US20030070683A1 - Methods and devices for use in performing pulmonary procedures - Google Patents

Abstract

An implantable flow control element is provided which prevents air from entering an isolated portion of a patient's lung. The element may permit air to escape from the isolated portion so that the element acts like a valve. Systems for implanting pulmonary devices are also provided.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS
• This application is a continuation of U.S. patent application Ser. No. 09/797,910, filed Mar. 2, 2001 entitled “Methods and Devices for use in Performing Pulmonary Procedures” by Deem et al., which is a continuation-in-part of U.S. patent application Ser. No. 09/519,735 filed Mar. 4, 2000 entitled “Methods and Devices for use in Performing Pulmonary Procedures” by Deem et al., the full disclosures of which are incorporated herein by reference.[0001]
BACKGROUND
• 1. Field of the Invention[0002]
• The present invention relates generally to methods and devices for use in performing pulmonary procedures, and more particularly, procedures for treating various diseases of the lungs.[0003]
• 2. Description of the Related Art[0004]
• Pulmonary diseases such as emphysema and chronic obstructive pulmonary disease (COPD) reduce the ability of one or both lungs to fully expel air during the exhalation phase of the breathing cycle. The diseased lung tissue is less elastic than healthy lung tissue, which is one factor that prevents full exhalation of air. During breathing, the diseased portion of the lung does not fully recoil due to the tissue being less elastic. Consequently, the diseased (e.g., emphysematic) lung tissue exerts a relatively low driving force, which results in the diseased lung expelling less air volume than a healthy lung. The reduced air volume exerts less force on the airway which allows the airway to close before all air has been expelled, another factor that prevents full exhalation.[0005]
• The problem is further compounded by the diseased, less elastic tissue that surrounds the very narrow airways that lead to the alveoli (the air sacs where oxygen-carbon dioxide exchange occurs). This tissue has les tone than healthy tissue and is typically unable to maintain the narrow airways open until the end of the exhalation cycle. This traps air in the lungs and exacerbates the already-inefficient breathing cycle. The trapped air causes the tissue to become hyper-expanded and no longer able to effect efficient oxygen-carbon dioxide exchange. Applying suction to these narrow airways (a procedure proposed in the literature for deflating the diseased portion of the lung) may collapse the airways due to the surrounding diseased tissue, thereby preventing successful fluid removal.[0006]
• In addition, hyper-expanded lung tissue occupies more of the pleural space than healthy lung tissue. In most cases, a portion of the lung is diseased while the remaining part is healthy and therefore still able to efficiently carry out oxygen exchange. By taking up more of the pleural space, the hyper-expanded lung tissue reduces the amount of space available to accommodate the healthy, functioning lung tissue. As a result, the hyper-expanded lung tissue causes inefficient breathing due to its own reduced functionality and because it adversely affects the functionality of adjacent healthy tissue.[0007]
• Lung reduction surgery is a conventional method of treating lung diseases such as emphysema. A diseased portion of the lung is surgically removed which makes more of the pleural space available to accommodate the functioning, healthy portion of the lung. The lung is typically accessed through a median sternotomy or small lateral thoracotomy. A portion of the lung, typically the upper lobe of each lung, is freed from the chest wall and then resected, e.g., by a stapler lined with bovine pericardium to reinforce the lung tissue adjacent the cut line and also to prevent air or blood leakage. The chest is then closed and tubes are inserted to remove air and fluid from the pleural cavity. The conventional surgical approach is relatively traumatic and invasive, and, like most surgical procedures, is not a viable option for all patients.[0008]
• More recently proposed treatments include the use of devices that employ RF or laser energy to cut, shrink or fuse diseased lung tissue. Another lung volume reduction device utilizes a mechanical structure that is used to roll the lung tissue into a deflated, lower profile mass that is permanently maintained in a compressed condition. As for the type of procedure used, open surgical, minimally invasive and endobronchial approaches have all been proposed. Another proposed device (disclosed in publication no.[0009]WO 98/48706) is positioned at a location in the lung to block airflow and isolate a part of the lung. The publication states that the occlusion device is introduced through an endobronchial delivery device, and is resiliently deformable in order to provide a complete seal against airflow.
• The search for new and better treatments underscores the drawbacks associated with existing pulmonary procedures. Accordingly, there is a need in the art for improved methods and devices for performing pulmonary procedures, and in particular, treating lung diseases such as emphysema.[0010]
SUMMARY
• In one embodiment, there is disclosed a method for treating a patient's lung. The method includes steps of selecting a hollow structure in a patient's lung, the hollow structure defining a pathway for conducting fluid flow in at least first and second directions, and allowing fluid flow within the pathway in the first direction while controlling fluid flow in the second direction.[0011]
• In another embodiment, there is disclosed a method for treating a patient's lung. This method includes steps of providing a valve which allows fluid flow in a first direction and limits fluid flow in a second direction, and positioning the valve at a desired location in a lung of a patient with the first direction corresponding to an exhalation direction and the second direction corresponding to an inhalation direction.[0012]
• In another embodiment, there is disclosed a method for treating a patient's lung that includes steps of providing a flow control element that limits fluid flow in at least one direction, positioning the flow control element at a location in a lung of a patient with the one direction substantially corresponding to an inhalation direction, and removing the flow control element after a period of time.[0013]
• In another embodiment, there is disclosed a method for treating a patient's lung, the method comprising steps of selecting a hollow structure in a patient's lung, the hollow structure defining a pathway for conducting fluid flow in at least first and second directions, applying suction to draw fluid through the pathway in the first direction, and substantially preventing fluid flow through the pathway in the second direction.[0014]
• In another embodiment, there is disclosed a system for treating a patient's lung. The system includes a flow control element sized and configured to be positioned in a hollow structure located in a patient's lung, the flow control element including a valve member that permits fluid flow in a first direction while substantially preventing fluid flow in a second direction. A delivery device is sized and configured to be guided to and positioned in or adjacent the hollow structure, and the flow control element is removably mounted on the delivery device. This valve may be a poppet, ball, duckbill, heimlick, flat or leaflet valve.[0015]
• In another embodiment, there is disclosed a system for treating a patient's lung. The system includes a measuring device for determining the approximate size of a hollow structure in a patient's lung, and a flow control element sized and configured to be positioned in a hollow structure located in a patient's lung, wherein the flow control element allows fluid flow in a first direction but substantially prevents fluid flow in a second direction.[0016]
