US20050159817A1 - Annulus preserving methods and apparatus for placement of intradiscal devices - Google Patents

Abstract

Devices such as a cylindrical bone dowel removed from a vertebra or other human or animal bone, alive or deceased are used to fill holes formed through a vertebral body. Synthetic nucleus replacements or biologic tissue and/or cells may be inserted through the hole. Single or multiple solid, gel, or liquid devices may be placed into the disc. The material may cure in-situ. The intradiscal device may be inserted an instrument that contains a hollow tube. A hollow tube, including the hollow tube of an insertion tool, may be placed into the hole drilled into the vertebra. Cannulated drill bits may placed over guide wires to drill the hole into the vertebra.

Description

REFERENCE TO RELATED APPLICATIONS
• This application is a continuation-in-part of U.S. patent application Ser. No. 10/421,434, filed Apr. 23, 2003, which claims priority from U.S. Provisional Patent Application Ser. Nos. 60/375,185, filed Apr. 24, 2002 and 60/378,132, filed May 15, 2002; the entire content of each being incorporated herein by reference.
FIELD OF THE INVENTION
• This invention relates generally to spinal surgery and, in particular, to methods and apparatus for placing intradiscal devices.
BACKGROUND OF THE INVENTION
• Intradiscal devices are often shaped to fit within the natural concavities of the vertebral endplates that make up the disc space. As shown inFIG. 1, the entrance into the disc space is often narrower than the vertical space within the disc space. Currently surgeons have three choices when inserting devices that fit tight within the interior of the natural disc space. First, they can insert devices that change size or shape within the disc space. There are only a limited number of intradiscal devices that change size or shape within the disc space. Second, surgeons can remove a portion of the vertebrae endplate to allow the insertion of a device that fits tightly in the tallest portion of the disc space. Third, surgeons can distract the vertebrae to insert the intradiscal device. However, at times, the vertebrae cannot be distracted enough to allow the insertion of an intradiscal device that fits tightly within the central portion of the disc space and yet can be inserted past the periphery of the disc space.
SUMMARY OF THE INVENTION
• The present invention involves an osteotomy of a portion of a vertebral endplate and/or vertebral body to allow for easier insertion of a device that fits tightly into a disc space, especially the tallest portion(s) of the disc space. A different aspect of the invention resides in a mechanical device to hold the osteotomized portion of the vertebra against the vertebral body after the intradiscal device is placed. The device may be removed after the pieces of vertebra heal and fuse together.
• Other embodiments of the invention teach devices that may be used to fill holes drilled through a vertebra. For example, such a device may take the form of a cylindrical bone dowel removed from a vertebra or other human or animal bone, alive or deceased. The dowel could be removed with a hole-cutting drill bit. The hole may be drilled into the anterior, lateral, anterior-lateral, posterior, or posterior-lateral portion of the vertebra. A transpsoas approach may be used to the lateral portion of the spine. A paraspinal approach may be used to access the posterior lateral portion of the vertebra. The vertebrae may be distracted prior to inserting the intradiscal device. Screws or pins could be placed into the pedicles of the vertebrae. A distracting instrument could be placed over the screws. Alternatively, distraction could be performed by an instrument placed between the spinous processes.
• In the preferred embodiments, synthetic nucleus replacements or biologic tissue and/or cells are inserted through the hole drilled into the vertebra. The material may be a solid, gel, or liquid. Single or multiple devices may be placed into the disc. The material that is placed into the disc may cure in-situ. The intradiscal device may be inserted an instrument that contains a hollow tube. A hollow tube, including the hollow tube of an insertion tool, may be placed into the hole drilled into the vertebra. Cannulated drill bits may placed over guide wires to drill the hole into the vertebra.
BRIEF DESCRIPTION OF THE DRAWINGS
• FIG. 1 shows a prior art device illustrating the entrance into the disc space;
