SG11201806340YA - Zika virus vaccine - Google Patents

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 111111110111101110101011111010111110111010111011011110111111101111101111011111 International Bureau 0.. .1 j ..... ..or::,„, (10) International Publication Number (43) International Publication Date WO 2017/140905 Al 24 August 2017 (24.08.2017) WI P0 I P CT (51) International Patent Classification: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, A61K 39/12 (2006.01) HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (21) International Application Number: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, PCT/EP2017/053721 NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (22) International Filing Date: RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, 17 February 2017 (17.02.2017) TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (25) Filing Language: English (84) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of regional protection available): ARIPO (BW, GH, (30) Priority Data: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, PCT/EP2016/053398 TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, 17 February 2016 (17.02.2016) EP TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (71) Applicants: CUREVAC AG [DE/DE]; Paul-Ehrlich-Str. LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, 15, 72076 Tiibingen (DE). SANOFI PASTEUR SA SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, [FR/FR]; 2, avenue Pont Pasteur, 69367 Lyon Cedex 07 GW, KM, ML, MR, NE, SN, TD, TG). (FR). Declarations under Rule 4.17: (72) Inventors: PETSCH, Benjamin; Hagellocher Weg 44, — of inventorship (Rule 4.17(N)) 72070 Tiibingen (DE). JASNY, Edith; Dorfstr. 70, 72074 Tiibingen (DE). GIRERD-CHAMBAZ, Yves; 22, chemin Published: de la Pra, 69510 Messimy (FR). — with international search report (Art. 21(3)) (74) Agents: VON STOSCH, Andreas et al.; Prinzregentenstr. before limit the expiration of the time for amending the 22, 80538 Munich (DE). claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (81) Designated States (unless otherwise indicated, for every kind AE, AG, AL, AM, of national protection available): _ with sequence listing part of description (Rule 5.2(a)) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, Il ir) 0 01 0 ll• 1-1 (54) Title: ZIKA VIRUS VACCINE I N (57) : The present invention is directed to an artificial nucleic acid and to polypeptides suitable for use in treatment or pro - 11 O phylaxis of an infection with Zika virus or a disorder related to such an infection. In particular, the present invention concerns a Zika N virus vaccine. The present invention is directed to an artificial nucleic acid, polypeptides, compositions and vaccines comprising the O artificial nucleic acid or the polypeptides. The invention further concerns a method of treating or preventing a disorder or a disease, ,-t first and second medical uses of the artificial nucleic acid, polypeptides, compositions and vaccines. Further, the invention is direc - .,. ted to a kit, particularly to a kit of parts, comprising the artificial nucleic acid, polypeptides, compositions and vaccines.