SG11201707615YA - Methods and compositions for producing hepatocyte-like cells - Google Patents

Methods and compositions for producing hepatocyte-like cells

Info

Publication number: SG11201707615YA
Authority: SG; Singapore
Prior art keywords: compositions; cells; methods; producing hepatocyte; hepatocyte
Prior art date: 2013-09-19

Univ Leland Stanford Junior

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-09-17Application filed by Univ Leland Stanford JuniorfiledCriticalUniv Leland Stanford Junior

2017-10-30Publication of SG11201707615YApublicationCriticalpatent/SG11201707615YA/en

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/407—Liver; Hepatocytes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/60—Buffer, e.g. pH regulation, osmotic pressure
- C12N2500/62—DMSO
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/12—Hepatocyte growth factor [HGF]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/237—Oncostatin M [OSM]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/602—Sox-2
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/603—Oct-3/4
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/604—Klf-4
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/606—Transcription factors c-Myc
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
- C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
- C12N2506/1384—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from adipose-derived stem cells [ADSC], from adipose stromal stem cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2513/00—3D culture
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Cell Biology (AREA)
Microbiology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Developmental Biology & Embryology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Diabetes (AREA)
Gastroenterology & Hepatology (AREA)
Transplantation (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Physiology (AREA)
Virology (AREA)
Epidemiology (AREA)
Immunology (AREA)
Nutrition Science (AREA)
Emergency Medicine (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Vascular Medicine (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)

SG11201707615YA2013-09-192014-09-17Methods and compositions for producing hepatocyte-like cellsSG11201707615YA (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201361880056P	2013-09-19	2013-09-19
PCT/US2014/056049WO2015042125A2 (en)	2013-09-19	2014-09-17	Methods and compositions for producing hepatocyte-like cells

Publications (1)

Publication Number	Publication Date
SG11201707615YAtrue SG11201707615YA (en)	2017-10-30

Family

ID=52689587

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
SG10201802231RASG10201802231RA (en)	2013-09-19	2014-09-17	Methods and compositions for producing hepatocyte-like cells
SG11201707615YASG11201707615YA (en)	2013-09-19	2014-09-17	Methods and compositions for producing hepatocyte-like cells
SG10201914005TASG10201914005TA (en)	2013-09-19	2014-09-17	Methods and compositions for producing hepatocyte-like cells

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
SG10201802231RASG10201802231RA (en)	2013-09-19	2014-09-17	Methods and compositions for producing hepatocyte-like cells

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
SG10201914005TASG10201914005TA (en)	2013-09-19	2014-09-17	Methods and compositions for producing hepatocyte-like cells

Country Status (8)

Country	Link
US (3)	US10004767B2 (en)
EP (2)	EP3046628B1 (en)
JP (3)	JP6683615B2 (en)
CA (1)	CA2959117C (en)
DK (1)	DK3046628T3 (en)
ES (1)	ES2767062T3 (en)
SG (3)	SG10201802231RA (en)
WO (1)	WO2015042125A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US10767164B2 (en)	2017-03-30	2020-09-08	The Research Foundation For The State University Of New York	Microenvironments for self-assembly of islet organoids from stem cells differentiation
JP2020536632A (en)*	2017-10-05	2020-12-17	ザ・ジョンズ・ホプキンス・ユニバーシティ	Transplantable bioreactor, and how to make and use it
CN109749981B (en)*	2017-11-06	2023-10-10	博品(上海)生物医药科技有限公司	Hepatocyte-like cells derived from human adipose-derived stem cells, and preparation method and application thereof
AU2019342877B2 (en)*	2018-09-20	2025-01-30	Novadip Biosciences	Biomaterial comprising adipose-derived stem cells and gelatin and method for producing the same
CA3175071A1 (en)	2020-03-11	2021-09-16	Bit Bio Limited	Method of generating hepatic cells
WO2023060186A1 (en)	2021-10-07	2023-04-13	Hepatx Corporation	Methods of tracking donor cells in a recipient

