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SG11202108955QA - Antibody molecules that bind to nkp30 and uses thereof - Google Patents

Antibody molecules that bind to nkp30 and uses thereof

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Publication number
SG11202108955QA
SG11202108955QASG11202108955QASG11202108955QASG11202108955QASG 11202108955Q ASG11202108955Q ASG 11202108955QASG 11202108955Q ASG11202108955Q ASG 11202108955QASG 11202108955Q ASG11202108955Q ASG 11202108955QASG 11202108955Q ASG11202108955Q ASG 11202108955QA
Authority
SG
Singapore
Prior art keywords
nkp30
bind
antibody molecules
antibody
molecules
Prior art date
Application number
SG11202108955QA
Inventor
Andreas Loew
Nidhi Malhotra
Madan Katragadda
Brian Vash
Stephanie Maiocco
Original Assignee
Marengo Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Marengo Therapeutics IncfiledCriticalMarengo Therapeutics Inc
Publication of SG11202108955QApublicationCriticalpatent/SG11202108955QA/en

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SG11202108955QA2019-02-212020-02-21Antibody molecules that bind to nkp30 and uses thereofSG11202108955QA (en)

Applications Claiming Priority (2)

Application NumberPriority DateFiling DateTitle
US201962808582P2019-02-212019-02-21
PCT/US2020/019329WO2020172605A1 (en)2019-02-212020-02-21Antibody molecules that bind to nkp30 and uses thereof

Publications (1)

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SG11202108955QAtrue SG11202108955QA (en)2021-09-29

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SG11202108955QASG11202108955QA (en)2019-02-212020-02-21Antibody molecules that bind to nkp30 and uses thereof

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US (1)US12384842B2 (en)
EP (1)EP3927747A1 (en)
JP (2)JP7579795B2 (en)
CN (2)CN114127111B (en)
AU (1)AU2020224681A1 (en)
CA (1)CA3130508A1 (en)
GB (1)GB2597851B (en)
SG (1)SG11202108955QA (en)
WO (1)WO2020172605A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
WO2019139987A1 (en)2018-01-092019-07-18Elstar Therapeutics, Inc.Calreticulin binding constructs and engineered t cells for the treatment of diseases
WO2020010250A2 (en)2018-07-032020-01-09Elstar Therapeutics, Inc.Anti-tcr antibody molecules and uses thereof
SG11202108955QA (en)2019-02-212021-09-29Marengo Therapeutics IncAntibody molecules that bind to nkp30 and uses thereof
SG11202109061YA (en)2019-02-212021-09-29Marengo Therapeutics IncMultifunctional molecules that bind to t cell related cancer cells and uses thereof
CN116368154A (en)2020-10-082023-06-30阿菲姆德股份有限公司 trispecific binder
CN114957469B (en)*2021-02-262024-02-20盛禾(中国)生物制药有限公司anti-NKp 30 antibody and application thereof
US20240150460A1 (en)*2021-02-262024-05-09Shenghe (China) Biopharmaceutical Co., Ltd.Anti-nkp30 antibody and application thereof
CN115124620B (en)*2021-03-292023-12-12盛禾(中国)生物制药有限公司Antibody capable of activating NK cells and application thereof
WO2022261337A2 (en)*2021-06-112022-12-15The Regents Of The University Of CaliforniaAntibodies that stimulate nk cell-mediated cytotoxicity
EP4359437A2 (en)*2021-06-222024-05-01Merck Patent GmbHVhh-based nkp30 binders
IL308154A (en)2021-07-302023-12-01Affimed GmbhDuplexbodies
EP4587123A1 (en)2022-09-152025-07-23Avidicure IP B.V.Multispecific antigen binding proteins for tumor-targeting of nk cells and use thereof
WO2025191136A1 (en)2024-03-152025-09-18Avidicure Ip B.V.Muteins of 4-1bb ligand extracellular domain, fusion proteins comprising the same and uses thereof
WO2025191133A1 (en)2024-03-152025-09-18Avidicure Ip B.V.Il-21 muteins, fusion proteins comprising the same and uses thereof

Family Cites Families (660)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US861745A (en)1906-11-211907-07-30Jefferson D MaxwellHydraulic dredging apparatus.
US4475196A (en)1981-03-061984-10-02Zor Clair GInstrument for locating faults in aircraft passenger reading light and attendant call control system
US4447233A (en)1981-04-101984-05-08Parker-Hannifin CorporationMedication infusion pump
US4433059A (en)1981-09-081984-02-21Ortho Diagnostic Systems Inc.Double antibody conjugate
US4444878A (en)1981-12-211984-04-24Boston Biomedical Research Institute, Inc.Bispecific antibody determinants
US4439196A (en)1982-03-181984-03-27Merck & Co., Inc.Osmotic drug delivery system
US4522811A (en)1982-07-081985-06-11Syntex (U.S.A.) Inc.Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4447224A (en)1982-09-201984-05-08Infusaid CorporationVariable flow implantable infusion apparatus
US4487603A (en)1982-11-261984-12-11Cordis CorporationImplantable microinfusion pump system
US4816567A (en)1983-04-081989-03-28Genentech, Inc.Recombinant immunoglobin preparations
US4486194A (en)1983-06-081984-12-04James FerraraTherapeutic device for administering medicaments through the skin
WO1985000817A1 (en)1983-08-101985-02-28AmgenMicrobial expression of interleukin ii
JPS6147500A (en)1984-08-151986-03-07Res Dev Corp Of Japan Chimeric monoclonal antibody and its production method
EP0173494A3 (en)1984-08-271987-11-25The Board Of Trustees Of The Leland Stanford Junior UniversityChimeric receptors by dna splicing and expression
GB8422238D0 (en)1984-09-031984-10-10Neuberger M SChimeric proteins
JPS61134325A (en)1984-12-041986-06-21Teijin LtdExpression of hybrid antibody gene
US4596556A (en)1985-03-251986-06-24Bioject, Inc.Hypodermic injection apparatus
US4737456A (en)1985-05-091988-04-12Syntex (U.S.A.) Inc.Reducing interference in ligand-receptor binding assays
US5374548A (en)1986-05-021994-12-20Genentech, Inc.Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
MX9203291A (en)1985-06-261992-08-01Liposome Co Inc LIPOSOMAS COUPLING METHOD.
US4676980A (en)1985-09-231987-06-30The United States Of America As Represented By The Secretary Of The Department Of Health And Human ServicesTarget specific cross-linked heteroantibodies
EP0247091B1 (en)1985-11-011993-09-29Xoma CorporationModular assembly of antibody genes, antibodies prepared thereby and use
US5225539A (en)1986-03-271993-07-06Medical Research CouncilRecombinant altered antibodies and methods of making altered antibodies
GB8607679D0 (en)1986-03-271986-04-30Winter G PRecombinant dna product
US6548640B1 (en)1986-03-272003-04-15Btg International LimitedAltered antibodies
US5869620A (en)1986-09-021999-02-09Enzon, Inc.Multivalent antigen-binding proteins
IL85035A0 (en)1987-01-081988-06-30Int Genetic EngPolynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
EP0307434B2 (en)1987-03-181998-07-29Scotgen Biopharmaceuticals, Inc.Altered antibodies
US4941880A (en)1987-06-191990-07-17Bioject, Inc.Pre-filled ampule and non-invasive hypodermic injection device assembly
US4790824A (en)1987-06-191988-12-13Bioject, Inc.Non-invasive hypodermic injection device
US5770701A (en)1987-10-301998-06-23American Cyanamid CompanyProcess for preparing targeted forms of methyltrithio antitumor agents
US5606040A (en)1987-10-301997-02-25American Cyanamid CompanyAntitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group
US5057423A (en)1987-12-181991-10-15University Of PittsburghMethod for the preparation of pure LAK-active lymphocytes
US5731116A (en)1989-05-171998-03-24Dai Nippon Printing Co., Ltd.Electrostatic information recording medium and electrostatic information recording and reproducing method
JPH021556A (en)1988-06-091990-01-05Snow Brand Milk Prod Co LtdHybrid antibody and production thereof
EP1541682A3 (en)1988-09-022005-07-06Dyax Corp.Generation and selection of recombinant varied binding proteins
US5223409A (en)1988-09-021993-06-29Protein Engineering Corp.Directed evolution of novel binding proteins
FI903489A7 (en)1988-11-111990-07-10Medical Res Council Ligands containing one moiety, receptors containing these ligands, methods for their preparation and uses of the ligands and receptors
US6352694B1 (en)1994-06-032002-03-05Genetics Institute, Inc.Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
US6534055B1 (en)1988-11-232003-03-18Genetics Institute, Inc.Methods for selectively stimulating proliferation of T cells
US6905680B2 (en)1988-11-232005-06-14Genetics Institute, Inc.Methods of treating HIV infected subjects
US5766947A (en)1988-12-141998-06-16Astra AbMonoclonal antibodies reactive with an epitope of a Vβ3.1 variable region of a T cell receptor
US5223426A (en)1988-12-151993-06-29T Cell Sciences, Inc.Monoclonal antibodies reactive with defined regions of the t-cell antigen receptor
US5530101A (en)1988-12-281996-06-25Protein Design Labs, Inc.Humanized immunoglobulins
US5116615A (en)1989-01-271992-05-26Immunolytics, Inc.Method for treating benign prostatic hypertrophy
GB8905669D0 (en)1989-03-131989-04-26Celltech LtdModified antibodies
US5108921A (en)1989-04-031992-04-28Purdue Research FoundationMethod for enhanced transmembrane transport of exogenous molecules
US6291158B1 (en)1989-05-162001-09-18Scripps Research InstituteMethod for tapping the immunological repertoire
CA2018248A1 (en)1989-06-071990-12-07Clyde W. ShearmanMonoclonal antibodies against the human alpha/beta t-cell receptor, their production and use
DE3920358A1 (en)1989-06-221991-01-17Behringwerke Ag BISPECIFIC AND OLIGO-SPECIFIC, MONO- AND OLIGOVALENT ANTI-BODY CONSTRUCTS, THEIR PRODUCTION AND USE
WO1991000906A1 (en)1989-07-121991-01-24Genetics Institute, Inc.Chimeric and transgenic animals capable of producing human antibodies
AU6290090A (en)1989-08-291991-04-08University Of SouthamptonBi-or trispecific (fab)3 or (fab)4 conjugates
CA2026147C (en)1989-10-252006-02-07Ravi J. ChariCytotoxic agents comprising maytansinoids and their therapeutic use
US5208020A (en)1989-10-251993-05-04Immunogen Inc.Cytotoxic agents comprising maytansinoids and their therapeutic use
US5959177A (en)1989-10-271999-09-28The Scripps Research InstituteTransgenic plants expressing assembled secretory antibodies
US5064413A (en)1989-11-091991-11-12Bioject, Inc.Needleless hypodermic injection device
US5312335A (en)1989-11-091994-05-17Bioject Inc.Needleless hypodermic injection device
US6150584A (en)1990-01-122000-11-21Abgenix, Inc.Human antibodies derived from immunized xenomice
DK0463151T3 (en)1990-01-121996-07-01Cell Genesys Inc Generation of xenogenic antibodies
US6075181A (en)1990-01-122000-06-13Abgenix, Inc.Human antibodies derived from immunized xenomice
US5273743A (en)1990-03-091993-12-28Hybritech IncorporatedTrifunctional antibody-like compounds as a combined diagnostic and therapeutic agent
US5427908A (en)1990-05-011995-06-27Affymax Technologies N.V.Recombinant library screening methods
GB9012995D0 (en)1990-06-111990-08-01Celltech LtdMultivalent antigen-binding proteins
GB9015198D0 (en)1990-07-101990-08-29Brien Caroline J OBinding substance
US6172197B1 (en)1991-07-102001-01-09Medical Research CouncilMethods for producing members of specific binding pairs
WO1992020791A1 (en)1990-07-101992-11-26Cambridge Antibody Technology LimitedMethods for producing members of specific binding pairs
ATE352612T1 (en)1990-08-292007-02-15Pharming Intellectual Pty Bv HOMOLOGOUS RECOMBINATION IN MAMMAL CELLS
US5770429A (en)1990-08-291998-06-23Genpharm International, Inc.Transgenic non-human animals capable of producing heterologous antibodies
KR100272077B1 (en)1990-08-292000-11-15젠팜인터내셔날,인코포레이티드Transgenic non-human animals capable of producing heterologous antibodies
GB9022788D0 (en)1990-10-191990-12-05Cortecs LtdPharmaceutical formulations
ES2113940T3 (en)1990-12-031998-05-16Genentech Inc ENRICHMENT METHOD FOR PROTEIN VARIANTS WITH ALTERED UNION PROPERTIES.
