| US861745A (en) | 1906-11-21 | 1907-07-30 | Jefferson D Maxwell | Hydraulic dredging apparatus. |
| US4475196A (en) | 1981-03-06 | 1984-10-02 | Zor Clair G | Instrument for locating faults in aircraft passenger reading light and attendant call control system |
| US4447233A (en) | 1981-04-10 | 1984-05-08 | Parker-Hannifin Corporation | Medication infusion pump |
| US4433059A (en) | 1981-09-08 | 1984-02-21 | Ortho Diagnostic Systems Inc. | Double antibody conjugate |
| US4444878A (en) | 1981-12-21 | 1984-04-24 | Boston Biomedical Research Institute, Inc. | Bispecific antibody determinants |
| US4439196A (en) | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4447224A (en) | 1982-09-20 | 1984-05-08 | Infusaid Corporation | Variable flow implantable infusion apparatus |
| US4487603A (en) | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4486194A (en) | 1983-06-08 | 1984-12-04 | James Ferrara | Therapeutic device for administering medicaments through the skin |
| WO1985000817A1 (en) | 1983-08-10 | 1985-02-28 | Amgen | Microbial expression of interleukin ii |
| JPS6147500A (en) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | Chimeric monoclonal antibody and its production method |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| JPS61134325A (en) | 1984-12-04 | 1986-06-21 | Teijin Ltd | Expression of hybrid antibody gene |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| US4737456A (en) | 1985-05-09 | 1988-04-12 | Syntex (U.S.A.) Inc. | Reducing interference in ligand-receptor binding assays |
| US5374548A (en) | 1986-05-02 | 1994-12-20 | Genentech, Inc. | Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor |
| MX9203291A (en) | 1985-06-26 | 1992-08-01 | Liposome Co Inc | LIPOSOMAS COUPLING METHOD. |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| EP0247091B1 (en) | 1985-11-01 | 1993-09-29 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
| US5869620A (en) | 1986-09-02 | 1999-02-09 | Enzon, Inc. | Multivalent antigen-binding proteins |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| EP0307434B2 (en) | 1987-03-18 | 1998-07-29 | Scotgen Biopharmaceuticals, Inc. | Altered antibodies |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US5770701A (en) | 1987-10-30 | 1998-06-23 | American Cyanamid Company | Process for preparing targeted forms of methyltrithio antitumor agents |
| US5606040A (en) | 1987-10-30 | 1997-02-25 | American Cyanamid Company | Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group |
| US5057423A (en) | 1987-12-18 | 1991-10-15 | University Of Pittsburgh | Method for the preparation of pure LAK-active lymphocytes |
| US5731116A (en) | 1989-05-17 | 1998-03-24 | Dai Nippon Printing Co., Ltd. | Electrostatic information recording medium and electrostatic information recording and reproducing method |
| JPH021556A (en) | 1988-06-09 | 1990-01-05 | Snow Brand Milk Prod Co Ltd | Hybrid antibody and production thereof |
| EP1541682A3 (en) | 1988-09-02 | 2005-07-06 | Dyax Corp. | Generation and selection of recombinant varied binding proteins |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| FI903489A7 (en) | 1988-11-11 | 1990-07-10 | Medical Res Council | Ligands containing one moiety, receptors containing these ligands, methods for their preparation and uses of the ligands and receptors |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US6905680B2 (en) | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
| US5766947A (en) | 1988-12-14 | 1998-06-16 | Astra Ab | Monoclonal antibodies reactive with an epitope of a Vβ3.1 variable region of a T cell receptor |
| US5223426A (en) | 1988-12-15 | 1993-06-29 | T Cell Sciences, Inc. | Monoclonal antibodies reactive with defined regions of the t-cell antigen receptor |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5116615A (en) | 1989-01-27 | 1992-05-26 | Immunolytics, Inc. | Method for treating benign prostatic hypertrophy |
| GB8905669D0 (en) | 1989-03-13 | 1989-04-26 | Celltech Ltd | Modified antibodies |
| US5108921A (en) | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| US6291158B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertoire |
| CA2018248A1 (en) | 1989-06-07 | 1990-12-07 | Clyde W. Shearman | Monoclonal antibodies against the human alpha/beta t-cell receptor, their production and use |
| DE3920358A1 (en) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | BISPECIFIC AND OLIGO-SPECIFIC, MONO- AND OLIGOVALENT ANTI-BODY CONSTRUCTS, THEIR PRODUCTION AND USE |
| WO1991000906A1 (en) | 1989-07-12 | 1991-01-24 | Genetics Institute, Inc. | Chimeric and transgenic animals capable of producing human antibodies |
| AU6290090A (en) | 1989-08-29 | 1991-04-08 | University Of Southampton | Bi-or trispecific (fab)3 or (fab)4 conjugates |
| CA2026147C (en) | 1989-10-25 | 2006-02-07 | Ravi J. Chari | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US5959177A (en) | 1989-10-27 | 1999-09-28 | The Scripps Research Institute | Transgenic plants expressing assembled secretory antibodies |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| DK0463151T3 (en) | 1990-01-12 | 1996-07-01 | Cell Genesys Inc | Generation of xenogenic antibodies |
| US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5273743A (en) | 1990-03-09 | 1993-12-28 | Hybritech Incorporated | Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9012995D0 (en) | 1990-06-11 | 1990-08-01 | Celltech Ltd | Multivalent antigen-binding proteins |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| WO1992020791A1 (en) | 1990-07-10 | 1992-11-26 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| ATE352612T1 (en) | 1990-08-29 | 2007-02-15 | Pharming Intellectual Pty Bv | HOMOLOGOUS RECOMBINATION IN MAMMAL CELLS |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| KR100272077B1 (en) | 1990-08-29 | 2000-11-15 | 젠팜인터내셔날,인코포레이티드 | Transgenic non-human animals capable of producing heterologous antibodies |
| GB9022788D0 (en) | 1990-10-19 | 1990-12-05 | Cortecs Ltd | Pharmaceutical formulations |
| ES2113940T3 (en) | 1990-12-03 | 1998-05-16 | Genentech Inc | ENRICHMENT METHOD FOR PROTEIN VARIANTS WITH ALTERED UNION PROPERTIES. |
| US5582996A (en) | 1990-12-04 | 1996-12-10 | The Wistar Institute Of Anatomy & Biology | Bifunctional antibodies and method of preparing same |
| US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
| EP0575485A1 (en) | 1991-03-01 | 1993-12-29 | Dyax Corp. | Process for the development of binding mini-proteins |
| DE69233750D1 (en) | 1991-04-10 | 2009-01-02 | Scripps Research Inst | Libraries of heterodimeric receptors using phagemids |
| DE69233482T2 (en) | 1991-05-17 | 2006-01-12 | Merck & Co., Inc. | Method for reducing the immunogenicity of antibody variable domains |
| DE4118120A1 (en) | 1991-06-03 | 1992-12-10 | Behringwerke Ag | TETRAVALENT BISPECIFIC RECEPTORS, THEIR PRODUCTION AND USE |
| US6511663B1 (en) | 1991-06-11 | 2003-01-28 | Celltech R&D Limited | Tri- and tetra-valent monospecific antigen-binding proteins |
| US6407213B1 (en) | 1991-06-14 | 2002-06-18 | Genentech, Inc. | Method for making humanized antibodies |
| US5637481A (en) | 1993-02-01 | 1997-06-10 | Bristol-Myers Squibb Company | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell |
| DE4122599C2 (en) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid for screening antibodies |
| GB9114948D0 (en) | 1991-07-11 | 1991-08-28 | Pfizer Ltd | Process for preparing sertraline intermediates |
| US5747036A (en) | 1991-08-28 | 1998-05-05 | Brigham & Women's Hospital | Methods and compositions for detecting and treating a subset of human patients having an autoimmune disease |
| EP0604580A1 (en) | 1991-09-19 | 1994-07-06 | Genentech, Inc. | EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab') 2? ANTIBODIES |
| FI941572L (en) | 1991-10-07 | 1994-05-27 | Oncologix Inc | Combination and method of use of anti-erbB-2 monoclonal antibodies |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| ATE207080T1 (en) | 1991-11-25 | 2001-11-15 | Enzon Inc | MULTIVALENT ANTIGEN-BINDING PROTEINS |
| US5932448A (en) | 1991-11-29 | 1999-08-03 | Protein Design Labs., Inc. | Bispecific antibody heterodimers |
| ES2227512T3 (en) | 1991-12-02 | 2005-04-01 | Medical Research Council | PRODUCTION OF ANTIBODIES AGAINST SELF-ANTIGENS FROM REPERTORIES OF ANTIBODY SEGMENTS FIXED IN A PHOTO. |
| CA2124460C (en) | 1991-12-02 | 2007-08-28 | Andrew David Griffiths | Production of anti-self antibodies from segment repertoires and displayed on phage |
| GB9125768D0 (en) | 1991-12-04 | 1992-02-05 | Hale Geoffrey | Therapeutic method |
| JP3490437B2 (en) | 1992-01-23 | 2004-01-26 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | Monomeric and dimeric antibody fragment fusion proteins |
| EP0625200B1 (en) | 1992-02-06 | 2005-05-11 | Chiron Corporation | Biosynthetic binding protein for cancer marker |
| WO1993023537A1 (en) | 1992-05-08 | 1993-11-25 | Creative Biomolecules | Chimeric multivalent protein analogues and methods of use thereof |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| ATE452975T1 (en) | 1992-08-21 | 2010-01-15 | Univ Bruxelles | IMMUNOGLOBULINS WITHOUT LIGHT CHAINS |
| US6005079A (en) | 1992-08-21 | 1999-12-21 | Vrije Universiteit Brussels | Immunoglobulins devoid of light chains |
| US6765087B1 (en) | 1992-08-21 | 2004-07-20 | Vrije Universiteit Brussel | Immunoglobulins devoid of light chains |
| WO1994007921A1 (en) | 1992-09-25 | 1994-04-14 | Commonwealth Scientific And Industrial Research Organisation | Target binding polypeptide |
| EP0669987B1 (en) | 1992-09-25 | 2008-08-13 | Aventis Pharma S.A. | Adenovirus vectors for the transfer of foreign genes into cells of the central nervous system, particularly in brain |
| GB9221657D0 (en) | 1992-10-15 | 1992-11-25 | Scotgen Ltd | Recombinant bispecific antibodies |
| CA2126967A1 (en) | 1992-11-04 | 1994-05-11 | Anna M. Wu | Novel antibody construct |
| EP0752248B1 (en) | 1992-11-13 | 2000-09-27 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| GB9323648D0 (en) | 1992-11-23 | 1994-01-05 | Zeneca Ltd | Proteins |
| US5635483A (en) | 1992-12-03 | 1997-06-03 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Tumor inhibiting tetrapeptide bearing modified phenethyl amides |
