US20030149476A1 - Anchoring system for implantable heart valve prostheses - Google Patents
Anchoring system for implantable heart valve prosthesesDownload PDFInfo
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- US20030149476A1 US20030149476A1US10/204,918US20491802AUS2003149476A1US 20030149476 A1US20030149476 A1US 20030149476A1US 20491802 AUS20491802 AUS 20491802AUS 2003149476 A1US2003149476 A1US 2003149476A1
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- United States
- Prior art keywords
- heart valve
- anchoring system
- hook
- shaped elements
- valve prosthesis
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
- A61F2/2418—Scaffolds therefor, e.g. support stents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0008—Fixation appliances for connecting prostheses to the body
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0008—Fixation appliances for connecting prostheses to the body
- A61F2220/0016—Fixation appliances for connecting prostheses to the body with sharp anchoring protrusions, e.g. barbs, pins, spikes
Definitions
- the inventionrelates to an anchoring system for heart valve prostheses which is implantable via the aorta by introduction without any major surgical operation wherein in conventional manner complete opening of the thorax has been required.
- U.S. Pat. No. 5,855,601i.a. is described a so-called stent to which a heart valve prosthesis can be secured.
- This stentis essentially formed of a wire-shaped form storage metal which represents a cylindrical structure within a grid structure.
- the form storage metalcan be folded at temperatures below of 37° C., and shall be guided by means of a catheter via the aorta towards the heart, and there it shall take up the memorized shape after a cooling system has been switched off and a temperature of about 37° C. has been achieved, and shall closely fit in the respective deployed condition on the inside aorta wall.
- an anchoring supportwhich is constructed and designed in such a manner and made of conventional form storage metal (e.g. Nitinol) being suitable in the required temperature range is encountered with problems and requires an appropriate high manufacturing amount since as a rule such a body is cut out of solid material by laser beam cutting.
- conventional form storage metale.g. Nitinol
- hook-shaped elementsare secured immediately to the commissures of a biological heart valve prosthesis which can be removed from a pork heart, e.g., or otherwise to an artificial heart valve prosthesis, which hooks thereof are guided outside through the heart valve prosthesis material, and which in the implanted condition are sticked into the aorta wall and piercing the aorta wall, respectively such that the heart valve prosthesis can be safely secured to the aorta wall.
- the hook-shaped elementscan be sewn on to the heart valve prosthesis.
- a ridgecan be in the form of a flat bar and an elongated plate, respectively, on which at least two hook-shaped elements are designed.
- a base elementfor example, can be designed in a plate-shaped manner of a circular form, wherein the cross-sectional area of the circle can prevent the heart valve prosthesis material from being pierced.
- the hook-shaped elementswhich are arranged on ridges and base elements, respectively, are allowed to be substantially formed in a pin-shaped manner. On that occasion, one or a plurality of barbs are formed on the pin-shaped portion for anchoring in the aorta wall which interlock in or behind the aorta wall after pressing-in.
- the barb shapecan be memorized into a form storage metal such that the barbs protrude outwardly directed above the transition temperatures only, and so cutting-in and piercing the aorta wall is facilitated.
- ridgesare used on which the hook-shaped elements are formed or secured to, these are allowed to be secured to the commissures of a heart valve prosthesis such that they are aligned in the longitudinal direction of the aorta in the implanted state.
- the ridgescan also be particularly advantageous for the ridges to be designed in a helical manner such that they are adapted to the inner contour of the aorta due to the helical shape, and closely fit immediately to this by means of the hooks wherein a greater circumferential area of the inner aorta wall can be covered and an increased degree of closeness can be achieved due to the helical shape.
- ridges having hook-shaped elementsshould have a length which is at least as large as the length of the commissures of the heart valve prosthesis.
- the hook-shaped elementsare made of a form storage metal which maintains that the hook-shaped elements sit flat during the phase of introduction, and only low resistance of introduction and low volume are obtained and the desired shape and erecting the hooks for anchoring in the aorta wall only occur at the site of implantation.
- the effective height of the hook-shaped elementsthen at least should be 2 mm such that they protrude from the heart valve prosthesis in this height, and penetrate into the aorta wall and pierce it, respectively.
- the adjacent hook-shaped elementscan be bent directed towards each other, and such a position can be memorized, respectively, with the use of form storage metal. That results in cramping of the adjacent hook-shaped elements inside the aorta wall with reaching and exceeding the transition temperature, respectively.
