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SG11201506099XA - Macrocyclic pyridazinone derivatives - Google Patents

Macrocyclic pyridazinone derivatives

Info

Publication number
SG11201506099XA
SG11201506099XASG11201506099XASG11201506099XASG11201506099XASG 11201506099X ASG11201506099X ASG 11201506099XASG 11201506099X ASG11201506099X ASG 11201506099XASG 11201506099X ASG11201506099X ASG 11201506099XASG 11201506099X ASG11201506099X ASG 11201506099XA
Authority
SG
Singapore
Prior art keywords
pyridazinone derivatives
macrocyclic
macrocyclic pyridazinone
derivatives
pyridazinone
Prior art date
Application number
SG11201506099XA
Inventor
Catherine Jorand-Lebrun
Santosh Kulkarni
Serge Christmann-Franck
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbhfiledCriticalMerck Patent Gmbh
Publication of SG11201506099XApublicationCriticalpatent/SG11201506099XA/en

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SG11201506099XA2013-02-072014-02-07Macrocyclic pyridazinone derivativesSG11201506099XA (en)

Applications Claiming Priority (2)

Application NumberPriority DateFiling DateTitle
EP131543912013-02-07
PCT/EP2014/000337WO2014121942A1 (en)2013-02-072014-02-07Macrocyclic pyridazinone derivatives

Publications (1)

Publication NumberPublication Date
SG11201506099XAtrue SG11201506099XA (en)2015-09-29

Family

ID=47681773

Family Applications (1)

Application NumberTitlePriority DateFiling Date
SG11201506099XASG11201506099XA (en)2013-02-072014-02-07Macrocyclic pyridazinone derivatives

Country Status (22)

CountryLink
US (2)US9550794B2 (en)
EP (1)EP2953952B1 (en)
JP (1)JP6267729B2 (en)
KR (1)KR102216812B1 (en)
CN (1)CN105008371B (en)
AU (1)AU2014214254B2 (en)
BR (1)BR112015018751A2 (en)
CA (1)CA2900442C (en)
DK (1)DK2953952T3 (en)
ES (1)ES2639717T3 (en)
HR (1)HRP20171302T1 (en)
HU (1)HUE035919T2 (en)
IL (1)IL240291B (en)
LT (1)LT2953952T (en)
MX (1)MX367897B (en)
PL (1)PL2953952T3 (en)
PT (1)PT2953952T (en)
RS (1)RS56269B1 (en)
RU (1)RU2660435C2 (en)
SG (1)SG11201506099XA (en)
SI (1)SI2953952T1 (en)
WO (1)WO2014121942A1 (en)

