| WO1992007615A1 (en) | 1990-10-29 | 1992-05-14 | Regents Of The University Of Minnesota | A bioartificial liver |
| US5523226A (en) | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
| US6372482B1 (en) | 1997-01-16 | 2002-04-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Device and method for performing a biological modification of a fluid |
| US5912227A (en) | 1995-01-27 | 1999-06-15 | North Carolina State University | Method of enhancing nutrient uptake |
| WO1998021312A1 (en) | 1996-11-08 | 1998-05-22 | Rpms Technology Limited | Human hepatocytes in three-dimensional support systems |
| EP1063289A1 (en) | 1998-03-03 | 2000-12-27 | JMS Co., Ltd. | Liver cell clones for artifical liver and extracorporeal liver assist device |
| IL138201A0 (en) | 1998-03-02 | 2001-10-31 | Univ Massachusetts | Embryonic or stem-like cell lines produced by cross-species nuclear transplantation |
| US7291626B1 (en) | 1998-04-09 | 2007-11-06 | John Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
| US6542858B1 (en) | 1998-09-14 | 2003-04-01 | Lion Bioscience Ag | Pharmacokinetic-based drug design tool and method |
| US7759113B2 (en) | 1999-04-30 | 2010-07-20 | The General Hospital Corporation | Fabrication of tissue lamina using microfabricated two-dimensional molds |
| JP3725147B2 (en) | 1999-08-25 | 2005-12-07 | 東洋紡績株式会社 | Cell culture module having a vascular network-like structure |
| US6607501B2 (en) | 2001-05-14 | 2003-08-19 | Reynolds G. Gorsuch | Process and apparatus for utilization of in vivo extracted plasma with tissue engineering devices, bioreactors, artificial organs, and cell therapy applications |
| US20030129751A1 (en) | 2001-05-16 | 2003-07-10 | Grikscheit Tracy C. | Tissue-engineered organs |
| JP2005510232A (en) | 2001-11-26 | 2005-04-21 | アドバンスド セル テクノロジー、インク. | Production and use of reprogrammed human somatic cell nuclei and autologous and syngeneic human stem cells |
| EP2264146A1 (en) | 2001-12-07 | 2010-12-22 | Geron Corporation | Islet cells from human embryonic stem cells |
| US20050170506A1 (en) | 2002-01-16 | 2005-08-04 | Primegen Biotech Llc | Therapeutic reprogramming, hybrid stem cells and maturation |
| US20030187515A1 (en) | 2002-03-26 | 2003-10-02 | Hariri Robert J. | Collagen biofabric and methods of preparing and using the collagen biofabric |
| US7160719B2 (en) | 2002-06-07 | 2007-01-09 | Mayo Foundation For Medical Education And Research | Bioartificial liver system |
| JP4187167B2 (en) | 2002-08-28 | 2008-11-26 | 和守 船津 | Modified cross-section hollow fiber membrane cell-containing device |
| TW571101B (en) | 2003-01-21 | 2004-01-11 | Ind Tech Res Inst | Fluid analysis apparatus |
| WO2004071573A2 (en) | 2003-02-07 | 2004-08-26 | The Johns Hopkins University | Hypoxia induced mitogenic factor |
| CA2515717A1 (en) | 2003-02-10 | 2004-08-19 | Banyu Pharmaceutical Co., Ltd. | Melanin-concentrating hormone receptor antagonists containing piperidine derivatives as the active ingredient |
| DE10362002B4 (en) | 2003-06-23 | 2006-10-12 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Adult pluripotent stem cells |
| WO2007059007A2 (en) | 2005-11-14 | 2007-05-24 | Cythera, Inc. | Markers of definitive endoderm |
| US8647873B2 (en) | 2004-04-27 | 2014-02-11 | Viacyte, Inc. | PDX1 expressing endoderm |
| US20050266554A1 (en) | 2004-04-27 | 2005-12-01 | D Amour Kevin A | PDX1 expressing endoderm |
| US7625753B2 (en) | 2003-12-23 | 2009-12-01 | Cythera, Inc. | Expansion of definitive endoderm cells |
| US7541185B2 (en) | 2003-12-23 | 2009-06-02 | Cythera, Inc. | Methods for identifying factors for differentiating definitive endoderm |
| NZ547920A (en) | 2003-12-23 | 2009-06-26 | Cythera Inc | Definitive endoderm |
| US7985585B2 (en) | 2004-07-09 | 2011-07-26 | Viacyte, Inc. | Preprimitive streak and mesendoderm cells |
| US8241905B2 (en) | 2004-02-24 | 2012-08-14 | The Curators Of The University Of Missouri | Self-assembling cell aggregates and methods of making engineered tissue using the same |
| DE102004017476B4 (en) | 2004-04-08 | 2009-03-26 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Process for the preparation of a cell composition containing epithelial cells |
| EA011953B1 (en) | 2004-04-27 | 2009-06-30 | Китера, Инк. | Pdx1 expressing endoderm |
| JP4650608B2 (en) | 2004-05-18 | 2011-03-16 | 信越化学工業株式会社 | Photomask blank and photomask manufacturing method |
| EP1747264B1 (en) | 2004-05-21 | 2012-09-12 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Multicellular tissue and organ culture systems |
| EP1773871B1 (en) | 2004-06-17 | 2014-10-15 | Thrasos Innovation, Inc. | Tdf-related compounds and analogs thereof |
| CN102925406B (en) | 2004-07-09 | 2019-11-22 | 维亚希特公司 | Method for identifying factors for differentiating definitive endoderm |
| EP1791553B1 (en) | 2004-07-12 | 2013-10-23 | Emisphere Technologies, Inc. | Compositions for delivering peptide yy and pyy agonists |
| MX2007000728A (en) | 2004-07-21 | 2007-03-15 | Ambrx Inc | Biosynthetic polypeptides utilizing non-naturally encoded amino acids. |
| JP5102030B2 (en) | 2004-08-13 | 2012-12-19 | ユニバーシティ・オブ・ジョージア・リサーチ・ファウンデイション・インコーポレイテッド | Compositions and methods for self-renewal and differentiation in human embryonic stem cells |
| US20060236415A1 (en) | 2005-03-09 | 2006-10-19 | Silversides David W | Neural crest cells specific promoters; isolated neural crest cells; and methods of isolating and of using same |
| US7604929B2 (en) | 2005-04-21 | 2009-10-20 | In Vitro Technologies, Inc. | Cellular compositions and methods for their preparation |
| US8435787B2 (en) | 2005-05-10 | 2013-05-07 | Rutgers, The State University Of New Jersey | Alginate polyelectrolyte encapsulation of embryonic stem cells |
| WO2006126219A1 (en) | 2005-05-26 | 2006-11-30 | Fresenius Medical Care Deutschland G.M.B.H. | Liver progenitor cells |
| GB0517382D0 (en) | 2005-08-26 | 2005-10-05 | Plasticell Ltd | Cell culture |
| US7776592B2 (en) | 2005-08-31 | 2010-08-17 | Stc.Unm | Human renal stem cells |
| US20070122905A1 (en) | 2005-10-27 | 2007-05-31 | D Amour Kevin A | PDX1-expressing dorsal and ventral foregut endoderm |
| EP1960530A4 (en) | 2005-11-29 | 2013-12-25 | Spencer Rosero | System and method for supporting a biological chip device |
| US20070239083A1 (en) | 2006-01-18 | 2007-10-11 | Axel Voss | Shock wave generators |
| US20070238169A1 (en) | 2006-04-11 | 2007-10-11 | The Board Of Trustees Of The Leland Stanford Junior University | Cell sorter and culture system |
| US8685730B2 (en)* | 2006-05-02 | 2014-04-01 | Wisconsin Alumni Research Foundation | Methods and devices for differentiating pluripotent stem cells into cells of the pancreatic lineage |
| WO2007136707A2 (en) | 2006-05-17 | 2007-11-29 | University Of Utah Research Foundation | Methods and compositions related to eosinophil regulation |
| SI2040713T1 (en) | 2006-06-27 | 2014-11-28 | Intercept Pharmaceuticals, Inc. | Bile acid derivatives as fxr ligands for the prevention or treatment of fxr-mediated deseases or conditions |
| CA2658768C (en) | 2006-07-21 | 2016-05-17 | Massachusetts Institute Of Technology | End-modified poly(beta-amino esters) and uses thereof |