- an additional annular memberis allowed to be secured which can also be pressed during the phase of introduction through the aorta, and which demands a smaller volume.
- an elastomer materialsuch as for example a suitable plastic and rubber, respectively, provided with a helical spring as the case may be or only a helical spring as well or a form storage metal can be used.
- the heart valve prosthesis provided with the anchoring system according to the inventioncan be introduced into the aorta by means of a catheter on which a corresponding mechanism is formed wherein the mechanism should maintain deploying the heart valve prosthesis and releasing the heart valve prosthesis placed in the desired position.
- the heart valve prosthesis provided with the anchoring system according to the inventioncan be plonked on and introduced in this position into the aorta. If the site of implantation is reached the balloon is pressurized then, and the heart valve prosthesis is pressed with the hook-shaped elements against the aorta wall, and then the hooks are allowed to be anchored inside the aorta wall wherein using the form storage metal the balloon catheter can also be used for required cooling.
- the surface of the balloon of such a cathetercan be appropriately contoured such that, e.g. the base elements and the ridges, respectively, are safely supported in the phase of passing through the aorta due to the elasticity of the balloon and the appropriately designed contour of the ridges and base elements, respectively, and this retention can be released.
- a catheter having a self-deploying mechanismcan also be used which in turn consists of a form storage metal as well, to ensure the attachment of the heart valve prosthesis with the anchoring system according to the invention.
- a deploying mechanism made of a form storage metalis used, as already mentioned, this is allowed to be designed as an annular element which is secured to the heart valve prosthesis in the area of the outer ring thereof. Such an annular element is allowed then to ensure the stability of the implanted heart valve prosthesis, and an increased sealing function.
- FIG. 1shows an embodiment of the anchoring system according to the invention on a heart valve prosthesis.
- FIG. 1With the embodiment of an anchoring system according to the invention for a heart valve prosthesis 1 as shown in FIG. 1 there are hook-shaped elements 2 formed on ridges 3 , and such each ridge 3 is located on a commissure of the heart valve prosthesis 1 , and is secured there.
- both the ridges 3 and the hook-shaped elements 2are made of a form storage metal as it is available e.g. under the designation of Nitinol.
- the ridges 3are introduced from the inside into the heart valve prosthesis 1 and simply pressed through the commissures of the heart valve prosthesis 1 such that this will be pierced.
- the form storage metalcan be memorized into the shape as shown in FIG. 1 which will be taken up after the transition temperature of 37° C. has been exceeded.
- the hook-shaped elements 2should be inclined almost 90° in the direction towards the longitudinal axis of the ridges 3 as far as possible such that they require a relatively small volume and slightly protrude such that introducing is facilitated, and injuries of the aorta wall can be avoided.
- the number of the hook-shaped elements 2can be readily varied, and moreover it is possible for a plurality of such ridges 3 having hook-shaped elements 2 to be secured to a commissure of the heart valve prosthesis 1 .
- the ridges 3are allowed to be aligned inclined with an angle which is not shown here, wherein two such ridges 3 can also be inclined opposite to each other.
- an additional annular elementcan be secured to the heart valve prosthesis 1 in the area of the outer ring 4 thereof.
- barbscan be formed on the hook-shaped elements 2 and the hooks thereof, respectively, to improve fastening.