| AU690528B2 (en) | 1992-12-04 | 1998-04-30 | Medical Research Council | Multivalent and multispecific binding proteins, their manufacture and use |
| US5780588A (en) | 1993-01-26 | 1998-07-14 | Arizona Board Of Regents | Elucidation and synthesis of selected pentapeptides |
| WO1994025591A1 (en) | 1993-04-29 | 1994-11-10 | Unilever N.V. | PRODUCTION OF ANTIBODIES OR (FUNCTIONALIZED) FRAGMENTS THEREOF DERIVED FROM HEAVY CHAIN IMMUNOGLOBULINS OF $i(CAMELIDAE) |
| JPH0787994A (en) | 1993-04-30 | 1995-04-04 | Sumitomo Electric Ind Ltd | Monoclonal antibody against T cell antigen receptor Vβ22 and method for producing the same |
| JPH08511420A (en) | 1993-06-16 | 1996-12-03 | セルテック・セラピューテイクス・リミテッド | Body |
| US6476198B1 (en) | 1993-07-13 | 2002-11-05 | The Scripps Research Institute | Multispecific and multivalent antigen-binding polypeptide molecules |
| CA2147626C (en) | 1993-08-10 | 1998-04-21 | Mark D. Butler | Cell encapsulating device |
| US5635602A (en) | 1993-08-13 | 1997-06-03 | The Regents Of The University Of California | Design and synthesis of bispecific DNA-antibody conjugates |
| WO1995009917A1 (en) | 1993-10-07 | 1995-04-13 | The Regents Of The University Of California | Genetically engineered bispecific tetravalent antibodies |
| GB9325182D0 (en) | 1993-12-08 | 1994-02-09 | T Cell Sciences Inc | Humanized antibodies or binding proteins thereof specific for t cell subpopulations exhibiting select beta chain variable regions |
| SE9400088D0 (en) | 1994-01-14 | 1994-01-14 | Kabi Pharmacia Ab | Bacterial receptor structures |
| US5773001A (en) | 1994-06-03 | 1998-06-30 | American Cyanamid Company | Conjugates of methyltrithio antitumor agents and intermediates for their synthesis |
| US5968753A (en) | 1994-06-14 | 1999-10-19 | Nexell Therapeutics, Inc. | Positive and positive/negative cell selection mediated by peptide release |
| EP0787185A2 (en) | 1994-10-20 | 1997-08-06 | MorphoSys AG | Targeted hetero-association of recombinant proteins to multi-functional complexes |
| US5789199A (en) | 1994-11-03 | 1998-08-04 | Genentech, Inc. | Process for bacterial production of polypeptides |
| FR2727867B1 (en) | 1994-12-13 | 1997-01-31 | Rhone Poulenc Rorer Sa | GENE TRANSFER IN MEDULLAR MOTONURONES USING ADENOVIRAL VECTORS |
| AU712441B2 (en) | 1994-12-14 | 1999-11-04 | Scripps Research Institute, The | In vivo activation of tumor-specific cytotoxic T cells |
| US5840523A (en) | 1995-03-01 | 1998-11-24 | Genetech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| EP0827544B1 (en) | 1995-05-23 | 2004-08-18 | MorphoSys AG | Multimeric proteins |
| US5626561A (en) | 1995-06-07 | 1997-05-06 | Gore Hybrid Technologies, Inc. | Implantable containment apparatus for a therapeutical device and method for loading and reloading the device therein |
| US5714586A (en) | 1995-06-07 | 1998-02-03 | American Cyanamid Company | Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates |
| EP0773753B1 (en) | 1995-06-07 | 2003-10-08 | Gore Hybrid Technologies, Inc. | An implantable containment apparatus for a therapeutical device |
| US5712374A (en) | 1995-06-07 | 1998-01-27 | American Cyanamid Company | Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates |
| US5811097A (en) | 1995-07-25 | 1998-09-22 | The Regents Of The University Of California | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
| US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| AU6854696A (en) | 1995-09-22 | 1997-04-09 | Gore Hybrid Technologies, Inc. | Improved cell encapsulation device |
| WO1997014719A1 (en) | 1995-10-16 | 1997-04-24 | Unilever N.V. | A bifunctional or bivalent antibody fragment analogue |
| GB9603256D0 (en) | 1996-02-16 | 1996-04-17 | Wellcome Found | Antibodies |
| US5849589A (en) | 1996-03-11 | 1998-12-15 | Duke University | Culturing monocytes with IL-4, TNF-α and GM-CSF TO induce differentiation to dendric cells |
| EP0894135B1 (en) | 1996-04-04 | 2004-08-11 | Unilever Plc | Multivalent and multispecific antigen-binding protein |
| EP0871480A4 (en) | 1996-10-04 | 2001-04-04 | Univ Jefferson | T-LYMPHOCYTES TRIGGERING AN IMMUNE REACTION AND METHODS OF USE |
| JP2002505574A (en) | 1997-04-30 | 2002-02-19 | エンゾン,インコーポレイテッド | Polyalkylene oxide-modified single-chain polypeptides |
| US20030207346A1 (en) | 1997-05-02 | 2003-11-06 | William R. Arathoon | Method for making multispecific antibodies having heteromultimeric and common components |
| US20020062010A1 (en) | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| CA2304254C (en) | 1997-06-11 | 2012-05-22 | Hans Christian Thogersen | Trimerising module |
| DK0985039T3 (en) | 1997-06-12 | 2008-06-09 | Novartis Int Pharm Ltd | Artificial antibody polypeptides |
| US6171586B1 (en) | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
| WO1998058964A1 (en) | 1997-06-24 | 1998-12-30 | Genentech, Inc. | Methods and compositions for galactosylated glycoproteins |
| WO1999004820A2 (en) | 1997-07-21 | 1999-02-04 | Pharmacia & Upjohn Ab | Cytolysis of target cells by superantigen conjugates inducing t-cell activation |
| US6040498A (en) | 1998-08-11 | 2000-03-21 | North Caroline State University | Genetically engineered duckweed |
| DE19742706B4 (en) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | lipocalin muteins |
| GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
| BR9813276A (en) | 1997-10-27 | 2000-08-22 | Unilever Nv | Multivalent antigen binding protein, nucleotide sequences, expression vector, host cell, process for preparing multivalent antigen binding protein, and use thereof |
| DE69840412D1 (en) | 1997-10-31 | 2009-02-12 | Genentech Inc | METHODS AND COMPOSITIONS CONTAINING GLYCOPROTEIN GLYCOR FORMS |
| US6610833B1 (en) | 1997-11-24 | 2003-08-26 | The Institute For Human Genetics And Biochemistry | Monoclonal human natural antibodies |
| DK1034298T3 (en) | 1997-12-05 | 2012-01-30 | Scripps Research Inst | Humanization of murine antibody |
| ATE283364T1 (en) | 1998-01-23 | 2004-12-15 | Vlaams Interuniv Inst Biotech | MULTIPURPOSE ANTIBODIES DERIVATIVES |
| AUPP221098A0 (en) | 1998-03-06 | 1998-04-02 | Diatech Pty Ltd | V-like domain binding molecules |
| ES2292236T3 (en) | 1998-04-02 | 2008-03-01 | Genentech, Inc. | VARIATIONS OF ANTIBODIES AND THEIR FRAGMENTS. |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| HUP9900956A2 (en) | 1998-04-09 | 2002-04-29 | Aventis Pharma Deutschland Gmbh. | Single-chain multiple antigen-binding molecules, their preparation and use |
| WO1999054342A1 (en) | 1998-04-20 | 1999-10-28 | Pablo Umana | Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity |
| DE19819846B4 (en) | 1998-05-05 | 2016-11-24 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Multivalent antibody constructs |
| GB9812545D0 (en) | 1998-06-10 | 1998-08-05 | Celltech Therapeutics Ltd | Biological products |
| EP1100830B1 (en) | 1998-07-28 | 2003-10-01 | Micromet AG | Heterominibodies |
| US6333396B1 (en) | 1998-10-20 | 2001-12-25 | Enzon, Inc. | Method for targeted delivery of nucleic acids |
| US6818418B1 (en) | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
| PT1137941E (en) | 1998-12-10 | 2009-10-15 | Brystol Myers Squibb Company | Protein scaffolds for antibody mimics and other binding proteins |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| HUP0104865A3 (en) | 1999-01-15 | 2004-07-28 | Genentech Inc | Polypeptide variants with altered effector function |
| US20030095967A1 (en) | 1999-01-25 | 2003-05-22 | Mackay Fabienne | BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders |
| EP1163339A1 (en) | 1999-04-01 | 2001-12-19 | Innogenetics N.V. | A polypeptide structure for use as a scaffold |
| EP3031917A1 (en) | 1999-04-09 | 2016-06-15 | Kyowa Hakko Kirin Co., Ltd. | Method for controlling the activity of immunologically functional molecule |
| US7534866B2 (en) | 2005-10-19 | 2009-05-19 | Ibc Pharmaceuticals, Inc. | Methods and compositions for generating bioactive assemblies of increased complexity and uses |
| US7527787B2 (en) | 2005-10-19 | 2009-05-05 | Ibc Pharmaceuticals, Inc. | Multivalent immunoglobulin-based bioactive assemblies |
| DE19932688B4 (en) | 1999-07-13 | 2009-10-08 | Scil Proteins Gmbh | Design of beta-sheet proteins of gamma-II-crystalline antibody-like |
| BR0013391A (en) | 1999-08-17 | 2002-07-09 | Biogen Inc | Use of the baff receptor (bcma) as an immunoregulatory agent |
| US7125978B1 (en) | 1999-10-04 | 2006-10-24 | Medicago Inc. | Promoter for regulating expression of foreign genes |
| KR100797667B1 (en) | 1999-10-04 | 2008-01-23 | 메디카고 인코포레이티드 | How to regulate transcription of foreign genes |
| UA74798C2 (en) | 1999-10-06 | 2006-02-15 | Байоджен Айдек Ма Інк. | Method for treating cancer in mammals using polypeptide interfering with interaction between april and its receptors |
| EP1229125A4 (en) | 1999-10-19 | 2005-06-01 | Kyowa Hakko Kogyo Kk | PROCESS FOR PRODUCING A POLYPEPTIDE |
| US6979546B2 (en) | 1999-11-15 | 2005-12-27 | Universita Di Genova | Triggering receptor involved in natural cytotoxicity mediated by human natural killer cells and antibodies that identify the same |
| ATE423848T1 (en) | 1999-11-15 | 2009-03-15 | Innate Pharma | TRIGGER RECEPTOR INVOLVED IN THE NATURAL CYTOTOXICITY OF HUMAN NATURAL KILLER CELLS AND ANTIBODIES THAT IDENTIFY THIS RECEPTOR |
| US7105149B1 (en) | 1999-11-29 | 2006-09-12 | The Trustees Of Columbia University In The City Of New York | Isolation of five novel genes coding for new Fc receptors-type melanoma involved in the pathogenesis of lymphoma/myeloma |
| JP2003516755A (en) | 1999-12-15 | 2003-05-20 | ジェネンテック・インコーポレーテッド | Shotgun scanning, a combined method for mapping functional protein epitopes |
| NZ518764A (en) | 1999-12-29 | 2004-02-27 | Immunogen Inc | Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use |
| WO2001053354A2 (en) | 2000-01-20 | 2001-07-26 | Chiron Corporation | Methods for treating tumors using a fusion protein comprising il-2- polypeptides and p185-specific binding molecules |
| US20040002068A1 (en) | 2000-03-01 | 2004-01-01 | Corixa Corporation | Compositions and methods for the detection, diagnosis and therapy of hematological malignancies |
| KR20020093029A (en) | 2000-04-11 | 2002-12-12 | 제넨테크, 인크. | Multivalent Antibodies And Uses Therefor |