US5582996A (en)1990-12-041996-12-10The Wistar Institute Of Anatomy & BiologyBifunctional antibodies and method of preparing same
US5571894A (en)1991-02-051996-11-05Ciba-Geigy CorporationRecombinant antibodies specific for a growth factor receptor
EP0575485A1 (en)1991-03-011993-12-29Dyax Corp.Process for the development of binding mini-proteins
DE69233750D1 (en)1991-04-102009-01-02Scripps Research Inst Libraries of heterodimeric receptors using phagemids
DE69233482T2 (en)1991-05-172006-01-12Merck & Co., Inc. Method for reducing the immunogenicity of antibody variable domains
DE4118120A1 (en)1991-06-031992-12-10Behringwerke Ag TETRAVALENT BISPECIFIC RECEPTORS, THEIR PRODUCTION AND USE
US6511663B1 (en)1991-06-112003-01-28Celltech R&D LimitedTri- and tetra-valent monospecific antigen-binding proteins
US6407213B1 (en)1991-06-142002-06-18Genentech, Inc.Method for making humanized antibodies
US5637481A (en)1993-02-011997-06-10Bristol-Myers Squibb CompanyExpression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell
DE4122599C2 (en)1991-07-081993-11-11Deutsches Krebsforsch Phagemid for screening antibodies
GB9114948D0 (en)1991-07-111991-08-28Pfizer LtdProcess for preparing sertraline intermediates
US5747036A (en)1991-08-281998-05-05Brigham & Women's HospitalMethods and compositions for detecting and treating a subset of human patients having an autoimmune disease
EP0604580A1 (en)1991-09-191994-07-06Genentech, Inc.EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab') 2? ANTIBODIES
FI941572L (en)1991-10-071994-05-27Oncologix Inc Combination and method of use of anti-erbB-2 monoclonal antibodies
WO1993008829A1 (en)1991-11-041993-05-13The Regents Of The University Of CaliforniaCompositions that mediate killing of hiv-infected cells
ATE207080T1 (en)1991-11-252001-11-15Enzon Inc MULTIVALENT ANTIGEN-BINDING PROTEINS
US5932448A (en)1991-11-291999-08-03Protein Design Labs., Inc.Bispecific antibody heterodimers
ES2227512T3 (en)1991-12-022005-04-01Medical Research Council PRODUCTION OF ANTIBODIES AGAINST SELF-ANTIGENS FROM REPERTORIES OF ANTIBODY SEGMENTS FIXED IN A PHOTO.
CA2124460C (en)1991-12-022007-08-28Andrew David GriffithsProduction of anti-self antibodies from segment repertoires and displayed on phage
GB9125768D0 (en)1991-12-041992-02-05Hale GeoffreyTherapeutic method
JP3490437B2 (en)1992-01-232004-01-26メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング Monomeric and dimeric antibody fragment fusion proteins
EP0625200B1 (en)1992-02-062005-05-11Chiron CorporationBiosynthetic binding protein for cancer marker
WO1993023537A1 (en)1992-05-081993-11-25Creative BiomoleculesChimeric multivalent protein analogues and methods of use thereof
US5383851A (en)1992-07-241995-01-24Bioject Inc.Needleless hypodermic injection device
ATE452975T1 (en)1992-08-212010-01-15Univ Bruxelles IMMUNOGLOBULINS WITHOUT LIGHT CHAINS
US6005079A (en)1992-08-211999-12-21Vrije Universiteit BrusselsImmunoglobulins devoid of light chains
US6765087B1 (en)1992-08-212004-07-20Vrije Universiteit BrusselImmunoglobulins devoid of light chains
WO1994007921A1 (en)1992-09-251994-04-14Commonwealth Scientific And Industrial Research OrganisationTarget binding polypeptide
EP0669987B1 (en)1992-09-252008-08-13Aventis Pharma S.A.Adenovirus vectors for the transfer of foreign genes into cells of the central nervous system, particularly in brain
GB9221657D0 (en)1992-10-151992-11-25Scotgen LtdRecombinant bispecific antibodies
CA2126967A1 (en)1992-11-041994-05-11Anna M. WuNovel antibody construct
EP0752248B1 (en)1992-11-132000-09-27Idec Pharmaceuticals CorporationTherapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
GB9323648D0 (en)1992-11-231994-01-05Zeneca LtdProteins
US5635483A (en)1992-12-031997-06-03Arizona Board Of Regents Acting On Behalf Of Arizona State UniversityTumor inhibiting tetrapeptide bearing modified phenethyl amides
AU690528B2 (en)1992-12-041998-04-30Medical Research CouncilMultivalent and multispecific binding proteins, their manufacture and use
US5780588A (en)1993-01-261998-07-14Arizona Board Of RegentsElucidation and synthesis of selected pentapeptides
WO1994025591A1 (en)1993-04-291994-11-10Unilever N.V.PRODUCTION OF ANTIBODIES OR (FUNCTIONALIZED) FRAGMENTS THEREOF DERIVED FROM HEAVY CHAIN IMMUNOGLOBULINS OF $i(CAMELIDAE)
JPH0787994A (en)1993-04-301995-04-04Sumitomo Electric Ind Ltd Monoclonal antibody against T cell antigen receptor Vβ22 and method for producing the same
JPH08511420A (en)1993-06-161996-12-03セルテック・セラピューテイクス・リミテッド Body
US6476198B1 (en)1993-07-132002-11-05The Scripps Research InstituteMultispecific and multivalent antigen-binding polypeptide molecules
CA2147626C (en)1993-08-101998-04-21Mark D. ButlerCell encapsulating device
US5635602A (en)1993-08-131997-06-03The Regents Of The University Of CaliforniaDesign and synthesis of bispecific DNA-antibody conjugates
WO1995009917A1 (en)1993-10-071995-04-13The Regents Of The University Of CaliforniaGenetically engineered bispecific tetravalent antibodies
GB9325182D0 (en)1993-12-081994-02-09T Cell Sciences IncHumanized antibodies or binding proteins thereof specific for t cell subpopulations exhibiting select beta chain variable regions
SE9400088D0 (en)1994-01-141994-01-14Kabi Pharmacia Ab Bacterial receptor structures
US5773001A (en)1994-06-031998-06-30American Cyanamid CompanyConjugates of methyltrithio antitumor agents and intermediates for their synthesis
US5968753A (en)1994-06-141999-10-19Nexell Therapeutics, Inc.Positive and positive/negative cell selection mediated by peptide release
EP0787185A2 (en)1994-10-201997-08-06MorphoSys AGTargeted hetero-association of recombinant proteins to multi-functional complexes
US5789199A (en)1994-11-031998-08-04Genentech, Inc.Process for bacterial production of polypeptides
FR2727867B1 (en)1994-12-131997-01-31Rhone Poulenc Rorer Sa GENE TRANSFER IN MEDULLAR MOTONURONES USING ADENOVIRAL VECTORS
AU712441B2 (en)1994-12-141999-11-04Scripps Research Institute, TheIn vivo activation of tumor-specific cytotoxic T cells
US5840523A (en)1995-03-011998-11-24Genetech, Inc.Methods and compositions for secretion of heterologous polypeptides
US5731168A (en)1995-03-011998-03-24Genentech, Inc.Method for making heteromultimeric polypeptides
US5641870A (en)1995-04-201997-06-24Genentech, Inc.Low pH hydrophobic interaction chromatography for antibody purification
US5869046A (en)1995-04-141999-02-09Genentech, Inc.Altered polypeptides with increased half-life
EP0827544B1 (en)1995-05-232004-08-18MorphoSys AGMultimeric proteins
US5626561A (en)1995-06-071997-05-06Gore Hybrid Technologies, Inc.Implantable containment apparatus for a therapeutical device and method for loading and reloading the device therein
US5714586A (en)1995-06-071998-02-03American Cyanamid CompanyMethods for the preparation of monomeric calicheamicin derivative/carrier conjugates
EP0773753B1 (en)1995-06-072003-10-08Gore Hybrid Technologies, Inc.An implantable containment apparatus for a therapeutical device
US5712374A (en)1995-06-071998-01-27American Cyanamid CompanyMethod for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
US5811097A (en)1995-07-251998-09-22The Regents Of The University Of CaliforniaBlockade of T lymphocyte down-regulation associated with CTLA-4 signaling
US6267958B1 (en)1995-07-272001-07-31Genentech, Inc.Protein formulation
AU6854696A (en)1995-09-221997-04-09Gore Hybrid Technologies, Inc.Improved cell encapsulation device
WO1997014719A1 (en)1995-10-161997-04-24Unilever N.V.A bifunctional or bivalent antibody fragment analogue
GB9603256D0 (en)1996-02-161996-04-17Wellcome FoundAntibodies
US5849589A (en)1996-03-111998-12-15Duke UniversityCulturing monocytes with IL-4, TNF-α and GM-CSF TO induce differentiation to dendric cells
EP0894135B1 (en)1996-04-042004-08-11Unilever PlcMultivalent and multispecific antigen-binding protein
EP0871480A4 (en)1996-10-042001-04-04Univ Jefferson T-LYMPHOCYTES TRIGGERING AN IMMUNE REACTION AND METHODS OF USE
JP2002505574A (en)1997-04-302002-02-19エンゾン,インコーポレイテッド Polyalkylene oxide-modified single-chain polypeptides
US20030207346A1 (en)1997-05-022003-11-06William R. ArathoonMethod for making multispecific antibodies having heteromultimeric and common components
US20020062010A1 (en)1997-05-022002-05-23Genentech, Inc.Method for making multispecific antibodies having heteromultimeric and common components
CA2304254C (en)1997-06-112012-05-22Hans Christian ThogersenTrimerising module
DK0985039T3 (en)1997-06-122008-06-09Novartis Int Pharm Ltd Artificial antibody polypeptides
US6171586B1 (en)1997-06-132001-01-09Genentech, Inc.Antibody formulation
WO1998058964A1 (en)1997-06-241998-12-30Genentech, Inc.Methods and compositions for galactosylated glycoproteins
WO1999004820A2 (en)1997-07-211999-02-04Pharmacia & Upjohn AbCytolysis of target cells by superantigen conjugates inducing t-cell activation
US6040498A (en)1998-08-112000-03-21North Caroline State UniversityGenetically engineered duckweed
DE19742706B4 (en)1997-09-262013-07-25Pieris Proteolab Ag lipocalin muteins
GB9722131D0 (en)1997-10-201997-12-17Medical Res CouncilMethod
BR9813276A (en)1997-10-272000-08-22Unilever Nv Multivalent antigen binding protein, nucleotide sequences, expression vector, host cell, process for preparing multivalent antigen binding protein, and use thereof
DE69840412D1 (en)1997-10-312009-02-12Genentech Inc METHODS AND COMPOSITIONS CONTAINING GLYCOPROTEIN GLYCOR FORMS
US6610833B1 (en)1997-11-242003-08-26The Institute For Human Genetics And BiochemistryMonoclonal human natural antibodies
DK1034298T3 (en)1997-12-052012-01-30Scripps Research Inst Humanization of murine antibody
ATE283364T1 (en)1998-01-232004-12-15Vlaams Interuniv Inst Biotech MULTIPURPOSE ANTIBODIES DERIVATIVES
AUPP221098A0 (en)1998-03-061998-04-02Diatech Pty LtdV-like domain binding molecules
ES2292236T3 (en)1998-04-022008-03-01Genentech, Inc. VARIATIONS OF ANTIBODIES AND THEIR FRAGMENTS.
