Movatterモバイル変換


[0]ホーム

URL:


SG11202101455TA - Methods and compositions for adoptive t cell therapy incorporating induced notch signaling - Google Patents

Methods and compositions for adoptive t cell therapy incorporating induced notch signaling

Info

Publication number
SG11202101455TA
SG11202101455TASG11202101455TASG11202101455TASG11202101455TASG 11202101455T ASG11202101455T ASG 11202101455TASG 11202101455T ASG11202101455T ASG 11202101455TASG 11202101455T ASG11202101455T ASG 11202101455TASG 11202101455T ASG11202101455T ASG 11202101455TA
Authority
SG
Singapore
Prior art keywords
adoptive
compositions
methods
cell therapy
notch signaling
Prior art date
Application number
SG11202101455TA
Inventor
Stanley Riddell
Irwin Bernstein
Margot Pont
Original Assignee
Hutchinson Fred Cancer Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hutchinson Fred Cancer ResfiledCriticalHutchinson Fred Cancer Res
Publication of SG11202101455TApublicationCriticalpatent/SG11202101455TA/en

Links

Classifications

Landscapes

SG11202101455TA2018-08-282019-08-28Methods and compositions for adoptive t cell therapy incorporating induced notch signalingSG11202101455TA (en)

Applications Claiming Priority (2)

Application NumberPriority DateFiling DateTitle
US201862723936P2018-08-282018-08-28
PCT/US2019/048574WO2020047099A1 (en)2018-08-282019-08-28Methods and compositions for adoptive t cell therapy incorporating induced notch signaling

Publications (1)

Publication NumberPublication Date
SG11202101455TAtrue SG11202101455TA (en)2021-03-30

Family

ID=67982131

Family Applications (1)

Application NumberTitlePriority DateFiling Date
SG11202101455TASG11202101455TA (en)2018-08-282019-08-28Methods and compositions for adoptive t cell therapy incorporating induced notch signaling

Country Status (9)

CountryLink
US (1)US20210292711A1 (en)
EP (1)EP3844266A1 (en)
JP (1)JP2021534785A (en)
CN (1)CN112930393A (en)
AU (1)AU2019329984A1 (en)
BR (1)BR112021003830A2 (en)
CA (1)CA3110089A1 (en)
SG (1)SG11202101455TA (en)
WO (1)WO2020047099A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
WO2021007573A1 (en)*2019-07-112021-01-14H. Lee Moffitt Cancer Center And Research Institute, Inc.Engineering notch ligands to enhance the anti-tumor activity of adoptively transferred t cells
WO2022165367A1 (en)*2021-01-292022-08-04Fred Hutchinson Cancer Research CenterMethods and compositions for enhancing cd4+ phenotype for adoptive t cell therapy
CN113832102B (en)*2021-09-272024-03-12苏州东岭生物技术有限公司CD3/CD28/DLL4 magnetic beads, and preparation method and application thereof
CN116716349B (en)*2023-08-012023-10-31江苏集萃药康生物科技股份有限公司Construction method and application of DLL4 humanized mouse model