• In another embodiment, there is disclosed a system for treating a patient's lung. This system includes a flow control element sized and configured to be positioned in a hollow structure located in a patient's lung, wherein the flow control element allows fluid flow in a first direction but substantially prevents fluid flow in a second direction, and a removal device for removing the flow control element from the hollow structure subsequent to positioning the flow control element in the hollow structure.[0017]
• In another embodiment, a blocking element is coupled to a delivery element. The blocking element is advanced to a location in a patient's lung. An expandable member is expanded to occlude a pulmonary passageway and air is then withdrawn from the lung. The blocking element is released to block air flow into the isolated portion of the lung. The blocking element may also be a valve. The expandable member may be carried by the delivery element or by a separate element.[0018]
• In still another embodiment, a device is advanced through the blocking element after implantation of the blocking element. A procedure, such as delivery or evacuation of fluids or liquids, may then be performed with the device. The device is then removed with the blocking element again preventing air from passing in the inhalation direction. The blocking element may also be a valve which permits air flow in an expiratory direction.[0019]
BRIEF DESCRIPTION OF THE DRAWINGS
• FIG. 1 is an elevation view schematically showing a system constructed according to one embodiment of the invention, the system being used to perform a pulmonary procedure on a patient;[0020]
• FIG. 2 is an enlarged elevation view of the lungs of the patient shown in FIG. 1 along with the system of the invention;[0021]
• FIG. 3 is an enlarged elevation view, in section, of a flow control element forming part of the system shown in FIG. 2, wherein the flow control element allows fluid flow in a first direction but blocks fluid flow in a second direction;[0022]
• FIG. 4 is an enlarged elevation view, in section, of an alternative flow control element that allows fluid flow in a first direction but blocks fluid flow in a second direction;[0023]
• FIG. 5 is an enlarged elevation view, in section, of another alternative flow control element;[0024]
• FIG. 6 is an enlarged elevation view, in section, of still another alternative flow control element;[0025]
• FIG. 7 is a perspective view of an introducer constructed according to another embodiment of the invention;[0026]
• FIG. 8 is an enlarged perspective view of a portion of the introducer shown in FIG. 7;[0027]
• FIG. 9 is a perspective view of a delivery device constructed according to another embodiment of the invention for delivering a flow control element to a selected location in a patient's lung;[0028]
• FIG. 10 is a perspective view of a measuring device constructed according to another embodiment of the invention for determining the size of a hollow structure prior to disposing a flow control element in the structure; and[0029]
• FIG. 11 is a perspective view of a removal device constructed according to another embodiment of the invention for removing a flow control element that has already been positioned in a hollow structure.[0030]
• FIG. 12 is a side view of another flow control element.[0031]
• FIG. 13 is another side view of the flow control element of FIG. 12.[0032]
• FIG. 14 is a cross-sectional view of the flow control element of FIG. 12.[0033]
• FIG. 15 is an alternative cross-sectional view of the flow control element of FIG. 12.[0034]
• FIG. 16 is an isometric view of the flow control element of FIG. 12 altered to have a tapered shape.[0035]
• FIG. 17 shows another flow control element.[0036]
• FIG. 18 is an end view of the flow control element of FIG. 17.[0037]
• FIG. 19 shows another flow control element.[0038]
• FIG. 20 shows still another flow control element.[0039]
• FIG. 21 is a side view of another flow control element.[0040]
• FIG. 22 is a cross-section of FIG. 21 along line A-A.[0041]
• FIG. 23 is a longitudinal cross-section of FIG. 21.[0042]
• FIG. 24 is an alternative embodiment of the flow control device of FIG. 21.[0043]
• FIG. 25 is a cross-section of FIG. 24 along line B-B.[0044]
• FIG. 26 shows another flow control element with a flap valve in a closed position.[0045]
• FIG. 27 shows the flap valve of FIG. 26 in an open position.[0046]
• FIG. 28 shows a slit valve in a closed position.[0047]
• FIG. 29 shows the slit valve in an open position.[0048]
• FIG. 30 shows a flow control element with bristles.[0049]
• FIG. 31 is a cross-sectional view of a ball valve.[0050]
• FIG. 32 is a cross-sectional view of a poppet valve.[0051]
• FIG. 33 shows a leaftlet valve.[0052]
• FIG. 34 is a cross-section of the leaflet valve of FIG. 33.[0053]
• FIG. 35 shows another flap valve.[0054]
• FIG. 36 is a cross-sectional view of the flap valve of FIG. 35.[0055]
• FIG. 37 shows still another flap valve.[0056]
• FIG. 38 is a cross-sectional view of the flap valve of FIG. 36.[0057]
• FIG. 39 shows a system for performing pulmonary procedures.[0058]
• FIG. 40 is a cross-sectional view of the distal end of the system of FIG. 39.[0059]
• FIG. 41 illustrates access of the isolated portion of the lung through the flow control element of the present invention.[0060]
• FIG. 42 shows a device passing through the flow control element of FIGS.[0061]12-15 with the valve sealing around the device.
DETAILED DESCRIPTION
• The present invention provides methods and devices for performing pulmonary procedures, for example, treating various lung diseases such as emphysema and COPD. One preferred embodiment of the invention provides a flow control element that allows fluid flow in a first direction and controls fluid flow in a second direction. As used herein, fluid means gas, liquid, or a combination of a gas(es) and liquid(s). In addition, controlled fluid flow, as used herein, means that the flow is altered in some manner, i.e., the flow is not unimpeded in the second direction. The specific manner in which fluid flow is controlled in the second direction depends on the construction of the flow control element. The flow control element may, for example, completely block, substantially block, limit, meter or regulate fluid flow in the second direction by a valve or other suitable structure.[0062]
• As an example, when positioned in a hollow structure in a patient's body, such as a bronchiole in one of the lungs, the flow control element is oriented to allow flow in the exhalation direction but prevent fluid flow in the inhalation direction. The flow control element has a valve member that opens during exhalation in order to deflate or decompress the isolated lung portion distal to the flow control element. This maintains the diseased tissue in a decompressed state which prevents further hyper-expansion of the tissue. The invention also permits slow decompression of the lung tissue over a short or extended period of time.[0063]
• The invention thus may be used to prevent fluid being drawn into one or more portion of a patient's lung. According to another aspect of the invention, a portion of the lung may be deflated by applying gentle suction (via the flow control element) to the hyper-expanded tissue without collapsing the walls of the narrow airways surrounded by diseased tissue. The suction draws air, liquid, mucous, etc., out of the lung portion to evacuate the diseased tissue. It will be recognized that these and other aspects of the invention may be practiced independently or in conjunction with each other.[0064]
• FIG. 1 is a schematic view showing a[0065]system10 constructed according to one embodiment of the invention for carrying out a pulmonary procedure on the lung L of a patient P. It should initially be noted that suitable systems, methods or devices outside of those specifically described herein may be used to practice the invention. As such, thesystem10 is exemplary only and includes abronchoscope12 having a steering mechanism schematically indicated at14, ashaft16, and aport18 which provides access to one or more working channels of the bronchoscope.