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
- The invention relates to an anchoring system for heart valve prostheses which is implantable via the aorta by introduction without any major surgical operation wherein in conventional manner complete opening of the thorax has been required.[0001]
- In the past the most different attempts have been made and solutions have been offered as well wherein heart valve prostheses should be guided through the aorta towards the heart, and be fixedly implanted there after a deploying and stretching over operation.[0002]
- Thus, in U.S. Pat. No. 5,855,601 i.a. is described a so-called stent to which a heart valve prosthesis can be secured. This stent is essentially formed of a wire-shaped form storage metal which represents a cylindrical structure within a grid structure. The form storage metal can be folded at temperatures below of 37° C., and shall be guided by means of a catheter via the aorta towards the heart, and there it shall take up the memorized shape after a cooling system has been switched off and a temperature of about 37° C. has been achieved, and shall closely fit in the respective deployed condition on the inside aorta wall.[0003]
- Due to the limitations of the form storage metal, however, it is difficult for such a stent to be miniaturized and folded up so far in order to be guided through the aorta problem-free, and also to be dimensioned in the deployed state such that then it closely fits on the inside aorta wall, and will be safely supported as well.[0004]
- Moreover, manufacturing an anchoring support which is constructed and designed in such a manner and made of conventional form storage metal (e.g. Nitinol) being suitable in the required temperature range is encountered with problems and requires an appropriate high manufacturing amount since as a rule such a body is cut out of solid material by laser beam cutting.[0005]
- Hence, it is an object of the invention to suggest a possibility wherein heart valve prostheses are allowed to be guided via the aorta towards the heart, and be fixed there.[0006]
- According to the invention this object is solved with the features of[0007]
claim 1. Advantageous embodiments and improvements of the invention result from the features mentioned in the subclaims. - According to the invention, hook-shaped elements are secured immediately to the commissures of a biological heart valve prosthesis which can be removed from a pork heart, e.g., or otherwise to an artificial heart valve prosthesis, which hooks thereof are guided outside through the heart valve prosthesis material, and which in the implanted condition are sticked into the aorta wall and piercing the aorta wall, respectively such that the heart valve prosthesis can be safely secured to the aorta wall.[0008]
- Further additional hook-shaped elements can also be secured to the outer ring of the heart valve prosthesis.[0009]
- On that occasion, the hook-shaped elements can be sewn on to the heart valve prosthesis.[0010]
- However, it is simplier and requires less amount for the hook-shaped elements to be introduced from the inside into the heart valve prosthesis, and at least for the hooks to be pushed through the heart valve prosthesis material wherein it is proper for the hook-shaped elements to be formed on a ridge or with a base element whereby it will be assured that merely the hooks of the hook-shaped elements protrude from the heart valve prosthesis, and the remaining portion having a respective size maintains the retention inside the heart valve prosthesis.[0011]
- Thus, for example, a ridge can be in the form of a flat bar and an elongated plate, respectively, on which at least two hook-shaped elements are designed.[0012]
- A base element, for example, can be designed in a plate-shaped manner of a circular form, wherein the cross-sectional area of the circle can prevent the heart valve prosthesis material from being pierced.[0013]
- The hook-shaped elements which are arranged on ridges and base elements, respectively, are allowed to be substantially formed in a pin-shaped manner. On that occasion, one or a plurality of barbs are formed on the pin-shaped portion for anchoring in the aorta wall which interlock in or behind the aorta wall after pressing-in.[0014]
- On that occasion, the barb shape can be memorized into a form storage metal such that the barbs protrude outwardly directed above the transition temperatures only, and so cutting-in and piercing the aorta wall is facilitated.[0015]
- If ridges are used on which the hook-shaped elements are formed or secured to, these are allowed to be secured to the commissures of a heart valve prosthesis such that they are aligned in the longitudinal direction of the aorta in the implanted state.[0016]
- However, it can also be particularly advantageous for the ridges to be designed in a helical manner such that they are adapted to the inner contour of the aorta due to the helical shape, and closely fit immediately to this by means of the hooks wherein a greater circumferential area of the inner aorta wall can be covered and an increased degree of closeness can be achieved due to the helical shape.[0017]
- If individual hook-shaped elements being otherwise separated from each other are used with base elements these should also be arranged over the commissures in a distributed manner wherein a configuration following the helical shape or a configuration of two counterwound spirals is possible as well.[0018]
- If ridges having hook-shaped elements are used these ridges should have a length which is at least as large as the length of the commissures of the heart valve prosthesis.[0019]
- The ridges secured to the different commissures are not connected to one another.[0020]
- For introducing the heart valve prosthesis with the anchoring system secured thereto it is also favourable if at least the hook-shaped elements are made of a form storage metal which maintains that the hook-shaped elements sit flat during the phase of introduction, and only low resistance of introduction and low volume are obtained and the desired shape and erecting the hooks for anchoring in the aorta wall only occur at the site of implantation.[0021]
