin is controlled thusly ensuring that the ablated tissue area and lesions do not extend or extend only an insignificant amount into the deep dermis.
• As shown inFIG. 4, theablated tissue area35, which is surrounded above, below and perimetrically by unablated or undamaged skin tissue, has a surface or cross-sectional configuration or area of generally rectangular shape with a cross-sectional width and length varying from 3 mm to 50 mm in either dimension, i.e. 3 mm×3 mm to 50 mm×50 mm or in between, depending on the size of the area to be treated. Although the cross-sectional length and width or other external dimensions of the ablated tissue area can be determined by the locations of the “fired” transducer elements, it should be appreciated that the cross-sectional length and/or width of the ablated tissue area can alternatively be obtained by moving themember18 along the skin as described in U.S. patent application Ser. No. 09/487,705, the disclosure of which is incorporated herein by reference.
• Depending on the desired lesion size and/or thermal effect, ultrasound energy will be delivered or applied to the skin for a duration in the range of 2 to 60 seconds. The emission of ultrasound energy byultrasound emitting member18 is terminated by the surgeon or other operator once lesions of desired size or a desired amount of tissue ablation has been obtained, and themember18 is removed from the patient's skin. In order to terminate the emission of ultrasound energy by the ultrasound emitting member, the power supply is deactivated or switched to an “off” mode so that electrical current is no longer supplied to the selected piezoelectric elements.
• Thelesions38, which typically contain thermally damaged tissue, cause the dermis DE to be stimulated to produce collagen C in the vicinity of the lesions. Thelesions38 are naturally assimilated or degraded and absorbed by the patient's body and are replaced by healthy skin tissue. Accordingly, the level of collagen in the patient's skin increases in the vicinity of the lesions resulting in a reduction of wrinkles, greater resiliency and a more youthful appearance.
• FIG. 5 is representative of a single treatment procedure in accordance with the present invention wherein a subsurface ablatedtissue area135 containing fournon-contacting lesions138 is formed in the skin S. Theablated tissue area135 is similar toablated tissue area35 except that it is of generally square surface or cross-sectional configuration or area and contains four generallycircular lesions138 each surrounded by unablated skin tissue. Theablated tissue area135 can be formed using theultrasound emitting member18 by selecting and “firing” transducer elements R1C1, R1C2, R2C1 and R2C2, for example, to emit ultrasound energy. As described for the procedure illustrated inFIGS. 3 and 4, the ultrasound energy emitted by the selectively “fired” or actuated transducer elements is focused in the skin at a focusing zone for each actuated transducer element, causingsubsurface lesions138 to be formed in the skin at the focusing zones corresponding to transducer elements R1C1, R1C2, R2C1 and R2C2. Thelesions138 are similar tolesions38 but are larger in diametric cross-sectional size thanlesions38. Theablated tissue area135 is surrounded by unablated tissue above, below and perimetrically.
• FIG. 6 is representative of a multiple treatment procedure in accordance with the present invention wherein a plurality of internalablated tissue areas235, each containing unablated skin tissue and a plurality oflesions238, are formed or created in the skin S. Theablated tissue areas235 are spaced from one another, and each contains two generallycircular lesions238 similar tolesions138 except thatlesions238 have a slightly larger cross-sectional diameter thanlesions138. Thelesions238 of eachablated tissue area235 are spaced slightly from one another and are surrounded by unablated skin tissue so as to be non-contacting. Eachablated tissue area235 has a surface or cross-sectional configuration or area of generally rectangular shape. Theablated tissue areas235, which are similar toablated tissue area35 except for their cross-sectional configuration, can be formed usingmember18 as described above by actuating an appropriate pair of transducer elements. Theablated tissue areas235 are typically formed in separate treatments performed at different times. However, it should be appreciated that a plurality of ablated tissue areas, such asablated tissue areas235, can be formed in the skin during a single procedure performed at one time.
• FIG. 7 illustrates in dotted lines anablated tissue area335 of rectangular cross-sectional configuration formed in the skin S and containing six generally circularnon-contacting lesions338 each surrounded by unablated tissue. Thelesions338 andablated tissue area335 are similar to thelesions38 andablated tissue area35 except for the cross-sectional size oflesions338 being different from the cross-sectional size oflesions38. Theablated tissue area335 will typically be formed in a single treatment or procedure. Theablated tissue area335 can be formed using theultrasound emitting member18 by actuating six appropriate transducer elements.
• It should be appreciated that the methods of skin rejuvenation according to the present invention can be performed using focused ultrasound ablation devices wherein the transducer elements of the ultrasound emitting members are not selectively actuatable. For example,FIG. 8 illustrates an alternative focusedultrasound ablation device412 having focusedultrasound emitting member418, which is similar to focusedultrasound emitting member18 except that focusedultrasound emitting member418 includes an array of sixtransducer elements428 actuatable simultaneously or in unison to emit ultrasound energy. Thetransducer elements428 are arranged in two rows and three columns and are used to form an ablated tissue area containing six lesions, such asablated tissue area335. Accordingly, it should be appreciated that various dedicated ultrasound emitting members having different arrays and/or numbers of transducer elements can be provided, with a particular ultrasound emitting member being capable of obtaining a particular ablated tissue area of predetermined size, configuration and number of lesions in response to actuation of all of the transducer elements of the particular ultrasound emitting member.