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
CA136551A (en)1911-08-031911-10-31Hedwig HeeronRolling mill
US4690915A (en)1985-08-081987-09-01The United States Of America As Represented By The Department Of Health And Human ServicesAdoptive immunotherapy as a treatment modality in humans
IE20030749A1 (en)1991-05-032003-11-12Indiana University FoundationHuman notch and delta binding domains in torporythmic proteins, and methods based thereon
US5420032A (en)1991-12-231995-05-30Universitge LavalHoming endonuclease which originates from chlamydomonas eugametos and recognizes and cleaves a 15, 17 or 19 degenerate double stranded nucleotide sequence
US5792632A (en)1992-05-051998-08-11Institut PasteurNucleotide sequence encoding the enzyme I-SceI and the uses thereof
US5780300A (en)1995-09-291998-07-14Yale UniversityManipulation of non-terminally differentiated cells using the notch pathway
US6451995B1 (en)1996-03-202002-09-17Sloan-Kettering Institute For Cancer ResearchSingle chain FV polynucleotide or peptide constructs of anti-ganglioside GD2 antibodies, cells expressing same and related methods
RO120850B1 (en)*1996-11-072006-08-30Imperial College Of Science Technology & MedicNotch
EP1109921A4 (en)1998-09-042002-08-28Sloan Kettering Inst Cancer FOR PROSTATE-SPECIFIC MEMBRANE-ANTI-SPECIFIC FUSION RECEPTORS AND THEIR USE
AU2001265346A1 (en)2000-06-022001-12-17Memorial Sloan-Kettering Cancer CenterArtificial antigen presenting cells and methods of use thereof
US6984522B2 (en)2000-08-032006-01-10Regents Of The University Of MichiganIsolation and use of solid tumor stem cells
US6689744B2 (en)2000-09-222004-02-10Genentech, Inc.Notch receptor agonists and uses
US20030119771A1 (en)2001-08-222003-06-26Rompaey Luc VanModulators of bone homeostasis identified in a high-throughput screen
JP2003093048A (en)*2001-09-262003-04-02Asahi Kasei CorpCulture medium for producing new cellular preparation
US20030170238A1 (en)2002-03-072003-09-11Gruenberg Micheal L.Re-activated T-cells for adoptive immunotherapy
ES2292994T3 (en)2002-03-152008-03-16Cellectis SIMPLE HYBRID AND CHAIN MEGANUCLEASES AND ITS USE.
WO2003087159A2 (en)*2002-04-052003-10-23Lorantis LimitedModulators of the notch signalling pathway and uses thereof in medical treatment
US7446190B2 (en)2002-05-282008-11-04Sloan-Kettering Institute For Cancer ResearchNucleic acids encoding chimeric T cell receptors
WO2004032969A1 (en)*2002-10-092004-04-22Lorantis LimitedModulation of immune function
WO2004064863A1 (en)*2003-01-232004-08-05Lorantis LimitedTreatment of autoimmune diseases using an activator for the notch signaling pathway
CA2514517A1 (en)2003-01-282004-08-12CellectisUse of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof
WO2006056061A1 (en)*2004-11-242006-06-01Val-Chum, S.E.C.Methods to identify, prepare, and use naive t cell recent thymic emigrants
WO2007027226A2 (en)*2005-04-282007-03-08Board Of Regents, The University Of Texas SystemSystems and methods for the production of differentiated cells
EP1945762B1 (en)2005-10-182013-05-01Precision BiosciencesRationally-designed meganucleases with altered sequence specificity and dna-binding affinity
JP5478254B2 (en)2006-10-192014-04-23ジェネンテック, インコーポレイテッド Anti-Notch3 agonist antibodies and their use in the treatment of Notch3-related diseases
CL2007002989A1 (en)2006-10-192008-05-16Genentech Inc ANTI-NOTCH3 ANTIBODIES; NUCLEIC ACID CODING THEM; VECTOR AND CELL THAT UNDERSTANDS IT; METHOD OF PRODUCTION; AND ITS USE FOR THE DIAGNOSIS OF DISEASES RELATED TO NOTCH3.
EP2115128A2 (en)*2007-01-302009-11-11Deutsches Rheuma-Forschungszentrum BerlinMethod for modulating the immune response by activating or inactivating the notch and/or stat4 signal path
CA2682527C (en)2007-03-302017-07-11Memorial Sloan-Kettering Cancer CenterConstitutive expression of costimulatory ligands on adoptively transferred t lymphocytes
EP2356270B1 (en)2008-11-072016-08-24Fabrus LlcCombinatorial antibody libraries and uses thereof
WO2010059543A1 (en)2008-11-202010-05-27Merck Sharp & Dohme Corp.Generation and characterization of anti-notch antibodies for therapeutic and diagnostic use
WO2010141249A2 (en)2009-06-022010-12-09Merck Sharp & Dohme Corp.Generation, characterization and uses thereof of anti-notch3 antibodies
JP6208580B2 (en)2010-05-172017-10-04サンガモ セラピューティクス, インコーポレイテッド Novel DNA binding protein and use thereof
PH12013501201A1 (en)2010-12-092013-07-29Univ PennsylvaniaUse of chimeric antigen receptor-modified t cells to treat cancer
WO2013126726A1 (en)2012-02-222013-08-29The Trustees Of The University Of PennsylvaniaDouble transgenic t cells comprising a car and a tcr and their methods of use
SG10201701800YA (en)2012-05-252017-04-27Univ CaliforniaMethods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription
US10316289B2 (en)*2012-09-062019-06-11The United States Of America, As Represented By The Secretary, Department Of Health And Human ServicesMethods of producing T memory stem cell populations
PL2784162T3 (en)2012-12-122016-01-29Broad Inst IncEngineering of systems, methods and optimized guide compositions for sequence manipulation
US8697359B1 (en)2012-12-122014-04-15The Broad Institute, Inc.CRISPR-Cas systems and methods for altering expression of gene products
US10696946B2 (en)*2013-02-222020-06-30The Board Of Trustees Of The University Of IllinoisT-REG cell expansion
US9683039B2 (en)2013-03-142017-06-20New York UniversityNotch agonists for the treatment of cancer
EP3760719A1 (en)2013-11-182021-01-06CRISPR Therapeutics AGCrispr-cas system materials and methods
AU2015264120A1 (en)2014-05-222016-11-24Board Of Regents Of The University Of Texas SystemLILRB2 and notch-mediated expansion of hematopoietic precursor cells
EP3152301B1 (en)2014-06-042021-05-05Fred Hutchinson Cancer Research CenterExpansion and engraftment of stem cells using notch 1 and/or notch 2 agonists
MX389823B (en)*2014-10-272025-03-20Fred Hutchinson Cancer Center COMPOSITIONS AND METHODS TO ENHANCE THE EFFICACY OF ADOPTIVE CELLULAR IMMUNOTHERAPY.
JP7061961B2 (en)*2015-10-202022-05-02フジフィルム セルラー ダイナミクス,インコーポレイテッド How to induce the differentiation of pluripotent stem cells into immune cells
MA45488A (en)*2015-10-222018-08-29Juno Therapeutics Gmbh CELL CULTURE PROCESSES, KITS AND APPARATUS
CA3003145A1 (en)*2015-10-302017-05-04Gay M. CrooksMethods of generating t-cells from stem cells and immunotherapeutic methods using the t-cells
JP7049261B2 (en)*2016-04-082022-04-06ザ ガバニング カウンシル オブ ザ ユニバーシティ オブ トロント Methods for Producing T Progenitor Cells from Stem Cells and / or Progenitor Cells and Use of the T Progenitor Cells
US11261250B2 (en)2016-07-222022-03-01Fred Hutchinson Cancer Research CenterBi-specific molecule for cell-specific Notch inhibition and related methods and compositions