• FIG. 2A is a side-view drawing illustrating an approach taken according to a method of the present invention;
• FIG. 2B shows a portion removed from the vertebrae;
• FIG. 2C shows how, with the portion removed, the intradiscal device may be more easily inserted;
• FIG. 2D shows the intradiscal device in place in an intervertebral space;
• FIG. 2E shows the replacement of an osteotomized portion;
• FIG. 2F shows anterior and lateral views illustrating a device is used to hold the osteotomized fragment;
• FIG. 2G shows anterior and lateral views of a fragment-holding device with the lateral or side view being shown in cross-section;
• FIG. 3A shows an anterior and lateral view of a hole formed through the vertebrae to receive a cable;
• FIG. 3B is a drawing which shows the holder in place and secured with the cable;
• FIG. 4A is a view of the lateral surface of two vertebrae, a disc, and an osteotomized piece of vertebra;
• FIG. 4B is a is a view of the lateral surface of the spine with the osteotomized bone fragment and the attached AF retracted inferiorly;
• FIG. 4C is a view of the lateral surface of the spine after reattaching the osteotomized bone fragment;
• FIG. 4D is an axial cross-section of a disc, an intradiscal device and attached mesh;
• FIG. 4E is an axial cross-section of a disc wherein a bone fragment and attached AF have been retracted;
• FIG. 4F is a coronal cross-section of the spine, an intradiscal device, and a plate and screws;
• FIG. 5A shows the view of the front of the spine and an alternative embodiment of the invention;
• FIG. 5B is a view of the anterior aspect of the spine after removal of the bone fragments;
• FIG. 5C is a sagittal cross section of the spine, an intradiscal device, and an alternative embodiment of the plate and screws;
• FIG. 5D is a view of the anterior aspect of the spine and the embodiment of the invention shown inFIG. 5C;
• FIG. 5E is an exploded view of the front of the plates and a screw shown inFIG. 5D;
• FIG. 5F is a view of the side of bone and AF graft shown inFIG. 5C;
• FIG. 5G is a sagittal cross section of an alternative embodiment;
• FIG. 6A is a coronal cross-section of the spine, wherein a portion of the upper vertebrae has been osteotomized;
• FIG. 6B is a coronal cross-section of the spine shown inFIG. 6A;
• FIG. 7A is a sagittal cross section of the spine, an intradiscal device, and an alterative embodiment of the plate used to attach the bone fragment;
• FIG. 7B is a view of the anterior aspect of the spine and the embodiment of the plate shown inFIG. 7A;
• FIG. 8A is a sagittal cross section through the spine and an alternative mechanism used to attach the bone fragment;
• FIG. 8B is a sagittal cross section of the spine and an alternative embodiment of the fastening method shown inFIG. 8A;
• FIG. 9A is a coronal cross section of the spine, a drill and osteotomy guide, and an osteotome;
• FIG. 9B is a coronal cross section of the spine and the embodiment of the invention shown inFIG. 9A;
• FIG. 9C is a view of the lateral side of the spine and the guide shown inFIG. 9A;
• FIG. 9D is a view of the lateral side of the spine and an alternative embodiment of a cutting guide;
• FIG. 1OA is a coronal cross section of the spine and an embodiment of the invention with bone fragments having an alternative shape;
• FIG. 10B is a view of the lateral aspect of the spine shown inFIG. 1OA;
• FIG. 11A is a coronal cross section of the spine;
• FIG. 11B is a coronal cross section of the spine drawn during the insertion of an intradiscal device;
• FIG. 11C is a coronal cross section of the spine drawn inFIG. 11B, after the insertion of an intradiscal device;
• FIG. 11D is a view of the lateral surface of the spine drawn inFIG. 11A;
• FIG. 12A is a drawing that shows an alternative approach according to the invention;
• FIG. 12B shows the use of a plate and screws following the procedure ofFIG. 12A;
• FIG. 13A is a lateral view of a device that may used to fill the hole drilled into the vertebra;
• FIG. 13B is a view of the end of a device according to the invention;
• FIG. 13C is a coronal cross section of the spine and an anterior view of the invention drawn inFIG. 13A;
• FIG. 13D is an anterior view of an alternative embodiment of the invention which hasholes1310,1312 that extend to chambers within the device;
• FIG. 14A is an anterior view of an alternative embodiment of the invention wherein the tip of the device rotates relative to the body of the device;