• FIG. 1 shows a[0066]delivery device20 constructed according to the invention. Thedelivery device20 is shown positioned in thebronchoscope12 in order to deliver aflow control element22. Thebronchoscope12 has been passed into the patient's trachea T and guided into theright bronchus24. Thedelivery device20 is then manipulated with respect to thebronchoscope12 viasteering mechanism14 to control placement of theflow control element22. With reference to FIGS. 1 and 7-9, thedelivery device20 is movable within a bronchoscope working channel26 (FIG. 8) and is guided into the desired location in the hollow structure, which in this case is abronchiole28. For purposes of explanation, thebronchiole28 feeds an upper lobe U of the lung L which represents a diseased lung portion. Thedelivery device20 is placed through theside port18 and into the workingchannel26, thedistal end30 of thedelivery device20 is moved out of the working channel, and theflow control element22 is secured in position in thebronchiole28.
• FIG. 2 is an enlarged view of the patient's lungs L shown in FIG. 1 after the[0067]introducer12 anddelivery device20 have been removed, theflow control element22 being left in thebronchiole28. Theflow control element22, shown in more detail in FIG. 3, is in the form of a valve with avalve member32 supported by aring34. It should be noted that FIG. 2 also illustrates a secondflow control element22A placed in abronchiole28A that feeds a lower lobe LL of the lung. Theflow control element22A includes avalve member32A anda-support ring34A and reduces or prevents fluid from being inhaled into the hyper-expanded tissue of the lower lobe LL. It will be understood that any number of flow control elements may be used in a given procedure.
• Referring to FIG. 3, which shows the[0068]flow control element22 in detail, thevalve member32 is a duckbill-type valve and has two flaps defining anopening36. Thevalve member32 is shown in a flow-preventing orientation in FIG. 3 with theopening36 closed. Thevalve member32 is configured to allow fluid flow in a first direction (along arrow A) while controlling fluid flow in a second direction (along arrow B). In this embodiment, fluid flow in the direction of arrow B is controlled by being completely blocked byvalve member32. The first and second directions in which fluid flow is allowed and controlled, respectively, are preferably opposite or substantially opposite each other, for example, as shown in the Figures. It will be appreciated, though, that the invention may be practiced with the first and second directions different but not opposite each other.
• As noted above, the[0069]valve member32 of theflow control element22 controls fluid flow by completely blocking such flow in the second direction. As such, thevalve member32 effectively functions as a one-way valve. Alternative embodiments of the invention utilize flow control elements that control fluid flow in the second direction without completely blocking such flow.
• FIG. 4 shows an exemplary[0070]flow control element38 constructed according to an alternative embodiment of the invention that limits, but does not block, fluid flow in at least one direction. Theflow control element38 comprises avalve member40 supported by aring42. Thevalve member40 is preferably a duckbill-type valve having a similar construction to that of thevalve member32, except that theflaps44 are formed, secured, oriented or otherwise configured to maintain a flow opening46 when in their flow-controlling (as opposed to flow-allowing) orientation. Theopening46 is sized and configured to achieve desired flow characteristics through theflow control element38.
• When the[0071]flow control element38 is in its flow-allowing orientation (not shown), theflaps44 spread apart and allow essentially unimpeded fluid flow out of the diseased lung portion. When theflow control element38 is in its flow-controlling orientation, as shown in FIG. 4, the flaps move together to defineopening46 which allows a predetermined amount of fluid to be inhaled into the lung portion. This is in contrast to flowcontrol element22 which blocks fluid flow into the lung when in a flow-controlling orientation. It will of course be recognized that FIG. 4 shows only one way to achieve limited fluid flow in a given direction. The specific manner in which flow control is obtained may vary according to the invention, e.g., by varying the number, size, shape or position of the flow openings on the flow control element.
• According to another aspect of the invention, the flow control element may be constructed to provide a pumping action that aids in moving gas or liquid within a hollow structure, such as a bronchiole. For instance, when the lung distorts during inhalation and/or exhalation, a mechanical pumping action is produced that may be used to move the gas or liquid to further deflate the isolated region of the lung. FIG. 5 shows an exemplary[0072]flow control element50 constructed according to this embodiment and including a pair ofvalve members52,54 supposed in series by aring56. Thevalve members52,54 each include a pair of flaps defining a valve opening (the valve members being shown in their closed, fluid flow blocking orientation in FIG. 5). Achamber58 is defined between thevalve members52,54 and produces a pumping effect on the fluid flowing through theflow control element50. The chamber would collapse and expand with movement of the bronchiole (or other hollow structure in which it is inserted) to pump fluid from the diseased lung tissue.
• The[0073]valve member54 is coupled to abellows60 to enhance the pumping action and/or to control the amount of force needed to open the valve member. Thewall62 defining thechamber58 is secured to thering56 so that thechamber58 occupies the entire interior of thering56. Theflow control element50 may have a different configuration wherein thechamber58 is defined by an air pocket located within thewall62. This may prevent fluid collecting in thechamber58. In addition, a power-driven pump may be used to draw fluid out of the lungs, e.g., a miniature batter-powered electric pump, or pumps that use physical or chemical characteristics, e.g., a change in air temperature, presence of an additional gas or liquid, change in pH, etc., to generate pumping force that evacuates air and mucous.
• FIG. 6 shows yet another alternative[0074]flow control element70 including avalve member72 comprising a pair of flaps defining an opening, andring74 supporting thevalve member72. Thevalve member72 is a duckbill-type valve that permits fluid flow in a first direction but prevents flow in a second direction. Thering74 in this embodiment comprises astent76 havingstruts78 to enhance fixation of theflow control element70 in the hollow body structure (not shown). Thevalve member72 may be attached to thestent76 by any suitable means, e.g., molded to the stent, suture, fasteners, adhesives, etc. Thestent76 is movable between collapsed and expanded (FIG. 6) orientations to enable easy delivery and deployment. That is, theflow control element70 includingstent76 may be collapsed and held in a sheath for delivery through a relatively small space, for example, the working channel of a bronchoscope. (A typical bronchoscope has a diameter of about 6 or 7 mm, while the working channel has a diameter of about 2 or 3 mm.) Utilizing a collapsible flow control element may also be useful in introducing the flow control element through an small opening formed in the patient's thorax.
• FIGS. 7 and 8 show in detail the[0075]bronchoscope12 and the flow controlelement delivery device20 described above in connection with FIG. 1. Thebronchoscope12 has aneyepiece80 which is used to visualize the trachea and the various pathways of the lung during deployment of theflow control element22. Thebronchoscope12 may be provided with a camera/recorder, an aspiration/irrigation system, or other auxiliary features. Thesteering mechanism14 may comprise cables that move the distal tip of thebronchoscope shaft16 over a desired angular range, for example, 0° through 180°. FIG. 8 shows thedistal portion30 of thebronchoscope12 including the working channel26 (which communicates with the side port18), one or more fiber optic light guides81, and alens82 for transmitting images to theeyepiece80.