| US8497240B2 (en) | 2006-08-17 | 2013-07-30 | Amylin Pharmaceuticals, Llc | DPP-IV resistant GIP hybrid polypeptides with selectable properties |
| WO2008073273A2 (en) | 2006-12-08 | 2008-06-19 | E. I. Du Pont De Nemours And Company | Water-based coating composition |
| US20090137544A1 (en) | 2006-12-08 | 2009-05-28 | Yin-Xiong Li | Formation and rejuvenation of organs and alcohol damaged organ regeneration through stem cell nutrients |
| EP2120546B1 (en) | 2006-12-18 | 2016-09-28 | Ben Gurion University Of The Negev | Scaffolding for tissue regeneration or repair |
| US7722560B2 (en) | 2007-02-09 | 2010-05-25 | The Regents Of The University Of Michigan | Mechanical extension implants for short bowel syndrome |
| US8512697B2 (en) | 2007-05-16 | 2013-08-20 | The University Of North Carolina At Chapel Hill | Delivery of micro- and nanoparticles with blood platelets |
| FR2917425B1 (en) | 2007-06-18 | 2010-11-19 | Univ Nancy 1 Henri Poincare | METHOD FOR THE PROLIFERATION OF CELLS ON POLYELECTROLYTE MULTILAYERS AND ITS APPLICATION, IN PARTICULAR TO THE PREPARATION OF CELLULARIZED BIOMATERIALS |
| GB2467645B (en) | 2007-07-06 | 2011-12-21 | Univ London | A method of proliferating human hepatocyte cells |
| EP2022848A1 (en) | 2007-08-10 | 2009-02-11 | Hubrecht Institut | A method for identifying, expanding, and removing adult stem cells and cancer stem cells |
| WO2009033011A1 (en) | 2007-09-07 | 2009-03-12 | Children's Hospital Medical Center | Use of secretor, lewis and sialyl antigen levels as predictors for disease |
| US7695963B2 (en) | 2007-09-24 | 2010-04-13 | Cythera, Inc. | Methods for increasing definitive endoderm production |
| WO2009076529A1 (en) | 2007-12-11 | 2009-06-18 | Research Development Foundation | Small molecules for neuronal differentiation of embryonic stem cells |
| EP2235162B1 (en) | 2008-01-08 | 2014-10-15 | The University Of Queensland | Method of producing a population of cells |
| EP2318031A4 (en) | 2008-06-03 | 2012-09-12 | Aethlon Medical Inc | Enhanced antiviral therapy methods and devices |
| SG193829A1 (en) | 2008-06-04 | 2013-10-30 | Tissuse Gmbh | Organ-on-a-chip-device |
| EP2310847B1 (en) | 2008-06-24 | 2016-05-04 | The Curators Of The University Of Missouri | Self-assembling multicellular bodies and methods of producing a three-dimensional biological structure using the same |
| ITRM20080342A1 (en) | 2008-06-26 | 2009-12-27 | Univ Degli Studi Udine | DOLLS-SIMILAR PULP CELLS, INSULATION AND USE METHODS. |
| US20130115673A1 (en) | 2008-07-16 | 2013-05-09 | Biotime, Inc. | Methods of Screening Embryonic Progenitor Cell Lines |
| WO2011009106A2 (en) | 2009-07-16 | 2011-01-20 | Biotime, Inc. | Methods and compositions for in vitro and in vivo chondrogenesis |
| US20110305672A1 (en) | 2008-07-25 | 2011-12-15 | University Of Georgia Research Foundation, Inc. | COMPOSITIONS FOR MESODERM DERIVED ISL1+ MULTIPOTENT CELLS (IMPs), EPICARDIAL PROGENITOR CELLS (EPCs) AND MULTIPOTENT CD56C CELLS (C56Cs) AND METHODS OF PRODUCING AND USING SAME |
| US20110300543A1 (en) | 2008-10-31 | 2011-12-08 | The Trustees Of Columbia University In The City Of New York | Methods for making induced pluripotent stem cells from mesenchymal stem cells |
| US8895300B2 (en) | 2008-11-04 | 2014-11-25 | Viacyte, Inc. | Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof |
| EP2352512A1 (en) | 2008-11-05 | 2011-08-10 | Merck Sharp & Dohme Corp. | Mechanism of neuromedin u action and uses thereof |
| CN102307990A (en) | 2008-12-03 | 2012-01-04 | 国际干细胞公司 | Methods of deriving differentiated cells from stem cells |
| JP5351601B2 (en) | 2008-12-26 | 2013-11-27 | 矢崎総業株式会社 | Insulating cap manufacturing method and insulating cap manufacturing apparatus |
| GB201111244D0 (en) | 2011-06-30 | 2011-08-17 | Konink Nl Akademie Van Wetenschappen Knaw | Culture media for stem cells |
| WO2010090513A2 (en) | 2009-02-03 | 2010-08-12 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising said stem cells. |
| US9752124B2 (en) | 2009-02-03 | 2017-09-05 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising the stem cells |
| EP2412800A1 (en) | 2010-07-29 | 2012-02-01 | Koninklijke Nederlandse Akademie van Wetenschappen | Liver organoid, uses thereof and culture method for obtaining them |
| WO2010094694A1 (en) | 2009-02-23 | 2010-08-26 | F. Hoffmann-La Roche Ag | Assays to predict cardiotoxicity |
| WO2010105204A2 (en) | 2009-03-13 | 2010-09-16 | Mayo Foundation For Medical Education And Research | Bioartificial liver |
| CN102361642A (en) | 2009-03-17 | 2012-02-22 | 爱克森医药公司 | Method of treating nonalcoholic steatohepatitis with elevated doses of ursodeoxycholic acid |
| WO2010127399A1 (en) | 2009-05-06 | 2010-11-11 | Walter And Eliza Hall Institute Of Medical Research | Gene expression profiles and uses thereof |
| US9446076B2 (en) | 2009-05-20 | 2016-09-20 | Cardio3 Biosciences S.A. | Pharmaceutical composition for the treatment of heart diseases |
| CN102596989A (en) | 2009-05-29 | 2012-07-18 | 诺沃-诺迪斯克有限公司 | Induced derivation of specific endoderm from hps cell-derived definitive endoderm |
| WO2010143747A1 (en) | 2009-06-10 | 2010-12-16 | 公立大学法人奈良県立医科大学 | Method for production of artificial intestinal tract |
| CN102459574B (en) | 2009-06-18 | 2016-06-29 | 塞拉提斯股份公司 | Growth and the 3D culture systems of differentiation for dry (hPS) cell of people's pluripotency |
| EP2724739B1 (en) | 2009-07-30 | 2015-07-01 | Tandem Diabetes Care, Inc. | Portable infusion pump system |
| US8501476B2 (en) | 2009-10-07 | 2013-08-06 | Brown University | Assays and methods for fusing cell aggregates to form proto-tissues |
| WO2011047040A2 (en) | 2009-10-13 | 2011-04-21 | University Of Louisville Research Foundation, Inc. | Methods and compositions to support transplanted tissue integration and innosculation with adipose stromal cells |
| GB0918564D0 (en) | 2009-10-22 | 2009-12-09 | Plasticell Ltd | Nested cell encapsulation |
| CN101696396A (en) | 2009-10-27 | 2010-04-21 | 中国人民解放军军事医学科学院卫生学环境医学研究所 | Construction method and use of model of hepatitis B virus infection in vivo |
| US9724410B2 (en) | 2009-11-24 | 2017-08-08 | Alderbio Holdings Llc | Anti-IL-6 antibodies or fragments thereof to treat or inhibit cachexia, associated with chemotherapy toxicity |
| EP2504424A1 (en) | 2009-11-25 | 2012-10-03 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Method for hepatic differentiation of definitive endoderm cells |
| WO2011079018A2 (en) | 2009-12-23 | 2011-06-30 | Centocor Ortho Biotech Inc. | Differentiation of human embryonic stem cells |
| US20110231942A1 (en) | 2010-03-17 | 2011-09-22 | Xi He | Tiki1 and tiki2, wnt inhibitors |
| US9394522B2 (en) | 2010-03-22 | 2016-07-19 | Takara Bio Europe Ab | Directed differentiation and maturation of pluripotent cells into hepatocyte like cells by modulation of Wnt-signalling pathway |
| CN102906248A (en) | 2010-03-25 | 2013-01-30 | 国际干细胞公司 | Method of altering differentiative state of cell and compositions thereof |
| EP2380920A1 (en) | 2010-04-22 | 2011-10-26 | QGel SA | Hydrogel precursor formulation and production process thereof |
| EP2563908B1 (en) | 2010-04-25 | 2019-01-09 | Icahn School of Medicine at Mount Sinai | Generation of anterior foregut endoderm from pluripotent cells |
