SG11202105441WA - Direct oligonucleotide synthesis on cells and biomolecules - Google Patents

Direct oligonucleotide synthesis on cells and biomolecules

Info

Publication number: SG11202105441WA
Authority: SG; Singapore
Prior art keywords: biomolecules; cells; oligonucleotide synthesis; direct oligonucleotide; direct
Prior art date: 2018-12-13

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2019-12-10Application filed by Dna ScriptfiledCriticalDna Script

2021-06-29Publication of SG11202105441WApublicationCriticalpatent/SG11202105441WA/en

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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1096—Processes for the isolation, preparation or purification of DNA or RNA cDNA Synthesis; Subtracted cDNA library construction, e.g. RT, RT-PCR
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B20/00—Methods specially adapted for identifying library members
- C40B20/04—Identifying library members by means of a tag, label, or other readable or detectable entity associated with the library members, e.g. decoding processes
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
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- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
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- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
- C40B50/16—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support involving encoding steps
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
- C40B50/18—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support using a particular method of attachment to the solid support
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/0054—Means for coding or tagging the apparatus or the reagents
- B01J2219/00547—Bar codes
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00722—Nucleotides
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/0074—Biological products
- B01J2219/00743—Cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/319—Chemical structure of the backbone linked by 2'-5' linkages, i.e. having a free 3'-position
- C—CHEMISTRY; METALLURGY
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
- C—CHEMISTRY; METALLURGY
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- C12N2330/00—Production
- C12N2330/30—Production chemically synthesised
- C12N2330/31—Libraries, arrays
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Q2521/00—Reaction characterised by the enzymatic activity
- C12Q2521/10—Nucleotidyl transfering
- C12Q2521/107—RNA dependent DNA polymerase,(i.e. reverse transcriptase)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Q2521/00—Reaction characterised by the enzymatic activity
- C12Q2521/10—Nucleotidyl transfering
- C12Q2521/131—Terminal transferase
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/117—Modifications characterised by incorporating modified base
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- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/179—Nucleic acid detection characterized by the use of physical, structural and functional properties the label being a nucleic acid

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Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Chemical Kinetics & Catalysis (AREA)
Microbiology (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Structural Engineering (AREA)
Analytical Chemistry (AREA)
Plant Pathology (AREA)
Immunology (AREA)
Crystallography & Structural Chemistry (AREA)
Bioinformatics & Computational Biology (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)

SG11202105441WA2018-12-132019-12-10Direct oligonucleotide synthesis on cells and biomoleculesSG11202105441WA (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP18306687		2018-12-13
EP19305219		2019-02-25
PCT/EP2019/084347WO2020120442A2 (en)	2018-12-13	2019-12-10	Direct oligonucleotide synthesis on cells and biomolecules

Publications (1)

Publication Number	Publication Date
SG11202105441WAtrue SG11202105441WA (en)	2021-06-29

Family

ID=68766789

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG11202105441WASG11202105441WA (en)	2018-12-13	2019-12-10	Direct oligonucleotide synthesis on cells and biomolecules

Country Status (10)