• FIG. 9 shows the[0076]delivery device20 to include ahandle84, anactuator86, asupport shaft87 and asheath88. For purposes of illustration, thedelivery device20 will be described in connection with delivering theflow control element70 of FIG. 6, although it will be understood that it may be used to deliver alternative flow control elements. Theflow control element70, and in particular thestent76, is collapsed to a low profile orientation and then mounted on theshaft87. Thesheath88 is moved distally from the position shown in FIG. 9 until it covers the stent body76 (and thevalve member72, if desired) to maintain theflow control element70 collapsed. (This position of the sheath is omitted for clarity.) Theshaft87 andsheath88 are then passed into theside port18 and workingchannel26 of thebronchoscope12 and guided to a desired location in the lung. Theactuator86 is used to remove thesheath88 from theflow control element70 which allows thestent76 to expand.Stent76 is preferably formed of a self-expanding material, e.g., Nitinol. In this case theflow control element70 immediately expands and engages the tissue upon retraction ofsheath88. Alternatively, the stents could rely on a mechanism such as a balloon or heat activation to expand in use.
• The flow control element of the invention may be guided to and positioned at a desired location in the pulmonary system, such as the[0077]bronchiole28 shown in FIGS. 1 and 2, by various delivery devices or systems. For example, guidewire-based systems, introducer sheaths, cannulae or catheters, etc., may be used to deliver the treatment element in a minimally invasive manner. The above-described method for using a bronchoscope to introduce the flow control element may be modified by placing an introducer sheath over the bronchoscope. The sheath provides access should the bronchoscope need to be removed from patient's body, for example, in order to place a different size flow control element.
• The invention is preferably carried out by first determining the approximate size of the target lumen, i.e., the hollow structure in which the flow control element will be placed. FIG. 10 shows somewhat schematically an exemplary device for determining the size of a hollow structure in a patient's body, for example, a bronchiole in a lung. The[0078]device90 includes ahousing92,shaft94, positioning element,96 and measuringelements98. The measuringelements98 havetips100 that are moved into contact with the wall of the hollow structure, such as the inner surface of a bronchiole (not shown). Thedevice90 is calibrated so that whentips100 of measuringelements98 engage the wall of the bronchiole theindicator102 displays the approximate size of the bronchiole. Anelectrical coupling104 powers thedevice90.
• The[0079]positioning element96 is optional and may be used to fix the position of the measuringelements98 within the bronchiole so as to obtain more precise measurement. The illustratedelement96 is an inflatable balloon, although other elements could be used to center and hold theshaft96 within the bronchiole. Any suitable means may be used for ensuring that the measuringelements98 do in fact contact the bronchiole wall in order to provide a true reading. The measuringelements98 may be moved distally (to the right in FIG. 10) until a visual indicator indicates that thetips100 are in contact with tissue. Alternatively, a change in electrical resistance may be used to confirm contact between the measuringelements98 and tissue. It should be noted that thedevice90 is merely representative of the various means that may be used to determine the size of a hollow body structure.
• In use, the[0080]shaft94 of the measuringdevice90 is passed through thebronchoscope working channel26 and delivered to the site. Thedevice90 is then operated as described above to determine the approximate size of the bronchiole. The degree of precision with which the size of the hollow structure is measured will depend on the procedure being performed and user preference. After determining the size of the bronchiole thedevice90 is removed from workingchannel26, anddelivery device20 is inserted into the channel to deploy the flow control element in the bronchiole.
• It may in some instances be necessary or desirable to remove a flow control element from a hollow structure in which it has been deployed. As an example, it may be the case that placement of a flow control element for a given period of time effects beneficial results on the diseased lung tissue. The time during which the diseased tissue is deflated and decompressed may allow the tissue to regain some elasticity as a result of being temporarily inactive. After the tissue has regained some or all of its elasticity, it would be better to remove the flow control element and allow the tissue to function efficiently. The flow control element, however, is preferably not removed before the tissue has a sufficient chance to recover.[0081]
• Accordingly, the invention also provides methods and devices for removing a flow control element from a hollow structure such as a bronchiole in a patient's body. FIG. 11 shows a[0082]device110 comprising ahandle112, anactuator114, ashaft116 and one ormore removal components118. Thecomponents118 preferably havetips120 configured to grasp a flow control element in order to remove the element from surrounding tissue. Theshaft116 of thedevice110 is passed into a patient's trachea (not shown) and is guided to the previously-deployed flow control element; for example, theshaft116 may be introduced through the working channel of a bronchoscope in the same manner as thedelivery device20. Theremoval components118 are preferably collapsed withinshaft116 while the shaft is guided to the site. Thecomponents118 are then extended into contact with the wall of the bronchiole. Thetips120 are used to grasp and remove the flow control element from the bronchiole.
• The flow control element of the invention is secured in position in the hollow structure, such as[0083]bronchiole28, so as to remain in place during breathing. The exterior of the flow control element may be configured along all or part of its exterior to aid in fixing the element in place, for instance, as schematically indicated byreference numeral48 in FIGS. 3 and 4. Thefixation structure48 may comprise adhesives, tissue growth-inducing substances, fasteners, staples, clips, suture, stents, balloons, Dacron® sleeves, sintered, etched, roughened, barbed or alternatively treated surfaces, etc.
• Placement of a flow control element constructed according to the invention in a patient's pulmonary system achieves several benefits. With reference to the illustrated[0084]flow control element22, when deployed in thebronchiole28 as shown in FIGS. 1 and 2, the element shows exhalation but prevents inhalation. Theflow control element22 thus limits or prevents the inhalation of additional fluid into the diseased lung portion. This is beneficial because it prevents further enlargement of the hyper-expanded tissue, which in turn maintains more room in the pleural space for healthy lung tissue. Theflow control element22 also allows any air being naturally exhaled by the patient (as well as any liquid, if present) to exit the lung, thereby deflating or compressing the tissue. The fluid is preferably permitted to flow unimpeded from the lung, but it may instead be metered or regulated in order to control deflation.
• Referring to FIGS.[0085]12-16, anotherflow control element22 is shown. Theflow control element22 serves as a blocking element which blocks air in the inhalation direction. The blocking element may also have avalve124 which permits air flow in an exhalation direction but prevents air flow in the inhalation direction. Thevalve124 may be any suitable valve such as any of the valves described herein. For example, FIGS. 13 and 16 show thevalve124 having afirst lip126 and asecond lip128 which engage one another in the closed position. The term valve as used herein may also refer to a check valve which permits flow in one direction but prevents flow in the other direction. Although the valves described herein are used with various aspects of the invention, other aspects of the invention may be practiced by blocking flow in both directions. For example, the devices and methods for accessing the isolated part of the lung may be used with devices which block air flow in both directions. Finally, flow in the exhalation direction may be regulated in another manner as described herein rather than simply with the valve.