US6194551B1 (en)1998-04-022001-02-27Genentech, Inc.Polypeptide variants
HUP9900956A2 (en)1998-04-092002-04-29Aventis Pharma Deutschland Gmbh.Single-chain multiple antigen-binding molecules, their preparation and use
WO1999054342A1 (en)1998-04-201999-10-28Pablo UmanaGlycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity
DE19819846B4 (en)1998-05-052016-11-24Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Multivalent antibody constructs
GB9812545D0 (en)1998-06-101998-08-05Celltech Therapeutics LtdBiological products
EP1100830B1 (en)1998-07-282003-10-01Micromet AGHeterominibodies
US6333396B1 (en)1998-10-202001-12-25Enzon, Inc.Method for targeted delivery of nucleic acids
US6818418B1 (en)1998-12-102004-11-16Compound Therapeutics, Inc.Protein scaffolds for antibody mimics and other binding proteins
PT1137941E (en)1998-12-102009-10-15Brystol Myers Squibb CompanyProtein scaffolds for antibody mimics and other binding proteins
US6737056B1 (en)1999-01-152004-05-18Genentech, Inc.Polypeptide variants with altered effector function
HUP0104865A3 (en)1999-01-152004-07-28Genentech IncPolypeptide variants with altered effector function
US20030095967A1 (en)1999-01-252003-05-22Mackay FabienneBAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders
EP1163339A1 (en)1999-04-012001-12-19Innogenetics N.V.A polypeptide structure for use as a scaffold
EP3031917A1 (en)1999-04-092016-06-15Kyowa Hakko Kirin Co., Ltd.Method for controlling the activity of immunologically functional molecule
US7534866B2 (en)2005-10-192009-05-19Ibc Pharmaceuticals, Inc.Methods and compositions for generating bioactive assemblies of increased complexity and uses
US7527787B2 (en)2005-10-192009-05-05Ibc Pharmaceuticals, Inc.Multivalent immunoglobulin-based bioactive assemblies
DE19932688B4 (en)1999-07-132009-10-08Scil Proteins Gmbh Design of beta-sheet proteins of gamma-II-crystalline antibody-like
BR0013391A (en)1999-08-172002-07-09Biogen Inc Use of the baff receptor (bcma) as an immunoregulatory agent
US7125978B1 (en)1999-10-042006-10-24Medicago Inc.Promoter for regulating expression of foreign genes
KR100797667B1 (en)1999-10-042008-01-23메디카고 인코포레이티드 How to regulate transcription of foreign genes
UA74798C2 (en)1999-10-062006-02-15Байоджен Айдек Ма Інк.Method for treating cancer in mammals using polypeptide interfering with interaction between april and its receptors
EP1229125A4 (en)1999-10-192005-06-01Kyowa Hakko Kogyo Kk PROCESS FOR PRODUCING A POLYPEPTIDE
US6979546B2 (en)1999-11-152005-12-27Universita Di GenovaTriggering receptor involved in natural cytotoxicity mediated by human natural killer cells and antibodies that identify the same
ATE423848T1 (en)1999-11-152009-03-15Innate Pharma TRIGGER RECEPTOR INVOLVED IN THE NATURAL CYTOTOXICITY OF HUMAN NATURAL KILLER CELLS AND ANTIBODIES THAT IDENTIFY THIS RECEPTOR
US7105149B1 (en)1999-11-292006-09-12The Trustees Of Columbia University In The City Of New YorkIsolation of five novel genes coding for new Fc receptors-type melanoma involved in the pathogenesis of lymphoma/myeloma
JP2003516755A (en)1999-12-152003-05-20ジェネンテック・インコーポレーテッド Shotgun scanning, a combined method for mapping functional protein epitopes
NZ518764A (en)1999-12-292004-02-27Immunogen IncCytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use
WO2001053354A2 (en)2000-01-202001-07-26Chiron CorporationMethods for treating tumors using a fusion protein comprising il-2- polypeptides and p185-specific binding molecules
US20040002068A1 (en)2000-03-012004-01-01Corixa CorporationCompositions and methods for the detection, diagnosis and therapy of hematological malignancies
KR20020093029A (en)2000-04-112002-12-12제넨테크, 인크.Multivalent Antibodies And Uses Therefor
WO2001090192A2 (en)2000-05-242001-11-29Imclone Systems IncorporatedBispecific immunoglobulin-like antigen binding proteins and method of production
PT1297017E (en)2000-06-192012-09-04Gen Hospital Corp COMPOSITIONS AND METHODS OF MONOCLONAL AND POLYCLONAL ANTIBODIES SPECIFIC TO T-CELL SUBPOPULATIONS
CA2410551A1 (en)2000-06-302002-01-10Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw (Vib)Heterodimeric fusion proteins
IL137419A0 (en)2000-07-202001-07-24Yissum Res Dev CoNk cells activating receptors and their therapeutic and diagnostic uses
CA2417185A1 (en)2000-07-252002-01-31Shui-On LeungMultivalent target binding protein
EA013563B1 (en)2000-10-062010-06-30Киова Хакко Кирин Ко., Лтд.A transgenic non-human animal, producing antibodies with modified sugar chains, a process for producing antibodies composition and a medicament comprising the antibodies
US7064191B2 (en)2000-10-062006-06-20Kyowa Hakko Kogyo Co., Ltd.Process for purifying antibody
US6946292B2 (en)2000-10-062005-09-20Kyowa Hakko Kogyo Co., Ltd.Cells producing antibody compositions with increased antibody dependent cytotoxic activity
CN1308447C (en)2000-10-202007-04-04中外制药株式会社 Low molecular weight agonist antibody
US6596541B2 (en)2000-10-312003-07-22Regeneron Pharmaceuticals, Inc.Methods of modifying eukaryotic cells
ES2405944T3 (en)2000-11-302013-06-04Medarex, Inc. Nucleic acids encoding reorganized human immunoglobulin sequences from transgenic transchromosomal micezadas
US7829084B2 (en)2001-01-172010-11-09Trubion Pharmaceuticals, Inc.Binding constructs and methods for use thereof
CA2440358C (en)2001-03-052013-08-20Wangxia WangDenaturant stable and/or protease resistant, chaperone-like oligomeric proteins, polynucleotides encoding same and their uses
AU2002247826A1 (en)2001-03-132002-09-24University College LondonSpecific binding members
US20040175756A1 (en)2001-04-262004-09-09Avidia Research InstituteMethods for using combinatorial libraries of monomer domains
US20050048512A1 (en)2001-04-262005-03-03Avidia Research InstituteCombinatorial libraries of monomer domains
US20050053973A1 (en)2001-04-262005-03-10Avidia Research InstituteNovel proteins with targeted binding
ES2437875T3 (en)2001-04-302014-01-14Eli Lilly And Company Humanized antibodies that recognize the beta-amyloid peptide
EP1399484B1 (en)2001-06-282010-08-11Domantis LimitedDual-specific ligand and its use
US6833441B2 (en)2001-08-012004-12-21Abmaxis, Inc.Compositions and methods for generating chimeric heteromultimers
NZ592087A (en)2001-08-032012-11-30Roche Glycart AgAntibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
EP2281837B1 (en)2001-08-102016-10-05Aberdeen UniversityAntigen binding domains from fish
ES2276735T3 (en)2001-09-142007-07-01Affimed Therapeutics Ag SINGLE CHAIN MULTIMERIC FV ANTIBODIES IN TANDEM.
US7084257B2 (en)*2001-10-052006-08-01Amgen Inc.Fully human antibody Fab fragments with human interferon-gamma neutralizing activity
PL213948B1 (en)2001-10-252013-05-31Genentech IncGlycoprotein compositions
MXPA04005266A (en)2001-12-042004-10-11Merck Patent GmbhImmunocytokines with modulated selectivity.
US20030211078A1 (en)2001-12-072003-11-13Heavner George A.Pseudo-antibody constructs
US20040093621A1 (en)2001-12-252004-05-13Kyowa Hakko Kogyo Co., LtdAntibody composition which specifically binds to CD20
EP2359685B1 (en)2001-12-272013-12-04GlycoFi, Inc.Methods to engineer mammalian-type carbohydrate structures
WO2003061570A2 (en)2002-01-162003-07-31Zyomyx, Inc.Engineered binding proteins
AU2003221256A1 (en)2002-02-212003-09-09Biogen Idec Ma Inc.Use of bcma as an immunoregulatory agent
US20040018557A1 (en)2002-03-012004-01-29Immunomedics, Inc.Bispecific antibody point mutations for enhancing rate of clearance
JPWO2003085119A1 (en)2002-04-092005-08-11協和醗酵工業株式会社 Method for enhancing binding activity of antibody composition to Fcγ receptor IIIa
ES2362419T3 (en)2002-04-092011-07-05Kyowa Hakko Kirin Co., Ltd. CELLS WITH DEPRESSION OR DELETION OF THE ACTIVITY OF THE PROTEIN THAT PARTICIPATES IN THE TRANSPORT OF GDP-FUCOSA.
