US20030120338A1 - Advanced endovascular graft - Google Patents

Abstract

This invention is a system for the treatment of body passageways; in particular, vessels with vascular disease. The system includes an endovascular graft with a low-profile delivery configuration and a deployed configuration in which it conforms to the morphology of the vessel or body passageway to be treated as well as various connector members and stents. The graft is made from an inflatable graft body section and may be bifurcated. One or more inflatable cuffs may be disposed at either end of the graft body section. At least one inflatable channel is disposed between and in fluid communication with the inflatable cuffs.

Description

RELATED APPLICATIONS
• This application is a continuation of U.S. patent application Ser. No. 10/029,559, filed Dec. 20, 2001, entitled “Advanced Endovascular Graft” by Chobotov et al. In addition, this application is related to U.S. patent application Ser. No. 10/029,570, filed Dec. 20, 2001, entitled “Method and Apparatus for Shape Forming Endovascular Graft Material” by Chobotov et al., U.S. patent application Ser. No. 10/029,584, filed Dec. 20, 2001, entitled “Endovascular Graft Joint and Method for Manufacture” by Chobotov et al., U.S. patent application Ser. No. 10/029,557, filed Dec. 20, 2001, entitled “Method and Apparatus for Manufacturing an Endovascular Graft Section”, by Chobotov et al. All of the above applications are commonly owned and were filed on even date herewith. All of the above applications are hereby incorporated herein by reference, each in its entirety.[0001]
BACKGROUND
• The present invention relates to a system for the treatment of disorders of the vasculature. More specifically, the invention relates to a system for the treatment of disease or injury that potentially compromises the integrity of a flow conduit in the body. For example, an embodiment of the invention is useful in treating indications in the digestive and reproductive systems as well as indications in the cardiovascular system, including thoracic and abdominal aortic aneurysms, arterial dissections (such as those caused by traumatic injury), etc. Such cardiovascular indications often require intervention due to the severity of the sequelae, which frequently is death.[0002]
• For indications such as abdominal aortic aneurysms, traditional open surgery is still the conventional and most widely-utilized treatment when the aneurysm's size has grown to the point that the risk of aneurysm rupture outweighs the drawbacks of surgery. Surgical repair involves replacement of the section of the vessel where the aneurysm has formed with a graft. An example of a surgical procedure is described by Cooley in Surgical Treatment of Aortic Aneurysms, 1986 (W. B. Saunders Company).[0003]
• Despite its advantages, however, open surgery is fraught with high morbidity and mortality rates, primarily because of the invasive and complex nature of the procedure. Complications associated with surgery include, for example, the possibility of aneurysm rupture, loss of function related to extended periods of restricted blood flow to the extremities, blood loss, myocardial infarction, congestive heart failure, arrhythmia, and complications associated with the use of general anesthesia and mechanical ventilation systems. In addition, the typical patient in need of aneurysm repair is older and in poor health, facts that significantly increase the likelihood of complications.[0004]
• Due to the risks and complexities of surgical intervention, various attempts have been made to develop alternative methods for treating such disorders. One such method that has enjoyed some degree of success is the catheter-based delivery of a bifurcated stent-graft via the femoral arteries to exclude the aneurysm from within the aorta.[0005]
• Endovascular repair of aortic aneurysms represents a promising and attractive alternative to conventional surgical repair techniques. The risk of medical complications is significantly reduced due to the less-invasive nature of the procedure. Recovery times are significantly reduced as well, which concomitantly diminishes the length and expense of hospital stays. For example, open surgery requires an average six-day hospital stay and one or more days in the intensive care unit. In contrast, endovascular repair typically requires a two-to-three day hospital stay. Once out of the hospital, patients benefiting from endovascular repair may fully recover in two weeks while surgical patients require six to eight weeks.[0006]
• Despite these and other significant advantages, however, endovascular-based systems have a number of shortcomings. Present bifurcated stent-grafts require relatively large delivery catheters, often up to 24 French and greater in diameter. These catheters also tend to have a high bending stiffness. Such limitations result in the need for a surgical cut-down to deliver the stent-graft and make delivery through the often narrow and irregular arteries of diseased vessels difficult and risky. Because of this, endovascular treatment of aortic aneurysmal disease is not available to many patients who could otherwise benefit from it. For instance, women statistically tend to have smaller vessels and therefore some are excluded from many current endovascular therapies simply due to this reason. There is therefore a need for an endovascular stent-graft capable of being delivered via a smaller and more flexible delivery catheter. Even greater advantages may be realized if such an endovascular stent-graft is capable of being delivered percutaneously.[0007]
• Further, an endovascular stent-graft must withstand tremendous pulsatile forces over a substantial period of time while remaining both seated and sealed within the vessel. In order to achieve these objectives, the device, which may comprise component parts and/or materials, must remain intact. The device must resist axial migration from the site of deployment while being subjected to significant pulsatile forces, and it should have sufficient radial compliance to conform to the vessel anatomy within which it is deployed so as to prevent blood leakage between the device and the vessel wall at both its proximal, or cephalic, end as well as at its distal, or caudal end or ends (where the net force may be retrograde). Such a device should conform to the morphology of the treated vessel, without kinking or twisting, over the life of the patient.[0008]
SUMMARY
• The present invention generally is directed to a system for the endovascular treatment of body passageways that includes a medical device implantable within a body lumen such as a blood vessel. Some embodiments of this invention include an endovascular graft for treating vascular disease.[0009]
• One embodiment includes a graft with a graft body section having a proximal end and a distal end, and, disposed or affixed on at least one end, a connector member having one or more connector member connector elements. The connector member may be embedded within multiple layers of the graft body section. A stent may be coupled or affixed to the one or more connector member connector elements via one or more stent connector elements. The graft may include a proximal stent and connector member only, a distal stent and connector member only, or both proximal and distal stents and their respective connector members.[0010]
• Both the connector member connector elements and the stent connector elements may have a proximal end and a distal end that comprise opposing shoulder portions. The graft may further have one or more coupling members, such as a wire coil, configured to couple or connect the one or more connector member connector elements to the one or more stent connector elements.[0011]
• Both the connector members and the stents may be formed of a serpentine ring having one or more apices. One embodiment includes a graft having single stage distal and/or proximal stents in which the associated connector member may have twice as many apices as the stent. In another embodiment, the graft has two-stage distal and/or proximal stents with twice as many apices in a first region as in a second region while the associated connector member has the twice the number of apices as in the first region of the stent. For example, a useful embodiment is one in which a twelve-apex connector member is connected to a first six-apex or six-crown region of a proximal or distal stent and that stent has a second three-apex or three-crown region integral with or joined to the six-crown region.[0012]
• In alternative embodiments, grafts that include various combinations of single and multiple-stage proximal and distal stents with their associated connector members are possible.[0013]
• The stents may also include one or more barbs. Typically, the barbs on a proximal stent are oriented distally to engage the stent into the tissue wall in the proximal-to-distal flow field in which the graft is typically disposed. Likewise, in applications in which the graft is deployed to treat an abdominal or thoracic aortic aneurysm, the barbs on one or more distal stents are typically oriented proximally to engage the stent into the tissue wall to oppose the typically retrograde migration forces. The barbs may range in length from about 1 to about 5 mm. They will typically project radially outward from a longitudinal axis of their respective stent and form a barb radial angle from about 10 to about 45 degrees with respect to the graft proximal neck portion inlet axis when the stent is deployed in vivo. The barbs may also be laterally biased in a plane that is orthogonal to a plane in which the barb radial angle is formed to form a barb kick angle.[0014]
• The stent or stents (proximal and/or distal) comprise struts having one or more optional barb tuck pads integral to the struts such that when the proximal stent is in a reduced profile delivery configuration, each barb is retained by the stent strut. When the endovascular graft is in a deployed configuration, the one or more barbs are released.[0015]
• The stent or stents may also comprise optional barb tuck slots configured to receive the barbs such that each barb is retained by a slot when the stent is in a delivery configuration. In a deployed configuration, the barbs are released from their corresponding barb tuck slots.[0016]
• In addition, the stent may comprise grooves. In a typical delivery system, some type of belts or sutures may be used to help retain the endovascular graft in its compressed delivery configuration. The grooves may accommodate these belts or sutures without increasing the small diameter delivery of the device.[0017]
• The graft body section may also have one or more inflatable cuffs disposed on or near the graft body section proximal end, distal end, or both. The inflatable cuffs provide a sufficiently stiff structure when inflated which help to support the graft body section and provide a conformable surface to seal the graft against the interior surface of the vessel in which it is deployed.[0018]
• The graft body section may also include one or more inflatable channels. The channel or channels typically may be disposed between and in fluid communication with either or both proximal and distal inflatable cuffs. The channel or channels enhance the graft body section stiffness upon their inflation, help to prevent kinking of the graft body section, and may also facilitate deployment of the graft within a patient's body passageway. The inflatable channel or channels can be in a longitudinal and/or linear configuration with respect to the graft body section, but alternatively may take on a helical or circumferential configuration. Other orientations such as interconnecting grids or rings may also be suitable alone or in combination with any of the other configurations.[0019]