| WO2011140441A2 (en) | 2010-05-06 | 2011-11-10 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| AU2011267849B2 (en) | 2010-06-15 | 2015-02-05 | FUJIFILM Cellular Dynamics, Inc. | Generation of induced pluripotent stem cells from small volumes of peripheral blood |
| CA2804595C (en) | 2010-07-07 | 2018-11-13 | Cellular Dynamics International, Inc. | Endothelial cell production by programming |
| US8609406B2 (en) | 2010-08-24 | 2013-12-17 | Regents Of The University Of Minnesota | Non-static suspension culture of cell aggregates |
| CA2809305C (en) | 2010-08-31 | 2019-06-11 | Janssen Biotech, Inc. | Differentiation of pluripotent stem cells |
| CN109536438A (en) | 2010-11-15 | 2019-03-29 | 艾克塞利瑞提德生物技术公司 | Neural stem cell is generated by mankind's cytotrophoblast stem cells |
| WO2012089669A1 (en) | 2010-12-31 | 2012-07-05 | Universität Für Bodenkultur Wien | Method of generating induced pluripotent stem cells and differentiated cells |
| US8951781B2 (en) | 2011-01-10 | 2015-02-10 | Illumina, Inc. | Systems, methods, and apparatuses to image a sample for biological or chemical analysis |
| US9200258B2 (en) | 2011-01-27 | 2015-12-01 | University Of Maryland, Baltimore | Multicellular organotypic model of human intestinal mucosa |
| EP2484750A1 (en) | 2011-02-07 | 2012-08-08 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Monitoring system for cell culture |
| CA2828110C (en) | 2011-02-28 | 2020-03-31 | President And Fellows Of Harvard College | Cell culture system |
| JP6196163B2 (en) | 2011-03-17 | 2017-09-13 | ミネルバ バイオテクノロジーズ コーポレーション | Methods for producing pluripotent stem cells |
| GB201106395D0 (en) | 2011-04-14 | 2011-06-01 | Hubrecht Inst | Compounds |
| WO2012154834A1 (en) | 2011-05-09 | 2012-11-15 | President And Fellows Of Harvard College | Aerosol delivery to a microfluidic device |
| WO2012155110A1 (en) | 2011-05-11 | 2012-11-15 | Massachusetts Institute Of Technology | Microgels and microtissues for use in tissue engineering |
| US20120291096A1 (en) | 2011-05-12 | 2012-11-15 | Nokia Corporation | Method and apparatus for secure signing and utilization of distributed computations |
| SG10201805199RA (en) | 2011-06-02 | 2018-07-30 | Harvard College | Methods and Uses for Ex Vivo Tissue Culture Systems |
| CA2840192A1 (en) | 2011-06-23 | 2012-12-27 | The Children's Hospital Of Philadelphia | Self-renewing endodermal progenitor lines generated from human pluripotent stem cells and methods of use thereof |
| WO2013040087A2 (en) | 2011-09-12 | 2013-03-21 | Organovo, Inc. | Platform for engineered implantable tissues and organs and methods of making the same |
| JP2013066414A (en) | 2011-09-22 | 2013-04-18 | National Institute Of Advanced Industrial Science & Technology | Surface marker of stomach precursor cell |
| WO2014066811A1 (en) | 2012-10-25 | 2014-05-01 | The Johns Hopkins University | Bioreducible poly (b-amino ester)s for sirna delivery |
| JP6238445B2 (en) | 2011-10-27 | 2017-11-29 | 国立大学法人 東京医科歯科大学 | Colorectal epithelial stem cell isolation and culture technology, and colorectal epithelial transplantation technology using this |
| WO2013063588A1 (en) | 2011-10-28 | 2013-05-02 | The Board Of Trustees Of The Leland Stanford Junior University | Ex vivo culture, proliferation and expansion of primary tissue organoids |
| EP2773955B1 (en) | 2011-11-04 | 2018-07-18 | inRegen | Drug screening and potency assays |
| ES2656150T3 (en) | 2011-11-14 | 2018-02-23 | Universitätsklinikum Jena | Diagnosis of sepsis and systemic inflammatory response syndrome |
| AU2012347534B2 (en) | 2011-12-08 | 2018-01-25 | Fred Hutchinson Cancer Research Center | Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells |
| US10087422B2 (en) | 2011-12-09 | 2018-10-02 | President And Fellows Of Harvard College | Organ chips and uses thereof |
| WO2013086486A1 (en) | 2011-12-09 | 2013-06-13 | President And Fellows Of Harvard College | Integrated human organ-on-chip microphysiological systems |
| EP3045912B1 (en) | 2011-12-19 | 2018-09-19 | UMC Utrecht Holding B.V. | A rapid quantitative assay to measure cftr function in a primary intestinal culture model |
| JP2015510391A (en) | 2011-12-23 | 2015-04-09 | アントフロゲネシス コーポレーション | Organoids containing decellularized and reconstructed placental vascular scaffolds |
| US9828583B2 (en) | 2012-01-13 | 2017-11-28 | The General Hospital Corporation | Isolated human lung progenitor cells and uses thereof |
| KR101886114B1 (en) | 2012-01-31 | 2018-08-07 | 웨이크 포리스트 유니버시티 헬스 사이언시즈 | Innervation of engineered structures |
| WO2013126813A1 (en) | 2012-02-22 | 2013-08-29 | Amgen Inc. | Autologous mammalian models derived from induced pluripotent stem cells and related methods |
| EP2634251A1 (en) | 2012-02-29 | 2013-09-04 | Technische Universität Berlin | 3D in vitro bi-phasic cartilage-bone construct |
| CA2869972A1 (en) | 2012-04-09 | 2013-10-17 | Thomas J. Goodwin | Alternating ionic magnetic resonance (aimr) multiple-chambered culture apparatus and methods of use |
| CA2868392A1 (en) | 2012-05-23 | 2013-11-28 | Estelle DOUDEMENT | Compositions and methods of obtaining and using endoderm and hepatocyte cells |
| FI3597749T3 (en) | 2012-05-25 | 2023-10-09 | Univ California | METHODS AND COMPOSITIONS FOR RNA-DIRECTED MODIFICATION OF TARGET DNA AND RNA-DIRECTED MODULATION OF TRANSCRIPTION |
| EP3957714A1 (en) | 2012-06-08 | 2022-02-23 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into pancreatic endocrine cells |
| US20140099709A1 (en) | 2012-06-19 | 2014-04-10 | Organovo, Inc. | Engineered three-dimensional connective tissue constructs and methods of making the same |
| DK3336097T3 (en) | 2012-06-19 | 2020-09-28 | Intercept Pharmaceuticals Inc | Preparation of non-crystalline obeticholic acid |
| DE102012105540A1 (en) | 2012-06-26 | 2014-04-24 | Karlsruher Institut für Technologie | Vascular model, process for its preparation and its use |
| EP2875360B1 (en) | 2012-07-20 | 2018-08-08 | Agency For Science, Technology And Research | In vitro assay for predicting renal proximal tubular cell toxicity |
| WO2014018691A1 (en) | 2012-07-24 | 2014-01-30 | The Trustees Of Columbia University In The City Of New York | Generation of airway and lung progenitors and epithelial cells and three-dimensional anterior foregut spheres |
| GB201216796D0 (en) | 2012-09-20 | 2012-11-07 | Cambridge Entpr Ltd | In vitro pancreatic differentiation |
| DK2712918T3 (en) | 2012-09-28 | 2015-02-16 | Tissuse Gmbh | Multi-organ-chip with improved lifetime and homeostasis |
| EP2716298A1 (en) | 2012-10-03 | 2014-04-09 | Institut Pasteur | A nod2-dependant pathway of cytoprotection of stem cells |
| JP6494515B2 (en) | 2012-10-19 | 2019-04-03 | エージェンシー フォー サイエンス, テクノロジー アンド リサーチ | Method for differentiating stem cells into one or more cell lineages |
| WO2014082096A1 (en) | 2012-11-26 | 2014-05-30 | The Trustees Of Columbia University In The City Of New York | Method for culture of human and mouse prostate organoids and uses thereof |
| PL2735326T3 (en) | 2012-11-26 | 2017-08-31 | Gambro Lundia Ab | Liver support system |
