SG11201909710XA - Indole ahr inhibitors and uses thereof - Google Patents

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 25 October 2018 (25.10.2018) omit VIII °nolo VIII (10) International Publication Number WO 2018/195397 A3 WIPO I PCT (51) International Patent Classification: A01N 63/00 (2006.01) A61K 31/44 (2006.01) A61K 31/40 (2006.01) (21) International Application Number: PCT/US2018/028532 (22) International Filing Date: 20 April 2018 (20.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/488,476 21 April 2017 (21.04.2017) US 62/592,542 30 November 2017 (30.11.2017) US 62/658,454 16 April 2018 (16.04.2018) US (71) Applicant: KYN THERAPEUTICS [US/US]; 400 Tech- nology Square, 10th Floor, Cambridge, Massachusetts 02139 (US). (72) Inventors: CASTRO, Alfredo C.; 14 Kelly Drive, Woburn, Massachusetts 01801 (US). EVANS, Catherine Anne; 83 Jaques Street, Somerville, Massachusetts 02145 (US). (74) Agent: REID, Andrea L.C. et al.; One International Place, 100 Oliver Street, 40th Floor, Boston, Massachusetts 02110-2605 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (88) Date of publication of the international search report: 13 December 2018 (13.12.2018) O (57) : The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using 0 the same. (54) Title: INDOLE AHR INHIBITORS AND USES THEREOF