SG11201900602XA - Polymer-free drug eluting vascular stents - Google Patents

Abstract

OO cc O O () INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 22 March 2018 (22.03.2018) WIP0 I PCT onion °nolo olmoolioin om mu oimIE (10) International Publication Number WO 2018/050916 Al (51) International Patent Classification: A61L 31/08 (2006.01) A61L 31/16 (2006.01) (21) International Application Number: PCT/EP2017/073622 (22) International Filing Date: 19 September 2017 (19.09.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/396,248 19 September 2016 (19.09.2016) US 62/437,685 22 December 2016 (22.12.2016) US (71) Applicant: BIOTRONIK AG [CH/CH]; Ackerstrasse 6, 8180 Buelach (CH). (72) Inventor: BETTS, Ronald. E.; 6435 Muirlands Drive, La Jolla, California 92037 (US). (74) Agent: RANDOLL, Soren; BIOTRONIK SE & Co. KG, Woermannkehre 1, 12359 Berlin (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.1700) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (54) Title: POLYMER-FREE DRUG ELUTING VASCULAR STENTS Drug ElogPoct Sirolimus 6.4 Everolimus 6.7 Biolimus A9 7.4 CRC-015 9.4 FIG. 1 (57) : This application relates generally to the field of implants and more specifically to drug eluting vascular stents and methods of making and using same. Specifically, this technology relates to controlled release of drug from an implant and particular from a stent without the presence of polymer or alteration of the implant surface.