US20020023893A1 - Closure for vial - Google Patents

Abstract

A closure for a vial includes a head portion, and a stem portion which projects from a lower surface of the head portion, the stem portion being inserted in an opening of a vial; wherein the stem portion is provided with a small diameter portion and a seal portion, in that order from the lower surface the head portion, the diameter of the small diameter portion being smaller than the diameter of the seal portion. The entirety of the small diameter portion and the seal portion are substantially uniformly fitted in the opening of the vial.

Description

BACKGROUND OF THE INVENTION
• 1. Field of the Invention[0001]
• The present invention relates to a closure to close an opening of a medical vial (container) which holds therein liquid medicament.[0002]
• 2. Description of the Related Art[0003]
• In general, a closure (rubber closure) for a vial is made of a rubber material such as butyl rubber and has a cylindrical stem portion which can be inserted in the opening of the vial and a head portion which has a diameter larger than that of the stem portion and which is located on the outside of the opening of the vial. The stem portion of a conventional closure is provided with a close contact portion (barrel portion) having a uniform diameter which is brought into close contact with the opening of the vial and which is located adjacent to the head portion, or is provided on its barrel portion with a sealing annular projection which is in close contact with the opening of the vial. A desired position of such a sealing annular projection is disclosed, for example, in Japanese Unexamined Utility Model No. Sho-61-2233.[0004]
• When the stem portion is fitted in the opening of the vial, the sealing annular projection is compressed more than the remaining portion of the barrel portion, and hence, it has been considered that the sealing annular projection contributes to preventing the stem portion from slipping off from the opening of the vial. In particular, for a specific type of vial, called a CS vial (Fuji Glass CO., Ltd.) which is provided, on the end of the opening thereof, with an inner small diameter portion (inner flange), the sealing annular projection engages with the small diameter portion, so that the slip-off prevention effect can be enhanced.[0005]
• However, if the closure is used with a vial other than a CS vial, the sealing annular projection which is compressed more than the remaining portion sometimes produces a force in a direction opposite to the direction of insertion to thereby disengage the closure from the vial. Because of this phenomenon, the sealing annular projection has also been regarded as having an opposite effect to that of slip-off prevention.[0006]
SUMMARY OF THE INVENTION
• It is an object of the present invention to eliminate the drawbacks and resolve the problems mentioned above, by providing a closure for a vial in which the slip-off prevention effect of the closure from the vial can be enhanced.[0007]
• It has been conceived by the inventors that by providing a small diameter portion on the end of the stem portion adjacent to the head portion, instead of a sealing annular projection, the material of the portion of the stem portion of the closure that is compressed when the stem portion is inserted in the opening of the vial is moved into the small diameter portion. Consequently, no force to disengage the closure from the vial opening occurs, unlike the conventional closure having the sealing annular projection.[0008]
• To achieve the object mentioned above, according to the present invention, a closure for a vial is provided, including a head portion, and a stem portion which projects from a lower surface of the head portion, the stem portion being inserted in an opening of a vial; wherein the stem portion is provided with a small diameter portion and a seal portion, in that order from the lower surface the head portion, the diameter of the small diameter portion being smaller than the diameter of the seal portion. The entirety of the small diameter portion and the seal portion are substantially uniformly fitted in the opening of the vial.[0009]
• Preferably, the following condition is satisfied:[0010]
• 0.80D≦d≦0.98D; wherein ‘d’ designates the diameter of the small diameter portion, and ‘D’ designates the diameter of the seal portion.[0011]
• Preferably, the stem portion is further provided with a leg portion connected to the seal portion, the leg portion being provided with at least one radial opening and a plurality of half-insertion projections formed on the outer peripheral surface of the seal portion, the diameter of the seal portion being smaller than the diameter of a circumscribed circle of the half-insertion projections.[0012]
• Preferably, the following condition is satisfied:[0013]
• S/5≧j≧S/20; wherein ‘j’ designates the axial length of the small diameter portion, and ‘S’ designates the axial length of the seal portion.[0014]
• The present disclosure relates to subject matter contained in Japanese Patent Application No.2000-254854 (filed on Aug. 25, 2000) which is expressly incorporated herein by reference in its entirety.[0015]
BRIEF DESCRIPTION OF THE INVENTION
• FIG. 1 is a partially sectioned perspective view of a closure for a vial, according to an embodiment of the present invention;[0016]
• FIG. 2 is a front elevational view of a closure for a vial shown in FIG. 1; and[0017]
• FIG. 3 is a back view of a closure for a vial shown in FIG. 1.[0018]
DESCRIPTION OF THE PREFERRED EMBODIMENT
• A[0019]closure10 for avial20 according to the present invention is composed of a head portion (top plate)11 in the form of a circular disc, and acylindrical stem portion12, which has a diameter smaller than that of thehead portion11 and which projects from the lower surface of thehead portion11. Thestem portion12 is fitted in an opening (bottle neck)21 of the vial (container for holding liquid medicament)20. Thehead portion11 is in contact with anend face22 of the opening21.