• FIG. 9 illustrates an alternative, subsurface ablatedtissue area535 formed in the skin S in a manner similar toablated tissue area135. However, the ultrasound energy used to formablated tissue area535 is of higher intensity and/or is applied to the skin for a longer duration than the ultrasound energy used to formablated tissue area135. Accordingly, thelesions538 ofablated tissue area535 have a generally circular surface or cross-sectional configuration larger in diameter than the generally circular cross-sectional configuration oflesions138 due to greater dispersal of heat from the focusing zones. As a result, thelesions538 contact or touch one another but still do not merge sufficiently to fill the entireablated tissue area535 with ablated tissue. Although eachlesion538 is not completely surrounded perimetrically by unablated tissue, there is still some unablated tissue within theablated tissue area535 as shown inFIG. 9 by unablated skin tissue disposed betweenadjacent lesions538. It should be appreciated, therefore, that the ablated tissue areas formed in accordance with the present invention can include a plurality of non-contacting lesions each completely surrounded by unablated tissue and/or a plurality of contacting lesions with unablated tissue between the contacting lesions.
• In the procedures described and illustrated above, the ultrasound emitting member is placed against the skin at a desired location to form an ablated tissue area of final size and configuration in the skin with focused ultrasound energy generated and emitted by the ultrasound emitting member without moving the ultrasound emitting member from the desired location. It should be appreciated, however, that where the largest size ablated tissue area capable of being formed in the skin with the ultrasound emitting member is smaller than the final size and/or different from the final configuration desired for the ablated tissue area, the ultrasound emitting member can be moved along the skin to form an ablated tissue area of desired final size and configuration as explained in U.S. patent application Ser. No. 09/487,705.
• The methods of the present invention allow skin rejuvenation to be performed with minimal trauma and pain for the patient and with faster healing and recovery times. The epidermis is preserved so that no external wound is presented or exposed. A single treatment in accordance with the present invention may be sufficient to reduce wrinkles in a desired area since an ablated tissue area of sufficient size may be obtained with a single treatment. By controlling the delivery of ultrasound energy to the skin, the temperature to which the skin is heated by the ultrasound energy can be controlled to avoid undesired patient responses. The ultrasound emitting members can be provided with sensors for monitoring the amount of ultrasound energy delivered to the skin and/or for detecting the temperature to which the skin is heated, which can be provided as feedback to the controller. The delivery of ultrasound energy to the skin can be controlled to achieve a selected temperature in the skin, a selected amount of ablation, a desired lesion size or a desired duration of ultrasonic energy delivery. The ultrasound emitting members can be disposable or can be designed to be reusable and thusly can be capable of being sterilized to medical standards. The ultrasound emitting members can be provided with disposable covers or guards which can be removed and discarded after use so that the ultrasound emitting members can be reused. The transducer or transducer elements can be removable from the ultrasound emitting members allowing disposability of the ultrasound emitting members and reuse of the transducer or transducer elements in another ultrasound emitting member. The ultrasound emitting members can be immobilized during use as may be accomplished with various types of stabilizing members provided on the shafts or on the ultrasound emitting members. The focused ultrasound ablation devices can be provided with imaging capabilities or can be used with various imaging devices as disclosed in U.S. patent application Ser. No. 09/487,705. The focused ultrasound ablation devices can be provided with cooling systems for cooling the ultrasound emitting members and/or the transducers as disclosed in U.S. patent application Ser. No. 09/487,705. The methods of skin rejuvenation can be performed using an acoustic coupling medium as disclosed in U.S. patent application Ser. No. 09/487,705. A single ultrasound emitting member can be used to form various different ablated tissue areas of various sizes, configurations, and number of lesions depending on the particular transducer elements selected for actuation. A plurality of different ultrasound emitting members having non-selectively actuatable transducer elements can be provided with each ultrasound emitting member having a different array and/or number of transducer elements to obtain a particular ablated tissue area of predetermined size, configuration and number of lesions when all of the transducer elements of the ultrasound emitting members are actuated. Any number of ablated tissue areas can be formed in the skin with each ablated tissue area surrounded by unablated tissue or with the ablated tissue areas contiguous to, in abutment with, contacting or overlapping one another to form a single ablated tissue area. The ultrasound emitting members, the transducers and/or the transducer elements can be moved relative to the tissue to scan target areas with focused ultrasound energy, and such scanning can be accomplished in various diverse ways. The ablated tissue areas can include unablated tissue and a plurality of non-contacting lesions, a plurality of contacting lesions or a combination of contacting and non-contacting lesions. Any number of lesions can be contained in the ablated tissue areas including even and odd numbers of lesions.
• Inasmuch as the present invention is subject to many variations, modifications and changes in detail, it is intended that all subject matter discussed above or shown in the accompanying drawings be interpreted as illustrative only and not be taken in a limiting sense.