| WO2001090192A2 (en) | 2000-05-24 | 2001-11-29 | Imclone Systems Incorporated | Bispecific immunoglobulin-like antigen binding proteins and method of production |
| PT1297017E (en) | 2000-06-19 | 2012-09-04 | Gen Hospital Corp | COMPOSITIONS AND METHODS OF MONOCLONAL AND POLYCLONAL ANTIBODIES SPECIFIC TO T-CELL SUBPOPULATIONS |
| CA2410551A1 (en) | 2000-06-30 | 2002-01-10 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw (Vib) | Heterodimeric fusion proteins |
| IL137419A0 (en) | 2000-07-20 | 2001-07-24 | Yissum Res Dev Co | Nk cells activating receptors and their therapeutic and diagnostic uses |
| CA2417185A1 (en) | 2000-07-25 | 2002-01-31 | Shui-On Leung | Multivalent target binding protein |
| EA013563B1 (en) | 2000-10-06 | 2010-06-30 | Киова Хакко Кирин Ко., Лтд. | A transgenic non-human animal, producing antibodies with modified sugar chains, a process for producing antibodies composition and a medicament comprising the antibodies |
| US7064191B2 (en) | 2000-10-06 | 2006-06-20 | Kyowa Hakko Kogyo Co., Ltd. | Process for purifying antibody |
| US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
| CN1308447C (en) | 2000-10-20 | 2007-04-04 | 中外制药株式会社 | Low molecular weight agonist antibody |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| ES2405944T3 (en) | 2000-11-30 | 2013-06-04 | Medarex, Inc. | Nucleic acids encoding reorganized human immunoglobulin sequences from transgenic transchromosomal micezadas |
| US7829084B2 (en) | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
| CA2440358C (en) | 2001-03-05 | 2013-08-20 | Wangxia Wang | Denaturant stable and/or protease resistant, chaperone-like oligomeric proteins, polynucleotides encoding same and their uses |
| AU2002247826A1 (en) | 2001-03-13 | 2002-09-24 | University College London | Specific binding members |
| US20040175756A1 (en) | 2001-04-26 | 2004-09-09 | Avidia Research Institute | Methods for using combinatorial libraries of monomer domains |
| US20050048512A1 (en) | 2001-04-26 | 2005-03-03 | Avidia Research Institute | Combinatorial libraries of monomer domains |
| US20050053973A1 (en) | 2001-04-26 | 2005-03-10 | Avidia Research Institute | Novel proteins with targeted binding |
| ES2437875T3 (en) | 2001-04-30 | 2014-01-14 | Eli Lilly And Company | Humanized antibodies that recognize the beta-amyloid peptide |
| EP1399484B1 (en) | 2001-06-28 | 2010-08-11 | Domantis Limited | Dual-specific ligand and its use |
| US6833441B2 (en) | 2001-08-01 | 2004-12-21 | Abmaxis, Inc. | Compositions and methods for generating chimeric heteromultimers |
| NZ592087A (en) | 2001-08-03 | 2012-11-30 | Roche Glycart Ag | Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity |
| EP2281837B1 (en) | 2001-08-10 | 2016-10-05 | Aberdeen University | Antigen binding domains from fish |
| ES2276735T3 (en) | 2001-09-14 | 2007-07-01 | Affimed Therapeutics Ag | SINGLE CHAIN MULTIMERIC FV ANTIBODIES IN TANDEM. |
| US7084257B2 (en)* | 2001-10-05 | 2006-08-01 | Amgen Inc. | Fully human antibody Fab fragments with human interferon-gamma neutralizing activity |
| PL213948B1 (en) | 2001-10-25 | 2013-05-31 | Genentech Inc | Glycoprotein compositions |
| MXPA04005266A (en) | 2001-12-04 | 2004-10-11 | Merck Patent Gmbh | Immunocytokines with modulated selectivity. |
| US20030211078A1 (en) | 2001-12-07 | 2003-11-13 | Heavner George A. | Pseudo-antibody constructs |
| US20040093621A1 (en) | 2001-12-25 | 2004-05-13 | Kyowa Hakko Kogyo Co., Ltd | Antibody composition which specifically binds to CD20 |
| EP2359685B1 (en) | 2001-12-27 | 2013-12-04 | GlycoFi, Inc. | Methods to engineer mammalian-type carbohydrate structures |
| WO2003061570A2 (en) | 2002-01-16 | 2003-07-31 | Zyomyx, Inc. | Engineered binding proteins |
| AU2003221256A1 (en) | 2002-02-21 | 2003-09-09 | Biogen Idec Ma Inc. | Use of bcma as an immunoregulatory agent |
| US20040018557A1 (en) | 2002-03-01 | 2004-01-29 | Immunomedics, Inc. | Bispecific antibody point mutations for enhancing rate of clearance |
| JPWO2003085119A1 (en) | 2002-04-09 | 2005-08-11 | 協和醗酵工業株式会社 | Method for enhancing binding activity of antibody composition to Fcγ receptor IIIa |
| ES2362419T3 (en) | 2002-04-09 | 2011-07-05 | Kyowa Hakko Kirin Co., Ltd. | CELLS WITH DEPRESSION OR DELETION OF THE ACTIVITY OF THE PROTEIN THAT PARTICIPATES IN THE TRANSPORT OF GDP-FUCOSA. |
| AU2003236015A1 (en) | 2002-04-09 | 2003-10-20 | Kyowa Hakko Kirin Co., Ltd. | Process for producing antibody composition |
| EP1502603A4 (en) | 2002-04-09 | 2006-12-13 | Kyowa Hakko Kogyo Kk | MEDICAMENT CONTAINING ANTIBODY COMPOSITION APPROPRIATE TO PATIENT SUFFERING FROM POLYMORPHISM FC gammma RIIIA |
| CA2481920A1 (en) | 2002-04-09 | 2003-10-16 | Kyowa Hakko Kogyo Co., Ltd. | Antibody composition-containing medicament |
| PL373256A1 (en) | 2002-04-09 | 2005-08-22 | Kyowa Hakko Kogyo Co, Ltd. | Cells with modified genome |
| EP1500665B1 (en) | 2002-04-15 | 2011-06-15 | Chugai Seiyaku Kabushiki Kaisha | METHODS FOR CONSTRUCTING scDb LIBRARIES |
| JP2006506954A (en) | 2002-04-29 | 2006-03-02 | ゲンパト77 ファーマコジェネティクス エージー | Novel antibodies that bind to TCR and TIRC7 and their use in therapy and diagnosis |
| US7829289B2 (en) | 2002-05-14 | 2010-11-09 | Institut National De La Sante Et De Recherche Medicale | T cell subpopulation regulating gut immunity |
| CA2488441C (en) | 2002-06-03 | 2015-01-27 | Genentech, Inc. | Synthetic antibody phage libraries |
| US7906118B2 (en) | 2005-04-06 | 2011-03-15 | Ibc Pharmaceuticals, Inc. | Modular method to prepare tetrameric cytokines with improved pharmacokinetics by the dock-and-lock (DNL) technology |
| ATE328906T1 (en) | 2002-06-28 | 2006-06-15 | Domantis Ltd | DUAL-SPECIFIC LIGANDS WITH INCREASED HALF-LIFE |
| CA2872136C (en) | 2002-07-18 | 2017-06-20 | Merus B.V. | Recombinant production of mixtures of antibodies |
| WO2004024927A1 (en) | 2002-09-12 | 2004-03-25 | Greenovation Biotech Gmbh | Protein production method |
| AU2003271904B2 (en) | 2002-10-09 | 2009-03-05 | Adaptimmune Limited | Single chain recombinant T cell receptors |
| US7361740B2 (en) | 2002-10-15 | 2008-04-22 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| WO2004053054A2 (en) | 2002-12-09 | 2004-06-24 | Natspears Ltd. | Nk cell receptor conjugates for treating malignancies |
| EP2301966A1 (en) | 2002-12-16 | 2011-03-30 | Genentech, Inc. | Immunoglobulin variants and uses thereof |
| US7781197B2 (en) | 2002-12-20 | 2010-08-24 | Greenovation Biotech Gmbh | Transformed bryophyte cell having disrupted endogenous alpha 1,3-fucosyl and beta 1,2-xylosyl transferase encoding nucleotide sequences for the production of heterologous glycosylated proteins |
| DE10261223A1 (en)* | 2002-12-20 | 2004-07-08 | MedInnova Gesellschaft für medizinische Innovationen aus akademischer Forschung mbH | Increasing the immune response through substances that influence the function of natural killer cells |
| US7488802B2 (en) | 2002-12-23 | 2009-02-10 | Wyeth | Antibodies against PD-1 |
| US20080063717A1 (en) | 2002-12-23 | 2008-03-13 | Innate Pharma, S.A.S. | Pharmaceutical Compositions Having an Effect on the Proliferation of Nk Cells and a Method Using the Same |
| GB0230203D0 (en) | 2002-12-27 | 2003-02-05 | Domantis Ltd | Fc fusion |
| JP2006523090A (en) | 2002-12-27 | 2006-10-12 | ドマンティス リミテッド | Bispecific single domain antibody specific for ligand and for ligand receptor |
| JP2006524039A (en) | 2003-01-09 | 2006-10-26 | マクロジェニクス,インコーポレーテッド | Identification and production of antibody containing mutant Fc region and use thereof |
| EP1585767A2 (en) | 2003-01-16 | 2005-10-19 | Genentech, Inc. | Synthetic antibody phage libraries |
| DE602004028337D1 (en) | 2003-01-22 | 2010-09-09 | Glycart Biotechnology Ag | FUSION CONSTRUCTS AND ITS USE IN ANTIBODY PRODUCTION WITH INCREASED FC RECEPTOR BINDING SAFFINITY AND EFFECTOR FUNCTION |
| US20060104968A1 (en) | 2003-03-05 | 2006-05-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases |
| US7871607B2 (en) | 2003-03-05 | 2011-01-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases |
| CN1942588B (en) | 2003-03-05 | 2013-06-12 | 海洋酶公司 | Soluble hyaluronidase glycoproteins (sHASEGP), methods for their preparation, their use and pharmaceutical compositions comprising them |
| GB0305702D0 (en) | 2003-03-12 | 2003-04-16 | Univ Birmingham | Bispecific antibodies |
| US7700317B2 (en) | 2003-03-28 | 2010-04-20 | Biogen Idec Ma Inc. | Truncated baff receptors |
| EP1618181B1 (en) | 2003-04-22 | 2014-10-15 | IBC Pharmaceuticals | Polyvalent protein complex |
| WO2005000901A2 (en) | 2003-05-09 | 2005-01-06 | Duke University | Cd20-specific antibodies and methods of employing same |
| WO2005028517A2 (en) | 2003-05-09 | 2005-03-31 | The General Hospital Corporation | SOLUBLE TGF-β TYPE III RECEPTOR FUSION PROTEINS |
| CA2525120C (en) | 2003-05-14 | 2013-04-30 | Domantis Limited | A process for recovering polypeptides that unfold reversibly from a polypeptide repertoire |
| US20070105105A1 (en) | 2003-05-23 | 2007-05-10 | Mount Sinai School Of Medicine Of New York University | Surrogate cell gene expression signatures for evaluating the physical state of a subject |
| DE10324447A1 (en) | 2003-05-28 | 2004-12-30 | Scil Proteins Gmbh | Generation of artificial binding proteins based on ubiquitin |
| EP2395016A3 (en) | 2003-05-30 | 2012-12-19 | Merus B.V. | Design and use of paired variable regions of specific binding molecules |
| WO2005000898A2 (en) | 2003-06-27 | 2005-01-06 | Biogen Idec Ma Inc. | Use of hydrophobic-interaction-chromatography or hinge-region modifications for the production of homogeneous antibody-solutions |
| ES2315664T3 (en) | 2003-06-30 | 2009-04-01 | Domantis Limited | SINGLE-DOMAIN ANTIBODIES (DAB) PEGILATED. |
| JP5026072B2 (en) | 2003-07-01 | 2012-09-12 | イミューノメディクス、インコーポレイテッド | Multispecific carrier of bispecific antibody |
| CA2532547C (en) | 2003-07-24 | 2020-02-25 | Innate Pharma | Methods and compositions for increasing the efficiency of therapeutic antibodies using nk cell potentiating compounds |
| US7696322B2 (en) | 2003-07-28 | 2010-04-13 | Catalent Pharma Solutions, Inc. | Fusion antibodies |
| US20080241884A1 (en) | 2003-10-08 | 2008-10-02 | Kenya Shitara | Fused Protein Composition |
| US20070134759A1 (en) | 2003-10-09 | 2007-06-14 | Harue Nishiya | Process for producing antibody composition by using rna inhibiting the function of alpha1,6-fucosyltransferase |