• The[0020]stem portion12 is provided with aseal portion13 adjacent to thehead portion11 and aleg portion14 connected to theseal portion13. Theseal portion13 is provided on its end adjacent to thehead portion11, with asmall diameter portion15 having a smaller diameter. Theseal portion13 has a uniform diameter D which is slightly greater than the uniform inner diameter x of the opening21 of thevial20, so that when the stem portion is inserted in theopening21, theseal portion13 is uniformly compressed to establish a press fit therebetween. There is no sealing annular projection or other projection provided on theclosure10, unlike a conventional closure for a vial. In an alternative embodiment, theseal portion13 can be provided with a slightly tapered peripheral surface.
• The diameter d and axial length (width) j of the[0021]small diameter portion15 are determined, taking into account a difference in the diameter between theseal portion13 and theopening21, so that when theseal portion13 is fitted in theopening21 of thevial20, the material of the portion of theseal portion13 that is compressed and deformed is moved into thesmall diameter portion15 so that no force is produced which would cause theclosure10 to disengage from thevial20. More specifically, the diameter d of thesmall diameter portion15 is preferably in the range of d=0.80D to 0.98D (0.80D≦d≦0.98D), wherein D is the diameter of theseal portion13. The axial length j of theseal portion15 is preferably in the range of j={{fraction (1/5)} through {fraction (1/20)}}*S (i.e., S/5≧j≧S/20), wherein S is the axial length of theseal portion13. By way of example, in theclosure10 constructed as above, the diameter of thehead portion11 is in the range of 10 mm through 30 mm and the overall length of thestem portion12 is in the range of 5 mm through 30 mm.
• The[0022]leg portion14 of thestem portion12 is provided with aradial opening16 through which cleaning liquid can easily enter thestem portion12. Theleg portion14 is provided on its outer peripheral surface with a plurality of half-insertion projections17 (three projections in the illustrated in FIG. 2) at an equal angular distance. When thestem portion12 of theclosure10 is inserted in theopening21 of thevial20, theprojections17 first engage with the inner peripheral surface of theopening21 to provisionally hold theclosure10 while keeping the posture thereof before theclosure10 is completely inserted in thevial20. The outer diameter D of theseal portion13 is smaller than a diameter t of a circumscribed circle to theprojections17. If the diameter D were substantially identical to the diameter t, it would be impossible to completely insert theclosure10 in thevial20. If the diametert of the circumscribed circle is larger than the outer diameter D, the stem portion can be easily deformed due to the presence of theopening16, so that theclosure10 can be half-inserted easily. The opening16 and theprojections17 can be appropriately increased in number.
• The[0023]closure10 is forced (press-fitted) into the opening21 of thevial20, after thevial20 is filled with liquid medicament. Upon theclosure10 being press-fitted into thevial20, theleg portion14 of thestem portion12 is elastically deformed and is inserted in theopening21. Consequently, theprojections17, provided on the outer peripheral surface of thestem portion14, are frictionally engaged with the inner surface of the opening21 of thevial20 to establish a provisional holding (half-insertion state). Thereafter, when theclosure10 is further inserted into theopening21, theseal portion13 is pressed onto and brought into uniform surface contact with the inner peripheral surface of theopening21 of thevial20, so that the lower surface (under surface) of thehead portion11 comes into contact with theend face22 of theopening21. Thus, the complete insertion of theclosure10 into thevial20 is obtained. In this state, the material of the portion of theseal portion13 is partly moved into and received in thesmall diameter portion15. Hence, there is no or little possibility that the elastic deformation of theseal portion13 causes theclosure10 to slip off from thevial20.
• As can be understood from the above discussion, according to the present invention, the stem portion of the closure for a vial is provided, on the portion thereof adjacent to the head portion, with a seal portion that is entirely fitted in and brought into close surface-contact with the inner surface of the opening of the vial, and the seal portion is provided on an end thereof adjacent to the head portion with a small diameter portion whose diameter is smaller than the diameter of the main body of the seal portion. According to this construction, no slipping force is applied to the closure when the closure is fitted in the vial.[0024]
• Obvious changes may be made in the specific embodiments of the present invention described herein, such modifications being within the spirit and scope of the invention claimed. It is indicated that all matter contained herein is illustrative and does not limit the scope of the present invention.[0025]

Claims (4)

What is claimed is:

1. A closure for a vial comprising:

a head portion; and

a stem portion which projects from a lower surface of the head portion, said stem portion being inserted in an opening of a vial;

wherein said stem portion is provided with a small diameter portion and a seal portion, in that order from said lower surface the head portion, the diameter of said small diameter portion being smaller than the diameter of the seal portion;

and wherein the entirety of said small diameter portion and said seal portion are substantially uniformly fitted in the opening of the vial.

2. The closure for a vial according toclaim 1, wherein the following condition is satisfied:

0.80D≦d≦0.98D;

wherein

d designates the diameter of the small diameter portion; and

D designates the diameter of the seal portion.

3. The closure for a vial according toclaim 1, wherein the stem portion is further provided with a leg portion connected to the seal portion, said leg portion being provided with at least one radial opening and a plurality of half-insertion projections formed on the outer peripheral surface of the seal portion, the diameter of the seal portion being smaller than the diameter of a circumscribed circle of the half-insertion projections.

4. The closure for a vial according toclaim 1, wherein the following condition is satisfied:

S/5≧j≧S/20;

wherein

j designates the axial length of the small diameter portion; and

S designates the axial length of the seal portion.

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