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4491632A (en)	1979-10-22	1985-01-01	The Massachusetts General Hospital	Process for producing antibodies to hepatitis virus and cell lines therefor
US4444887A (en)	1979-12-10	1984-04-24	Sloan-Kettering Institute	Process for making human antibody producing B-lymphocytes
DE3167442D1 (en)	1980-07-07	1985-01-10	Nat Res Dev	Improvements in or relating to cell lines
DE3402927A1 (en)	1984-01-28	1985-08-08	Pfeifer & Langen, 5000 Köln	CELL CULTURE MICROCARRIERS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE FOR GROWING ANCHOR-DEPENDENT CELLS
US5026650A (en)	1988-06-30	1991-06-25	The United States Of Amercia As Represented By The Administrator Of The National Aeronautics And Space Administration	Horizontally rotated cell culture system with a coaxial tubular oxygenator
US5800992A (en)	1989-06-07	1998-09-01	Fodor; Stephen P.A.	Method of detecting nucleic acids
US5143854A (en)	1989-06-07	1992-09-01	Affymax Technologies N.V.	Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5631734A (en)	1994-02-10	1997-05-20	Affymetrix, Inc.	Method and apparatus for detection of fluorescently labeled materials
US5605793A (en)	1994-02-17	1997-02-25	Affymax Technologies N.V.	Methods for in vitro recombination
US5807522A (en)	1994-06-17	1998-09-15	The Board Of Trustees Of The Leland Stanford Junior University	Methods for fabricating microarrays of biological samples
US6214618B1 (en)	1998-04-07	2001-04-10	Solohill Engineering, Inc.	Microcarrier beads having a styrene copolymer core and a covalently linked tri-methylamine exterior
US6712610B2 (en)	1999-04-02	2004-03-30	Forsyth Dental Infirmary For Children	Characterization of an antibiotic impregnated delivery system as an intracanal medicament in endodontic therapy and method
PL368119A1 (en)	2001-10-02	2005-03-21	Novo Nordisk Health Care Ag	Method for production of recombinant proteins in eukaryote cells
RU2327479C2 (en)*	2002-03-15	2008-06-27	Юниверсити Оф Норт Каролина Эт Чепел Хилл	Primitive and proximal stem hepatocytes
WO2003080821A1 (en)	2002-03-25	2003-10-02	Japan Science And Technology Agency	Method of proliferating human hepatocytes and method of obtaining human hepatocytes
JP4723862B2 (en)	2002-12-23	2011-07-13	フジフィルムマニュファクチャリングユーロプビー．ブイ．	Method for coating a cell culture support
US7813977B2 (en)	2003-09-11	2010-10-12	Bgc Partners, Inc.	Graphical user interface related to non-standard trading of financial instruments
US7361493B1 (en)	2004-05-26	2008-04-22	The United States Of America As Represented By The Secretary Of The Department Of Veterans Affairs	Production of urokinase in a three-dimensional cell culture
AU2005289088B2 (en)*	2004-09-29	2011-04-07	Cellartis Ab	Methods for the generation of hepatocyte-like cells from human blastocyst-derived stem (hBS)
EP1984488B1 (en)	2006-01-30	2017-12-27	University Of Virginia Patent Foundation	Methods of preparing and characterizing mesenchymal stem cell aggregates and uses thereof
BRPI0710800A2 (en)	2006-04-25	2012-01-17	Univ California	administration of growth factors for the treatment of snc disorders
JP2009535035A (en)*	2006-04-25	2009-10-01	ボードオブスーパーバイザーズオブルイジアナステイトユニバーシティアンドアグリカルチュラルアンドメカニカルカレッジ	Adipocyte-derived adult stem cells in liver regeneration
US7989204B2 (en)*	2006-04-28	2011-08-02	Viacyte, Inc.	Hepatocyte lineage cells
EP2021035B1 (en)*	2006-05-19	2020-08-05	Versitech Limited	Cell-matrix microspheres, methods for preparation and applications
US8158108B2 (en)	2006-06-28	2012-04-17	S.C. Johnson & Son, Inc.	VOC-free compressed gas aerosol compositions
WO2008060360A2 (en)	2006-09-28	2008-05-22	Surmodics, Inc.	Implantable medical device with apertures for delivery of bioactive agents
EP2155065A4 (en)*	2007-05-14	2014-09-10	Univ Johns Hopkins	METHODS FOR IN VIVO IMAGING OF CELLS
EP2179034A1 (en)*	2007-07-20	2010-04-28	Cellartis AB	A novel population of hepatocytes derived via definitive endoderm (de-hep) from human blastocysts stem cells
EP2245141B1 (en)	2008-01-18	2018-03-14	Regents of the University of Minnesota	Stem cell aggregates and methods for making and using
JP2011510750A (en)	2008-01-29	2011-04-07	クライマン、ギルバート・エイチ	Drug delivery device, kit and methods thereof
US20100112031A1 (en)	2008-10-17	2010-05-06	University Of Virginia Patent Foundation	Compositions And Methods For Regulating Extracellular Matrix Production In Adipose Derived Cells
US20100098739A1 (en)	2008-10-20	2010-04-22	University Of Virginia Patent Foundation	Compositions and methods for modular soft tissue repair
WO2010049752A1 (en)*	2008-10-31	2010-05-06	Katholieke Universiteit Leuven	Optimized methods for differentiation of cells into cells with hepatocyte and hepatocyte progenitor phenotypes, cells produced by the methods, and methods for using the cells
US8895300B2 (en)*	2008-11-04	2014-11-25	Viacyte, Inc.	Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof
JP2012509085A (en)	2008-11-20	2012-04-19	ヤンセンバイオテツク，インコーポレーテツド	Culture of pluripotent stem cells on microcarriers
KR101017710B1 (en)*	2009-02-05	2011-02-25	한양대학교 산학협력단	Adult stem cell aggregate for transplantation in cell spheroid form and method for preparing same
WO2010108126A2 (en)	2009-03-19	2010-09-23	Fate Therapeutics, Inc.	Reprogramming compositions and methods of using the same
JP5792714B2 (en)	2009-05-28	2015-10-14	コーニングインコーポレイテッド	Swellable synthetic microcarriers for cell culture
JP2011013535A (en)	2009-07-03	2011-01-20	Olympus Corp	Light controlling apparatus and optical system
US20120282228A1 (en)*	2009-07-15	2012-11-08	Vishal Bhasin	Method of producing progenitor cells from differentiated cells
CN101914495A (en)	2010-07-22	2010-12-15	吉林大学	Culture method for massive expansion of hair follicle stem cells in vitro
ITMI20111096A1 (en)*	2011-06-17	2012-12-18	Filosa Stefania	ENDODERMA CELLS FROM MULTI-TOTAL CELLS
US9215088B2 (en)	2011-06-29	2015-12-15	Broadcom Corporation	Identification of application sessions
WO2013018851A1 (en)*	2011-08-02	2013-02-07	独立行政法人国立がん研究センター	Method for inducing hepatic differentiation from induced hepatic stem cell, and induced hepatic progenitor cell
ES2600321T3 (en)*	2011-08-04	2017-02-08	Ethianum Betriebsgesellschaft Mbh & Co. Kg	Means for liver regeneration