AU2003236015A1 (en)2002-04-092003-10-20Kyowa Hakko Kirin Co., Ltd.Process for producing antibody composition
EP1502603A4 (en)2002-04-092006-12-13Kyowa Hakko Kogyo Kk MEDICAMENT CONTAINING ANTIBODY COMPOSITION APPROPRIATE TO PATIENT SUFFERING FROM POLYMORPHISM FC gammma RIIIA
CA2481920A1 (en)2002-04-092003-10-16Kyowa Hakko Kogyo Co., Ltd.Antibody composition-containing medicament
PL373256A1 (en)2002-04-092005-08-22Kyowa Hakko Kogyo Co, Ltd.Cells with modified genome
EP1500665B1 (en)2002-04-152011-06-15Chugai Seiyaku Kabushiki KaishaMETHODS FOR CONSTRUCTING scDb LIBRARIES
JP2006506954A (en)2002-04-292006-03-02ゲンパト77 ファーマコジェネティクス エージー Novel antibodies that bind to TCR and TIRC7 and their use in therapy and diagnosis
US7829289B2 (en)2002-05-142010-11-09Institut National De La Sante Et De Recherche MedicaleT cell subpopulation regulating gut immunity
CA2488441C (en)2002-06-032015-01-27Genentech, Inc.Synthetic antibody phage libraries
US7906118B2 (en)2005-04-062011-03-15Ibc Pharmaceuticals, Inc.Modular method to prepare tetrameric cytokines with improved pharmacokinetics by the dock-and-lock (DNL) technology
ATE328906T1 (en)2002-06-282006-06-15Domantis Ltd DUAL-SPECIFIC LIGANDS WITH INCREASED HALF-LIFE
CA2872136C (en)2002-07-182017-06-20Merus B.V.Recombinant production of mixtures of antibodies
WO2004024927A1 (en)2002-09-122004-03-25Greenovation Biotech GmbhProtein production method
AU2003271904B2 (en)2002-10-092009-03-05Adaptimmune LimitedSingle chain recombinant T cell receptors
US7361740B2 (en)2002-10-152008-04-22Pdl Biopharma, Inc.Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
WO2004053054A2 (en)2002-12-092004-06-24Natspears Ltd.Nk cell receptor conjugates for treating malignancies
EP2301966A1 (en)2002-12-162011-03-30Genentech, Inc.Immunoglobulin variants and uses thereof
US7781197B2 (en)2002-12-202010-08-24Greenovation Biotech GmbhTransformed bryophyte cell having disrupted endogenous alpha 1,3-fucosyl and beta 1,2-xylosyl transferase encoding nucleotide sequences for the production of heterologous glycosylated proteins
DE10261223A1 (en)*2002-12-202004-07-08MedInnova Gesellschaft für medizinische Innovationen aus akademischer Forschung mbH Increasing the immune response through substances that influence the function of natural killer cells
US7488802B2 (en)2002-12-232009-02-10WyethAntibodies against PD-1
US20080063717A1 (en)2002-12-232008-03-13Innate Pharma, S.A.S.Pharmaceutical Compositions Having an Effect on the Proliferation of Nk Cells and a Method Using the Same
GB0230203D0 (en)2002-12-272003-02-05Domantis LtdFc fusion
JP2006523090A (en)2002-12-272006-10-12ドマンティス リミテッド Bispecific single domain antibody specific for ligand and for ligand receptor
JP2006524039A (en)2003-01-092006-10-26マクロジェニクス,インコーポレーテッド Identification and production of antibody containing mutant Fc region and use thereof
EP1585767A2 (en)2003-01-162005-10-19Genentech, Inc.Synthetic antibody phage libraries
DE602004028337D1 (en)2003-01-222010-09-09Glycart Biotechnology Ag FUSION CONSTRUCTS AND ITS USE IN ANTIBODY PRODUCTION WITH INCREASED FC RECEPTOR BINDING SAFFINITY AND EFFECTOR FUNCTION
US20060104968A1 (en)2003-03-052006-05-18Halozyme, Inc.Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
US7871607B2 (en)2003-03-052011-01-18Halozyme, Inc.Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
CN1942588B (en)2003-03-052013-06-12海洋酶公司 Soluble hyaluronidase glycoproteins (sHASEGP), methods for their preparation, their use and pharmaceutical compositions comprising them
GB0305702D0 (en)2003-03-122003-04-16Univ BirminghamBispecific antibodies
US7700317B2 (en)2003-03-282010-04-20Biogen Idec Ma Inc.Truncated baff receptors
EP1618181B1 (en)2003-04-222014-10-15IBC PharmaceuticalsPolyvalent protein complex
WO2005000901A2 (en)2003-05-092005-01-06Duke UniversityCd20-specific antibodies and methods of employing same
WO2005028517A2 (en)2003-05-092005-03-31The General Hospital CorporationSOLUBLE TGF-β TYPE III RECEPTOR FUSION PROTEINS
CA2525120C (en)2003-05-142013-04-30Domantis LimitedA process for recovering polypeptides that unfold reversibly from a polypeptide repertoire
US20070105105A1 (en)2003-05-232007-05-10Mount Sinai School Of Medicine Of New York UniversitySurrogate cell gene expression signatures for evaluating the physical state of a subject
DE10324447A1 (en)2003-05-282004-12-30Scil Proteins Gmbh Generation of artificial binding proteins based on ubiquitin
EP2395016A3 (en)2003-05-302012-12-19Merus B.V.Design and use of paired variable regions of specific binding molecules
WO2005000898A2 (en)2003-06-272005-01-06Biogen Idec Ma Inc.Use of hydrophobic-interaction-chromatography or hinge-region modifications for the production of homogeneous antibody-solutions
ES2315664T3 (en)2003-06-302009-04-01Domantis Limited SINGLE-DOMAIN ANTIBODIES (DAB) PEGILATED.
JP5026072B2 (en)2003-07-012012-09-12イミューノメディクス、インコーポレイテッド Multispecific carrier of bispecific antibody
CA2532547C (en)2003-07-242020-02-25Innate PharmaMethods and compositions for increasing the efficiency of therapeutic antibodies using nk cell potentiating compounds
US7696322B2 (en)2003-07-282010-04-13Catalent Pharma Solutions, Inc.Fusion antibodies
US20080241884A1 (en)2003-10-082008-10-02Kenya ShitaraFused Protein Composition
US20070134759A1 (en)2003-10-092007-06-14Harue NishiyaProcess for producing antibody composition by using rna inhibiting the function of alpha1,6-fucosyltransferase
KR20070001880A (en)2003-10-202007-01-04바이오겐 아이덱 엠에이 인코포레이티드 Therapeutic regimens for BΑFF antagonists
DE602004026470D1 (en)2003-11-052010-05-20Roche Glycart Ag FC RECEPTOR AND EFFECTOR FUNCTION
EP3858387A1 (en)2003-11-062021-08-04Seagen Inc.Monomethylvaline compounds capable of conjugation to ligands
JPWO2005053742A1 (en)2003-12-042007-06-28協和醗酵工業株式会社 Medicament containing antibody composition
US20050136051A1 (en)2003-12-222005-06-23Bernard ScallonMethods for generating multimeric molecules
GB0329825D0 (en)2003-12-232004-01-28Celltech R&D LtdBiological products
US20050266425A1 (en)2003-12-312005-12-01Vaccinex, Inc.Methods for producing and identifying multispecific antibodies
US8383575B2 (en)2004-01-302013-02-26Paul Scherrer Institut(DI)barnase-barstar complexes
WO2006107617A2 (en)2005-04-062006-10-12Ibc Pharmaceuticals, Inc.Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses
KR20060132006A (en)2004-03-232006-12-20비오겐 아이덱 엠에이 아이엔씨. Receptor Coupling Agents and Their Therapeutic Uses
CN1961003B (en)2004-03-312013-03-27健泰科生物技术公司Humanized anti-TGF-beta antibodies
US7785903B2 (en)2004-04-092010-08-31Genentech, Inc.Variable domain library and uses
PL1737891T3 (en)2004-04-132013-08-30Hoffmann La RocheAnti-p-selectin antibodies
JP2008502322A (en)2004-04-302008-01-31イネイト・ファーマ Compositions and methods for enhancing NK cell activity
JP2008502597A (en)2004-04-302008-01-31イネイト・ファーマ Compositions and methods for treating immunoproliferative disorders such as NK-type LDGL
US7501121B2 (en)2004-06-172009-03-10WyethIL-13 binding agents
US20060008844A1 (en)2004-06-172006-01-12Avidia Research Institutec-Met kinase binding proteins
US8361794B2 (en)2004-06-292013-01-29Immunocore LimitedCells expressing a modified T cell receptor
JP2008512352A (en)2004-07-172008-04-24イムクローン システムズ インコーポレイティド Novel tetravalent bispecific antibody
NZ552485A (en)2004-08-052009-11-27Genentech IncHumanized anti-cmet antagonists
CA2577082A1 (en)2004-09-022006-03-16Genentech, Inc.Heteromultimeric molecules
TWI309240B (en)2004-09-172009-05-01Hoffmann La RocheAnti-ox40l antibodies
WO2006034488A2 (en)2004-09-232006-03-30Genentech, Inc.Cysteine engineered antibodies and conjugates
CA2580796C (en)2004-09-242013-03-26Amgen Inc.Modified fc molecules having peptides inserted in internal loop regions
WO2006039238A2 (en)2004-09-302006-04-13The Goverment Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human ServicesIrta2 antibodies and methods of use
JO3000B1 (en)2004-10-202016-09-05Genentech IncAntibody Formulations.
ES2342964T3 (en)2004-12-092010-07-20Merck Patent Gmbh VARIATIONS OF INTERLEUCINE-7 WITH REDUCED IMMUNOGENICITY.
KR20070115881A (en)2005-01-122007-12-06메다렉스, 인코포레이티드 AIArtie-2 antibody and uses thereof
CA2595959A1 (en)2005-01-272006-08-03Novartis Vaccines And Diagnostics, Inc.Methods for treating renal cell carcinoma
CA2595682A1 (en)2005-01-312006-08-03Ablynx N.V.Method for generating variable domain sequences of heavy chain antibodies
US7431380B1 (en)2005-02-242008-10-07Theodore Allen BureshLouver kit
WO2006106905A1 (en)2005-03-312006-10-12Chugai Seiyaku Kabushiki KaishaProcess for production of polypeptide by regulation of assembly
EP3479844B1 (en)2005-04-152023-11-22MacroGenics, Inc.Covalent diabodies and uses thereof
KR20080013878A (en)2005-04-182008-02-13노보 노르디스크 에이/에스 IL-21 variants
CA3151350A1 (en)2005-05-092006-11-16E. R. Squibb & Sons, L.L.C.Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics
US20060263367A1 (en)2005-05-232006-11-23Fey Georg HBispecific antibody devoid of Fc region and method of treatment using same
WO2006135886A2 (en)2005-06-132006-12-21The Regents Of The University Of MichiganCompositions and methods for treating and diagnosing cancer
JP2006345852A (en)2005-06-162006-12-28Virxsys CorpAntibody conjugate
CN103145838A (en)2005-06-302013-06-12Abbvie公司IL-12/p40 binding proteins
CA3201163A1 (en)2005-07-012007-01-11E. R. Squibb & Sons, L.L.C.Human monoclonal antibodies to programmed death ligand 1 (pd-l1)
DK1917029T3 (en)2005-07-272013-04-29Lilly Co Eli Process for treating cancer cells and creating a modified cancer cell that provokes an immunogenic response
US7612181B2 (en)2005-08-192009-11-03Abbott LaboratoriesDual variable domain immunoglobulin and uses thereof
DE602005018477D1 (en)2005-08-262010-02-04Pls Design Gmbh Bivalent IgY antibody constructs for diagnostic and therapeutic applications
WO2007027714A2 (en)2005-08-312007-03-08Schering CorporationEngineered anti-il-23 antibodies
WO2007039507A2 (en)2005-09-232007-04-12Novo Nordisk A/SMethods of identifying antibodies to ligands of orphan receptors
WO2007044887A2 (en)2005-10-112007-04-19Transtarget, Inc.Method for producing a population of homogenous tetravalent bispecific antibodies
CA2625222A1 (en)2005-10-112007-04-19Domantis LimitedAntibody polypeptide library screening and selected antibody polypeptides
US8617545B2 (en)2005-10-132013-12-31Biogen Idec Ma Inc.Methods for use with BAFF antagonists
US9447185B2 (en)2005-10-142016-09-20Innate Pharma, S.A.Compositions and methods for treating proliferative disorders