| KR20070001880A (en) | 2003-10-20 | 2007-01-04 | 바이오겐 아이덱 엠에이 인코포레이티드 | Therapeutic regimens for BΑFF antagonists |
| DE602004026470D1 (en) | 2003-11-05 | 2010-05-20 | Roche Glycart Ag | FC RECEPTOR AND EFFECTOR FUNCTION |
| EP3858387A1 (en) | 2003-11-06 | 2021-08-04 | Seagen Inc. | Monomethylvaline compounds capable of conjugation to ligands |
| JPWO2005053742A1 (en) | 2003-12-04 | 2007-06-28 | 協和醗酵工業株式会社 | Medicament containing antibody composition |
| US20050136051A1 (en) | 2003-12-22 | 2005-06-23 | Bernard Scallon | Methods for generating multimeric molecules |
| GB0329825D0 (en) | 2003-12-23 | 2004-01-28 | Celltech R&D Ltd | Biological products |
| US20050266425A1 (en) | 2003-12-31 | 2005-12-01 | Vaccinex, Inc. | Methods for producing and identifying multispecific antibodies |
| US8383575B2 (en) | 2004-01-30 | 2013-02-26 | Paul Scherrer Institut | (DI)barnase-barstar complexes |
| WO2006107617A2 (en) | 2005-04-06 | 2006-10-12 | Ibc Pharmaceuticals, Inc. | Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses |
| KR20060132006A (en) | 2004-03-23 | 2006-12-20 | 비오겐 아이덱 엠에이 아이엔씨. | Receptor Coupling Agents and Their Therapeutic Uses |
| CN1961003B (en) | 2004-03-31 | 2013-03-27 | 健泰科生物技术公司 | Humanized anti-TGF-beta antibodies |
| US7785903B2 (en) | 2004-04-09 | 2010-08-31 | Genentech, Inc. | Variable domain library and uses |
| PL1737891T3 (en) | 2004-04-13 | 2013-08-30 | Hoffmann La Roche | Anti-p-selectin antibodies |
| JP2008502322A (en) | 2004-04-30 | 2008-01-31 | イネイト・ファーマ | Compositions and methods for enhancing NK cell activity |
| JP2008502597A (en) | 2004-04-30 | 2008-01-31 | イネイト・ファーマ | Compositions and methods for treating immunoproliferative disorders such as NK-type LDGL |
| US7501121B2 (en) | 2004-06-17 | 2009-03-10 | Wyeth | IL-13 binding agents |
| US20060008844A1 (en) | 2004-06-17 | 2006-01-12 | Avidia Research Institute | c-Met kinase binding proteins |
| US8361794B2 (en) | 2004-06-29 | 2013-01-29 | Immunocore Limited | Cells expressing a modified T cell receptor |
| JP2008512352A (en) | 2004-07-17 | 2008-04-24 | イムクローン システムズ インコーポレイティド | Novel tetravalent bispecific antibody |
| NZ552485A (en) | 2004-08-05 | 2009-11-27 | Genentech Inc | Humanized anti-cmet antagonists |
| CA2577082A1 (en) | 2004-09-02 | 2006-03-16 | Genentech, Inc. | Heteromultimeric molecules |
| TWI309240B (en) | 2004-09-17 | 2009-05-01 | Hoffmann La Roche | Anti-ox40l antibodies |
| WO2006034488A2 (en) | 2004-09-23 | 2006-03-30 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
| CA2580796C (en) | 2004-09-24 | 2013-03-26 | Amgen Inc. | Modified fc molecules having peptides inserted in internal loop regions |
| WO2006039238A2 (en) | 2004-09-30 | 2006-04-13 | The Goverment Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Irta2 antibodies and methods of use |
| JO3000B1 (en) | 2004-10-20 | 2016-09-05 | Genentech Inc | Antibody Formulations. |
| ES2342964T3 (en) | 2004-12-09 | 2010-07-20 | Merck Patent Gmbh | VARIATIONS OF INTERLEUCINE-7 WITH REDUCED IMMUNOGENICITY. |
| KR20070115881A (en) | 2005-01-12 | 2007-12-06 | 메다렉스, 인코포레이티드 | AIArtie-2 antibody and uses thereof |
| CA2595959A1 (en) | 2005-01-27 | 2006-08-03 | Novartis Vaccines And Diagnostics, Inc. | Methods for treating renal cell carcinoma |
| CA2595682A1 (en) | 2005-01-31 | 2006-08-03 | Ablynx N.V. | Method for generating variable domain sequences of heavy chain antibodies |
| US7431380B1 (en) | 2005-02-24 | 2008-10-07 | Theodore Allen Buresh | Louver kit |
| WO2006106905A1 (en) | 2005-03-31 | 2006-10-12 | Chugai Seiyaku Kabushiki Kaisha | Process for production of polypeptide by regulation of assembly |
| EP3479844B1 (en) | 2005-04-15 | 2023-11-22 | MacroGenics, Inc. | Covalent diabodies and uses thereof |
| KR20080013878A (en) | 2005-04-18 | 2008-02-13 | 노보 노르디스크 에이/에스 | IL-21 variants |
| CA3151350A1 (en) | 2005-05-09 | 2006-11-16 | E. R. Squibb & Sons, L.L.C. | Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics |
| US20060263367A1 (en) | 2005-05-23 | 2006-11-23 | Fey Georg H | Bispecific antibody devoid of Fc region and method of treatment using same |
| WO2006135886A2 (en) | 2005-06-13 | 2006-12-21 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| JP2006345852A (en) | 2005-06-16 | 2006-12-28 | Virxsys Corp | Antibody conjugate |
| CN103145838A (en) | 2005-06-30 | 2013-06-12 | Abbvie公司 | IL-12/p40 binding proteins |
| CA3201163A1 (en) | 2005-07-01 | 2007-01-11 | E. R. Squibb & Sons, L.L.C. | Human monoclonal antibodies to programmed death ligand 1 (pd-l1) |
| DK1917029T3 (en) | 2005-07-27 | 2013-04-29 | Lilly Co Eli | Process for treating cancer cells and creating a modified cancer cell that provokes an immunogenic response |
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| DE602005018477D1 (en) | 2005-08-26 | 2010-02-04 | Pls Design Gmbh | Bivalent IgY antibody constructs for diagnostic and therapeutic applications |
| WO2007027714A2 (en) | 2005-08-31 | 2007-03-08 | Schering Corporation | Engineered anti-il-23 antibodies |
| WO2007039507A2 (en) | 2005-09-23 | 2007-04-12 | Novo Nordisk A/S | Methods of identifying antibodies to ligands of orphan receptors |
| WO2007044887A2 (en) | 2005-10-11 | 2007-04-19 | Transtarget, Inc. | Method for producing a population of homogenous tetravalent bispecific antibodies |
| CA2625222A1 (en) | 2005-10-11 | 2007-04-19 | Domantis Limited | Antibody polypeptide library screening and selected antibody polypeptides |
| US8617545B2 (en) | 2005-10-13 | 2013-12-31 | Biogen Idec Ma Inc. | Methods for use with BAFF antagonists |
| US9447185B2 (en) | 2005-10-14 | 2016-09-20 | Innate Pharma, S.A. | Compositions and methods for treating proliferative disorders |
| US20080299137A1 (en) | 2005-10-28 | 2008-12-04 | Novo Nordisk A/S | Fusion Proteins That Bind Effector Lymphocytes And Target Cells |
| ES2577292T3 (en) | 2005-11-07 | 2016-07-14 | Genentech, Inc. | Binding polypeptides with diversified VH / VL hypervariable sequences and consensus |
| SG10201600950TA (en) | 2005-11-28 | 2016-03-30 | Genmab As | Recombinant monovalent antibodies and methods for production thereof |
| US8623356B2 (en) | 2005-11-29 | 2014-01-07 | The University Of Sydney | Demibodies: dimerization-activated therapeutic agents |
| US20070237764A1 (en) | 2005-12-02 | 2007-10-11 | Genentech, Inc. | Binding polypeptides with restricted diversity sequences |
| CA2638794A1 (en) | 2006-02-15 | 2007-08-23 | Imclone Systems Incorporated | Functional antibodies |
| JP2009529027A (en) | 2006-03-08 | 2009-08-13 | ビオメトード | Human interferon gamma (IFNγ) mutant |
| AU2007227292B2 (en) | 2006-03-17 | 2012-04-12 | Biogen Ma Inc. | Stabilized polypeptide compositions |
| WO2007112362A2 (en) | 2006-03-24 | 2007-10-04 | The Regents Of The University Of California | Construction of a multivalent scfv through alkyne-azide 1,3-dipolar cycloaddition |
| EP1999154B1 (en) | 2006-03-24 | 2012-10-24 | Merck Patent GmbH | Engineered heterodimeric protein domains |
| EP2009101B1 (en) | 2006-03-31 | 2017-10-25 | Chugai Seiyaku Kabushiki Kaisha | Antibody modification method for purifying bispecific antibody |
| JP2009536527A (en) | 2006-05-09 | 2009-10-15 | ジェネンテック・インコーポレーテッド | Binding polypeptide with optimized scaffold |
| EP2027153B1 (en) | 2006-05-25 | 2014-04-30 | Bayer Intellectual Property GmbH | Dimeric molecular complexes |
| US20070274985A1 (en) | 2006-05-26 | 2007-11-29 | Stefan Dubel | Antibody |
| EP3805269A1 (en) | 2006-06-12 | 2021-04-14 | Aptevo Research and Development LLC | Single-chain multivalent binding proteins with effector function |
| WO2008017859A2 (en) | 2006-08-10 | 2008-02-14 | Isis Innovation Limited | Ligand for the g6b receptor on blood platelets |
| WO2008073160A2 (en) | 2006-08-17 | 2008-06-19 | The Trustees Of Columbia University In The City Of New York | Methods for converting or inducing protective immunity |
| US8497246B2 (en) | 2006-08-18 | 2013-07-30 | Armagen Technologies, Inc. | Methods for diagnosing and treating CNS disorders by trans-blood-brain barrier delivery of protein compositions |
| WO2008027236A2 (en) | 2006-08-30 | 2008-03-06 | Genentech, Inc. | Multispecific antibodies |
| DK2069381T3 (en) | 2006-09-13 | 2016-03-14 | Univ Columbia | Anti-tumor immune response triggering agents and methods |
| CN101965363A (en) | 2006-11-02 | 2011-02-02 | 丹尼尔·J·卡鹏 | Hybrid immunoglobulin with active part |
| US20080226635A1 (en) | 2006-12-22 | 2008-09-18 | Hans Koll | Antibodies against insulin-like growth factor I receptor and uses thereof |
| WO2008087219A1 (en) | 2007-01-19 | 2008-07-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Compositions and methods for regulating t cell activity |
| ES2667863T3 (en) | 2007-03-29 | 2018-05-14 | Genmab A/S | Bispecific antibodies and their production methods |
| WO2008131242A1 (en) | 2007-04-18 | 2008-10-30 | Zymogenetics, Inc. | Single chain fc, methods of making and methods of treatment |
| PT2769984T (en) | 2007-05-11 | 2017-10-05 | Altor Bioscience Corp | MOLECULES OF FUSION AND VARIANTS OF IL-15 |
| WO2008144753A2 (en) | 2007-05-21 | 2008-11-27 | Alder Biopharmaceuticals, Inc. | Antibodies to tnf alpha and use thereof |
| CN100592373C (en) | 2007-05-25 | 2010-02-24 | 群康科技(深圳)有限公司 | Liquid crystal display panel driving device and driving method thereof |
| CN102131828B (en) | 2007-06-18 | 2015-06-17 | 默沙东有限责任公司 | Antibody against human programmed death receptor PD-1 |
| EP2014680A1 (en) | 2007-07-10 | 2009-01-14 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Recombinant, single-chain, trivalent tri-specific or bi-specific antibody derivatives |
| AU2008282218A1 (en) | 2007-07-31 | 2009-02-05 | Medimmune, Llc | Multispecific epitope binding proteins and uses thereof |
| EP2178914A2 (en) | 2007-08-15 | 2010-04-28 | Bayer Schering Pharma Aktiengesellschaft | Monospecific and multispecific antibodies and method of use |
| ES2566957T3 (en) | 2007-09-26 | 2016-04-18 | Chugai Seiyaku Kabushiki Kaisha | Constant region of modified antibody |
| JP5496897B2 (en) | 2007-10-04 | 2014-05-21 | ザイモジェネティクス, インコーポレイテッド | B7 family member zB7H6 and related compositions and methods |
| CA2705292C (en) | 2007-11-13 | 2016-06-21 | Teva Biopharmaceuticals Usa, Inc. | Humanized antibodies against tl1a |