• The[0086]flow control element22 has anexpandable support structure130. Thesupport structure130 is metallic and preferably a superelastic material such as Nitinol. Thesupport structure130 is formed by cutting, etching or otherwise removing material from a tube to formopenings132 as is generally known in the art of forming small, metallic tubes such as stents. Of course, thesupport structure130 may be made in any other suitable manner and with other suitable materials. As an example, thesupport structure130 may be a Nitinol tube which is laser cut to have six diamond-shapedopenings132.
• The[0087]flow control element22 has abody134 coupled to thesupport structure130. The body is preferably molded silicone or urethane but may be any other suitable material. Thevalve124 is mounted to thebody134 and may be integrally formed with thebody134 as described below. Thebody134 may be attached to thesupport structure130 in any suitable manner. For example, thebody134 may be positioned in thesupport structure130 and anend136 averted over anend138 of thesupport structure130. Theend136 is attached to the rest of thebody134 through theopenings132 in thesupport structure130 atconnections140 with an adhesive, adhesive rivet, heat weld or any other suitable method. An advantage of coupling thebody134 to thesupport structure130 with theconnections140 is that thesupport structure130 andbody134 may collapse and expand somewhat independently since theconnections140 are free to move in theopenings132.
• The[0088]flow control element22 may also have a sealingportion142 which forms a seal with the wall of the pulmonary passage. The sealingportion142 may be attached to thebody134 separately (FIG. 14) or may be integrally formed with thebody134 and valve124 (FIG. 15). An advantage of theflow control element22 is that a substantial portion of theelement22, such as thebody134 andvalve124, are integrally formed. In the embodiment of FIG. 15, thevalve124,valve body134 and sealingportion142 are all integrally formed. The sealingportion142 extends around thevalve124 but is not coupled directly to thevalve124 so that thevalve124 is not subjected to forces exerted on or by the sealingportion142. The sealingportion142 extends from atube144 positioned around thevalve124.
• The sealing[0089]portion142 forms aring146 around thebody134. Thering146 is made of a resilient, elastomeric material which improves sealing with the wall of the pulmonary passage. Thering146 may have any suitable shape such as straight, tapered, angled or could havefrustoconical surface143 which angles thering146. The sealingportion142 preferably forms tworings146, and preferably three, which each have a different diameter to seal with different size passages. In this manner, the device may be used within a given size range. Thering146 also may be designed to deflect to permit exhalation air to pass. During coughing, for example, thevalve124 will, of course, open to permit air to escape, however, the pressure force on thevalve124 can be reduced if the sealingportion142 also opens to permit further venting of the isolated portion of the lung. As will be explained below, various other structures may also be used to provide valves which cooperate with the wall of the pulmonary passageway to permit venting of the isolated area.
• The[0090]body134 is coupled to thesupport structure130 to provide anexposed part135 of thesupport structure130 which helps to anchor the device. The term exposed part shall mean a part of thesupport structure130 not covered by thebody134. Of course, the exposedpart135 may be covered by another material so long as it is not covered by thebody134. The exposedpart135 of thesupport structure130 may form anchoringelements148 which anchor thesupport structure130. The anchoringelements148 are preferably v-shaped to improve anchoring. Of course, the anchoringelements148 may also be barbs or the like. Referring to FIG. 16, theflow control device22 may also be angled, tapered or flared so that oneend151 is larger than the other149. Of course, any other shape, such as a cylinder or tube flared at both ends, may be used without departing from many aspects of the invention.
• Referring to FIGS. 17 and 18, another[0091]flow control element22 is shown wherein the same or similar reference numbers refer to the same or similar structure. Theelement22 has avalve150 which has first andsecond lips152,154 which engage one another in a closed position. Thefirst lip152 is preferably stiffer than thesecond lip154 so that thefirst lip152 biases thesecond lip154 closed. Thefirst lip152 may be made stiffer than thesecond lip154 in any manner such as by using a thicker layer of the same material, a stiffer material for the first lip, or by simply adhering or attaching astiffener156 to thefirst lip152. The first andsecond lips152,154 are preferably formed by a tube of material with thestiffener156 attached to one side to form thefirst lip152. The first andsecond lips152,154 are also preferably curved as shown in FIG. 18. Theelement22 is preferably made of molded silicone or urethane although any other suitable material may be used. Thevalve150 also has reinforcingelements155 at the lateral edges to further support thelips152,154. Thevalve150 may, of course, have either theelements155 orstiffener156. Although the sealingportion142 is not shown for clarity, the sealingportion142 may also be provided.
• Referring to FIG. 19, another[0092]flow control element22 is shown wherein the same or similar reference number show the same or similar structure. Theflow control element22 has thevalve124 and a number of sealingportions142. Thevalve124, sealingportion142 andbody134 are integrally formed of a resilient material such as molded silicone or urethane. Of course, various other constructions may be used with theflow control element22 without departing from the scope of the invention. Theflow control element22 may also have reinforcing element158 such as ahelical coil160.
• Referring to FIG. 20, still another[0093]flow control element22 is shown wherein the same or similar reference numbers refer to the same or similar structure. Theflow control element22 has a sealingportion142 which has a helical shape. In one method of implanting the device, theelement22 is rotated so that the helical shape of the sealingportion142 engages the wall to anchor theelement22.
• Any of the flow control elements of the present invention may also be used with a[0094]sealant162, such as an adhesive, which seals and/or anchors the device. Referring to FIG. 20, thesealant162 is positioned on the exterior of the device between the sealingportions142. Thesealant162 is preferably a viscous substance which is applied to the exterior surface of the device before introduction. Thesealant162 may be an adhesive which also helps to anchor the device. The use of thesealant162 may be used with any of the devices described herein.
• Referring to FIGS.[0095]21-23, still anotherflow control element22 is shown wherein the same or similar reference numbers refer to the same or similar structure. Theflow control element22 has asupport structure164 which anchors avalve166. Thestructure164 has anchoringelements168, preferably two, on each side of thevalve166. The anchoringelements168 are formed by two wires attached together. Of course, any other suitable structure may be used for thestructure164 such as a stent-like structure or an expandable ring with barbs.