US20080299137A1 (en)2005-10-282008-12-04Novo Nordisk A/SFusion Proteins That Bind Effector Lymphocytes And Target Cells
ES2577292T3 (en)2005-11-072016-07-14Genentech, Inc. Binding polypeptides with diversified VH / VL hypervariable sequences and consensus
SG10201600950TA (en)2005-11-282016-03-30Genmab AsRecombinant monovalent antibodies and methods for production thereof
US8623356B2 (en)2005-11-292014-01-07The University Of SydneyDemibodies: dimerization-activated therapeutic agents
US20070237764A1 (en)2005-12-022007-10-11Genentech, Inc.Binding polypeptides with restricted diversity sequences
CA2638794A1 (en)2006-02-152007-08-23Imclone Systems IncorporatedFunctional antibodies
JP2009529027A (en)2006-03-082009-08-13ビオメトード Human interferon gamma (IFNγ) mutant
AU2007227292B2 (en)2006-03-172012-04-12Biogen Ma Inc.Stabilized polypeptide compositions
WO2007112362A2 (en)2006-03-242007-10-04The Regents Of The University Of CaliforniaConstruction of a multivalent scfv through alkyne-azide 1,3-dipolar cycloaddition
EP1999154B1 (en)2006-03-242012-10-24Merck Patent GmbHEngineered heterodimeric protein domains
EP2009101B1 (en)2006-03-312017-10-25Chugai Seiyaku Kabushiki KaishaAntibody modification method for purifying bispecific antibody
JP2009536527A (en)2006-05-092009-10-15ジェネンテック・インコーポレーテッド Binding polypeptide with optimized scaffold
EP2027153B1 (en)2006-05-252014-04-30Bayer Intellectual Property GmbHDimeric molecular complexes
US20070274985A1 (en)2006-05-262007-11-29Stefan DubelAntibody
EP3805269A1 (en)2006-06-122021-04-14Aptevo Research and Development LLCSingle-chain multivalent binding proteins with effector function
WO2008017859A2 (en)2006-08-102008-02-14Isis Innovation LimitedLigand for the g6b receptor on blood platelets
WO2008073160A2 (en)2006-08-172008-06-19The Trustees Of Columbia University In The City Of New YorkMethods for converting or inducing protective immunity
US8497246B2 (en)2006-08-182013-07-30Armagen Technologies, Inc.Methods for diagnosing and treating CNS disorders by trans-blood-brain barrier delivery of protein compositions
WO2008027236A2 (en)2006-08-302008-03-06Genentech, Inc.Multispecific antibodies
DK2069381T3 (en)2006-09-132016-03-14Univ Columbia Anti-tumor immune response triggering agents and methods
CN101965363A (en)2006-11-022011-02-02丹尼尔·J·卡鹏 Hybrid immunoglobulin with active part
US20080226635A1 (en)2006-12-222008-09-18Hans KollAntibodies against insulin-like growth factor I receptor and uses thereof
WO2008087219A1 (en)2007-01-192008-07-24INSERM (Institut National de la Santé et de la Recherche Médicale)Compositions and methods for regulating t cell activity
ES2667863T3 (en)2007-03-292018-05-14Genmab A/S Bispecific antibodies and their production methods
WO2008131242A1 (en)2007-04-182008-10-30Zymogenetics, Inc.Single chain fc, methods of making and methods of treatment
PT2769984T (en)2007-05-112017-10-05Altor Bioscience Corp MOLECULES OF FUSION AND VARIANTS OF IL-15
WO2008144753A2 (en)2007-05-212008-11-27Alder Biopharmaceuticals, Inc.Antibodies to tnf alpha and use thereof
CN100592373C (en)2007-05-252010-02-24群康科技(深圳)有限公司 Liquid crystal display panel driving device and driving method thereof
CN102131828B (en)2007-06-182015-06-17默沙东有限责任公司 Antibody against human programmed death receptor PD-1
EP2014680A1 (en)2007-07-102009-01-14Friedrich-Alexander-Universität Erlangen-NürnbergRecombinant, single-chain, trivalent tri-specific or bi-specific antibody derivatives
AU2008282218A1 (en)2007-07-312009-02-05Medimmune, LlcMultispecific epitope binding proteins and uses thereof
EP2178914A2 (en)2007-08-152010-04-28Bayer Schering Pharma AktiengesellschaftMonospecific and multispecific antibodies and method of use
ES2566957T3 (en)2007-09-262016-04-18Chugai Seiyaku Kabushiki Kaisha Constant region of modified antibody
JP5496897B2 (en)2007-10-042014-05-21ザイモジェネティクス, インコーポレイテッド B7 family member zB7H6 and related compositions and methods
CA2705292C (en)2007-11-132016-06-21Teva Biopharmaceuticals Usa, Inc.Humanized antibodies against tl1a
BRPI0819656A2 (en)2007-11-272015-06-23Ablynx Nv Amino acid sequences against heterodimeric cytokines and / or their receptors and polypeptides comprising the same
CA2706419A1 (en)2007-11-302009-06-04Glaxo Group LimitedAntigen-binding constructs binding il-13
KR20130087632A (en)2007-12-172013-08-06화이자 리미티드Treatment of interstitial cystitis
US20090162359A1 (en)2007-12-212009-06-25Christian KleinBivalent, bispecific antibodies
US9266967B2 (en)2007-12-212016-02-23Hoffmann-La Roche, Inc.Bivalent, bispecific antibodies
US8227577B2 (en)2007-12-212012-07-24Hoffman-La Roche Inc.Bivalent, bispecific antibodies
US8242247B2 (en)2007-12-212012-08-14Hoffmann-La Roche Inc.Bivalent, bispecific antibodies
PL2235064T3 (en)2008-01-072016-06-30Amgen IncMethod for making antibody fc-heterodimeric molecules using electrostatic steering effects
CN101970499B (en)2008-02-112014-12-31治疗科技公司 Monoclonal Antibodies for Cancer Therapy
CA2712474A1 (en)2008-02-212009-08-27Baxter Healthcare S.A.Procedure for the generation of a high producer cell line for the expression of a recombinant anti-cd34 antibody
US8168757B2 (en)2008-03-122012-05-01Merck Sharp & Dohme Corp.PD-1 binding proteins
WO2010031168A1 (en)2008-09-172010-03-25National Research Council Of CanadaHETERO-MULTIVALENT BINDING AGENTS FOR MEMBERS OF THE TGFβ SUPERFAMILY
CN107469077A (en)2008-04-112017-12-15中外制药株式会社The antigen binding molecules combined repeatedly with the antigen of multiple molecules
EP2285980B1 (en)2008-06-022017-05-17Institut Gustave RoussyNATURAL KILLER p30 (NKp30) DYSFUNCTION AND THE BIOLOGICAL APPLICATIONS THEREOF
AR072999A1 (en)2008-08-112010-10-06Medarex Inc HUMAN ANTIBODIES THAT JOIN GEN 3 OF LYMPHOCYTARY ACTIVATION (LAG-3) AND THE USES OF THESE
US20110223188A1 (en)2008-08-252011-09-15Solomon LangermannTargeted costimulatory polypeptides and methods of use to treat cancer
EP2927240A1 (en)2008-08-252015-10-07Amplimmune, Inc.Compositions of pd-1 antagonists and methods of use
AU2009288354A1 (en)2008-08-262010-03-11Macrogenics Inc.T-cell receptor antibodies and methods of use thereof
TWI516501B (en)2008-09-122016-01-11禮納特神經系統科學公司Pcsk9 antagonists
PT4209510T (en)2008-12-092024-04-02Hoffmann La RocheAnti-pd-l1 antibodies and their use to enhance t-cell function
US8580267B2 (en)2008-12-192013-11-12Philogen S.P.A.Immunocytokines for tumour therapy with chemotherapeutic agents
EP3192811A1 (en)2009-02-092017-07-19Université d'Aix-MarseillePd-1 antibodies and pd-l1 antibodies and uses thereof
PL2406284T3 (en)2009-03-102017-09-29Biogen Ma Inc.Anti-bcma antibodies
CN102369218B (en)2009-04-012014-07-16霍夫曼-拉罗奇有限公司Anti-fcrh5 antibodies and immunoconjugates and methods of use
JP6132548B2 (en)2009-04-012017-05-24ジェネンテック, インコーポレイテッド Anti-FcRH5 antibodies and immunoconjugates and methods of use
EP2414391B1 (en)2009-04-022018-11-28Roche Glycart AGMultispecific antibodies comprising full length antibodies and single chain fab fragments
PT2417156E (en)2009-04-072015-04-29Roche Glycart AgTrivalent, bispecific antibodies
US9067986B2 (en)2009-04-272015-06-30Oncomed Pharmaceuticals, Inc.Method for making heteromultimeric molecules
US9676845B2 (en)2009-06-162017-06-13Hoffmann-La Roche, Inc.Bispecific antigen binding proteins
US8703132B2 (en)2009-06-182014-04-22Hoffmann-La Roche, Inc.Bispecific, tetravalent antigen binding proteins
PL2975051T3 (en)2009-06-262021-09-20Regeneron Pharmaceuticals, Inc.Readily isolated bispecific antibodies with native immunoglobulin format
WO2011008502A2 (en)2009-06-292011-01-20California Institute Of TechnologyIsolation of unknown rearranged t-cell receptors from single cells
WO2011020783A2 (en)2009-08-172011-02-24Roche Glycart AgTargeted immunoconjugates
CN102612524A (en)2009-09-012012-07-25雅培制药有限公司Dual variable domain immunoglobulins and uses thereof
US9493578B2 (en)2009-09-022016-11-15Xencor, Inc.Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
IT1395574B1 (en)2009-09-142012-10-16Guala Dispensing Spa DISTRIBUTION DEVICE
AU2010321720B2 (en)2009-11-232017-03-02Amgen Inc.Monomeric antibody Fc
JP2013512251A (en)2009-11-242013-04-11アンプリミューン、インコーポレーテッド Simultaneous inhibition of PD-L1 / PD-L2
KR20120123299A (en)2009-12-042012-11-08제넨테크, 인크.Multispecific antibodies, antibody analogs, compositions, and methods
PT2510011E (en)2009-12-092014-12-12Inst Nat Santé Et De La Rech MédicaleMonoclonal antibodies that bind b7h6 and uses thereof
EA022984B1 (en)2009-12-292016-04-29Эмерджент Продакт Дивелопмент Сиэтл, ЛлсRon binding constructs and methods of use thereof
US20130129723A1 (en)2009-12-292013-05-23Emergent Product Development Seattle, LlcHeterodimer Binding Proteins and Uses Thereof
US20120294857A1 (en)2010-01-112012-11-22Trustees Of Dartmouth CollegeMonomeric Bi-Specific Fusion Protein
SI2530091T1 (en)2010-01-292018-06-29Chugai Seiyaku Kabushiki KaishaAnti-dll3 antibody
EP3798237A1 (en)2010-03-052021-03-31The Johns Hopkins UniversityCompositions and methods for targeted immunomodulatory antibodies and fusion proteins
AR080793A1 (en)2010-03-262012-05-09Roche Glycart Ag BISPECIFIC ANTIBODIES
KR101930964B1 (en)2010-04-202018-12-19젠맵 에이/에스Heterodimeric antibody fc-containing proteins and methods for production thereof
JP2013534520A (en)2010-06-082013-09-05ジェネンテック, インコーポレイテッド Cysteine engineered antibodies and conjugates
PT2581113T (en)2010-06-112018-07-04Univ Kyushu Nat Univ CorpAnti-tim-3 antibody
WO2012012737A2 (en)2010-07-232012-01-26The University Of ToledoStable tregs and related materials and methods
DK2606064T3 (en)2010-08-162015-04-20Novimmune Sa Methods for generating multispecific and multivalent antibodies
CA2807278A1 (en)2010-08-242012-03-01F. Hoffmann - La Roche AgBispecific antibodies comprising a disulfide stabilized - fv fragment
CN103068847B (en)2010-08-242019-05-07罗切格利卡特公司 Activatable Bispecific Antibodies
CN101985476B (en)*2010-10-292012-11-21中国科学技术大学Preparation, identification and application of antihuman NKp30 monoclonal antibody
KR101973930B1 (en)2010-11-052019-04-29자임워크스 인코포레이티드Stable heterodimeric antibody design with mutations in the fc domain
JP2014500879A (en)2010-11-162014-01-16ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Factors and methods for treating diseases correlated with BCMA expression
PH12013501201A1 (en)2010-12-092013-07-29Univ PennsylvaniaUse of chimeric antigen receptor-modified t cells to treat cancer
US20140271683A1 (en)2010-12-212014-09-18The Board Of Trustees Of The Leland Stanford Junior UniversityTherapeutic and Diagnostic Methods for Manipulating Phagocytosis Through Calreticulin and Low Density Lipoprotein-Related Receptor
