US20030121878A1 - Versatile vial and plug system - Google Patents

Abstract

A versatile vial and plug combination forming a securely sealed closure of the vial. The combination includes a vial with (a) a head with an inner diameter (ID) and an outer diameter (OD); (b) a body with an ID and an OD substantially equal to those of the head; and (c) a neck having an ID less than the ID, and an OD less than the OD, of the head and body, providing a recessed robotic arm pick up area adapted for engagement by automatic equipment. The combination also includes a resilient plug with (a) an inwardly tapered base, (b) a top flange, and (c) a body having an OD that corresponds to or is only slightly greater than the ID of the vial, assuring an interference fit between the plug and the vial, thereby sealing the plug inside the vial upon insertion of the plug in the vial.

Description

CROSS REFERENCE TO RELATED APPLICATION
• This application claims the benefit under Title 35 U.S.C. §119(e) of U.S. Provisional Application No. 60/343,760, filed on Dec. 27, 2001, the contents of which are incorporated by reference.[0001]
TECHNICAL FIELD
• The present invention relates generally to vial and closure systems and, more particularly, to those systems used in laboratory analytical techniques. Typically, these types of systems require a securely sealed closure or cap having a penetrable segment for introduction or withdrawal of material to or from a vial or container on which the cap is mounted. Such systems also require robotic engagement of the vial.[0002]
BACKGROUND OF THE INVENTION
• Chromatograghy is a laboratory technique for the separation and identification of chemical compounds in complex mixtures. Basically, it involves the flow of a mobile (gas or liquid) phase over a stationary phase (which may be a solid or a liquid). Liquid chromatograghy is used for soluble substances and gas (vapor phase) chromatograghy for volatile substances. As the mobile phase moves past the stationary phase, repeated adsorption and desorption of the solute occurs at a rate determined chiefly by its ratio of distribution between the two phases. If the ratio is large enough, the components of the mixture will move at different rates, producing a characteristic pattern, or chromatogragh, from which their identity can be determined.[0003]
• A wide variety of vial and closure systems presently are in use in the chromatograghy market. Most of them require a combination of liners and closures for sealing. All known systems that are used in robotic handling instruments have restricted vial openings: the top opening inner diameter (or “ID”) is smaller than the ID of the main body of the vial. Examples of such systems are illustrated in a brochure titled “Chromatograghy Products Profile” available since 1998 from J. G. Finneran Associates, Inc. of Vineland, N.J.[0004]
• Many conventional containers have a standard snap cap and neck finish. In this basic snap cap design, the extended skirt of the cap secures under a protrusion on the neck of the vial upon sealing the container. The protrusion on the neck of conventional vials is of increased mass, therefore dimensional tolerance is not closely controlled during the molding process. Furthermore, the basic snap cap design does not allow for secure retention of the cap and the vial. Also, the conventional design of the snap cap does not provide for ease of assembling the cap and the vial or for ease of removing the cap from the vial. The snap cap requires the use of downward pressure to apply the cap and upward pressure to remove the cap. Such pressure typically is exerted by the thumb of the user. Advantageously, a snap is heard or felt when the cap is positioned and the container is sealed. No tools are required either to apply or to remove the cap.[0005]
• The snap cap and container are typically made of plastic. This is advantageous because metal is undesirable in laboratory settings. The seal is consistent and provides an adequate short-term (about 8 hours) seal against solvent evaporation. Because the materials used to form the cap and container are not very rigid, however, the designs cannot provide a seal able to withstand contents under high pressure or provide for long-term storage without leakage. The characteristics of the snap cap design have limited use of that design in the chromatograghy market.[0006]
• Instead, three other conventional vial and closure systems are more commonly found in use in the chromatograghy market. The[0007]first system100B includes acrimp cap102B and avial104B as illustrated in FIG. 1B. Thecrimp cap102B is securely retained on theneck finish106B of the (usually glass) vial104B by crimping a metallic (usually aluminum)skirt108B under alip110B on the neck of thevial104B. One advantage of thealuminum crimp cap102B is that it works on containers having either a standard crimp seal or a snap ring. Another advantage is that theneck finish106B of the vial104B has a robotic arm pick uparea120B adapted for engagement by automatic equipment. A disadvantage is that the ID of thevial104B at its top is relatively small, rendering it somewhat difficult to fill thevial104B using, for example and as illustrated in FIG. 2B, apipette150. Another disadvantage is that thealuminum crimp cap102B requires the use of a crimping tool to form a seal. The seal is subject to the amount of squeeze and alignment given by the user. When properly applied, however, thealuminum crimp cap102B provides a good seal against solvent evaporation.