| BRPI0819656A2 (en) | 2007-11-27 | 2015-06-23 | Ablynx Nv | Amino acid sequences against heterodimeric cytokines and / or their receptors and polypeptides comprising the same |
| CA2706419A1 (en) | 2007-11-30 | 2009-06-04 | Glaxo Group Limited | Antigen-binding constructs binding il-13 |
| KR20130087632A (en) | 2007-12-17 | 2013-08-06 | 화이자 리미티드 | Treatment of interstitial cystitis |
| US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
| US8227577B2 (en) | 2007-12-21 | 2012-07-24 | Hoffman-La Roche Inc. | Bivalent, bispecific antibodies |
| US8242247B2 (en) | 2007-12-21 | 2012-08-14 | Hoffmann-La Roche Inc. | Bivalent, bispecific antibodies |
| PL2235064T3 (en) | 2008-01-07 | 2016-06-30 | Amgen Inc | Method for making antibody fc-heterodimeric molecules using electrostatic steering effects |
| CN101970499B (en) | 2008-02-11 | 2014-12-31 | 治疗科技公司 | Monoclonal Antibodies for Cancer Therapy |
| CA2712474A1 (en) | 2008-02-21 | 2009-08-27 | Baxter Healthcare S.A. | Procedure for the generation of a high producer cell line for the expression of a recombinant anti-cd34 antibody |
| US8168757B2 (en) | 2008-03-12 | 2012-05-01 | Merck Sharp & Dohme Corp. | PD-1 binding proteins |
| WO2010031168A1 (en) | 2008-09-17 | 2010-03-25 | National Research Council Of Canada | HETERO-MULTIVALENT BINDING AGENTS FOR MEMBERS OF THE TGFβ SUPERFAMILY |
| CN107469077A (en) | 2008-04-11 | 2017-12-15 | 中外制药株式会社 | The antigen binding molecules combined repeatedly with the antigen of multiple molecules |
| EP2285980B1 (en) | 2008-06-02 | 2017-05-17 | Institut Gustave Roussy | NATURAL KILLER p30 (NKp30) DYSFUNCTION AND THE BIOLOGICAL APPLICATIONS THEREOF |
| AR072999A1 (en) | 2008-08-11 | 2010-10-06 | Medarex Inc | HUMAN ANTIBODIES THAT JOIN GEN 3 OF LYMPHOCYTARY ACTIVATION (LAG-3) AND THE USES OF THESE |
| US20110223188A1 (en) | 2008-08-25 | 2011-09-15 | Solomon Langermann | Targeted costimulatory polypeptides and methods of use to treat cancer |
| EP2927240A1 (en) | 2008-08-25 | 2015-10-07 | Amplimmune, Inc. | Compositions of pd-1 antagonists and methods of use |
| AU2009288354A1 (en) | 2008-08-26 | 2010-03-11 | Macrogenics Inc. | T-cell receptor antibodies and methods of use thereof |
| TWI516501B (en) | 2008-09-12 | 2016-01-11 | 禮納特神經系統科學公司 | Pcsk9 antagonists |
| PT4209510T (en) | 2008-12-09 | 2024-04-02 | Hoffmann La Roche | Anti-pd-l1 antibodies and their use to enhance t-cell function |
| US8580267B2 (en) | 2008-12-19 | 2013-11-12 | Philogen S.P.A. | Immunocytokines for tumour therapy with chemotherapeutic agents |
| EP3192811A1 (en) | 2009-02-09 | 2017-07-19 | Université d'Aix-Marseille | Pd-1 antibodies and pd-l1 antibodies and uses thereof |
| PL2406284T3 (en) | 2009-03-10 | 2017-09-29 | Biogen Ma Inc. | Anti-bcma antibodies |
| CN102369218B (en) | 2009-04-01 | 2014-07-16 | 霍夫曼-拉罗奇有限公司 | Anti-fcrh5 antibodies and immunoconjugates and methods of use |
| JP6132548B2 (en) | 2009-04-01 | 2017-05-24 | ジェネンテック, インコーポレイテッド | Anti-FcRH5 antibodies and immunoconjugates and methods of use |
| EP2414391B1 (en) | 2009-04-02 | 2018-11-28 | Roche Glycart AG | Multispecific antibodies comprising full length antibodies and single chain fab fragments |
| PT2417156E (en) | 2009-04-07 | 2015-04-29 | Roche Glycart Ag | Trivalent, bispecific antibodies |
| US9067986B2 (en) | 2009-04-27 | 2015-06-30 | Oncomed Pharmaceuticals, Inc. | Method for making heteromultimeric molecules |
| US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| US8703132B2 (en) | 2009-06-18 | 2014-04-22 | Hoffmann-La Roche, Inc. | Bispecific, tetravalent antigen binding proteins |
| PL2975051T3 (en) | 2009-06-26 | 2021-09-20 | Regeneron Pharmaceuticals, Inc. | Readily isolated bispecific antibodies with native immunoglobulin format |
| WO2011008502A2 (en) | 2009-06-29 | 2011-01-20 | California Institute Of Technology | Isolation of unknown rearranged t-cell receptors from single cells |
| WO2011020783A2 (en) | 2009-08-17 | 2011-02-24 | Roche Glycart Ag | Targeted immunoconjugates |
| CN102612524A (en) | 2009-09-01 | 2012-07-25 | 雅培制药有限公司 | Dual variable domain immunoglobulins and uses thereof |
| US9493578B2 (en) | 2009-09-02 | 2016-11-15 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
| IT1395574B1 (en) | 2009-09-14 | 2012-10-16 | Guala Dispensing Spa | DISTRIBUTION DEVICE |
| AU2010321720B2 (en) | 2009-11-23 | 2017-03-02 | Amgen Inc. | Monomeric antibody Fc |
| JP2013512251A (en) | 2009-11-24 | 2013-04-11 | アンプリミューン、インコーポレーテッド | Simultaneous inhibition of PD-L1 / PD-L2 |
| KR20120123299A (en) | 2009-12-04 | 2012-11-08 | 제넨테크, 인크. | Multispecific antibodies, antibody analogs, compositions, and methods |
| PT2510011E (en) | 2009-12-09 | 2014-12-12 | Inst Nat Santé Et De La Rech Médicale | Monoclonal antibodies that bind b7h6 and uses thereof |
| EA022984B1 (en) | 2009-12-29 | 2016-04-29 | Эмерджент Продакт Дивелопмент Сиэтл, Ллс | Ron binding constructs and methods of use thereof |
| US20130129723A1 (en) | 2009-12-29 | 2013-05-23 | Emergent Product Development Seattle, Llc | Heterodimer Binding Proteins and Uses Thereof |
| US20120294857A1 (en) | 2010-01-11 | 2012-11-22 | Trustees Of Dartmouth College | Monomeric Bi-Specific Fusion Protein |
| SI2530091T1 (en) | 2010-01-29 | 2018-06-29 | Chugai Seiyaku Kabushiki Kaisha | Anti-dll3 antibody |
| EP3798237A1 (en) | 2010-03-05 | 2021-03-31 | The Johns Hopkins University | Compositions and methods for targeted immunomodulatory antibodies and fusion proteins |
| AR080793A1 (en) | 2010-03-26 | 2012-05-09 | Roche Glycart Ag | BISPECIFIC ANTIBODIES |
| KR101930964B1 (en) | 2010-04-20 | 2018-12-19 | 젠맵 에이/에스 | Heterodimeric antibody fc-containing proteins and methods for production thereof |
| JP2013534520A (en) | 2010-06-08 | 2013-09-05 | ジェネンテック, インコーポレイテッド | Cysteine engineered antibodies and conjugates |
| PT2581113T (en) | 2010-06-11 | 2018-07-04 | Univ Kyushu Nat Univ Corp | Anti-tim-3 antibody |
| WO2012012737A2 (en) | 2010-07-23 | 2012-01-26 | The University Of Toledo | Stable tregs and related materials and methods |
| DK2606064T3 (en) | 2010-08-16 | 2015-04-20 | Novimmune Sa | Methods for generating multispecific and multivalent antibodies |
| CA2807278A1 (en) | 2010-08-24 | 2012-03-01 | F. Hoffmann - La Roche Ag | Bispecific antibodies comprising a disulfide stabilized - fv fragment |
| CN103068847B (en) | 2010-08-24 | 2019-05-07 | 罗切格利卡特公司 | Activatable Bispecific Antibodies |
| CN101985476B (en)* | 2010-10-29 | 2012-11-21 | 中国科学技术大学 | Preparation, identification and application of antihuman NKp30 monoclonal antibody |
| KR101973930B1 (en) | 2010-11-05 | 2019-04-29 | 자임워크스 인코포레이티드 | Stable heterodimeric antibody design with mutations in the fc domain |
| JP2014500879A (en) | 2010-11-16 | 2014-01-16 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Factors and methods for treating diseases correlated with BCMA expression |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| US20140271683A1 (en) | 2010-12-21 | 2014-09-18 | The Board Of Trustees Of The Leland Stanford Junior University | Therapeutic and Diagnostic Methods for Manipulating Phagocytosis Through Calreticulin and Low Density Lipoprotein-Related Receptor |
| EP2654792A4 (en) | 2010-12-22 | 2016-05-11 | Abbvie Inc | Half immunoglobulin binding proteins and uses thereof |
| US10689447B2 (en) | 2011-02-04 | 2020-06-23 | Genentech, Inc. | Fc variants and methods for their production |
| JP5878182B2 (en) | 2011-02-10 | 2016-03-08 | ロシュ グリクアート アーゲー | Mutant interleukin-2 polypeptide |
| WO2012118622A1 (en) | 2011-02-19 | 2012-09-07 | Baylor Research Institute | Diagnostic and therapeutic uses for b cell maturation antigen |
| WO2012118903A2 (en) | 2011-03-01 | 2012-09-07 | Amgen Inc. | Bispecific binding agents |
| EA201791693A1 (en) | 2011-03-25 | 2018-05-31 | Гленмарк Фармасьютикалс С.А. | HETERODIMERNY IMMUNOHLOBULINS |
| PT2694549T (en) | 2011-04-08 | 2018-11-22 | Us Health | Anti-epidermal growth factor receptor variant iii chimeric antigen receptors and use of same for the treatment of cancer |
| US20130101599A1 (en) | 2011-04-21 | 2013-04-25 | Boehringer Ingelheim International Gmbh | Bcma-based stratification and therapy for multiple myeloma patients |
| EA201892619A1 (en) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | IMMUNOCONJUGATES CONTAINING INTERLEUKIN-2 MUTANT POLYPETIPS |
| CN107903325B (en) | 2011-05-16 | 2021-10-29 | 埃泰美德(香港)有限公司 | Multispecific FAB fusion proteins and methods of use |
| US9574002B2 (en)* | 2011-06-06 | 2017-02-21 | Amgen Inc. | Human antigen binding proteins that bind to a complex comprising β-Klotho and an FGF receptor |
| CA2838340A1 (en) | 2011-06-17 | 2012-12-20 | Amgen Inc. | Method of treating or ameliorating metabolic disorders using clec-2 |
| EP3626739A1 (en) | 2011-06-24 | 2020-03-25 | Stephen D. Gillies | Light chain immunoglobulin fusion proteins and methods of use thereof |
| US9890218B2 (en) | 2011-06-30 | 2018-02-13 | Chugai Seiyaku Kabushiki Kaisha | Heterodimerized polypeptide |
| UA117901C2 (en) | 2011-07-06 | 2018-10-25 | Ґенмаб Б.В. | METHOD FOR STRENGTHENING THE EFFECTORAL FUNCTION OF THE ORIGINAL POLYEPEPTIDE, ITS OPTIONS AND THEIR APPLICATIONS |
| CN107266584B (en) | 2011-07-29 | 2022-05-13 | 宾夕法尼亚大学董事会 | Transducible co-stimulatory receptors |
| SI2748201T1 (en) | 2011-08-23 | 2018-03-30 | Roche Glycart Ag | Bispecific t cell activating antigen binding molecules |
| WO2013033626A2 (en)* | 2011-08-31 | 2013-03-07 | Trustees Of Dartmouth College | Nkp30 receptor targeted therapeutics |
| UY34317A (en) | 2011-09-12 | 2013-02-28 | Genzyme Corp | T cell antireceptor antibody (alpha) / ß |
| CA2791109C (en) | 2011-09-26 | 2021-02-16 | Merus B.V. | Generation of binding molecules |
| EP2768857B1 (en) | 2011-10-19 | 2020-01-01 | NovImmune SA | Methods of purifying antibodies |
| EA037797B1 (en) | 2011-10-25 | 2021-05-21 | Протена Байосайенсиз Лимитед | Antibody formulation useful for prophylaxis and treatment of amyloidosis, variants thereof and method of making same |
| JP6475017B2 (en) | 2011-10-27 | 2019-02-27 | ゲンマブ エー/エス | Production of heterodimeric protein |
| US20130273089A1 (en) | 2011-11-03 | 2013-10-17 | Tolera Therapeutics, Inc. | Antibody and methods for selective inhibition of t-cell responses |