Country	Link
US (3)	US11268091B2 (en)
EP (2)	EP3894593B1 (en)
JP (1)	JP2022511931A (en)
KR (1)	KR20210104779A (en)
CN (1)	CN113423841A (en)
AU (1)	AU2019398307A1 (en)
CA (1)	CA3122494A1 (en)
IL (1)	IL283835A (en)
SG (1)	SG11202105441WA (en)
WO (1)	WO2020120442A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SG11202105441WA (en)	2018-12-13	2021-06-29	Dna Script	Direct oligonucleotide synthesis on cells and biomolecules
EP3924500A1 (en)*	2019-02-12	2021-12-22	DNA Script	Efficient product cleavage in template-free enzymatic synthesis of polynucleotides
US11365441B2 (en)	2019-05-22	2022-06-21	Mission Bio, Inc.	Method and apparatus for simultaneous targeted sequencing of DNA, RNA and protein
JP2022543568A (en)*	2019-08-01	2022-10-13	ディーエヌエースクリプト	Increased Yield of Long Sequences in Templateless Enzymatic Synthesis of Polynucleotides
CN115427559A (en)*	2020-04-20	2022-12-02	Dna斯克瑞普特公司	Terminal deoxynucleotidyl transferase variants and uses thereof
US20230313255A1 (en)	2020-07-15	2023-10-05	Dna Script	Massively Parallel Enzymatic Synthesis of Polynucleotides
AU2021347452A1 (en)	2020-09-22	2023-04-27	Dna Script	Stabilized n-terminally truncated terminal deoxynucleotidyl transferase variants and uses thereof
US12391970B2 (en)*	2020-11-11	2025-08-19	Microsoft Technology Licensing, Llc	Spatial control of polynucleotide synthesis by strand capping
EP4274907A4 (en)	2021-01-08	2025-01-15	Cellanome, Inc.	Devices and methods for analyzing biological samples
AU2022262794A1 (en)	2021-04-23	2023-11-02	Beth Israel Deaconess Medical Center, Inc.	Glycan modified nucleic acids, methods of preparation, and therapeutic uses
EP4352246A4 (en)*	2021-06-11	2025-06-25	Mission Bio, Inc.	Method, system and device for analyzing an analyte of a single cell
CN117616134A (en)*	2021-07-01	2024-02-27	美天施生物科技有限两合公司	UNIT-DNA composition for spatial barcoding and sequencing
CN116555216A (en)*	2022-01-28	2023-08-08	中国科学院天津工业生物技术研究所	Terminal transferase variant for controllable synthesis of single-stranded DNA and application
EP4555083A1 (en)*	2022-07-13	2025-05-21	DNA Script	Method of purifying solution comprising polynucleotide
CN120603956A (en)	2022-12-31	2025-09-05	Dna斯克瑞普特公司	Variable viscosity inks for inkjet delivery of enzymatic reagents
CN120418451A (en)	2023-01-06	2025-08-01	Dna斯克瑞普特公司	Method for obtaining correctly assembled nucleic acids
EP4530360A1 (en)	2023-09-29	2025-04-02	Miltenyi Biotec B.V. & Co. KG	Method for spatial barcoding
CN119662753A (en)*	2025-02-19	2025-03-21	天津中合基因科技有限公司	In-situ synthesis method of antibody coupled oligonucleotide enzymatic DNA

