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SG11201809859VA - Benzazepine derivative, preparation method, pharmaceutical composition and use thereof - Google Patents

Benzazepine derivative, preparation method, pharmaceutical composition and use thereof

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Publication number
SG11201809859VA
SG11201809859VASG11201809859VASG11201809859VASG11201809859VASG 11201809859V ASG11201809859V ASG 11201809859VASG 11201809859V ASG11201809859V ASG 11201809859VASG 11201809859V ASG11201809859V ASG 11201809859VASG 11201809859V ASG11201809859V ASG 11201809859VA
Authority
SG
Singapore
Prior art keywords
pharmaceutical composition
preparation
benzazepine
tlr
tlr8
Prior art date
Application number
SG11201809859VA
Inventor
Daxin Gao
Yuxun Wang
Shoujun Chen
Heping Yang
Original Assignee
Shanghai De Novo Pharmatech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai De Novo Pharmatech Co LtdfiledCriticalShanghai De Novo Pharmatech Co Ltd
Publication of SG11201809859VApublicationCriticalpatent/SG11201809859VA/en

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Abstract

Disclosed is a benzazepine derivative, a preparation method, a pharmaceutical composition and a use thereof. A compound of the formula (I), an isomer thereof, a prodrug, a stable isotope derivative or a pharmaceutically acceptable salt of the present invention has the following structure. The benzazepine derivatives of the present invention have a good regulatory effect on the TLR family and related signaling pathways, and particularly have a good regulatory effect on TLR8. The benzazepine derivatives can effectively treat, alleviate and/or prevent diseases mediated by TLR family and TLR-related signaling pathways, in particular, can effectively treat, alleviate and/or prevent various diseases mediated by TLR8, such as cancer, autoimmune diseases, infection, inflammation, transplant rejection, graft versus host disease, and the like.
SG11201809859VA2016-05-062017-05-04Benzazepine derivative, preparation method, pharmaceutical composition and use thereofSG11201809859VA (en)

Applications Claiming Priority (6)

Application NumberPriority DateFiling DateTitle
CN2016102967482016-05-06
CN2016105892192016-07-25
CN2016109653602016-11-04
CN2017100202982017-01-12
CN2017100540382017-01-24
PCT/CN2017/083031WO2017190669A1 (en)2016-05-062017-05-04Benzazepine derivative, preparation method, pharmaceutical composition and use thereof

Publications (1)

Publication NumberPublication Date
SG11201809859VAtrue SG11201809859VA (en)2018-12-28

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Family Applications (1)

Application NumberTitlePriority DateFiling Date
SG11201809859VASG11201809859VA (en)2016-05-062017-05-04Benzazepine derivative, preparation method, pharmaceutical composition and use thereof

Country Status (22)

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US (1)US10669252B2 (en)
EP (1)EP3453707B1 (en)
JP (1)JP6739548B2 (en)
KR (1)KR102274557B1 (en)
CN (1)CN107344931B (en)
AU (1)AU2017259654B2 (en)
CA (1)CA3023154C (en)
CY (1)CY1126367T1 (en)
DK (1)DK3453707T3 (en)
ES (1)ES2907981T3 (en)
HR (1)HRP20220577T1 (en)
HU (1)HUE057924T2 (en)
LT (1)LT3453707T (en)
MX (1)MX382727B (en)
PH (1)PH12018502336A1 (en)
PL (1)PL3453707T3 (en)
PT (1)PT3453707T (en)
RS (1)RS63116B1 (en)
SG (1)SG11201809859VA (en)
SI (1)SI3453707T1 (en)
SM (1)SMT202200122T1 (en)
WO (1)WO2017190669A1 (en)

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Also Published As

Publication numberPublication date
PH12018502336A1 (en)2019-07-29
KR20190003572A (en)2019-01-09
CA3023154A1 (en)2017-11-09
RS63116B1 (en)2022-05-31
US20190152941A1 (en)2019-05-23
PL3453707T3 (en)2022-06-13
JP2019518728A (en)2019-07-04
SMT202200122T1 (en)2022-05-12
PT3453707T (en)2022-03-15
JP6739548B2 (en)2020-08-12
AU2017259654B2 (en)2020-02-27
HRP20220577T1 (en)2022-06-24
DK3453707T3 (en)2022-05-09
EP3453707A4 (en)2020-01-08
KR102274557B1 (en)2021-07-07
CN107344931A (en)2017-11-14
HUE057924T2 (en)2022-06-28
MX2018013467A (en)2019-07-08
ES2907981T3 (en)2022-04-27
EP3453707A1 (en)2019-03-13
SI3453707T1 (en)2022-04-29
CA3023154C (en)2021-01-12
WO2017190669A1 (en)2017-11-09
CN107344931B (en)2020-09-15
AU2017259654A1 (en)2019-01-03
EP3453707B1 (en)2022-02-16
CY1126367T1 (en)2024-12-13
MX382727B (en)2025-03-13
BR112018072591A2 (en)2019-02-19
LT3453707T (en)2022-03-10
US10669252B2 (en)2020-06-02

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