• FIG. 14B is an anterior view of the embodiment of the invention drawn inFIG. 14A;
• FIG. 15A is an anterior view of a vertebra and an alignment guide;
• FIG. 15B is an anterior view of a vertebra and an alternative embodiment of the invention wherein the guide has components that fit against the vertebral endplates;
• FIG. 16A is a coronal cross section of the spine and an alternative embodiment of the invention;
• FIG. 16B is a coronal cross section of the spine and the embodiment of the invention drawn inFIG. 16A, and wherein polymethylmethacrylate (PMMA) has been injected into the hole in the vertebra;
• FIG. 17 is an axial cross section of a disc;
• FIG. 18A is an anterior view of a distraction device; and
• FIG. 18B is an anterior view of the embodiment of the invention drawn inFIG. 18A and the cross section of the pedicles of two vertebrae.
DETAILED DESCRIPTION OF THE INVENTION
• FIG. 2A is a side-view drawing illustrating an approach taken according to a method of the invention. In particular, a tool such as anosteotome202 is used to remove or truncate a lower anterior portion of theupper vertebrae206.FIG. 2B shows the portion removed from the vertebrae.FIG. 2C shows how, with the portion removed, the intradiscal device may be more easily inserted.FIG. 2D shows the intradiscal device in place in the intervertebral space.FIG. 2E shows the replacement of the osteotomized portion. Note that the piece of bone itself may be drilled and/or tapped if necessary, preferably before the osteotomy, to assist with reattachment.
• FIG. 2F provides an anterior and lateral view showing the way in which the device is used to hold the osteotomized fragment.FIG. 2G is an anterior and lateral view of the preferred fragment-holding device, with the lateral or side view being shown in cross-section. As an alternative to a plate and fasteners, a cable system may be used to hold the osteotomized portion in place.FIG. 3A shows an anterior and lateral view of a hole formed through the vertebrae to receive a cable, andFIG. 3B is a drawing which shows the holder in place and secured with the cable.
• It will be appreciated, that although, in the preferred embodiment, only a portion of the upper vertebrae is osteotomized, an anterior portion of the lower vertebrae or both the upper and lower vertebrae may be modified according to the invention, depending upon the area of the spine, patient's physiology and other factors. Indeed, if both the upper and lower vertebrae are osteotomized, the angle of approach may be reduced.
• Additionally, the anterior, lateral, and/or posterior portions of the vertebrae may be osteotomized according to the invention, and the osteotomized bone fragment(s) may include attached Annulus Fibrosus (AF). Although the osteotomy may be limited to either the vertebra above or below the disc, alternatively osteotomies can be performed on the vertebra above and below the disc. An allograft bone and AF component, or an allograft bone and tendon/ligament component, may be used to reconstruct the AF.
• FIG. 4A is a view of the lateral surface of twovertebrae402,404, adisc406, and an osteotomized piece ofvertebra408. The dotted area of the drawing represents the osteotomized bone fragment. The bone fragment and vertebra can be drilled and tapped prior to the osteotomy. A guide as shown inFIGS. 9A and 9B can be used to drill, tap, and cut the vertebra. The Annulus Fibrosus (AF,410) is cut.
• A portion of the AF that is attached to the bone fragment is separated from the remainder of the AF.FIG. 4B is a view of the lateral surface of the spine with theosteotomized bone fragment408 and the attachedAF410 retracted inferiorly, to allow entry into the disc space. The area outlined by the dotted lines in the superior vertebra represents the cut surface of the superior vertebra.
• FIG. 4C is a view of the lateral surface of the spine after reattaching the osteotomized bone fragment. Aplate412 andscrews414 can be used to hold the bone fragment in position. The plate in this case is limited to a single vertebra (area of the drawing with horizontal lines), and does not project beyond the vertebral endplate. The plate may further include a mechanism that prevents the screws from backing out of the plate. For example, C-rings that snap shut after the screws pass by the C-rings can be incorporated into the plate. The screws can pass through the bone fragment and/or portion of the vertebra above the fragment.