• During deployment of the graft, the inflatable cuff or cuffs and channel or channels may be inflated or injected with a material that may comprise one or more of a solid, fluid (gas and/or liquid), gel or other medium. According to the invention, a useful inflation medium includes the combination polyethylene glycol diacrylate, pentaerthyritol tetra 3(mercaptopropionate) and a buffer such as glycylglycine or triethanolamine in phosphate-buffered saline. Saline or another inert biocompatible liquid may be added to this three-component inflation medium in amounts up to about sixty percent of the total inflation medium volume. Radiopaque materials such as tantalum, iodinated contrast agents, barium sulfate, etc. may be added to this three-component medium, typically in the buffer, so to render the inflation medium visible under fluoroscopy.[0020]
• In another embodiment of the invention, the graft may comprise a main body portion and a first bifurcated portion forming a continuous lumen that is configured to confine a flow of fluid therethrough. The graft may also include a second bifurcated portion in fluid communication with the main body portion. At least one inflatable cuff may be disposed at either or both a proximal end of the main body portion and a distal end of the first bifurcated portion. One or more inflatable channels may be disposed between the inflatable cuffs as previously described, and may extend over some or all of the main body portion. The cuffs and channels may be filled with an inflation medium, optionally diluted with an inert biocompatible material such as saline or other liquid, as described above.[0021]
• In yet another embodiment of the invention, the graft may comprise a main body portion in fluid communication with a first and a second bifurcated portion forming a continuous bifurcated lumen, said lumen configured to confine a flow of fluid therethrough. At least one inflatable cuff may be disposed at or near either or both a proximal end of the main body portion and a distal end of the first and second bifurcated portions. One or more inflatable channels may be disposed between the inflatable cuffs as previously described, and may extend over some or all of the main body portion.[0022]
• The proximal ends of the graft main body portion may have connector members comprising one or more connector elements, and a proximal stent coupled to the one or more connector elements. One or both of the first and/or second bifurcated portions may likewise have first and/or second distal connector members comprising one or more connector elements disposed on their respective distal ends, and a distal stent coupled to the first and/or second distal connector members.[0023]
• The present invention is also a system for implanting a tubular medical device within a body lumen having a wall, including a stent for affixing the medical device to the body lumen wall and a connector member for coupling the stent to the medical device, wherein the stent and the connector member are coupled to one another by at least one set of connector elements.[0024]
• One or more barbs may also be included in this system. In addition, one or more barb tuck pads may be included in which the one or more barbs are configured to be retained by the one or more barb tuck pads when the system is in a delivery configuration and released by the one or more barb tuck pads when the system moves to a deployed configuration. The stent may further include optional slots configured to receive the barbs when the system is in a delivery configuration and wherein the barbs are configured to be released from the slots when the system is in a deployed configuration.[0025]
• The invention also includes an endovascular graft comprising a graft body section with a proximal end and a distal end and a proximal connector member affixed to the proximal end of the graft body section. The proximal connector member may have one or more connector elements.[0026]
• The graft may also have a proximal stent comprising one or more distally oriented barbs and one or more proximal stent connector elements coupled to the one or more proximal connector member connector elements and a distal connector member affixed to the distal end of the graft body section. The distal connector member may include one or more connector elements.[0027]
• The graft of this embodiment further includes a distal stent comprising one or more proximally oriented barbs and comprising one or more distal stent connector elements coupled to the one or more distal connector member connector elements, one or more inflatable cuffs disposed at or near each of the proximal and distal ends of the graft body section, and wherein the graft body section comprises an inflatable channel in fluid communication with the proximal and distal cuffs.[0028]
• In addition, the proximal and distal connector member connector elements may each have opposing shoulder portions on their proximal and distal ends, as may the proximal and distal stent connector elements. One or more coupling members may couple the proximal connector member connector elements to the proximal stent connector elements and likewise couple the one or more distal connector member connector elements to the one or more distal stent connector elements.[0029]
• At least one of the inflatable channel, the distal inflatable cuff, and the proximal inflatable cuff may contain an inflation medium comprising the combination polyethylene glycol diacrylate, pentaerthyritol tetra 3(mercaptopropionate), and a buffer.[0030]
• The proximal stent barbs or distal stent barbs of this embodiment may have a length from about 1 to about 5 mm, and the graft body section may comprise ePTFE.[0031]
• In yet still a further bifurcated embodiment of the present invention, the device includes a main body portion with a distal end and a proximal end with a connector member disposed on the proximal end. The connector member may include one or more connector elements.[0032]
• The proximal stent of this embodiment may comprise one or more distally oriented barbs and one or more proximal stent connector elements that are coupled to the connector member connector elements.[0033]
• This embodiment further includes a first bifurcated portion and a second bifurcated portion forming a continuous lumen with the main body portion. This lumen is configured to confine a flow of fluid therethrough.[0034]
• A distal connector member may be disposed on distal ends of each of the first and second bifurcated portions. Each of these distal connector members includes one or more connector elements. In addition, this embodiment has one or more distal stents with at least one proximally oriented barb and comprising one or more distal stent connector elements. The distal stent connector elements are coupled to the distal connector member connector elements on one or both of the first and second bifurcated portions.[0035]
• This embodiment also includes at least one inflatable channel extending from one or both of the first and second bifurcated portions to the main body portion, at least one inflatable cuff disposed at or near a proximal end of the main body portion in fluid communication with the at least one channel, and an inflatable cuff disposed at or near a distal end of each of the first and second bifurcated portions.[0036]
• The proximal and distal connector member connector elements may each have opposing shoulder portions on their proximal and distal ends, as may the proximal and distal stent connector elements. One or more coupling members may couple the proximal connector member connector elements to the proximal stent connector elements and likewise couple the one or more distal connector member connector elements to the one or more distal stent connector elements.[0037]
• At least one of the inflatable channel, the first bifurcated portion distal inflatable cuff, the second bifurcated portion distal inflatable cuff, and the proximal inflatable cuff may contain an inflation medium comprising the combination polyethylene glycol diacrylate, pentaerthyritol tetra 3(mercaptopropionate), and a buffer.[0038]
• The proximal and/or distal stent barbs may have a length from about 1 to about 5 mm. The graft main body portion as well as the first and second bifurcated portions may comprise ePTFE.[0039]
• These and other advantages of the invention will become more apparent from the following detailed description of the invention when taken in conjunction with the accompanying exemplary drawings.[0040]
BRIEF DESCRIPTION OF THE DRAWINGS
• FIG. 1 shows an endovascular graft according to an embodiment of the present invention.[0041]
• FIGS.[0042]1A-1B detail two angles at which a stent barb may be oriented on the graft of an embodiment of the present invention.
• FIG. 2 shows a second endovascular graft according to an embodiment of the present invention.[0043]
• FIG. 3 shows a flat pattern of a component of the endovascular graft of FIG. 2.[0044]
• FIG. 4 shows a flat pattern of another component of the endovascular graft of FIG. 2.[0045]
• FIG. 5 shows a flat pattern of a portion of the endovascular graft of FIG. 2.[0046]
• FIG. 5A is an enlarged side view of FIG. 5 at Detail A.[0047]
• FIG. 6 is an enlarged view of a portion of an endovascular graft having features of an embodiment of the present invention.[0048]
• FIG. 7 shows a bifurcated endovascular graft according to embodiments of the present invention.[0049]
• FIG. 8 shows a flat pattern of yet another component of the endovascular graft of FIG. 2.[0050]
• FIG. 9 shows a flat pattern of another component of the endovascular graft of FIG. 2.[0051]
• FIG. 10 shows detail of a stent apex detail that comprises offset circular and elliptical radii.[0052]
• FIG. 11 shows detail of a stent apex detail that comprises offset circular radii.[0053]
• FIG. 12 shows detail of a stent section comprising a tapered strut section.[0054]
• FIG. 13 shows detail of a stent section comprising another configuration for a tapered strut section.[0055]
DETAILED DESCRIPTION
• FIG. 1 shows an[0056]endovascular graft10 in its deployed configuration. Unless otherwise stated, the term “graft” or “endovascular graft” is used herein to refer to a prosthesis capable of repairing and/or replacing diseased vessels or portions thereof, including generally tubular and bifurcated devices and any components attached or integral thereto. For purposes of illustration, the graft embodiments described below are assumed to be most useful in the endovascular treatment of abdominal aortic aneurysms (AAA). For the purposes of this application, with reference to endovascular graft devices, the term “proximal” describes the end of the graft that will be oriented towards the oncoming flow of bodily fluid, typically shows a flat pattern blood, when the device is deployed within a body passageway. The term “distal” therefore describes the graft end opposite the proximal end. Finally, while the drawings in the various figures are accurate representations of the various embodiments of the present invention, the proportions of the various components thereof are not necessarily shown to exact scale within and among or between any given figure(s).
• [0057]Graft10 has aproximal end11 and adistal end12 and includes a generally tubular structure orgraft body section13 comprised of one or more layers of fusible material, such as expanded polytetrafluoroethylene (ePTFE). A proximalinflatable cuff16 is disposed at or near aproximal end14 ofgraft body section13 and an optional distalinflatable cuff17 is disposed at or near a graft body sectiondistal end15.Graft body section13 forms alongitudinal lumen22 configured to confine a flow of fluid therethrough and may range in length from about 5 to about 30 cm; specifically from about 10 to about 20 cm.
• As will be described in greater detail below, inflation of[0058]cuffs16 and17 will cause them to assume a generally annular shape (especially whengraft body section13 is in an unconstrained state).Inflatable cuffs16 and17 will generally, however, conform to the shape of the vessel within which it is deployed. When fully inflated, cuffs16 and17 may have an outside diameter ranging from about 10 to about 45 mm; specifically from about 16 to about 32 mm.