Family Cites Families (147)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4965188A (en)	1986-08-22	1990-10-23	Cetus Corporation	Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683202A (en)	1985-03-28	1987-07-28	Cetus Corporation	Process for amplifying nucleic acid sequences
US4683195A (en)	1986-01-30	1987-07-28	Cetus Corporation	Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4772691A (en)	1985-06-05	1988-09-20	The Medical College Of Wisconsin, Inc.	Chemically cleavable nucleotides
US4800159A (en)	1986-02-07	1989-01-24	Cetus Corporation	Process for amplifying, detecting, and/or cloning nucleic acid sequences
US4942124A (en)	1987-08-11	1990-07-17	President And Fellows Of Harvard College	Multiplex sequencing
US5047524A (en)	1988-12-21	1991-09-10	Applied Biosystems, Inc.	Automated system for polynucleotide synthesis and purification
US5262530A (en)	1988-12-21	1993-11-16	Applied Biosystems, Inc.	Automated system for polynucleotide synthesis and purification
CA2020958C (en)	1989-07-11	2005-01-11	Daniel L. Kacian	Nucleic acid sequence amplification methods
WO1991006678A1 (en)	1989-10-26	1991-05-16	Sri International	Dna sequencing
US5126022A (en)	1990-02-28	1992-06-30	Soane Tecnologies, Inc.	Method and device for moving molecules by the application of a plurality of electrical fields
US6054034A (en)	1990-02-28	2000-04-25	Aclara Biosciences, Inc.	Acrylic microchannels and their use in electrophoretic applications
US5210015A (en)	1990-08-06	1993-05-11	Hoffman-La Roche Inc.	Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
JP3080178B2 (en)	1991-02-18	2000-08-21	東洋紡績株式会社	Method for amplifying nucleic acid sequence and reagent kit therefor
US5665539A (en)	1991-07-12	1997-09-09	The Regents Of The University Of California	Immuno-polymerase chain reaction system for antigen detection
US5981179A (en)	1991-11-14	1999-11-09	Digene Diagnostics, Inc.	Continuous amplification reaction
US5498392A (en)	1992-05-01	1996-03-12	Trustees Of The University Of Pennsylvania	Mesoscale polynucleotide amplification device and method
US5587128A (en)	1992-05-01	1996-12-24	The Trustees Of The University Of Pennsylvania	Mesoscale polynucleotide amplification devices
US5436143A (en)	1992-12-23	1995-07-25	Hyman; Edward D.	Method for enzymatic synthesis of oligonucleotides
US5516664A (en)*	1992-12-23	1996-05-14	Hyman; Edward D.	Enzymatic synthesis of repeat regions of oligonucleotides
FR2703052B1 (en)	1993-03-26	1995-06-02	Pasteur Institut	New method of nucleic acid sequencing.
US5656745A (en)	1993-09-17	1997-08-12	Gilead Sciences, Inc.	Nucleotide analogs
WO1995018139A1 (en)	1993-12-30	1995-07-06	Chemgenes Corporation	Synthesis of propargyl modified nucleosides and phosphoramidites and their incorporation into defined sequence oligonucleotides
US6001229A (en)	1994-08-01	1999-12-14	Lockheed Martin Energy Systems, Inc.	Apparatus and method for performing microfluidic manipulations for chemical analysis
US5990300A (en)	1994-09-02	1999-11-23	Andrew C. Hiatt	Enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides
US5872244A (en)	1994-09-02	1999-02-16	Andrew C. Hiatt	3' protected nucleotides for enzyme catalyzed template-independent creation of phosphodiester bonds
US6214987B1 (en)	1994-09-02	2001-04-10	Andrew C. Hiatt	Compositions for enzyme catalyzed template-independent formation of phosphodiester bonds using protected nucleotides
US5763594A (en)	1994-09-02	1998-06-09	Andrew C. Hiatt	3' protected nucleotides for enzyme catalyzed template-independent creation of phosphodiester bonds
US5808045A (en)	1994-09-02	1998-09-15	Andrew C. Hiatt	Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides
US6232465B1 (en)	1994-09-02	2001-05-15	Andrew C. Hiatt	Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides
US5604097A (en)	1994-10-13	1997-02-18	Spectragen, Inc.	Methods for sorting polynucleotides using oligonucleotide tags
US5854033A (en)	1995-11-21	1998-12-29	Yale University	Rolling circle replication reporter systems
US6458530B1 (en)	1996-04-04	2002-10-01	Affymetrix Inc.	Selecting tag nucleic acids
US5917031A (en)	1996-04-19	1999-06-29	Taiko Pharmaceutical Co., Ltd.	Method of synthesizing polydeoxyribonucleotides
NZ333136A (en)	1996-06-04	2000-03-27	Univ Utah Res Found	Continuous monitoring of hybridization during PCR using fluorescence resonance energy transfer pairs
ZA975891B (en)	1996-07-05	1998-07-23	Combimatrix Corp	Electrochemical solid phase synthesis of polymers
US6074827A (en)	1996-07-30	2000-06-13	Aclara Biosciences, Inc.	Microfluidic method for nucleic acid purification and processing
