SG11201908280SA - "chimeric molecules and uses thereof" - Google Patents

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) WIPO I PCT (51) International Patent Classification: TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, CO7K 19/00 (2006.01) CO7K 14/165 (2006.01) KM, ML, MR, NE, SN, TD, TG). C07K 14/11 (2006.01) CO7K 14/08 (2006.01) CO7K 14/115 (2006.01) A61P 31/14 (2006.01) Published: C07K 14/15 (2006.01) — with international search report (Art. 21(3)) (21) International Application Number: PCT/AU2018/050299 (22) International Filing Date: ~~ll~~~~~~~~ 011101010VIIIOH olo olomim oviiiin mom ow (10) International Publication Number WO 2018/176103 Al (25) Filing Language: (26) Publication Language: (30) Priority Data: 2017901152 29 March 2018 (29.03.2018) English English 30 March 2017 (30.03.2017) AU (71) Applicant: THE UNIVERSITY OF QUEENSLAND [AU/AU]; The University of Queensland, St Lucia, Queens- land 4072 (AU). (72) Inventors: CHAPPELL, Keith, Joseph; The University of Queensland, St Lucia, Queensland 4072 (AU). WAT- TERSON, Daniel; The University of Queensland, St Lucia, Queensland 4072 (AU). YOUNG, Paul, Robert; The Uni- versity of Queensland, St Lucia, Queensland 4072 (AU). = (74) Agent: DAVIES COLLISON CAVE PTY LTD; 10/301 Coronation Drive, Milton, Queensland 4064 (AU). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 1-1 Cr) O 1-1 N 00 O C 1-1 1-1 (54) Title: \"CHIMERIC MOLECULES AND USES THEREOF\" (57) : Disclosed are chimeric polypeptides based on viral membrane fusion proteins. More particularly, the present invention discloses chimeric polypeptides that comprise a virion surface exposed portion of a viral fusion protein and a heterologous structure- stabilizing moiety, and to complexes of those chimeric polypeptides. The present invention also discloses the use of these complexes in compositions and methods for eliciting an immune response to a fusion protein of an enveloped virus, or complex of the fusion protein, and/or for treating or preventing an enveloped virus infection. The present invention further discloses the use of the heterologous structure-stabilizing moiety for oligomerizing heterologous molecules of interest.