• At least one[0059]inflatable channel18 may be disposed between and in fluid communication with proximalinflatable cuff16 and distalinflatable cuff17.Inflatable channel18 provides structural support to graftbody section13 when inflated to contain an inflation medium.Inflatable channel18 further prevents kinking and twisting of the tubular structure or graft body section when it is deployed within angled or tortuous anatomies as well as during remodeling of body passageways (such as the aorta and iliac arteries) within whichgraft10 is deployed. Together with proximal anddistal cuffs16 and17,inflatable channel18 forms a network of inflatable cuffs and channels in fluid communication with one other.
• We have found the helical configuration of[0060]channel18 in the FIG. 1 embodiment to be particularly effective in providing the needed kink resistance for effectively treating diseased body passageways such as AAAs, in which highly angled and tortuous anatomies are frequently found. In alternative embodiments, however, other cuff and channel configurations are possible.Inflatable channel18 may be disposed helically as shown in FIG. 1, it may take on a more circumferential or annular rib and spine configuration as shown in the FIG. 2 embodiment, or otherwise. Similarly, the longitudinal and radial dimensions ofinflatable channel18 may vary as necessary both between different graft body sections and even within a single graft body section, depending on the indication for whichgraft10 is intended to treat. Further,inflatable channel18 may be oriented at various angles with respect to thelongitudinal axis25 ofgraft body section13, and the pitch (the distance between helical or parallel windings of channel18) may vary as necessary.
• In the embodiment of FIG. 1, the channel pitch, or distance between each helical[0061]inflatable channel18 winding, may range from about 2 to about 20 mm, depending on the overall size ofgraft body section13 and the desired degree of kink resistance. We have found that a pitch of between about 4 and about 10 mm is effective for tubular embodiments of the present invention and a pitch of between about 3 and about 10 mm to be useful in bifurcated graft embodiments. The helix angle of each channel winding (measured with respect to a plane perpendicular to the graft body section longitudinal axis25) may range from about 10 to about 45 degrees; more specifically, from about 20 to about 35 degrees in tubular and bifurcated graft embodiments. Finally, the width ofinflatable channel18 typically ranges from about 1 to about 8 mm; more specifically, from about 2 to about 4 mm.
• Graft body section or[0062]tubular structure13 and its associated components may be made from a variety of suitable materials, including ultra high molecular weight polyethylene, polyesters, and the like. As previously discussed, we have found constructinggraft body section13 primarily from one or more layers of ePTFE to be particularly useful. Details of howgraft10 may be fabricated (as well as all of the other grafts discussed herein) are more fully described in parent U.S. patent application Ser. No. 10/029,559 and in copending U.S. patent application Ser. Nos. 10/029,570, 10/029,584, and 10/029,557, each to Chobotov et al. In addition, U.S. patent application Ser. No. 09/133,978 to Chobotov, filed Feb. 9, 1998 and entitled “Endovascular Graft” and copending U.S. patent application Ser. No. 09/917,371 to Chobotov et al., filed Jul. 27, 2001 and entitled “Bifurcated Stent-Graft Delivery System and Method,” the entirety of each of which is hereby incorporated herein by reference, teach a useful endovascular stent-graft and delivery system, respectively.
• A[0063]proximal neck portion23 is disposed in the vicinity of graft body sectionproximal end14 and serves as an additional means to help seal the deployed graft against the inside of a body passageway.Proximal neck portion23 has aninlet axis27 that forms an inlet axis angle α in relation to graft body sectionlongitudinal axis25. Thisangled inlet axis27 allows the graft to better conform to the morphology of a patient's vasculature in patients who have an angled vessel morphology, such as is often the case in the neck region of abdominal aortic aneurysms. The inlet axis angle α may range in any direction with respect tolongitudinal axis25 from about zero to about 90 degrees, preferably from about 20 to about 30 degrees.Proximal neck portion23 may be tapered or flared to a larger diameter in the proximal direction to facilitate this sealing function.Proximal neck portion23 also serves as a means of providing a smooth fluid flow transition intograft lumen22.
• The network of[0064]inflatable cuffs16,17 andchannel18 may be inflated, most usefully in vivo, by introduction or injection of a material or medium through aninjection port33 that is in fluid communication withcuff17 and the associated cuff/channel network. The material may comprise one or more of a solid, fluid (gas and/or liquid), gel or other medium. The material may contain a contrast medium that facilitates imaging the device while it is being deployed within a patient's body. For example, radiopaque materials containing elements such as bismuth, barium, gold, iodine, platinum, tantalum or the like may be used in particulate, liquid, powder or other suitable form as part of the inflation medium. Liquid iodinated contrast agents are a particularly suitable material to facilitate such imaging. Radiopaque markers may also be disposed on or integrally formed into or on any portion ofgraft10 for the same purpose, and may be made from any combination of biocompatible radiopaque materials.
• A[0065]connector member24 is affixed to or integrally formed ingraft body section13, or as shown in FIG. 1, at or near graft body sectionproximal end14 andproximal neck portion23.Connector member24 is a serpentine ringstructure comprising apices28.Connector member24 may be made from any suitable material that permits expansion from a constrained state, most usefully a shape memory alloy having superelastic properties such as nickel titanium (NiTi). Othersuitable connector member24 materials include stainless steel, nickel-cobalt alloys such as MP35N, tantalum and its alloys, polymeric materials, composites, and the like. Connector member24 (as well as all stents and connector members described herein) may be configured to self-expand from a radially constrained state or be configured to expand as a result of an applied force (such as from an inflated balloon), or, in the case of some shape memory materials, a temperature change.
• The configuration of[0066]connector member24 shown in FIG. 1 comprises eight apices28 (put more precisely, the FIG. 1connector member24 comprises eight proximal apices and eight distal apices; however, unless otherwise mentioned, the term “apices” refers in this context to either the proximal or distal set of apices in a single connector member, stent, or stent portion). Another particularly useful configuration is one shown in FIGS.2-7 in which the connector member comprises twelve apices. Any number of apices up to twenty-four or more may be used inconnector member24. In general terms, as the number ofapices28 onconnector member24 increase,connector member24 will exhibit a greater conformability to the vessel wall when it is expanded from a radially constrained state.
• No matter the number of apices present, one function of[0067]connector member24 is to work in conjunction withproximal neck23 in which it is typically embedded to help seal the deployed graft against the inside of a body passageway as previously described. It can also play a role in helping to keepgraft10 in place within the vessel wall and may also facilitate the opening of graft body sectionproximal end14 during deployment.
• Some[0068]apices28 may also comprise a connectormember connector element30, described more fully below with respect to the embodiment of FIG. 2. In the FIG. 1 embodiment, in whichconnector member24 comprises eight (proximal)apices28, aconnector element30 is distributed on everyother apex28. We have found this configuration to be suitable for meeting the various performance requirements of the present invention. Other configurations are possible, including the twelve-apex connector member24 shown in FIGS.2-7 comprising sixconnector elements30 distributed on everyother apex28. Other configurations in which, for example, connector elements are distributed on every apex, every third or fourth apex, or any other pattern are within the scope of the present invention.
• [0069]Graft10 further comprises aproximal stent40 having aproximal end42 and adistal end44. Although other configurations are possible,proximal stent40 in the FIG. 1 embodiment comprises a serpentine ring having fourapices46, or half the number ofapices28 ofconnector member24. Note thatproximal stent40 in FIG. 1 takes on an optional tulip-shaped tapered profile in which the stent's diameter varies along its length. Such a profile serves to present sufficient radial force upon radial expansion ofstent40 to reliably anchorgraft10 to the vessel or lumen wall within which it is deployed while, at its tapered distal end neargraft body section13, refraining from interfering with the sealing function performed byproximal cuff16,proximal neck portion23, andconnector member24. This profile also accommodates any taper that may be present in the host vessel or lumen.
• As shown in FIG. 1,[0070]proximal stent40 is disposed generally proximal tograft body section13 andconnector member24. Proximal stent is typically, though not necessarily, made a part ofgraft10 by being affixed or connected toconnector member24 via connector elements as described in detail below.Proximal stent40 may also be affixed or embedded directly to or inproximal neck portion23 and/or other portions ofgraft body section13. In addition, the present invention includes embodiments wherein the connector member and proximal stent are not mechanically or otherwise fastened to one another but rather unified, formed of a monolithic piece of material such as NiTi.
• This configuration of[0071]proximal stent40,connector member24,proximal neck portion23, andproximal cuff16 helps to separate the sealing function ofproximal cuff16, which requires conformation and apposition to the vessel wall within whichgraft10 is deployed without excessive radial force, from the anchoring function of proximal stent40 (connector member24 andproximal neck portion23 play intermediate roles). This allows the sealing and anchoring functions each to be optimized without compromising the other. In addition, in part becauseproximal stent40,connector member24, andinflatable cuff16 are longitudinally distributed along the graft body sectionlongitudinal axis25, a smaller, more flexible delivery profile ranging from about 10 to about 16 French is possible; preferably below 12 French.
• [0072]Proximal stent40 may be manufactured from any of the materials suitable forconnector member24. When manufactured from a shape memory alloy having superelastic properties such as NiTi,proximal stent40 may be configured to self-expand upon release from a constrained state.
• [0073]Proximal stent40 further comprises proximalstent connector elements48 that are affixed to connectormember connector elements30 via coupling members as described more fully below in relation to FIGS.2-6. Note that in the FIG. 1 embodiment, there is one proximalstent connector element48 for every connectormember connector element30.
• [0074]Proximal stent40 also comprisesstruts41 and may also comprise one ormore barbs43. A barb can be any outwardly directed protuberance, typically terminating in a sharp point that is capable of at least partially penetrating a body passageway in whichgraft10 is deployed (typically the intimal and medial layers of a blood vessel such as the abdominal aorta).
• When[0075]proximal stent40 is deployed in the abdominal aorta, for example, typically in a location proximal to the aneurysm and any diseased tissue,barbs43 are designed to work in conjunction with the distally-oriented blood flow field in this location to penetrate tissue and prevent axial migration ofgraft10. This is whybarbs43 in the FIG. 1 embodiment are oriented distally with respect to graftbody section13.