US6482590B1 (en)*	1996-12-20	2002-11-19	Aventis Behring Gmbh	Method for polynucleotide amplification
ATE374815T1 (en)	1997-07-07	2007-10-15	Medical Res Council	METHOD OF INCREASE THE CONCENTRATION OF NUCLIC ACID MOLECULES
JP2001520377A (en)	1997-10-15	2001-10-30	アクレイラバイオサイエンシズ，インコーポレイティド	Laminated micro structural device and method of manufacturing laminated micro structural device
US6093302A (en)	1998-01-05	2000-07-25	Combimatrix Corporation	Electrochemical solid phase synthesis
US6251595B1 (en)	1998-06-18	2001-06-26	Agilent Technologies, Inc.	Methods and devices for carrying out chemical reactions
EP1961826A3 (en)	1999-03-10	2008-09-17	ASM Scientific, Inc.	A method for direct nucleic acid sequencing
GB9907813D0 (en)	1999-04-06	1999-06-02	Medical Biosystems Ltd	Synthesis
US7276336B1 (en)	1999-07-22	2007-10-02	Agilent Technologies, Inc.	Methods of fabricating an addressable array of biopolymer probes
US6323043B1 (en)	1999-04-30	2001-11-27	Agilent Technologies, Inc.	Fabricating biopolymer arrays
US6399952B1 (en)	1999-05-12	2002-06-04	Aclara Biosciences, Inc.	Multiplexed fluorescent detection in microfluidic devices
US6306599B1 (en)	1999-07-16	2001-10-23	Agilent Technologies Inc.	Biopolymer arrays and their fabrication
GB0013276D0 (en)	2000-06-01	2000-07-26	Amersham Pharm Biotech Uk Ltd	Nucleotide analogues
US6939451B2 (en)	2000-09-19	2005-09-06	Aclara Biosciences, Inc.	Microfluidic chip having integrated electrodes
AU2001296645A1 (en)	2000-10-06	2002-04-15	The Trustees Of Columbia University In The City Of New York	Massive parallel method for decoding dna and rna
EP1379692A4 (en)	2001-03-30	2005-08-31	Applera Corp	Nucleic acid analysis using non-templated nucleotide addition
AU2002307152A1 (en)	2001-04-06	2002-10-21	California Institute Of Technology	Nucleic acid amplification utilizing microfluidic devices
US7057026B2 (en)	2001-12-04	2006-06-06	Solexa Limited	Labelled nucleotides
GB0129012D0 (en)	2001-12-04	2002-01-23	Solexa Ltd	Labelled nucleotides
WO2003057010A2 (en)	2002-01-04	2003-07-17	Board Of Regents, The University Of Texas System	Droplet-based microfluidic oligonucleotide synthesis engine
DE10215035A1 (en)	2002-04-05	2003-10-23	Roche Diagnostics Gmbh	Recombinant terminal deoxynucleotide transferase with improved functionality
CA2491925A1 (en)	2002-07-08	2004-01-15	Shell Canada Limited	Choke for controlling the flow of drilling mud
ES2550513T3 (en)	2002-08-23	2015-11-10	Illumina Cambridge Limited	Modified nucleotides for polynucleotide sequencing
EP2365331B1 (en)	2002-11-14	2015-11-04	Valneva	Method to clone a single antigen-specfic lymphocyte.
US7932025B2 (en)	2002-12-10	2011-04-26	Massachusetts Institute Of Technology	Methods for high fidelity production of long nucleic acid molecules with error control
DE602004026033D1 (en)	2003-01-29	2010-04-29	454 Corp	SECONDARY SEQUENCING
JP2006513705A (en)	2003-02-05	2006-04-27	アマシャム・バイオサイエンス・コーポレイション	Nucleic acid growth
US7534561B2 (en)	2003-04-02	2009-05-19	Agilent Technologies, Inc.	Nucleic acid array in situ fabrication methods and arrays produced using the same
US7572581B2 (en)	2003-06-30	2009-08-11	Roche Molecular Systems, Inc.	2′-terminator nucleotide-related methods and systems
US7947817B2 (en)	2003-06-30	2011-05-24	Roche Molecular Systems, Inc.	Synthesis and compositions of 2'-terminator nucleotides
CA2531105C (en)	2003-07-05	2015-03-17	The Johns Hopkins University	Method and compositions for detection and enumeration of genetic variations
US20060102471A1 (en)	2004-11-18	2006-05-18	Karl Maurer	Electrode array device having an adsorbed porous reaction layer
US7393665B2 (en)	2005-02-10	2008-07-01	Population Genetics Technologies Ltd	Methods and compositions for tagging and identifying polynucleotides
US7407757B2 (en)	2005-02-10	2008-08-05	Population Genetics Technologies	Genetic analysis by sequence-specific sorting
US8212020B2 (en)	2005-03-11	2012-07-03	Steven Albert Benner	Reagents for reversibly terminating primer extension
US7544794B1 (en)	2005-03-11	2009-06-09	Steven Albert Benner	Method for sequencing DNA and RNA by synthesis
US20070034513A1 (en)	2005-03-25	2007-02-15	Combimatrix Corporation	Electrochemical deblocking solution for electrochemical oligomer synthesis on an electrode array
US20070020640A1 (en)	2005-07-21	2007-01-25	Mccloskey Megan L	Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis
WO2007087312A2 (en)	2006-01-23	2007-08-02	Population Genetics Technologies Ltd.	Molecular counting