• Still another[0008]common closure system100C for containers involves a standard screwthread neck finish106C on a threadedvial104C and a corresponding screw thread on a threadedcap102C. Closure is attained and a seal obtained by twisting or rotating the threadedcap102C onto thethreads108C of threadedvial104C, as illustrated in FIG. 1C. Thus, screw thread closures require finger torque pressure to apply and remove the threadedcap102C. The seal is subject to the amount of torque applied by the user. When torqued properly, the threadedcap102C provides a good seal although not equivalent to the aluminum crimp seal. Theneck finish106C of the threadedvial104C has a robotic arm pick uparea120C adapted for engagement by automatic equipment. One drawback is, however, that the threadedcap102C can lose torque upon relaxation of the plastic material, from which the typical threadedcap102C is made, which allows thethreaded cap102C to back off thescrew thread108C. In addition, the threadedcap102C can only be used on threadedvials104C. Like thestandard crimp vial104B, a disadvantage is that the ID of the threadedvial104C at its top is relatively small, rendering it somewhat difficult to fill the vial using, for example and as illustrated in FIG. 2C, apipette150.
• A vial and[0009]closure system100D especially well adapted for use in the chromatograghy market is the combination of a plastic orglass shell vial104D and aplastic plug102D. As illustrated in FIG. 1D, theshell vial104D is a simple cylindrical shell, having a substantially constant ID and OD along its entire length. This configuration offers advantages and disadvantages. Unfortunately, theshell vial104D is not adapted for engagement by automatic equipment; it does not have a robotic arm pick up area. On the other hand, the ID of the top opening of theshell vial104D is relatively large, facilitating the process of filling theshell vial104D using, for example and as illustrated in FIG. 2D, apipette150. Theshell vial104D is also sealed easily and effectively by pushing theplug102D into the top opening of theshell vial104D.
• To overcome the shortcomings of the conventional vial and closure systems used in the chromatograghy market, a new system is provided. An object of the present invention is to provide a versatile vial and plug system. A related object is to provide a vial and closure system that can function with robotic analytical instruments. Another object is to provide a system having relatively easy filling (pipetting), filtering, and capping characteristics.[0010]
SUMMARY OF THE INVENTION
• To achieve these and other objects, and in view of its purposes, the present invention provides a versatile vial and plug combination adapted to form a securely sealed closure of the vial. The combination includes a vial with (a) a head defining a first chamber with a first inner diameter and a first outer diameter and extending between a top, with a center opening, and a lower shoulder, (b) a body defining a second chamber with a second inner diameter substantially equal to the first inner diameter and a second outer diameter substantially equal to the first outer diameter and extending between a base and an upper shoulder, and (c) a neck having an inner diameter less than the first inner diameter and an outer diameter less than the first outer diameter and extending between the lower shoulder of the head and the upper shoulder of the body, providing a recessed robotic arm pick up area adapted for engagement by automatic equipment. The combination also includes a resilient plug with (a) an inwardly tapered base, (b) a top flange, and (c) a body extending from the base to the top flange and having an outer diameter that corresponds to or is only slightly greater than the first inner diameter of the vial, assuring an interference fit between the plug and the vial, thereby sealing the plug inside the vial upon insertion of the plug in the vial.[0011]
• It is to be understood that both the foregoing general description and the following detailed description are exemplary, but are not restrictive, of the invention.[0012]
BRIEF DESCRIPTION OF THE DRAWING
• The invention is best understood from the following detailed description when read in connection with the accompanying drawing. It is emphasized that, according to common practice, the various features of the drawing are not to scale. On the contrary, the dimensions of the various features are arbitrarily expanded or reduced for clarity. Included in the drawing are the following figures:[0013]