• In alternative embodiments, depending upon the material used in the manufacture of[0076]proximal stent40, the clinical demands and other factors, the degree to whichbarbs43 help maintain the position ofgraft10 within the vessel may vary. Consequently, the number, dimensions, configuration and orientation ofbarbs43 may vary significantly, yet be within the scope of the present invention.
• The length of[0077]barbs43 in any of the embodiments of the present invention may range from about 1 to about 5 mm; more particularly, from about 2 to about 4 mm.
• As shown in their free expanded configuration in FIG. 1 and as shown in greater detail in FIG. 1A,[0078]barbs43 may be oriented in a distal direction and form an elevation angle β ranging from about 10 to about 45 degrees or higher with respect to alongitudinal axis29 ofstrut41, projecting generally radially outward fromgraft lumen22 away from proximalneck inlet axis27. Disposing barbs at angle β provides the necessary embedding force to anchorgraft10 into the vessel or lumen in which it is deployed. Although not shown in the figures, the barb elevation may also be described when thegraft10 is deployed in vivo in a body lumen or vessel by a second angle β′ measured relative to proximalneck inlet axis27. This second barb elevation angle β′ will typically range from about 5 to about 45 degrees. For both barb elevation angles β and □β′, similar orientations may be found with barbs in other embodiments of the present invention.
• It is generally desirable that[0079]barbs43 be oriented in a position generally parallel to the axis of the lumen in which they are deployed so that they are in a position to best resist the drag loads imposed by the flow field in vivo in certain applications. To this end, we have found it useful for one or more ofbarbs43 to form an optional second barb azimuth or “kick” angle γ with respect to strutlongitudinal axis29 as shown in FIG. 1B. In this view,barb43 is laterally biased in a plane that is tangent to anoutside surface37 ofstrut41 and generally orthogonal to a plane in which angle γ is formed. The term “strut outsidesurface37” generally refers to that portion of the surface ofstrut41 located opposite the proximalneck inlet axis27, or that portion ofstrut41 that when deployed will be in direct contact with the vessel or lumen wall. We have also found that providing lateral kick angle γ tobarbs43 contributes to greater barb stability when the barb is tucked behind an adjacent strut or tuck pad in a reduced diameter delivery configuration. Inproximal stent40, γ may range from between about 5 and about 70 degrees relative to strutaxis41. Similar orientations may be found with barbs in other embodiments of the present invention.
• The number of barbs, the length of each barb, each of the barb angles described above, and the barb orientation may vary from barb to barb within a single stent or between multiple stents within a single graft.[0080]
• Note that although the various barbs (and tuck pads[0081]45 discussed below) discussed herein may be attached to or fixed on the stent struts41, we have found it useful that, as shown in the various figures, they be integrally formed as part of the stent struts. In other words, they can be mere extensions of the struts in which no joint or other connection exists. Because there is no joint, we have found the strength of the barb/strut interface to be very high, as is the fatigue resistance of the barbs. With no mechanical connection to join the barbs to the struts, reliability of the barb/strut interface is higher. In addition, the lack of a heat-affected zone in which the mechanical properties of a welded or brazed joint may be deleteriously affected is another significant advantage to having the barbs and tuck pads be integral to the stent.
• [0082]Struts41 may also comprise optional integral tuck pads45 disposed opposite eachbarb43. As is the case with the barbs, the number, dimensions, configuration and orientation of barb tuck pads45 may vary significantly.
• During preparation of graft[0083]10 (and therefore proximal stent40) into its reduced diameter delivery configuration, eachbarb43 is placed behind a corresponding strut41 (and optional tuck pad45, if present) so to thereby prevent that barb from contacting the inside of a delivery sheath or catheter during delivery of the device and from undesired contact with the inside of a vessel wall. As described in copending U.S. patent application Ser. No. 09/917,371 to Chobotov et al., a release belt disposed in one or more grooves35 disposed onstruts41 retainproximal stent40 in this delivery configuration.
• Upon deployment of[0084]graft10, and more particularly,proximal stent40, (typically accomplished in part by release of this and other belts), the radial expansion ofstent40 results in a displacement ofstruts41 so that the distance between them increases. Eventually this displacement becomes large enough so to free the barbs from behind the adjacent strut (and optional tuck pad45, if present) and engage the wall of the lumen being treated. During experiments in which stents of the present invention having barbs described herein are released from a constrained delivery configuration to assume an expanded or deployed configuration, high speed video confirms that the barbs tend to release with a time constant that is generally an order of magnitude lower than the time constant associated with the radial expansion of the stent. In other words, during the stent deployment process, their barbs complete their deployment before the stent is fully expanded, so that the barbs may engage the vessel or lumen wall with maximum effectiveness.
• Alternatively, and especially in the case when a different material such as stainless steel is used for[0085]proximal stent40, an optional balloon may be used to expandstent40 tofree barbs43 from their tuck pads45 and to causebarbs43 to engage tissue as desired. Even if a superelastic self-expandingproximal stent40 is used ingraft10, such a balloon may be used to help further implantbarbs43 into their desired position to ensure proper placement ofgraft10.
• Turning now to FIG. 2, another endovascular graft having features of the present invention is illustrated.[0086]Graft50 has aproximal end51 and adistal end52 and comprises a tubular structure orgraft body section53 with aproximal end54 anddistal end55. As with the FIG. 1 embodiment,graft body section53 forms alongitudinal lumen73 configured to confine a flow of fluid therethrough and may range in length from about 5 to about 30 cm; specifically from about 10 to about 20 cm. Proximalinflatable cuff56 and optional distalinflatable cuff57 form a seal when inflated to help prevent transmission of pressure (hemodynamic pressure when the fluid is blood) to the lumen or vessel walls in the region between the proximal and distal cuffs. In addition, the cuffs help to prevent flow of fluid such as blood around the outer surface ofgraft body section53.
• [0087]Inflatable channel58 comprises an inflatable longitudinal channel or spine in fluid communication with a series of approximately parallel inflatable circumferential channels or ribs. We have found this configuration to be particularly useful in providing effective kink resistance while allowing for rapid and relatively easy inflation of the cuffs and channels when using more viscous inflation materials.Channel58 is in fluid communication with proximal anddistal cuffs56 and57, forming a network of inflatable cuffs and channels in fluid communication with each other. Fillport59 is in fluid communication withdistal cuff57,inflatable channel58, andproximal cuff56, adding to this network for the introduction of an inflation medium intograft body section53. Features of the FIG. 1 embodiment not discussed herein may be present in the FIG. 2 device.
• [0088]Graft50 of FIG. 2 also comprises a twelve-crown or twelve-apexproximal connector member60, a two-stage six- and three-crownproximal stent70,distal neck portion77,distal connector member124, anddistal stent128.Distal connector member124 anddistal stent128 are analogous toconnector member60 andproximal stent70 except that the distal stent in the FIG. 2 embodiment is single-stage and its optional barbs face in the opposite, or proximal direction relative to thebarbs74 ofproximal stent70.Distal connector member124 is affixed or attached todistal stent128, both of which are more fully described in relation to a bifurcated version of the present invention shown in FIGS. 8 and 9, respectively.Distal connector member124 anddistal stent128 may be manufactured from materials and according to methods that are suitable forconnector member60 andproximal stent70. Further,distal connector member124 may be attached to, affixed to, formed integrally with tubular structure orgraft body section53, or more typically,distal neck portion77.Distal connector member124 further comprises fillport bridge132.
• FIG. 3 shows a detailed flat pattern view of the[0089]proximal connector member60 shown in FIG. 2.Proximal connector member60 comprises adistal end66 and aproximal end64 having twelve crowns orapices65. Alternateproximal apices65 comprise proximal connectormember connector elements62. Theseconnector elements62 each in turn comprises aproximal end61, adistal end63, andoptional ears80 disposed neardistal end63.Ears80 provide for increased surface area onconnector elements62 to aid in maximizing the strength of the bond between connector element and graft proximal neck portion and further comprises one or moreoptional apertures82 to farther enhance such a bond as previously discussed. Opposingshoulder portions84 may have rounded corners so to minimize their potential to snag, tear, or otherwise interfere with other components of the graft or the lumen in which it is deployed.Shoulder portions84 also have one or more optional shoulder holes85. These shoulder holes85 are useful in helping to stabilize theproximal stent70 andproximal connector member60 device as they are coupled during assembly as discussed below in conjunction with FIG. 5A.
• As illustrated in FIGS.[0090]4-5 and6-7, two-stageproximal stent70 has aproximal end76 and adistal end77 with proximalstent connector elements72. Proximalstent connector elements72 have opposingshoulder portions78 that may mirror opposingshoulder portions84 of distalstent connector elements62.
• [0091]Proximal stent70 comprisesstruts71, any one of which may further comprise one ormore barbs74. Optionalbarb tuck pads86 near each barb serve to shieldbarbs74 whengraft50 is in its reduced diameter delivery configuration.Struts71 ortuck pads86 may also contain an optionalbarb tuck slot85 to help retainbarbs74 while graft50 (and consequently proximal stent70) is in its delivery configuration. Upon deployment ofgraft50 as previously described with respect to the FIG. 1 embodiment,barbs74 are released frombarb tuck slots85 and are placed in their operational, or deployed configuration, as shown in FIGS. 2 and 6. When so deployed in a patient vessel,proximal stent70 is expanded, forcingbarbs74 at least partially into the vessel wall to emplacegraft50 therein and to resist fluid flow forces that might otherwise dislodgegraft50.
• [0092]Proximal stent70 also may comprise one or more sets ofoptional grooves87 for housing device release bands as previously discussed.
• Unlike[0093]proximal stent40 of FIG. 1, however,proximal stent70 is a two-stage component having a first, or six-crown region90 and a second, or three-crown region92. The first, or six-crown region90 comprises a serpentine ring having six apices94 (i.e., six distal and six proximal apices). Likewise, the second, or three-crown region92 comprises a serpentine ring having threeapices93, the distal apices of which connect to every otherproximal apex94 of six-crown region90. Note thatproximal stent70 is typically made from a single piece of material such that there are no joints or connections between each stage (such as a mechanical connection or a weld, etc.). However, other configurations in which two or more stages may be so joined or connected from separate parts or stents to form a single stent are possible; likewise, single-piece stents having more than two stages are also possible.