Also Published As

Publication numberPublication date
AU2019329984A1 (en)2021-03-11
US20210292711A1 (en)2021-09-23
WO2020047099A1 (en)2020-03-05
JP2021534785A (en)2021-12-16
BR112021003830A2 (en)2021-07-20
EP3844266A1 (en)2021-07-07
CA3110089A1 (en)2020-03-05
CN112930393A (en)2021-06-08

Similar Documents

PublicationPublication DateTitle
IL277079A (en)Cartyrin compositions and methods for use
SG11202104017VA (en)Tyk2 inhibitors and uses thereof
IL280134A (en)Anti-cd112r compositions and methods
ZA201903327B (en)Compositions and methods for the induction of cd8+ t¿cells
IL282447A (en)Methods and compositions for ocular cell therapy
TW201613966A (en)SynTac polypeptides and uses thereof
SG11202105502RA (en)Methods for treatment using adoptive cell therapy
IL283409A (en)Tyk2 inhibitors and uses thereof
IL282090A (en)Tyk2 inhibitors and uses thereof
SG10202104804PA (en)Methods and compositions for dosing in adoptive cell therapy
SG11202101455TA (en)Methods and compositions for adoptive t cell therapy incorporating induced notch signaling
SG11202101996QA (en)Improved therapeutic t cell
IL275075A (en)Phenotypic markers for cell therapy and related methods
EP3645708A4 (en)Compositions and methods for adoptive cell therapy for cancer
IL271022A (en)Compositions and methods for providing cell replacement therapy
IL271256A (en)Compositions and methods for treating tauopathies
IL255816B (en)Synergistic combination of neuronal viability factors and uses thereof
IL259486A (en)Agents for the treatment of diseases associated with undesired cell proliferation
IL273452A (en)Cell compositions comprising antigen-specific t cells for adoptive therapy
SG11202104448WA (en)Compositions and methods
IL263218A (en)Composition and methods for microbiota therapy
ZA201902781B (en)Compositions and methods for the treatment of xerostomia
IL282160A (en)Compositions and methods for transfecting cells
GB201817444D0 (en)Methods and compositions
GB201819987D0 (en)Methods and compositions

[8]ページ先頭

©2009-2025 Movatter.jp