• FIG. 1A illustrates a vial and plug combination in accordance with the present invention;[0014]
• FIG. 1B illustrates a conventional crimp vial with its seal in place;[0015]
• FIG. 1C illustrates a conventional threaded vial with its closure in place;[0016]
• FIG. 1D illustrates a conventional shell vial with its plug in place;[0017]
• FIG. 2A illustrates the vial shown in FIG. 1A with the plug removed and as the vial is being filled using a pipette;[0018]
• FIG. 2B illustrates the crimp vial shown in FIG. 1B with the seal removed and as the vial is being filled using a pipette;[0019]
• FIG. 2C illustrates the threaded vial shown in FIG. 1C with the closure removed and as the vial is being filled using a pipette;[0020]
• FIG. 2D illustrates the shell vial shown in FIG. 1D with the plug removed and as the vial is being filled using a pipette;[0021]
• FIG. 3 is an expanded view of the vial and plug combination shown in FIG. 1A, with the plug illustrated in side view and separated from the vial illustrated in perspective view;[0022]
• FIG. 4 is a top view of the vial illustrated in FIG. 3;[0023]
• FIG. 5 is a cross-sectional view of the vial shown in FIG. 3, taken along the line[0024]5-5 of FIG. 4;
• FIG. 6 is a side view of the vial shown in FIG. 3;[0025]
• FIG. 7 is a top view of the plug illustrated in FIG. 3;[0026]
• FIG. 8 is a cross-sectional view of the plug shown in FIG. 3, taken along the line[0027]8-8 of FIG. 7;
• FIG. 9 is a side view of the plug shown in FIG. 3;[0028]
• FIG. 10A illustrates a tubular filter upon insertion into the vial of the present invention having an unfiltered solution;[0029]
• FIG. 10B illustrates the tubular filter shown in FIG. 10A in place within the vial as sealed by the plug of the present invention, yielding a filtered solution;[0030]
• FIG. 11A illustrates a hollow tubular filter upon insertion into the vial of the present invention having an unfiltered solution; and[0031]
• FIG. 11B illustrates the hollow tubular filter shown in FIG. 11A in place within the vial as sealed by the plug of the present invention, yielding a filtered solution.[0032]
DETAILED DESCRIPTION OF THE INVENTION
• Referring now to the drawing, in which like reference numbers refer to like elements throughout, FIG. 3 shows the vial and plug[0033]combination50 in accordance with the present invention. Vial and plugcombination50 includes avial10 and aresilient plug30 having an axis, a.Vial10 may be plastic or glass.Plug30 is a resilient plastic.
• Now referring to details of[0034]vial10 as better seen in FIGS.4-6,vial10 has three (typically integral or monolithic) sections: ahead12 defining a first chamber, abody16 defining a second chamber, and aneck14 disposed betweenhead12 andbody16.Head12 extends between a top18, with acenter opening20, and alower shoulder22.Body16 extends between a base24 and anupper shoulder26.
• In one example embodiment, the walls of[0035]vial10 are about 0.084 cm (0.033 inches) thick. The total length ofvial10 betweenbase24 and top18 is about 3.188 cm (1.255 inches). The length ofhead12, the distance betweenlower shoulder22 and top18, is about 0.533 cm (0.210 inches). The distance betweenupper shoulder26 and top18 is about 1.031 cm (0.406 inches).
• The ID and outer diameter (or “OD”) of the chambers defined by[0036]head12 andbody16 are substantially equal. In the exemplary embodiment, the ID is about 0.965 cm (0.380 inches) and the OD is about 1.160 cm (0.457 inches).Neck14 extends betweenlower shoulder22 ofhead12 andupper shoulder26 ofbody16, providing a recessed robotic arm pick uparea90 adapted for engagement by automatic equipment. This robotic arm pick uparea90 is highlighted in FIG. 1A. The ID and OD ofneck14 are substantially less than the ID and OD common to head12 andbody16. In the exemplary embodiment, the OD ofneck14 is about 0.856 cm (0.337 inches).
• In the embodiment of[0037]vial10 shown in FIG. 1A,lower shoulder22 andupper shoulder26 are defined by sharp angles. It may be advantageous, however, to round those angles. Therefore, the alternative embodiment shown in FIGS. 5 and 6 illustratesvial10 having curved transitions betweenlower shoulder22 ofhead12 andneck14 and betweenneck14 andupper shoulder26 ofbody16.
• [0038]Head12 has aprotrusion80adjacent top18. In the exemplary embodiment, the length ofprotrusion80 is about 0.079 cm (0.031 inches).Protrusion80 functions to form a catch or undercut, facilitating retention ofplug30 invial10.
• The relatively large ID of[0039]head12, defined by the diameter ofcenter opening20 and the first chamber, in comparison to conventional vials, permits the user to fillvial10 easily. Such filling is typically done using a pipette, as shown in FIG. 2A. This characteristic ofvial10 offers a major advantage over conventional vials, especially those used in chromatograghy applications.