• [0094]Proximal stent70 may exhibit a greater outward radial force at three-crown region92 than in six-crown region90. Such a design is particularly useful in a clinical setting in which it is desired that such outward radial force be applied within a healthier section of vessel, more remote from the site of disease.Proximal stent70 may accordingly perform the anchoring function within a portion of vessel that can accommodate such radial force.
• FIG. 5 is a flat pattern view of[0095]connector member60 joined toproximal stent70. For this embodiment, there is a relationship among thevarious apices65,93 and94 of theconnector member60 and the two stages ofproximal stent70, respectively, in which there are twelveconnector member apices65, sixapices94 in the proximal stent first or six-crown region90 and threeapices93 in the proximal stent second or three-crown region92.
• While the actual number of apices may vary as previously discussed, this more generally illustrates a useful convention for the present invention in which the relationship among the various apices may be described: for instance, if the number of[0096]connector member60apices65 is denoted “n”, “n/2” then denotes the number ofproximal stent70 first or six-crown region90apices94 and “n/4” as the number ofproximal stent70 second or three-crown region92apices93. Other useful embodiments include those in which there are “n” connector member apices, “n” proximal stent first region apices, and “n/2” proximal stent second region apices. These ratios may vary as appropriate; these particular sets of ratios are merely illustrative.
• Note also in FIG. 5 that connector[0097]member connector elements62 are coupled to proximalstent connector elements72 viacoupling members54.
• FIG. 5A is a side view of proximal[0098]stent connector element72, connectormember connector element62, andcoupling member54. Couplingmember54 is a wire or similar element wrapped to form a coil around the overlapping connectormember connector element62 and proximalstent connector element72 to mechanically joinconnector member60 toproximal stent70. Alternatively, any other suitable joining technique, such as welding, brazing, soldering, mechanical means, adhesive, etc. may be used to join these components of thegraft50. We have found, however, that mechanical means such ascoupling member54 is most useful in that it avoids problems presented by techniques such as welding, etc., where possible heat-affected zones some distance from the joint may deleteriously affect the microstructure of the stent/connector element material, especially when that material is nickel titanium, thus having a negative impact on the joint strength, fatigue life, and ultimately the integrity ofgraft50.
• Any suitable member may be used for coupling[0099]member54 although we have found a wire or wire-like member having a circular cross-sectional shape to be useful (although any shape may be used). Optimally, thewire coupling member54 may be formed of a suitable metal such as nickel, stainless steel, nickel-titanium, etc. The wire may have a diameter ranging from about 0.002 to about 0.006 inch; more specifically from about 0.003 to about 0.005 inch.
• To secure the[0100]connector elements62 and72 to one another,coupling member54 may be wound around the matched connector elements one or more times. We have found that providing enough windings to present a single layer of wire in which the windings are immediately adjacent one another fromshoulder78,84 toshoulder78,84 provides sufficient strength and stiffness to the joint thus created without detracting from the low delivery profile afforded by the novel design ofgraft50. Thus the number of optimal windings from graft to graft will vary but typically ranges from about 6 to about 18 windings in most applications. Withcoupling members54 in place, connectormember connector elements62 and proximalstent connector elements72 are securely coupled to one another. The features and advantages ofcoupling member54 discussed herein may be utilized by any of the embodiments of the present invention herein discussed.
• FIG. 6 is a perspective view of[0101]connector member60 joined toproximal stent70 in this way in their expanded, or deployed configuration.Graft body section53 and other graft components are removed for clarity of illustration.Barbs74 are shown in their deployed state, released from optionalbarb tuck pads86.
• FIG. 7 illustrates another embodiment of the invention in the form of a bifurcated[0102]endovascular graft100. A bifurcated device such asendovascular graft100 may be utilized to repair a diseased lumen at or near a bifurcation within the vessel, such as, for example, in the case of an abdominal aortic aneurysm in which the aneurysm to be treated may extend into the anatomical bifurcation or even into one or both of the iliac arteries distal to the bifurcation. In the following discussion, the various features of the graft embodiments previously discussed may be used as necessary in thebifurcated graft100 embodiment unless specifically mentioned otherwise.
• [0103]Graft100 comprises a firstbifurcated portion114, a secondbifurcated portion115 andmain body portion116. The size and angular orientation of thebifurcated portions114 and115, respectively, may vary even betweenportion114 and115—to accommodate graft delivery system requirements and various clinical demands. For instance, each bifurcated portion or leg is shown in FIG. 7 to have a different length, but this is not necessary. First and secondbifurcated portions114 and115 are generally configured to have an outer inflated diameter that is compatible with the inner diameter of a patient's iliac arteries. First and secondbifurcated portions114 and115 may also be formed in a curved shape to better accommodate curved and even tortuous anatomies in some applications.
• Together,[0104]main body portion116 and first and secondbifurcated portions114,115 form a continuous bifurcated lumen, similar tolumens22 and73, which is configured to confine a flow of fluid therethrough. And although not shown in FIG. 7,graft100 does not have to have a secondbifurcated portion115, in which case the bifurcated lumen is formed betweenmain body portion116 and firstbifurcated portion114.
• First and second[0105]bifurcated portions114 and115 each comprises a network of inflatable cuffs and channels as discussed with respect to the FIG. 2 embodiment, includinginflatable channel113.Channel113 comprises one or more optional inflatablelongitudinal channels110 in fluid communication with one or more approximately parallel inflatablecircumferential channels144, all of which are in fluid communication with optional distalinflatable cuffs117 and119.
• As with the embodiments previously discussed, the number of inflatable[0106]circumferential channels144 may vary with the specific configuration of the graft as adapted to a given indication. Generally, however, the number of inflatablecircumferential channels144 per bifurcated portion may range from 1 to about 30, preferably about 10 to about 20. Similarly, the dimensions, spacing, angular orientation, etc. of circumferentialinflatable channels144 may vary as well.
• For instance, the distance between and width of each circumferential[0107]inflatable channel144 may vary along the length of the graft or may be constant. The pitch or inter-ring distance may range from about 2 to about 20 mm; specifically, it may range from about 3 to about 10 mm. Circumferentialinflatable channels144 are each typically between about 2 and about 4 mm wide, but may be from about 1 to about 8 mm wide. Eachlongitudinal channel110 is typically from about 2 to about 4 mm wide, but may vary, together or independently, to be from about 1 to about 8 mm wide.
• In the embodiment of FIG. 7,[0108]channel113 forms a continuous cuff and channel network extending from firstbifurcated portion114 tomain body portion116 to secondbifurcated portion115. Accordingly,inflatable channel113 fluidly connects into a network with proximalinflatable cuff111, secondaryproximal cuff112, circumferentialinflatable channels144, optional distalinflatable cuff117 and optional distalinflatable cuff119. Note thatlongitudinal channels110 extend proximally alongmain body portion116 to be in fluid communication withcuffs111 and112.
• In alternative embodiments of the graft of FIG. 7 as well as that of FIGS. 1 and 2, numerous other inflatable channel and cuff configurations are possible. The inflatable channel for instance may be disposed longitudinally, horizontally, in a helical fashion, or otherwise. One or more additional cuffs may be disposed on either or both[0109]bifurcated portions114 and115 as well asmain body portion116. In other embodiments,graft100 may have compartmentalized channels and cuffs requiring multiple sites from which they are inflated and may use multiple inflation materials to optimize properties in each region.
• Second[0110]bifurcated portion115 may be of a similar construction to firstbifurcated portion114. In the FIG. 7 embodiment ofgraft100, secondbifurcated portion115 is of a unitary, continuous construction with firstbifurcated portion114 andmain body portion116. Alternatively, first and secondbifurcated portion114 and115 respectively may be singly or jointly formed separately from a main body portion and may be joined to the main body portion before deployment in the body passageway or in vivo after such deployment.
• First and second[0111]bifurcated portions114 and115 may be generally cylindrical in shape when deployed, and will generally conform to the shape of a vessel interior within which they are deployed. Their length as measured frommain body portion116 may range from about 1 to about 10 cm or more. The nominal inflated outside diameter of the distal ends of the first and secondbifurcated portions114 and115 atcuffs117 and119 may range from about 2 to about 30 mm, preferably from about 5 to about 20 mm.
• [0112]Main body portion116 comprises a proximalinflatable cuff111 and an optional secondary proximalinflatable cuff112 in fluid communication with one or more inflatablelongitudinal channels110. As with other embodiments,proximal cuff111 serves primarily to sealgraft100 firmly against a lumen wall. Secondary proximalinflatable cuff112 has been found to confer additional kink resistance ongraft100, particularly in those clinical applications in which the vessel in which the graft is deployed is highly angled or tortuous. The nominal inflated outside diameter of secondary proximalinflatable cuff112 may range from about 10 to about 45 mm, preferably from about 15 to about 30 mm, while the nominal inflated outside diameter ofproximal cuff111 may range from about 10 to about 45 mm, preferably from about 16 to about 32 mm.Main body portion116 may range in length from about 2 to about 10 cm; preferably from about 4 to about 8 cm.
• Endovascular[0113]graft100 further comprises aproximal connector member118,proximal stent120, and proximal neck portion146 all of which may be similar to those components discussed above in reference to FIGS.2-6. Coupling members (not shown) may joinproximal stent120 andproximal connector member118 as discussed with respect to the embodiments of FIGS.1-6. Proximal connector members and proximal stents as discussed in conjunction with the FIG. 1 embodiment are also possible for use inbifurcated graft100.
• In bifurcated embodiments of grafts having features of the invention which also have a biased proximal end that forms an inlet axis angle, the direction of the bias or angulation can be important with regard to achieving a proper fit between the graft and the morphology of the deployment site. Generally, the angular bias of the proximal end of the graft, proximal neck portion or proximal anchor can be in any direction. Preferably, the angular bias is in a direction and of a magnitude consistent with the mean angulation of the type of lesion (e.g. abdominal aortic aneurysm) intended for treatment with the graft.[0114]