ATE540750T1 (en)	2006-05-11	2012-01-15	Raindance Technologies Inc	MICROFLUIDIC DEVICE AND METHOD
WO2007147018A1 (en)	2006-06-14	2007-12-21	Cellpoint Diagnostics, Inc.	Analysis of rare cell-enriched samples
EP2024513B1 (en)	2006-06-14	2016-10-19	Verinata Health, Inc	Rare cell analysis using sample splitting and dna tags
WO2008042067A2 (en)	2006-09-28	2008-04-10	Illumina, Inc.	Compositions and methods for nucleotide sequencing
US8003312B2 (en)	2007-02-16	2011-08-23	The Board Of Trustees Of The Leland Stanford Junior University	Multiplex cellular assays using detectable cell barcodes
CA2691364C (en)	2007-06-19	2020-06-16	Stratos Genomics, Inc.	High throughput nucleic acid sequencing by expansion
WO2009015296A1 (en)	2007-07-24	2009-01-29	The Regents Of The University Of California	Microfabricated dropley generator
US9068181B2 (en)	2008-05-23	2015-06-30	The General Hospital Corporation	Microfluidic droplet encapsulation
CA2763790C (en)	2008-05-30	2016-11-22	Massachusetts Institute Of Technology	Compositions and methods for spatial separation and screening of cells
US9156010B2 (en)	2008-09-23	2015-10-13	Bio-Rad Laboratories, Inc.	Droplet-based assay system
GB2467704B (en)	2008-11-07	2011-08-24	Mlc Dx Inc	A method for determining a profile of recombined DNA sequences in T-cells and/or B-cells
ES2560209T3 (en)	2009-01-20	2016-02-17	The Board Of Trustees Of The Leland Stanford Junior University	Genetic expression in individual cells for the diagnosis, prognosis and identification of pharmacological targets
US8034923B1 (en)	2009-03-27	2011-10-11	Steven Albert Benner	Reagents for reversibly terminating primer extension
EP3842150A1 (en)	2009-10-27	2021-06-30	President and Fellows of Harvard College	Droplet creation techniques
US8674086B2 (en)	2010-06-25	2014-03-18	Intel Corporation	Nucleotides and oligonucleotides for nucleic acid sequencing
WO2012048341A1 (en)	2010-10-08	2012-04-12	President And Fellows Of Harvard College	High-throughput single cell barcoding
US10144950B2 (en)	2011-01-31	2018-12-04	Roche Sequencing Solutions, Inc.	Methods of identifying multiple epitopes in cells
GB201106254D0 (en)	2011-04-13	2011-05-25	Frisen Jonas	Method and product
US8841071B2 (en)	2011-06-02	2014-09-23	Raindance Technologies, Inc.	Sample multiplexing
US9896709B2 (en)	2012-03-13	2018-02-20	Swift Biosciences, Inc.	Methods and compositions for size-controlled homopolymer tailing of substrate polynucleotides by a nucleic acid polymerase
US9075041B2 (en)	2012-07-06	2015-07-07	Robert Bosch Gmbh	Methods for generating pH/ionic concentration gradient near electrode surfaces for modulating biomolecular interactions
US9910008B2 (en)	2012-07-06	2018-03-06	Robert Bosch Gmbh	Methods for generating pH/ionic concentration gradient near electrode surfaces for modulating biomolecular interactions
US9874538B2 (en)	2012-07-06	2018-01-23	Robert Bosch Gmbh	Methods for generating pH/ionic concentration gradient near electrode surfaces for modulating biomolecular interactions
SG11201500313YA (en)*	2012-07-24	2015-02-27	Sequenta Inc	Single cell analysis using sequence tags
WO2014060483A1 (en)	2012-10-17	2014-04-24	Spatial Transcriptomics Ab	Methods and product for optimising localised or spatial detection of gene expression in a tissue sample
WO2014108850A2 (en)	2013-01-09	2014-07-17	Yeda Research And Development Co. Ltd.	High throughput transcriptome analysis
WO2014144495A1 (en)	2013-03-15	2014-09-18	Abvitro, Inc.	Single cell bar-coding for antibody discovery
US8808989B1 (en)	2013-04-02	2014-08-19	Molecular Assemblies, Inc.	Methods and apparatus for synthesizing nucleic acids
US9279149B2 (en)	2013-04-02	2016-03-08	Molecular Assemblies, Inc.	Methods and apparatus for synthesizing nucleic acids
WO2014201273A1 (en)	2013-06-12	2014-12-18	The Broad Institute, Inc.	High-throughput rna-seq
WO2015058052A1 (en)	2013-10-18	2015-04-23	The Broad Institute Inc.	Spatial and cellular mapping of biomolecules in situ by high-throughput sequencing
EP2876166B1 (en)	2013-11-20	2016-12-14	Roche Diagnostics GmbH	New compound for sequencing by synthesis
FR3020071B1 (en)	2014-04-17	2017-12-22	Dna Script	PROCESS FOR THE SYNTHESIS OF NUCLEIC ACIDS, IN PARTICULAR LARGE NUCLEIC ACIDS, USE OF THE METHOD AND KIT FOR IMPLEMENTING THE METHOD
JP6853667B2 (en)	2014-04-21	2021-03-31	プレジデントアンドフェローズオブハーバードカレッジ	Systems and methods for barcoding nucleic acids
FR3025201B1 (en)*	2014-09-02	2018-10-12	Dna Script	MODIFIED NUCLEOTIDES FOR THE SYNTHESIS OF NUCLEIC ACIDS, A KIT COMPRISING SUCH NUCLEOTIDES AND THEIR USE FOR GENERATING SYNTHETIC NUCLEIC ACID GENES OR SEQUENCES