| KR102052774B1 (en) | 2011-11-04 | 2019-12-04 | 자임워크스 인코포레이티드 | Stable heterodimeric antibody design with mutations in the fc domain |
| TWI679212B (en) | 2011-11-15 | 2019-12-11 | 美商安進股份有限公司 | Binding molecules for e3 of bcma and cd3 |
| AU2012344260B2 (en) | 2011-11-28 | 2017-09-07 | Merck Patent Gmbh | Anti-PD-L1 antibodies and uses thereof |
| CA2859767C (en) | 2011-12-19 | 2018-09-11 | Synimmune Gmbh | Bispecific antibody molecule and use thereof for treatment of proliferative disease |
| ES2816078T3 (en) | 2011-12-20 | 2021-03-31 | Medimmune Llc | Modified Polypeptides for Bispecific Antibody Scaffolds |
| AU2012362378B2 (en) | 2011-12-27 | 2016-06-23 | Dcb-Usa Llc | Light chain-bridged bispecific antibody |
| AU2013207407A1 (en) | 2012-01-05 | 2013-10-24 | Visa International Service Association | Transaction visual capturing apparatuses, methods and systems |
| RU2644341C2 (en) | 2012-02-10 | 2018-02-08 | Дженентек, Инк. | Single-chain antibodies and other heteromultimers |
| GB201203051D0 (en) | 2012-02-22 | 2012-04-04 | Ucb Pharma Sa | Biological products |
| JP6089047B2 (en) | 2012-02-24 | 2017-03-01 | アッヴィ・ステムセントルクス・エル・エル・シー | DLL3 modulator and method of use |
| PT2825559T (en) | 2012-03-13 | 2019-06-07 | Novimmune Sa | Readily isolated bispecific antibodies with native immunoglobulin format |
| MY198567A (en) | 2012-03-14 | 2023-09-05 | Regeneron Pharma | Multispecific antigen-binding molecules and uses thereof |
| CN114163530B (en) | 2012-04-20 | 2025-04-29 | 美勒斯公司 | Methods and means for producing immunoglobulin-like molecules |
| US20130336973A1 (en) | 2012-05-10 | 2013-12-19 | Zymeworks Inc. | Heteromultimer Constructs of Immunoglobulin Heavy Chains with Mutations in the Fc Domain |
| AU2013259276B2 (en) | 2012-05-10 | 2018-03-22 | Bioatla Llc | Multi-specific monoclonal antibodies |
| CA2869529A1 (en) | 2012-05-24 | 2013-11-28 | Raffaella CASTOLDI | Multispecific antibodies |
| WO2014004586A1 (en) | 2012-06-25 | 2014-01-03 | Zymeworks Inc. | Process and methods for efficient manufacturing of highly pure asymmetric antibodies in mammalian cells |
| CN104395340B9 (en) | 2012-06-27 | 2018-11-30 | 弗·哈夫曼-拉罗切有限公司 | Method of tailoring selective and multispecific therapeutic molecules comprising at least two different targeting entities and uses thereof |
| UY34887A (en) | 2012-07-02 | 2013-12-31 | Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware | OPTIMIZATION OF ANTIBODIES THAT FIX THE LYMPHOCYTE ACTIVATION GEN 3 (LAG-3) AND ITS USES |
| EP2869845B1 (en) | 2012-07-06 | 2019-08-28 | Genmab B.V. | Dimeric protein with triple mutations |
| CN104640561A (en) | 2012-07-23 | 2015-05-20 | 酵活有限公司 | Immunoglobulin constructs comprising selective pairing of light and heavy chains |
| CA2879814A1 (en) | 2012-08-02 | 2014-02-06 | Jn Biosciences Llc | Antibodies or fusion proteins multimerized via cysteine mutation and a mu tailpiece |
| WO2014022540A1 (en) | 2012-08-02 | 2014-02-06 | Regeneron Pharmaceuticals, Inc. | Multivalent antigen-binding proteins |
| ES2700978T3 (en) | 2012-08-07 | 2019-02-20 | Roche Glycart Ag | Composition comprising two antibodies engineered to have a reduced and increased effector function |
| US20140044675A1 (en) | 2012-08-10 | 2014-02-13 | Roche Glycart Ag | Interleukin-2 fusion proteins and uses thereof |
| US9682143B2 (en) | 2012-08-14 | 2017-06-20 | Ibc Pharmaceuticals, Inc. | Combination therapy for inducing immune response to disease |
| RU2663725C2 (en) | 2012-09-04 | 2018-08-08 | Селлектис | Multi-chain chimeric antigen receptor and uses thereof |
| US20140079691A1 (en) | 2012-09-20 | 2014-03-20 | Anaptysbio, Inc. | Thermostable antibody framework regions |
| US9771573B2 (en) | 2012-10-03 | 2017-09-26 | Zymeworks Inc. | Methods of quantitating heavy and light chain polypeptide pairs |
| US10087250B2 (en) | 2012-10-08 | 2018-10-02 | Roche Glycart Ag | Fc-free antibodies comprising two fab-fragments and methods of use |
| UY35148A (en) | 2012-11-21 | 2014-05-30 | Amgen Inc | HETERODIMERIC IMMUNOGLOBULINS |
| US9914785B2 (en) | 2012-11-28 | 2018-03-13 | Zymeworks Inc. | Engineered immunoglobulin heavy chain-light chain pairs and uses thereof |
| US9243058B2 (en) | 2012-12-07 | 2016-01-26 | Amgen, Inc. | BCMA antigen binding proteins |
| EP2934577A1 (en) | 2012-12-19 | 2015-10-28 | Adimab, LLC | Multivalent antibody analogs, and methods of their preparation and use |
| AU2013204922B2 (en) | 2012-12-20 | 2015-05-14 | Celgene Corporation | Chimeric antigen receptors |
| US9790277B2 (en) | 2012-12-21 | 2017-10-17 | The Johns Hopkins University | Anti-H7CR antibodies |
| US10766960B2 (en) | 2012-12-27 | 2020-09-08 | Chugai Seiyaku Kabushiki Kaisha | Heterodimerized polypeptide |
| JP6377635B2 (en) | 2013-01-10 | 2018-08-22 | ゲンマブ ビー.ブイ. | Human IgG1 Fc region variants and uses thereof |
| WO2014116846A2 (en) | 2013-01-23 | 2014-07-31 | Abbvie, Inc. | Methods and compositions for modulating an immune response |
| TWI682941B (en) | 2013-02-01 | 2020-01-21 | 美商再生元醫藥公司 | Antibodies comprising chimeric constant domains |
| ES2829499T3 (en) | 2013-02-05 | 2021-06-01 | Engmab Sarl | Method for the selection of antibodies against BCMA |
| US9989524B2 (en) | 2013-02-05 | 2018-06-05 | Sanofi | Immuno imaging agent for use with antibody-drug conjugate therapy |
| US10047163B2 (en) | 2013-02-08 | 2018-08-14 | Abbvie Stemcentrx Llc | Multispecific constructs |
| EP2954330A4 (en) | 2013-02-08 | 2016-08-31 | Inst Myeloma & Bone Cancer Res | Improved diagnostic, prognostic, and monitoring methods for multiple myeloma, chronic lymphocytic leukemia, and b-cell non-hodgkin lymphoma |
| GB201302447D0 (en) | 2013-02-12 | 2013-03-27 | Oxford Biotherapeutics Ltd | Therapeutic and diagnostic target |
| US9573988B2 (en) | 2013-02-20 | 2017-02-21 | Novartis Ag | Effective targeting of primary human leukemia using anti-CD123 chimeric antigen receptor engineered T cells |
| WO2014130879A2 (en) | 2013-02-22 | 2014-08-28 | Stem Centrx, Inc. | Novel antibody conjugates and uses thereof |
| EP2961773B1 (en) | 2013-02-26 | 2019-03-20 | Roche Glycart AG | Bispecific t cell activating antigen binding molecules |
| JP6420776B2 (en) | 2013-03-05 | 2018-11-07 | ベイラー カレッジ オブ メディスンBaylor College Of Medicine | Engager cells for immunotherapy |
| RS62304B1 (en) | 2013-03-14 | 2021-09-30 | Macrogenics Inc | BISPECIFIC MOLECULES WHICH ARE IMMUNOREACTIVE WITH IMMUNE EFFECTIVE CELLS EXPRESSING AN ACTIVATING RECEPTOR |
| AR095374A1 (en) | 2013-03-15 | 2015-10-14 | Amgen Res Munich Gmbh | UNION MOLECULES FOR BCMA AND CD3 |
| CN105007950B (en) | 2013-03-15 | 2019-01-15 | 诺华股份有限公司 | Antibody Drug Conjugates |
| US20140302037A1 (en) | 2013-03-15 | 2014-10-09 | Amgen Inc. | BISPECIFIC-Fc MOLECULES |
| US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
| US20140308285A1 (en) | 2013-03-15 | 2014-10-16 | Amgen Inc. | Heterodimeric bispecific antibodies |
| WO2014150973A1 (en) | 2013-03-15 | 2014-09-25 | Eli Lilly And Company | Methods for producing fabs and bi-specific antibodies |
| PL2992010T3 (en) | 2013-04-29 | 2021-08-23 | F.Hoffmann-La Roche Ag | Fc-receptor binding modified asymmetric antibodies and methods of use |
| CA2913363A1 (en) | 2013-05-24 | 2014-11-27 | Zymeworks Inc. | Modular protein drug conjugate therapeutic |
| BR112015029788B1 (en) | 2013-05-31 | 2024-01-02 | Zymeworks Inc | HETERO-MULTIMER, USE AND METHOD FOR PREPARING THE SAME, PHARMACEUTICAL COMPOSITION AND METHOD FOR REDUCING EFFECTOR FUNCTION OF AN IgG FC CONSTRUCT |
| AR096687A1 (en) | 2013-06-24 | 2016-01-27 | Genentech Inc | ANTI-FCRH5 ANTIBODIES |
| EP3019522B1 (en) | 2013-07-10 | 2017-12-13 | Sutro Biopharma, Inc. | Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use |
| EP3705498A1 (en) | 2013-08-22 | 2020-09-09 | Acceleron Pharma Inc. | Tgf-beta receptor type ii variants and uses thereof |
| DK2808338T3 (en) | 2013-09-16 | 2016-06-06 | Cemm - Forschungszentrum Für Molekulare Medizin Gmbh | Mutant calreticulin for diagnosis of myeloid malignancies |
| KR102441231B1 (en) | 2013-09-27 | 2022-09-06 | 추가이 세이야쿠 가부시키가이샤 | Method for preparing polypeptide heteromultimers |
| GB201317928D0 (en) | 2013-10-10 | 2013-11-27 | Ucl Business Plc | Molecule |
| EP3055329B1 (en) | 2013-10-11 | 2018-06-13 | F. Hoffmann-La Roche AG | Multispecific domain exchanged common variable light chain antibodies |
| AU2014342182B2 (en) | 2013-10-30 | 2020-05-14 | Eberhard Karls Universitat Tubingen | Methods for enhancing immunosuppressive therapy by multiple administration of alpha beta TCR -binding polypeptide |
| RS60443B1 (en) | 2013-12-17 | 2020-07-31 | Genentech Inc | Anti-cd3 antibodies and methods of use |
| EP3082853A2 (en) | 2013-12-20 | 2016-10-26 | The Broad Institute, Inc. | Combination therapy with neoantigen vaccine |
| MX380658B (en) | 2014-01-15 | 2025-03-11 | Hoffmann La Roche | REGION FC VARIANTS WITH ENHANCED PROTEIN A BINDING. |
| CA2931986A1 (en) | 2014-01-15 | 2015-07-23 | F. Hoffmann-La Roche Ag | Fc-region variants with modified fcrn- and maintained protein a-binding properties |
| CA2931979A1 (en) | 2014-01-15 | 2015-07-23 | F. Hoffmann-La Roche Ag | Fc-region variants with modified fcrn-binding properties |
| EP3508496A1 (en) | 2014-02-06 | 2019-07-10 | F. Hoffmann-La Roche AG | Interleukin-2 fusion proteins and uses thereof |
| US9676863B2 (en) | 2014-02-10 | 2017-06-13 | Merck Patent Gmbh | Targeted TGFβ inhibitors |
| DK3105252T3 (en) | 2014-02-12 | 2019-10-14 | Michael Uhlin | BISPECIFIC ANTIBODIES FOR USE IN STEM CELL TRANSPLANTATION |
| HK1231374A1 (en) | 2014-02-21 | 2017-12-22 | Regeneron Pharmaceuticals, Inc. | Methods, compositions and kits for cell specific modulation of target antigens |
| PE20161209A1 (en) | 2014-02-21 | 2016-11-10 | Abbvie Stemcentrx Llc | CONJUGATES OF ANTI-DROSOPHILA SIMILAR ANTIBODIES TO DELTA 3 (ANTI-DLL3) AND DRUGS FOR USE IN THE TREATMENT OF MELANOMA |
| DK3125934T3 (en) | 2014-03-05 | 2020-02-03 | Ucl Business Ltd | CHEMICAL ANTIGEN RECEPTOR (CAR) WITH ANTIGIN BINDING DOMAINS OVER THE CONSTANT REGION OF T-CELL RECEPTOR BETA |
| US11385233B2 (en) | 2015-03-05 | 2022-07-12 | Autolus Limited | Methods of depleting malignant T-cells |
| AU2015228844B2 (en) | 2014-03-11 | 2019-08-15 | Cellectis | Method for generating T-cells compatible for allogenic transplantation |