| CN105143445B (en) | 2012-11-29 | 2020-07-07 | 宝生物欧洲公司 | Maturation of hepatocyte-like cells derived from human pluripotent stem cells |
| WO2014093655A2 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains |
| JP2016505256A (en) | 2012-12-12 | 2016-02-25 | ザ・ブロード・インスティテュート・インコーポレイテッ | CRISPR-Cas component system, method and composition for sequence manipulation |
| IL293526A (en) | 2012-12-12 | 2022-08-01 | Harvard College | Providing, engineering and optimizing systems, methods and compositions for sequence manipulation and therapeutic applications |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| EP4279588A3 (en) | 2012-12-12 | 2024-01-17 | The Broad Institute, Inc. | Engineering of systems, methods and optimized guide compositions for sequence manipulation |
| EP2743345A1 (en) | 2012-12-13 | 2014-06-18 | IMBA-Institut für Molekulare Biotechnologie GmbH | Three dimensional heterogeneously differentiated tissue culture |
| KR20150103203A (en) | 2012-12-31 | 2015-09-09 | 얀센 바이오테크 인코포레이티드 | Suspension and clustering of human pluripotent cells for differentiation into pancreatic endocrine cells |
| US20150359849A1 (en) | 2013-01-31 | 2015-12-17 | President And Fellows Of Harvard College | Methods of increasing neuronal connectivity and/or treating a neurodegenerative condition |
| US10913933B2 (en) | 2013-02-13 | 2021-02-09 | Wake Forest University Health Sciences | Bioengineered liver constructs and methods relating thereto |
| GB201304245D0 (en) | 2013-03-08 | 2013-04-24 | Inst Quimic De Sarria | Chemical compounds |
| WO2014165056A1 (en) | 2013-03-12 | 2014-10-09 | Board Of Regents, The University Of Texas System | High throughput mechanical strain generating system for cell cultures and applications thereof |
| HUE043785T2 (en) | 2013-03-13 | 2019-09-30 | Wisconsin Alumni Res Found | Methods and materials for hematoendothelial differentiation of human pluripotent stem cells under defined conditions |
| AU2014236150B2 (en) | 2013-03-14 | 2019-10-31 | The Regents Of The University Of California | In vitro production of medial ganglionic eminence precursor cells |
| CN108865972B (en) | 2013-03-14 | 2022-07-29 | 布里格海姆妇女医院公司 | a cell culture solution |
| WO2014152906A2 (en) | 2013-03-14 | 2014-09-25 | Research Institute At Nationwide Children's Hospital, Inc. | Tissue engineered intestine |
| US8859286B2 (en) | 2013-03-14 | 2014-10-14 | Viacyte, Inc. | In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells |
| US9442105B2 (en) | 2013-03-15 | 2016-09-13 | Organovo, Inc. | Engineered liver tissues, arrays thereof, and methods of making the same |
| US20160237400A1 (en) | 2013-03-15 | 2016-08-18 | The Jackson Laboratory | Isolation of non-embryonic stem cells and uses thereof |
| WO2014153294A1 (en) | 2013-03-17 | 2014-09-25 | The Regents Of The University Of California | Method to expand and transduce cultured human small and large intestinal stem cells |
| US9677085B2 (en) | 2013-03-18 | 2017-06-13 | Massachusetts Institute Of Technology | Engineering a heterogeneous tissue from pluripotent stem cells |
| WO2014148646A1 (en) | 2013-03-21 | 2014-09-25 | 国立大学法人京都大学 | Pluripotent stem cell for neuronal differentiation induction |
| EP2796873A1 (en) | 2013-04-25 | 2014-10-29 | QGel SA | Method for a cell-based drug screening assay and the use thereof |
| US20160245653A1 (en) | 2013-04-30 | 2016-08-25 | Sangtae Park | Cylindrical resonator gyroscope |
| KR102757386B1 (en) | 2013-05-08 | 2025-01-21 | 인리젠 | Organoids comprising isolated renal cells and uses thereof |
| US10545133B2 (en) | 2013-05-13 | 2020-01-28 | The Johns Hopkins University | Molecular signatures of invasive cancer subpopulations |
| US10954489B2 (en) | 2013-06-04 | 2021-03-23 | The Regents Of The University Of California | Liver-mimetic device and method for simulation of hepatic function using such device |
| JP6253265B2 (en) | 2013-06-05 | 2017-12-27 | 学校法人関西医科大学 | Method for isolating esophageal epithelial stem cells |
| US11060065B2 (en) | 2013-06-10 | 2021-07-13 | Corning Incorporated | Tissue structure and preparation method thereof |
| KR102375753B1 (en) | 2013-06-14 | 2022-03-18 | 더 유니버서티 어브 퀸슬랜드 | Renal progenitor cells |
| JP6738729B2 (en) | 2013-06-17 | 2020-08-12 | ザ・ブロード・インスティテュート・インコーポレイテッド | Delivery, engineering and optimization of systems, methods and compositions for targeting and modeling postmitotic cell diseases and disorders |
| KR20160056869A (en) | 2013-06-17 | 2016-05-20 | 더 브로드 인스티튜트, 인코퍼레이티드 | Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using viral components |
| JP6455934B2 (en) | 2013-07-23 | 2019-01-23 | 公立大学法人横浜市立大学 | Method for imparting vasculature to biological tissue |
| KR20160042039A (en) | 2013-08-09 | 2016-04-18 | 알데릭스, 인코포레이티드 | Compounds and methods for inhibiting phosphate transport |
| CA2922247C (en) | 2013-08-28 | 2023-03-07 | Promethera Biosciences S.A./N.V. | Method for producing adult liver progenitor cells |
| GB201317869D0 (en) | 2013-10-09 | 2013-11-20 | Cambridge Entpr Ltd | In vitro production of foregut stem cells |
| CN105849252B (en) | 2013-10-25 | 2020-03-17 | 新加坡科技研究局 | Culturing pluripotent stem cells |
| WO2015071474A2 (en) | 2013-11-18 | 2015-05-21 | Crispr Therapeutics Ag | Crispr-cas system materials and methods |
| JP2016539117A (en) | 2013-11-22 | 2016-12-15 | セレクティスCellectis | Method for generating a batch of allogeneic T cells with averaged potency |
| AU2014353973B2 (en) | 2013-11-22 | 2021-01-28 | Riken | Method for manufacturing telencephalon or progenitor tissue thereof |
| EP2876441B1 (en) | 2013-11-26 | 2017-10-25 | Bergen Teknologioverforing AS | Quantitative analysis of contact-depending cell-to-cell transfer and disease transmission |
| CA2944220C (en) | 2013-12-20 | 2024-01-02 | President And Fellows Of Harvard College | Organomimetic devices and methods of use and manufacturing thereof |
| US9568897B2 (en) | 2014-01-02 | 2017-02-14 | General Electric Company | Controller system for variable parameter and related program product |
| EP3094720B1 (en) | 2014-01-14 | 2021-07-21 | Yale University | Compositions and methods of preparing airway cells |
| US11648335B2 (en) | 2014-01-31 | 2023-05-16 | Wake Forest University Health Sciences | Organ/tissue decellularization, framework maintenance and recellularization |
| AU2015217406A1 (en) | 2014-02-11 | 2016-08-25 | Celularity Inc. | Micro-organoids, and methods of making and using the same |
| US10369254B2 (en) | 2014-02-26 | 2019-08-06 | The Regents Of The University Of California | Method and apparatus for in vitro kidney organogenesis |
| SG10202107992XA (en) | 2014-02-27 | 2021-09-29 | Public Univ Corp Yokohama City Univ | Method for generating cell condensate for self-organization |
| DE102014003465A1 (en) | 2014-03-11 | 2015-09-17 | NeuroProof GmbH | Obtaining brain region-specific neuronal cultures from three-dimensional tissue cultures of stem cells |
| EP3119879B1 (en) | 2014-03-19 | 2019-12-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A method for inducing human cholangiocyte differentiation |
| MA39748A (en) | 2014-03-21 | 2021-04-21 | Tobira Therapeutics Inc | CENICRIVIROC FOR THE TREATMENT OF FIBROSIS |