• FIG. 4C shows screws passing through the bone fragment and screws that do not pass through the bone fragment. Mesh, as described in my U.S. Pat. No. 6,371,990 is shown attached to the cut and uncut portions of the AF. The mesh is represented by the portion of the drawing with vertical and horizontal lines.FIG. 4D is an axial cross section of a disc, an intradiscal device, and the attached mesh. The intradiscal device is represented by the dotted area of the drawing. Pieces of mesh (area of the drawing with horizontal lines) are shown on the inner and outer surfaces of the AF. Sutures pass through both pieces of mesh and the interposed AF.
• FIG. 4E is an axial cross section of a disc wherein a bone fragment and attached AF have been retracted to allow entry into the disc space.FIG. 4F is a coronal cross section of the spine, anintradiscal device430, and the plate and screws432,434 used to hold thebone fragment436 in position.
• FIG. 5A is the view of the front of the spine and an alternative embodiment of the invention wherein the vertebrae above and below the disc are osteotomized. A portion of the AF (AF′), attached to both bone fragments, is separated from the remaining AF.FIG. 5B is a view of the anterior aspect of the spine after removal of the bone fragments and the portion of the AF that connects the bone fragments. The separated bone fragments and the AF that connects the bone fragments are on the right side of the drawing.
• FIG. 5C is a sagittal cross section of the spine, an intradiscal device502, and an alternative embodiment of the plate and screws504,506. Aflexible material510 preferably connects the plates. The screws may converge or diverge to increase pull-out strength.FIG. 5D is a view of the anterior aspect of the spine and the embodiment of the invention drawn inFIG. 5C.
• FIG. 5E is an exploded view of the front of the plates and a screw drawn inFIG. 5D. The screws can be threaded into the plates, which helps prevent the screws from backing out of the vertebrae. Two or more threads can be used in the portion of the screw that attaches to the plate. The flexible material is shown at510.FIG. 5F is a view of the side of bone and AF graft drawn inFIG. 5C. The graft may be an autograft or an allograft.
• FIG. 5G is a sagittal cross section of an alternative embodiment of the bone andAF graft262. Thegraft262 is preferably held into holes drilled into the vertebrae by interference screws264. The graft can be autograft or allograft. Allografts could be made from tissues other than vertebrae and AF. For example, the graft could be made of bone from the patella and the tibia with patellar tendon connecting the pieces of bone.
• FIG. 6A is a coronal cross section of the spine wherein portion of the upper vertebrae has been osteotomized.FIG. 6B is a coronal cross section of the spine drawn inFIG. 6A, after inserting an intradiscal device. The invention allows distraction of the disc space to insert the intradiscal device. The bone fragment can be advanced along the side of the vertebra, after distraction of the disc space.
• FIG. 7A is a sagittal cross section of the spine, an intradiscal device, and an alterative embodiment of theplate702 used to attach the bone fragment. One ormore arms704 from the bottom of the plate extend under the bone fragment. The arms of the plate also extend through a portion of the AF.FIG. 7B is a view of the anterior aspect of the spine and the embodiment of the plate drawn inFIG. 7A.
• FIG. 8A is a sagittal cross section through the spine and an alternative mechanism used to attach the bone fragment. The mechanism includes a screw withmember802 that is threaded into the vertebra and asecond component804 that extends through one or more holes in the bone fragment connects the bone fragment to the vertebra. The drawing illustrates the use of a flexible, suture or cable like component that is tightened over the bone fragment. A nut that threads to a threaded projection through the bone fragment could also be used to attach the bone fragment.
• FIG. 8B is a sagittal cross section of the spine and an alternative embodiment of the fastening method drawn inFIG. 8A. The fastener may be crimped to a cable extending through the bone fragment, after the bone fragment is placed against the vertebra.