Claims (20)

1-26. (canceled)

27. A method of eliminating the need for at least one surgical incision for the treatment of a medical condition by creating a plurality of ablative lesions in an area of tissue of a patient, the method comprising:

positioning an ultrasound emitting member adjacent the area of tissue;

emitting ultrasound energy from the ultrasound emitting member in the range of about 0.5 to 12 MHz into the area of tissue;

moving the ultrasound emitting member along the area of tissue;

focusing the ultrasound energy in a plurality of spaced focusing zones contained in the area of tissue; and

heating the area of tissue at the focusing zones with the focused ultrasound energy for a duration in the range of about 2 to 60 seconds to achieve a temperature in the range of about 60 to 90 degrees Celsius to form the plurality of ablative lesions in the area of tissue.

28. The method ofclaim 27 wherein the area of tissue is in the patient and the step of positioning includes positioning the ultrasound member adjacent the area of tissue from a remote position.

29. The method ofclaim 28 wherein the remote position is external to the patient.

30. The method ofclaim 27 wherein the ultrasound energy is focused below the surface of the tissue while the ultrasound emitting member is moved along the surface of the tissue.

31. The method ofclaim 27 wherein the ultrasound emitting member comprises a plurality of ultrasound emitting elements.

32. The method ofclaim 31 further comprising the step of selecting the ultrasound emitting elements to emit ultrasound energy.

33. The method ofclaim 32 further comprising the step of simultaneously emitting ultrasound energy from the selected ultrasound emitting elements into the area of tissue.

34. The method ofclaim 27 wherein the plurality of ablative lesions form a single continuous lesion.

35. The method ofclaim 27 wherein the step of heating includes forming the plurality of ablative lesions in the area of tissue so that the plurality of ablative lesions do not contact one another.

36. The method ofclaim 27 wherein the step of heating includes forming the plurality of ablative lesions in the area of tissue so that at least one of the plurality of ablative lesions contacts another of the plurality of ablative lesions.

37. The method ofclaim 27 wherein the step of heating includes forming the plurality of ablative lesions in the area of tissue so that the plurality of ablative lesions merge to form a single continuous lesion.

38. A method of eliminating the need for at least one surgical incision for the treatment of a medical condition by creating a plurality of overlapping ablative lesions in an area of tissue of a patient, the method comprising:

positioning an ultrasound emitting member adjacent the area of tissue;

emitting ultrasound energy from the ultrasound emitting member in the range of about 0.5 to 12 MHz into the area of tissue;

focusing the ultrasound energy in a plurality of spaced focusing zones contained in the area of tissue; and

heating the area of tissue at the focusing zones with the focused ultrasound energy for a duration in the range of about 2 to 60 seconds to achieve a temperature in the range of about 60 to 90 degrees Celsius to form the plurality of overlapping ablative lesions in the area of tissue.

39. The method ofclaim 38 wherein the area of tissue is in the patient and the step of positioning includes positioning the ultrasound member adjacent the area of tissue from a remote position.

40. The method ofclaim 39 wherein the remote position is external to the patient.

41. The method ofclaim 38 wherein the ultrasound energy is focused below the surface of the tissue while the ultrasound emitting member is moved along the surface of the tissue.

42. The method ofclaim 38 wherein the ultrasound emitting member comprises a plurality of ultrasound emitting elements.

43. The method ofclaim 42 further comprising the step of selecting the ultrasound emitting elements to emit ultrasound energy.

44. The method ofclaim 43 further comprising the step of simultaneously emitting ultrasound energy from the selected ultrasound emitting elements into the area of tissue.

45. The method ofclaim 38 wherein the plurality of overlapping ablative lesions form a single continuous lesion.

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