• As illustrated in FIG. 3, plug[0040]30 has three (typically integral or monolithic) sections: atop flange32, abody34, and an inwardly taperedbase36.Plug30 may be made of silicone rubber, butyl rubber, natural rubber or any other resilient material which can be used as molded or bonded to an inert material such as polytetrafluoroethylene (sold under the trademark Teflon of E. I. DuPont deNemours & Co., Inc. of Wilmington, Del.). Polytetrafluoroethylene is “a highly stable thermoplastic tetrafluoroethylene homopolymer composed of at least 20,000C₂F₄monomer units linked into very long unbranched chains.” Merck Index at 7560.
• Now referring to details of[0041]plug30 as best seen in FIGS.7-9,top flange32 ofplug30 has anunderside44 and acentral opening38 in which is disposed a central,upraised button40.Button40 can be pierced with an instrument needle and reseal itself after retraction of the needle. In fact, plug30 assures excellent resealability of vial and plugcombination50 after multiple needle penetrations.Button40 can be provided with a slit42 (preferably, but not essentially, an X-shaped slit) which permits plug30 to be easily pierced with thin-walled instrument needles.
• The taper of[0042]base36 facilitates insertion ofplug30 into center opening20 ofvial10. Thus, at its bottom,base36 has an OD which is less than the ID ofhead12 ofvial10.Body34, the OD of which corresponds to or is only slightly greater than the ID ofhead12 ofvial10, extends vertically upward frombase36 totop flange32 and facilitates alignment ofplug30 andvial10, as they are assembled. Although the OD ofbody34 might be constant (i.e.,body34 may be substantially vertical and straight), it is preferable thatbody34 have a slight outward angular taper. An angular shape allows for tolerance variations and assures an interference fit betweenplug30 andvial10, thereby sealingplug30 insidevial10.
• In the exemplary embodiment, the thickness of[0043]button40, at least at its center, is about 0.051 cm (0.02 inches). The diameter ofcentral opening38 is about 0.813 cm (0.320 inches). The length offlange32 is about 0.152 cm (0.06 inches) and the width offlange32, which also defines the maximum width ofplug30, is about 1.207 cm (0.475 inches).
• The length of[0044]plug30 between the top46 and the bottom48 (i.e., the overall length of plug30) is about 0.559 cm (0.220 inches) in the exemplary embodiment. The length betweentop46 and theflat portion52 ofbutton40 is about 0.330 cm (0.130 inches). The length betweenbottom48 and thejunction54, betweenbody34 andbase36, is about 0.152 cm (0.060 inches). The diameter ofbase36 is about 1.029 cm (0.405 inches) and the diameter of the base36 betweenapical points56 is about 0.770 cm (0.303 inches). Finally, the diameter ofplug30 at the points whereunderside44contacts body34 is about 1 cm (0.390 inches).
• In practice, the user aligns[0045]base36 ofplug30 with center opening20 ofhead12 ofvial10 and pushes downward onplug30. The resultant downward movement ofplug30 towardvial10 causesbody36 ofplug30 to engage the walls ofhead12 ofvial10 defining the first chamber. The downward force overcomes the friction generated by the interference fit and is maintained by the user untilunderside44 oftop flange32 contacts top18 ofhead12. At that point, plug30 is fully inserted intovial10. A tactile (and, at least on occasion, an audible) seating informs the user that insertion has been completed.
• Thus, vial and plug[0046]combination50 permits ease of sealingvial10 by simply pushingplug30 into the ID ofhead12 ofvial10. The integrity of the seal betweenvial10 and plug30 provides another advantage to vial and plugcombination50. Specifically, in-house tests conducted with a volatile solvent showed evaporation loss equivalent to that of a crimped aluminum seal. Given the excellent sealing properties, assured by multiple interference contacts betweenbody34 ofplug30 and points x and y of vial10 (see FIG. 6), vial and plugcombination50 can be used in long-term storage.
• Typically, in chromatograghy applications, the user must fill a syringe with solution, attach a filter, and then fill the vial. Three, separate components are required (namely a syringe, a plunger, and a filter) to obtain a filtered solution. Vial and plug[0047]combination50 gives the user the ability to filter solutions invial10 by simply pressing atubular filter70 or a hollow tubular filter78 (with one end closed) intovial10. FIGS. 10A and 11A illustratetubular filter70 and hollowtubular filter78, respectively, upon insertion intovial10 having anunfiltered solution72. As shown in FIGS. 10B and 11B,tubular filter70 and hollowtubular filter78, respectively, are in place withinvial10 as sealed byplug30, yielding a filteredsolution74. Therefore, vial and plugcombination50 offers improved economy: the conventional three-piece syringe, plunger, and filter are replaced with one unit.
• Although illustrated and described above with reference to certain specific embodiments, the present invention is nevertheless not intended to be limited to the details shown. Rather, various modifications may be made in the details within the scope and range of equivalents of the claims and without departing from the spirit of the invention.[0048]