• As with[0115]proximal stent70 of the embodiments shown in FIGS. 2 and 4-6,proximal stent120 comprisesbarbs121 which are oriented in a distal direction for reliable anchoring against the direction of pulsatile forces in vivo when the device is implanted in the abdominal aorta, for instance, to treat an abdominal aortic aneurysm.
• One or both[0116]bifurcated portions114 and/or115 may further comprise adistal connector member124 and/or150, adistal stent128, and a distal neck portion154. The embodiment of FIG. 7 hasdistal connector member124 anddistal stent128 disposed at the distal ends of each of first and secondbifurcated portions114 and115, respectively.Distal connector member124 anddistal stent128 are shown in greater detail in FIGS. 8 and 9.
• As discussed with respect to the FIG. 2 embodiment and as shown more clearly in FIG. 8,[0117]distal connector member124 disposed at or near firstbifurcated portion114 comprises distal connectormember connector elements130 and an optional fill-port bridge132. Fill-port bridge132 serves to prevent interference bydistal connector member124 with the manufacture ofgraft100 and with the injection of an inflation medium, while preserving the continuous ring structure ofdistal connector member124.
• Inflatable channels[0118]113 (and other inflatable members of the invention) are in communication with afill port160 through distalinflatable cuff117. Fillport160 may be disposed alternatively on secondbifurcated portion115 or graftmain body portion116, and more than one fill port may be used. Fillport160 is configured to accept a pressurized source of fluid (gas and/or liquid), particles, gel or combination thereof as previously discussed.
• As discussed with respect to the FIG. 2 embodiment, FIG. 9 details a flat pattern of[0119]distal stent128, which includes distalstent connector elements134. Distal connectormember connector elements130 are configured to be coupled with distalstent connector elements134 via coupling members (not shown) similar to those discussed with respect to the FIGS.1-6 embodiments.Distal stent128 comprises one or more optionaldistal stent barbs136, one or more optional distal stentbarb tuck pads138 and one or more optional distal stentbarb tuck slots140, each of which functions in a similar fashion to the corresponding features of embodiments discussed above.Distal stent barbs136 are oriented proximally, opposite the direction of orientation ofbarbs121, to accommodate the environment often found in the iliac arteries that can cause thebifurcated portions114 and115 to migrate proximally in vivo. Note that only twodistal stent barbs136 are shown in FIG. 9 for the purposes of clarity of illustration despite a larger number being depicted in the FIG. 7 embodiment of the present invention. It is understood that all embodiments of the present invention includes proximal and distal stents each of which may optionally comprise one, two, or any number of barbs.
• The optional[0120]distal connector member150, disposed in the FIG. 7 embodiment at or neardistal end152 of secondbifurcated portion115, has a structure similar to that of firstbifurcated portion114, with the exception of the absence of fill-port bridge132. Other embodiments of the invention include bifurcated grafts in which thedistal connector member150 includes a fill-port bridge.
• FIGS.[0121]10-13 illustrate additional features of the present invention that may be used in any of the various stents and connector rings of the present invention, in any combination.
• Turning to FIG. 10, a simplified detail of a[0122]proximal apex93 of the second or three-crown region92 ofproximal stent70 is shown. Anouter surface170 ofapex93 takes on a circular radius of curvature as defined bycircle172 having a radius r₁. Aninner surface174 of thestent strut apex93 takes on an elliptical shape as shown byellipse176. In the configuration of FIG. 10,circle172 andellipse176 offset as shown byreference numeral177; however, they may share a common center. Radius r₄shown at one of the foci ofellipse176; the foci are shown as separated by a distance171 in FIG. 10.
• We have found that for the NiTi stents used in the present invention, such a configuration provides for a more diffuse strain distribution in the stent and reduces the peak strains experienced during assembly and in vivo, while also allowing for a smaller delivery profile as compared to other configurations, particularly in the[0123]proximal apex93 of the second or three-crown region92 ofproximal stent70. However, the stent apex configuration of FIG. 10 may be used in any other stent or connector member apex described herein, and may be used for components comprising material other than NiTi.
• In the example of FIG. 10 wherein[0124]proximal apex93 of the second or three-crown region92, we have found that for NiTi components radius r₁of between about 0.030 and about 0.070 inch; specifically about 0.050 inch is useful, while an offset171 of between about zero and about 0.050 inch; specifically about 0.0025 inch, is effective. A radius r₄of between about 0.010 and about 0.030 inch; specifically about 0.020 inch, is useful as well.
• FIG. 11 details an alternative offset circular apex configuration. Here, a simplified detail of proximal apex[0125]94 in the first or six-crown region90 ofproximal stent70 is shown (without a transition region to the second or three-crown stent region as seen in, e.g., FIG. 4 for clarity of illustration). An outer surface180 ofapex94 takes on a circular radius of curvature as defined bycircle182 having a radius r₂. Aninner surface184 ofapex94 takes on a circular radius of curvature defined bycircle186 having a radius r₃Radius r₂may be equal to or greater than radius r₃and be within the scope of the present invention. The centers ofcircles182 and186 are offset from each other as indicated byreference numeral188 in FIG. 11. This offset188 may be equal to, greater than, or less than the width of thestrut71 in the region ofapex94.
• We have found that when NiTi is used for the stents and connector members of the present invention, such a configuration is effective in distributing the peak strains experienced in the stent from the apex[0126]94 tostent strut71 as compared to other configurations, particularly in theproximal apex94 of the first or six-crown region90 ofproximal stent70. However, the offset circular apex configuration of FIG. 11 may be used in any other stent or connector member apex described herein, and may be used for components comprising material other than NiTi.
• When used in the[0127]proximal apex94 of the proximal stent first or six-crown region90, we have found offset values ranging from about zero to about 0.030 inch; particular about 0.020 inch, to be effective in NiTi stents having expanded, or deployed diameters ranging from about 16 to about 26 mm. We have also found effective a configuration in which radius r₂ranges from about 0.020 to about 0.040 inch; more particularly about 0.035 inch, and in which radius r₃ranges from about 0.005 to about 0.020 inch; in particular about 0.010 inch.
• Optional taper or tapers may be incorporated into the[0128]struts41 and71 of the various stent embodiments of the present invention as well as the various proximal and distal connector members. In general, incorporating one or more tapers into the struts on both proximal and distal stents provide greater space in the tapered region to accommodate alternative features such as barbs and tuck pads. It allows for a smaller deployment profile when the component is in a radially collapsed delivery configuration. We have found that when configuring the various stents and connector elements of the present invention into this reduced diameter delivery profile, the stents experience a large degree of bending strain that is often poorly or locally distributed. Tapering certain stent struts in particular locations helps to distribute this strain more evenly throughout the stent or connector member and to manage the peak strains. The examples of FIGS. 12 and 13 are now introduced and discussed below.
• In FIG. 12, a simplified section of the second or three-[0129]crown region92 ofproximal stent70 is depicted in which the stent struts71 taper from a maximum width190 (which may or may not equal a width ofstrut71 in region of apex93) to aminimum width192. The optional taper, expressed as the ratio of themaximum width190 to theminimum width192, may vary widely depending on the particular region of the stent or connector member, the material used, and other factors. Taper ratios ranging from 1 to about 10 or greater are within the scope of the present invention. It is also within the scope of the present invention for the stent struts71 to exhibit no taper.
• For example, in a[0130]proximal stent70 three-crown region92 made from NiTi, we have found effective amaximum strut width190 ranging from about 0.016 to about 0.032 inch; particularly from about 0.022 and about 0.028 inch, and aminimum strut width192 of between about 0.010 and about 0.026 inch; particularly from about 0.012 and about 0.022 inch. The optional tapered strut feature described herein and shown in FIG. 12 may be used in any other stent or connector member described herein, and may be used for components comprising material other than NiTi.
• Turning now to FIG. 13, a simplified section of[0131]distal stent128 is shown as an example of optional tapering that results in asymmetric crowns. In this example,distal stent128 comprises a distal apex orcrown196 exhibiting awidth198 and a proximal apex or crown (withconnector element134 removed for clarity of illustration)200 exhibiting asmaller width202. It is within the scope of the present invention forwidth198 andwidth202 to be equal.
• We have found that, especially for the distal stents of the present invention, an asymmetric crown in which the[0132]distal apex200 has a smaller strut width than that of theproximal apex196 results in a difference in the expansion force exerted between each of the proximal and distal apices. When deployed in a diseased lumen or vessel, the proximal apices of such a stent having this configuration will tend to exert a smaller expansion force near the graft seal zone, reducing the potential for such a stent to cause trauma to tissue in the seal zone near the cuffs (where weaker, more diseased tissue tends to reside). Such a configuration also facilitates a consistent, safe and predictable deployment when the component moves from a reduced diameter delivery profile to an expanded treatment profile. Finally, such a taper reduces the flare exhibited by thedistal apex200; this in turn provides for a smaller distal stent delivery profile when the distal stent is in a reduced-diameter configuration. Taper ratios (defined in the same manner above as the ratio betweenwidth198 and width202) ranging from 1 to about 10 or higher are within the scope of the present invention.
• For[0133]distal stent128 comprising NiTi, we have found that awidth202 ranging from about 0.010 to about 0.026 inch; specifically from about 0.012 and about 0.024 inch to be useful, and we have found awidth198 ranging from about 0.016 to about 0.032 inch; specifically from about 0.017 to about 0.028 inch to be useful.
• Of course, the various types of offset radii and combinations of elliptical and circular apex radii may be used to effect these tapers and ratios so to further cause the desired behavior during assembly into a reduced-diameter delivery configuration, effective delivery and performance in vivo.[0134]
• Useful inflation media generally include those formed by the mixing of multiple components and that have a cure time ranging from a few minutes to tens of minutes, preferably from about three and about twenty minutes. Such a material should be biocompatible, exhibit long-term stability (preferably on the order of at least ten years in vivo), pose as little an embolic risk as possible, and exhibit adequate mechanical properties, both pre- and post-cure, suitable for service in the graft of the present invention in vivo. For instance, such a material should have a relatively low viscosity before solidification or curing to facilitate the graft cuff and channel fill process. A desirable post-cure elastic modulus of such an inflation medium is from about 50 to about 400 psi—balancing the need for the filled graft to form an adequate seal in vivo while maintaining clinically relevant kink resistance of the graft. The inflation media ideally should be radiopaque, both acute and chronic, although this is not absolutely necessary.[0135]