- The effective height of the hook-shaped elements then at least should be 2 mm such that they protrude from the heart valve prosthesis in this height, and penetrate into the aorta wall and pierce it, respectively.[0022]
- It is also advantageous to bend the hooks of the various hook-shaped elements in different directions such that a secure fixation of the anchoring system according to the invention can be achieved while taking into account the conditions inside the aorta, pressure and flow conditions in the vicinity of the heart as well.[0023]
- Advantageously, the adjacent hook-shaped elements can be bent directed towards each other, and such a position can be memorized, respectively, with the use of form storage metal. That results in cramping of the adjacent hook-shaped elements inside the aorta wall with reaching and exceeding the transition temperature, respectively.[0024]
- Further, inside the heart valve prosthesis in the area of the outer ring thereof an additional annular member is allowed to be secured which can also be pressed during the phase of introduction through the aorta, and which demands a smaller volume. For this, an elastomer material such as for example a suitable plastic and rubber, respectively, provided with a helical spring as the case may be or only a helical spring as well or a form storage metal can be used.[0025]
- The heart valve prosthesis provided with the anchoring system according to the invention can be introduced into the aorta by means of a catheter on which a corresponding mechanism is formed wherein the mechanism should maintain deploying the heart valve prosthesis and releasing the heart valve prosthesis placed in the desired position.[0026]
- It is also possible to employ a balloon catheter wherein the heart valve prosthesis provided with the anchoring system according to the invention can be plonked on and introduced in this position into the aorta. If the site of implantation is reached the balloon is pressurized then, and the heart valve prosthesis is pressed with the hook-shaped elements against the aorta wall, and then the hooks are allowed to be anchored inside the aorta wall wherein using the form storage metal the balloon catheter can also be used for required cooling.[0027]
- The surface of the balloon of such a catheter can be appropriately contoured such that, e.g. the base elements and the ridges, respectively, are safely supported in the phase of passing through the aorta due to the elasticity of the balloon and the appropriately designed contour of the ridges and base elements, respectively, and this retention can be released.[0028]
- However, a catheter having a self-deploying mechanism can also be used which in turn consists of a form storage metal as well, to ensure the attachment of the heart valve prosthesis with the anchoring system according to the invention.[0029]
- In each case, however, in the phase of passing through the aorta it is appropriate to envelope the heart valve prosthesis in order to avoid undesired injuries of the aorta wall before arriving at the site of implantation, and also to ensure an appropriate thermal insulation with the required cooling as well. After arriving at the site of implantation this enclosure can be teared, and a dislocking mechanism can be activated, respectively, and removed again along with the catheter from the aorta.[0030]
- If a deploying mechanism made of a form storage metal is used, as already mentioned, this is allowed to be designed as an annular element which is secured to the heart valve prosthesis in the area of the outer ring thereof. Such an annular element is allowed then to ensure the stability of the implanted heart valve prosthesis, and an increased sealing function.[0031]
- In the text that follows the invention will be explained in more detail according to an embodiment in which[0032]
- FIG. 1 shows an embodiment of the anchoring system according to the invention on a heart valve prosthesis.[0033]
- With the embodiment of an anchoring system according to the invention for a[0034]
heart valve prosthesis 1 as shown in FIG. 1 there are hook-shaped elements 2 formed onridges 3, and such eachridge 3 is located on a commissure of theheart valve prosthesis 1, and is secured there. - With this embodiment, both the[0035]
ridges 3 and the hook-shaped elements 2 are made of a form storage metal as it is available e.g. under the designation of Nitinol. For the attachment theridges 3 are introduced from the inside into theheart valve prosthesis 1 and simply pressed through the commissures of theheart valve prosthesis 1 such that this will be pierced. - The form storage metal can be memorized into the shape as shown in FIG. 1 which will be taken up after the transition temperature of 37° C. has been exceeded. In the phase of introduction of the[0036]
heart valve prosthesis 1, however, the hook-shaped elements 2 should be inclined almost 90° in the direction towards the longitudinal axis of theridges 3 as far as possible such that they require a relatively small volume and slightly protrude such that introducing is facilitated, and injuries of the aorta wall can be avoided. - With the embodiment as shown herein, five hook-shaped elements each are formed on the[0037]
ridge 3. Altogether, at least fifteen hook-shaped elements should be used, however. - However, the number of the hook-[0038]
shaped elements 2 can be readily varied, and moreover it is possible for a plurality ofsuch ridges 3 having hook-shaped elements 2 to be secured to a commissure of theheart valve prosthesis 1. - On that occasion, the[0039]
ridges 3 are allowed to be aligned inclined with an angle which is not shown here, wherein twosuch ridges 3 can also be inclined opposite to each other. - In the form which is not shown, an additional annular element can be secured to the[0040]
heart valve prosthesis 1 in the area of theouter ring 4 thereof. - In addition, barbs can be formed on the hook-[0041]
shaped elements 2 and the hooks thereof, respectively, to improve fastening.