EP2654792A4 (en)2010-12-222016-05-11Abbvie IncHalf immunoglobulin binding proteins and uses thereof
US10689447B2 (en)2011-02-042020-06-23Genentech, Inc.Fc variants and methods for their production
JP5878182B2 (en)2011-02-102016-03-08ロシュ グリクアート アーゲー Mutant interleukin-2 polypeptide
WO2012118622A1 (en)2011-02-192012-09-07Baylor Research InstituteDiagnostic and therapeutic uses for b cell maturation antigen
WO2012118903A2 (en)2011-03-012012-09-07Amgen Inc.Bispecific binding agents
EA201791693A1 (en)2011-03-252018-05-31Гленмарк Фармасьютикалс С.А. HETERODIMERNY IMMUNOHLOBULINS
PT2694549T (en)2011-04-082018-11-22Us HealthAnti-epidermal growth factor receptor variant iii chimeric antigen receptors and use of same for the treatment of cancer
US20130101599A1 (en)2011-04-212013-04-25Boehringer Ingelheim International GmbhBcma-based stratification and therapy for multiple myeloma patients
EA201892619A1 (en)2011-04-292019-04-30Роше Гликарт Аг IMMUNOCONJUGATES CONTAINING INTERLEUKIN-2 MUTANT POLYPETIPS
CN107903325B (en)2011-05-162021-10-29埃泰美德(香港)有限公司 Multispecific FAB fusion proteins and methods of use
US9574002B2 (en)*2011-06-062017-02-21Amgen Inc.Human antigen binding proteins that bind to a complex comprising β-Klotho and an FGF receptor
CA2838340A1 (en)2011-06-172012-12-20Amgen Inc.Method of treating or ameliorating metabolic disorders using clec-2
EP3626739A1 (en)2011-06-242020-03-25Stephen D. GilliesLight chain immunoglobulin fusion proteins and methods of use thereof
US9890218B2 (en)2011-06-302018-02-13Chugai Seiyaku Kabushiki KaishaHeterodimerized polypeptide
UA117901C2 (en)2011-07-062018-10-25Ґенмаб Б.В. METHOD FOR STRENGTHENING THE EFFECTORAL FUNCTION OF THE ORIGINAL POLYEPEPTIDE, ITS OPTIONS AND THEIR APPLICATIONS
CN107266584B (en)2011-07-292022-05-13宾夕法尼亚大学董事会Transducible co-stimulatory receptors
SI2748201T1 (en)2011-08-232018-03-30Roche Glycart AgBispecific t cell activating antigen binding molecules
WO2013033626A2 (en)*2011-08-312013-03-07Trustees Of Dartmouth CollegeNkp30 receptor targeted therapeutics
UY34317A (en)2011-09-122013-02-28Genzyme Corp T cell antireceptor antibody (alpha) / ß
CA2791109C (en)2011-09-262021-02-16Merus B.V.Generation of binding molecules
EP2768857B1 (en)2011-10-192020-01-01NovImmune SAMethods of purifying antibodies
EA037797B1 (en)2011-10-252021-05-21Протена Байосайенсиз ЛимитедAntibody formulation useful for prophylaxis and treatment of amyloidosis, variants thereof and method of making same
JP6475017B2 (en)2011-10-272019-02-27ゲンマブ エー/エス Production of heterodimeric protein
US20130273089A1 (en)2011-11-032013-10-17Tolera Therapeutics, Inc.Antibody and methods for selective inhibition of t-cell responses
KR102052774B1 (en)2011-11-042019-12-04자임워크스 인코포레이티드Stable heterodimeric antibody design with mutations in the fc domain
TWI679212B (en)2011-11-152019-12-11美商安進股份有限公司Binding molecules for e3 of bcma and cd3
AU2012344260B2 (en)2011-11-282017-09-07Merck Patent GmbhAnti-PD-L1 antibodies and uses thereof
CA2859767C (en)2011-12-192018-09-11Synimmune GmbhBispecific antibody molecule and use thereof for treatment of proliferative disease
ES2816078T3 (en)2011-12-202021-03-31Medimmune Llc Modified Polypeptides for Bispecific Antibody Scaffolds
AU2012362378B2 (en)2011-12-272016-06-23Dcb-Usa LlcLight chain-bridged bispecific antibody
AU2013207407A1 (en)2012-01-052013-10-24Visa International Service AssociationTransaction visual capturing apparatuses, methods and systems
RU2644341C2 (en)2012-02-102018-02-08Дженентек, Инк.Single-chain antibodies and other heteromultimers
GB201203051D0 (en)2012-02-222012-04-04Ucb Pharma SaBiological products
JP6089047B2 (en)2012-02-242017-03-01アッヴィ・ステムセントルクス・エル・エル・シー DLL3 modulator and method of use
PT2825559T (en)2012-03-132019-06-07Novimmune SaReadily isolated bispecific antibodies with native immunoglobulin format
MY198567A (en)2012-03-142023-09-05Regeneron PharmaMultispecific antigen-binding molecules and uses thereof
CN114163530B (en)2012-04-202025-04-29美勒斯公司 Methods and means for producing immunoglobulin-like molecules
US20130336973A1 (en)2012-05-102013-12-19Zymeworks Inc.Heteromultimer Constructs of Immunoglobulin Heavy Chains with Mutations in the Fc Domain
AU2013259276B2 (en)2012-05-102018-03-22Bioatla LlcMulti-specific monoclonal antibodies
CA2869529A1 (en)2012-05-242013-11-28Raffaella CASTOLDIMultispecific antibodies
WO2014004586A1 (en)2012-06-252014-01-03Zymeworks Inc.Process and methods for efficient manufacturing of highly pure asymmetric antibodies in mammalian cells
CN104395340B9 (en)2012-06-272018-11-30弗·哈夫曼-拉罗切有限公司 Method of tailoring selective and multispecific therapeutic molecules comprising at least two different targeting entities and uses thereof
UY34887A (en)2012-07-022013-12-31Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware OPTIMIZATION OF ANTIBODIES THAT FIX THE LYMPHOCYTE ACTIVATION GEN 3 (LAG-3) AND ITS USES
EP2869845B1 (en)2012-07-062019-08-28Genmab B.V.Dimeric protein with triple mutations
CN104640561A (en)2012-07-232015-05-20酵活有限公司 Immunoglobulin constructs comprising selective pairing of light and heavy chains
CA2879814A1 (en)2012-08-022014-02-06Jn Biosciences LlcAntibodies or fusion proteins multimerized via cysteine mutation and a mu tailpiece
WO2014022540A1 (en)2012-08-022014-02-06Regeneron Pharmaceuticals, Inc.Multivalent antigen-binding proteins
ES2700978T3 (en)2012-08-072019-02-20Roche Glycart Ag Composition comprising two antibodies engineered to have a reduced and increased effector function
US20140044675A1 (en)2012-08-102014-02-13Roche Glycart AgInterleukin-2 fusion proteins and uses thereof
US9682143B2 (en)2012-08-142017-06-20Ibc Pharmaceuticals, Inc.Combination therapy for inducing immune response to disease
RU2663725C2 (en)2012-09-042018-08-08СеллектисMulti-chain chimeric antigen receptor and uses thereof
US20140079691A1 (en)2012-09-202014-03-20Anaptysbio, Inc.Thermostable antibody framework regions
US9771573B2 (en)2012-10-032017-09-26Zymeworks Inc.Methods of quantitating heavy and light chain polypeptide pairs
US10087250B2 (en)2012-10-082018-10-02Roche Glycart AgFc-free antibodies comprising two fab-fragments and methods of use
UY35148A (en)2012-11-212014-05-30Amgen Inc HETERODIMERIC IMMUNOGLOBULINS
US9914785B2 (en)2012-11-282018-03-13Zymeworks Inc.Engineered immunoglobulin heavy chain-light chain pairs and uses thereof
US9243058B2 (en)2012-12-072016-01-26Amgen, Inc.BCMA antigen binding proteins
EP2934577A1 (en)2012-12-192015-10-28Adimab, LLCMultivalent antibody analogs, and methods of their preparation and use
AU2013204922B2 (en)2012-12-202015-05-14Celgene CorporationChimeric antigen receptors
US9790277B2 (en)2012-12-212017-10-17The Johns Hopkins UniversityAnti-H7CR antibodies
US10766960B2 (en)2012-12-272020-09-08Chugai Seiyaku Kabushiki KaishaHeterodimerized polypeptide
JP6377635B2 (en)2013-01-102018-08-22ゲンマブ ビー.ブイ. Human IgG1 Fc region variants and uses thereof
WO2014116846A2 (en)2013-01-232014-07-31Abbvie, Inc.Methods and compositions for modulating an immune response
TWI682941B (en)2013-02-012020-01-21美商再生元醫藥公司Antibodies comprising chimeric constant domains
ES2829499T3 (en)2013-02-052021-06-01Engmab Sarl Method for the selection of antibodies against BCMA
US9989524B2 (en)2013-02-052018-06-05SanofiImmuno imaging agent for use with antibody-drug conjugate therapy
US10047163B2 (en)2013-02-082018-08-14Abbvie Stemcentrx LlcMultispecific constructs
EP2954330A4 (en)2013-02-082016-08-31Inst Myeloma & Bone Cancer ResImproved diagnostic, prognostic, and monitoring methods for multiple myeloma, chronic lymphocytic leukemia, and b-cell non-hodgkin lymphoma
GB201302447D0 (en)2013-02-122013-03-27Oxford Biotherapeutics LtdTherapeutic and diagnostic target
US9573988B2 (en)2013-02-202017-02-21Novartis AgEffective targeting of primary human leukemia using anti-CD123 chimeric antigen receptor engineered T cells
WO2014130879A2 (en)2013-02-222014-08-28Stem Centrx, Inc.Novel antibody conjugates and uses thereof
EP2961773B1 (en)2013-02-262019-03-20Roche Glycart AGBispecific t cell activating antigen binding molecules
JP6420776B2 (en)2013-03-052018-11-07ベイラー カレッジ オブ メディスンBaylor College Of Medicine Engager cells for immunotherapy
RS62304B1 (en)2013-03-142021-09-30Macrogenics Inc BISPECIFIC MOLECULES WHICH ARE IMMUNOREACTIVE WITH IMMUNE EFFECTIVE CELLS EXPRESSING AN ACTIVATING RECEPTOR
AR095374A1 (en)2013-03-152015-10-14Amgen Res Munich Gmbh UNION MOLECULES FOR BCMA AND CD3
CN105007950B (en)2013-03-152019-01-15诺华股份有限公司 Antibody Drug Conjugates
US20140302037A1 (en)2013-03-152014-10-09Amgen Inc.BISPECIFIC-Fc MOLECULES
US10858417B2 (en)2013-03-152020-12-08Xencor, Inc.Heterodimeric proteins
US20140308285A1 (en)2013-03-152014-10-16Amgen Inc.Heterodimeric bispecific antibodies
WO2014150973A1 (en)2013-03-152014-09-25Eli Lilly And CompanyMethods for producing fabs and bi-specific antibodies
PL2992010T3 (en)2013-04-292021-08-23F.Hoffmann-La Roche AgFc-receptor binding modified asymmetric antibodies and methods of use
CA2913363A1 (en)2013-05-242014-11-27Zymeworks Inc.Modular protein drug conjugate therapeutic
BR112015029788B1 (en)2013-05-312024-01-02Zymeworks Inc HETERO-MULTIMER, USE AND METHOD FOR PREPARING THE SAME, PHARMACEUTICAL COMPOSITION AND METHOD FOR REDUCING EFFECTOR FUNCTION OF AN IgG FC CONSTRUCT
AR096687A1 (en)2013-06-242016-01-27Genentech Inc ANTI-FCRH5 ANTIBODIES
EP3019522B1 (en)2013-07-102017-12-13Sutro Biopharma, Inc.Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use
EP3705498A1 (en)2013-08-222020-09-09Acceleron Pharma Inc.Tgf-beta receptor type ii variants and uses thereof
DK2808338T3 (en)2013-09-162016-06-06Cemm - Forschungszentrum Für Molekulare Medizin GmbhMutant calreticulin for diagnosis of myeloid malignancies
KR102441231B1 (en)2013-09-272022-09-06추가이 세이야쿠 가부시키가이샤 Method for preparing polypeptide heteromultimers
GB201317928D0 (en)2013-10-102013-11-27Ucl Business PlcMolecule
EP3055329B1 (en)2013-10-112018-06-13F. Hoffmann-La Roche AGMultispecific domain exchanged common variable light chain antibodies
AU2014342182B2 (en)2013-10-302020-05-14Eberhard Karls Universitat TubingenMethods for enhancing immunosuppressive therapy by multiple administration of alpha beta TCR -binding polypeptide
RS60443B1 (en)2013-12-172020-07-31Genentech IncAnti-cd3 antibodies and methods of use
EP3082853A2 (en)2013-12-202016-10-26The Broad Institute, Inc.Combination therapy with neoantigen vaccine
MX380658B (en)2014-01-152025-03-11Hoffmann La Roche REGION FC VARIANTS WITH ENHANCED PROTEIN A BINDING.