• Details of compositions suitable for use as an inflation medium in the present invention are described in greater detail in U.S. patent application Ser. No. 09/496,231 to Hubbell et al., filed Feb. 1, 2000 and entitled “Biomaterials Formed by Nucleophilic Addition Reaction to Conjugated Unsaturated Groups” and U.S. patent application Ser. No. 09/586,937 to Hubbell et al., filed Jun. 2, 2000 and entitled “Conjugate Addition Reactions for the Controlled Delivery of Pharmaceutically Active Compounds”. The entirety of each of these patent applications is hereby incorporated herein by reference.[0136]
• We have found one particular three-component medium formed by the Michael addition process to be particularly useful in serving as an inflation medium for the present invention. This medium comprises:[0137]
• (1) polyethylene glycol diacrylate (PEGDA), present in a proportion ranging from about 50 to about 55 weight percent; specifically in a proportion of about 52 weight percent,[0138]
• (2) pentaerthyritol tetra 3(mercaptopropionate) (QT) present in a proportion ranging from about 22 to about 27 weight percent; specifically in a proportion of about 24 weight percent, and[0139]
• (3) glycylglycine buffer present in a proportion ranging from about 22 to about 27 weight percent; specifically in a proportion of about 24 weight percent.[0140]
• Variations of these components and other formulations as described in copending U.S. patent application Ser. Nos. 09/496,231 and 09/586,937, both to Hubbell et al., may be used as appropriate. In addition, we have found PEGDA having a molecular weight ranging from about 350 to about 850 to be useful; PEGDA having a molecular weight ranging from about 440 to about 560 are particularly useful.[0141]
• Radiopaque materials as previously discussed may be added to this 3-component system. We have found that adding radiopacifiers such as barium sulfate, tantalum powder, and soluble materials such as iodine compounds to the glycylglycine buffer is useful.[0142]
• We have found that triethanolamine in phosphate-buffered saline may be used as an alternative to glycylglycine buffer as the third component described above to form an alternative curable gel suitable for use in embodiments of the present invention.[0143]
• An alternative to these three-component systems is a gel made via polymer precipitation from biocompatible solvents. Examples of such suitable polymers include ethylene vinyl alcohol and cellulose acetate. Examples of such suitable biocompatible solvents include dimethylsulfoxide (DMSO), n-methyl pyrrolidone (NMP) and others. Such polymers and solvents may be used in various combinations as appropriate.[0144]
• Alternatively, various siloxanes may be used as inflation gels. Examples include hydrophilic siloxanes and polyvinyl siloxanes (such as STAR-VPS from Danville Materials of San Ramon, Calif. and various silicone products such as those manufactured by NuSil, Inc. of Santa Barbara, Calif.).[0145]
• Other gel systems useful as an inflation medium or material for the present invention include phase change systems that gel upon heating or cooling from their initial liquid or thixotropic state. For example, materials such as n-isopropyl-polyacrylimide (NIPAM), BASF F-127 pluronic polyoxyamer, and polyethylene glycol (PEG) chemistries having molecular weights ranging between about 500 and about 1,200 are suitable.[0146]
• Effective gels may also comprise thixotropic materials that undergo sufficient shear-thinning so that they may be readily injected through a conduit such as a delivery catheter but yet still are able to become substantially gel-like at zero or low shear rates when present in the various channels and cuffs of the present invention.[0147]
• In the case of the three-component PEDGA-QT-glycylglycine formulation described above, a careful preparation and delivery protocol should be followed to ensure proper mixing, delivery, and ultimately clinical efficacy. Each of the three components is typically packaged separately in sterile containers such as syringes until the appropriate time for deploying the endovascular graft. The QT and buffer (typically glycylglycine) are first continuously and thoroughly mixed, typically between their respective syringes for approximately two minutes. PEGDA is then mixed thoroughly with the resulting two-component mixture for approximately three minutes. This resulting three-component mixture is then ready for introduction into the graft body section as it will cure into a gel having the desired properties within the next several minutes. Cure times may be tailored by adjusting the formulations, mixing protocol, and other variables according to the requirements of the clinical setting. Details of suitable delivery protocols for these materials are discussed in copending U.S. patent application Ser. No. 09/917,371 to Chobotov et al.[0148]
• We have found the post-cure mechanical properties of these gels to be highly tailorable without significant changes to the formulation. For instance, these gels may exhibit moduli of elasticity ranging from tens of psi to several hundred psi; the formulation described above exhibits moduli ranging from about 175 to about 250 psi with an elongation to failure ranging from about 30 to about 50 percent.[0149]
• Notably, we have found it helpful to add an inert biocompatible material to the inflation material. In particular, we have found that adding a fluid such as saline to the PEGDA-QT-glycylglycine formulation (typically after it has been mixed but before significant curing takes place) lowers the viscosity of the formulation and results in greater ease when injecting the formulation into the graft body section network of inflatable cuffs and channels without sacrificing the desired physical, chemical, and mechanical properties of the formulation or its clinical efficacy. In the appropriate volume percentages, adding materials such as saline may also reduce the potential for the inflation material such as PEGDA-QT-glycylglycine to pose an embolic risk in case of spillage or leakage. Saline concentrations as a volume percentage of the final saline/three-component formulation combination may range from zero to as high as sixty percent or more; particularly suitable are saline concentrations ranging from about twenty to about forty percent. We have found a saline volume concentration of about thirty percent to be most suitable. Alternatives to saline may include biocompatible liquids, including buffers such as glycylglycine.[0150]
• In more general terms, it is desirable to use an inflation medium in which each of its components is biocompatible and soluble in blood. A biocompatible inflation medium is desirable so to manage any toxicity risk in the case the inflation medium were inadvertently released into the patient's vasculature. A soluble inflation medium is desirable so to manage any embolism risk if released into the vasculature. Such an inflation medium should not disperse nor gel or solidify if spilled into flowing blood before curing. In the event of a spill, the normal blood flow would then rapidly disperse the components and their concentration would fall below the level required for crosslinking and formation of a solid. These components would then be eliminated by the body through standard pathways without posing an embolic risk to the patient. Among the many possibilities of an inflation medium example in which all of the components are soluble in blood is the combination polyethylene glycol diacrylate, a thiolated polyethyleneamine, and a buffer.[0151]
• As previously discussed, more than one type of inflation medium, or more than one variant of a single type of inflation medium may be used in a single graft to optimize the graft properties in the region in which it is disposed.[0152]
• For example, in the proximal and distal cuffs of the various embodiments of the present invention, the inflation material serves as a conformable sealing medium to provide a seal against the lumen wall. Desirable mechanical characteristics for the inflation medium in the proximal and distal cuffs would therefore include a low shear strength so to enable the cuff to deform around any luminal irregularities (such as calcified plaque asperities) and to conform to the luminal profile, as well as a high volumetric compressibility to allow the fill material to expand the cuffs as needed to accommodate any late lumen dilatation and maintain a seal.[0153]
• In the channel or channels, by contrast, the inflation medium serves primarily to provide structural support to the lumen within which the graft is placed and kink resistance to the graft. Desirable mechanical characteristics for the inflation medium in the channel or channels therefore includes a high shear strength, to prevent inelastic deformation of a channel or channel segment due to external compression forces from the vessel or lumen (due, for example, to neointimal hyperproliferation) and low volumetric compressibility to provide stable support for adjacent channels or channel segments that may be in compressive contact with each other, thereby providing kink resistance to the graft.[0154]
• Given these contrasting requirements, it may be useful to have different inflation materials fill different portions of the graft, such as one inflation medium for the proximal and distal cuffs and a second in the channel or channels.[0155]
• In the various embodiments of the present invention, it is desirable that the inflation medium be visible through the use of techniques such as fluoroscopy during the time of deployment in which the graft cuffs and channels are being filled with the inflation medium. Such visibility allows the clinician to verify that the cuffs and channels are filling correctly and to adjust the filling procedure if they are not. It also provides an opportunity to detect any leakage or otherwise undesirable flow of inflation material out of the graft so that injection may be stopped, thereby minimizing the amount of leaked inflation material.[0156]
• After the graft has been deployed into a patient, it is desirable that the graft be visible through the use of follow-up imaging techniques such as computed tomography (CT) and the like. However, the inflation material at this point in time is ideally not so radiopaque that it produces a dense CT image as such an image could potentially mask clinically significant endoleaks that would be visualized by opacifying the blood with a contrast agent.[0157]
• Balancing these two objectives is difficult, however, since CT techniques are much more sensitive in detecting small amounts of radiopaque matter than are fluoroscopy techniques. One solution is to use an inflation medium that becomes less radiopaque over time, such as for example by using a blend of radiopaque materials in which one or more will diffuse out of the inflation medium over time, thereby reducing the inflation medium's radiopacity. For instance, a blend of a soluble contrast agent such as an iodinated aqueous solution and an insoluble contrast agent such as barium sulfate may serve this purpose. The soluble contrast agent will diffuse through the graft body section pores some time after the graft has been implanted, resulting in a progressive decrease in radiopacity of the inflation material over time. A fill material radiopacifier prepared from a combination of about two percent barium sulfate (by weight) and about 20 percent iodinated contrast solution (by weight) is useful in this capacity.[0158]
• While particular forms of the invention have been illustrated and described, it will be apparent that various modifications can be made without departing from the spirit and scope of the invention.[0159]