| EP3126490B1 (en) | 2014-04-04 | 2020-09-30 | Organovo, Inc. | Engineered three-dimensional breast tissue, adipose tissue, and tumor disease model |
| WO2015156929A1 (en) | 2014-04-07 | 2015-10-15 | The Trustees Of Columbia University In The City Of New York | Method for culture of human bladder cell lines and organoids and uses thereof |
| US10222370B2 (en) | 2014-04-07 | 2019-03-05 | Rush University Medical Center | Screening assay for choice of prebiotic to prevent/treat gastrointestinal and systemic diseases |
| JP6865038B2 (en) | 2014-04-11 | 2021-04-28 | サイマベイ・セラピューティクス・インコーポレイテッドCymaBay Therapeutics,Inc. | Treatment of NAFLD and NASH |
| WO2015168022A1 (en) | 2014-04-27 | 2015-11-05 | The Research Foundation For The State University Of New York | Enamel products and methods of use |
| WO2015173425A1 (en) | 2014-05-16 | 2015-11-19 | Koninklijke Nederlandse Akademie Van Wetenschappen | Improved culture method for organoids |
| SG11201609953XA (en) | 2014-05-28 | 2016-12-29 | Childrens Hosp Medical Center | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| WO2015184375A2 (en) | 2014-05-29 | 2015-12-03 | Whitehead Institute For Biomedical Research | Compositions and methods for promoting intestinal stem cell and/or non-stem progenitor cell function |
| US10683476B2 (en) | 2014-05-29 | 2020-06-16 | Icahn School Of Medicine At Mount Sinai | Method and apparatus to prepare cardiac organoids in a bioreactor system |
| EP3152295B1 (en) | 2014-06-05 | 2020-07-29 | Cedars-Sinai Medical Center | A novel and efficient method for reprogramming immortalized lymphoblastoid cell lines to induced pluripotent stem cells |
| CA2950470A1 (en) | 2014-06-06 | 2015-12-10 | Vrije Universiteit Brussel | Human hepatic 3d co-culture model and uses thereof |
| FR3022110B1 (en) | 2014-06-13 | 2016-07-01 | Liphatech Inc | RODONTICIDE APPAT AND METHOD FOR CONTROLLING HARMFUL TARGET RODENTS USING SUCH APPAT |
| US10028503B2 (en) | 2014-06-18 | 2018-07-24 | Children's Hospital Medical Center | Platelet storage methods and compositions for same |
| JP2017524377A (en) | 2014-06-20 | 2017-08-31 | ラトガース,ザ ステート ユニバーシティ オブ ニュー ジャージー | Single cell-derived organoid |
| EP3160503B1 (en) | 2014-06-26 | 2021-02-17 | The Trustees of Columbia University in the City of New York | Inhibition of serotonin expression in gut enteroendocrine cells results in conversion to insulin-positive cells |
| AU2015289464A1 (en) | 2014-07-17 | 2017-02-02 | Celmatix Inc. | Methods and systems for assessing infertility and related pathologies |
| KR20230134598A (en) | 2014-07-29 | 2023-09-21 | 센젠 하이타이드 바이오파마슈티컬 리미티드 | Berberine salts, ursodeoxycholic salts and combinations, methods of preparation and application thereof |
| US12247224B2 (en) | 2014-07-30 | 2025-03-11 | Senthil Muthuswamy | Organoids for drug screening and personalized medicine |
| CN107075472A (en) | 2014-08-22 | 2017-08-18 | 剑桥企业有限公司 | Resetting pluripotent stem cells |
| CN106795489B (en) | 2014-08-28 | 2021-07-06 | 信铭普罗米迪拉亚洲有限公司 | Methods for the production of adult liver progenitor cells |
| CA2955254A1 (en) | 2014-08-29 | 2016-03-03 | Immunomedics, Inc. | Identification of cancer genes by in-vivo fusion of human cancer cells and animal cells |
| KR20170066418A (en) | 2014-09-12 | 2017-06-14 | 토비라 쎄라퓨틱스, 인크. | Cenicriviroc combination therapy for the treatment of fibrosis |
| JP2017529877A (en) | 2014-10-06 | 2017-10-12 | オルガノボ インコーポレイテッド | Artificial kidney tissue, array thereof, and production method thereof |
| CN107075471A (en) | 2014-10-08 | 2017-08-18 | 新加坡科技研究局 | Stem cell is divided into the method for hepatocyte lineage |
| WO2016061071A1 (en) | 2014-10-14 | 2016-04-21 | Cellular Dynamics International, Inc. | Generation of keratinocytes from pluripotent stem cells and mantenance of keratinocyte cultures |
| JP6804438B2 (en) | 2014-10-17 | 2020-12-23 | チルドレンズ ホスピタル メディカル センター | An in vivo model of the human small intestine using pluripotent stem cells, and methods for making and using it. |
| US20160121023A1 (en) | 2014-10-30 | 2016-05-05 | Massachusetts Institute Of Technology | Materials and Methods for Rescue of Ischemic Tissue and Regeneration of Tissue Integrity During Resection, Engraftment and Transplantation |
| US10479977B2 (en) | 2014-11-07 | 2019-11-19 | The Trustees Of Columbia University In The City Of New York | Osteochondroreticular stem cells for bone and cartilage regeneration |
| CN104387451B (en) | 2014-11-07 | 2020-12-18 | 浙江海洋学院 | A kind of clam enzymolysis oligopeptide with repairing effect on non-alcoholic fatty liver disease cell model and preparation method thereof |
| WO2016081742A1 (en) | 2014-11-19 | 2016-05-26 | The Trustees Of Columbia University In The City Of New York | Systems, methods, and devices for cell cycle synchronization of stem cells |
| CA2968655C (en) | 2014-11-25 | 2021-11-16 | President And Fellows Of Harvard College | Methods for generation of podocytes from pluripotent stem cells and cells produced by the same |
| US20170260501A1 (en) | 2014-11-25 | 2017-09-14 | International Stem Cell Corporation | Derivation of neural crest stem cells and uses thereof |
| AU2015353521B2 (en) | 2014-11-26 | 2021-11-04 | Accelerated Biosciences Corp. | Induced hepatocytes and uses thereof |
| GB201421094D0 (en) | 2014-11-27 | 2015-01-14 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium |
| GB201421092D0 (en) | 2014-11-27 | 2015-01-14 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium |
| AU2014277667B2 (en) | 2014-12-15 | 2022-07-14 | The University Of Queensland | Differentiation of pluripotent stem cells to form renal organoids |
| DK3237597T3 (en) | 2014-12-22 | 2021-03-15 | Ecole Polytechnique Fed Lausanne Epfl | FACILITIES FOR HIGH FLOW AGGREGATION AND MANIPULATION OF MAMMAL CELLS |
| WO2016103269A1 (en) | 2014-12-23 | 2016-06-30 | Ramot At Tel-Aviv University Ltd. | Populations of neural progenitor cells and methods of producing and using same |
| BR112017014341A2 (en) | 2015-01-09 | 2018-03-27 | Gilead Apollo, Llc | method and system for treating, stabilizing, or reducing the severity or progression of a nonalcoholic fatty liver disease, and, composition. |
| WO2016115326A1 (en) | 2015-01-15 | 2016-07-21 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for modulating genome editing |
| EP3252144A4 (en) | 2015-01-28 | 2018-08-08 | Public University Corporation Yokohama City University | Method for preparing bone marrow cell aggregate |
| US20160256672A1 (en) | 2015-02-10 | 2016-09-08 | Cedars-Sinai Medical Center | Induced pluripotent stem cell-derived hepatocyte based bioartificial liver device |
| CN105985395A (en) | 2015-02-13 | 2016-10-05 | 江苏奥赛康药业股份有限公司 | Obeticholic acid compound, and medicinal composition containing compound |
| WO2016140716A1 (en) | 2015-03-02 | 2016-09-09 | The Trustees Of Columbia University In The City Of New York | Injectable microtissue systems, devices, and methods |
| US10787640B2 (en) | 2015-03-03 | 2020-09-29 | The Board Of Trustees Of The Leland Stanford Junior University | Producing mesodermal cell types and methods of using the same |
| AU2016226178B2 (en) | 2015-03-03 | 2021-07-29 | President And Fellows Of Harvard College | Methods of generating functional human tissue |