Claims (15)
1. An anchoring system for implantable heart valve prostheses, characterized in that
hook-shaped elements (2) are secured to the commissures of the heart valve prosthesis (1) the hooks of which are guided in an outward direction through the heart valve prosthesis material.
2. An anchoring system according toclaim 1 , characterized in that
additional hook-shaped elements (2) are secured to the outer ring of said heart valve prosthesis (1).
3. An anchoring system according toclaim 1 orclaim 2 , characterized in that
said hook-shaped elements (2) are sewn on to said heart valve prosthesis (1).
4. An anchoring system according toclaim 1 orclaim 2 , characterized in that
said hook-shaped elements (2) push through said heart valve prosthesis (1), and are supported inside by means of a ridge (3) or a base member.
5. An anchoring system according to any one ofclaims 1 to4 , characterized in that
a plurality of hook-shaped elements (2) are arranged on a common ridge (3), and at least one said ridge (3) each is secured to one commissure.
6. An anchoring system according toclaim 5 , characterized in that
at least two said hook-shaped elements (2) are each located on said one ridge (3).
7. An anchoring system according to any one ofclaims 1 to6 , characterized in that
said ridges (3) are aligned in the longitudinal direction of the aorta.
8. An anchoring system according to any one ofclaims 1 to6 , characterized in that
said ridges (3) are designed in a helical shape.
9. An anchoring system according to any one ofclaims 1 to8 , characterized in that
said ridges (3) at least are as long as said commissures.
10. An anchoring system according to any one ofclaims 1 to9 , characterized in that
at least said hook-shaped elements (2) are made of a form storage metal.
11. An anchoring system according to any one ofclaims 1 to10 , characterized in that
for anchoring in the aorta wall said hook-shaped elements (2) have an effective height of at least 2 mm in the deployed condition wherein they protrude from said heart valve prosthesis (1).
12. An anchoring system according to any one ofclaims 1 to11 , characterized in that
said hook-shaped elements (2) are designed in a pin-shaped manner and with barbs provided thereon.
13. An anchoring system according to any one ofclaims 1 to12 , characterized in that
said hooks of said hook-shaped elements (2) are bent into various directions.
14. An anchoring system according to any one ofclaims 1 to13 , characterized in that
an annular element is secured inside said heart valve prosthesis (1) in the area of said outer ring.
15. An anchoring system according toclaim 14 , characterized in that
said annular element is made of an elastomer material or a form storage metal.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/515,589US7896913B2 (en) | 2000-02-28 | 2006-09-05 | Anchoring system for implantable heart valve prostheses |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10010073ADE10010073B4 (en) | 2000-02-28 | 2000-02-28 | Anchoring for implantable heart valve prostheses |
| DE10010073.2 | 2000-02-28 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US11/515,589ContinuationUS7896913B2 (en) | 2000-02-28 | 2006-09-05 | Anchoring system for implantable heart valve prostheses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US20030149476A1true US20030149476A1 (en) | 2003-08-07 |
Family
ID=7633174
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US10/204,918AbandonedUS20030149476A1 (en) | 2000-02-28 | 2001-02-28 | Anchoring system for implantable heart valve prostheses |
| US11/515,589Expired - Fee RelatedUS7896913B2 (en) | 2000-02-28 | 2006-09-05 | Anchoring system for implantable heart valve prostheses |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US11/515,589Expired - Fee RelatedUS7896913B2 (en) | 2000-02-28 | 2006-09-05 | Anchoring system for implantable heart valve prostheses |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20030149476A1 (en) |