| JP2017513818A (en) | 2014-03-15 | 2017-06-01 | ノバルティス アーゲー | Treatment of cancer using chimeric antigen receptors |
| CN107172880B (en) | 2014-03-24 | 2021-09-28 | 癌症研究技术有限公司 | Modified antibodies comprising a modified IgG2 domain that elicit agonistic or antagonistic properties and uses thereof |
| UA117289C2 (en) | 2014-04-02 | 2018-07-10 | Ф. Хоффманн-Ля Рош Аг | MULTISPECIFIC ANTIBODY |
| EP2930188A1 (en) | 2014-04-13 | 2015-10-14 | Affimed Therapeutics AG | Trifunctional antigen-binding molecule |
| WO2015164815A1 (en) | 2014-04-24 | 2015-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Superagonists, partial agonists and antagonists of interleukin-2 |
| MX375800B (en) | 2014-04-30 | 2025-03-06 | Max Delbrueck Centrum Fuer Molekulare Medizin Helmholtz Gemeinschaft | HUMANIZED ANTIBODIES AGAINST CD269 (BCMA). |
| AU2015265457B2 (en) | 2014-05-28 | 2021-02-18 | Zymeworks Bc Inc. | Modified antigen binding polypeptide constructs and uses thereof |
| MX375379B (en) | 2014-05-29 | 2025-03-06 | Us Health | Anti-human papillomavirus 16 e7 t cell receptors |
| ES2890079T3 (en) | 2014-05-29 | 2022-01-17 | Macrogenics Inc | Trispecific binding molecules and methods of using same |
| JP6822849B2 (en) | 2014-06-27 | 2021-01-27 | イナート・ファルマ・ソシエテ・アノニムInnate Pharma Pharma S.A. | Multispecific NKp46 binding protein |
| DK3160994T3 (en) | 2014-06-27 | 2025-05-05 | Innate Pharma | MULTISPECIFIC ANTIGEN-BINDING PROTEINS |
| WO2015197582A1 (en) | 2014-06-27 | 2015-12-30 | Innate Pharma | Monomeric multispecific antigen binding proteins |
| JP6744292B2 (en) | 2014-07-29 | 2020-08-19 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Multispecific antibody |
| EP2982692A1 (en) | 2014-08-04 | 2016-02-10 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA |
| KR102067092B1 (en) | 2014-08-04 | 2020-01-17 | 에프. 호프만-라 로슈 아게 | Bispecific t cell activating antigen binding molecules |
| WO2016019969A1 (en) | 2014-08-08 | 2016-02-11 | Ludwig-Maximilians-Universität München | Subcutaneously administered bispecific antibodies for use in the treatment of cancer |
| GB201414823D0 (en) | 2014-08-20 | 2014-10-01 | Argen X Bv | Multispecific antibodies |
| EP3186281B1 (en) | 2014-08-28 | 2019-04-10 | Halozyme, Inc. | Combination therapy with a hyaluronan-degrading enzyme and an immune checkpoint inhibitor |
| CN106687584B (en) | 2014-09-04 | 2021-08-13 | 干细胞技术公司 | Soluble antibody complexes for T cell or NK cell activation and expansion |
| MA40764A (en) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | THERAPEUTIC AGENT INDUCING CYTOTOXICITY |
| US12116633B2 (en) | 2014-10-03 | 2024-10-15 | Oxford University Innovation Limited | Analysis of T-cell monotypia |
| WO2016069283A1 (en) | 2014-10-31 | 2016-05-06 | The Trustees Of The University Of Pennsylvania | Altering gene expression in cart cells and uses thereof |
| AR102522A1 (en) | 2014-11-06 | 2017-03-08 | Hoffmann La Roche | FC REGION VARIATIONS WITH MODIFIED PROPERTIES OF UNION TO FCRN AND PROTEIN A |
| CN107108720A (en) | 2014-11-06 | 2017-08-29 | 豪夫迈·罗氏有限公司 | Fc region variants and its application method that FCRN with change is combined |
| EP3023437A1 (en) | 2014-11-20 | 2016-05-25 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA |
| MX381724B (en) | 2014-11-20 | 2025-03-13 | Hoffmann La Roche | COMMON LIGHT CHAINS AND METHODS OF USE. |
| WO2016087514A1 (en) | 2014-12-02 | 2016-06-09 | Cemm - Forschungszentrum Für Molekulare Medizin Gmbh | Anti-mutant calreticulin antibodies and their use in the diagnosis and therapy of myeloid malignancies |
| JP6721590B2 (en) | 2014-12-03 | 2020-07-15 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Multispecific antibody |
| EP3029068A1 (en) | 2014-12-03 | 2016-06-08 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA for use in the treatment of diseases |
| AU2015357543B2 (en) | 2014-12-05 | 2021-10-21 | Eureka Therapeutics, Inc. | Chimeric antigen receptors targeting Fc Receptor-like 5 and uses thereof |
| BR112017011914A2 (en) | 2014-12-05 | 2018-02-27 | Memorial Sloan-Kettering Cancer Center | Antibody targeting b cell maturation antigen and methods of use? |
| AU2015357053B2 (en) | 2014-12-05 | 2021-10-07 | Merck Patent Gmbh | Domain-exchanged antibody |
| US9767555B2 (en) | 2015-01-05 | 2017-09-19 | Case Western Reserve University | Disease characterization from fused pathology and radiology data |
| PL3242890T3 (en) | 2015-01-08 | 2020-04-30 | BioNTech SE | Agonistic tnf receptor binding agents |
| BR112017015136A2 (en) | 2015-01-14 | 2018-01-30 | Compass Therapeutics Llc | multispecific immunomodulator antigen binding construct polypeptide, multispecific immunomodulator antigen binding construct, conjugate, pharmaceutical composition, method for treating an individual with cancer, method for inhibiting or reducing cancer growth, composition, cell, method of making a polypeptide of multispecific immunomodulatory antigen binding construct, vector or vector set and kit |
| US10689449B2 (en) | 2015-01-20 | 2020-06-23 | Igm Biosciences, Inc. | Multimeric death domain-containing receptor-5 (DR5) antibodies and uses thereof |
| US20170151281A1 (en) | 2015-02-19 | 2017-06-01 | Batu Biologics, Inc. | Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer |
| PT3268390T (en) | 2015-03-13 | 2025-01-13 | Novimmune Sa | Methods of purifying bispecific antibodies |
| TWI703157B (en) | 2015-04-13 | 2020-09-01 | 美商輝瑞股份有限公司 | Cd3-specific antibodies, therapeutic bispecific antibodies and their uses |
| SI3283527T1 (en) | 2015-04-13 | 2021-04-30 | Five Prime Therapeutics, Inc. | Combination therapy against cancer |
| WO2016176756A1 (en) | 2015-05-05 | 2016-11-10 | University Health Network | Nk cells and antibodies for cancer treatment |
| PL3611192T3 (en) | 2015-05-13 | 2025-07-07 | Ablynx N.V. | T cell recruiting polypeptides based on TCR alpha/beta reactivity |
| EA201792662A1 (en) | 2015-06-01 | 2018-04-30 | Медиджин Иммьюнотерапиз Гмбх | SPECIFIC ANTIBODIES TO T-CELL RECEPTOR |
| EA201792661A1 (en) | 2015-06-01 | 2018-05-31 | Медиджин Иммьюнотерапиз Гмбх | METHOD OF OBTAINING ANTIBODIES AGAINST T-CELL RECEPTOR |
| EP3310814B1 (en) | 2015-06-16 | 2023-08-02 | F. Hoffmann-La Roche AG | Humanized and affinity matured antibodies to fcrh5 and methods of use |
| DK3115376T3 (en) | 2015-07-10 | 2018-11-26 | Merus Nv | HUMANT CD3 BINDING ANTIBODY |
| WO2017015623A2 (en) | 2015-07-23 | 2017-01-26 | Inhibrx Lp | Multivalent and multispecific gitr-binding fusion proteins |
| TW202346349A (en) | 2015-07-31 | 2023-12-01 | 德商安美基研究(慕尼黑)公司 | Antibody constructs for dll3 and cd3 |
| MX377710B (en) | 2015-08-03 | 2025-03-11 | Bristol Myers Squibb Co | MONOCLONAL ANTIBODIES AGAINST BCMA. |
| WO2017031104A1 (en) | 2015-08-17 | 2017-02-23 | Janssen Pharmaceutica Nv | Anti-bcma antibodies, bispecific antigen binding molecules that bind bcma and cd3, and uses thereof |
| WO2017037634A1 (en) | 2015-08-31 | 2017-03-09 | National Research Council Of Canada | Tgf-β-receptor ectodomain fusion molecules and uses thereof |
| US11747346B2 (en) | 2015-09-03 | 2023-09-05 | Novartis Ag | Biomarkers predictive of cytokine release syndrome |
| EP3356417A1 (en) | 2015-10-02 | 2018-08-08 | H. Hoffnabb-La Roche Ag | Bispecific t cell activating antigen binding molecules binding mesothelin and cd3 |
| BR112018006811A2 (en) | 2015-10-06 | 2018-10-16 | Univ Minnesota | therapeutic compounds and methods |
| US11161915B2 (en) | 2015-10-08 | 2021-11-02 | Zymeworks Inc. | Antigen-binding polypeptide constructs comprising kappa and lambda light chains and uses thereof |
| US11702477B2 (en) | 2015-11-06 | 2023-07-18 | Orionis Biosciences BV | Bi-functional chimeric proteins and uses thereof |
| EA039859B1 (en) | 2016-02-03 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Bispecific antibody constructs binding egfrviii and cd3 |
| CN109153728A (en)* | 2016-03-21 | 2019-01-04 | 埃尔斯塔治疗公司 | Multispecific and multifunctional molecules and their uses |
| WO2017167350A1 (en) | 2016-03-30 | 2017-10-05 | Horst Lindhofer | Multispecific antibodies for use in the treatment of a neoplasm of the urinary tract |
| WO2017180913A2 (en) | 2016-04-13 | 2017-10-19 | Sanofi | Trispecific and/or trivalent binding proteins |
| CA2937157A1 (en) | 2016-07-25 | 2018-01-25 | Ucl Business Plc | Protein-based t-cell receptor knockdown |
| US11673971B2 (en) | 2016-09-23 | 2023-06-13 | Marengo Therapeutics, Inc. | Multispecific antibody molecules comprising lambda and kappa light chains |
| EP3523331A1 (en) | 2016-10-07 | 2019-08-14 | Novartis AG | Chimeric antigen receptors for the treatment of cancer |
| JP7291396B2 (en) | 2016-11-22 | 2023-06-15 | ティーシーアール2 セラピューティクス インク. | Compositions and methods for TCR reprogramming using fusion proteins |
| WO2018144777A2 (en) | 2017-02-01 | 2018-08-09 | Nant Holdings Ip, Llc | Calreticulin-mediated cancer treatment |
| US20200291089A1 (en) | 2017-02-16 | 2020-09-17 | Elstar Therapeutics, Inc. | Multifunctional molecules comprising a trimeric ligand and uses thereof |
| AU2018256406A1 (en) | 2017-04-19 | 2019-10-17 | Marengo Therapeutics, Inc. | Multispecific molecules and uses thereof |
| WO2018193103A1 (en) | 2017-04-20 | 2018-10-25 | Adc Therapeutics Sa | Combination therapy with an anti-psma antibody-drug conjugate |
| WO2018201047A1 (en) | 2017-04-28 | 2018-11-01 | Elstar Therapeutics, Inc. | Multispecific molecules comprising a non-immunoglobulin heterodimerization domain and uses thereof |
| BR112019024127A2 (en) | 2017-05-24 | 2020-06-23 | Pandion Therapeutics, Inc. | TARGETED IMMUNOTOLERANCE |
| EP3630836A1 (en) | 2017-05-31 | 2020-04-08 | Elstar Therapeutics, Inc. | Multispecific molecules that bind to myeloproliferative leukemia (mpl) protein and uses thereof |
| GB201709203D0 (en) | 2017-06-09 | 2017-07-26 | Autolus Ltd | Antigen-binding domain |
| WO2018237192A1 (en) | 2017-06-21 | 2018-12-27 | Gsbio, Llc | BISPECIFIC ANTIBODIES HETERODIMERS |
| WO2019005641A1 (en) | 2017-06-25 | 2019-01-03 | Systimmune, Inc. | Guidance and navigation control proteins and method of making and using thereof |
| WO2019010224A1 (en) | 2017-07-03 | 2019-01-10 | Torque Therapeutics, Inc. | Fusion molecules targeting immune regulatory cells and uses thereof |