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RS56331B1 (en)*2013-02-072017-12-29Merck Patent GmbhPyridazinone-amides derivatives
US9708324B2 (en)2015-02-052017-07-18Merck Patent GmbhMacrocyclic compounds as IRAK1/4 inhibitors and uses thereof
CA2970550C (en)*2015-02-062023-09-19Merck Patent GmbhPyridazinone macrocycles as irak inhibitors and uses thereof
EA039043B1 (en)2015-04-222021-11-25Райджел Фармасьютикалз, Инк.Pyrazole compounds and method for making and using the compounds
JOP20180011A1 (en)2017-02-162019-01-30Gilead Sciences Inc Perulo derivatives [1, 2-b] pyridazine
MX2020003190A (en)2017-09-222020-11-11Kymera Therapeutics IncProtein degraders and uses thereof.
US11358948B2 (en)2017-09-222022-06-14Kymera Therapeutics, Inc.CRBN ligands and uses thereof
WO2019111218A1 (en)2017-12-082019-06-13Cadila Healthcare LimitedNovel heterocyclic compounds as irak4 inhibitors
IL315310A (en)2017-12-262024-10-01Kymera Therapeutics Inc IRAK joints and used in them
EP3737666A4 (en)2018-01-122022-01-05Kymera Therapeutics, Inc.Protein degraders and uses thereof
WO2019140387A1 (en)2018-01-122019-07-18Kymera Therapeutics, Inc.Crbn ligands and uses thereof
WO2019236625A1 (en)2018-06-042019-12-12Ohio State Innovation FoundationEaat2 activators and methods of using thereof
US11292792B2 (en)2018-07-062022-04-05Kymera Therapeutics, Inc.Tricyclic CRBN ligands and uses thereof
TWI721483B (en)2018-07-132021-03-11美商基利科學股份有限公司Pyrrolo[1,2-b]pyridazine derivatives
BR112021010484A2 (en)2018-11-302021-08-24Kymera Therapeutics, Inc. Irak degraders and their uses
JP7590996B2 (en)*2019-06-242024-11-27ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Novel macrocyclic compounds and derivatives as EGFR inhibitors
JP2022545542A (en)2019-08-302022-10-27ライジェル ファーマシューティカルズ, インコーポレイテッド Pyrazole compounds, formulations thereof and methods of using the compounds and/or formulations
CA3159561A1 (en)2019-11-042021-05-14Revolution Medicines, Inc.Ras inhibitors
BR112022011651A2 (en)2019-12-172022-08-23Kymera Therapeutics Inc IRAK DEGRADATORS AND USES THEREOF
EP4076524A4 (en)2019-12-172023-11-29Kymera Therapeutics, Inc. IRAQ DEGRADERS AND USES THEREOF
TW202210483A (en)2020-06-032022-03-16美商凱麥拉醫療公司Crystalline forms of irak degraders
CN116457358A (en)2020-09-152023-07-18锐新医药公司Indole derivatives as RAS inhibitors for the treatment of cancer
WO2022117051A1 (en)*2020-12-032022-06-09北京鞍石生物科技有限责任公司Macrocyclic compound, preparation method therefor and use thereof
AU2021413371A1 (en)2020-12-302023-07-13Kymera Therapeutics, Inc.Irak degraders and uses thereof
MX2023009527A (en)2021-02-152023-08-24Kymera Therapeutics IncIrak4 degraders and uses thereof.
US12357623B2 (en)2021-03-032025-07-15Rigel Pharmaceuticals, Inc.Method for treating a disease or condition using a pyrazole compound or formulation thereof
WO2022235870A1 (en)2021-05-052022-11-10Revolution Medicines, Inc.Ras inhibitors for the treatment of cancer
PH12023500023A1 (en)2021-05-072024-03-11Kymera Therapeutics IncCdk2 degraders and uses thereof
AR127308A1 (en)2021-10-082024-01-10Revolution Medicines Inc RAS INHIBITORS
JP2024540080A (en)2021-10-292024-10-31カイメラ セラピューティクス, インコーポレイテッド IRAK4 degraders and their synthesis
TW202339738A (en)2022-01-312023-10-16美商凱麥拉醫療公司Irak degraders and uses thereof
TW202346291A (en)2022-03-232023-12-01美商雷傑製藥公司Pyrimid-2-yl-pyrazole compounds as irak inhibitors
EP4615850A1 (en)*2022-11-102025-09-17BeiGene Switzerland GmbHCompounds for the degradation of egfr kinase

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ES2367422T3 (en)*2001-10-092011-11-03Amgen Inc. IMIDAZOL DERIVATIVES AS ANTI-INFLAMMATORY AGENTS.
WO2004083188A1 (en)*2003-03-182004-09-30Kowa Co., Ltd.Water-soluble phenylpyridazine derivative and medicine containing the same
EP2061786A2 (en)*2006-09-072009-05-27Biogen Idec MA Inc.Indazole derivatives as modulators of interleukin-1 receptor-associated kinase
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RS55165B1 (en)*2010-12-202017-01-31Merck Serono SaIndazolyl triazole derivatives as irak inhibitors

Also Published As

Publication numberPublication date
US20170143713A1 (en)2017-05-25
JP2016507539A (en)2016-03-10
IL240291B (en)2019-06-30
HUE035919T2 (en)2018-05-28
AU2014214254B2 (en)2018-03-29
US20150376206A1 (en)2015-12-31
KR20150118980A (en)2015-10-23
RS56269B1 (en)2017-11-30
PT2953952T (en)2017-09-11
HRP20171302T1 (en)2017-10-20
RU2660435C2 (en)2018-07-06
PL2953952T3 (en)2017-10-31
SI2953952T1 (en)2017-10-30
KR102216812B1 (en)2021-02-18
AU2014214254A1 (en)2015-09-17
RU2015137756A (en)2017-03-13
DK2953952T3 (en)2017-08-28
HK1216645A1 (en)2016-11-25
CN105008371A (en)2015-10-28
ES2639717T3 (en)2017-10-30
US10064861B2 (en)2018-09-04
MX367897B (en)2019-09-11
US9550794B2 (en)2017-01-24
CA2900442A1 (en)2014-08-14
CA2900442C (en)2021-09-21
IL240291A0 (en)2015-09-24
MX2015010128A (en)2017-07-26
JP6267729B2 (en)2018-01-24
BR112015018751A2 (en)2017-07-18
WO2014121942A1 (en)2014-08-14
LT2953952T (en)2017-08-25
CN105008371B (en)2018-09-18
EP2953952B1 (en)2017-06-07
EP2953952A1 (en)2015-12-16

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