Claims (33)

What is claimed is:

1. An endovascular graft comprising:

a graft body section having an inflatable cuff and wherein the inflatable cuff contains a three-component inflation medium.

2. The endovascular graft ofclaim 1 wherein the inflation medium comprises the combination polyethylene glycol diacrylate, pentaerthyritol tetra 3(mercaptopropionate), and a buffer.

3. The endovascular graft ofclaim 2 wherein the buffer comprises glycylglycine.

4. The endovascular graft ofclaim 2 wherein the buffer comprises triethanolamine in phosphate-buffered saline.

5. The endovascular graft ofclaim 2 wherein the polyethylene glycol diacrylate is present in a proportion ranging from about 50 to about 55 weight percent.

6. The endovascular graft ofclaim 2 wherein the polyethylene glycol diacrylate has a molecular weight ranging from about 350 to about 850.

7. The endovascular graft ofclaim 2 wherein the pentaerthyritol tetra 3(mercaptopropionate) is present in a proportion ranging from about 22 to about 27 weight percent.

8. The endovascular graft ofclaim 2 wherein the glycylglycine is present in a proportion ranging from about 22 to about 27 weight percent.

9. The endovascular graft ofclaim 1 wherein the inflation material is radiopaque.

10. The endovascular graft ofclaim 9 wherein the inflation material comprises a radiopaque material that is soluble in glycylglycine.

11. The endovascular graft ofclaim 9 wherein the inflation material becomes less radiopaque over time.

12. The endovascular graft ofclaim 11 wherein the inflation material comprises a radiopaque material comprising a blend of a soluble contrast agent and an insoluble contrast agent.

13. The endovascular graft ofclaim 1 wherein the soluble contrast agent comprises an iodinated aqueous solution and the insoluble contrast agent comprises barium sulfate.

14. The endovascular graft ofclaim 1 wherein a post-cure elastic modulus of the inflation medium is between about 175 and about 250 pounds per square inch.

15. The endovascular graft ofclaim 14 wherein the inflation medium exhibits a cure time between about two minutes and about ten minutes.

16. The endovascular graft ofclaim 1 wherein the inflation medium additionally comprises saline or other inert biocompatible material.

17. The endovascular graft ofclaim 16 wherein the inflation medium comprises between about 20 and about 50 percent by volume saline.

18. The endovascular graft ofclaim 1 wherein the inflation medium comprises polyethylene glycol diacrylate, a thiolated polyethyleneamine, and a buffer.

19. The endovascular graft ofclaim 1 wherein the inflation medium comprises polyethylene glycol diacrylate, a thiolated tetronic, and a buffer.

20. The endovascular graft ofclaim 1 wherein the graft body section comprises an inflatable channel in fluid communication with the inflatable cuff.

21. The endovascular graft ofclaim 20 wherein the inflatable cuff is disposed at a proximal portion of the graft body section and further comprising a second inflatable cuff disposed at a distal portion of the graft body section and wherein the second inflatable cuff is in fluid communication with the inflatable channel and inflatable cuff.

22. An endovascular graft comprising:

a main body portion having at least one inflatable cuff,

a first bifurcated portion forming a continuous lumen with the main body portion, said lumen configured to confine a flow of fluid therethrough,

at least one inflatable channel extending from the first bifurcated portion to the main body portion,

wherein the inflatable cuff is in fluid communication with the inflatable channel, and

wherein the inflatable channel and inflatable cuff contain a three-component inflation medium.

23. The endovascular graft ofclaim 22 wherein the inflation medium comprises the combination polyethylene glycol diacrylate, pentaerthyritol tetra 3(mercaptopropionate), and a buffer.

24. The endovascular graft ofclaim 22 wherein the inflation material is radiopaque.

25. The endovascular graft ofclaim 22 further comprising a second bifurcated portion and wherein the inflatable channel extends to the second bifurcated portion.

26. The endovascular graft ofclaim 25 wherein the inflatable channel extends to a distal inflatable cuff disposed at a distal portion of one or both of the first and second bifurcated portions, and wherein each of the inflatable channel, at least one inflatable cuff, and distal inflatable cuffs are in fluid communication with each other.

27. A kit for the endovascular delivery of a graft, comprising:

a graft body section having an inflatable cuff,

a three-component inflation medium, and

instructions for use.

28. The kit ofclaim 27 wherein the graft body section further comprises an expandable member disposed on the graft body section and extending away from a proximal portion thereof.

29. The kit ofclaim 27 wherein each of the three components of the inflation medium is packaged separately.

30. The kit ofclaim 27 wherein the graft body section further comprises an inflatable channel in fluid communication with the inflatable cuff.

31. The kit ofclaim 28 further comprising a second inflatable cuff disposed at a distal portion of the graft body section in fluid communication with the inflatable channel and inflatable cuff.

32. The kit ofclaim 27 wherein the graft body section comprises a main body portion and at least one bifurcated portion forming a continuous lumen with the main body portion, said lumen configured to confine a flow of fluid therethrough.

33. The kit ofclaim 27 wherein the instructions for use comprise directions for mixing each of the three components with each other in a particular sequence and for a particular amount of time prior to introducing the three-component mixture into the graft body section inflatable cuff.

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