• The[0096]valve166 cooperates with the wall of the pulmonary passageway to vent the isolated area. Thevalve166 is generally conical, however, any other shape may be used. Thevalve166 may engage the pulmonary wall with a number of different configurations without departing from the scope of the invention, thus, the following preferred embodiments do not limit the scope of the invention. Thevalve166 is elastic and yields to permit expiratory air to pass between the valve and the wall of the passageway. Referring to FIG. 22, thevalve166 is thinner near an end engaging the wall W so that the end of thevalve166 is more flexible.
• Referring to FIGS. 24 and 25, still another device is shown wherein the same or similar reference numbers refer to the same or similar structure. The device has a[0097]valve170 with a number ofsections172 with eachsection172 forming a seal with the wall of the pulmonary passage. Thesections172 are separated bywires169 which provide a resilient structure. The device may be formed with any number of thesections172 forming avalve structure173 with the wall of the pulmonary passage.
• Referring to FIGS. 26 and 27, still another[0098]flow control element22 is shown wherein the same or similar reference numbers refer to the same or similar structure. Theelement22 has aflap valve174 which opens to permit expiratory air to pass. Thevalve174 is also generally conical. The term generally conical as used herein means that the cone may diverge from a cone in that the walls may be slightly curved, have a number of sections or a seam, flap or fold while still being generally cone-shaped.
• Referring to FIGS. 28 and 29, still another valve is shown having a slit or[0099]seam178 which opens to permit expiratory air to pass. The slit orseam178 may also be oriented and configured like a slit valve without departing from the scope of the invention.
• Referring to FIG. 30, still another[0100]flow control element22 is shown in which the same or similar reference numbers refer to the same or similar structure. The device has thevalve124 but may have any other suitable valve. The device hasflexible bristles180, preferably more than 10, 20 or even 30bristles180, which anchor the device in the pulmonary passageway. Thebristles180 are preferably angled to resist forces in the expiratory direction so that pressure forces, such as forces developed during coughing, cannot dislodge the device. Thebristles180 may be used with thesealant162 to provide an airtight seal.
• Referring to FIG. 31, still another[0101]flow control element22 is shown which includes a sealing element, such as aball valve184, biased toward the closed position to form aball valve183. Theball valve184 is biased with aspring186 although any other biasing element may be used. The device has abody188 with the sealingportion142. Thebody188 has anopening190 through which air may pass when theball valve184 opens. Referring to FIG. 32, still another device is shown which has a blockingelement185 rather than theball valve184 of FIG. 31 to form apoppet valve187.
• Referring to FIGS. 33 and 34, still another[0102]flow control element22 is shown. The device has avalve189 which has at least threeleaflets191 which engage one another in the closed position. Referring to FIGS. 35 and 36, still another device is shown having aflap valve193. Theflap valve193 deflects to permit expiratory air to pass. Theflap valve193 is preferably made of an elastomeric material. Theflap valve193 is attached to asupport strut192 extending across anopen end194 of thebody196. Thebody196 has the sealingportion142 which is preferably formed by ribs extending around the-body196. Referring to FIGS. 37 and 38, anotherflap valve198 is shown. Theflap valve198 is attached to the body athinge199.
• Referring to FIGS. 39 and 40, another[0103]system200 for deploying a device to a pulmonary location is shown. Thesystem200 is, of course, useful for delivering any of the devices described herein or any other suitable device. Thesystem200 includes adelivery element202 having afirst lumen204 and asecond lumen206. Thedelivery element202 also has anexpandable member208, such as aballoon210, which is in fluid communication with thesecond lumen206 for inflating theballoon210 with a source of inflation fluid orgas212. The device is loaded into the end of thedelivery element202 and apusher214 may be used to move the device, such as the device of FIGS.12-16, out of thedelivery element202. Thefirst lumen204 has an enlarged end which forms acapsule215 which contains the device. Theelement202 may also be advanced over aguidewire217 or the like in a conventional manner.
• The[0104]delivery element202 may also be used to remove air, and even fluid if necessary, from the isolated portion of the lung. Theexpandable member208 is expanded to isolate a portion of the lung and suction is applied to deflate the lung. The isolated portion of the lung may be deflated with the device contained within thedelivery element202 or may be deflated after delivery of the device. An advantage of using the valves of the present invention is that air can be drawn through the valve even after the valve has been deployed. Referring to FIG. 40, thevalve124 also may remain operational even when in the collapsed position. Thus, the isolated portion of the lung may also be suctioned when the device is contained in the first lumen. Thesecond lumen206 of thedelivery element202 may be substantially independent of the outer wall of thedelivery element202 so that the stiffness of the device is reduced as compared to an integrally formed multi-lumen device. Thesecond lumen206 is formed by a separate tube passing through thefirst lumen204. In another aspect of the invention, thedelivery element202 has an outer diameter which is 80-120%, more preferably 90-110%, of the minimum placement size of the device.
• Referring now to FIGS. 39, 41 and[0105]42, the isolated portion of the lung may be accessed after implantation of a device for subsequent medical treatments. For example, the valve may be penetrated with thedelivery device202, or similar device, to deliver and/or evacuate gas or liquid. The device is coupled to a source offluid211, such as an antibiotic or antisurfactant, which is delivered and, if necessary, evacuated from the lung. A gas, such as an antibiotic gas, may also be delivered from a source ofgas213 to the isolated area to reach distal portions of the isolated area. Finally, thedevice202 may be coupled to avacuum source215 for deflating the isolated portion or evacuating mucous or other fluids from the isolated portion of the lung. Avalve216 is provided for selectively coupling thefirst lumen204 to any of the source offluid211,gas213 orvacuum215.
• Referring to FIG. 42, the[0106]device202 may form a tight seal with thevalve124 so that the isolated portion remains deflated during the procedure. Alternatively, thedevice202 may have theexpandable element208, such as theballoon210, for occluding the pulmonary passageway on either side of thevalve124 to achieve isolation at any particular location in the pulmonary passageway distal or proximal to thevalve124.
• An advantage of the present invention is that the isolated portion may be deflated after implantation of the valve without penetrating the valve. The device may be positioned proximal to the valve and the expandable element expanded to occlude the pulmonary passageway. Suction is then applied through the device so that a low pressure area develops between the valve and occluding member. When the pressure differential is large enough, the valve will open to vent and deflate the isolated portion of the lung. This process can be continued in a controlled manner until the desired amount of deflations is achieved or when a target pressure has been reached. When suction is stopped, the valve will close to isolate part of the lung.[0107]
• After deployment of the valve, the delivery device, or other suitable device, may also be used as a diagnostic tool. For example, the balloon may be deflated momentarily so that the isolated area between the balloon and valve increases in pressure. If the pressure decreases after the balloon is inflated again it may indicate that the valve is not sealing properly since the air may be passing around or through the valve and into the isolated portion. An alternative diagnostic would be to pressurize the space between the valve and expandable member. The pressure response can then be monitored to determine if the valve provides an adequate seal.[0108]
