SG11201804098TA - Purinones as ubiquitin-specific protease 1 inhibitors - Google Patents

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property - Organization International Bureau ... .51d > (43) International Publication Date .. ....7r ,,,,,01 26 May 2017(26.05.2017) WIPO I PCT (10) WO International 111111111111311111111111111111111111111111111111111111111111111111111111111111111111111111 2017/087837 Publication Number Al (51) International Patent Classification: (74) Agents: FARMER, J.Dean et al.; Cooley LLP, 1299 C07D 473/00 (2006.01) A61P 35/00 (2006.01) Pennsylvania Avenue, Suite 700, Washington, District of A61K 31/522 (2006.01) Columbia 20004 (US). (21) International Application Number: (81) Designated States (unless otherwise indicated, for every PCT/US2016/062837 kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (22) International Filing Date: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, 18 November 2016 (18.11.2016) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (25) Filing Language: English HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (26) Publication Language: English MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (30) Priority Data: OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, 62/258,162 20 November 2015 (20.11.2015) US SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (71) Applicant: FORMA THERAPEUTICS, INC. [US/US]; ZW. 500 Arsenal Street, Suite 100, Watertown, Massachusetts 02472 (US). (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (72) Inventors: BUCKMELTER, Alexandre Joseph; 139 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, Prospect Street #5, Acton, Massachusetts 01720 (US). TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, IOANNIDIS, Stephanos; 8 Penobscot Road, Natick, Mas- TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, sachusetts 01760 (US). FOLLOWS, Bruce; 25 Baldwin DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Hill Road, Littleton, Massachusetts 01460 (US). GUST- LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, AFSON, Gary; 33 Ridgecrest Drive, Ridgefield, Connecti- SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, cut (US). 06877 WANG, Minghua; 30 Squirrel Hill, Ac- GW, KM, ML, MR, NE, SN, TD, TG). ton, Massachusetts 01720 (US). CARAVELLA, Justin Declarations Rule 4.17: under A.; 121 Sciarappa Street #3, Cambridge, Massachusetts 02141 (US). WANG, Zhongguo; 19 Earl Street, Lexing- — as to applicant's entitlement to apply for and be granted a ton, Massachusetts 02421 (US). FRITZEN, Edward L.; 2 patent (Rule 4.170) Peach Tree Lane, Niantic, Connecticut 06357 (US). LIN, Published: Jian; 3 Beechnut Street, Acton, Massachusetts 01720 — with international search report (Art 21(3)) (US). (54) Title: PURINONES AS UBIQUITIN-SPECIFIC PROTEASE 1 INHIBITORS Ri \ N 0 — < Xi ,... R X2 1-1 .4t it--- M ot o h o O t-- Il (57) : The application relates R to inhibitors R3 n of USP1 useful in the „t or si R4 treatment I %, ... \" . X .. t. 3 X4 of cancers, and (I), other USP1 associated diseases O and disorders, having the Formula: (I), where RI, R2, R3, R3', R4, R5, X1, X2, X3, X4, and n are described herein. ei 0