| US9965139B2 (en) | 2015-03-03 | 2018-05-08 | Soroco Private Limited | Software robots for programmatically controlling computer programs to perform tasks |
| EP3265559B1 (en) | 2015-03-03 | 2021-01-06 | The General Hospital Corporation | Engineered crispr-cas9 nucleases with altered pam specificity |
| US10777397B2 (en) | 2015-03-06 | 2020-09-15 | Micromass Uk Limited | Inlet instrumentation for ion analyser coupled to rapid evaporative ionisation mass spectrometry (“REIMS”) device |
| EP3265180A4 (en) | 2015-03-06 | 2019-04-24 | The University of North Carolina at Chapel Hill | HUMAN FIBROLAMELLAR HEPATOCELLULAR CARCINOMAS (HFL-HCCS) |
| EP3267994A4 (en) | 2015-03-09 | 2018-10-31 | Intekrin Therapeutics, Inc. | Methods for the treatment of nonalcoholic fatty liver disease and/or lipodystrophy |
| JP6719449B2 (en) | 2015-03-18 | 2020-07-08 | 小野薬品工業株式会社 | Method for producing naive pluripotent stem cells |
| WO2016154330A1 (en) | 2015-03-23 | 2016-09-29 | Whitehead Institute For Biomedical Research | Reporter of genomic methylation and uses thereof |
| ES2974281T3 (en) | 2015-04-07 | 2024-06-26 | Intercept Pharmaceuticals Inc | Pharmaceutical compositions for combination therapy |
| US10087417B2 (en) | 2015-04-22 | 2018-10-02 | William J. Freed | Three-dimensional model of human cortex |
| US10557124B2 (en) | 2015-04-22 | 2020-02-11 | The Regents Of The University Of Michigan | Compositions and methods for obtaining stem cell derived lung tissue, and related uses thereof |
| CN104877964A (en) | 2015-04-24 | 2015-09-02 | 赵振民 | In vitro construction method for salivary glands organs and acinus |
| PE20180690A1 (en) | 2015-04-27 | 2018-04-23 | Intercept Pharmaceuticals Inc | OBETICOLIC ACID COMPOSITIONS AND METHODS OF USE |
| US10900018B2 (en) | 2015-04-30 | 2021-01-26 | Helmholtz Zentrum München—Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Means and methods for generation of breast stem cells |
| WO2016179243A1 (en) | 2015-05-05 | 2016-11-10 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Reversion of primed pluripotent stem cells to naive pluripotent stem cells |
| US11299714B2 (en) | 2015-05-11 | 2022-04-12 | The Trustees Of Columbia University In The City Of New York | Engineered adult-like human heart tissue |
| US10913932B2 (en) | 2015-06-03 | 2021-02-09 | Takara Bio Europe Ab | Maturation of mammalian hepatocytes |
| GB201510950D0 (en) | 2015-06-22 | 2015-08-05 | Cambridge Entpr Ltd | In vitro Production of Cholangiocytes |
| US11136548B2 (en) | 2015-06-24 | 2021-10-05 | Whitehead Institute For Biomedical Research | Culture medium for generating microglia from pluripotent stem cells and related methods |
| EP3313416A4 (en) | 2015-06-26 | 2019-02-20 | The Trustees of Columbia University in the City of New York | GENETICALLY MODIFIED IPS CELLS HAVING A MARKER FOR SIGNALING THE EXPRESSION OF NEUROGENIN3, TPH2, FOXO1 AND / OR INSULIN GENES |
| EP3320086B1 (en) | 2015-07-10 | 2025-02-12 | Etablissement Français du Sang | Method for obtaining human brown/beige adipocytes |
| US10449221B2 (en) | 2015-07-29 | 2019-10-22 | Trustees Of Boston University | Differentiation of stem cells into thyroid tissue |
| EP3328399B1 (en) | 2015-07-31 | 2023-12-27 | Regents of the University of Minnesota | Modified cells and methods of therapy |
| US10815460B2 (en) | 2015-09-03 | 2020-10-27 | The Brigham And Women's Hospital, Inc. | Three-dimensional differentiation of epiblast spheroids to kidney organoids models stage-specific epithelial physiology, morphogenesis, and disease |
| WO2017036533A1 (en) | 2015-09-03 | 2017-03-09 | Ecole Polytechnique Federale De Lausanne (Epfl) | Three-dimensional hydrogels for culturing adult epithelial stem cells and organoids |
| WO2017048193A1 (en)* | 2015-09-15 | 2017-03-23 | Agency For Science, Technology And Research (A*Star) | Derivation of liver organoids from human pluripotent stem cells |
| SG10202002323UA (en) | 2015-09-16 | 2020-05-28 | Tobira Therapeutics Inc | Cenicriviroc combination therapy for the treatment of fibrosis |
| WO2017049243A1 (en) | 2015-09-17 | 2017-03-23 | Bonventre Joseph V | Methods of generating nephrons from human pluripotent stem cells |
| US20180273904A1 (en) | 2015-10-02 | 2018-09-27 | Wake Forest University Health Sciences | Spontaneously beating cardiac organoid constructs and integrated body-on-chip apparatus containing the same |
| LU92845B1 (en) | 2015-10-08 | 2017-05-02 | Univ Du Luxembourg Campus Belval | Means and methods for generating midbrain organoids |
| WO2017070007A2 (en) | 2015-10-15 | 2017-04-27 | Wake Forest University Health Sciences | Methods of producing in vitro liver constructs and uses thereof |
| US10993433B2 (en) | 2015-10-15 | 2021-05-04 | Wake Forest University Health Sciences | Method of producing in vitro testicular constructs and uses thereof |
| JP7011828B2 (en) | 2015-10-16 | 2022-01-27 | ウェイク・フォレスト・ユニヴァーシティ・ヘルス・サイエンシズ | Multilayer airway organoids and how to prepare and use them |
| US10801068B2 (en) | 2015-10-16 | 2020-10-13 | The Trustees Of Columbia University In The City Of New York | JAG1 expression predicts therapeutic response in NASH |
| US12209253B2 (en) | 2016-08-29 | 2025-01-28 | EMULATE, Inc. | Development of spinal cord on a microfluidic chip |
| KR102410389B1 (en) | 2015-10-19 | 2022-06-16 | 에뮬레이트, 인크. | Microfluidic Model of the Blood Brain Barrier |
| JP6976939B2 (en) | 2015-10-20 | 2021-12-08 | フジフィルム セルラー ダイナミクス,インコーポレイテッド | Creation of multilineage hematopoietic progenitor cells by genetic programming |
| EP3365428B1 (en) | 2015-10-21 | 2024-09-04 | Indiana University Research & Technology Corporation | Methods of generating human inner ear sensory epithelia and sensory neurons |
| WO2017070506A1 (en) | 2015-10-21 | 2017-04-27 | Indiana University Research And Technology Corporation | Derivation of human skin organoids from pluripotent stem cells |
| SG10202104041PA (en) | 2015-10-23 | 2021-06-29 | Harvard College | Nucleobase editors and uses thereof |
| US11154573B2 (en) | 2015-10-30 | 2021-10-26 | The Regents Of The University Of California | Methods of generating T-cells from stem cells and immunotherapeutic methods using the T-cells |
| WO2017077535A1 (en) | 2015-11-02 | 2017-05-11 | Carmel-Haifa University Economic Corporation Ltd. | Apoptosis related protein in the tgf-beta signaling pathway (arts) mimetic compounds, compositions, methods and uses thereof in induction of differentiation and/or apoptosis of premalignant and malignant cells, thereby restoring their normal-like phenotype |
| WO2017079632A1 (en) | 2015-11-04 | 2017-05-11 | Cedars-Sinai Medical Center | Patient-derived ctc-xenograft models |
| RU2018120599A (en) | 2015-11-06 | 2019-12-09 | Джемфир Терапьютикс, Инк. | TREATMENT OF MIXED DYSLIPIDEMIA |
| WO2017083696A1 (en) | 2015-11-11 | 2017-05-18 | The Regents Of The University Of California | Degradable intestinal anchor |
| US10265153B2 (en) | 2015-11-12 | 2019-04-23 | Biostage, Inc. | Systems and methods for producing gastrointestinal tissues |
| WO2017083705A1 (en) | 2015-11-13 | 2017-05-18 | The Johns Hopkins University | Cell culture system and method of use thereof |
