SG11201807543YA - Hepatitis b antiviral agents - Google Patents

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 1111111101111011101010111110101111101110111101110111110111011111111101111011111 International Bureau 0... .... ..Yjd (10) International Publication Number ...... ../ (43) International Publication Date WO 2017/155844 Al 14 September 2017 (14.09.2017) WIP0 I PCT (51) International Patent Classification: (74) Agents: HARLAN, Edgar, W. et al.; Elmore Patent Law A61K 31/42 (2006.01) C07D 261/20 (2006.01) Group, 484 Groton Road, Westford, MA 01886 (US). A61K 31/416 (2006.01) (81) Designated States (unless otherwise indicated, for every (21) International Application Number: kind of national protection available): AE, AG, AL, AM, PCT/US2017/020853 AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (22) International Filing Date: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, 6 March 2017 (06.03.2017) HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (25) Filing Language: English KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (26) Publication Language: English NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (30) Priority Data: RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, 62/304,671 7 March 2016 (07.03.2016) US TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, 62/337,675 17 May 2016 (17.05.2016) US ZA, ZM, ZW. (71) Applicant: ENANTA PHARMACEUTICALS, INC. (84) Designated States (unless otherwise indicated, for every [US/US]; 500 Arsenal Street, Watertown, MA 02472 (US). kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, — (72) Inventors: QIU, Yao-Ling; 29 Linda Road, Andover, MA TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, 01810 (US). GAO, Xuri; 179 Allerton Road, Unit 2, New- TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, ton, MA 02461 (US). LI, Wei; 22 April Lane, Lexington, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, MA 02421 (US). CAO, Hui; 53 Hill Road, Belmont, MA LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, — _ 02478 (US). JIN, Meizhong; 64-105 Hastings St., Welles- SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, ley, MA 02481 (US). KASS, Jorden; 29 Wilson Ave, Apt. GW, KM, ML, MR, NE, SN, TD, TG). #2, Belmont, MA 02478 (US). PENG, Xiaowen; 85 Horse Pond Road, Sudbury, MA 01776 (US). OR, Yat, Sun; 169 Published: = Fayette Street, Watertown, MA 02472 (US). — with international search report (Art. 21(3)) = = = = = = = = = = = Il 7r 7r cc kin kin 1-1 (54) Title: HEPATITIS B ANTIVIRAL AGENTS IN (57) : The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs 1-1 C thereof: X-A -Y -L-R (I) which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV N life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical corn- ea ) positions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention 7 1 ,1 9 also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.