CN107873054B (en)	2014-09-09	2022-07-12	博德研究所	Droplet-based method and device for complex single-cell nucleic acid analysis
US20170298450A1 (en)*	2014-09-10	2017-10-19	The Regents Of The University Of California	Reconstruction of ancestral cells by enzymatic recording
US10059929B2 (en)*	2014-10-20	2018-08-28	Molecular Assemblies, Inc.	Modified template-independent enzymes for polydeoxynucleotide synthesis
US10900065B2 (en)*	2014-11-14	2021-01-26	University Of Washington	Methods and kits for labeling cellular molecules
CN107530654A (en)	2015-02-04	2018-01-02	加利福尼亚大学董事会	Sequence nucleic acids by barcoding in discrete entities
GB201502152D0 (en)*	2015-02-10	2015-03-25	Nuclera Nucleics Ltd	Novel use
GB201503534D0 (en)	2015-03-03	2015-04-15	Nuclera Nucleics Ltd	Novel method
AU2016248995B2 (en)	2015-04-17	2022-04-28	President And Fellows Of Harvard College	Barcoding systems and methods for gene sequencing and other applications
EP3283656A4 (en)*	2015-04-17	2018-12-05	Centrillion Technology Holdings Corporation	Methods for performing spatial profiling of biological molecules
KR20180030092A (en)	2015-07-13	2018-03-21	프레지던트 앤드 펠로우즈 오브 하바드 칼리지	How to store searchable information using nucleic acids
GB201512372D0 (en)	2015-07-15	2015-08-19	Nuclera Nucleics Ltd	Novel method
JP2017079634A (en)*	2015-10-27	2017-05-18	国立大学法人熊本大学	Method for detecting a target cell in a biological sample
US11092607B2 (en)	2015-10-28	2021-08-17	The Board Institute, Inc.	Multiplex analysis of single cell constituents
WO2017075292A1 (en)	2015-10-28	2017-05-04	The Broad Institute, Inc.	Systems and methods for determining relative abundances of biomolecules
WO2017164936A1 (en)	2016-03-21	2017-09-28	The Broad Institute, Inc.	Methods for determining spatial and temporal gene expression dynamics in single cells
FR3052462A1 (en)	2016-06-14	2017-12-15	Dna Script	POLYMERASE DNA VARIANTS OF THE POLX FAMILY
US11142791B2 (en)	2016-08-10	2021-10-12	The Regents Of The University Of California	Combined multiple-displacement amplification and PCR in an emulsion microdroplet
AU2017311306A1 (en)	2016-08-10	2019-03-14	President And Fellows Of Harvard College	Methods of de novo assembly of barcoded genomic DNA fragments
GB201701396D0 (en)	2017-01-27	2017-03-15	Nuclera Nucleics Ltd	Novel alternating-phase synthesis method
CA3052490C (en)	2017-03-13	2022-01-18	Gigagen, Inc.	Systems and methods for massively parallel combinatorial analysis of single cells
US11612873B2 (en)	2017-05-31	2023-03-28	Molecular Assemblies, Inc.	Homopolymer encoded nucleic acid memory
US11174512B2 (en)	2017-05-31	2021-11-16	Molecular Assemblies, Inc.	Homopolymer encoded nucleic acid memory
KR102583062B1 (en)	2017-05-31	2023-09-25	몰레큘러 어셈블리즈, 인크.	Homopolymer encoded nucleic acid memory
WO2018236889A2 (en)	2017-06-19	2018-12-27	Massachusetts Institute Of Technology	AUTOMATED PROCESSES FOR SYNTHESIZING AND MODIFYING PARALLELIZED AND EVOLUTIVE ENZYMA BIOPOLYMERS USING MICROFLUIDIC DEVICES
US20190078065A1 (en)	2017-09-08	2019-03-14	Sigma-Aldrich Co. Llc	Modified dna polymerases
JP2020535951A (en)	2017-09-29	2020-12-10	ザリージェンツオブザユニバーシティオブカリフォルニア	How to make a monodisperse emulsion
WO2019079802A1 (en)	2017-10-20	2019-04-25	President And Fellows Of Harvard College	Methods of encoding and high-throughput decoding of information stored in dna
WO2019084046A1 (en)	2017-10-23	2019-05-02	The Broad Institute, Inc.	Single cell cellular component enrichment from barcoded sequencing libraries
GB201718804D0 (en)	2017-11-14	2017-12-27	Nuclera Nucleics Ltd	Novel use
WO2019113506A1 (en)	2017-12-07	2019-06-13	The Broad Institute, Inc.	Methods and compositions for multiplexing single cell and single nuclei sequencing
CN112105725A (en)	2018-01-08	2020-12-18	Dna斯克瑞普特公司	Variants of terminal deoxynucleotidyl transferase and uses thereof
US11841371B2 (en)	2018-03-13	2023-12-12	The Broad Institute, Inc.	Proteomics and spatial patterning using antenna networks
EP3891303A4 (en)	2018-12-07	2022-09-14	Qiagen Sciences LLC	METHODS OF PREPARING DNA SAMPLES FOR RNA SEQUENCING AND CDNA SAMPLES AND THEIR USES
WO2020123319A2 (en)	2018-12-10	2020-06-18	10X Genomics, Inc.	Methods of using master / copy arrays for spatial detection
SG11202105441WA (en)	2018-12-13	2021-06-29	Dna Script	Direct oligonucleotide synthesis on cells and biomolecules
US20220119871A1 (en)	2019-01-28	2022-04-21	The Broad Institute, Inc.	In-situ spatial transcriptomics
US11634766B2 (en)	2019-02-04	2023-04-25	The Broad Institute, Inc.	Methods and compositions for analyzing nucleic acids