CA2931986A1 (en)2014-01-152015-07-23F. Hoffmann-La Roche AgFc-region variants with modified fcrn- and maintained protein a-binding properties
CA2931979A1 (en)2014-01-152015-07-23F. Hoffmann-La Roche AgFc-region variants with modified fcrn-binding properties
EP3508496A1 (en)2014-02-062019-07-10F. Hoffmann-La Roche AGInterleukin-2 fusion proteins and uses thereof
US9676863B2 (en)2014-02-102017-06-13Merck Patent GmbhTargeted TGFβ inhibitors
DK3105252T3 (en)2014-02-122019-10-14Michael Uhlin BISPECIFIC ANTIBODIES FOR USE IN STEM CELL TRANSPLANTATION
HK1231374A1 (en)2014-02-212017-12-22Regeneron Pharmaceuticals, Inc.Methods, compositions and kits for cell specific modulation of target antigens
PE20161209A1 (en)2014-02-212016-11-10Abbvie Stemcentrx Llc CONJUGATES OF ANTI-DROSOPHILA SIMILAR ANTIBODIES TO DELTA 3 (ANTI-DLL3) AND DRUGS FOR USE IN THE TREATMENT OF MELANOMA
DK3125934T3 (en)2014-03-052020-02-03Ucl Business Ltd CHEMICAL ANTIGEN RECEPTOR (CAR) WITH ANTIGIN BINDING DOMAINS OVER THE CONSTANT REGION OF T-CELL RECEPTOR BETA
US11385233B2 (en)2015-03-052022-07-12Autolus LimitedMethods of depleting malignant T-cells
AU2015228844B2 (en)2014-03-112019-08-15CellectisMethod for generating T-cells compatible for allogenic transplantation
JP2017513818A (en)2014-03-152017-06-01ノバルティス アーゲー Treatment of cancer using chimeric antigen receptors
CN107172880B (en)2014-03-242021-09-28癌症研究技术有限公司Modified antibodies comprising a modified IgG2 domain that elicit agonistic or antagonistic properties and uses thereof
UA117289C2 (en)2014-04-022018-07-10Ф. Хоффманн-Ля Рош Аг MULTISPECIFIC ANTIBODY
EP2930188A1 (en)2014-04-132015-10-14Affimed Therapeutics AGTrifunctional antigen-binding molecule
WO2015164815A1 (en)2014-04-242015-10-29The Board Of Trustees Of The Leland Stanford Junior UniversitySuperagonists, partial agonists and antagonists of interleukin-2
MX375800B (en)2014-04-302025-03-06Max Delbrueck Centrum Fuer Molekulare Medizin Helmholtz Gemeinschaft HUMANIZED ANTIBODIES AGAINST CD269 (BCMA).
AU2015265457B2 (en)2014-05-282021-02-18Zymeworks Bc Inc.Modified antigen binding polypeptide constructs and uses thereof
MX375379B (en)2014-05-292025-03-06Us HealthAnti-human papillomavirus 16 e7 t cell receptors
ES2890079T3 (en)2014-05-292022-01-17Macrogenics Inc Trispecific binding molecules and methods of using same
JP6822849B2 (en)2014-06-272021-01-27イナート・ファルマ・ソシエテ・アノニムInnate Pharma Pharma S.A. Multispecific NKp46 binding protein
DK3160994T3 (en)2014-06-272025-05-05Innate Pharma MULTISPECIFIC ANTIGEN-BINDING PROTEINS
WO2015197582A1 (en)2014-06-272015-12-30Innate PharmaMonomeric multispecific antigen binding proteins
JP6744292B2 (en)2014-07-292020-08-19エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Multispecific antibody
EP2982692A1 (en)2014-08-042016-02-10EngMab AGBispecific antibodies against CD3epsilon and BCMA
KR102067092B1 (en)2014-08-042020-01-17에프. 호프만-라 로슈 아게Bispecific t cell activating antigen binding molecules
WO2016019969A1 (en)2014-08-082016-02-11Ludwig-Maximilians-Universität MünchenSubcutaneously administered bispecific antibodies for use in the treatment of cancer
GB201414823D0 (en)2014-08-202014-10-01Argen X BvMultispecific antibodies
EP3186281B1 (en)2014-08-282019-04-10Halozyme, Inc.Combination therapy with a hyaluronan-degrading enzyme and an immune checkpoint inhibitor
CN106687584B (en)2014-09-042021-08-13干细胞技术公司 Soluble antibody complexes for T cell or NK cell activation and expansion
MA40764A (en)2014-09-262017-08-01Chugai Pharmaceutical Co Ltd THERAPEUTIC AGENT INDUCING CYTOTOXICITY
US12116633B2 (en)2014-10-032024-10-15Oxford University Innovation LimitedAnalysis of T-cell monotypia
WO2016069283A1 (en)2014-10-312016-05-06The Trustees Of The University Of PennsylvaniaAltering gene expression in cart cells and uses thereof
AR102522A1 (en)2014-11-062017-03-08Hoffmann La Roche FC REGION VARIATIONS WITH MODIFIED PROPERTIES OF UNION TO FCRN AND PROTEIN A
CN107108720A (en)2014-11-062017-08-29豪夫迈·罗氏有限公司Fc region variants and its application method that FCRN with change is combined
EP3023437A1 (en)2014-11-202016-05-25EngMab AGBispecific antibodies against CD3epsilon and BCMA
MX381724B (en)2014-11-202025-03-13Hoffmann La Roche COMMON LIGHT CHAINS AND METHODS OF USE.
WO2016087514A1 (en)2014-12-022016-06-09Cemm - Forschungszentrum Für Molekulare Medizin GmbhAnti-mutant calreticulin antibodies and their use in the diagnosis and therapy of myeloid malignancies
JP6721590B2 (en)2014-12-032020-07-15エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Multispecific antibody
EP3029068A1 (en)2014-12-032016-06-08EngMab AGBispecific antibodies against CD3epsilon and BCMA for use in the treatment of diseases
AU2015357543B2 (en)2014-12-052021-10-21Eureka Therapeutics, Inc.Chimeric antigen receptors targeting Fc Receptor-like 5 and uses thereof
BR112017011914A2 (en)2014-12-052018-02-27Memorial Sloan-Kettering Cancer Center Antibody targeting b cell maturation antigen and methods of use?
AU2015357053B2 (en)2014-12-052021-10-07Merck Patent GmbhDomain-exchanged antibody
US9767555B2 (en)2015-01-052017-09-19Case Western Reserve UniversityDisease characterization from fused pathology and radiology data
PL3242890T3 (en)2015-01-082020-04-30BioNTech SEAgonistic tnf receptor binding agents
BR112017015136A2 (en)2015-01-142018-01-30Compass Therapeutics Llc multispecific immunomodulator antigen binding construct polypeptide, multispecific immunomodulator antigen binding construct, conjugate, pharmaceutical composition, method for treating an individual with cancer, method for inhibiting or reducing cancer growth, composition, cell, method of making a polypeptide of multispecific immunomodulatory antigen binding construct, vector or vector set and kit
US10689449B2 (en)2015-01-202020-06-23Igm Biosciences, Inc.Multimeric death domain-containing receptor-5 (DR5) antibodies and uses thereof
US20170151281A1 (en)2015-02-192017-06-01Batu Biologics, Inc.Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer
PT3268390T (en)2015-03-132025-01-13Novimmune SaMethods of purifying bispecific antibodies
TWI703157B (en)2015-04-132020-09-01美商輝瑞股份有限公司Cd3-specific antibodies, therapeutic bispecific antibodies and their uses
SI3283527T1 (en)2015-04-132021-04-30Five Prime Therapeutics, Inc. Combination therapy against cancer
WO2016176756A1 (en)2015-05-052016-11-10University Health NetworkNk cells and antibodies for cancer treatment
PL3611192T3 (en)2015-05-132025-07-07Ablynx N.V. T cell recruiting polypeptides based on TCR alpha/beta reactivity
EA201792662A1 (en)2015-06-012018-04-30Медиджин Иммьюнотерапиз Гмбх SPECIFIC ANTIBODIES TO T-CELL RECEPTOR
EA201792661A1 (en)2015-06-012018-05-31Медиджин Иммьюнотерапиз Гмбх METHOD OF OBTAINING ANTIBODIES AGAINST T-CELL RECEPTOR
EP3310814B1 (en)2015-06-162023-08-02F. Hoffmann-La Roche AGHumanized and affinity matured antibodies to fcrh5 and methods of use
DK3115376T3 (en)2015-07-102018-11-26Merus Nv HUMANT CD3 BINDING ANTIBODY
WO2017015623A2 (en)2015-07-232017-01-26Inhibrx LpMultivalent and multispecific gitr-binding fusion proteins
TW202346349A (en)2015-07-312023-12-01德商安美基研究(慕尼黑)公司Antibody constructs for dll3 and cd3
MX377710B (en)2015-08-032025-03-11Bristol Myers Squibb Co MONOCLONAL ANTIBODIES AGAINST BCMA.
WO2017031104A1 (en)2015-08-172017-02-23Janssen Pharmaceutica NvAnti-bcma antibodies, bispecific antigen binding molecules that bind bcma and cd3, and uses thereof
WO2017037634A1 (en)2015-08-312017-03-09National Research Council Of CanadaTgf-β-receptor ectodomain fusion molecules and uses thereof
US11747346B2 (en)2015-09-032023-09-05Novartis AgBiomarkers predictive of cytokine release syndrome
EP3356417A1 (en)2015-10-022018-08-08H. Hoffnabb-La Roche AgBispecific t cell activating antigen binding molecules binding mesothelin and cd3
BR112018006811A2 (en)2015-10-062018-10-16Univ Minnesota therapeutic compounds and methods
US11161915B2 (en)2015-10-082021-11-02Zymeworks Inc.Antigen-binding polypeptide constructs comprising kappa and lambda light chains and uses thereof
US11702477B2 (en)2015-11-062023-07-18Orionis Biosciences BVBi-functional chimeric proteins and uses thereof
EA039859B1 (en)2016-02-032022-03-21Эмджен Рисерч (Мюник) ГмбхBispecific antibody constructs binding egfrviii and cd3
CN109153728A (en)*2016-03-212019-01-04埃尔斯塔治疗公司 Multispecific and multifunctional molecules and their uses
WO2017167350A1 (en)2016-03-302017-10-05Horst LindhoferMultispecific antibodies for use in the treatment of a neoplasm of the urinary tract
WO2017180913A2 (en)2016-04-132017-10-19SanofiTrispecific and/or trivalent binding proteins
CA2937157A1 (en)2016-07-252018-01-25Ucl Business PlcProtein-based t-cell receptor knockdown
US11673971B2 (en)2016-09-232023-06-13Marengo Therapeutics, Inc.Multispecific antibody molecules comprising lambda and kappa light chains
EP3523331A1 (en)2016-10-072019-08-14Novartis AGChimeric antigen receptors for the treatment of cancer
JP7291396B2 (en)2016-11-222023-06-15ティーシーアール2 セラピューティクス インク. Compositions and methods for TCR reprogramming using fusion proteins
WO2018144777A2 (en)2017-02-012018-08-09Nant Holdings Ip, LlcCalreticulin-mediated cancer treatment
US20200291089A1 (en)2017-02-162020-09-17Elstar Therapeutics, Inc.Multifunctional molecules comprising a trimeric ligand and uses thereof
AU2018256406A1 (en)2017-04-192019-10-17Marengo Therapeutics, Inc.Multispecific molecules and uses thereof
WO2018193103A1 (en)2017-04-202018-10-25Adc Therapeutics SaCombination therapy with an anti-psma antibody-drug conjugate
WO2018201047A1 (en)2017-04-282018-11-01Elstar Therapeutics, Inc.Multispecific molecules comprising a non-immunoglobulin heterodimerization domain and uses thereof
BR112019024127A2 (en)2017-05-242020-06-23Pandion Therapeutics, Inc. TARGETED IMMUNOTOLERANCE
EP3630836A1 (en)2017-05-312020-04-08Elstar Therapeutics, Inc.Multispecific molecules that bind to myeloproliferative leukemia (mpl) protein and uses thereof
GB201709203D0 (en)2017-06-092017-07-26Autolus LtdAntigen-binding domain
WO2018237192A1 (en)2017-06-212018-12-27Gsbio, Llc BISPECIFIC ANTIBODIES HETERODIMERS
WO2019005641A1 (en)2017-06-252019-01-03Systimmune, Inc.Guidance and navigation control proteins and method of making and using thereof
WO2019010224A1 (en)2017-07-032019-01-10Torque Therapeutics, Inc.Fusion molecules targeting immune regulatory cells and uses thereof
US20200172868A1 (en)2017-07-192020-06-04Rubius Therapeutics, Inc.Compositions and methods related to multimodal therapeutic cell systems for infectious disease
AU2018312251B2 (en)2017-07-312025-02-20Trishula Therapeutics, Inc.Anti-CD39 antibodies, compositions comprising anti-CD39 antibodies and methods of using anti-CD39 antibodies
CN111183149A (en)2017-08-032020-05-19辛索克斯公司 Cytokine conjugates for the treatment of autoimmune diseases
WO2019035938A1 (en)2017-08-162019-02-21Elstar Therapeutics, Inc.Multispecific molecules that bind to bcma and uses thereof
US10578740B2 (en)2017-08-232020-03-03Mezmeriz Inc.Coherent optical distance measurement apparatus and method
KR20240138135A (en)2017-08-252024-09-20파이브 프라임 테라퓨틱스, 인크.B7-h4 antibodies and methods of use thereof
EA202090718A1 (en)2017-09-142020-07-01Драгонфлай Терапьютикс, Инк. PROTEINS BINDING NKG2D, CD16 AND LECTIN-LIKE C-TYPE MOLECULE-1 (CLL-1)
CN111629734A (en)2017-09-272020-09-04南加利福尼亚大学 Novel platforms for costimulation, novel CAR designs, and other enhancements for adoptive cell therapy
GB201718088D0 (en)2017-11-012017-12-13Autolus LtdVectors
MX2020005041A (en)2017-11-212020-10-12Univ Leland Stanford JuniorPartial agonists of interleukin-2.
