SG11201908472VA - Compositions and methods for activating nk cells - Google Patents

Abstract

PUBLISHEDUNDER THE PATENT COOPERATION TREATY (PCT) Hu omit VIII °nolo HE oimIE () International Publication Number WO 2018/152340 Al WIPO I PCT (51) International Patent Classification: A61P 35/00 (2006.01) Cl 2N 5/078 (2010.01) A61K 35/15 (2015.01) A61K 35/32 (2015.01) A61K 35/17 (2015.01) A61K 35/741 (2015.01) (21) International Application Number: PCT/US2018/018389 (22) International Filing Date: 15 February 2018 (15.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/459,397 15 February 2017 (15.02.2017) US (71) Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, Twelfth Floor, Oakland, CA 94607-5200 (US). (72) Inventor: JEWETT, Anahid; 24913 Knollwood Land, Valencia, CA 91355 (US). (74) Agent: HALSTEAD, David P. et al.; Foley Hoag LLP, 155 Seaport Boulevard, Boston, MA 02210-2600 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: 71' with international search report (Art. 21(3)) 1-1 013 O (57) : The present application relates to methods of activating a NK cells in vitro, ex vivo, and/or in vivo by an osteoclast cell 0 (OC) and/or a dendritic cell, and methods of treating disease using these activated NK cells. (12) INTERNATIONAL APPLICATION (19) World Intellectual Property Organization International Bureau (43) International Publication Date 23 August 2018 (23.08.2018) (54) Title: COMPOSITIONS AND METHODS FOR ACTIVATING NK CELLS