| EP (1) | EP1259193B1 (en) |
| JP (1) | JP4246433B2 (en) |
| AT (1) | ATE488199T1 (en) |
| CY (1) | CY1111106T1 (en) |
| DE (2) | DE10010073B4 (en) |
| DK (1) | DK1259193T3 (en) |
| ES (1) | ES2353733T3 (en) |
| PT (1) | PT1259193E (en) |
| WO (1) | WO2001064137A1 (en) |
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| US6830585B1 (en)* | 2003-01-14 | 2004-12-14 | 3F Therapeutics, Inc. | Percutaneously deliverable heart valve and methods of implantation |
| NL1025830C2 (en)* | 2004-03-26 | 2005-02-22 | Eric Berreklouw | Prosthesis e.g. heart valve secured in place by ring with shape memory material anchor, includes anchor temperature control system |
| US20050137687A1 (en)* | 2003-12-23 | 2005-06-23 | Sadra Medical | Heart valve anchor and method |
| US20050261669A1 (en)* | 1998-04-30 | 2005-11-24 | Medtronic, Inc. | Intracardiovascular access (ICVA™) system |
| US20060178740A1 (en)* | 2005-02-10 | 2006-08-10 | Sorin Biomedica Cardio S.R.L. | Cardiac-valve prosthesis |
| WO2006113496A3 (en)* | 2005-04-15 | 2007-01-04 | Boston Scient Scimed Inc | Valve apparatus, system and method |
| US7186265B2 (en) | 2003-12-10 | 2007-03-06 | Medtronic, Inc. | Prosthetic cardiac valves and systems and methods for implanting thereof |
| US7329279B2 (en) | 2003-12-23 | 2008-02-12 | Sadra Medical, Inc. | Methods and apparatus for endovascularly replacing a patient's heart valve |
| US7381219B2 (en) | 2003-12-23 | 2008-06-03 | Sadra Medical, Inc. | Low profile heart valve and delivery system |
| US7445631B2 (en) | 2003-12-23 | 2008-11-04 | Sadra Medical, Inc. | Methods and apparatus for endovascularly replacing a patient's heart valve |
| US7524331B2 (en) | 2006-04-06 | 2009-04-28 | Medtronic Vascular, Inc. | Catheter delivered valve having a barrier to provide an enhanced seal |
| US7544206B2 (en) | 2001-06-29 | 2009-06-09 | Medtronic, Inc. | Method and apparatus for resecting and replacing an aortic valve |
| US7591848B2 (en) | 2006-04-06 | 2009-09-22 | Medtronic Vascular, Inc. | Riveted stent valve for percutaneous use |
| US7611535B2 (en) | 2001-09-07 | 2009-11-03 | Medtronic, Inc. | Fixation band for affixing a prosthetic heart valve to tissue |
| US7625403B2 (en) | 2006-04-04 | 2009-12-01 | Medtronic Vascular, Inc. | Valved conduit designed for subsequent catheter delivered valve therapy |
| US7682390B2 (en) | 2001-07-31 | 2010-03-23 | Medtronic, Inc. | Assembly for setting a valve prosthesis in a corporeal duct |
| US7712606B2 (en) | 2005-09-13 | 2010-05-11 | Sadra Medical, Inc. | Two-part package for medical implant |
| US7740655B2 (en) | 2006-04-06 | 2010-06-22 | Medtronic Vascular, Inc. | Reinforced surgical conduit for implantation of a stented valve therein |
| US7748389B2 (en) | 2003-12-23 | 2010-07-06 | Sadra Medical, Inc. | Leaflet engagement elements and methods for use thereof |
| US7758606B2 (en) | 2000-06-30 | 2010-07-20 | Medtronic, Inc. | Intravascular filter with debris entrapment mechanism |
| US7780725B2 (en) | 2004-06-16 | 2010-08-24 | Sadra Medical, Inc. | Everting heart valve |
| US7780726B2 (en) | 2001-07-04 | 2010-08-24 | Medtronic, Inc. | Assembly for placing a prosthetic valve in a duct in the body |
| US7824442B2 (en) | 2003-12-23 | 2010-11-02 | Sadra Medical, Inc. | Methods and apparatus for endovascularly replacing a heart valve |
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Also Published As
| Publication number | Publication date |
|---|---|
| DE10010073A1 (en) | 2001-09-27 |
| JP4246433B2 (en) | 2009-04-02 |
| PT1259193E (en) | 2011-01-13 |
| EP1259193B1 (en) | 2010-11-17 |
| ES2353733T3 (en) | 2011-03-04 |
| DE50115708D1 (en) | 2010-12-30 |
| US7896913B2 (en) | 2011-03-01 |
| EP1259193A1 (en) | 2002-11-27 |
| US20070005129A1 (en) | 2007-01-04 |
| ATE488199T1 (en) | 2010-12-15 |
| DK1259193T3 (en) | 2011-01-31 |
| CY1111106T1 (en) | 2015-06-11 |
| JP2003524504A (en) | 2003-08-19 |
| WO2001064137A1 (en) | 2001-09-07 |
| DE10010073B4 (en) | 2005-12-22 |
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