2014
- 2014-09-17SGSG10201802231RApatent/SG10201802231RA/enunknown
- 2014-09-17EPEP14846200.5Apatent/EP3046628B1/enactiveActive
- 2014-09-17EPEP19191062.9Apatent/EP3685884A1/ennot_activeWithdrawn
- 2014-09-17USUS14/917,558patent/US10004767B2/enactiveActive
- 2014-09-17CACA2959117Apatent/CA2959117C/enactiveActive
- 2014-09-17WOPCT/US2014/056049patent/WO2015042125A2/enactiveApplication Filing
- 2014-09-17ESES14846200Tpatent/ES2767062T3/enactiveActive
- 2014-09-17SGSG11201707615YApatent/SG11201707615YA/enunknown
- 2014-09-17JPJP2016543968Apatent/JP6683615B2/enactiveActive
- 2014-09-17SGSG10201914005TApatent/SG10201914005TA/enunknown
- 2014-09-17DKDK14846200.5Tpatent/DK3046628T3/enactive
2018
- 2018-05-08USUS15/974,377patent/US11291691B2/enactiveActive
2020
- 2020-03-26JPJP2020055548Apatent/JP7057797B2/enactiveActive
2022
- 2022-02-15USUS17/672,528patent/US20220168359A1/ennot_activeAbandoned
- 2022-04-08JPJP2022064376Apatent/JP2022088668A/enactivePending