2019
- 2019-12-10SGSG11202105441WApatent/SG11202105441WA/enunknown
- 2019-12-10JPJP2021533202Apatent/JP2022511931A/enactivePending
- 2019-12-10CNCN201980091982.0Apatent/CN113423841A/enactivePending
- 2019-12-10AUAU2019398307Apatent/AU2019398307A1/ennot_activeAbandoned
- 2019-12-10USUS16/970,590patent/US11268091B2/enactiveActive
- 2019-12-10EPEP19813589.9Apatent/EP3894593B1/enactiveActive
- 2019-12-10EPEP24203665.5Apatent/EP4464778A3/enactivePending
- 2019-12-10KRKR1020217021817Apatent/KR20210104779A/ennot_activeWithdrawn
- 2019-12-10CACA3122494Apatent/CA3122494A1/enactivePending
- 2019-12-10WOPCT/EP2019/084347patent/WO2020120442A2/ennot_activeCeased
2021
- 2021-03-04USUS17/192,578patent/US11993773B2/enactiveActive
- 2021-06-09ILIL283835Apatent/IL283835A/enunknown
2022
- 2022-03-04USUS17/687,128patent/US20220186213A1/ennot_activeAbandoned

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US11268091B2 (en)	2022-03-08
US20210009994A1 (en)	2021-01-14
US20210198661A1 (en)	2021-07-01
WO2020120442A3 (en)	2020-07-23
EP4464778A3 (en)	2025-02-19
US20220186213A1 (en)	2022-06-16
EP3894593B1 (en)	2024-10-02
IL283835A (en)	2021-07-29
KR20210104779A (en)	2021-08-25
EP3894593A2 (en)	2021-10-20
AU2019398307A1 (en)	2021-06-10
CA3122494A1 (en)	2020-06-18
US11993773B2 (en)	2024-05-28
WO2020120442A2 (en)	2020-06-18
JP2022511931A (en)	2022-02-01
EP4464778A2 (en)	2024-11-20
CN113423841A (en)	2021-09-21

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