• The devices and valves of the present invention provide the ability to prevent inflation of diseased areas of the lung while also permitting venting of these portions of the lung. The valves preferably open with a relatively small pressure differential across the valve. For example, the valves preferably open with a pressure differential of no more than 10 inches water more preferably no more than 5 inches water and most preferably no more than 1 inch water. Although the valves and valve elements of the present invention may open with relatively small pressure differentials, the valves and valve elements may also have higher opening pressures. For example, the valves may also be designed to open only for high pressure events such as coughing. For such valves, the opening pressure, or differential pressure, is at least 25 inches water but still no more than 120 inches water. In accordance with a method of the present invention, coughing may be induced to increase the driving force and respiratory pressure to vent the isolated portions of the lung.[0109]
• The flow control elements of the invention permit the diseased tissue to gradually deflate, either under the patient's own power or by applying relatively gentle suction for a given period of time. The suction may be applied intermittently or continuously by any suitable means. For example, a suction catheter could be passed through the flow control element in the bronchiole and into the distal tissue. The flow control element, for example, a valve member, would preferably seal around the catheter in order to prevent fluid moving distally past the valve.[0110]
• The invention thus provides significant benefits as it permits fluid to be evacuated from the alveoli without collapsing the floppy walls of the narrow airways leading to them, problem with common lung diseases such as emphysema and COPD, as discussed above. Accordingly, the invention facilitates removal of more fluid from the diseased lung tissue than prior art approaches, the effect of which is more pleural space available to the healthy lung tissue.[0111]
• In addition, as noted above, using the invention to deflate the diseased lung tissue for a selected period of time., e.g., one month, may have beneficial results on the tissue by temporarily removing it from the respiratory circuit. The flow control element is preferably removed before the tissue begins to necrose, but is left in place a sufficiently long enough time that the tissue will not revert to its floppy, toneless state when the element is removed. Stated otherwise, it may be possible to use the invention as a means for repairing (rather than removing or obliterating) diseased lung tissue, either by controlling the fluid flow in the lung tissue or by controlling the fluid flow in combination with delivering one or more substances.[0112]
• For example, some possible substances with which the invention may be used include gene therapy or angiogenesis factors for lung repair or reestablishment of tissue elasticity; growth factors; anti-growth or anti-angiogenesis factors (or substances to cause necrosis or apoptosis) to prevent re-establishment of air and blood flow; antibiotics to prevent infection; anti-inflammatory agents including steroids and cortisones; sclerosing drugs or materials to promote rapid healing, for example, to allow earlier removal of the flow control element; agents for absorbing remaining fluids; and sealing substances for enhancing isolation of the diseased tissue.[0113]
• The portion of the lung being treated may de deflated over time through repeated natural inhalation and exhalation with the flow control element in place. Alternatively or additionally, a vacuum source may be coupled to the flow control element to draw fluid out of the diseased tissue in the manner discussed above. This deflation of the diseased portion may be performed alone or in conjunction with delivering biological substances. The pressures used to suction the lung portion are preferably low to avoid collapsing the walls of the narrow airways.[0114]
• In the embodiments in which the flow control element comprises a valve, it may be formed of various materials and may be constructed in various manners. As an example, the valve may comprise an annulus or support ring formed of any suitable metal or synthetic material, with the valve member being formed of silicone, natural rubber, latex, polyurethane, polytetrafluoroethylene, a thermoplastic elastomer, tissue, etc. The valve member may be integral with the support ring or it may be a separate member attached thereto by suitable means, e.g., suture, adhesives, mechanical fasteners. If the flow control element comprises a stent with a valve prior art attachment methods may be used. For example, see U.S. Pat. No. 5,954,766, the content of which is incorporated herein in reference.[0115]
• The specific characteristics of the flow control element may be varied depending on the particular application. It may be desirable to provide multiple flow control elements with valve members that require different exhale pressures to open, for example, in order to allow treatment of patients who generate different exhalation pressures. The different flow control elements could be provided in a kit and be distinguished from each other based on required opening force, size, material, etc. The kit could include a color or other coding system to indicate these factors.[0116]
• The flow control elements of the invention are preferably constructed so as to require a relatively low opening force in order to allow fluid flow in the first direction. Emphysema patients typically exhale a small quantity of low-pressure fluid. The invention preferably allows any such fluid to escape via the flow control element in the hollow structure. As such, the flow control element is designed to open and allow flow in the first direction in response to any positive pressure generated by the patient. Put another way, as long as some pressure differential exists between the distal lung tissue and the proximal portion of the bronchiole, the flow control element will open to allow fluid to escape the tissue. It will nonetheless be recognized that the particular force required to open the flow control element may be varied depending on exhalation pressures associated with the intended patient population.[0117]
• It will be appreciated that features of the various preferred embodiments of the invention may be used independently or in conjunction with one another, while the illustrated methods and devices may be modified or combined in whole or in part. The inventive devices may include removable or detachable components, and may comprise disposable or reusable components, or a combination of disposable and reusable components. Likewise, it will be understood that the invention may be practiced with one or more of the steps specifically illustrated and described herein modified or omitted.[0118]
• It should also be recognized that the invention is not limited to treating lung diseases as is shown in the Figures, although that is a preferred application. The invention may be used in any pulmonary or non-pulmonary procedure in which it is desirable to allow fluid flow in a first direction and control fluid flow in a second, different direction within a hollow structure. Finally, it will be understood that although a minimally invasive, endobronchial approach is shown in the Figures, other approaches may used, for example, an open surgical procedure using a median sternotomy, a minimally invasive procedure using a mini thoracotomy, or a still less invasive procedure using one or more ports or openings in the thorax, etc.[0119]
• The preferred embodiments of the invention are described above in detail for the purpose of setting forth a complete disclosure and for sake of explanation and clarity. It will be readily understood that the scope of the invention defined by the appended claims will encompass numerous changes and modifications.[0120]