Also Published As

Publication number	Publication date
DK3046628T3 (en)	2020-02-10
EP3685884A1 (en)	2020-07-29
SG10201802231RA (en)	2018-05-30
US20220168359A1 (en)	2022-06-02
JP7057797B2 (en)	2022-04-20
CA2959117C (en)	2023-08-22
US20160256499A1 (en)	2016-09-08
US10004767B2 (en)	2018-06-26
JP2020114237A (en)	2020-07-30
EP3046628A2 (en)	2016-07-27
JP2022088668A (en)	2022-06-14
ES2767062T3 (en)	2020-06-16
SG10201914005TA (en)	2020-03-30
JP6683615B2 (en)	2020-04-22
JP2016529920A (en)	2016-09-29
CA2959117A1 (en)	2015-03-26
US11291691B2 (en)	2022-04-05
WO2015042125A2 (en)	2015-03-26
EP3046628A4 (en)	2017-03-08
US20190083545A1 (en)	2019-03-21
EP3046628B1 (en)	2019-11-06
WO2015042125A3 (en)	2015-11-05

Publication	Publication Date	Title
IL289821A (en)	2022-03-01	Compositions and methods for immunotherapy
IL273205A (en)	2020-04-30	Compositions and methods
HK1218837A1 (en)	2017-03-17	Compositions and methods
HK1218560A1 (en)	2017-02-24	Compositions and methods
GB2527241B (en)	2018-04-11	Compositions and methods
HK1220387A1 (en)	2017-05-05	Compositions and methods for immunotherapy
SG10201706858XA (en)	2017-09-28	Methods and compositions for mobilizing stem cells
SG10201710218RA (en)	2018-01-30	Sc-beta cells and compositions and methods for generating the same
SMT201900635T1 (en)	2020-01-14	Compositions and methods for activating
HK1206755A1 (en)	2016-01-15	Low acidic species compositions and methods for producing and using the same
GB201308072D0 (en)	2013-06-12	Compositions and methods
EP2943591A4 (en)	2016-07-20	Methods and compositions for single cell expression profiling
HK1214772A1 (en)	2016-08-05	Methods for producing diketopiperazines and compositions containing diketopiperazines
ZA201506874B (en)	2017-01-25	Binder compositions and methods for making and using same
IL243235A0 (en)	2016-03-31	Compositions and methods for immunotherapy
GB201305813D0 (en)	2013-05-15	Compositions and methods
ZA201506873B (en)	2017-01-25	Binder compositions and methods for making and using same
SG11201707615YA (en)	2017-10-30	Methods and compositions for producing hepatocyte-like cells
EP2964610A4 (en)	2016-11-23	Vinylsulfone-based 18f-labeling compositions and methods and uses thereof
GB201322456D0 (en)	2014-02-05	Radiotracer compositions and methods
GB201322617D0 (en)	2014-02-05	Methods and compositions
GB201312393D0 (en)	2013-08-21	Compositions and Methods
GB201308949D0 (en)	2013-07-03	Compositions and methods for reducing methane production
GB201319917D0 (en)	2013-12-25	Accelerator Compositions and Methods

Movatterモバイル変換

SG11201707615YA - Methods and compositions for producing hepatocyte-like cells - Google Patents

Info

Links

Classifications

Landscapes

Applications Claiming Priority (2)

Publications (1)

Family

ID=52689587

Family Applications (3)

Family Applications Before (1)

Family Applications After (1)

Country Status (8)

Families Citing this family (6)

Family Cites Families (45)

Also Published As

Similar Documents