SG11201805497QA - Mutated truncated von willebrand factor - Google Patents

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 11111111011110111010101111101011111011101110101111110111011011111101111011111 International Bureau 0.. .... .. (10) International Publication Number (43) International Publication Date ..... ...r .....1 WO 2017/117631 Al 13 July 2017 (13.07.2017) WI P0 I P CT (51) International Patent Classification: (74) Agent: DAVIS COLLISON CAVE; 1 Nicholson Street, A61K 38/36 (2006.01) C07K 14/745 (2006.01) Melbourne, Victoria 3000 (AU). A61K 38/37 (2006.01) A61P 7/04 (2006.01) (81) Designated States (unless otherwise indicated, for every (21) International Application Number: kind of national protection available): AE, AG, AL, AM, PCT/AU2017/050010 AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (22) International Filing Date: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, 6 January 2017 (06.01.2017) HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (25) Filing Language: English KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (26) Publication Language: English NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (30) Priority Data: RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, 2016900034 7 January 2016 (07.01.2016) AU TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant: CSL LIMITED [AU/AU]; 45 Poplar Road, Parkville, Victoria 3052 (AU). (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, — (72) Inventors: ANDREWS, Arna; C/- CSL Limited, 45 Pop- GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, lar Road, Parkville, Victoria 3052 (AU). PANOUSIS, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, Kosta; C/- CSL Limited, 45 Poplar Road, Parkville, Vic- TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, toria 3052 (AU). EMMRICH, Kerstin; C/- CSL Limited, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, 45 Poplar Road, Parkville, Victoria 3052 (AU). WILSON, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, — _ Michael; C/- CSL Limited, 45 Poplar Road, Parkville, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Victoria 3052 (AU). DOWER, Steve; C/- CSL Limited, 45 GW, KM, ML, MR, NE, SN, TD, TG). Poplar Road, Parkville, Victoria 3052 (AU). HARDY, Mathew; C/- CSL Limited, 45 Poplar Road, Parkville, Published: . Victoria 3052 (AU). HARTMAN, Dallas; C/- CSL Lim- — with international search report (Art. 21(3)) ited, 45 Poplar Road, Parkville, Victoria 3052 (AU). — with sequence listing part of description (Rule 5.2(a)) = = = = = = = = = = 1-1 11 M IN 1-1 1-1 IN 1-1 (54) Title: MUTATED TRUNCATED VON WILLEBRAND FACTOR 0 N (57) : The present invention provides a modified polypeptide which binds Factor VIII. The polypeptide comprises trun- cated von Willebrand Factor (VWF) which comprises a sequence as shown in SEQ ID NO:3 or a fragment thereof or a sequence 90% identical thereto, wherein the truncated VWF comprises at least one modification in comparison to SEQ ID NO: 3 in at least one position selected from the group consisting of SI, S3, LI 8, V42, S43, K149, N248, S279, V320, T325, Q395 and K418.