| US20200172868A1 (en) | 2017-07-19 | 2020-06-04 | Rubius Therapeutics, Inc. | Compositions and methods related to multimodal therapeutic cell systems for infectious disease |
| AU2018312251B2 (en) | 2017-07-31 | 2025-02-20 | Trishula Therapeutics, Inc. | Anti-CD39 antibodies, compositions comprising anti-CD39 antibodies and methods of using anti-CD39 antibodies |
| CN111183149A (en) | 2017-08-03 | 2020-05-19 | 辛索克斯公司 | Cytokine conjugates for the treatment of autoimmune diseases |
| WO2019035938A1 (en) | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | Multispecific molecules that bind to bcma and uses thereof |
| US10578740B2 (en) | 2017-08-23 | 2020-03-03 | Mezmeriz Inc. | Coherent optical distance measurement apparatus and method |
| KR20240138135A (en) | 2017-08-25 | 2024-09-20 | 파이브 프라임 테라퓨틱스, 인크. | B7-h4 antibodies and methods of use thereof |
| EA202090718A1 (en) | 2017-09-14 | 2020-07-01 | Драгонфлай Терапьютикс, Инк. | PROTEINS BINDING NKG2D, CD16 AND LECTIN-LIKE C-TYPE MOLECULE-1 (CLL-1) |
| CN111629734A (en) | 2017-09-27 | 2020-09-04 | 南加利福尼亚大学 | Novel platforms for costimulation, novel CAR designs, and other enhancements for adoptive cell therapy |
| GB201718088D0 (en) | 2017-11-01 | 2017-12-13 | Autolus Ltd | Vectors |
| MX2020005041A (en) | 2017-11-21 | 2020-10-12 | Univ Leland Stanford Junior | Partial agonists of interleukin-2. |
| EP3713959A1 (en) | 2017-11-21 | 2020-09-30 | Innate Pharma | Multispecific antigen binding proteins |
| US20200377571A1 (en) | 2017-12-08 | 2020-12-03 | Elstar Therapeutics, Inc. | Multispecific molecules and uses thereof |
| RU2694412C9 (en) | 2017-12-25 | 2019-09-18 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Российский национальный исследовательский медицинский университет им. Н.И. Пирогова" Министерства здравоохранения Российской Федерации (ФГБОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России) | Monoclonal antibodies and methods of using them |
| EP3733716A4 (en) | 2017-12-26 | 2021-11-24 | Nanjing GenScript Biotech Co., Ltd. | Fusion protein dimer using antibody fc region as backbone and use thereof |
| TWI817974B (en) | 2017-12-28 | 2023-10-11 | 日商中外製藥股份有限公司 | Cytotoxicity-inducing therapeutic agent |
| GB201800298D0 (en) | 2018-01-09 | 2018-02-21 | Autolus Ltd | Method |
| WO2019139987A1 (en) | 2018-01-09 | 2019-07-18 | Elstar Therapeutics, Inc. | Calreticulin binding constructs and engineered t cells for the treatment of diseases |
| EP3752178A1 (en) | 2018-02-16 | 2020-12-23 | Iltoo Pharma | Use of interleukin 2 for treating sjögren's syndrome |
| WO2019178364A2 (en) | 2018-03-14 | 2019-09-19 | Elstar Therapeutics, Inc. | Multifunctional molecules and uses thereof |
| EP3765517A1 (en) | 2018-03-14 | 2021-01-20 | Elstar Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| KR20210005872A (en) | 2018-03-28 | 2021-01-15 | 오리오니스 바이오사이언시즈 인코포레이티드 | Bifunctional proteins and constructs thereof |
| TW202003580A (en) | 2018-05-21 | 2020-01-16 | 美商坎伯斯治療有限責任公司 | Compositions and methods for enhancing the killing of target cells by NK cells |
| EA202091977A1 (en) | 2018-05-28 | 2021-02-09 | Драгонфлай Терапьютикс, Инк. | MULTI-SPECIFIC BINDING PROTEINS THAT BIND CD33, NKG2D AND CD16 AND METHODS OF APPLICATION |
| EP3810640A1 (en) | 2018-06-25 | 2021-04-28 | University of Washington | De novo design of potent and selective interleukin mimetics |
| WO2020010250A2 (en) | 2018-07-03 | 2020-01-09 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| US20210277120A1 (en) | 2018-07-18 | 2021-09-09 | The General Hospital Corporation | Compositions and methods for treatment of t cell malignancies |
| CN108949698B (en) | 2018-07-31 | 2019-05-31 | 广东和信健康科技有限公司 | Hybridoma cell strain C11-6F7 and its HCMV monoclonal antibody and application of generation |
| GB201812650D0 (en) | 2018-08-03 | 2018-09-19 | Autolus Ltd | Molecular assessment of TRBC usage |
| UY38326A (en) | 2018-08-03 | 2020-01-31 | Amgen Inc | ANTIBODY CONSTRUCTS FOR CLDN18.2 AND CD3 |
| EA202091888A1 (en) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | VARIABLE ANTIBODY DOMAINS TARGETED ON THE NKG2D RECEPTOR |
| JP7512210B2 (en) | 2018-09-21 | 2024-07-08 | イノベント バイオロジックス (スウツォウ) カンパニー,リミテッド | Novel interleukin 2 and uses thereof |
| CA3114038A1 (en) | 2018-09-25 | 2020-04-02 | Harpoon Therapeutics, Inc. | Dll3 binding proteins and methods of use |
| CA3114179A1 (en) | 2018-09-28 | 2020-04-02 | Pierre Fabre Medicament | New immunocytokines for the treatment of cancer |
| KR20210110563A (en) | 2018-10-18 | 2021-09-08 | 킨드레드 바이오사이언시스, 인코포레이티드 | FC variants with altered binding to the neonatal FC receptor (FCRN) for veterinary use |
| GB201817172D0 (en) | 2018-10-22 | 2018-12-05 | Autolus Ltd | Antibody |
| KR20210080460A (en) | 2018-10-23 | 2021-06-30 | 드래곤플라이 쎄라퓨틱스, 인크. | Heterodimeric Fc-fused protein |
| BR112021008204A2 (en) | 2018-10-29 | 2021-08-10 | 1Globe Biomedical Co., Ltd. | new rationally designed protein compositions |
| GB201817822D0 (en) | 2018-10-31 | 2018-12-19 | Autolus Ltd | Binding domain |
| CN112912388A (en) | 2018-11-20 | 2021-06-04 | 华盛顿大学 | Split interleukin mimetics and their uses |
| RU2712251C1 (en) | 2018-12-25 | 2020-01-27 | Федеральное государственное автономное образовательное учреждение высшего образования "Российский национальный исследовательский медицинский университет имени Н.И. Пирогова" Министерства здравоохранения Российской Федерации (ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России) | Humanised anti-beta 9 chain antibodies of human trbv9 tkp family, and methods of using |
| AR117735A1 (en) | 2018-12-25 | 2021-08-25 | Joint Stock Company Biocad | MONOCLONAL ANTIBODIES THAT SPECIFICALLY BIND TO REGION b OF THE HUMAN T-CELL RECEPTOR FAMILY TRBV-9, AND METHODS FOR ITS USE |
| WO2020142672A2 (en) | 2019-01-04 | 2020-07-09 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| US11235032B2 (en) | 2019-01-23 | 2022-02-01 | Massachusetts Institute Of Technology | Combination immunotherapy dosing regimen for immune checkpoint blockade |
| SG11202109061YA (en) | 2019-02-21 | 2021-09-29 | Marengo Therapeutics Inc | Multifunctional molecules that bind to t cell related cancer cells and uses thereof |
| SG11202109056TA (en) | 2019-02-21 | 2021-09-29 | Marengo Therapeutics Inc | Multifunctional molecules that bind to calreticulin and uses thereof |
| WO2020172596A1 (en) | 2019-02-21 | 2020-08-27 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and thereof |
| AU2020224680B2 (en) | 2019-02-21 | 2025-06-19 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to T cells and uses thereof to treat autoimmune disorders |
| SG11202108955QA (en) | 2019-02-21 | 2021-09-29 | Marengo Therapeutics Inc | Antibody molecules that bind to nkp30 and uses thereof |
| US11673953B2 (en) | 2019-03-01 | 2023-06-13 | Allogene Therapeutics, Inc. | DLL3 targeting chimeric antigen receptors and binding agents |
| EP3937977A2 (en) | 2019-03-11 | 2022-01-19 | Janssen Biotech, Inc. | Anti-v beta17 /anti-cd123 bispecific antibodies |
| WO2020249757A1 (en) | 2019-06-14 | 2020-12-17 | Philogen S.P.A | Immunoconjugates comprising a single chain diabody and interleukin-15 or interleukin-15 and a sushi domain of interleukin-15 receptor alpha |
| KR20220097443A (en) | 2019-11-05 | 2022-07-07 | 메르크 파텐트 게엠베하 | Combination inhibition of PD-1, TGFβ and TIGIT for the treatment of cancer |
| AU2020384369B2 (en) | 2019-11-14 | 2025-02-13 | Marengo Therapeutics, Inc. | Anti-TCR antibody molecules and uses thereof |
| CN116234829A (en) | 2020-01-03 | 2023-06-06 | 马伦戈治疗公司 | anti-TCR antibody molecules and uses thereof |
| EP4084821A4 (en) | 2020-01-03 | 2024-04-24 | Marengo Therapeutics, Inc. | CD33-BINDING MULTIFUNCTIONAL MOLECULES AND THEIR USES |
| JP2023510806A (en) | 2020-01-09 | 2023-03-15 | ビオミュネクス・ファーマシューティカルズ | Multispecific antibodies that bind to both MAIT and tumor cells |
| EP4121518A4 (en) | 2020-03-16 | 2024-06-19 | Marengo Therapeutics, Inc. | MANIPULATED CELL COMPOSITIONS AND METHODS OF USE THEREOF |
| AU2021261420A1 (en) | 2020-04-24 | 2022-12-01 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to T cell related cancer cells and uses thereof |
| CN116917316A (en) | 2020-08-26 | 2023-10-20 | 马伦戈治疗公司 | Antibody molecules that bind to NKp30 and uses thereof |
| CN116249718A (en) | 2020-08-26 | 2023-06-09 | 马伦戈治疗公司 | Multifunctional molecules binding to calreticulin and uses thereof |
| KR20230074487A (en) | 2020-08-26 | 2023-05-30 | 마렝고 테라퓨틱스, 인크. | How to detect TRBC1 or TRBC2 |
| EP4294527A1 (en) | 2021-02-17 | 2023-12-27 | GammaDelta Therapeutics Limited | Anti-tcr delta variable 1 antibodies |
| US20240150460A1 (en)* | 2021-02-26 | 2024-05-09 | Shenghe (China) Biopharmaceutical Co., Ltd. | Anti-nkp30 antibody and application thereof |
| GB2623199A (en) | 2021-04-08 | 2024-04-10 | Marengo Therapeutics Inc | Multifunctional molecules binding to TCR and uses thereof |
| EP4337252A4 (en) | 2021-05-10 | 2025-04-23 | Amgen Inc. | Dosing regimen for combination therapy targeting dll3 and pd-1 |
| EP4426321A2 (en) | 2021-11-05 | 2024-09-11 | Marengo Therapeutics, Inc. | Immune cell populations and uses thereof |
| CA3242160A1 (en) | 2021-12-22 | 2023-06-29 | Marengo Therapeutics, Inc. | Multifuntional molecules binding to tcr and uses thereof |
| EP4466019A2 (en) | 2022-01-21 | 2024-11-27 | Marengo Therapeutics, Inc. | Multifunctional molecules comprising g6b binder and/or cd34 binder and uses thereof |
| EP4601747A1 (en) | 2022-10-12 | 2025-08-20 | Marengo Therapeutics, Inc. | Multifunctional molecules binding to tcr and uses thereof |
| AU2023361491A1 (en) | 2022-10-12 | 2025-05-08 | Marengo Therapeutics, Inc. | Multifunctional molecules binding to tcr and uses thereof |
| WO2024197082A2 (en) | 2023-03-21 | 2024-09-26 | Marengo Therapeutics, Inc. | Tcr targeting molecules and uses thereof |
| WO2024226532A2 (en) | 2023-04-24 | 2024-10-31 | Marengo Therapeutics, Inc. | Multifunctional molecules binding to tcr and uses thereof |
| WO2024227109A1 (en) | 2023-04-27 | 2024-10-31 | Marengo Therapeutics, Inc. | Combination therapies using molecules binding to tcr |
| WO2024254611A2 (en) | 2023-06-09 | 2024-12-12 | Marengo Therapeutics, Inc. | Multispecific molecules binding to tcr and uses thereof |