Claims (20)

What is claimed:

1. A versatile vial and plug combination adapted to form a securely sealed closure of the vial, the combination comprising:

a vial having:

(a) a head defining a first chamber with a first inner diameter and a first outer diameter and extending between a top, with a center opening, and a lower shoulder,

(b) a body defining a second chamber with a second inner diameter substantially equal to the first inner diameter and a second outer diameter substantially equal to the first outer diameter and extending between a base and an upper shoulder, and

(c) a neck having an inner diameter less than the first inner diameter and an outer diameter less than the first outer diameter and extending between the lower shoulder of the head and the upper shoulder of the body, providing a recessed robotic arm pick up area adapted for engagement by automatic equipment; and

a resilient plug having:

(a) a base,

(b) a top flange, and

(c) a body extending from the base to the top flange and having an outer diameter that corresponds to or is only slightly greater than the first inner diameter of the vial, assuring an interference fit between the plug and the vial, thereby sealing the plug inside the vial upon insertion of the plug in the vial.

2. The versatile vial and plug combination as recited inclaim 1 further comprising a filter adapted for insertion into the vial before insertion of the plug in the vial.

3. The versatile vial and plug combination as recited inclaim 1 wherein multiple interference contacts exist between the body of the plug and the vial upon insertion of the plug in the vial.