• FIG. 9A is a coronal cross section of the spine, a drill andosteotomy guide902, and anosteotome904.FIG. 9B is a coronal cross section of the spine and the embodiment of the invention drawn inFIG. 9A. The osteotome is drawn extending through the guide and into the vertebra. The guide can also be used to pre-drill andpre-tap holes910,912 in the vertebrae and/or the bone fragment.FIG. 9C is a view of the lateral side of the spine and the guide drawn inFIG. 9A. The dotted area of the drawing represents holes in the guide for drilling and tapping the vertebra. The area of the drawing with closely spaced diagonal lines represents the slot for inserting an instrument to cut the vertebra.FIG. 9D is a view of the lateral side of the spine and an alternative embodiment of the cutting guide. The guide drawn inFIG. 9D does not have a component that extends into the disc space. The guide can be held against the vertebra by pins, screws, or taps placed through the holes in the guide.
• FIG. 1OA is a coronal cross section of the spine and an embodiment of the invention withbone fragments1002 having an alternative shape. The bone fragments area represented by the dotted area of the drawing.FIG. 10B is a view of the lateral aspect of the spine drawn inFIG. 10A.
• FIG. 11A is a coronal cross section of the spine. The AF is shown at1102. The osteotomy extends inside the AF ring.FIG. 11B is a coronal cross section of the spine drawn during the insertion of an intradiscal device. The bone fragment has been removed from the vertebra. Theintradiscal device1104 is inserted into the AF ring. A portion of the nucleus pulposus may be removed to allow room for the intradiscal device. The AF is not cut. The bone fragment may also remain attached to the AF.
• FIG. 11C is a coronal cross section of the spine drawn inFIG. 11B, after the insertion of an intradiscal device.FIG. 11D is a view of the lateral surface of the spine drawn inFIG. 11A. In this case the AF has not been cut.
• FIG. 12A is a drawing that shows an alternative approach according to the invention, wherein aplug1202 is removed from one of the vertebral bodies using a hole saw, for example, to gain access to theintradiscal space1206 without having to cut the annulus. After some form of natural or synthetic disc augmentation orreplacement material1204 is inserted into the disc space, theplug1202 or autograft/allograft may be inserted and optionally secured with aplate1220 and screws.FIG. 12B shows the use of a plate and screws following the procedure ofFIG. 12A. Note that this ‘trans-vertebral’ route could be located relative to the pedicle of a vertebra. The hole could pass through the pedicle, through a portion of the pedicle, through the base of the pedicle, or near the pedicle.
• FIG. 13A is a lateral view of a device that may used to fill the hole drilled into the vertebra. Thedevice1302 is inserted after insertion of the intradiscal device. The device is threaded at1304. The ends1306,1308 of the device are preferably tapered to match the plane of the vertebral endplate and the plane of the periphery of the vertebra. The threads do not extend to the tip of the device, allowing the device to be pushed or impacted into position before the device is screwed into the vertebra. The threads of the device are preferably self-tapping. The device is preferably made of a material that allows bone in-growth. For example, the device may be made of bone, titanium, or tantalum. Alternatively, the device may be made of other materials such as ceramic, chrome cobalt, stainless steel, plastic, or other material. The outer surface of the device may be treated with a material that promotes bone in-growth. For example, the device may be plasma sprayed with titanium, covered with small beads, covered with hydroxy appetite, or other material. One end of the device may configured to except the tip of a screwdriver. The portion of the device that contacts the intradiscal device may be flat, spherical or other appropriate shape.
• FIG. 13B is a view of the end of thedevice1302.FIG. 13C is a coronal cross section of the spine and an anterior view of the invention drawn inFIG. 13A. The area of the drawing with vertical lines represents an intradiscal device such as a nucleus replacement.
• FIG. 13D is an anterior view of an alternative embodiment of the invention which hasholes1310,1312 that extend to chambers within the device. The chambers in the device may be filled with a material that promotes the growth of bone into the device. For example, the device may be filled with bone, including bone removed while drilling a hole in the vertebra. Alternatively, the holes within the device could allow fluids to pass into and/or out of the disc. My patent U.S. Pat. No. 6,685,696, the entire content of which is incorporated herein by reference, teaches hollow devices that pass through the vertebral endplates and into the vertebral body. The method and devices taught in this application teach insertion of a hollow device obliquely through the vertebral body and into the disc space. The hollow chambers may or may not be filled with bone.
