SG11201809700YA - Gdf15 fusion proteins and uses thereof - Google Patents

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111111111111111111111111111111111111111111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/196647 Al 16 November 2017 (16.11.2017) WIPO I PCT (51) International Patent Classification: San Diego, California 92121 (US). HUANG, Chichi; 1400 A61K 9/00 (2006.01) CO 7K 14/00 (2006.01) McKean Road, Spring House, Pennsylvania 19477 (US). A61K 38/00 (2006.01) C07K 14/495 (2006.01) HUNGER, Michael J.; 3210 Merryfield Row, San Diego, A61K 38/18 (2006.01) C07K 14/765 (2006.01) California 92121 (US). LIN-SCHMIDT, Xiefan; 1400 (21) International Application Number: McKean Road, Spring House, Pennsylvania 19477 (US). NELSON, Serena; 3210 Merryfield Row, San Diego, Cal- PCT/US2017/031197 ifornia 92121 (US). RANGWALA, Shamina; 1400 McK- (22) International Filing Date: can Road, Spring House, Pennsylvania 19477 (US). MUL- 05 May 2017 (05.05.2017) LICAN, Shannon; 1400 McKean Road, Spring House, (25) Filing Language: English Pennsylvania 19477 (US). CHAVEZ, Jose Antonio; 1400 McKean Road, Spring House, Pennsylvania 19477 (US). (26) Publication Language: English (81) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of national protection available): AE, AG, AL, AM, 62/333,886 10 May 2016 (10.05.2016) US AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (71) Applicant: JANSSEN BIOTECH, INC. [US/US]; DZ, EC, EE, EG, ES, FL GB, GD, GE, GH, GM, GT, HN, 800/850 Ridgeview Drive, Horsham, Pennsylvania 19044 HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, (US). KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, — (72) Inventors: ARMSTRONG, Anthony; 1400 McKean MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, Road, Spring House, Pennsylvania 19477 (US). CONNOR, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, Judith Ann; 3210 Merryfield Row, San Diego, California SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, 92121 (US). FURMAN, Jennifer; 3210 Merryfield Row, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = Title: GDF15 FUSION PROTEINS AND USES THEREOF (54) = Figure 1A = = = = = ‘s = gin AV - _ GDF15 = = = = _ _ = _ Il Ir ... ' 71' TG933 0\ 1-1 ---- (57) : Fusion proteins containing a half-life extension protein, a linker, and a GDF15 protein are described. Also described IN ,—I are nucleic acids encoding the fusion proteins, recombinant cells thereof, compositions comprising the fusion proteins, and methods of 0 using the fusion proteins for treating or preventing metabolic diseases, disorders or conditions. ei C [Continued on next page] WO 2017/196647 Al MIDEDIMOMOIDEIROIDEMOMOHEIRIEHOEUVOIMIE (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — with sequence listing part of description (Rule 5.2(a))