4. The versatile vial and plug combination as recited inclaim 1 wherein the base of the plug is tapered inwardly to facilitate insertion of the plug in the vial.

5. The versatile vial and plug combination as recited inclaim 1 wherein the body of the plug has an outward angular taper.

6. The versatile vial and plug combination as recited inclaim 1 wherein the plug has a button made of a material that can be pierced by an instrument and resealed after removal of the instrument.

7. The versatile vial and plug combination as recited inclaim 1 wherein the plug has a button with a slit permitting the plug to be pierced by an instrument and resealed after removal of the instrument.

8. The versatile vial and plug combination as recited inclaim 1 wherein the flange of the plug has an underside contacting the top of the head of the vial when the plug is fully inserted into the vial.

9. The versatile vial and plug combination as recited inclaim 1 wherein the head has a protrusion adjacent the top, the protrusion facilitating retention of the plug in the vial upon insertion of the plug into the vial.

10. The versatile vial and plug combination as recited inclaim 1 wherein a first transition exists between the lower shoulder and the neck and a second transition exists between the neck and the upper shoulder, the transitions being formed by sharp angles.

11. The versatile vial and plug combination as recited inclaim 1 wherein a first curved transition exists between the lower shoulder and the neck and a second curved transition exists between the neck and the upper shoulder.

12. The versatile vial and plug combination as recited inclaim 1 wherein the vial is one of plastic or glass.

13. The versatile vial and plug combination as recited inclaim 1 wherein the resilient plug is made of a material selected from the group consisting of rubber and plastic.

14. The versatile vial and plug combination as recited inclaim 13 wherein the resilient plug is also made of polytetrafluoroethylene.

15. A versatile vial and plug combination adapted to form a securely sealed closure of the vial, the combination comprising:

a vial having:

(a) a head defining a first chamber with a first inner diameter and a first outer diameter and extending between a top, with a center opening, and a lower shoulder, the head having a protrusion adjacent the top which facilitates retention of the plug in the vial upon insertion of the plug into the vial,

(b) a body defining a second chamber with a second inner diameter substantially equal to the first inner diameter and a second outer diameter substantially equal to the first outer diameter and extending between a base and an upper shoulder, and

(c) a neck having an inner diameter less than the first inner diameter and an outer diameter less than the first outer diameter and extending between the lower shoulder of the head and the upper shoulder of the body, providing a recessed robotic arm pick up area adapted for engagement by automatic equipment; and

a resilient plug having:

(a) a base tapered inwardly to facilitate insertion of the plug in the vial,

(b) a top flange having an underside contacting the top of the head of the vial when the plug is fully inserted into the vial,

(c) an outward angular tapered body extending from the base to the top flange and having an outer diameter that corresponds to or is only slightly greater than the first inner diameter of the vial, assuring an interference fit between the plug and the vial, thereby sealing the plug inside the vial upon insertion of the plug in the vial, and

(d) a button that (i) is made of a material which can be pierced by an instrument and resealed after removal of the instrument, or (ii) has a slit permitting the plug to be pierced by an instrument and resealed after removal of the instrument,

wherein multiple interference contacts exist between the body of the plug and the vial upon insertion of the plug in the vial.

16. The versatile vial and plug combination as recited inclaim 15 further comprising a filter adapted for insertion into the vial before insertion of the plug in the vial.

17. The versatile vial and plug combination as recited inclaim 15 wherein a first transition exists between the lower shoulder and the neck and a second transition exists between the neck and the upper shoulder, the transitions being formed by (i) sharp angles, or (ii) curves.

18. The versatile vial and plug combination as recited inclaim 15 wherein the vial is one of plastic or glass.

19. The versatile vial and plug combination as recited inclaim 15 wherein the resilient plug is made of a material selected from the group consisting of rubber and plastic.

20. The versatile vial and plug combination as recited inclaim 19 wherein the resilient plug is also made of polytetrafluoroethylene.

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