| CA3007366A1 (en) | 2015-12-04 | 2017-06-08 | EMULATE, Inc. | Devices and methods for simulating a function of a liver tissue |
| AU2016362491B2 (en) | 2015-12-04 | 2021-04-29 | President And Fellows Of Harvard College | Devices for simulating a function of a liver tissue and methods of use and manufacturing thereof |
| EP3414322A4 (en) | 2015-12-23 | 2020-03-04 | Memorial Sloan-Kettering Cancer Center | CELL-BASED TREATMENT AND MEDICINE DISCOVERY IN MORBUS HIRSCHSPRUNG, ACTIVATED BY HUMAN ENTERIC NEURAL LATERAL LINES DERIVED FROM PLURIPOTENTIC STEM CELLS |
| EP3397753B1 (en) | 2015-12-30 | 2021-10-27 | FUJIFILM Cellular Dynamics, Inc. | Microtissue formation using stem cell-derived human hepatocytes |
| KR101733137B1 (en) | 2015-12-30 | 2017-05-08 | (주)엑셀세라퓨틱스 | Method of production for 3D cartilage organoid block |
| WO2017117547A1 (en) | 2015-12-31 | 2017-07-06 | President And Fellows Of Harvard College | Methods for generating neural tissue and uses thereof |
| US20190367868A1 (en) | 2015-12-31 | 2019-12-05 | President And Fellows Of Harvard College | Neurons and compositions and methods for producing the same |
| US11021687B2 (en) | 2016-01-08 | 2021-06-01 | The Brigham And Women's Hospital, Inc. | Production of differentiated enteroendocrine cells and insulin producing cells |
| EP3190176A1 (en) | 2016-01-11 | 2017-07-12 | IMBA-Institut für Molekulare Biotechnologie GmbH | Method for tissue culture development on scaffold and differentiated tissue culture |
| WO2017123791A1 (en) | 2016-01-14 | 2017-07-20 | Ohio State Innovation Foundation | A neural organoid composition and methods of use |
| US20170205396A1 (en) | 2016-01-15 | 2017-07-20 | Salk Institute For Biological Studies | Systems and methods for culturing nephron progenitor cells |
| CA3013357A1 (en) | 2016-02-01 | 2017-08-10 | Cedars-Sinai Medical Center | Systems and methods for growth of intestinal cells in microfluidic devices |
| JP7174408B2 (en) | 2016-02-10 | 2022-11-17 | ウェイク・フォレスト・ユニヴァーシティ・ヘルス・サイエンシズ | Liver fibrosis model system and method of making and using same |
| US12156890B2 (en) | 2016-02-11 | 2024-12-03 | The Johns Hopkins University | Compositions and methods for neuralgenesis |
| WO2017143100A1 (en) | 2016-02-16 | 2017-08-24 | The Board Of Trustees Of The Leland Stanford Junior University | Novel recombinant adeno-associated virus capsids resistant to pre-existing human neutralizing antibodies |
| US20190100724A1 (en) | 2016-02-18 | 2019-04-04 | Keio University | Cell culture medium, culture method, and organoid |
| JP7097814B2 (en) | 2016-02-19 | 2022-07-08 | プロセラ セラピューティクス アーベー | Genetic markers for engraftment of human ventricular progenitor cells |
| US20170267970A1 (en) | 2016-02-29 | 2017-09-21 | Whitehead Institute For Biomedical Research | Three-Dimensional Hydrogels that Support Growth of Physiologically Relevant Tissue and Methods of Use Thereof |
| GB201603569D0 (en) | 2016-03-01 | 2016-04-13 | Koninklijke Nederlandse Akademie Van Wetenschappen | Improved differentiation method |
| CN109153962A (en) | 2016-03-08 | 2019-01-04 | 耶路撒冷希伯来大学的益生研究开发有限公司 | Methods and systems for continuous biosensing |
| EP3430132B1 (en) | 2016-03-14 | 2025-04-30 | Agency for Science, Technology and Research | Generation of midbrain-specific organoids from human pluripotent stem cells |
| US10772863B2 (en) | 2016-03-15 | 2020-09-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | Methods of inducing metabolic maturation of human pluripotent stem cells— derived hepatocytes |
| US20190076482A1 (en) | 2016-03-15 | 2019-03-14 | The Johns Hopkins University | Enhanced organoid formation and intestinal stem cell renewal |
| JP6960140B2 (en) | 2016-03-16 | 2021-11-05 | 公立大学法人横浜市立大学 | Tumor tissue reproduction method |
| JP7002530B2 (en) | 2016-03-29 | 2022-02-04 | エスエムエスバイオテック インコーポレイテッド | Compositions and Methods Using Small Motility Stem Cells |
| WO2017176810A1 (en) | 2016-04-04 | 2017-10-12 | Biotime, Inc. | Pluripotent stem cell-derived 3d retinal tissue and uses thereof |
| MX2018012143A (en) | 2016-04-04 | 2019-10-09 | Humeltis | Diagnostic methods for patient specific therapeutic decision making in cancer care. |
| EP3228306A1 (en) | 2016-04-04 | 2017-10-11 | ratiopharm GmbH | Complex compound comprising obeticholic acid and cyclodextrin and pharmaceutical formulation comprising the complex compound |
| JP6935101B2 (en) | 2016-04-05 | 2021-09-15 | 学校法人自治医科大学 | How to reestablish stem cells |
| US12285464B2 (en) | 2016-04-18 | 2025-04-29 | The Trustees Of Columbia University In The City Of New York | Therapeutic targets involved in the progression of nonalcoholic steatohepatitis (NASH) |
| AU2017253228B2 (en) | 2016-04-22 | 2020-04-09 | Taiwanj Pharmaceuticals Co., Ltd. | Nalmefene, naltrexone or derivatives thereof for use in treating (non)-alcoholic steatohepatitis or non-alcoholic fatty liver disease |
| US20170321188A1 (en) | 2016-05-04 | 2017-11-09 | The Research Foundation For The State University Of New York | Methods of generating retinal progenitor cell preparations and uses thereof |
| JP6963882B2 (en) | 2016-05-05 | 2021-11-10 | チルドレンズ ホスピタル メディカル センター | Methods for the in vitro production of fundic tissue and compositions associated with such methods. |
| AU2017269364B2 (en) | 2016-05-25 | 2023-08-31 | Salk Institute For Biological Studies | Compositions and methods for organoid generation and disease modeling |
| US20170349659A1 (en) | 2016-06-03 | 2017-12-07 | The Board Of Trustees Of The Leland Stanford Junior University | Wnt signaling agonist molecules |
| KR20190023067A (en) | 2016-06-14 | 2019-03-07 | 첼플리 에스.알.엘. | Screening kit and method |
| US12129491B2 (en) | 2016-06-15 | 2024-10-29 | Children's Medical Center Corporation | Methods and compositions relating to lung cell differentiation |
| US10221395B2 (en) | 2016-06-16 | 2019-03-05 | Cedars-Sinai Medical Center | Efficient method for reprogramming blood to induced pluripotent stem cells |
| GB201610748D0 (en) | 2016-06-20 | 2016-08-03 | Koninklijke Nederlandse Akademie Van Wetenschappen | Improved diffrentation method |
| GB201611982D0 (en) | 2016-07-11 | 2016-08-24 | Cellesce Ltd | Cell culture |
| EP3275997A1 (en) | 2016-07-28 | 2018-01-31 | QGel SA | Hydrogel precursor formulation and the use thereof |
| KR20230170142A (en) | 2016-08-02 | 2023-12-18 | 메모리얼 슬로안 케터링 캔서 센터 | Treating metastatic cancer and model systems for metastatic disease |
| KR102534195B1 (en) | 2016-08-03 | 2023-05-19 | 웨이크 포리스트 유니버시티 헬스 사이언시즈 | Cancer modeling platform and how to use it |
| EP3494213A4 (en) | 2016-08-04 | 2020-01-08 | Wake Forest University Health Sciences | Blood brain barrier model and methods of making and using the same |
| EP3505620B1 (en) | 2016-08-24 | 2023-07-26 | Keio University | 2d organoid for infection and culture of human diarrhea virus, and use of said 2d organoid |
| JP7262385B2 (en) | 2016-08-26 | 2023-04-21 | ザ・カウンシル・オブ・ザ・クィーンズランド・インスティテュート・オブ・メディカル・リサーチ | cardiomyocyte maturation |
| CA3035233A1 (en) | 2016-08-28 | 2018-03-08 | Baylor College Of Medicine | A novel chicken egg-based metastasis model for cancer |
