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TW200626142A - Chemical compounds - Google Patents

Chemical compounds

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Publication number
TW200626142A
TW200626142ATW094132222ATW94132222ATW200626142ATW 200626142 ATW200626142 ATW 200626142ATW 094132222 ATW094132222 ATW 094132222ATW 94132222 ATW94132222 ATW 94132222ATW 200626142 ATW200626142 ATW 200626142A
Authority
TW
Taiwan
Prior art keywords
compound
directed
ikk2
treatment
activity
Prior art date
Application number
TW094132222A
Other languages
Chinese (zh)
Inventor
Jeffrey K Kerns
Michael Lindenmuth
Xichen Lin
Hong Nie
Sonia M Thomas
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group LtdfiledCriticalGlaxo Group Ltd
Publication of TW200626142ApublicationCriticalpatent/TW200626142A/en

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Abstract

The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula I: where R1, R2, R3, U and V are defined below and to pharmaceutically acceptable salts thereof. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKK β) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
TW094132222A2004-09-212005-09-19Chemical compoundsTW200626142A (en)

Applications Claiming Priority (2)

Application NumberPriority DateFiling DateTitle
US61176104P2004-09-212004-09-21
US69545405P2005-06-302005-06-30

Publications (1)

Publication NumberPublication Date
TW200626142Atrue TW200626142A (en)2006-08-01

Family

ID=36090636

Family Applications (1)

Application NumberTitlePriority DateFiling Date
TW094132222ATW200626142A (en)2004-09-212005-09-19Chemical compounds

Country Status (16)

CountryLink
US (1)US7858796B2 (en)
EP (1)EP1793826A4 (en)
JP (1)JP2008513500A (en)
KR (1)KR20070057969A (en)
AR (1)AR054084A1 (en)
AU (1)AU2005286795A1 (en)
BR (1)BRPI0515524A (en)
CA (1)CA2581180A1 (en)
IL (1)IL181877A0 (en)
MA (1)MA28912B1 (en)
MX (1)MX2007003283A (en)
NO (1)NO20071988L (en)
PE (1)PE20060748A1 (en)
SG (1)SG155932A1 (en)
TW (1)TW200626142A (en)
WO (1)WO2006034317A2 (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
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Also Published As

Publication numberPublication date
EP1793826A2 (en)2007-06-13
KR20070057969A (en)2007-06-07
AU2005286795A1 (en)2006-03-30
US7858796B2 (en)2010-12-28
WO2006034317A3 (en)2007-04-19
PE20060748A1 (en)2006-10-01
IL181877A0 (en)2007-07-04
MA28912B1 (en)2007-10-01
SG155932A1 (en)2009-10-29
MX2007003283A (en)2007-05-18
EP1793826A4 (en)2010-04-21
NO20071988L (en)2007-04-18
BRPI0515524A (en)2008-07-29
CA2581180A1 (en)2006-03-30
AR054084A1 (en)2007-06-06
US20070254873A1 (en)2007-11-01
JP2008513500A (en)2008-05-01
WO2006034317A2 (en)2006-03-30

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