Claims (17)

What is claimed is:

1. A system for delivering an element into the pulmonary system, comprising:

a delivery element having a first lumen; and

a pulmonary element releasably coupled to the delivery element, the pulmonary element and delivery element being configured for intrapulmonary delivery, the pulmonary element at least blocking air flow into an isolated portion of a patient's lung.

2. The system ofclaim 1, further comprising:

a source of vacuum coupled to the first lumen.

3. The system ofclaim 1, wherein:

the delivery element has an expandable member mounted thereto for occluding a pulmonary passageway.

4. The system ofclaim 1, wherein:

the delivery element has a second lumen, the expandable member being a balloon which is coupled to the second lumen for inflating the balloon.

5. The system ofclaim 1, wherein:

the pulmonary element is a valve which permits air flow in one direction and blocks air in the other direction.

6. The system ofclaim 1, wherein:

the pulmonary element is mounted within the first lumen.

7. The system ofclaim 6, wherein:

the first lumen has an enlarged distal end, the pulmonary element being positioned in the enlarged portion of the first lumen.

8. The system ofclaim 1, further comprising:

a source of fluid coupled to the first lumen.

9. The system ofclaim 8, wherein:

the source of fluid contains a fluid selected from the group consisting of therapeutic agent, antibiotic, saline, sealant and adhesive.

10. A system for delivering an element into the pulmonary system, comprising:

a delivery element having a first lumen; and

means for controlling fluid flow into an isolated portion of a patient's lung, the means for controlling dimensioned for insertion in the first lumen and also dimensioned for insertion into a bronchial passageway.

11. The system ofclaim 10, wherein the delivery element is a bronchoscope and wherein the first lumen is a working channel of the bronchoscope.

12. The system ofclaim 10, wherein the means for controlling includes a one-way valve that permits fluid flow in a first direction and prevents fluid flow in a second direction.

13. The systemclaim 10, wherein the means for controlling is configured to block fluid flow.

14. The system ofclaim 10, wherein the means for controlling includes an expandable support structure.

15. The system ofclaim 14, wherein the expandable support structure comprises a frame.

16. The system ofclaim 14, wherein the expandable support structure comprises Nitinol.

17. The system ofclaim 10, wherein the means for controlling includes a sealing portion that can form a seal with a wall of the bronchial passageway.

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