INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property , Organization 111111110111101110101H OH 110101011010111IIH H IDIOM MI International Bureau .. .... ..Yejd (10) International Publication Number (43) International Publication Date ..... .....!;,' WO 2016/026981 Al 25 February 2016 (25.02.2016) WIPO I PCT (51) International Patent Classification: cio Biomedica De Bellvitge (idibell), Hospital Duran i A61K 45/06 (2006.01) A61P 31/04 (2006.01) Reynals, 3' planta Gran Via de l'Hospitalet, 199, 08908 A61K 38/14 (2006.01) A61K 31/702 (2006.01) Hospitalet de Llobregat (ES). A61K 31/7016 (2006.01) A61K 31/785 (2006.01) (74) Agent: ALCONADA RODRIGUEZ, Agustin; ABG Pat- A61K 31/7028 (2006.01) entes, S.L., Avenida de Burgos, 16D, Edificio Euromor, E- (21) International Application Number: 28036 Madrid (ES). PCT/EP2015/069334 (81) Designated States (unless otherwise indicated, for every (22) International Filing Date: kind of national protection available): AE, AG, AL, AM, 24 August 2015 (24.08.2015) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, (25) Filing Language: English DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (26) Publication Language: English HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, (30) Priority Data: MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, 14382324.3 22 August 2014 (22.08.2014) EP PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, (71) Applicant: INSTITUT D'INVESTIGACIO BIO- SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, MEDICA DE BELLVITGE (IDIBELL) [ES/ES]; Hos- TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. pital Duran i Reynals, 3' planta Gran Via de l'Hospitalet, (84) Designated States (unless otherwise indicated, for every 199, 08908 Hospitalet de Llobregat (ES). kind of regional protection available): ARIPO (BW, GH, — (72) Inventors: MASEZ MENDILUCE, Rafael; Institut D'in- GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, 5Z, TZ, ZM, ZW), Eurasian AZ, BY, KG, KZ, RU, — vestigacio Biomedica De Bellvitge (idibell), Hospital Dur- UG, (AM, _ TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, an i Reynals, 3' planta Gran Via de l'Hospitalet, 199, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, 08908 Hospitalet de Llobregat (ES). COSTA VALLES, Cristina; Institut D'investigacio Biomedica De Bellvitge LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (idibell), Hospital Duran i Reynals, 3' Gran Via de 1 SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, planta 'Hospitalet, GW, KM, ML, MR, NE, SN, TD, TG). 199, 08908 Hospitalet de Llobregat (ES). = PEREZ CRUZ, Magdiel; Institut D'investigaciO Bio- Published: medica De Bellvitge (idibell), Hospital Duran i Reynals, 3' Gran Via de l'Hospitalet, 199, 08908 Hospitalet de with international search report (Art. 21(3)) planta Llobregat (ES). BELLO GIL, Daniel; Institut D'investiga- - = = = = = = = 1-1 Il GC C:7 ei © 1-1 C:::: ) (54) Title: METHODS AND REAGENTS FOR PREVENTION AND/OR TREATMENT OF INFECTION ei 0 (57) : The present invention relates to the field of therapeutics and, more in particular, to agents and compositions for the ,-t prevention and/or treatment of infection caused by bacteria of the gastrointestinal tract in a subject, said agents and compositions be - .,- ing based on agents comprising a terminal ct-galactosyl moiety.