• FIG. 13E is a cross section of the embodiment of the invention drawn inFIG. 13D. In an alternative embodiment the lateral end of the device may be closed to help prevent tissue from growing into the device. Tissue within the device could impede the flow of fluids into and out of the device.
• FIG. 14A is an anterior view of an alternative embodiment of the invention wherein the tip of the device (1402) rotates relative to the body of the device. The tip of the device is free to rotate to match the alignment of the vertebral endplates.FIG. 14B is an anterior view of the embodiment of the invention drawn inFIG. 14A. A C-ring1410 has been passed through a hole in the body of the device. The C-ring clips over the shaft of the rotating member. The shaft of the rotating member passes through a hole in the body of the device. The C-ring connects the two components.
• FIG. 15A is an anterior view of a vertebra and analignment guide1504. The alignment guide is placed against the surface of avertebra1506. Aguide wire1508 has been passed through the guide and into the vertebra. A cannulated drill bit may be placed over the guide wire to create the hole in the vertebra.FIG. 15B is an anterior view of a vertebra and an alternative embodiment of the invention wherein the guide has components that fit against the vertebral endplates.
• FIG. 16A is a coronal cross section of the spine and an alternative embodiment of the invention. The disc is depicted with the area of the drawing having vertical lines. Asmall device1602 has been inserted into a hole drilled into the vertebra. The device seals one end of the hole. The device may be threaded or press fit into the position shown in the Figure. The device is placed into the hole after placing the intradiscal device into the disc space.
• FIG. 16B is a coronal cross section of the spine and the embodiment of the invention drawn inFIG. 16A, and wherein polymethylmethacrylate (PMMA,1606) has been injected into the hole in the vertebra. The PMMA and the device hold the intradiscal device in the disc space. Other in-situ curing or expanding materials may be used to replace the device or the PMMA.
• FIG. 17 is an axial cross section of a disc. My co-pending U.S. patent application Ser. No. 10/412,434, incorporated herein by reference, teaches osteotomy of the lateral portion of the vertebra. The technique may be used on any portion of the vertebra. For example, as illustrated in this figure, the vertebra could be osteotomized at the posterior-lateral portion of the vertebra (1702).
• FIG. 18A is an anterior view of a distraction device. The twoend components1802,1804 may be forced apart. Aclip1806 is used to hold the components in an extended position. The clip cooperates with theteeth1808 of the superior component.FIG. 18B is an anterior view of the embodiment of the invention drawn inFIG. 18A and the cross section of the pedicles of two vertebrae. The saddle-shapedend components1802,1804 straddle the pedicles.

Claims (10)

1. A method of placing an intradiscal device, comprising the steps of:

forming a hole through a vertebral body to access an intradiscal space;

placing intradiscal material into the intradiscal space; and

filling the hole formed through the vertebral body with a plug.

2. The method ofclaim 1, wherein the intradiscal device includes one or more solid, gel, or liquid devices.

3. The method ofclaim 1, wherein the intradiscal device cures in situ.

4. The method ofclaim 1, wherein the plug is a bone dowel.

5. The method ofclaim 1, wherein the plug includes a central threaded or gripping section.

6. The method ofclaim 1, wherein the plug includes one or more tapered ends to conform with a vertebral endplate or other bone surface.

7. The method ofclaim 1, wherein the plug is conducive to bony ingrowth.

8. The method ofclaim 1, wherein the plug is hollow.

9. The method ofclaim 1, wherein the intradiscal material includes a nucleus replacement.

10. The method ofclaim 1, wherein the intradiscal material includes biologic tissue and/or cells.

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