EP3713959A1 (en)2017-11-212020-09-30Innate PharmaMultispecific antigen binding proteins
US20200377571A1 (en)2017-12-082020-12-03Elstar Therapeutics, Inc.Multispecific molecules and uses thereof
RU2694412C9 (en)2017-12-252019-09-18Федеральное государственное бюджетное образовательное учреждение высшего образования "Российский национальный исследовательский медицинский университет им. Н.И. Пирогова" Министерства здравоохранения Российской Федерации (ФГБОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России)Monoclonal antibodies and methods of using them
EP3733716A4 (en)2017-12-262021-11-24Nanjing GenScript Biotech Co., Ltd.Fusion protein dimer using antibody fc region as backbone and use thereof
TWI817974B (en)2017-12-282023-10-11日商中外製藥股份有限公司Cytotoxicity-inducing therapeutic agent
GB201800298D0 (en)2018-01-092018-02-21Autolus LtdMethod
WO2019139987A1 (en)2018-01-092019-07-18Elstar Therapeutics, Inc.Calreticulin binding constructs and engineered t cells for the treatment of diseases
EP3752178A1 (en)2018-02-162020-12-23Iltoo PharmaUse of interleukin 2 for treating sjögren's syndrome
WO2019178364A2 (en)2018-03-142019-09-19Elstar Therapeutics, Inc.Multifunctional molecules and uses thereof
EP3765517A1 (en)2018-03-142021-01-20Elstar Therapeutics, Inc.Multifunctional molecules that bind to calreticulin and uses thereof
KR20210005872A (en)2018-03-282021-01-15오리오니스 바이오사이언시즈 인코포레이티드 Bifunctional proteins and constructs thereof
TW202003580A (en)2018-05-212020-01-16美商坎伯斯治療有限責任公司Compositions and methods for enhancing the killing of target cells by NK cells
EA202091977A1 (en)2018-05-282021-02-09Драгонфлай Терапьютикс, Инк. MULTI-SPECIFIC BINDING PROTEINS THAT BIND CD33, NKG2D AND CD16 AND METHODS OF APPLICATION
EP3810640A1 (en)2018-06-252021-04-28University of WashingtonDe novo design of potent and selective interleukin mimetics
WO2020010250A2 (en)2018-07-032020-01-09Elstar Therapeutics, Inc.Anti-tcr antibody molecules and uses thereof
US20210277120A1 (en)2018-07-182021-09-09The General Hospital CorporationCompositions and methods for treatment of t cell malignancies
CN108949698B (en)2018-07-312019-05-31广东和信健康科技有限公司Hybridoma cell strain C11-6F7 and its HCMV monoclonal antibody and application of generation
GB201812650D0 (en)2018-08-032018-09-19Autolus LtdMolecular assessment of TRBC usage
UY38326A (en)2018-08-032020-01-31Amgen Inc ANTIBODY CONSTRUCTS FOR CLDN18.2 AND CD3
EA202091888A1 (en)2018-08-082020-10-23Драгонфлай Терапьютикс, Инк. VARIABLE ANTIBODY DOMAINS TARGETED ON THE NKG2D RECEPTOR
JP7512210B2 (en)2018-09-212024-07-08イノベント バイオロジックス (スウツォウ) カンパニー,リミテッド Novel interleukin 2 and uses thereof
CA3114038A1 (en)2018-09-252020-04-02Harpoon Therapeutics, Inc.Dll3 binding proteins and methods of use
CA3114179A1 (en)2018-09-282020-04-02Pierre Fabre MedicamentNew immunocytokines for the treatment of cancer
KR20210110563A (en)2018-10-182021-09-08킨드레드 바이오사이언시스, 인코포레이티드 FC variants with altered binding to the neonatal FC receptor (FCRN) for veterinary use
GB201817172D0 (en)2018-10-222018-12-05Autolus LtdAntibody
KR20210080460A (en)2018-10-232021-06-30드래곤플라이 쎄라퓨틱스, 인크. Heterodimeric Fc-fused protein
BR112021008204A2 (en)2018-10-292021-08-101Globe Biomedical Co., Ltd. new rationally designed protein compositions
GB201817822D0 (en)2018-10-312018-12-19Autolus LtdBinding domain
CN112912388A (en)2018-11-202021-06-04华盛顿大学Split interleukin mimetics and their uses
RU2712251C1 (en)2018-12-252020-01-27Федеральное государственное автономное образовательное учреждение высшего образования "Российский национальный исследовательский медицинский университет имени Н.И. Пирогова" Министерства здравоохранения Российской Федерации (ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России)Humanised anti-beta 9 chain antibodies of human trbv9 tkp family, and methods of using
AR117735A1 (en)2018-12-252021-08-25Joint Stock Company “Biocad” MONOCLONAL ANTIBODIES THAT SPECIFICALLY BIND TO REGION b OF THE HUMAN T-CELL RECEPTOR FAMILY TRBV-9, AND METHODS FOR ITS USE
WO2020142672A2 (en)2019-01-042020-07-09Elstar Therapeutics, Inc.Anti-tcr antibody molecules and uses thereof
US11235032B2 (en)2019-01-232022-02-01Massachusetts Institute Of TechnologyCombination immunotherapy dosing regimen for immune checkpoint blockade
SG11202109061YA (en)2019-02-212021-09-29Marengo Therapeutics IncMultifunctional molecules that bind to t cell related cancer cells and uses thereof
SG11202109056TA (en)2019-02-212021-09-29Marengo Therapeutics IncMultifunctional molecules that bind to calreticulin and uses thereof
WO2020172596A1 (en)2019-02-212020-08-27Elstar Therapeutics, Inc.Anti-tcr antibody molecules and thereof
AU2020224680B2 (en)2019-02-212025-06-19Marengo Therapeutics, Inc.Multifunctional molecules that bind to T cells and uses thereof to treat autoimmune disorders
SG11202108955QA (en)2019-02-212021-09-29Marengo Therapeutics IncAntibody molecules that bind to nkp30 and uses thereof
US11673953B2 (en)2019-03-012023-06-13Allogene Therapeutics, Inc.DLL3 targeting chimeric antigen receptors and binding agents
EP3937977A2 (en)2019-03-112022-01-19Janssen Biotech, Inc.Anti-v beta17 /anti-cd123 bispecific antibodies
WO2020249757A1 (en)2019-06-142020-12-17Philogen S.P.AImmunoconjugates comprising a single chain diabody and interleukin-15 or interleukin-15 and a sushi domain of interleukin-15 receptor alpha
KR20220097443A (en)2019-11-052022-07-07메르크 파텐트 게엠베하 Combination inhibition of PD-1, TGFβ and TIGIT for the treatment of cancer
AU2020384369B2 (en)2019-11-142025-02-13Marengo Therapeutics, Inc.Anti-TCR antibody molecules and uses thereof
CN116234829A (en)2020-01-032023-06-06马伦戈治疗公司anti-TCR antibody molecules and uses thereof
EP4084821A4 (en)2020-01-032024-04-24Marengo Therapeutics, Inc. CD33-BINDING MULTIFUNCTIONAL MOLECULES AND THEIR USES
JP2023510806A (en)2020-01-092023-03-15ビオミュネクス・ファーマシューティカルズ Multispecific antibodies that bind to both MAIT and tumor cells
EP4121518A4 (en)2020-03-162024-06-19Marengo Therapeutics, Inc. MANIPULATED CELL COMPOSITIONS AND METHODS OF USE THEREOF
AU2021261420A1 (en)2020-04-242022-12-01Marengo Therapeutics, Inc.Multifunctional molecules that bind to T cell related cancer cells and uses thereof
CN116917316A (en)2020-08-262023-10-20马伦戈治疗公司Antibody molecules that bind to NKp30 and uses thereof
CN116249718A (en)2020-08-262023-06-09马伦戈治疗公司Multifunctional molecules binding to calreticulin and uses thereof
KR20230074487A (en)2020-08-262023-05-30마렝고 테라퓨틱스, 인크. How to detect TRBC1 or TRBC2
EP4294527A1 (en)2021-02-172023-12-27GammaDelta Therapeutics LimitedAnti-tcr delta variable 1 antibodies
US20240150460A1 (en)*2021-02-262024-05-09Shenghe (China) Biopharmaceutical Co., Ltd.Anti-nkp30 antibody and application thereof
GB2623199A (en)2021-04-082024-04-10Marengo Therapeutics IncMultifunctional molecules binding to TCR and uses thereof
EP4337252A4 (en)2021-05-102025-04-23Amgen Inc.Dosing regimen for combination therapy targeting dll3 and pd-1
EP4426321A2 (en)2021-11-052024-09-11Marengo Therapeutics, Inc.Immune cell populations and uses thereof
CA3242160A1 (en)2021-12-222023-06-29Marengo Therapeutics, Inc.Multifuntional molecules binding to tcr and uses thereof
EP4466019A2 (en)2022-01-212024-11-27Marengo Therapeutics, Inc.Multifunctional molecules comprising g6b binder and/or cd34 binder and uses thereof
EP4601747A1 (en)2022-10-122025-08-20Marengo Therapeutics, Inc.Multifunctional molecules binding to tcr and uses thereof
AU2023361491A1 (en)2022-10-122025-05-08Marengo Therapeutics, Inc.Multifunctional molecules binding to tcr and uses thereof
WO2024197082A2 (en)2023-03-212024-09-26Marengo Therapeutics, Inc.Tcr targeting molecules and uses thereof
WO2024226532A2 (en)2023-04-242024-10-31Marengo Therapeutics, Inc.Multifunctional molecules binding to tcr and uses thereof
WO2024227109A1 (en)2023-04-272024-10-31Marengo Therapeutics, Inc.Combination therapies using molecules binding to tcr
WO2024254611A2 (en)2023-06-092024-12-12Marengo Therapeutics, Inc.Multispecific molecules binding to tcr and uses thereof

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