| WO2018044940A1 (en) | 2016-08-30 | 2018-03-08 | Beth Israel Deaconess Medical Center | Compositions and methods for treating a tumor suppressor deficient cancer |
| EP3506944A4 (en) | 2016-08-30 | 2020-03-25 | Beth Israel Deaconess Medical Center, Inc. | COMPOSITIONS AND METHODS FOR TREATING TUMOR SUPPRESSOR-DEFICIENT CANCER |
| AU2017340634B2 (en) | 2016-10-05 | 2022-06-02 | FUJIFILM Cellular Dynamics, Inc. | Generating mature lineages from induced pluripotent stem cells with MECP2 disruption |
| EP3534907A4 (en) | 2016-11-04 | 2020-06-24 | Children's Hospital Medical Center | COMPOSITIONS AND METHODS FOR TREATING LIVER DISEASES |
| EP3323882A1 (en) | 2016-11-18 | 2018-05-23 | Ecole Polytechnique Fédérale de Lausanne | Organoid tissue engineering |
| KR102559192B1 (en) | 2016-11-23 | 2023-07-27 | 몰포셀 테크놀로지스 인코포레이티드 | encapsulated liver tissue |
| AU2017373767B2 (en) | 2016-12-05 | 2021-09-16 | Children's Hospital Medical Center | Colonic organoids and methods of making and using same |
| GB201622222D0 (en) | 2016-12-23 | 2017-02-08 | Cs Genetics Ltd | Reagents and methods for molecular barcoding of nucleic acids of single cells |
| US10463717B2 (en) | 2016-12-27 | 2019-11-05 | Adocia | Compositions in the form of an injectable aqueous solution comprising amylin, an amylin receptor agonist or an amylin analog, and a co-polyamino acid |
| WO2018170280A1 (en) | 2017-03-15 | 2018-09-20 | University Of Washington | Methods and compositions for enhancing cardiomyocyte maturation and engraftment |
| WO2018191673A1 (en) | 2017-04-14 | 2018-10-18 | Children's Hospital Medical Center | Multi donor stem cell compositions and methods of making same |
| US20210115366A1 (en) | 2017-04-24 | 2021-04-22 | Children's Hospital Medical Center | Methods of making improved human intestinal organoid compositions via application of strain and human intestinal organoid compositions thereof |
| EP3395942A1 (en) | 2017-04-25 | 2018-10-31 | IMBA-Institut für Molekulare Biotechnologie GmbH | Bi- or multi-differentiated organoid |
| US11857697B2 (en) | 2017-05-31 | 2024-01-02 | The Regents Of The University Of Michigan | Compositions and methods for obtaining 3-dimensional lung-like epithelium and related uses thereof |
| IL270714B1 (en) | 2017-06-09 | 2025-09-01 | Childrens Hospital Med Ct | Liver organoid compositions and methods of making and using same |
| JP7008294B2 (en) | 2017-06-13 | 2022-02-10 | 大日本印刷株式会社 | Intestinal organoids and their preparation methods |
| US20200199541A1 (en) | 2017-06-16 | 2020-06-25 | Imba - Institut Für Molekulare Biotechnologie Gmbh | Blood vessel organoid, methods of producing and using said organoids |
| WO2019060336A1 (en) | 2017-09-20 | 2019-03-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | In vitro generation of thymic organoid from human pluripotent stem cells |
| CA3077442A1 (en) | 2017-10-10 | 2019-04-18 | Children's Hospital Medical Center | Esophageal tissue and/or organoid compositions and methods of making same |
| US12379372B2 (en) | 2017-12-21 | 2025-08-05 | Children's Hospital Medical Center | Digitalized human organoids and methods of using same |
| US11279915B2 (en) | 2018-01-12 | 2022-03-22 | Maine Medical Center Research Institute | Methods, compositions, and kits for producing beige adipocytes and treating metabolic disorders |
| AR115304A1 (en) | 2018-03-29 | 2020-12-23 | Univ North Carolina Chapel Hill | STEM / PROGENITOR CELLS OF THE DUODENAL BRUNNER GLANDS AND METHODS FOR THEIR ISOLATION AND USE |
| SG11202100533VA (en) | 2018-07-26 | 2021-02-25 | Childrens Hospital Med Ct | Hepato-biliary-pancreatic tissues and methods of making same |
| JP2021535753A (en) | 2018-09-12 | 2021-12-23 | チルドレンズ ホスピタル メディカル センター | Organoid composition for the production of hematopoietic stem cells and their derivatives |
| JP2022500058A (en) | 2018-09-27 | 2022-01-04 | チルドレンズ ホスピタル メディカル センター | Liver Support System Containing Liver Organoids and Its Manufacturing and Usage |
| BR112021006885A2 (en) | 2018-10-12 | 2021-07-13 | Salk Institute For Biological Studies | cells, islets and organoids that escape detection of immunity and autoimmunity, production methods and their use |
| US11649434B2 (en) | 2018-11-08 | 2023-05-16 | The Regents Of The University Of Michigan | Compositions and methods for obtaining functional basal-like cells |
| JP7410518B2 (en) | 2018-11-15 | 2024-01-10 | Jsr株式会社 | Method for producing brain organoids |
| KR102221230B1 (en) | 2018-12-20 | 2021-03-02 | 한국화학연구원 | Manufacturing method of 3D lung organoids containing alveolar macrophage-like cells derived from human stem cells |
| EP3914694A1 (en) | 2019-01-22 | 2021-12-01 | Massachusetts Institute of Technology | In vitro human blood brain barrier |
| WO2020160371A1 (en) | 2019-02-01 | 2020-08-06 | The University Of Hong Kong | Innervated organoid compositions and methods of making same |
| EP3966315A1 (en) | 2019-05-09 | 2022-03-16 | FUJIFILM Cellular Dynamics, Inc. | Methods for the production of hepatocytes |
| CA3141814A1 (en) | 2019-05-31 | 2020-12-03 | Children's Hospital Medical Center | Shaped organoid compositions and methods of making same |
| US20220221445A1 (en) | 2019-06-03 | 2022-07-14 | The Board of TrusteesoftheLelandStanfordJuniorUniversity | Uses of patient-derived intestinal organoids for celiac disease diagnosis screening and treatment |
| CN110371967A (en) | 2019-07-26 | 2019-10-25 | 苏州中材非金属矿工业设计研究院有限公司 | A kind of graphite flakes low-quality low concentration protection extraction process |
| WO2021021503A1 (en) | 2019-07-26 | 2021-02-04 | The Children's Medical Center Corporation | Use of alveolar or airway organoids for the treatment of lung diseases and disorders |
| WO2021030373A1 (en) | 2019-08-13 | 2021-02-18 | Children's Hospital Medical Center | Improved methods for making organoid compositions |
| CA3150015A1 (en) | 2019-08-28 | 2021-03-04 | Children's Hospital Medical Center | Organoid mesoderm lineage diversification |
| WO2021087508A1 (en) | 2019-10-28 | 2021-05-06 | Children's Hospital Medical Center | Methods relating to sepsis associated acute kidney injury |
| GB201918586D0 (en) | 2019-12-17 | 2020-01-29 | Patterson James | Engineered platelets for targeted delivery of a therapeutic agent |
| US12188051B2 (en) | 2020-05-27 | 2025-01-07 | The Regents Of The University Of Michigan | Compositions and methods for obtaining vascularized human intestinal organoid tissue, and related uses thereof |
| US20230235316A1 (en) | 2020-06-23 | 2023-07-27 | Children's Hospital Medical Center | Model for insulin resistance |
| EP4352206A2 (en) | 2021-06-11 | 2024-04-17 | Children's Hospital Medical Center | Liver organoid model for hyperbilirubinemia and methods of making and using same |
| WO2023023180A1 (en) | 2021-08-19 | 2023-02-23 | Children’S Hospital Medical Center | Vascularized organoids |
| US20250123274A1 (en) | 2021-08-30 | 2025-04-17 | Versitech Limited | Alveolar organoids, methods of making and uses thereof |
| US20230251275A1 (en) | 2022-02-01 | 2023-08-10 | Children's Hospital Medical Center | Npersevere: biomarkers estimating baseline mortality risk for neonatal sepsis and necrotizing enterocolitis |